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Lixin Jiang

Lei Liang, Xue Yang, Yang Yu, Xiaoyong Li, Yechen Wu, Rongyu Shi, Jinghua Jiang, Lu Gao, Fei Ye, Qiudong Zhao, Rong Li, Lixin Wei, Zhipeng Han
Babao Dan (BBD), a traditional Chinese medicine, has been widely used as a complementary and alternative medicine to treat chronic liver diseases. In this study, we aimed to observe the protective effect of BBD on rat hepatic fibrosis induced by diethylnitrosamine (DEN) and explore it possible mechanism. BBD was administrated while DEN was given. After eight weeks, values of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) indicated that BBD significantly protected liver from damaging by DEN and had no obvious side effect on normal rat livers...
October 20, 2016: Oncotarget
Laura Petitta, Lixin Jiang, Charmine E J Härtel
The present study adds novel knowledge to the literature on emotional contagion (EC), discrete emotions, job burnout, and the management of healthcare professionals by simultaneously considering EC as both a job demand and a job resource with multiple social pathways. Integrating EC into the job demands-resource model, we develop and test a conceptual model wherein multiple stakeholder sources of emotional exchanges (i.e., leaders, colleagues, patients) play a differential role in predicting caregivers' absorption of positive (i...
October 10, 2016: Stress and Health: Journal of the International Society for the Investigation of Stress
Lei Shi, Fengrui Jiang, Bao Li, Lixin Wu
We show that chirality transfer from chiral polyoxometalates to achiral polyoxometalates can occur in aqueous solution with unexpected selectivity of surrounding counterions. In comparison with sodium ions, protonated dimethylammonium counterions play a critical role in shortening the inter-cluster distance, thus promoting the efficiency of chirality transfer.
October 18, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Wanhong Zuo, Liwei Wang, Lixin Chen, Krešimir Krnjević, Rao Fu, Xia Feng, Wen He, Seungwoo Kang, Avi Shah, Alex Bekker, Jiang-Hong Ye
Ethanol's aversive property may limit it's use, but the underlying mechanisms are no well-understood. Emerging evidence suggests a critical role for the lateral habenula (LHb) in the aversive response to various drugs, including ethanol. We previously showed that ethanol enhances glutamatergic transmission and stimulates LHb neurons. GABAergic transmission, a major target of ethanol in many brain regions, also tightly regulates LHb activity. This study assessed the action of ethanol on LHb GABAergic transmission in rat brain slices...
September 25, 2016: Neuropharmacology
Chengyan Wang, Kai Zhao, Rui Zhang, Li Jiang, Rui Wang, Xiaodong Zhang, He Wang, Lixin Jin, Jue Zhang, Xiaoying Wang, Jing Fang
The purpose of this study is to demonstrate the feasibility of dynamic renal R2 /R2 '/R2 * measurements based on a method, denoted psMASE-ME, in which a periodic 180° pulse-shifting multi-echo asymmetric spin echo (psMASE) sequence, combined with a moving estimation (ME) strategy, is adopted. Following approval by the institutional animal care and use committee, a block design of respiratory challenge with interleaved air and carbogen (97% O2 , 3% CO2 ) breathing was employed in nine rabbits. Parametrical R2 /R2 '/R2 * maps were computed and average R2 /R2 '/R2 * values were measured in regions of interest in the renal medulla and cortex...
September 27, 2016: NMR in Biomedicine
Wei Jiang, Qi Wang, Xiaolei Qu, Lixin Wang, Xiaoran Wei, Dongqiang Zhu, Kun Yang
The direct contact between multi-walled carbon nanotubes (MWCNTs) and cell membranes causes membrane disruption, potentially leading to cytotoxicity. However, the role of electrostatic forces and MWCNT properties is still open to debate. In this study, the influences of charge and MWCNT surface defects on membrane disruption were investigated by microscopy and a quartz crystal microbalance with dissipation monitoring (QCM-D). Positively/negatively charged giant unilamellar vesicles (GUVs) and supported lipid bilayers (SLBs) were made as model cell membranes...
September 21, 2016: Science of the Total Environment
Matthew J Johnson, Lixin Jiang
This study examined whether meaningful work may improve one's quality of life outside of the workplace (i.e., work-to-life enrichment). More importantly, we proposed and tested competing hypotheses regarding the role of work engagement in the relationship between meaningful work and work-to-life enrichment. Specifically, we investigated whether work engagement served as a mediator of this relationship, as suggested by the job demands-resources model, or instead a moderator, as suggested by conservation of resources theory...
September 20, 2016: Stress and Health: Journal of the International Society for the Investigation of Stress
Li Ma, Jiang Zhu, Qun Gao, Mario J Rebecchi, Qiang Wang, Lixin Liu
We previously reported that pretreatment with the potent antioxidant TEMPOL improves mitochondrial function and restores preconditioning in the aging heart. Because mitophagy is implicated in cardiac preconditioning and declines with age, this study was designed to investigate how age influences mitophagy in response to preconditioning and whether TEMPOL pretreatment improves it. Old (22-24 months) rats were pretreated with or without 4-week TEMPOL and compared with young (4-6 months) untreated rats. Cardioprotection induced by isoflurane (ISO) in vivo and in isolated cardiomyocytes in vitro was assessed following ischemia/reperfusion and simulated hypoxia/reoxygenation, respectively...
August 26, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Chenfei Rao, Junzhe Du, Xi Li, Jing Li, Heng Zhang, Yan Zhao, Shengshou Hu, Lixin Jiang, Zhe Zheng
OBJECTIVES: The benefits of secondary preventive drugs after coronary artery bypass grafting have been thoroughly established. However, the prescription rates of these drugs are low at discharge in China. We sought to evaluate the effectiveness of continuous quality improvement with mobile-based interventions for clinicians on improving the guideline-adherence of secondary preventive drugs prescription. METHODS AND RESULTS: The quality MISSION-1 study is a cluster-randomized controlled trial...
August 2016: American Heart Journal
Daoyang Sun, Xinguo Zhang, Shaohua Li, Cai-Zhong Jiang, Yanlong Zhang, Lixin Niu
The L. regale ATP-binding cassette transporter gene, LrABCF1 belonging to GCN subfamily, functions as a positive regulator of plant defense against Cucumber mosaic virus, Tobacco rattle virus , and Botrytis cinerea in petunia. ATP-binding cassette (ABC) transporters are essential for membrane translocation in diverse biological processes, such as plant development and defense response. Here, a general control non-derepressible (GCN)-type ABC transporter gene, designated LrABCF1, was identified from Cucumber mosaic virus (CMV)-induced cDNA library of L...
December 2016: Planta
Michael M Engelgau, Emmanuel Peprah, Uchechukwu K A Sampson, Helena Mishoe, Ivor J Benjamin, Pamela S Douglas, Judith S Hochman, Paul M Ridker, Neal Brandes, William Checkley, Sameh El-Saharty, Majid Ezzati, Anselm Hennis, Lixin Jiang, Harlan M Krumholz, Gabrielle Lamourelle, Julie Makani, K M Venkat Narayan, Kwaku Ohene-Frempong, Sharon E Straus, David Stuckler, David A Chambers, Deshirée Belis, Glen C Bennett, Josephine E Boyington, Tony L Creazzo, Janet M de Jesus, Chitra Krishnamurti, Mia R Lowden, Antonello Punturieri, Susan T Shero, Neal S Young, Shimian Zou, George A Mensah
Almost three-quarters (74%) of all the noncommunicable disease burden is found within low- and middle-income countries. In September 2014, the National Heart, Lung, and Blood Institute held a Global Health Think Tank meeting to obtain expert advice and recommendations for addressing compelling scientific questions for late stage (T4) research-research that studies implementation strategies for proven effective interventions-to inform and guide the National Heart, Lung, and Blood Institute's global health research and training efforts...
July 21, 2016: Global Heart
Fengcai Du, Lixin Jiang, Fangqing Zhu, Zhao Hua Gong, Jian Chen, Liangming Zhang
Here, we report the case of a 77-year-old male patient who was revealed to have an unsuspected case of gastric adenocarcinoma with paravertebral plasmacytoma following biopsy. Plasmacytoma may be classified into two main groups: Multiple myeloma and plasmacytoma without marrow involvement. It comprises isolated plasmacytoma of the bone and extramedullary plasmacytoma. Extramedullary plasmacytoma (EMP) accounts for 3% of all plasmacytomas; however, ~80% are located in the upper respiratory tract and upper gastrointestinal tract...
August 2016: Oncology Letters
Hongjin Chu, Fengcai Du, Lixin Jiang, Zhixin Wang, Zhaohua Gong, Peiwen Lian, Peng Li, Jian Chen
OBJECTIVE: To investigate the efficacy of cytokine-induced killer cell-based immunotherapies in patients with advanced malignant solid tumors and the difference in clinical efficiency among 3 kinds of cytokine-induced killer cell-based immunotherapies. METHODS: One hundred forty-six cases with advanced solid tumor, 230 cycles of cytokine-induced killer cell-based immunotherapies, were involved in this study. T-lymphocyte subsets, carcinoembryonic antigen, and adverse reactions were recorded...
July 19, 2016: Technology in Cancer Research & Treatment
Xu Fu, Zhihua Wang, Lixin Li, Shishang Dong, Zhucui Li, Zhenzuo Jiang, Yuefei Wang, Wenqing Shui
The nucleoprotein (NP) of Ebola virus (EBOV) and Marburg virus (MARV) is an essential component of the viral ribonucleoprotein complex and significantly impacts replication and transcription of the viral RNA genome. Although NP is regarded as a promising antiviral druggable target, no chemical ligands have been reported to interact with EBOV NP or MARV NP. We identified two compounds from a traditional Chinese medicine Gancao (licorice root) that can bind both NPs by combining affinity mass spectrometry and metabolomics approaches...
2016: Scientific Reports
Zhenyu Shi, Jun Yang, Weiguo Fu, Daqiao Guo, Xin Xu, Bin Chen, Junhao Jiang, Jue Yang, Ting Zhu, Zhihui Dong, Lixin Wang, Yun Shi, Xiao Tang, Jianing Yue
BACKGROUND: The objective was to explore the outcomes and aortic remodelling after proximal thoracic endovascular aortic repair (TEVAR) in post type B aortic dissection thoracic aneurysm with a maximal diameter ≥ 5.5cm. PATIENTS AND METHODS: 34 cases of type B aortic dissection thoracic aneurysm undergoing proximal TEVAR (coverage of the primary entry and the aneurysm extent) from 2008 to 2013 were retrospectively reviewed with follow-up for at least 2 years. The primary endpoints were 30-day mortality and survival at 2 years...
2016: VASA. Zeitschrift Für Gefässkrankheiten
Liuyun Jiang, Lixin Jiang, Chengdong Xiong, Shengpei Su
To obtain ideal nano-hydroxyapatite(n-HA) filler for poly(lactide-co-glycolide) (PLGA), a new surface-grafting with the assist of citric acid for nano-hydroxyapatite (n-HA) was designed, and the effect of n-HA surface-grafted with or without citric acid on in vitro degradation behavior and cells viability was studied by the experiments of soaking in simulated body fluid (SBF) and incubating with human osteoblast-like cells (MG-63). The change of pH value, tensile strength reduction, the surface deposits, cells attachment and proliferation of samples during the soaking and incubation were investigated by means of pH meter, electromechanical universal tester, scanning electron microscope (SEM) coupled with energy-dispersive spectro-scopy (EDS), fluorescence microscope and MTT method...
October 1, 2016: Colloids and Surfaces. B, Biointerfaces
Yingxian Song, Hua Pu, Tian Jiang, Lixin Zhang, Min Ouyang
Glutamate-1-semialdehyde-2,1-aminomutase (GSAM) catalyzes the isomerization of glutamate-1-semialdehyde (GSA) to 5-aminolevulinate (ALA) and is distributed in archaea, most bacteria and plants. Although structures of GSAM from archaea and bacteria have been resolved, a GSAM structure from a higher plant is not available, preventing further structure-function analysis. Here, the structure of GSAM from Arabidopsis thaliana (AtGSA1) obtained by X-ray crystallography is reported at 1.25 Å resolution. AtGSA1 forms an asymmetric dimer and displays asymmetry in cofactor binding as well as in the gating-loop orientation, which is consistent with previously reported Synechococcus GSAM structures...
June 2016: Acta Crystallographica. Section F, Structural Biology Communications
Mingzhi Dai, Karim Khan, Shengnan Zhang, Kemin Jiang, Xingye Zhang, Weiliang Wang, Lingyan Liang, Hongtao Cao, Pengjun Wang, Peng Wang, Lijing Miao, Haiming Qin, Jun Jiang, Lixin Xue, Junhao Chu
Sub-gap density of states (DOS) is a key parameter to impact the electrical characteristics of semiconductor materials-based transistors in integrated circuits. Previously, spectroscopy methodologies for DOS extractions include the static methods, temperature dependent spectroscopy and photonic spectroscopy. However, they might involve lots of assumptions, calculations, temperature or optical impacts into the intrinsic distribution of DOS along the bandgap of the materials. A direct and simpler method is developed to extract the DOS distribution from amorphous oxide-based thin-film transistors (TFTs) based on Dual gate pulse spectroscopy (GPS), introducing less extrinsic factors such as temperature and laborious numerical mathematical analysis than conventional methods...
2016: Scientific Reports
Wei Chi, Jing Li, Baoye He, Xin Chai, Xiumei Xu, Xuwu Sun, Jingjing Jiang, Peiqiang Feng, Jianru Zuo, Rongcheng Lin, Jean-David Rochaix, Lixin Zhang
Cytokinin is an essential phytohormone that controls various biological processes in plants. A number of response regulators are known to be important for cytokinin signal transduction. ARABIDOPSIS RESPONSE REGULATOR 4 (ARR4) mediates the cross-talk between light and cytokinin signaling through modulation of the activity of phytochrome B. However, the mechanism that regulates the activity and stability of ARR4 is unknown. Here we identify an ATP-independent serine protease, degradation of periplasmic proteins 9 (DEG9), which localizes to the nucleus and regulates the stability of ARR4...
June 21, 2016: Proceedings of the National Academy of Sciences of the United States of America
Yanping Tian, Jiarui Xia, Ling Zhang, Junhui Zhang, Yi Jiang, Yao Zhang, Lini Yang, Qian Zhang, Lixin Xia
Polymeric liposomes (denoted as ILs-polysomes) are a biocompatible and conductive nanomaterial, which was first utilised as the electrode material for immobilising and biosensing redox enzyme horseradish peroxide (HRP). The morphology and surface property of IL-polysomes was characterised and systematically compared with unpolymerised ionic liquid based liposomes (denoted as ILs-liposomes). Differing from IL-liposomes, IL-polysomes preserves their original morphology and bilayer membrane structure on glassy carbon (GC) electrodes due to the cross-linking of polymerised lipids, thus exhibiting excellent stability and specific biocompability...
October 2016: Bioelectrochemistry
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