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https://www.readbyqxmd.com/read/29779758/assessing-venous-thrombus-in-renal-cell-carcinoma-preliminary-results-for-unenhanced-3d-ssfp-mri
#1
L C Adams, B Ralla, G Engel, G Diederichs, B Hamm, J Busch, F Fuller, M R Makowski
AIM: To test the potential of unenhanced cardiac- and respiratory-motion-corrected three-dimensional steady-state free precession (3D-SSFP) magnetic resonance imaging (MRI) for the assessment of inferior vena cava (IVC) thrombus in patients with clear-cell renal cell carcinoma (cRCC), compared to standard contrast-enhanced (CE)-MRI and CE-computed tomography (CT). MATERIALS AND METHODS: Eighteen patients with cRCC and IVC thrombus, who received CE-MRI and 3D-SSFP at 1...
May 17, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29770800/current-and-future-circulating-biomarkers-for-cardiac-amyloidosis
#2
REVIEW
Marco Luciani, Luca Troncone, Federica Del Monte
Cardiac amyloidosis (CA) comprises a heterogeneous group of medical conditions affecting the myocardium. It presents with proteinaceous infiltration with variable degrees of severity, prevalence and evolution. Despite this heterogeneity, erroneous protein folding is the common pathophysiologic process, yielding the formation of a single misfolded protein (monomer) that progressively evolves and ultimately forms amyloid fibers. Additionally, by seeding out from the organs of origin, intermediates called oligomers metastasize and restart the process...
May 17, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29753425/-the-contribution-of-systematic-implementation-of-cardiovascular-explorations-for-the-detection-of-cardiac-sources-of-embolism-in-patients-with-stroke-about-230-patients
#3
A Hadi, L Bendriss, A Khatouri
OBJECTIVES: Ischemic stroke are estimated at 80% of all strokes. Embolism of cardiac origin accounts for around 20% of them. The aim of our study is to report the contribution of cardiovascular investigations performed as a routine during the evaluation of patients with ischemic stroke. PATIENTS AND METHODS: This is a retrospective study of ischemic stroke cases collated in Cardiology department of the military hospital of Marrakech between January 2010 and December 2014...
May 9, 2018: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/29746007/preterm-growth-restriction-and-bronchopulmonary-dysplasia-the-vascular-hypothesis-and-related-physiology
#4
Arvind Sehgal, Stella M Gwini, Samuel Menahem, Beth J Allison, Suzanne L Miller, Graeme R Polglase
KEY POINTS: Approximately 5-10% pregnancies are affected by fetal growth restriction. Preterm infants affected by fetal growth restriction have a higher incidence of bronchopulmonary dysplasia. This study is the first to measure pulmonary artery thickness and stiffness. It highlights that impaired vasculogenesis may be a contributory factor in the higher incidence of bronchopulmonary dysplasia in preterm growth restricted infants. The study addresses the mechanistic link between fetal programming and vascular architecture and mechanics...
May 10, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29745607/-characteristics-of-the-inferior-wall-hypertrophy-in-hypertrophic-cardiomyopathy-patients-with-contrast-echocardiography
#5
Zhiyue Liu, Wen Zhang, Xianchao Jing, Lei Xiao, He Huang
We tried to explore the value of contrast echocardiography (CEcho) on evaluating hypertrophic cardiomyopathy (HCM) with the inferior wall hypertrophy. A total of 114 patients with HCM were investigated. All the patients received CEcho and routine echocardiography (Echo), and 45 of them received cardiac magnetic resonance (CMR) and 47 of them received Holter. The frequency and percentage of inferior wall hypertrophy were analyzed in HCM patients, as well as the structure and function. The results showed that: (1) Inferior wall hypertrophy was detected in 55 patients (48%) by Echo, while 68 patients (60%) by CEcho...
February 1, 2018: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29721914/echocardiography-in-arterial-hypertension
#6
REVIEW
Giovanni de Simone, Costantino Mancusi, Roberta Esposito, Nicola De Luca, Maurizio Galderisi
Hypertension is a condition characterized by pressure and/or volume overloads and echocardiography is helpful and feasible to understand hemodynamic mechanisms. Echocardiographic information is sometimes critical and susceptible of modifying decision making. In this review, we provide detailed descriptions of the parameters that can be derived from a standard transthoracic echocardiogram, including some more recent techniques. We will also explain how each parameter might have impact in the evaluation of the hypertensive patient and give indications on when to refer patients to echo-labs, which parameters are critical and which ones might be redundant, and how to use the information obtained in the report...
May 2, 2018: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/29713052/predictors-of-diastolic-dysfunction-in-ethnic-groups-observations-from-the-hypertensive-cohort-of-the-ethnic-echocardiographic-heart-of-england-screening-study-e-echoes
#7
Alena Shantsila, Eduard Shantsila, Paramjit S Gill, Gregory Y H Lip
The study aimed to establish a relationship of ethnicity to diastolic dysfunction in subjects of African-Caribbean and South Asian origins and the impact of diastolic dysfunction and ethnicity on all-cause and cardiovascular mortality. Hypertensive subjects with ejection fraction ≥55% and no history of ischaemic heart disease/valve pathology (n  =  1546, 830 South Asians and 716 African-Caribbeans) were identified from the Ethnic-Echocardiographic Heart of England Screening Study (E-ECHOES). Diastolic function and cardiac remodelling were measured by echocardiography...
May 1, 2018: Journal of Human Hypertension
https://www.readbyqxmd.com/read/29700783/modeling-right-ventricle-failure-after-continuous-flow-left-ventricular-assist-device-a-biventricular-finite-element-and-lumped-parameter-analysis
#8
Francesco Scardulla, Valentina Agnese, Giuseppe Romano, Gabriele Di Gesaro, Sergio Sciacca, Diego Bellavia, Francesco Clemenza, Michele Pilato, Salvatore Pasta
The risk of right ventricle (RV) failure remains a major contraindication for continuous-flow left ventricular assist device (CF-LVAD) implantation in patients with heart failure. It is therefore critical to identify the patients who will benefit from early intervention to avoid adverse outcomes. We sought to advance the computational modeling description of the mechanisms underlying RV failure in LVAD-supported patients. RV failure was studied by computational modeling of hemodynamic and cardiac mechanics using lumped-parameter and biventricular finite element (FE) analysis...
April 26, 2018: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/29699498/prediction-of-clinical-outcome-in-patients-treated-with-cardiac-resynchronization-therapy-the-role-of-nt-probnp-and-a-combined-response-score
#9
Z Bakos, N C Chatterjee, C Reitan, J P Singh, R Borgquist
BACKGROUND: Cardiac resynchronization therapy (CRT) is an established therapy for appropriately selected patients with heart failure. Response to CRT has been heterogeneously defined using both clinical and echocardiographic measures, with poor correlation between the two. METHODS: The study cohort was comprised of 202 CRT-treated patients and CRT response was defined at 6 months post-implant. Echocardiographic response (E+) was defined as a reduction in LVESV ≥ 15%, clinical response as an improvement of ≥ 1 NYHA class (C+), and biomarker response as a ≥ 25% reduction in NT-proBNP(B+)...
April 24, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29693936/cardiac-point-of-care-using-ultrasound
#10
Mitsuharu Kodaka
Patients with cardiac disease have high mortality rates, mainly owing to shock. Therefore, evaluation of cardiac function is one of the most challenging issues in the intensive and critical care unit. Cardiac point-of-care tests using ultrasound, such as focus assessed transthoracic echo (FATE) and rapid ultrasound in shock (RUSH). are useful for diagnosis and initial care of such patients. The author will introduce first a basic FATE protocol of how to scan from position 1-4, including subcostal 4-chamber, apical 4-chamber, parasternal long and short axis, and pleural scanning...
May 2017: Masui. the Japanese Journal of Anesthesiology
https://www.readbyqxmd.com/read/29691224/echo-and-heart-failure-when-do-people-need-an-echo-and-when-do-they-need-natriuretic-peptides
#11
REVIEW
Daniel Modin, Ditte Madsen Andersen, Tor Biering-Sørensen
Heart failure (HF) is a threat to public health. Heterogeneities in etiology and phenotype complicate the diagnosis and management of HF. This is especially true when considering HF with preserved ejection fraction (HFpEF) which make up 50% of HF cases. Natriuretic peptides may aid in establishing a working diagnosis in patients suspected of HF, but echocardiography remains the optimal choice for diagnosing HF. Echocardiography provides important prognostic information in both HF with reduced ejection fraction (HFrEF) and HFpEF...
April 24, 2018: Echo Research and Practice
https://www.readbyqxmd.com/read/29688154/use-of-myocardial-t1-mapping-at-3-0-t-to-differentiate-anderson-fabry-disease-from-hypertrophic-cardiomyopathy
#12
Gauri R Karur, Sean Robison, Robert M Iwanochko, Chantal F Morel, Andrew M Crean, Paaladinesh Thavendiranathan, Elsie T Nguyen, Shobhit Mathur, Syed Wasim, Kate Hanneman
Purpose To compare left ventricular (LV) and right ventricular (RV) 3.0-T cardiac magnetic resonance (MR) imaging T1 values in Anderson-Fabry disease (AFD) and hypertrophic cardiomyopathy (HCM) and evaluate the diagnostic value of native T1 values beyond age, sex, and conventional imaging features. Materials and Methods For this prospective study, 30 patients with gene-positive AFD (37% male; mean age ± standard deviation, 45.0 years ± 14.1) and 30 patients with HCM (57% male; mean age, 49.3 years ± 13.5) were prospectively recruited between June 2016 and September 2017 to undergo cardiac MR imaging T1 mapping with a modified Look-Locker inversion recovery (MOLLI) acquisition scheme at 3...
April 24, 2018: Radiology
https://www.readbyqxmd.com/read/29686796/rapidly-progressive-dyspnea-in-gastrointestinal-stromal-tumor-gist-with-imatinib-cardiac-toxicity
#13
Adnan Asif Parvez Ghias, Shahzeem Bhayani, David J Gemmel, Sudershan K Garg
Gastrointestinal stromal tumors (GISTs) are rare and current estimates range from 4,000 to 6,000 number of GIST cases in the USA annually. Imatinib, a tyrosine kinase inhibitor, has shown a survival benefit in GISTs, and the presence of KIT mutation status is predictive of response. The current case discusses rapidly progressive dyspnea and heart failure in an elderly male with metastatic GIST who was started on imatinib. Although reported as a rare and sporadic side effect of imatinib, the current case illustrates rapidity and the clinical significance of cardiotoxicity, with onset at 2 weeks...
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29678322/measurement-of-wall-shear-stress-exerted-by-flowing-blood-in-the-human-carotid-artery-ultrasound-doppler-velocimetry-and-echo-particle-image-velocimetry
#14
Phillip E Gates, Arati Gurung, Luciano Mazzaro, Kuni Aizawa, Salim Elyas, William D Strain, Angela C Shore, Robin Shandas
Vascular endothelial cells lining the arteries are sensitive to wall shear stress (WSS) exerted by flowing blood. An important component of the pathophysiology of vascular diseases, WSS is commonly estimated by centerline ultrasound Doppler velocimetry (UDV). However, the accuracy of this method is uncertain. We have previously validated the use of a novel, ultrasound-based, particle image velocimetry technique (echo PIV) to compute 2-D velocity vector fields, which can easily be converted into WSS data. We compared WSS data derived from UDV and echo PIV in the common carotid artery of 27 healthy participants...
April 17, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29677191/type-2-diabetic-aldehyde-dehydrogenase-2-mutant-mice-aldh-2-2-exhibiting-heart-failure-with-preserved-ejection-fraction-phenotype-can-be-determined-by-exercise-stress-echocardiography
#15
Guodong Pan, Srikar Munukutla, Ananya Kar, Joseph Gardinier, Rajarajan A Thandavarayan, Suresh Selvaraj Palaniyandi
E487K point mutation of aldehyde dehydrogenase (ALDH) 2 (ALDH2*2) in East Asians intrinsically lowers ALDH2 activity. ALDH2*2 is associated with diabetic cardiomyopathy. Diabetic patients exhibit heart failure of preserved ejection fraction (HFpEF) i.e. while the systolic heart function is preserved in them, they may exhibit diastolic dysfunction, implying a jeopardized myocardial health. Currently, it is challenging to detect cardiac functional deterioration in diabetic mice. Stress echocardiography (echo) in the clinical set-up is a procedure used to measure cardiac reserve and impaired cardiac function in coronary artery diseases...
2018: PloS One
https://www.readbyqxmd.com/read/29669563/a-comparison-of-both-dense-and-feature-tracking-techniques-with-tagging-for-the-cardiovascular-magnetic-resonance-assessment-of-myocardial-strain
#16
J Jane Cao, Nora Ngai, Lynette Duncanson, Joshua Cheng, Kathleen Gliganic, Qizhi Chen
BACKGROUND: Myocardial strain is increasingly recognized as an important assessment for myocardial function. In addition, it also improves outcome prediction. However, there is lack of standardization in strain evaluation by cardiovascular magnetic resonance (CMR). In this study we compared strain values using multiple techniques and multiple vendor products. METHODS: Prospectively recruited patients with cardiomyopathy of diverse etiology (N = 77) and healthy controls (N = 10) underwent CMR on a 1...
April 19, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29665845/deletion-of-hp1%C3%AE-in-cardiac-myocytes-affects-h4k20me3-levels-but-does-not-impact-cardiac-growth
#17
Kyohei Oyama, Danny El-Nachef, Chen Fang, Hidemi Kajimoto, Jeremy P Brown, Prim B Singh, W Robb MacLellan
BACKGROUND: Heterochromatin, which is formed when tri-methyl lysine 9 of histone H3 (H3K9me3) is bound by heterochromatin 1 proteins (HP1s), plays an important role in differentiation and senescence by silencing cell cycle genes. Cardiac myocytes (CMs) accumulate heterochromatin during differentiation and demethylation of H3K9me3 inhibits cell cycle gene silencing and cell cycle exit in CMs; however, it is unclear if this process is mediated by HP1s. In this study, we created a conditional CM-specific HP1 gamma (HP1γ) knockout (KO) mouse model and tested whether HP1γ is required for cell cycle gene silencing and cardiac growth...
April 17, 2018: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/29650397/assessment-of-five-different-probes-for-lung-ultrasound-in-critically-ill-patients-a-pilot-study
#18
Xavier Bobbia, Margaux Chabannon, Thierry Chevallier, Jean Emmanuel de La Coussaye, Jean Yves Lefrant, Sarah Pujol, Pierre-Géraud Claret, Laurent Zieleskiewicz, Claire Roger, Laurent Muller
INTRODUCTION: The present study was aimed at comparing the diagnosis concordance of five echo probes of lung ultrasound (LUS) with CT scans in intensive care and emergency patients with acute respiratory failure. MATERIALS: This prospective, observational, pilot study involved 10 acute patients in whom a thoracic CT scan was performed. An expert performed an LUS reference exam using five different probes: three probes with a high-quality conventional echo machine (cardiac phased-array probe, abdominal convex probe, linear probe) and two probes (cardiac and linear) with a pocket ultrasound device (PUD)...
April 3, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29643879/transesophageal-echocardiography-in-cardiogenic-embolic-cerebral-infarction
#19
Wen Chu, Hua Wang
Objective: To evaluate the diagnostic values of transesophageal echocardiography (TEE) and transthoracic echocardiography (TTE) in cardiogenic embolic cerebral infarction. Methods: Fifty patients with occult cerebral infarction who were admitted to the hospital between June 2015 and June 2016 were selected as research subjects. The patients were diagnosed by transesophageal echocardiography and transthoracic echocardiography. Diagnostic data were compared to analyze the values of the two diagnostic methods...
January 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29627182/transesophageal-echocardiographic-strain-imaging-predicts-aortic-biomechanics-beyond-diameter
#20
Alexander Emmott, Haitham Alzahrani, Mohammed Alreishidan, Judith Therrien, Richard L Leask, Kevin Lachapelle
BACKGROUND: Clinical guidelines recommend resection of ascending aortic aneurysms at diameters 5.5 cm or greater to prevent rupture or dissection. However, approximately 40% of all ascending aortic dissections occur below this threshold. We propose new transesophageal echocardiography strain-imaging moduli coupled with blood pressure measurements to predict aortic dysfunction below the surgical threshold. METHODS: A total of 21 patients undergoing aortic resection were recruited to participate in this study...
March 11, 2018: Journal of Thoracic and Cardiovascular Surgery
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