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https://www.readbyqxmd.com/read/29774177/the-new-direct-antiviral-agents-and-hepatitis-c-in-thoracic-transplantation-impact-on-donors-and-recipients
#1
REVIEW
Robert L Gottlieb, Shelley A Hall
Purpose of Review: The landscape of abdominal organ transplantation has been altered by the emergence of curative direct-acting antiviral agents for hepatitis C. Expansion of the thoracic donor pool to include the hearts and the lungs from hepatitis C-positive donors holds promise to increase available donor organs. Recent Findings: Case reports have documented separate lung and heart transplant patients who acquired, and then were cured of, donor-derived hepatitis C using these newer, more effective therapies...
2018: Current Transplantation Reports
https://www.readbyqxmd.com/read/29771330/use-of-alternative-agents-for-prevention-of-opportunistic-infections-in-heart-and-lung-transplant-recipients
#2
David J Epstein, Esther Benamu, Aruna Subramanian
No abstract text is available yet for this article.
May 16, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29757444/physical-activity-sedentary-time-and-associated-factors-in-recipients-of-solid-organ-transplantation
#3
Edwin J van Adrichem, Rienk Dekker, Wim P Krijnen, Erik A M Verschuuren, Pieter U Dijkstra, Cees P van der Schans
Background: Short-term survival after solid-organ transplantation has substantially improved, and the focus has shifted to long-term survival, including the role of physical activity (PA). Knowledge about PA and sedentary time in recipients of solid-organ transplantation is limited, and identification of the levels and associated factors is necessary for intervention development. Objective: The objectives of this study were to investigate the level of PA and sedentary time in recipients of solid-organ transplantation and to identify factors associated with these behaviors...
May 10, 2018: Physical Therapy
https://www.readbyqxmd.com/read/29750131/tissue-engineering-toward-organ-specific-regeneration-and-disease-modeling
#4
Christian Mandrycky, Kiet Phong, Ying Zheng
Tissue engineering has been recognized as a translational approach to replace damaged tissue or whole organs. Engineering tissue, however, faces an outstanding knowledge gap in the challenge to fully recapitulate complex organ-specific features. Major components, such as cells, matrix, and architecture, must each be carefully controlled to engineer tissue-specific structure and function that mimics what is found in vivo. Here we review different methods to engineer tissue, and discuss critical challenges in recapitulating the unique features and functional units in four major organs-the kidney, liver, heart, and lung, which are also the top four candidates for organ transplantation in the USA...
September 2017: MRS Communications
https://www.readbyqxmd.com/read/29748530/bk-virus-a-cause-for-concern-in-thoracic-transplantation
#5
Markus J Barten, Andreas Zuckermann
Human BK polyomavirus (BKV) infection is poorly documented in heart and lung transplant patients. BK viruria and viremia have been estimated to affect 19% and 5% of heart transplant recipients, respectively. Data are limited, especially for lung transplantation, but the proportion of patients progressing from BK viruria to viremia or BKV-related nephropathy (BKVN) appears lower than in kidney transplantation. Nevertheless, a number of cases of BKVN have been reported in heart and lung transplant patients, typically with late diagnosis and generally poor outcomes...
May 11, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29744988/behavioral-health-care-in-solid-organ-transplantation-in-a-pediatric-setting
#6
Katharine Thomson, Kristine McKenna, Katherine Bedard-Thomas, Melisa Oliva, Patricia Ibeziako
This study examined the demographic, medical, and psychiatric characteristics of transplant patients across organ groups seen by transplant psychology/psychiatry clinicians at a pediatric institution between 2008 and 2014. Chart reviews were conducted to better understand the behavioral health care provided to SOT patients and the role of transplant-dedicated psychology and psychiatry clinicians. Transplant psychology/psychiatry was consulted a total of 1060 times on 399 unique SOT patients over a 6-year period...
May 10, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29744218/machine-perfusion-of-thoracic-organs
#7
REVIEW
Dirk Van Raemdonck, Filip Rega, Steffen Rex, Arne Neyrinck
This article summarizes recent knowledge and clinical advances in machine perfusion (MP) of thoracic organs. MP of thoracic organs has gained much attention during the last decade. Clinical studies are investigating the role of MP to preserve, resuscitate, and assess heart and lungs prior to transplantation. Currently, MP of the cardiac allograft is essential in all type DCD heart transplantation while MP of the pulmonary allograft is mandatory in uncontrolled DCD lung transplantation. MP of thoracic organs also offers an exciting platform to further investigate downregulation of the innate and adaptive immunity prior to reperfusion of the allograft in recipients...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29740976/high-prevalence-of-diabetes-before-and-after-lung-transplantation-target-for-improving-outcome
#8
Monika Fazekas-Lavu, Michael Reyes, Monique Malouf, Marshall Plit, Adrian Havryk, Lesley V Campbell, Jacqueline R Center, Allan R Glanville, Jerry R Greenfield
BACKGROUND: Diabetes increases morbidity and mortality of lung transplantation. However, the reported prevalence of diabetes varies post-transplantation partly due to lack of detection protocols. AIMS: We determined the prevalence of diabetes in patients (i) waitlisted for lung transplant and (ii) early post-transplantation. METHODS: We analyzed patients on the St Vincent's Heart Lung database from 1/4/14 to 30/9/15 on the waitlist (Study 1) and those transplanted (Study 2)...
May 9, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29737459/safety-of-intra-articular-transplantation-of-lentivirally-transduced-mesenchymal-stromal-cells-for-haemophilic-arthropathy-in-a-non-human-primate
#9
Tsukasa Ohmori, Hiroaki Mizukami, Yuko Katakai, Sho Kawai, Hitoyasu Nakamura, Makoto Inoue, Tsugumine Shu, Hideharu Sugimoto, Yoichi Sakata
Joint bleeding and resultant arthropathy are major determinants of quality of life in haemophilia patients. We previously developed a mesenchymal stromal cell (MSC)-based treatment approach for haemophilic arthropathy in a mouse model of haemophilia A. Here, we evaluated the long-term safety of intra-articular injection of lentivirally transduced autologous MSCs in non-human primates. Autologous bone-marrow-derived MSCs transduced with a lentiviral vector expressing coagulation factor VIII (FVIII) were injected into the left knee joint of cynomolgus monkeys...
May 8, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29734152/cell-sheet-engineering-and-kidney-diseases
#10
Masatoshi Oka, Yoei Miyabe, Naoko Sugiura, Kosaku Nitta
Treatment using the cell sheet technology has been applied to various organs, including the cornea, heart, esophagus, periodontium, cartilage, middle ear, and lungs. It has been shown that the therapeutic efficacy of cell sheet transplantation involves 2 aspects, supplementation of cells and provision of cytokines to the affected organ. In addition, cell sheet transplantation also promotes repair of damage through the paracrine effects of cytokines derived from the transplanted cells. It is known that in cases of cell transplantation by injection, the transplanted cells are less likely to differentiate into renal tissue to supply cells, but repair is promoted by the actions of the transplanted cell-derived renotropic factors...
2018: Contributions to Nephrology
https://www.readbyqxmd.com/read/29723399/outcomes-of-microvascular-flap-reconstruction-of-the-head-and-neck-in-patients-receiving-systemic-immunosuppressive-therapy-for-organ-transplantation
#11
Mark V Schaverien, Riley A Dean, Jeffrey N Myers, Lin Fang, Rene D Largo, Peirong Yu
BACKGROUND: For organ transplant recipients, cancer secondary to immunosuppressive therapy threatens long-term survival. The associated multiple comorbidities make major free flap reconstruction following cancer surgery a complicated event. This study evaluates the outcomes of free flap reconstruction in this population. METHODS: A retrospective chart review of all head and neck free flap cases in patients with a history of organ transplantation receiving systemic immunosuppressive therapy between 2005 and 2017 at a single-institution was conducted...
May 3, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29718077/the-role-of-neuropsychology-on-organ-transplant-teams
#12
Deborah D Roman
Neuropsychological evaluations have been a required component of heart transplant workups at the University of Minnesota Medical Center since 1989. Since end stage kidney, liver, pancreas, and lung disease commonly effects cognition, our service now regularly consults on those transplant teams as well. This article details the role of neuropsychology in a large transplant center, outlining the requisite training and skills needed to serve these patient populations. While transplant is restricted to major medical centers, patients with end stage organ failure are plentiful and can benefit from neuropsychological expertise, providing a substantial source of clinical expansion and research study for our profession...
May 1, 2018: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29710288/the-drug-overdose-epidemic-and-deceased-donor-transplantation-in-the-united-states-a-national-registry-study
#13
Christine M Durand, Mary G Bowring, Alvin G Thomas, Lauren M Kucirka, Allan B Massie, Andrew Cameron, Niraj M Desai, Mark Sulkowski, Dorry L Segev
Background: The epidemic of drug overdose deaths in the United States has led to an increase in organ donors. Objective: To characterize donors who died of overdose and to analyze outcomes among transplant recipients. Design: Prospective observational cohort study. Setting: Scientific Registry of Transplant Recipients, 1 January 2000 to 1 September 2017. Participants: 138 565 deceased donors; 337 934 transplant recipients at 297 transplant centers...
April 17, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29709440/the-2018-ishlt-apm-ast-iccac-stsw-recommendations-for-the-psychosocial-evaluation-of-adult-cardiothoracic-transplant-candidates-and-candidates-for-long-term-mechanical-circulatory-support
#14
EDITORIAL
Mary Amanda Dew, Andrea F DiMartini, Fabienne Dobbels, Kathleen L Grady, Sheila G Jowsey-Gregoire, Annemarie Kaan, Kay Kendall, Quincy-Robyn Young, Susan E Abbey, Zeeshan Butt, Catherine C Crone, Sabina De Geest, Christina T Doligalski, Christiane Kugler, Laurie McDonald, Linda Ohler, Liz Painter, Michael G Petty, Desiree Robson, Thomas Schlöglhofer, Terry D Schneekloth, Jonathan P Singer, Patrick J Smith, Heike Spaderna, Jeffrey J Teuteberg, Roger D Yusen, Paula C Zimbrean
The psychosocial evaluation is well-recognized as an important component of the multifaceted assessment process to determine candidacy for heart transplantation, lung transplantation, and long-term mechanical circulatory support (MCS). However, there is no consensus-based set of recommendations for either the full range of psychosocial domains to be assessed during the evaluation, or the set of processes and procedures to be used to conduct the evaluation, report its findings, and monitor patients' receipt of and response to interventions for any problems identified...
April 27, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29707826/pulmonary-hypertension-is-not-a-risk-factor-for-grade-3-primary-graft-dysfunction-after-lung-transplantation
#15
Silvia R Cottini, Giovanna Brandi, Alberto Pagnamenta, Walter Weder, Reto A Schuepbach, Markus Béchir, Lars C Huber, Christian Benden
Grade 3 primary graft dysfunction (PGD3) represents the most important risk factor for patient mortality during the first year after lung transplantation (LTX). We investigated whether pretransplant pulmonary hypertension (PH) is a risk factor for the development of PGD3. This retrospective, single-center cohort study included 96 candidates undergoing right heart catheterization (RHC) prior to being listed for LTX between March 2000 and October 2015. Based on their mean pulmonary artery pressure (mPAP) levels, the patients were classified into 3 groups: (1) <25 mm Hg, (2) 25-34 mm Hg and (3) ≥35 mm Hg...
April 6, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29707355/pneumatosis-intestinalis-in-solid-organ-transplant-recipients
#16
REVIEW
Vincent Gemma, Daniel Mistrot, David Row, Ronald A Gagliano, Ross M Bremner, Rajat Walia, Atul C Mehta, Tanmay S Panchabhai
Pneumatosis intestinalis (PI) is an uncommon medical condition in which gas pockets form in the walls of the gastrointestinal tract. The mechanism by which this occurs is poorly understood; however, it is often seen as a sign of serious bowel ischemia, which is a surgical emergency. Since the early days of solid organ transplantation, PI has been described in recipients of kidney, liver, heart, and lung transplant. Despite the dangerous connotations often associated with PI, case reports dating as far back as the 1970s show that PI can be benign in solid organ transplant recipients...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29707309/prognostic-value-of-pre-transplant-mean-pulmonary-arterial-pressure-in-lung-transplant-recipients-a-single-institution-experience
#17
Chi Young Kim, Ji Eun Park, Ah Young Leem, Joo Han Song, Song Yee Kim, Kyung Soo Chung, Eun Young Kim, Ji Ye Jung, Young Ae Kang, Young Sam Kim, Joon Chang, Jin Gu Lee, Hyo Chae Paik, Moo Suk Park
Background: Currently, lung transplantation (LTX) is considered to be a curative treatment option in patients with end-stage lung disease. Although pulmonary hypertension (PH), confirmed by cardiac catheterization, is a prognostic factor in patients undergoing LTX, the prognostic value of PH in Asian lung transplant recipients remains uncertain. In this study, we aimed to determine whether PH before LTX may serve as a prognostic factor for survival in Asian patients. Methods: The medical records of 50 patients [male, 27; female, 23; mean age, 51...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29699850/donor-predicted-heart-mass-as-predictor-of-primary-graft-dysfunction
#18
Timothy A Gong, Susan M Joseph, Brian Lima, Gonzalo V Gonzalez-Stawinski, Aayla K Jamil, Joost Felius, Huanying Qin, Giovanna Saracino, Aldo E Rafael, Parag Kale, Shelley A Hall
BACKGROUND: Concern over the hazards associated with undersized donor hearts has impeded the utilization of otherwise viable allografts for transplantation. Previous studies have indicated predicted heart mass (PHM) may provide better size matching in cardiac transplantation than total body weight (TBW). We investigated whether size-matching donor hearts by PHM is a better predictor of primary graft dysfunction (PGD) than matching by TBW. METHODS: Records of consecutive adult cardiac transplants performed between 2012 and 2016 at a single-center academic hospital were reviewed...
March 17, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29686581/a-baylor-milestone-combined-heart-lung-heart-domino-transplant
#19
Peter A Alivizatos
No abstract text is available yet for this article.
January 2018: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/29683220/medical-crowdfunding-for-organ-transplantation
#20
Wesley M Durand, Jillian L Peters, Adam E M Eltorai, Saisanjana Kalagara, Adena J Osband, Alan H Daniels
An increasing number of patients and families are utilizing online crowdfunding to support their medical expenses related to organ transplantation. The factors influencing the success of crowdfunding campaigns are poorly understood. Crowdfunding campaigns were abstracted from a popular crowdfunding website. Campaigns were included if they were actively accepting donations to fund medical expenses related to transplantation of selected organs. The primary outcome measure was total amount raised among successful campaigns receiving at least one donation...
April 23, 2018: Clinical Transplantation
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