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Lixin Jiang

Lingjie Wu, Zuohua Tang, Xiaoyuan Feng, Xinghuai Sun, Wen Qian, Jie Wang, Lixin Jin, Jingxuan Jiang, Yufeng Zhong
The metabolic changes accompanied with adaptive plasticity in the visual cortex after early monocular visual loss were unclear. In this study, we detected the metabolic changes in bilateral visual cortex of normal (group A) and monocular blind macaque (group B) for studying the adaptive plasticity using multi-voxel proton magnetic resonance spectroscopy ((1)H-MRS) at 32 months after right optic nerve transection. Then, we compared the N-Acetyl aspartate (NAA)/Creatine (Cr), myoinositol (Ins)/Cr, choline (Cho)/Cr and Glx (Glutamate + glutamine)/Cr ratios in the visual cortex between two groups, as well as between the left and right visual cortex of group A and B...
December 1, 2016: Neurochemical Research
Lixin Jiang, Tahira M Probst
Despite the prevalence of income inequality in today's society, research on the implications of income inequality for organizational research is scant. This study takes the first step to explore the contextual role of national- and state- level income inequality as a moderator in the relationship between individual-level job insecurity (JI) and burnout. Drawing from conservation of resource (COR) theory, we argue that income inequality at the country-level and state-level threatens one's obtainment of object (i...
November 28, 2016: Journal of Applied Psychology
Ruchir Srivastava, Lixin Duan, Damon W K Wong, Jiang Liu, Tien Yin Wong
BACKGROUND AND OBJECTIVES: Diabetic Retinopathy is the leading cause of blindness in developed countries in the age group 20-74 years. It is characterized by lesions on the retina and this paper focuses on detecting two of these lesions, Microaneurysms and Hemorrhages, which are also known as red lesions. This paper attempts to deal with two problems in detecting red lesions from retinal fundus images: (1) false detections on blood vessels; and (2) different size of red lesions. METHODS: To deal with false detections on blood vessels, novel filters have been proposed which can distinguish between red lesions and blood vessels...
January 2017: Computer Methods and Programs in Biomedicine
Hanning Liu, Zhengxi Xu, Haiyong Gu, Wenke Li, Wen Chen, Cheng Sun, Kun Zhao, Xiao Teng, Heng Zhang, Lixin Jiang, Shengshou Hu, Zhou Zhou, Zhe Zheng
BACKGROUND: This study was aimed to investigate the clinical relevance between glycoprotein Ia (GPIA) rs1126643C/T polymorphism and the outcome of coronary artery disease after coronary artery bypass graft (CABG) surgery and explore the involved potential mechanisms. METHODS AND RESULTS: We genotyped GPIA rs1126643 polymorphism of 1592 patients who underwent CABG and followed up for a median period of 72.8 months. Patients who are GPIA rs1126643 T-allele carriers have a higher major adverse cardiac or cerebrovascular events risk post-CABG than those who are CC homozygotes (hazard ratio [HR]=1...
November 23, 2016: Journal of the American Heart Association
Lixin Xia, Hairan Zhang, Zhichao Wei, Yi Jiang, Ling Zhang, Jie Zhao, Junhui Zhang, Li Dong, Erni Li, Laurent Ruhlmann, Qian Zhang
Catalytic Janus nanosheets were synthesized using an anion-exchange reaction between heteropolyacids (HPAs) and the modified ionic liquids (ILs) moieties of Janus nanosheets. Their morphologies and surface properties were characterized using SEM, EDS, FTIR and XPS spectra. Because of their inherent Janus structure, the nanosheets exhibited good amphipathic character with ILs and oil to form a stable ILs-in-oil emulsion. Therefore, such Janus nanosheets can be utilized both as emulsifiers and catalysts to perform emulsive desulfurization...
November 23, 2016: Chemistry: a European Journal
Lixin Jiang, Zengwu Yao, Yifei Zhang, Jinchen Hu, Dawei Zhao, Huiyuan Zhai, Xixun Wang, Zhenbin Zhang, Dong Wang
OBJECTIVE: To compare the numbers of positive and total lymph nodes and prognosis in gastric cancer patients whose perigastric lymph node retrieval was performed by surgeons and pathologists. METHODS: We conducted a retrospective analysis of clinical and follow-up data from 1, 056 patients who underwent gastric cancer D2 radical lymph node resection between January 2008 and December 2010 in the Gastrointestinal Surgery Department of Yantai Yuhuangding Hospital. The follow-up ended in December 2015...
October 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
Wen-Lian Wu, Duane A Burnett, John Clader, William J Greenlee, Qin Jiang, Lynn A Hyde, Robert A Del Vecchio, Mary E Cohen-Williams, Lixin Song, Julie Lee, Giuseppe Terracina, Qi Zhang, Amin Nomeir, Eric M Parker, Lili Zhang
In this paper we describe our strategy to improve the aqueous solubility of SCH 900229, a potent PS1-selective γ-secretase inhibitor for the treatment of Alzheimer's disease. Incorporation of ionizable amino groups into the side chain terminal generates water soluble β-aminosulfone analogues of SCH 900229 that maintain robust in vitro potency and in vivo efficacy.
May 7, 2016: Bioorganic & Medicinal Chemistry Letters
Mingzhi Dai, Karim Khan, Shengnan Zhang, Kemin Jiang, Xingye Zhang, Weiliang Wang, Lingyan Liang, Hongtao Cao, Pengjun Wang, Peng Wang, Lijing Miao, Haiming Qin, Jun Jiang, Lixin Xue, Junhao Chu
No abstract text is available yet for this article.
November 2, 2016: Scientific Reports
Xi Li, Jing Li, Frederick A Masoudi, John A Spertus, Zhenqiu Lin, Harlan M Krumholz, Lixin Jiang
OBJECTIVES: As the predominant approach to acute reperfusion for ST segment elevation myocardial infarction (STEMI) in many countries, fibrinolytic therapy provides a relative risk reduction for death of ∼16% across the range of baseline risk. For patients with low baseline mortality risk, fibrinolytic therapy may therefore provide little benefit, which may be offset by the risk of major bleeding. We aimed to construct a tool to determine if it is possible to identify a low-risk group among fibrinolytic therapy-eligible patients...
October 24, 2016: BMJ Open
Mindy K Shoss, Lixin Jiang, Tahira M Probst
Job insecurity is a ubiquitous threat that has been linked to a number of undesirable emotional, cognitive, and behavioral outcomes. Against this backdrop, popular and academic accounts have hailed the ability to bounce back from threats (i.e., resilience) as a crucial competency. We leverage the cognitive-relational model of stress to examine the extent to which resilience (operationalized as both dispositional tendencies and coping strategies) mitigates several negative consequences of job insecurity. We tested the moderating role of resilience in 2 studies...
October 27, 2016: Journal of Occupational Health Psychology
Lei Liang, Xue Yang, Yang Yu, Xiaoyong Li, Yechen Wu, Rongyu Shi, Jinghua Jiang, Lu Gao, Fei Ye, Qiudong Zhao, Rong Li, Lixin Wei, Zhipeng Han
Babao Dan (BBD), a traditional Chinese medicine, has been widely used as a complementary and alternative medicine to treat chronic liver diseases. In this study, we aimed to observe the protective effect of BBD on rat hepatic fibrosis induced by diethylnitrosamine (DEN) and explore it possible mechanism. BBD was administrated while DEN was given. After eight weeks, values of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) indicated that BBD significantly protected liver from damaging by DEN and had no obvious side effect on normal rat livers...
October 20, 2016: Oncotarget
Laura Petitta, Lixin Jiang, Charmine E J Härtel
The present study adds novel knowledge to the literature on emotional contagion (EC), discrete emotions, job burnout, and the management of healthcare professionals by simultaneously considering EC as both a job demand and a job resource with multiple social pathways. Integrating EC into the job demands-resource model, we develop and test a conceptual model wherein multiple stakeholder sources of emotional exchanges (i.e., leaders, colleagues, patients) play a differential role in predicting caregivers' absorption of positive (i...
October 10, 2016: Stress and Health: Journal of the International Society for the Investigation of Stress
Lei Shi, Fengrui Jiang, Bao Li, Lixin Wu
We show that chirality transfer from chiral polyoxometalates to achiral polyoxometalates can occur in aqueous solution with unexpected selectivity of surrounding counterions. In comparison with sodium ions, protonated dimethylammonium counterions play a critical role in shortening the inter-cluster distance, thus promoting the efficiency of chirality transfer.
October 18, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Wanhong Zuo, Liwei Wang, Lixin Chen, Krešimir Krnjević, Rao Fu, Xia Feng, Wen He, Seungwoo Kang, Avi Shah, Alex Bekker, Jiang-Hong Ye
Ethanol's aversive property may limit it's use, but the underlying mechanisms are no well-understood. Emerging evidence suggests a critical role for the lateral habenula (LHb) in the aversive response to various drugs, including ethanol. We previously showed that ethanol enhances glutamatergic transmission and stimulates LHb neurons. GABAergic transmission, a major target of ethanol in many brain regions, also tightly regulates LHb activity. This study assessed the action of ethanol on LHb GABAergic transmission in rat brain slices...
September 25, 2016: Neuropharmacology
Chengyan Wang, Kai Zhao, Rui Zhang, Li Jiang, Rui Wang, Xiaodong Zhang, He Wang, Lixin Jin, Jue Zhang, Xiaoying Wang, Jing Fang
The purpose of this study is to demonstrate the feasibility of dynamic renal R2 /R2 '/R2 * measurements based on a method, denoted psMASE-ME, in which a periodic 180° pulse-shifting multi-echo asymmetric spin echo (psMASE) sequence, combined with a moving estimation (ME) strategy, is adopted. Following approval by the institutional animal care and use committee, a block design of respiratory challenge with interleaved air and carbogen (97% O2 , 3% CO2 ) breathing was employed in nine rabbits. Parametrical R2 /R2 '/R2 * maps were computed and average R2 /R2 '/R2 * values were measured in regions of interest in the renal medulla and cortex...
September 27, 2016: NMR in Biomedicine
Wei Jiang, Qi Wang, Xiaolei Qu, Lixin Wang, Xiaoran Wei, Dongqiang Zhu, Kun Yang
The direct contact between multi-walled carbon nanotubes (MWCNTs) and cell membranes causes membrane disruption, potentially leading to cytotoxicity. However, the role of electrostatic forces and MWCNT properties is still open to debate. In this study, the influences of charge and MWCNT surface defects on membrane disruption were investigated by microscopy and a quartz crystal microbalance with dissipation monitoring (QCM-D). Positively/negatively charged giant unilamellar vesicles (GUVs) and supported lipid bilayers (SLBs) were made as model cell membranes...
September 21, 2016: Science of the Total Environment
Matthew J Johnson, Lixin Jiang
This study examined whether meaningful work may improve one's quality of life outside of the workplace (i.e., work-to-life enrichment). More importantly, we proposed and tested competing hypotheses regarding the role of work engagement in the relationship between meaningful work and work-to-life enrichment. Specifically, we investigated whether work engagement served as a mediator of this relationship, as suggested by the job demands-resources model, or instead a moderator, as suggested by conservation of resources theory...
September 20, 2016: Stress and Health: Journal of the International Society for the Investigation of Stress
Li Ma, Jiang Zhu, Qun Gao, Mario J Rebecchi, Qiang Wang, Lixin Liu
We previously reported that pretreatment with the potent antioxidant TEMPOL improves mitochondrial function and restores preconditioning in the aging heart. Because mitophagy is implicated in cardiac preconditioning and declines with age, this study was designed to investigate how age influences mitophagy in response to preconditioning and whether TEMPOL pretreatment improves it. Old (22-24 months) rats were pretreated with or without 4-week TEMPOL and compared with young (4-6 months) untreated rats. Cardioprotection induced by isoflurane (ISO) in vivo and in isolated cardiomyocytes in vitro was assessed following ischemia/reperfusion and simulated hypoxia/reoxygenation, respectively...
August 26, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Chenfei Rao, Junzhe Du, Xi Li, Jing Li, Heng Zhang, Yan Zhao, Shengshou Hu, Lixin Jiang, Zhe Zheng
OBJECTIVES: The benefits of secondary preventive drugs after coronary artery bypass grafting have been thoroughly established. However, the prescription rates of these drugs are low at discharge in China. We sought to evaluate the effectiveness of continuous quality improvement with mobile-based interventions for clinicians on improving the guideline-adherence of secondary preventive drugs prescription. METHODS AND RESULTS: The quality MISSION-1 study is a cluster-randomized controlled trial...
August 2016: American Heart Journal
Daoyang Sun, Xinguo Zhang, Shaohua Li, Cai-Zhong Jiang, Yanlong Zhang, Lixin Niu
The L. regale ATP-binding cassette transporter gene, LrABCF1 belonging to GCN subfamily, functions as a positive regulator of plant defense against Cucumber mosaic virus, Tobacco rattle virus , and Botrytis cinerea in petunia. ATP-binding cassette (ABC) transporters are essential for membrane translocation in diverse biological processes, such as plant development and defense response. Here, a general control non-derepressible (GCN)-type ABC transporter gene, designated LrABCF1, was identified from Cucumber mosaic virus (CMV)-induced cDNA library of L...
December 2016: Planta
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