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https://www.readbyqxmd.com/read/29352447/long-term-endocrine-effects-and-trends-in-body-mass-index-changes-in-patients-with-childhood-onset-brain-tumors
#1
Go Hun Seo, Jin-Ho Choi, Yoon-Myung Kim, Kyung-Nam Koh, Ho Joon Im, Young Shin Ra, Han-Wook Yoo
As survival rates have improved owing to advances in management strategies for pediatric brain tumors, long-term complications such as endocrine dysfunction, have emerged as a major issue. This study investigated the long-term endocrine effects of childhood-onset brain tumors in a large number of patients. This study included 151 patients with brain tumors diagnosed between January 1995 and December 2016. The following data were retrospectively reviewed: tumor location, tumor histology, endocrine abnormalities, hypothalamic involvement on brain imaging, treatment modalities, and trends in body mass index...
January 19, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29338679/therapeutic-role-of-methotrexate-in-pediatric-crohn-s-disease
#2
REVIEW
Zlatko Djurić, Ljiljana Šaranac, Ivana Budić, Voja Pavlović, Jelena Djordjević
The main role of therapy in Crohn's disease is to achieve long-term clinical remission, and to allow for normal growth and development of children. The immunomodulatory drugs used for the maintenance of remission in Crohn's disease include thiopurines (azathioprine and 6-mercaptopurine) and methotrexate. Development of hepatosplenic T-cell lymphoma in some patients with inflammatory bowel disease, treated with thiopurines independently or in combination with anti-tumor necrosis factor agents, resulted in a growing interest in the therapeutic application of methotrexate in children suffering from Crohn's disease...
January 16, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29329145/orthopaedic-management-of-leg-length-discrepancy-in-proteus-syndrome-a-case-series
#3
Molly M Crenshaw, Cara G Goerlich, Lauren E Ivey, Julie C Sapp, Kim M Keppler-Noreuil, Allison C Scott, Leslie G Biesecker, Laura L Tosi
INTRODUCTION: Proteus syndrome (PS) is a rare mosaic disorder comprising asymmetric bony and soft tissue overgrowth leading to significant morbidity. Placement of growth inhibition hardware with subsequent epiphyseal arrest improves leg-length and angular deformities in pediatric patients without PS. The purpose of this study was to review the surgical approach and present outcomes, complications, and recommendations in 8 patients with PS and leg-length discrepancy (LLD). METHODS: We conducted a retrospective chart review of 8 patients with PS whose primary reason for surgery was LLD...
January 11, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29326814/paediatric-dentistry-novel-evolvement
#4
REVIEW
Saleha Shah
Pediatric dentistry provides primary and comprehensive preventive and therapeutic oral health care for infants and children through adolescence, together with special health care needs. This specialty encompasses a variety of skills, disciplines, procedures and techniques that share a common origin with other dental specialties however these have been modified and reformed to the distinctive requirements of infants, children, adolescents and special health care needs. Disciplines comprise of behavior guidance, care of the medically and developmentally compromised and disabled patient, supervision of orofacial growth and development, caries prevention, sedation, pharmacological management, and hospital dentistry including other traditional fields of dentistry...
January 2018: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/29326088/age-effects-of-distinct-immune-checkpoint-blockade-treatments-in-a-mouse-melanoma-model
#5
Álvaro Padrón, Vincent Hurez, Harshita B Gupta, Curtis A Clark, Sri Lakshmi Pandeswara, Bin Yuan, Robert S Svatek, Mary Jo Turk, Justin M Drerup, Rong Li, Tyler J Curiel
Cancer immunotherapy has shown remarkable recent progress. Immune checkpoint blocking antibodies have become the most successful anti-cancer agent class ever developed, with six distinct agents approved since 2011 for a wide variety of cancers. Although age is the biggest risk factor for cancer (aside from selected early-onset pediatric cancers), these agents were tested pre-clinically in young hosts, and there is remarkably little published on the effects of host age on treatment outcomes in pre-clinical studies or human clinical trials...
January 8, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29323694/the-short-child
#6
Armin Valdes, Jorge Cervantes, Yezika Delgado, Marisol Valdes, Hector Granados
Growth is one of the most important characteristics of human development. This process occurs from the moment of conception through the final stages of puberty. There are multiple factors that contribute to growth in humans. Although it may seem complex, a pediatrician should note that growth can be fairly predictable. The advantage to predictable changes in growth is that clinicians should be able to promptly detect any deviation and evaluate it in a timely manner. One of the most helpful tools to assess changes in growth is the use of a growth chart...
January 1, 2018: Pediatric Annals
https://www.readbyqxmd.com/read/29323428/enteral-nutrition-in-the-management-of-crohn-s-disease-reviewing-mechanisms-of-actions-and-highlighting-potential-venues-for-enhancing-the-efficacy
#7
REVIEW
Moftah H Alhagamhmad
Crohn's disease (CD) is a chronic condition that affects the gut and has adverse effects on growth and development. There is a global increase in the incidence and prevalence rates, and several factors are believed to contribute to this rise, including dietary habits. In contrast, the use of enteral nutrition (EN) as an exclusive source of nutrition is increasingly becoming the preferred induction treatment of pediatric CD patients in part to address the nutrition complications. However, EN therapy is considered less effective in adults with CD...
January 11, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29321443/a-new-arena-in-cardiac-surgery-pediatric-coronary-artery-bypass-surgery
#8
Soichiro Kitamura
Prior to the 1970s, pediatric coronary artery bypass surgery (PCABS) was seldomly performed due to the lack of compelling surgical indications. The advent of coronary sequelae secondary to Kawasaki disease (KD) and the occurrence of coronary artery complications due to newly developed procedures, such as the arterial switch operation and early repair for intrinsic congenital coronary malformations, necessitated the development of PCABS. Because children grow rapidly and their life expectancy is very long, with increasing exercise capability requirements, the strategy for PCABS should differ from that for bypass surgery in adults...
2018: Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
https://www.readbyqxmd.com/read/29320484/brain-growth-in-the-nicu-critical-periods-of-tissue-specific-expansion
#9
Lillian G Matthews, Brian H Walsh, Clare Knutsen, Jeffrey J Neil, Christopher D Smyser, Cynthia E Rogers, Terrie E Inder
OBJECTIVE: To examine using serial MRI, total and tissue-specific brain growth in VPT infants during the period that coincides with the early and late stages of the third trimester. METHODS: Structural MRI scans were collected from two prospective cohorts of VPT infants (≤30 weeks' gestation). 51 MRI scans from 18 VPT subjects were available for volumetric analysis. Brain tissue was classified into cerebrospinal fluid, cortical grey matter, myelinated and unmyelinated white matter, deep nuclear grey matter, and cerebellum...
January 10, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29300907/a-6-year-follow-up-of-fracture-incidence-and-volumetric-bone-mineral-density-development-in-girls-with-turner-syndrome
#10
Ondrej Soucek, Eckhard Schönau, Jan Lebl, Johannes Willnecker, Zdenek Hlavka, Zdenek Sumnik
Context: Patients with Turner Syndrome (TS) are at risk of osteoporotic fractures. Objective: The aims of this study were to assess the incidence of clinically significant fractures in girls with TS and prospectively describe the development of volumetric bone mineral density (BMD). Design: Peripheral quantitative computerized tomography (pQCT) of the radius every other year over the 6 years of observation. Setting: Government funded university referral center...
December 28, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29300097/parameter-uncertainty-in-structural-equation-models-confidence-sets-and-fungible-estimates
#11
Jolynn Pek, Hao Wu
Current concerns regarding the dependability of psychological findings call for methodological developments to provide additional evidence in support of scientific conclusions. This article highlights the value and importance of two distinct kinds of parameter uncertainty, which are quantified by confidence sets (CSs) and fungible parameter estimates (FPEs; Lee, MacCallum, & Browne, 2017); both provide essential information regarding the defensibility of scientific findings. Using the structural equation model, we introduce a general perturbation framework based on the likelihood function that unifies CSs and FPEs and sheds new light on the conceptual distinctions between them...
January 4, 2018: Psychological Methods
https://www.readbyqxmd.com/read/29296717/homeobox-protein-tlx3-activates-mir-125b-expression-to-promote-t-cell-acute-lymphoblastic-leukemia
#12
Laurent Renou, Pierre-Yves Boelle, Caroline Deswarte, Salvatore Spicuglia, Aissa Benyoucef, Julien Calvo, Benjamin Uzan, Mohamed Belhocine, Agata Cieslak, Judith Landman-Parker, Andre Baruchel, Vahid Asnafi, Françoise Pflumio, Paola Ballerini, Irina Naguibneva
The oncogenic mechanisms driven by aberrantly expressed transcription factors in T-cell acute leukemia (T-ALL) are still elusive. MicroRNAs (miRNAs) play an important role in normal development and pathologies. Here, we examined the expression of 738 miRNA species in 41 newly diagnosed pediatric T-ALLs and in human thymus-derived cells. We found that expression of 2 clustered miRNAs, miR-125b/99a, peaks in primitive T cells and is upregulated in the T leukemia homeobox 3 (TLX3)-positive subtype of T-ALL. Using loss- and gain-of-function approaches, we established functional relationships between TLX3 and miR-125b...
May 9, 2017: Blood Advances
https://www.readbyqxmd.com/read/29290407/expanding-access-to-clinical-services-for-toddlers-with-autism-spectrum-disorders
#13
Therese L Mathews, Ashley M Lugo, Melissa L King, Laura L Needelman, Paige E McArdle, Natalie Romer, Megan Terry, Kathryn Menousek, Joseph H Evans, William J Higgins
Autism spectrum disorder (ASD) is a neurodevelopmental disorder typically diagnosed in the toddler and preschool years. Intensive early intervention (EI) using applied behavior analytic procedures is the evidenced-based intervention most effective in improving developmental outcomes. Unfortunately, there are numerous barriers to accessing EI services for toddlers with ASD. This article addresses (a) the process of developing an EI program using primarily applied behavior analytic services with multidisciplinary health care providers, (b) a description of the service delivery provided, (c) educational and training programs to increase qualified staff, and (d) advocacy efforts to improve community capacity...
December 28, 2017: Journal of Pediatric Health Care
https://www.readbyqxmd.com/read/29277901/community-partnership-for-healthy-sleep-research-protocol
#14
Nancy S Redeker, Monica R Ordway, Nancy Banasiak, Barbara Caldwell, Craig Canapari, Angela Crowley, Ada Fenick, Sangchoon Jeon, Meghan O'Connell, Leslie Sude, Lois S Sadler
Beginning early in life, sleep health, including adequate quality, quantity, and consistent sleep routines, is critical to growth and development, behavior, and mental and physical health. Children who live in economically stressed urban environments are at particular risk for sleep deficiency and its negative consequences. Although efficacious sleep health interventions are available, few address the context of economically stressed urban environments. The purpose of this paper is to describe a two-phase protocol for an ongoing NIH/NINR-funded community-engaged study designed to understand the perspectives of parents, community child care and pediatric health care providers about sleep habits, factors that contribute to sleep and sleep habits, sleep difficulty, and potentially useful sleep promotion strategies among children living in economically stressed urban environments...
December 26, 2017: Research in Nursing & Health
https://www.readbyqxmd.com/read/29277262/pancreatectomies-for-pancreatic-neoplasms-in-pediatric-and-adolescent-age-a-single-institution-experience
#15
Chiara Scandavini, Roberto Valente, Elena Rangelova, Ralf Segersvärd, Urban Arnelo, Johan Permert, Pär-Johan Svensson, Jakob Stenman, Marco Del Chiaro
BACKGROUND: There are very few data in the current literature regarding the short- and long-term outcome of surgery for pediatric pancreatic tumors (PPT). No data are available on the impact of pancreatic surgery on the children's growth. METHODS: This is a retrospective cohort study on a consecutive series of pediatric/adolescent patients who underwent pediatric surgery at Karolinska University Hospital from January 2005 to July 2017. RESULTS: Overall 14 pancreatic operations were performed in 13 patients...
December 19, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29262471/-correlation-between-serum-25-hydroxyvitamin-d-level-and-core-symptoms-of-autism-spectrum-disorder-in-children
#16
H Y Dong, B Wang, H H Li, L Shan, F Y Jia
Objective: To explore the relationship between serum 25-hydroxyvitamin D levels and core symptoms of autism spectrum disorder (ASD) in children. Method: In this cross-sectional study, ASD children 4 to 6 years of age who were diagnosed in Department of Developmental and Behavioral Pediatrics, First Hospital of Jilin university from January to May 2017 were assigned to ASD group, and children for routine growth and development assessment in Jilin province were assigned to control group. The two groups were well matched for age and sex, and none of them had received vitamin D supplementation...
December 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29245068/overexpression-of-microrna-375-impedes-platelet-derived-growth-factor-induced-proliferation-and-migration-of-human-fetal-airway-smooth-muscle-cells-by-targeting-janus-kinase-2
#17
Yamei Ji, Xin Yang, Huixia Su
The abnormal proliferation and migration of airway smooth muscle (ASM) cells play a critical role in airway remodeling during the development of asthma. MicroRNAs (miRNAs) have emerged as critical regulators of ASM cell proliferation and migration in airway remodeling. In this study, we aimed to investigate the potential role of miR-375 in the regulation of platelet-derived growth factor (PDGF)-induced fetal ASM cell proliferation and migration. Our results showed that miR-375 expression was significantly decreased in fetal ASM cells that were treated with PDGF...
December 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29244803/changes-in-brain-morphology-and-microstructure-in-relation-to-early-brain-activity-in-extremely-preterm-infants
#18
Maria Luisa Tataranno, Nathalie H P Claessens, Pim Moeskops, Mona C Toet, Karina J Kersbergen, Giuseppe Buonocore, Ivana Išgum, Alexander Leemans, Serena Counsell, Floris Groenendaal, Linda S de Vries, Manon J N L Benders
OBJECTIVE: To investigate the relation of early brain activity with structural (growth of the cortex and cerebellum) and white matter microstructural brain development. METHODS: 33 preterm neonates (gestational age 26±1 weeks) without major brain abnormalities were continuously monitored with electroencephalography (EEG) during the first 48 h of life. Rate of spontaneous activity transients per minute (SAT rate) and interSAT interval (ISI) in seconds per minute were calculated...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244799/prenatal-and-early-postnatal-measures-of-brain-development-and-childhood-sleep-patterns
#19
Desana Kocevska, Maria E Verhoeff, Selma Meinderts, Vincent W Jaddoe, Frank C Verhulst, Sabine J Roza, Maartje P C M Luijk, Henning Tiemeier
BACKGROUND: Brain development underlies maturation of sleep patterns throughout childhood. Intrauterine head growth -marker of early neurodevelopment- has not been associated with childhood sleep characteristics. We explored associations between ultrasonographic measures of prenatal and early postnatal neurodevelopment and childhood sleep. METHODS: Six-thousand-five-hundred-twenty-eight children from a population-based birth cohort (Generation R) were included. Head circumference (HC) and lateral ventricles size were assessed with mid- and late-pregnancy fetal ultrasounds, and with cranial ultrasound 3-20 weeks postnatally...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29230635/quality-of-life-and-growth-after-childhood-craniopharyngioma-results-of-the-multinational-trial%C3%A2-kraniopharyngeom-2007
#20
Kerstin Heinks, Svenja Boekhoff, Anika Hoffmann, Monika Warmuth-Metz, Maria Eveslage, Junxiang Peng, Gabriele Calaminus, Hermann L Müller
CONTEXT: Quality of life (QoL) after childhood-onset craniopharyngioma (CP) is frequently impaired due to tumor and/or treatment-related factors such as endocrine deficits and hypothalamic involvement/lesions. PATIENTS AND METHODS: In a multinational trial, we prospectively analyzed parental and self-assessment of CP patient QoL at 3 months, 1 and 3 years after CP diagnosis related to growth hormone (GH) substitution. 47 of 194 CP recruited between 2007 and 2015 in KRANIOPHARYNGEOM 2007 were analyzed for QoL 1 and 3 years after CP diagnosis...
December 11, 2017: Endocrine
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