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JOURNAL ARTICLE
Miao Chen, Haoyang Wang, Yibin Zhang, Hanyu Jiang, Tan Li, Lixin Liu, Yuetao Zhao
Identification of protein profiling on plasma exosomes by SERS can be a promising strategy for early cancer diagnosis. However, it is still challenging to detect multiple exosomal proteins simultaneously by SERS since the Raman signals of exosomes detected by conventional colloidal nanocrystals or two-dimensional SERS substrates are incomplete and complex. Herein, we develop a novel three-dimensional (3D) surround-enhancing SERS platform, named 3D se-SERS, for the multiplex detection of exosomal proteins. In this 3D se-SERS, proteins and exosomes are covered with "hotspots" generated by the gold nanoparticles, which surround the analytes densely and three-dimensionally, providing sensitive and comprehensive SERS signals...
April 16, 2024: Analytical Chemistry
#2
JOURNAL ARTICLE
Youyang Shi, Yuanyuan Wu, Feifei Li, Kexin Jiang, Xiaofang Fang, Yu Wang, Xiaoyun Song, Rui Wang, Lixin Chen, Jinzhou Zheng, Chunyu Wu, Yuenong Qin, Xiaofei Liu, Sheng Liu
UNLABELLED: Recently, immunotherapy has emerged as a promising and effective method for treating triple-negative breast cancer (TNBC). However, challenges still persist. Immunogenic cell death (ICD) is considered a prospective treatment and potential combinational treatment strategy as it induces an anti-tumor immune response by presenting the antigenic epitopes of dead cells. Nevertheless, the ICD process in TNBC and its impact on disease progression and the response to immunotherapy are not well understood...
February 2024: Phenomics
#3
JOURNAL ARTICLE
Lixin Guo, Fengsheng Tian, Li Liu, Mingwei Chen, Chengxia Jiang, Shuangqing Li, Cong Liu, Yawei Zhang, Jie Qin, Dongni Yu, Yicen Zong, Wei Dai
AIM: To evaluate the efficacy and safety of retagliptin in Chinese patients with type 2 diabetes (T2D) inadequately controlled with metformin. MATERIALS AND METHODS: This multicentre, phase 3 trial consisted of a 16-week, randomized, double-blind, placebo-controlled period, where patients with HbA1c levels between 7.5% and 11.0% were randomized to receive either once-daily (QD) retagliptin 100 mg (n = 87) or placebo (n = 87), both as an add-on to metformin...
April 11, 2024: Diabetes, Obesity & Metabolism
#4
JOURNAL ARTICLE
Rui La, Liyu Zhou, Yunfei Yin, Lingchen Lu, Lisong Li, Dinghua Jiang, Lixin Huang, Qian Wu
OBJECTIVE: Although oxidative stress is a recognized factor of inflammation, the correlation between oxidative balance score (OBS), a biomarker indicating the balance of oxidation and antioxidant, and rheumatoid arthritis (RA), an immune system disease that tends to occur in women, remains unexplored. Hence, the aim of this study was to investigate the potential association between OBS and RA in women. METHODS: Observational surveys were performed by employing information extracted from the National Health and Nutrition Examination Survey (NHANES) for the period 2007-2018...
April 6, 2024: BMC Women's Health
#5
JOURNAL ARTICLE
Jiacheng Qi, Xu Huang, Xuezhang Xiao, Xinyi Zhang, Panpan Zhou, Shuoqing Zhang, Ruhong Li, Huaqin Kou, Fei Jiang, Yong Yao, Jiangfeng Song, Xingwen Feng, Yan Shi, Wenhua Luo, Lixin Chen
Deuterium/Tritium (D/T) handling in defined proportions are pivotal to maintain steady-state operation for fusion reactors. However, the hydrogen isotope effect in metal-hydrogen systems always disturbs precise D/T ratio control. Here, we reveal the dominance of kinetic isotope effect during desorption. To reconcile the thermodynamic stability and isotope effect, we demonstrate a quantitative indicator of Tgap and further a local coordination design strategy that comprises thermodynamic destabilization with vibration enhancement of interstitial isotopes for isotope engineering...
April 3, 2024: Nature Communications
#6
JOURNAL ARTICLE
Huiyu Liu, Yuan Jiang, Ruimin Shi, Yingying Hao, Mengnan Li, June Bai, Hongdan Wang, Xiaoyu Guan, Xinyue Song, Cui Ma, Lixin Zhang, Xijuan Zhao, Xiaodong Zheng, Daling Zhu
BACKGROUND: Pulmonary hypertension (PH) is a complex vascular disorder, characterized by pulmonary vessel remodeling and perivascular inflammation. Pulmonary arterial smooth muscle cells (PASMCs) pyroptosis is a novel pathological mechanism implicated of pulmonary vessel remodeling. However, the involvement of circRNAs in the process of pyroptosis and the underlying regulatory mechanisms remain inadequately understood. METHODS: Western blotting, PI staining and LDH release were used to explore the role of circLrch3 in PASMCs pyroptosis...
April 1, 2024: International Journal of Biological Macromolecules
#7
JOURNAL ARTICLE
Chuangchao Sun, Ruhong Li, Suting Weng, Chunnan Zhu, Long Chen, Sen Jiang, Long Li, Xuezhang Xiao, Chengwu Liu, Lixin Chen, Tao Deng, Xuefeng Wang, Xiulin Fan
Lithium batteries employing Li or silicon (Si) anodes hold promise for the next-generation energy storage systems. However, their cycling behavior encounters rapid capacity degradation due to the vulnerability of solid electrolyte interphases (SEIs). Though anion-derived SEIs mitigate this degradation, the unavoidable reduction of solvents introduces heterogeneity to SEIs, leading to fractures during cycling. Here, we elucidate how the reductive stability of solvents, dominated by the electrophilicity (EPT) and coordination ability (CDA), delineates the SEI formed on Li or Si anodes...
March 18, 2024: Angewandte Chemie
#8
JOURNAL ARTICLE
Xintong Zhang, Haozhe Guo, Wenbin He, Xiaocong Wang, Qi Huang, Yu Zheng, Ruochen Yin, Zhiyuan Huang, Xin Jiang, Lixin Xu, Yuxin Leng, Meng Pang
This publisher's note contains a correction to Opt. Lett.49, 674 (2024)10.1364/OL.509981.
March 15, 2024: Optics Letters
#9
JOURNAL ARTICLE
Dan Zhu, Yingying Liu, Lixin Gong, Man Si, Qiuya Wang, Jiang Feng, Tinglei Jiang
Insectivorous bats are generalist predators and can flexibly respond to fluctuations in the distribution and abundance of insect prey. To better understand the effects of bats on arthropod pests, the types of pests eaten by bats and the response of bats to insect prey need to be determined. In this study, we performed DNA metabarcoding to examine prey composition and pest diversity in the diets of four insectivorous species of bats ( Hipposideros armiger , Taphozous melanopogon , Aselliscus stoliczkanus , and Miniopterus fuliginosus )...
March 6, 2024: Animals: An Open Access Journal From MDPI
#10
JOURNAL ARTICLE
Junping Han, Bin Zhuang, Lixin Zou, Daoyu Wang, Li Jiang, Yi-Liang Wei, Lijian Zhao, Lei Zhao, Caixia Li
Analysis of short tandem repeats (STRs) is a global standard method for human identification. Insertion/Deletion polymorphisms (DIPs) can be used for biogeographical ancestry inference. Current DNA typing involves a trained forensic worker operating several specialized instruments in a controlled laboratory environment, which takes 6-8 h. We developed the Quick TargSeq 1.0 integrated system (hereinafter abbreviated to Quick TargSeq) for automated generation of STR and DIP profiles from buccal swab samples and blood stains...
March 9, 2024: Electrophoresis
#11
JOURNAL ARTICLE
Wen Jiang, Thayalan Rajeshkumar, Mengyue Guo, Yuejian Lin, Laurent Maron, Lixin Zhang
Guanidinate homometallic rare-earth ethyl complexes [LLn( μ 2 - η 1 : η 2 -Et)(Et)]2 (Ln = Y(1-Y), Lu(1-Lu)) and heterobimetallic rare-earth ethyl complexes LLn(Et)( μ 2 - η 1 : η 2 -Et)( μ 2 - η 1 -Et)(AlEt2 ) (Ln = Y(2-Y), Lu(2-Lu)) have been synthesized by the treatment of LLn(CH2 C6 H4 NMe2 - o )2 (L = (PhCH2 )2 NC(NC6 H3 i Pr2 -2,6)2 ) with different equivalents of AlEt3 in toluene at ambient temperature. Interestingly, the unprecedented rare-earth ethyne complex [LY( μ 2 - η 1 -Et)2 (AlEt)]2 ( μ 4 - η 1 : η 1 : η 2 : η 2 -C2 H2 ) (3-Y) containing a [C2 H2 ]4- unit was afforded from 2-Y...
March 6, 2024: Chemical Science
#12
JOURNAL ARTICLE
Lixin Wang, Gang Chen, Jingui Jiang, Guoyan Liu, Ying-Lan Tuo, Xiaohong Li, Weishan Zhang
AIM: This study examines the clinical and pathological characteristics, immune profile, histological occurrence, diagnosis, and differential diagnosis of vulvar hidradenoma papilliferum. METHODS: An analysis was conducted on clinical data, histological patterns, and immunohistochemical findings from 45 cases of vulvar hidradenoma papilliferum, and relevant published articles were reviewed. Simultaneously, high-risk HPV typing was performed on these 45 cases. RESULTS: The 45 cases of vulvar hidradenoma papilliferum displayed tumor sizes ranging from 0...
2024: International Journal of General Medicine
#13
Yuxin Yan, Liyu Zhou, Rui La, Ming Jiang, Dinghua Jiang, Lixin Huang, Wu Xu, Qian Wu
No abstract text is available yet for this article.
February 27, 2024: Lipids in Health and Disease
#14
JOURNAL ARTICLE
Yiwen Zheng, Mengyao Liu, Qian Yu, Rui Wang, Yijing Yao, Lixin Jiang
Previous studies have shown that ultrasound may stimulate the release of extracellular vesicles, improving the efficiency of tumor detection. However, it is unclear whether ultrasonic stimulation affects the distribution of extracellular vesicles, and the duration of such stimulation release has not been extensively studied. In this study, we stimulated cells with low-intensity pulsed ultrasound and used liposomes containing black hole quenchers to simulate natural extracellular vesicles, confirming that ultrasound has a destructive effect on vesicles and thus affects particle size distribution...
February 27, 2024: Nanoscale
#15
REVIEW
Ting Tong, Aiqing Xu, Shuhua Tan, Hengzhi Jiang, Lixin Liu, Senwen Deng, Haihua Wang
The dried, mature fruit of the palm tree species Areca catechu L. is known as the areca nut (AN) or betel nut. It is widely cultivated in the tropical regions. In many nations, AN is utilized for traditional herbal treatments or social activities. AN has historically been used to address various health issues, such as diarrhea, arthritis, dyspepsia, malaria, and so on. In this review, we have conducted a comprehensive summary of the biological effects and biomedical applications of AN and its extracts. Initially, we provided an overview of the constituents in AN extract...
February 8, 2024: Pharmaceuticals
#16
JOURNAL ARTICLE
Zhiyuan Wu, Yue Jiang, Zheng Guo, Pingan Li, Yulu Zheng, Yutao Wang, Haiping Zhang, Lois Balmer, Xingang Li, Lixin Tao, Qi Zhang, Bo Gao, Xiuhua Guo
Observational epidemiological studies have reported a relationship between remnant cholesterol and stroke. However, the results are inconclusive, and causality remains unclear due to confounding or reverse causality. Our objective in this study was to investigate the causal relevance of remnant cholesterol and the risk of stroke and its subtypes using the Mendelian randomization (MR) approach. Genome-wide association studies (GWASs) including 115,082 European individuals (UK Biobank) were used to identify instruments for remnant cholesterol, including intermediate-density lipoprotein (IDL) cholesterol and very-low-density lipoprotein (VLDL) cholesterol...
February 2024: PNAS Nexus
#17
REVIEW
Jianhao Jiang, Lulu He, Shiwei Zheng, Junping Liu, Lixin Gong
Transport of microplastics (MPs) in coastal zones is influenced not only by their own characteristics, but also by the hydrodynamic conditions and coastal environment. In this article, we first summarized the source, distribution and abundance of MPs in coastal zones around the world through the induction of in-situ observation literature, and then comprehensively reviewed the different transports of MPs in coastal zones, including sedimentation, vertical mixing, resuspension, drift and biofouling. Afterwards, we conducted a comparative analysis of relevant experimental literature, and found that the current experimental research on microplastic transport mainly focused on the settling velocity under static water and the transport distribution under dynamic water...
February 7, 2024: Marine Environmental Research
#18
JOURNAL ARTICLE
Lei Shen, Zhourui Zhang, Pengfei Wu, Jingyi Yang, Yuankun Cai, Keyu Chen, Songshan Chai, Jingwei Zhao, Hongyu Chen, Xuan Dai, Bangkun Yang, Wei Wei, Lixin Dong, Jincao Chen, Pucha Jiang, Changjun Cao, Chao Ma, Chengshi Xu, Yichun Zou, Jibo Zhang, Wenping Xiong, Zhengwei Li, Shuangxiang Xu, Bing Shu, Mengyang Wang, Zejin Li, Qiongqiong Wan, Nanxiang Xiong, Suming Chen
Characterizing the tumor microenvironment at the molecular level is essential for understanding the mechanisms of tumorigenesis and evolution. However, the specificity of the blood proteome in localized region of the tumor and its linkages with other systems is difficult to investigate. Here, we propose a spatially multidimensional comparative proteomics strategy using glioma as an example. The blood proteome signature of tumor microenvironment was specifically identified by in situ collection of arterial and venous blood from the glioma region of the brain for comparison with peripheral blood...
February 16, 2024: Science Advances
#19
Ann Y Park, Michael Leney-Greene, Matthew Lynberg, Justin Q Gabrielski, Xijin Xu, Benjamin Schwarz, Lixin Zheng, Arasu Balasubramaniyam, Hyoungjun Ham, Brittany Chao, Yu Zhang, Helen F Matthews, Jing Cui, Yikun Yao, Satoshi Kubo, Jean Michel Chanchu, Aaron R Morawski, Sarah A Cook, Ping Jiang, Juan C Ravell, Yan H Cheng, Alex George, Aiman Faruqi, Alison M Pagalilauan, Jenna R E Bergerson, Sundar Ganesan, Samuel D Chauvin, Jahnavi Aluri, Joy Edwards-Hicks, Eric Bohrnsen, Caroline Tippett, Habib Omar, Leilei Xu, Geoffrey W Butcher, John Pascall, Elif Karakoc-Aydiner, Ayca Kiykim, Holden Maecker, İlhan Tezcan, Saliha Esenboga, Raul Jimenez Heredia, Deniz Akata, Saban Tekin, Altan Kara, Zarife Kuloglu, Emel Unal, Tanıl Kendirli, Figen Dogu, Esra Karabiber, T Prescott Atkinson, Claude Cochet, Odile Filhol, Catherine M Bosio, Mark M Davis, Richard P Lifton, Erika L Pearce, Oliver Daumke, Caner Aytekin, Gülseren Evirgen Şahin, Aysel Ünlüsoy Aksu, Gulbu Uzel, V Koneti Rao, Sinan Sari, Buket Dalgıç, Kaan Boztug, Deniz Cagdas, Sule Haskologlu, Aydan Ikinciogullari, David Schwefel, Silvia Vilarinho, Safa Baris, Ahmet Ozen, Helen C Su, Michael J Lenardo
No abstract text is available yet for this article.
April 2024: Nature Immunology
#20
JOURNAL ARTICLE
Yuan Wu, Qian Zhang, Yutong Deng, Xiang Ding, Han Xie, Shuang Wang, Chang Liu, Ming Li, Lixin Cai, Yuwu Jiang
AIM: To investigate the developmental effects of epilepsy surgery in young children. METHOD: This study retrospectively reviewed 315 consecutive children under 3 years of age, and ultimately included 89 children (48 males, 41 females) with pre- and postsurgery developmental evaluations. RESULTS: The mean general quotient before surgery was 46.7 (SD 24.7). Before surgery, the general quotient decreased in 77.6% of patients, while after surgery it increased in 55...
February 11, 2024: Developmental Medicine and Child Neurology
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