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https://www.readbyqxmd.com/read/28095606/endothelin-1-et-1-and-its-receptors-on-haemorrhoidal-tissue-a-potential-site-for-therapeutic-intervention
#1
Varut Lohsiriwat, John H Scholefield, Vincent G Wilson, Michael R Dashwood
BACKGROUND AND PURPOSE: Haemorrhoids is a common anorectal condition affecting millions worldwide. We have studied the effect of endothelin-1 (ET-1) and the role of ETA and ETB receptors in haemorrhoid tissue. EXPERIMENTAL APPROACH: Protein expression of ET-1, ETA and ETB receptors were compared between haemorrhoids and normal rectal submucosa using Western blot analysis, with the localisation of proteins determined by autoradiography and immunohistochemistry. The effect of ET-1 and sarafotoxin 6a on human colonic and rectal arteries and veins was assessed by wire myography and the involvement of receptor subtypes established by selective antagonists...
January 17, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28007520/spinal-anaesthesia-in-outpatient-and-conventional-surgery-a-point-of-view-from-experienced-french-anaesthetists
#2
Régis Fuzier, Christophe Aveline, Paul Zetlaoui, Olivier Choquet, Hervé Bouaziz
INTRODUCTION: The objective of this investigation was to evaluate the practice of spinal anaesthesia among French anaesthetists in inpatient and outpatient settings. METHODS AND MATERIALS: A questionnaire was sent to members of the French Association of Anaesthetists involved in regional anaesthesia during the first 4 months of 2015. The questionnaire included items on the practice of spinal anaesthesia (type of needle, local anaesthetic available, puncture and disinfection techniques, etc...
December 19, 2016: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/27991017/-proctocolectomy-with-j-pouch-ileo-anal-anastomosis-performed-with-pph-stapler-our-experiences-after-88-cases
#3
Csaba Berki, Elemér Mohos, György Réti, Tamás Kovács, Zoltán Jánó, József Mohay, Sándor Horváth, Gábor Bognár, Krisztina Bene, Myroslav Horzov, Gábor Sándor, Gábor Tornai, Petra Mohos, Péter Szenkovits, Tibor Nagy, Csaba Orbán, Vivien Herpai, Attila Nagy
AIM: Ulcerative colitis (CU) or Familiar Polyposis (FAP) can be the indication for proctocolectomy reconstructed with J pouch. The complete removal of the colon mucosa is essential regarding the late complications and at the same time the atraumatic surgical technique is very important concerning on the long term functional results. Both aspects seems to be answered by the stapled ileo-anal anastomosis using a "procedure for prolaps and haemorrhoids (PPH)" stapler applied by us since 2000...
December 2016: Magyar Sebészet
https://www.readbyqxmd.com/read/27974987/a-case-report-of-acute-diverticulitis-in-pseudodiverticulosis-after-hemorpex-system%C3%A2-procedure
#4
Tommaso Testa, Federico Costanzo
Introduction. In the last years many mini-invasive approaches were developed in order to reduce postoperative pain and complication after haemorrhoid surgery: one of these alternatives is represented by Hemorpex System, a relatively young technique that combines transanal dearterialization with mucopexy through a dedicated proctoscope. Case Presentation. A 78-year-old male patient was admitted to the Emergency Department for acute urinary retention and elevated temperature. Hemorpex procedure was performed 4 years before...
2016: Case Reports in Surgery
https://www.readbyqxmd.com/read/27956357/a-survey-of-herbal-weeds-that-are-used-to-treat-gastrointestinal-disorders-from-southern-thailand-krabi-and-songkhla-provinces
#5
Oratai Neamsuvan, Thamakorn Ruangrit
ETHNOPHARMACOLOGICAL RELEVANCE: Weeds are plants grow naturally and are commonly seen. They are mostly used for feedstuff. However, their use as herbs for treating diseases, including gastrointestinal disorders, is rare. Therefore, the present study aimed to: (1) quantify the number of herbal weeds used for treating gastrointestinal disorders; (2) study local knowledge of weed utilization for treating gastrointestinal disorders in Songkhla and Krabi provinces; and (3) analyse quantitative data with the Informant Consensus Factor (ICF), Use Value (UV) and Fidelity Level (FL)...
January 20, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27943513/endoscopic-monopolar-coagulation-of-internal-haemorrhoids-a-surgeon-s-experience-of-the-first-hundred-cases
#6
Wei-Liang Loh, Shaun Tan, Ming Soen Ngooi, Zhongren Konrad Ong, Sing Shang Ngoi
AIM: The purpose of the study was to evaluate one surgeon's initial experience with a novel technique of retroflexed endoscopic coagulation of internal haemorrhoids. METHOD: Patients who presented with symptoms and signs indicating Grade II-III haemorrhoids were counselled before the procedure. Those who were assessed to require an examination of their colon owing to age and other symptoms underwent a full colonoscopy before treatment of the haemorrhoids. After the procedure, patients were routinely prescribed non-steroidal anti-inflammatory drugs, antibiotics and laxatives...
December 10, 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/27936891/comparison-of-different-contouring-definitions-of-the-rectum-as-organ-at-risk-oar-and-dose-volume-parameters-predicting-rectal-inflammation-in-radiotherapy-of-prostate-cancer-which-definition-to-use
#7
Nitsche M, Brannath W, Brückner M, Wagner D, Kaltenborn A, Temme N, Hermann Rm
OBJECTIVES: The objective of this retrospective planning study was to find a contouring definition for the rectum as an organ at risk (OAR) in curative 3D external beam radiotherapy (EBRT) for prostate cancer (PCa) with a predictive correlation between dose-volume-histograms (DVH) and rectal toxicity. METHODS: In a pre-study the planning CT scans of n= 23 patients with PCa receiving definitive EBRT were analysed. The rectum was contoured according to 13 different definitions, and the dose distribution was correlated with the respective rectal volumes by generating DVH curves...
December 12, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27928980/inside-doctor-livingstone-a-scottish-icon-s-encounter-with-tropical-disease
#8
Michael P Barrett, Federica Giordani
Dr David Livingstone died on May 1st 1873. He was 60 years old and had spent much of the previous 30 years walking across large stretches of Southern Africa, exploring the terrain he hoped could provide new environments in which Europeans and Africans could cohabit on equal terms and bring prosperity to a part of the world he saw ravaged by the slave trade. Just days before he died, he wrote in his journal about the permanent stream of blood that he was emitting related to haemorrhoids and the acute intestinal pain that had left him incapable of walking...
December 8, 2016: Parasitology
https://www.readbyqxmd.com/read/27921992/the-hubble-trial-haemorrhoidal-artery-ligation-hal-versus-rubber-band-ligation-rbl-for-symptomatic-second-and-third-degree-haemorrhoids-a-multicentre-randomised-controlled-trial-and-health-economic-evaluation
#9
Steven Brown, Jim Tiernan, Katie Biggs, Daniel Hind, Neil Shephard, Mike Bradburn, Allan Wailoo, Abualbishr Alshreef, Lizzie Swaby, Angus Watson, Simon Radley, Oliver Jones, Paul Skaife, Anil Agarwal, Pasquale Giordano, Marc Lamah, Mark Cartmell, Justin Davies, Omar Faiz, Karen Nugent, Andrew Clarke, Angus MacDonald, Phillip Conaghan, Paul Ziprin, Rohit Makhija
BACKGROUND: Optimal surgical intervention for low-grade haemorrhoids is unknown. Rubber band ligation (RBL) is probably the most common intervention. Haemorrhoidal artery ligation (HAL) is a novel alternative that may be more efficacious. OBJECTIVE: The comparison of HAL with RBL for the treatment of grade II/III haemorrhoids. DESIGN: A multicentre, parallel-group randomised controlled trial. PERSPECTIVE: UK NHS and Personal Social Services...
November 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27845508/may-radiofrequency-be-the-best-choice-for-iii-iv-degree-hemorrhoids-results-of-a-large-series-of-patients
#10
Giovanni Milito, Giorgio Lisi, Elena Aronadio, Michela Campanelli, Dario Venditti, Simona Grande, Michele Grande
BACKGROUND: Haemorrhoidectomy is considered the most efficient method to treat haemorrhoids of III and IV grades. The aim of this study is to compare conventional diathermy haemorrhoidectomy and radiofrequency haemorrhoidectomy based on a large series of patients. METHODS: Between June 2001 and June 2014, 1000 patients have been treated with radiofrequency haemorrhoidectomy (Group A) and 500 patients have been treated with diathermy (Group B) as a day-case procedure...
November 15, 2016: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/27825178/ruscus-genus-a-rich-source-of-bioactive-steroidal-saponins
#11
Milena Masullo, Cosimo Pizza, Sonia Piacente
The genus Ruscus (Asparagaceae family) is native to the Mediterranean, Southern and Western Europe and is represented by perennial, rhizomatous, and evergreen shrubs. Among the approximately seven species spread throughout Europe up to Iran, Ruscus aculeatus L. (butcher's broom) is the most widely distributed and appreciated. This review provides an overview of the traditional use of Ruscus spp., the current knowledge of the chemistry of this genus, and the pharmacological studies carried out on Ruscus spp...
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27813396/stapled-anopexy-versus-transanal-hemorrhoidal-dearterialization-for-hemorrhoidal-disease-a-three-year-follow-up-from-a-randomized-study
#12
Marco Venturi, Giovanni Salamina, Contardo Vergani
BACKGROUND: This randomized study compared the medium-term results of stapled anopexy (SA) and transanal hemorrhoidal dearterialization with anopexy (THD) in 4 homogeneous groups of patients, 2 with third- and 2 with fourth-degree hemorrhoids. METHODS: Forty patients with third-degree and 30 with fourth-degree hemorrhoids were randomly submitted to SA (N.=20+15) and THD (N.=20+15), respectively. Clinical controls were done every 6 months from 1 to 42 months after the operation, with incidence of recurrent hemorrhoids as primary outcome measure...
December 2016: Minerva Chirurgica
https://www.readbyqxmd.com/read/27801539/does-a-more-extensive-mucosal-excision-prevent-haemorrhoidal-recurrence-after-stapled-haemorrhoidopexy-long-term-outcome-of-a-randomised-controlled-trial
#13
Donato F Altomare, Giuseppe Pecorella, Guido Tegon, Fabrizio Aquilino, Damiano Pennisi, Michele De Fazio
AIM: The study aimed in a multicentric randomised controlled trial to define the role of a more extensive mucosal resection on recurrence of mucosal prolapse in patients with stage III haemorrhoids undergoing stapled haemorrhoidopexy . METHOD: 135 patients were randomised to treatment with PPH01/03 or an EEA stapler. They were reviewed after a minimum follow-up of four years to determine the rate of recurrent mucosal prolapse, and general condition (Wellness evaluation score)...
November 1, 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/27790516/small-cell-carcinoma-of-anal-canal-a-rare-case-report
#14
Surag, Chandrashekar Neeralagi, Arun Prasath, Puneeth Kumar, Bharath Reddy
Anal canal malignancy is one of the dreadful conditions. Most of the anal canal malignancies are squamous cell carcinomas for which the treatment is well established and the prognosis is usually favourable. Small cell carcinoma of anal canal is a very rare condition and poorly understood, which can present as haemorrhoids in its early stages and has an aggressive course. We present a case of small cell carcinoma of anal canal who underwent Abdomino Perineal Resection (APR) and chemotherapy. He developed liver metastasis during the course of chemotherapy and succumbed to the condition 4 months later...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27768009/ligasuretm-hemorrhoidectomy-how-we-do
#15
Giovanni Milito, Giorgio Lisi, Elena Aronadio, Michela Campanelli, Dario Venditti, Simona Grande, Michele Grande
BACKGROUNDS: Hemorrhoidectomy is considered the gold standard and the most effective and definitive treatment for grades 3 or 4 haemorrhoids, and Milligan-Morgan's and Ferguson's procedures are the most widely used techniques throughout the world. The aim of the study is to present our surgical technique using LigasureTM vessel sealing, focus on technical aspects and surgical tricks showing our results with a huge number of patients and a long-term follow-up. METHODS: Between June 2001 and June 2014 at the University Hospital of Tor Vergata, Rome, Italy, 1000 patients were selected to underwent LigaSureTM hemorrhoidectomy for III and IV degree haemorrhoids...
October 21, 2016: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/27766395/evidence-based-management-of-pain-after-excisional-haemorrhoidectomy-surgery-a-prospect-review-update
#16
Tarik Sammour, Ahmed W H Barazanchi, Andrew G Hill
BACKGROUND: The aim of this systematic review was to update previous PROSPECT ( http://www.postoppain.org ) review recommendations for the management of pain after excisional haemorrhoidectomy. METHODS: Randomized studies and reviews published in the English language from July 2006 (end date of last review) to March 2016, assessing analgesic, anaesthetic, and operative interventions pertaining to excisional haemorrhoidectomy in adults, and reporting pain scores, were retrieved from the EMBASE and MEDLINE databases...
October 20, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27726951/comparison-of-stapled-haemorrhoidopexy-with-traditional-excisional-surgery-for-haemorrhoidal-disease-ethos-a-pragmatic-multicentre-randomised-controlled-trial
#17
Angus J M Watson, Jemma Hudson, Jessica Wood, Mary Kilonzo, Steven R Brown, Alison McDonald, John Norrie, Hanne Bruhn, Jonathan A Cook
BACKGROUND: Two commonly performed surgical interventions are available for severe (grade II-IV) haemorrhoids; traditional excisional surgery and stapled haemorrhoidopexy. Uncertainty exists as to which is most effective. The eTHoS trial was designed to establish the clinical effectiveness and cost-effectiveness of stapled haemorrhoidopexy compared with traditional excisional surgery. METHODS: The eTHoS trial was a large, open-label, multicentre, parallel-group, pragmatic randomised controlled trial done in adult participants (aged 18 years or older) referred to hospital for surgical treatment for grade II-IV haemorrhoids...
November 12, 2016: Lancet
https://www.readbyqxmd.com/read/27699495/hubble-trial-time-to-stick-to-basics-for-treatment-of-haemorrhoids
#18
S R Brown
The results of the Hubble trial, a randomised controlled trial comparing haemorrhoidal artery ligation with rubber band ligation for early-grade prolapsing haemorrhoids, are discussed. The difficulties in defining treatment success are debated along with the trial design highlighting the pitfalls of previous research. A finding that haemorrhoidal artery ligation is not necessarily superior to cheap alternatives has implications for current practice and future commissioning of surgeons.
October 3, 2016: Techniques in Coloproctology
https://www.readbyqxmd.com/read/27676782/bladder-sphincter-disorders-and-quality-of-life-of-traumatic-brain-injury-tunisian-experience
#19
Mariem Rekik, Khaoula Achour, Anouer Abdallah, Sonia Lebib, Imen Miri, Fatima Zahra Ben Salah, Catherine Dziri
OBJECTIVE: The aim of our study was to assess the bladder and sphincter function after brain injury (BI) and to review their association with quality of life (QOL). MATERIAL/PATIENTS AND METHODS: We conducted a cross-sectional study, including patients referred to physical and rehabilitation medicine department at the Med Kassab Institute of Orthopedics. The initial gravity data were collected. The bladder-sphincter assessment included evaluation of the urine drain mode, the irritative disorders, obstructive disorders, disorders of transit and the existence of secondary anal lesions...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27669689/metamizole-versus-ibuprofen-at-home-after-day-surgery-study-protocol-for-a-randomised-controlled-trial
#20
Björn Stessel, Michiel Boon, Elbert A Joosten, Jean-Paul Ory, Stefan Evers, Sander M J van Kuijk, Jasperina Dubois, Daisy Hoofwijk, Luc Jamaer, Wolfgang F F A Buhre
BACKGROUND: Postoperative pain and, in a more extended perspective, quality of recovery (QOR) should be considered the principal endpoints after day surgery. Non-steroidal anti-inflammatory drugs (NSAIDs) and paracetamol are a cornerstone of pain treatment after painful day surgery. Nevertheless, NSAIDs are not always sufficiently effective, have numerous contraindications, and consequently are not suitable in up to 25 % of all patients. Metamizole is a non-opioid compound with a favourable gastrointestinal, cardiovascular and cerebrovascular profile compared to NSAIDs...
September 26, 2016: Trials
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