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https://www.readbyqxmd.com/read/28106938/vascular-endothelial-growth-factor-targeted-paclitaxel-loaded-liposome-microbubbles-and-inhibition-of-human-epidermoid-2-cell-proliferation
#1
Lian Zhou, Wenlong Luo
BACKGROUND: Vascular endothelial growth factor (VEGF) plays an important role in the formation of capillary blood vessels. The purpose of this study was to evaluate the inhibitory effect of VEGF-targeted paclitaxel (PTX)-loaded liposome microbubbles (VTPLLMs) on the proliferation of human epidermoid (Hep-2) laryngeal squamous cell carcinoma (SCC). METHODS: Six groups were randomly divided. The inhibitory effects on Hep-2 proliferation were assessed by a methylthiazol tetrazolium (MTT) method...
January 20, 2017: Head & Neck
https://www.readbyqxmd.com/read/28102955/compound-speckle-model-detects-anti-angiogenic-tumor-response-in-preclinical-nonlinear-contrast-enhanced-ultrasonography
#2
Matthew R Lowerison, Justin J Tse, M Nicole Hague, Ann F Chambers, David W Holdsworth, James C Lacefield
PURPOSE: This paper proposes a method for analyzing the first-order speckle statistics of nonlinear contrast-enhanced ultrasound images from tumors. METHODS: Contrast signal intensity is modeled as a compound distribution of exponential probability density functions with a gamma weighting function. The gamma probability weighting function serves as an approximation for log-normally distributed flow velocities in a vascular network. The model was applied to sub-harmonic bolus-injection images acquired from a mouse breast cancer xenograft model treated with murine version bevacizumab...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28102777/comparison-of-early-vascular-morphological-changes-between-bioresorbable-poly-l-lactic-acid-scaffolds-and-metallic-stents-in-porcine-iliac-arteries
#3
Yasuhito Sekimoto, Hideaki Obara, Kentaro Matsubara, Naoki Fujimura, Hirohisa Harada, Yuko Kitagawa
Bioresorbable scaffolds have the potential to overcome several problems associated with metallic stents. Bioresorbable poly-L-lactic acid (PLLA) scaffold implantation for the treatment of peripheral artery disease has already been reported in animal models and clinical trials; however, no studies comparing PLLA scaffolds and bare metal stents (BMSs) with regard to early vascular morphological changes, identified using intravascular ultrasound (IVUS) analysis, have been reported. In this study, PLLA scaffolds and BMSs were implanted bilaterally in iliac arteries of five miniature pigs...
January 19, 2017: Organogenesis
https://www.readbyqxmd.com/read/28102453/intravascular-ultrasound-versus-digital-subtraction-angiography-direct-comparison-of-intraluminal-diameter-measurements-in-pediatric-and-adolescent-imaging
#4
Anne E Gill, Tadi Ciszak, Hayley Braun, C Matthew Hawkins
BACKGROUND: Intravascular ultrasound (IVUS) allows intraluminal imaging of blood vessels rather than the one-dimensional luminal outline depicted by digital subtraction angiography (DSA). Despite extensive literature in multiple adult vascular diseases, IVUS has not been directly compared to DSA in pediatric and adolescent vascular pathologies. OBJECTIVE: The purpose of this manuscript is to compare absolute luminal diameter measurements obtained via IVUS and DSA during a variety of pediatric endovascular procedures...
January 19, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28097523/intravascular-ultrasound-characterization-of-a-tissue-engineered-vascular-graft-in-an-ovine-model
#5
Victoria K Pepper, Elizabeth S Clark, Cameron A Best, Ekene A Onwuka, Tadahisa Sugiura, Eric D Heuer, Lilamarie E Moko, Shinka Miyamoto, Hideki Miyachi, Darren P Berman, Sharon L Cheatham, Joanne L Chisolm, Toshiharu Shinoka, Christopher K Breuer, John P Cheatham
Patients who undergo implantation of a tissue-engineered vascular graft (TEVG) for congenital cardiac anomalies are monitored with echocardiography, followed by magnetic resonance imaging or angiography when indicated. While these methods provide data regarding the lumen, minimal information regarding neotissue formation is obtained. Intravascular ultrasound (IVUS) has previously been used in a variety of conditions to evaluate the vessel wall. The purpose of this study was to evaluate the utility of IVUS for evaluation of TEVGs in our ovine model...
January 17, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28092507/real-time-intravascular-ultrasound-and-photoacoustic-imaging
#6
Donald VanderLaan, Andrei B Karpiouk, Doug Yeager, Stanislav Emelianov
Combined intravascular ultrasound and intravascular photoacoustic (IVUS/IVPA) imaging is an emerging hybrid modality being explored as a means of improving the characterization of atherosclerotic plaque anatomical and compositional features. While initial demonstrations of the technique have been encouraging, they have been limited by catheter rotation and data acquisition, displaying, and processing rates on the order of several seconds per frame as well as the use of off-line image processing. Herein, we present a complete IVUS/IVPA imaging system and method capable of real-time IVUS/IVPA imaging, with online data acquisition, image processing, and display of both IVUS and IVPA images...
January 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28090635/sonographic-features-and-diagnosis-of-peripheral-schwannomas
#7
Fan Yang, Xian-Xiang Chen, Huo-Lin Wu, Ji-Fa Zhu, Yuan Chen, Ling-Fang Yu, Xiao-Juan Huang
BACKGROUND: To determine the sonographic features of peripheral schwannomas. METHODS: This retrospective study included 54 cases of schwannoma in 51 patients. Ultrasonography (US) and MRI were performed in all patients. The US features of each tumor were analyzed and compared with pathologic findings. The US target sign was compared with the MRI findings. RESULTS: On US, 53 of the 54 schwannomas had a regular shape and clear margins, and one had an irregular shape...
January 16, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/28076877/ultrasound-imaging-for-ovarian-and-deep-infiltrating-endometriosis
#8
Caterina Exacoustos, Errico Zupi, Emilio Piccione
The main challenges of imaging for endometriosis are the detection of nonovarian disease and the evaluation of the extension of the disease into pelvic structures. Transvaginal ultrasonography (TVS) has been proposed as the first-line imaging technique because it allows extensive exploration of the pelvis. The "typical" endometrioma is a unilocular cyst with homogeneous low-level echogenicity (ground glass echogenicity) of the cyst fluid. The use of color Doppler helps avoid classifying malignancies as endometriomas, defining the presence of vascular flow in papillations...
January 11, 2017: Seminars in Reproductive Medicine
https://www.readbyqxmd.com/read/28074839/high-precision-non-invasive-anti-microvascular-approach-via-concurrent-ultrasound-and-laser-irradiation
#9
Zizhong Hu, Haonan Zhang, Aghapi Mordovanakis, Yannis M Paulus, Qinghuai Liu, Xueding Wang, Xinmai Yang
Antivascular therapy represents a proven strategy to treat angiogenesis. By applying synchronized ultrasound bursts and nanosecond laser irradiation, we developed a novel, selective, non-invasive, localized antivascular method, termed photo-mediated ultrasound therapy (PUT). PUT takes advantage of the high native optical contrast among biological tissues and can treat microvessels without causing collateral damage to the surrounding tissue. In a chicken yolk sac membrane model, under the same ultrasound parameters (1 MHz at 0...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28069611/bioresorbable-vascular-scaffolds-for-the-treatment-of-chronic-total-occlusions-an-international-multicenter-registry
#10
Satoru Mitomo, Toru Naganuma, Yusuke Fujino, Hiroyoshi Kawamoto, Sandeep Basavarajaiah, Michael Pitt, Wei-Hsian Yin, Damras Tresukosol, Antonio Colombo, Sunao Nakamura
BACKGROUND: There are only limited studies reporting clinical outcomes after bioresorbable vascular scaffold (BVS; Absorb; Abbott Vascular, Santa Clara, CA) implantation for coronary chronic total occlusions (CTO). The aim of this study was to evaluate the real-world feasibility and safety of BVS implantation for the treatment of CTO. METHODS AND RESULTS: We retrospectively evaluated CTO cases treated with BVS from a multicenter registry. The primary end point was target lesion failure defined as a composite of cardiac death, target vessel myocardial infarction, and clinically driven target lesion revascularization...
January 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28068731/-geriatric-ultrasound
#11
Eckhart Froehlich, Jan Pauluschke-Froehlich, Ines Debove, Werner Vey, Christoph Klinger, Christoph F Dietrich
In geriatric patients, ultrasound is the appropriate diagnostic technique to detect and to follow-up underlying and accompanying diseases of the heart, lung, liver, kidneys, pancreas, gastrointestinal tract and of arterial and venous vessels. Based on a systematic survey of the published literature, this review describes the value of ultrasound in geriatric patients focussing on point of care.
January 9, 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/28062179/effects-of-non-focused-microbubble-enhanced-and-high-intensity-focused-ultrasound-on-hemostasis-in-a-rabbit-model-of-liver-trauma
#12
Da-Wei Zhao, Meng Tian, Jian-Zhong Zou, Yuan-Yi Zheng, Tao Li
Uncontrolled hemorrhage after trauma to the liver can lead to death. The present study compared the effects of non-focused microbubble-enhanced ultrasound and high-intensity focused ultrasound on hepatic hemostasis in the injured liver. Blood perfusion level, serum liver enzyme levels and the aspartate transaminase/alanine transaminase ratio differed between the two types of treatment (all p values < 0.05). Hepatic cells in the microbubble-enhanced ultrasound group exhibited edema and compressed the hepatic sinus and blood vessels in the portal area...
January 3, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28059849/is-age-an-important-factor-for-vascular-response-to-statin-therapy-a-serial-optical-coherence-tomography-and-intravascular-ultrasound-study
#13
Jiannan Dai, Jingbo Hou, Lei Xing, Haibo Jia, Sining Hu, Tsunenari Soeda, Yoshiyasu Minami, Daniel Ong, Rocco Vergallo, Shaosong Zhang, Hang Lee, Bo Yu, Ik-Kyung Jang
OBJECTIVE: Age-related structural and functional changes in vessel wall may affect the time course of vascular response to statin therapy. In this study, we sought to compare the response of lipid-rich plaque to statin therapy in elderly versus younger patients using optical coherence tomography and intravascular ultrasound. PATIENTS AND METHODS: Sixty-nine patients who underwent serial optical coherence tomography and intravascular ultrasound at the time point of baseline, 6, and 12 months were divided into two groups according to median age: group A (age<57 years, n=35) and group B (age≥57 years, n=34)...
January 4, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28059705/emergent-endovascular-management-of-long-segment-and-flow-limiting-carotid-artery-dissections-in-acute-ischemic-stroke-intervention-with-multiple-tandem-stents
#14
S A Ansari, A L Kühn, A R Honarmand, M Khan, M C Hurley, M B Potts, B S Jahromi, A Shaibani, M J Gounis, A K Wakhloo, A S Puri
BACKGROUND AND PURPOSE: Although most cervical dissections are managed medically, emergent endovascular treatment may become necessary in the presence of intracranial large-vessel occlusions, flow-limiting and long-segment dissections with impending occlusion, and/or hypoperfusion-related ischemia at risk of infarction. We investigated the role of emergent endovascular stenting of long-segment carotid dissections in the acute ischemic stroke setting. MATERIALS AND METHODS: We retrospectively studied long-segment carotid dissections requiring stent reconstruction with multiple tandem stents (≥3 stents) and presenting with acute (<12 hours) ischemic stroke symptoms (NIHSS score, ≥4)...
November 10, 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28056057/flat-anterior-chamber-after-trabeculectomy-in-secondary-angle-closure-glaucoma-with-best1-gene-mutation-case-series
#15
Yimin Zhong, Xinxing Guo, Hui Xiao, Jingyi Luo, Chengguo Zuo, Xiaobo Huang, Jingjing Huang, Lan Mi, Qingjiong Zhang, Xing Liu
PURPOSE: Trabeculectomy has been regarded as a mainstay of initial treatment in eyes of angle closure glaucoma (ACG) with peripheral anterior synechia > 180° in the Chinese population while its efficacy in secondary ACG with BEST1 gene mutation remains unclear. We set out to investigate the treatment outcome of trabeculectomy for secondary ACG in a group of patients with autosomal recessive bestrophinopathy (ARB). METHODS: In this retrospective case series study, 8 secondary ACG patients with ARB and their 4 recruited family members underwent a thorough ophthalmic examination including best-corrected visual acuity, Goldmann applanation tonometry, gonioscopy, and fundus examinations...
2017: PloS One
https://www.readbyqxmd.com/read/28055334/intestinal-malrotation-and-volvulus-in-neonates-laparoscopy-versus-open-laparotomy
#16
Luisa Ferrero, Yosra Ben Ahmed, Paul Philippe, Olivier Reinberg, Isabelle Lacreuse, Anne Schneider, Raphael Moog, Cindy Gomes-Ferreira, François Becmeur
BACKGROUND: Intestinal malrotations with midgut volvulus are surgical emergencies that can lead to life-threatening intestinal necrosis. This study evaluates the feasibility and the outcomes of laparoscopic treatment of midgut volvulus compared with classic open Ladd's procedure in neonates. MATERIALS AND METHODS: The medical records of all neonates with diagnosis of malrotation and volvulus, who underwent surgery between January 1993 and January 2014, were reviewed...
January 5, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28048904/su-g-bra-02-development-of-a-learning-based-block-matching-algorithm-for-ultrasound-tracking-in-radiotherapy
#17
A Shepard, B Bednarz
PURPOSE: To develop an ultrasound learning-based tracking algorithm with the potential to provide real-time motion traces of anatomy-based fiducials that may aid in the effective delivery of external beam radiation. METHODS: The algorithm was developed in Matlab R2015a and consists of two main stages: reference frame selection, and localized block matching. Immediately following frame acquisition, a normalized cross-correlation (NCC) similarity metric is used to determine a reference frame most similar to the current frame from a series of training set images that were acquired during a pretreatment scan...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048296/su-g-jep1-03-automatic-motion-tracking-reset-in-ultrasound-liver-image-sequences
#18
Kele Xu, Ruixing W, Li Zhu, Chang Liu, Yi Zhao
PURPOSE: We explore an automatic anatomical landmarks tracking reset method in the ultrasound liver sequences, with the goal to improve the robustness and accuracy of the tracking. METHODS: The proposed tracking failure re-initialization method works as follows: before anatomic landmarks tracking is carried out, the image similarity coefficient is calculated (In our method, the complex wavelet structural similarity is used), between the region of interest (ROI) selected in current frame and the ROI in the first frame...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28043217/modulation-of-carotid-strain-by-statin-therapy-in-atherosclerosis-patients
#19
Christian Alexander Schaefer, Anna Katharina Blatzheim, Sebastian Gorgonius Passon, Kristin Solveig Pausewang, Nadjib Schahab, Georg Nickenig, Dirk Skowasch, Robert Schueler, Christoph Hammerstingl, Simon Pingel
BACKGROUND: The beneficial effect of statin therapy on the progress of atherosclerotic disease has been demonstrated by numerous studies. Vascular strain imaging is an arising method to evaluate arterial stiffness. Our study examined whether an influence of statin therapy on the vessel wall could be detected by vascular strain imaging. PATIENTS AND METHODS: 88 patients with recently detected atherosclerosis underwent an angiological examination including ankle-brachial index (ABI), pulse wave index (PWI), central puls ewave velocity and duplex ultrasound...
January 3, 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/28042335/targeting-of-magnetic-nanoparticle-coated-microbubbles-to-the-vascular-wall-empowers-site-specific-lentiviral-gene-delivery-in-vivo
#20
Yvonn Heun, Staffan Hildebrand, Alexandra Heidsieck, Bernhard Gleich, Martina Anton, Joachim Pircher, Andrea Ribeiro, Olga Mykhaylyk, Dietmar Eberbeck, Daniela Wenzel, Alexander Pfeifer, Markus Woernle, Florian Krötz, Ulrich Pohl, Hanna Mannell
In the field of vascular gene therapy, targeting systems are promising advancements to improve site-specificity of gene delivery. Here, we studied whether incorporation of magnetic nanoparticles (MNP) with different magnetic properties into ultrasound sensitive microbubbles may represent an efficient way to enable gene targeting in the vascular system after systemic application. Thus, we associated novel silicon oxide-coated magnetic nanoparticle containing microbubbles (SO-Mag MMB) with lentiviral particles carrying therapeutic genes and determined their physico-chemical as well as biological properties compared to MMB coated with polyethylenimine-coated magnetic nanoparticles (PEI-Mag MMB)...
2017: Theranostics
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