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https://www.readbyqxmd.com/read/29349525/value-of-ct-pulmonary-angiography-to-predict-short-term-outcome-in-patient-with-pulmonary-embolism
#1
Ahmed M Osman, Emad H Abdeldayem
To evaluate the role of CT pulmonary angiography (CTPA) in the assessment of pulmonary embolism (PE) severity and the related CT cardiac changes, reflecting the clinical status of the patients and predicting the outcome. A prospective study of 184 patients presented with suspicious acute PE. All patients underwent CTPA followed by ECHO. Pulmonary artery obstructive index (PAOI) using Qanadli Score was calculated and cardiac changes recorded. The patients' outcome was followed up for 30 days. Only 150 patients completed the study; 26...
January 18, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29346710/an-extensive-caseous-calcification-of-the-mitral-annulus-complicated-with-severe-mitral-regurgitation
#2
Alper Karakus, Hakan Tibilli, Ibrahim H Inanc, Hakan Tasolar, Serdar Turkmen, Erdal Akturk
Caseous calcification of the mitral annulus (CCMA) is considered a rare variant of mitral annular calcification (MAC) due to caseous transformation of the inner material and prevalence of CCMA, about 0.63% of all MAC cases and 0.06%-0.07% of the population. The precise pathophysiology of CCMA is still unknown. It is a chronic degenerative disorder common in the elderly, particularly in women. Caseous calcification of the mitral annulus (CCMA) is a soft peri-annular extensive calcification, resembling cardiac tumors, abscesses, vegetation, or calcified thrombus, which is composed of an admixture of calcium, fatty acids, and cholesterol with a toothpaste-like texture...
January 18, 2018: Echocardiography
https://www.readbyqxmd.com/read/29327374/dynamic-coronary-mr-angiography-in-a-pig-model-with-hyperpolarized-water
#3
Kasper Wigh Lipsø, Esben Søvsø Szocska Hansen, Rasmus Stilling Tougaard, Christoffer Laustsen, Jan Henrik Ardenkjaer-Larsen
PURPOSE: To investigate dynamic coronary MR angiography using hyperpolarized water as a positive contrast agent. Hyperpolarization can increase the signal by several orders of magnitude, and has recently been translated to human cardiac application. The aim was to achieve large 1 H signal enhancement to allow high-resolution imaging of the coronary arteries. METHODS: Protons in D2 O were hyperpolarized by dissolution dynamic nuclear polarization. A total of 18 mL of hyperpolarized water was injected into the coronary arteries of healthy pigs (N = 9; 3 injections in 3 animals)...
January 12, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29324754/fast-quantitative-murine-cardiac-19f-mri-mrs-of-pfce-labeled-progenitor-stem-cells-and-macrophages-at-9-4t
#4
Christakis Constantinides, Mahon Maguire, Eileen McNeill, Ricardo Carnicer, Edyta Swider, Mangala Srinivas, Carolyn A Carr, Jurgen E Schneider
PURPOSE: To a) achieve cardiac 19F-Magnetic Resonance Imaging (MRI) of perfluoro-crown-ether (PFCE) labeled cardiac progenitor stem cells (CPCs) and bone-derived bone marrow macrophages, b) determine label concentration and cellular load limits, and c) achieve spectroscopic and image-based quantification. METHODS: Theoretical simulations and experimental comparisons of spoiled-gradient echo (SPGR), rapid acquisition with relaxation enhancement (RARE), and steady state at free precession (SSFP) pulse sequences, and phantom validations, were conducted using 19F MRI/Magnetic Resonance Spectroscopy (MRS) at 9...
2018: PloS One
https://www.readbyqxmd.com/read/29312878/case-based-approach-to-demonstrate-utility-of-cardiac-magnetic-resonance-imaging-mri-for-planning-biventricular-repair-with-inconclusive-echo-illustration-of-two-cases
#5
Supriya Gupta, Hanzhou Li, Jayanth H Keshavamurthy, Gyanendra K Sharma, Anastasios C Polimenakos
No abstract text is available yet for this article.
December 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29305613/optimized-time-resolved-echo-piv-ptv-measurements-elucidate-blood-flow-in-patients-with-left-ventricular-thrombus
#6
Kaushik Sampath, Thura T Harfi, Ricard/T George, Joseph Katz
Contrast ultrasound is a widely used clinical tool to obtain real-time qualitative blood flow assessments in the heart, liver, etc. Echocardiographic particle image velocimetry (echo-PIV) is a technique for obtaining quantitative velocity maps from contrast ultrasound images. However, unlike optical PIV, routine echo images are prone to non-uniform spatiotemporal variations in tracer distribution, making analysis difficult for standard PIV algorithms. This study introduces optimized procedures that integrate image enhancement, PIV and particle tracking velocimetry (PTV) to obtain reliable time-resolved 2D velocity distributions...
January 5, 2018: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29298692/an-in-vivo-comparison-of-stimulated-echo-and-motion-compensated-spin-echo-sequences-for-3%C3%A2-t-diffusion-tensor-cardiovascular-magnetic-resonance-at-multiple-cardiac-phases
#7
Andrew D Scott, Sonia Nielles-Vallespin, Pedro F Ferreira, Zohya Khalique, Peter D Gatehouse, Philip Kilner, Dudley J Pennell, David N Firmin
BACKGROUND: Stimulated-echo (STEAM) and, more recently, motion-compensated spin-echo (M2-SE) techniques have been used for in-vivo diffusion tensor cardiovascular magnetic resonance (DT-CMR) assessment of cardiac microstructure. The two techniques differ in the length scales of diffusion interrogated, their signal-to-noise ratio efficiency and sensitivity to both motion and strain. Previous comparisons of the techniques have used high performance gradients at 1.5 T in a single cardiac phase...
January 3, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29296059/clinical-features-management-and-outcome-of-patients-with-constrictive-pericarditis-experience-from-a-third-world-country
#8
Fateh Ali Tipoo Sultan, Muhammad Umer Tariq
Objectives: To study the clinical features, management and outcome of patients with constrictive pericarditis, at a tertiary care hospital of Pakistan. Design: Descriptive study. Material & method: All consecutive patients with the final diagnosis of constrictive pericarditis, admitted at Aga Khan University Hospital Karachi, during the year 2005 to 2015 were included in the study. Results: A total of 21 patients were diagnosed and managed as constrictive pericarditis during the above mentioned period...
January 2018: Journal of the Saudi Heart Association
https://www.readbyqxmd.com/read/29284494/ferumoxytol-enhanced-black-blood-cardiovascular-magnetic-resonance-imaging
#9
Kim-Lien Nguyen, Eun-Ah Park, Takegawa Yoshida, Peng Hu, J Paul Finn
BACKGROUND: Bright-blood and black-blood cardiovascular magnetic resonance (CMR) techniques are frequently employed together during a clinical exam because of their complementary features. While valuable, existing black-blood CMR approaches are flow dependent and prone to failure. We aim to assess the effectiveness and reliability of ferumoxytol enhanced (FE) Half-Fourier Single-shot Turbo Spin-echo (HASTE) imaging without magnetization preparation pulses to yield uniform intra-luminal blood signal suppression by comparing FE-HASTE with pre-ferumoxytol HASTE imaging...
December 28, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29276628/effect-of-slice-excitation-profile-on-ungated-steady-state-cardiac-perfusion-imaging
#10
Haonan Wang, Edward V R DiBella, Ganesh Adluru, Daniel J Park, Meredith I Taylor, Neal K Bangerter
In cardiac perfusion imaging, choice of flip angle is an important factor for steady state acquisition. This work focuses on presenting an analytical framework for understanding how non-ideal slice excitation profiles affect contrast in ungated 2D steady state cardiac perfusion studies, and to study a technique for estimating flip angle that maximizes enhanced/unenhanced myocardial contrast-to-noise ratio (CNR) in single slice and multi-slice acquisitions. A numerical simulation of ungated 2D golden ratio radial spoiled gradient echo (SPGR) was created that takes into consideration the actual (Bloch simulated) slice excitation profile...
April 2017: Biomedical Physics & Engineering Express
https://www.readbyqxmd.com/read/29261532/t2-mapping-for-noninvasive-assessment-of-interstitial-edema-in-acute-cardiac-allograft-rejection-in-a-mouse-model-of-heterotopic-heart-transplantation
#11
Dagmar Hartung, Katja Hueper, Rongjun Chen, Marcel Gutberlet, Frank Wacker, Martin Meier, Song Rong, Mi-Sun Jang, Jan H Bräsen, Faikah Gueler
OBJECTIVES: Heart transplantation (HTX) in mice is used to characterize gene-deficient mice and to test new treatment strategies. The purpose was to establish noninvasive magnetic resonance imaging techniques in mice to monitor pathophysiological changes of the allograft during rejection. MATERIALS AND METHODS: Magnetic resonance imaging was performed at baseline and days 1 and 6 after isogenic (n = 10, C57BL/6) and allogenic (n = 12, C57BL/6 to BALB/c) heterotopic HTX on a 7 T small animal scanner...
December 19, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/29260346/assessment-of-mitral-regurgitation-by-3-dimensional-proximal-flow-convergence-using-magnetic-resonance-imaging-comparison-with-echo-doppler
#12
Lior Gorodisky, Yoram Agmon, Moshe Porat, Sobhi Abadi, Jonathan Lessick
To test the feasibility of assessing mitral regurgitation (MR) severity using cardiac magnetic resonance (CMR) 4D velocity vectors to quantify regurgitant volume (RVol) by analysis of the proximal flow convergence, compared to Doppler based proximal isovelocity surface area (PISA) and CMR volume-based methods. In a prospectively designed study, 27 patients with various grades of MR underwent CMR and echo-Doppler on the same day. By CMR, multiple slices were obtained parallel to the mitral valve by phase-contrast imaging, using 3D velocity vectors, as well as short-axis cine images for left and right ventricular volume measurements...
December 19, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29249433/does-presence-of-left-ventricular-contractile-reserve-improve-response-to-cardiac-resynchronization-therapy-an-updated-meta-analysis
#13
Nikolaos Papageorgiou, Rui Providência, Pier D Lambiase, Dimitris Tousoulis, Guy Lloyd, Sanjeev Bhattacharyya
BACKGROUND: Up to a third of patients undergoing cardiac resynchronization therapy (CRT) do not have a clinical or echocardiographic response. It is also unclear, whether contractile reserve (CR) could predict CRT response. This meta-analysis examines whether the presence of CR improves response to CRT and whether this is modulated by other clinical factors. METHODS: Search of PubMed/EMBASE/Cochrane databases for articles examining response to CRT stratified by the presence or not of CR...
February 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29243396/bariatric-surgery-induced-cardiac-and-lipidomic-changes-in-obesity-related-heart-failure-with-preserved-ejection-fraction
#14
Deana Mikhalkova, Sujata R Holman, Hui Jiang, Mohammed Saghir, Eric Novak, Andrew R Coggan, Robert O'Connor, Adil Bashir, Ali Jamal, Daniel S Ory, Jean E Schaffer, J Christopher Eagon, Linda R Peterson
OBJECTIVE: To determine the effects of gastric bypass on myocardial lipid deposition and function and the plasma lipidome in women with obesity and heart failure with preserved ejection fraction (HFpEF). METHODS: A primary cohort (N = 12) with HFpEF and obesity underwent echocardiography and magnetic resonance spectroscopy both before and 3 months and 6 months after bariatric surgery. Plasma lipidomic analysis was performed before surgery and 3 months after surgery in the primary cohort and were confirmed in a validation cohort (N = 22)...
December 15, 2017: Obesity
https://www.readbyqxmd.com/read/29239839/the-formin-diaph1-is-a-key-modulator-of-myocardial-ischemia-reperfusion-injury
#15
Karen M O'Shea, Radha Ananthakrishnan, Qing Li, Nosirudeen Quadri, Devi Thiagarajan, Gopalkrishna Sreejit, Lingjie Wang, Hylde Zirpoli, Juan Francisco Aranda, Arthur S Alberts, Ann Marie Schmidt, Ravichandran Ramasamy
The biochemical, ionic, and signaling changes that occur within cardiomyocytes subjected to ischemia are exacerbated by reperfusion; however, the precise mechanisms mediating myocardial ischemia/reperfusion (I/R) injury have not been fully elucidated. The receptor for advanced glycation end-products (RAGE) regulates the cellular response to cardiac tissue damage in I/R, an effect potentially mediated by the binding of the RAGE cytoplasmic domain to the diaphanous-related formin, DIAPH1. The aim of this study was to investigate the role of DIAPH1 in the physiological response to experimental myocardial I/R in mice...
November 21, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29232194/persistent-ventricular-bigeminy-during-anesthesia-in-pediatric-patients-a-case-report-of-an-11-year-old-child
#16
Sheetal Dalal, Vikas Chaudhari
An 11-year-old male child with fractures in both bones in his left forearm presented for open reduction and internal fixation. The pre-anesthetic check-up and investigations did not reveal any pre-existing underlying cardio-respiratory disease. The patient had an uneventful peri-operative period during the operation and was comfortable without any anxiety or restlessness. After an uneventful induction and intubation as per routine protocol, the patient received 600 mg of amoxicillin+clavunate intravenously as an antibiotic...
December 12, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29232024/myocardial-perfusion-reserve-index-in-children-with-kawasaki-disease
#17
Richard M Friesen, Michal Schäfer, Pei-Ni Jone, Nana Appiawiah, Daniel Vargas, Brian Fonseca, Michael V DiMaria, Uyen Truong, LaDonna Malone, Lorna P Browne
BACKGROUND: Coronary artery lesions in patients with Kawasaki disease (KD) can impair myocardial perfusion, yet evaluation of perfusion defects by cardiac magnetic resonance (MR) in children is often qualitative. PURPOSE: In this study we aimed to use a quantitative method of myocardial perfusion using stress cardiac MR-derived myocardial perfusion reserve index (MPRI) in children with KD and compare MPRI with ventricular mechanical performance evaluated by cardiac MR strain analysis...
December 12, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29229493/intervendor-consistency-and-accuracy-of-left-ventricular-volume-measurements-using-three-dimensional-echocardiography
#18
Denisa Muraru, Antonella Cecchetto, Umberto Cucchini, Xiao Zhou, Roberto M Lang, Gabriella Romeo, Mani Vannan, Sorina Mihaila, Marcelo Haertel Miglioranza, Sabino Iliceto, Luigi P Badano
BACKGROUND: Intervendor consistency of left ventricular (LV) volume measurements using three-dimensional transthoracic echocardiography (3DTTE) has never been reported. Accordingly, we designed a prospective study to (1) compare head-to-head the accuracy of three three-dimensional echocardiography (3DE) systems in measuring LV volumes and ejection fraction (EF) against cardiac magnetic resonance (CMR); (2) assess the intervendor variability of LV volumes and EF; and (3) compare the accuracy of fully automated versus semiautomated (i...
December 8, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29226689/simultaneous-multi-slice-resting-state-fmri-at-3-tesla-slice-acceleration-related-biases-in-physiological-effects
#19
Ali M Golestani, Zahra Faraji-Dana, M Aras Kayvanrad, Kawin Setsompop, Simon Graham, J Jean Chen
Simultaneous multi-slice echo-planar imaging (EPI) can enhance the spatiotemporal resolution of resting-state functional MRI (rs-fMRI) by encoding and simultaneously imaging "groups" of slices. However, phenomena including respiration, cardiac pulsatility, respiration volume per time (RVT) and cardiac-rate variation (CRV), referred to as "physiological processes", impact SMS-EPI rs-fMRI in a manner that has yet to be well characterized. In particular, physiological noise may incur aliasing and introduce spurious signals from one slice into another within the "slice-group" in rs-fMRI data, resulting in a deleterious effect on resting-state functional connectivity MRI (rs-fcMRI) maps...
December 10, 2017: Brain Connectivity
https://www.readbyqxmd.com/read/29225726/incidence-diagnosis-and-treatment-of-cardiac-toxicity-from-trastuzumab-in-patients-with-breast-cancer
#20
Somaira Nowsheen, Paul V Viscuse, Ciara C O'Sullivan, Nicole P Sandhu, Tufia C Haddad, Anne Blaes, Jennifer Klemp, Lara Nhola, Joerg Herrmann, Kathryn J Ruddy
Purpose of review: Treatment with trastuzumab is a cornerstone of human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancer treatment, but carries an unfortunate risk of toxicity to the cardiovascular system. Here we review recent findings on trastuzumab-associated cardiotoxicity, focusing on its incidence, diagnosis, and treatment. Recent findings: Screening with multigated acquisition scan (MUGA) or echocardiogram (ECHO) is recommended to assess cardiac function prior to and during trastuzumab therapy...
September 2017: Current Breast Cancer Reports
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