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Lixin Jiang

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https://www.readbyqxmd.com/read/28936164/sodium-arsenite-induced-learning-and-memory-impairment-is-associated-with-endoplasmic-reticulum-stress-mediated-apoptosis-in-rat-hippocampus
#1
Hongna Sun, Yanmei Yang, Hanwen Shao, Weiwei Sun, Muyu Gu, Hui Wang, Lixin Jiang, Lisha Qu, Dianjun Sun, Yanhui Gao
Chronic arsenic exposure has been associated to cognitive deficits. However, mechanisms remain unknown. The present study investigated the neurotoxic effects of sodium arsenite in drinking water over different dosages and time periods. Based on results from the Morris water maze (MWM) and morphological analysis, an exposure to sodium arsenite could induce neuronal damage in the hippocampus, reduce learning ability, and accelerate memory impairment. Sodium arsenite significantly increased homocysteine levels in serum and brain...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28915656/patterns-and-clinical-significance-of-cervical-lymph-node-metastasis-in-papillary-thyroid-cancer-patients-with-delphian-lymph-node-metastasis
#2
Guibin Zheng, Hua Zhang, Shaolong Hao, Chengxin Liu, Jie Xu, Jinyao Ning, Guochang Wu, Lixin Jiang, Guojun Li, Haitao Zheng, Xicheng Song
Although the roles of Delphian lymph node (DLN) metastasis in papillary thyroid cancer (PTC) have been previously reported, there are still limited data on correlations of clinicopathologic factors with DLN metastasis and unique patterns of cervical node subsite metastasis in PTC patients with DLN metastasis. We retrospectively reviewed medical records of 320 patients with a diagnosis of PTC who underwent primary surgery. Clinicopathologic features and DLN metastasis patterns were analyzed for predicting extensive cervical lymph node metastasis...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28900994/-analysis-of-gastric-gastrointestinal-stromal-tumors-in-shandong-province-a-midterm-report-of-multicenter-gissg1201-study
#3
Qingsheng Hou, Wenqiang Luo, Leping Li, Yong Dai, Lixin Jiang, Ailiang Wang, Xianqun Chu, Yuming Li, Daogui Yang, Chunlei Lu, Linguo Yao, Gang Cui, Huizhong Lin, Gang Chen, Qing Cui, Huanhu Zhang, Zengjun Lun, Lijian Xia, Yingfeng Su, Guoxin Han, Xizeng Hui, Zhixin Wei, Zuocheng Sun, Hongliang Guo, Yanbing Zhou
OBJECTIVE: To summarize the treatment status of gastric gastrointestinal stromal tumor (GIST) in Shandong province,by analyzing the clinicopathological features and prognostic factors. METHODS: Clinicopathological and follow-up data of 1 165 patients with gastric GIST between January 2000 and December 2013 from 23 tertiary referral hospitals in Shandong Province were collected to establish a database. The risk stratification of all cases was performed according to the National Institutes of Health(NIH) criteria proposed in 2008...
September 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28899348/cesarean-section-to-prevent-mother-to-child-transmission-of-hepatitis-b-virus-in-china-a-meta-analysis
#4
Mei Yang, Qin Qin, Qiong Fang, Lixin Jiang, Shaofa Nie
BACKGROUND: Hepatitis B virus (HBV) is predominantly transmitted through mother-to-child transmission (MTCT). To date, it remains unclear whether the method of parturition affects MTCT of HBV. In order to clarify whether cesarean section, when compared with vaginal delivery, could reduce the risk of MTCT of HBV in China, we conducted this meta-analysis. METHODS: A systematic literature search was performed of the PubMed (Medline), Embase, ISI Web of Science, China Biological Medicine Database, China National Knowledge Infrastructure, and VIP Database for Chinese Technical Periodicals databases for articles written in English or Chinese through July 2015...
September 12, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28878172/dietary-protein-consumption-and-the-risk-of-type-2-diabetes-a-systematic-review-and-meta-analysis-of-cohort-studies
#5
Shuang Tian, Qian Xu, Ruyue Jiang, Tianshu Han, Changhao Sun, Lixin Na
Recently, some studies have focused on the relationship between dietary protein intake and the risk of type 2 diabetes mellitus (T2DM), but the conclusions have been inconsistent. Therefore, in this paper, a systematic review and meta-analysis of cohort studies regarding protein consumption and T2DM risk are conducted in order to present the association between them. We searched the PubMed and Embase databases for cohort studies on dietary protein, high-protein food consumption and risk of T2DM, up to July 2017...
September 6, 2017: Nutrients
https://www.readbyqxmd.com/read/28871270/in-vivo-assembly-in-escherichia-coli-of-transformation-vectors-for-plastid-genome-engineering
#6
Yuyong Wu, Lili You, Shengchun Li, Meiqi Ma, Mengting Wu, Lixin Ma, Ralph Bock, Ling Chang, Jiang Zhang
Plastid transformation for the expression of recombinant proteins and entire metabolic pathways has become a promising tool for plant biotechnology. However, large-scale application of this technology has been hindered by some technical bottlenecks, including lack of routine transformation protocols for agronomically important crop plants like rice or maize. Currently, there are no standard or commercial plastid transformation vectors available for the scientific community. Construction of a plastid transformation vector usually requires tedious and time-consuming cloning steps...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28851781/protocol-for-a-nationwide-survey-of-primary-health-care-in-china-the-china-peace-patient-centered-evaluative-assessment-of-cardiac-events-mpp-million-persons-project-primary-health-care-survey
#7
Meng Su, Qiuli Zhang, Jiapeng Lu, Xi Li, Na Tian, Yun Wang, Winnie Yip, Kar Keung Cheng, George A Mensah, Ralph I Horwitz, Elias Mossialos, Harlan M Krumholz, Lixin Jiang
INTRODUCTION: China has pioneered advances in primary health care (PHC) and public health for a large and diverse population. To date, the current state of PHC in China has not been subjected to systematic assessments. Understanding variations in primary care services could generate opportunities for improving the structure and function of PHC. METHODS AND ANALYSIS: This paper describes a nationwide PHC study (PEACE MPP Primary Health Care Survey) conducted across 31 provinces in China...
August 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/28819452/co-activation-of-pkc-%C3%AE-by-crif1-modulates-oxidative-stress-in-bone-marrow-multipotent-mesenchymal-stromal-cells-after-irradiation-by-phosphorylating-nrf2-ser40
#8
Lili Chen, Qian Ran, Yang Xiang, Lixin Xiang, Li Chen, Fengjie Li, Jiang Wu, Chun Wu, Zhongjun Li
The high mortality associated with pancytopenia and multi-organ failure resulting from hematopoietic disorders of acute radiation syndrome (h-ARS) creates an urgent need for developing more effective treatment strategies. Here, we showed that bone marrow multipotent mesenchymal stromal cells (BMMSCs) effectively regulate oxidative stress following radiative injury, which might be on account of irradiation-induced elevation of protein levels of CR6-interacting factor 1(CRIF1) and nuclear factor E2-related factor 2(NRF2)...
2017: Theranostics
https://www.readbyqxmd.com/read/28810653/surgical-trauma-and-low-dose-methylprednisolone-modulate-the-severity-of-the-acute-phase-response-induced-by-zoledronic-acid-infusion
#9
Jian Chen, Lipeng Yu, Lixin Chen, Xuan Wu, Pengyu Tang, Jian Yin, Tao Jiang, Guoyong Yin, Jin Fan
The aim of the present study was to investigate risk factors for the development of an acute-phase response (APR) associated with the initial zoledronic acid (ZA) infusion in patients undergoing surgery, and to assess whether its onset may be reduced by post-dose administration of low-dose methylprednisolone (MP) or acetaminophen. A retrospective study of patients with osteoporosis who attended the departments of orthopedics and endocrinology of a single hospital and received 5 mg ZA was conducted; the patients included surgical and non-surgical cases...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28808071/temporal-relationship-between-hyperuricemia-and-insulin-resistance-and-its-impact-on-future-risk-of-hypertension
#10
Tianshu Han, Li Lan, Rongge Qu, Qian Xu, Ruyue Jiang, Lixin Na, Changhao Sun
Although hyperuricemia and insulin resistance significantly correlated, their temporal sequence and how the sequence influence on future risk of hypertension are largely unknown. This study assessed temporal relationship between uric acid and insulin resistance and its impact on future risk of hypertension by examining a longitudinal cohort including 8543 subjects aged 20 to 74 years from China, with an average follow-up of 5.3 years. Measurements of fasting uric acid, as well as fasting and 2-hour serum glucose and insulin, were obtained at baseline and follow-up...
August 14, 2017: Hypertension
https://www.readbyqxmd.com/read/28763670/association-between-chronic-exposure-to-different-water-iodine-and-thyroid-cancer-a-retrospective-study-from-1995-to-2014
#11
Chunpeng Lv, Yanmei Yang, Lixin Jiang, Lin Gao, Shengzhong Rong, Gottfried M Darko, Wen Jiang, Yanhui Gao, Dianjun Sun
The controversy that iodine intake may increase the risk of thyroid cancer has heightened over the past twenty years. In this retrospective study, we mainly analyzed the association between water iodine and thyroid cancer and discussed the possible cause of the increase in thyroid cancer. This study was supported by three hospitals in areas with different water iodine concentration. 5574 patients with thyroid disease were recruited, of which 1429 patients had been diagnosed with thyroid cancer. These samples collectively were used to analyze the relationship of incidence and prevalence associated with water iodine...
December 31, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28739752/severe-cardiotoxicity-in-a-patient-with-colorectal-cancer-treated-with-bevacizumab
#12
Jian Chen, Fengcai Du, Baohong Hu, Cheng Chi, Hongjin Chu, Lixin Jiang, Peng Li, Zhaohua Gong
BACKGROUND/AIM: Bevacizumab combined with standard chemotherapeutics has become a choice of treatment for several kinds of cancers. Hypertension, third-degree albuminuria, thrombosis and cardiotoxicity are the reported side-effects of bevacizumab. Among them, cardiotoxicity is a most severe, but rare outcome. We report a case of a 62-year-old female with colorectal carcinoma who was given bevacizumab-containing chemotherapy for more than 20 months and achieved a stable disease during the entire course of treatment...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739742/expression-and-significance-of-cyclophilin-j-in-primary-gastric-adenocarcinoma
#13
Zhaohua Gong, Yuling Mu, Jian Chen, Hongjin Chu, Peiwen Lian, Congcong Wang, Jiahui Wang, Lixin Jiang
BACKGROUND/AIM: Biomarkers are essential in early diagnosis and understanding of the molecular mechanism of human cancer. The expression of cyclophilin J, a novel member of the cyclophilin family, was investigated in primary gastric adenocarcinoma. MATERIALS AND METHODS: Western blot analysis was carried out on 36 paired tumor and normal tissue samples; immunohistochemical analysis was carried out on 120 gastric carcinoma tissues and normal adjacent tissue. RESULTS: Cyclophilin J protein was overexpressed in 72...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739738/cyclophilin-a-is-overexpressed-in-hepatocellular-carcinoma-and-is-associated-with-the-cell-cycle
#14
Zhaohua Gong, Cheng Chi, Xiaojuan Huang, Hongjin Chu, Jiahui Wang, Fengcai Du, Lixin Jiang, Jian Chen
AIM: To investigate the expression of cyclophilin A (CypA) in human hepatocellular carcinoma (HCC) and explore the effects of CypA on the cell cycle in HCC. MATERIALS AND METHODS: CypA expression was assessed by immunohistochemistry in 48 cases of HCC tissues and paired adjacent tissues. CypA plasmid was transfected into HCC cells and the cell cycle was analyzed. RESULTS: Positivity for CypA was higher in HCC tissues than in adjacent tissues (79...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28716525/peri-tumor-associated-fibroblasts-promote-intrahepatic-metastasis-of-hepatocellular-carcinoma-by-recruiting-cancer-stem-cells
#15
Jinghua Jiang, Fei Ye, Xue Yang, Chen Zong, Lu Gao, Yang Yang, Qiudong Zhao, Zhipeng Han, Lixin Wei
Fibroblasts have been reported to play an important role in hepatocellular carcinoma (HCC). However, the role of fibroblasts have not been fully understood. Conditioned medium collected from human peri-tumor tissue-derived fibroblasts (CM-pTAFs) showed high metastasis ability than human HCC tissues-derived fibroblasts (CM-TAFs). To determine what component was secreted from fibroblasts, we used Bio-Plex analysis system and compared the factors secreted from CM-pTAFs and CM-TAFs, found a series of up-regulated cytokines in the CM-pTAFs, including IL-6, CCL2, CXCL1, CXCL8, SCGF-β, HGF and VEGF...
September 28, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28711904/patterns-and-clinical-significance-of-cervical-lymph-node-metastasis-in-papillary-thyroid-cancer-patients-with-delphian-lymph-node-metastasis
#16
Guibin Zheng, Hua Zhang, Shaolong Hao, Chengxin Liu, Jie Xu, Jinyao Ning, Guochang Wu, Lixin Jiang, Guojun Li, Haitao Zheng, Xicheng Song
Although the roles of Delphian lymph node (DLN) metastasis in papillary thyroid cancer (PTC) have been previously reported, there are still limited data on correlations of clinicopathologic factors with DLN metastasis and unique patterns of cervical node subsite metastasis in PTC patients with DLN metastasis. We retrospectively reviewed medical records of 320 patients with a diagnosis of PTC who underwent primary surgery. Clinicopathologic features and DLN metastasis patterns were analyzed for predicting extensive cervical lymph node metastasis...
July 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28691775/short-peptides-directing-1d-helical-arrays-of-polyoxometalates-with-controllable-pitches
#17
Jingfang Li, Xiangyi Li, Fengrui Jiang, Xiaodong Li, Xiaoming Xie, Lixin Wu, Liyan Wang, Myongsoo Lee, Wen Li
A series of cationic peptides with alternating hydrophilic and hydrophobic residues were elaborately designed and synthesized. These kinds of short peptides with protonated lysine groups can interact with anionic polyoxometalate nanoclusters through multivalent ionic bonds and hydrogen bonds, resulting in the formation of helical polyoxometalate arrays in aqueous solution. Fourier transform infrared (FTIR) spectroscopy, circular dichroism (CD), transmission electron microscopy (TEM), and dynamic light scattering (DLS) were utilized to characterize the self-assembled structures...
July 10, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28645937/quality-of-care-in-chinese-hospitals-processes-and-outcomes-after-st-segment-elevation-myocardial-infarction
#18
Nicholas S Downing, Yongfei Wang, Kumar Dharmarajan, Sudhakar V Nuti, Karthik Murugiah, Xue Du, Xin Zheng, Xi Li, Jing Li, Frederick A Masoudi, John A Spertus, Lixin Jiang, Harlan M Krumholz
BACKGROUND: China has gaps in the quality of care provided to patients with ST-elevation myocardial infarction, but little is known about how quality varies between hospitals. METHODS AND RESULTS: Using nationally representative data from the China PEACE-Retrospective AMI Study, we characterized the quality of care for ST-elevation myocardial infarction at the hospital level and examined variation between hospitals. Two summary measures were used to describe the overall quality of care at each hospital and to characterize variations in quality between hospitals in 2001, 2006, and 2011...
June 23, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28618398/correlation-of-thyroid-stimulating-hormone-receptor-mrna-expression-levels-in-peripheral-blood-with-undesirable-clinicopathological-features-in-papillary-thyroid-carcinoma-patients
#19
Riming Liu, Shaolong Hao, Hua Zhang, Jihong Ma, Xincheng Liu, Jie Xu, Xin Liu, Jinyao Ning, Yan Sun, Lixin Jiang, Guojun Li, Xicheng Song, Haitao Zheng
To determine the extent to which thyroid stimulating hormone receptor (TSHR) mRNA in peripheral blood (PB) has diagnostic value for papillary thyroid carcinoma (PTC). We obtained pre- and postoperative PB samples from 104 thyroid disease patients and collected 11 healthy volunteers' PB samples twice apiece at different times. We used reverse transcription polymerase chain reaction (RT-PCR) to quantify TSHR mRNA expression levels in the samples. T-test and chi-square test were used to compare quantitative data and rates...
May 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/28612952/a-nanoparticle-decorated-biomolecule-responsive-polymer-enables-robust-signaling-cascade-for-biosensing
#20
Zuan-Tao Lin, Jianhua Gu, Chien-Hung Li, T Randall Lee, Lixin Xie, Shuo Chen, Piao-Yang Cao, Shan Jiang, Yulin Yuan, Xia Hong, Hongting Wang, Dezhi Wang, Xifan Wang, Gang-Biao Jiang, Mikala Heon, Tianfu Wu
To meet the increasing demands for ultrasensitivity in monitoring trace amounts of low-abundance early biomarkers or environmental toxins, the development of a robust sensing system is urgently needed. Here, a novel signal cascade strategy is reported via an ultrasensitive polymeric sensing system (UPSS) composed of gold nanoparticle (gNP)-decorated polymer, which enables gNP aggregation in polymeric network and electrical conductance change upon specific aptamer-based biomolecular recognition. Ultralow concentrations of thrombin (10(-18) m) as well as a low molecular weight anatoxin (165 Da, 10(-14) m) are detected selectively and reproducibly...
June 14, 2017: Advanced Materials
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