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https://www.readbyqxmd.com/read/29888992/advances-in-rectal-drug-delivery-systems
#1
Trusha J Purohit, Sara M Hanning, Zimei Wu
Drug delivery via the rectum is a useful alternative route of administration to the oral route for patients who cannot swallow. Traditional rectal dosage forms have been traditionally used for localised treatments including delivery of laxatives, treatment of haemorrhoids and for delivery of antipyretics. However, the recent trend is showing an increased incline for development of novel rectal delivery systems to deliver drug directly into the systemic circulation by taking advantage of porto-systemic shunting...
June 11, 2018: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/29868154/a-seven-year-retrospective-review-of-colonoscopy-records-from-a-single-centre-in-zambia
#2
Violet Kayamba, Kate Nicholls, Catrin Morgan, Paul Kelly
Introduction: Colorectal disease is common throughout the world, but the spectrum of diagnoses across Africa remains largely unexplored. There is anecdotal evidence of changing colorectal disease but this has not been systematically investigated. The aim of this study was to enhance our insight into the spectrum of colonoscopic diagnoses in Zambia. Methods: We retrieved written colonoscopy reports from January 2008 to December 2015. Collected data were coded by experienced endoscopists and analysed by age, sex, referral source, indication and diagnosis...
March 2018: Malawi Medical Journal: the Journal of Medical Association of Malawi
https://www.readbyqxmd.com/read/29797246/embolization-of-superior-rectal-arteries-for-transfusion-dependent-haemorrhoidal-bleeding-in-severely-cardiopathic-patients-a-new-field-of-application-of-the-emborrhoid-technique
#3
M Venturini, P De Nardi, P Marra, M Panzeri, G Brembilla, F Morelli, F Melchiorre, F De Cobelli, A Del Maschio
No abstract text is available yet for this article.
May 24, 2018: Techniques in Coloproctology
https://www.readbyqxmd.com/read/29776947/rectal-mucocele-in-the-anterior-wall-of-the-rectum
#4
Daisuke Ishii, Takanori Aoki, Satoshi Inaba, Hidehiko Yabuki
An 84-year-old man presented in 2009 with a sensation of discomfort in his anus, combined with difficulty in urination. He had previously undergone a haemorrhoidectomy in 1964. After examination, he was diagnosed with a rectal mucosal cyst and followed up for observation. In 2015, he presented to our hospital complaining that the cyst was prolapsing from his anus. CT revealed a 48×41 mm cystic mass in the anterior wall of the rectum. Tumour extirpation, via a transanal route, was performed. The postoperative pathological diagnosis confirmed a rectal mucocele...
May 18, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29707238/open-surgery-for-haemorrhoids-in-persons-with-spinal-cord-injury
#5
J G Previnaire, N De Bont, H Bordi, N Senal, P E Mortier
Study design: Pilot retrospective study on the outcome of open surgery for grade III and IV haemorrhoids in patients with SCI. Objective: Haemorrhoids and anal fissures are common in patients with spinal cord injury (SCI). Grade I to III haemorrhoids are usually managed medically or by surgical ligation. Grade III and IV haemorrhoids are treated with surgical haemorrhoidectomy in the general population, but not in patients with SCI, most probably due to fear of complications...
2018: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/29623627/cost-effectiveness-of-stapled-haemorrhoidopexy-and-traditional-excisional-surgery-for-the-treatment-of-haemorrhoidal-disease
#6
Mary M Kilonzo, Steven R Brown, Hanne Bruhn, Jonathan A Cook, Jemma Hudson, John Norrie, Angus J M Watson, Jessica Wood
OBJECTIVE: Our objective was to compare the cost effectiveness of stapled haemorrhoidopexy (SH) and traditional haemorrhoidectomy (TH) in the treatment of grade II-IV haemorrhoidal disease from the perspective of the UK national health service. METHODS: An economic evaluation was conducted alongside an open, two-arm, parallel-group, pragmatic, multicentre, randomised controlled trial conducted in several hospitals in the UK. Patients were randomised into either SH or TH surgery between January 2011 and August 2014 and were followed up for 24 months...
August 25, 2017: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29569071/coloproctology-procedure-clinic-a-novel-service-developed-to-reduce-suffering-of-patients-with-bleeding-per-rectum
#7
Yasir Bashir, Bernadette McGovern, Mohammed Tahtouh, Tahir Abbasi, Maria Murphy, Paul Neary
AIMS: Evaluation of the role and impact of introducing a dedicated coloproctology procedure clinic in tertiary referral colorectal unit. METHODS: A retrospective analysis of 126 consecutive patients managed in the coloproctology clinic between March2015 and September 2016 was carried out. All patients were preselected for attendance based on symptom-based protocol. RESULTS: Based on the information available in GP referrals, 126 patients with bleeding per rectum with low risk of cancer were re-triaged from the general outpatient to dedicated coloproctology procedure clinic...
March 22, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29560836/relationship-between-bidet-toilet-use-and-haemorrhoids-and-urogenital-infections-a-3-year-follow-up-web-survey
#8
K Asakura, M Nakano, K Omae
Given the growing use of electric bidet toilets in Japan and other countries, we assessed the relationship between bidet toilet use and haemorrhoids or urogenital infections. Data were collected using a web-based longitudinal survey. In total, 10 305 subjects randomly selected from panels of a Japanese website research company for the baseline survey in 2013 were asked about their frequency of bidet toilet use and receipt of a doctor's diagnosis or subjective symptom of haemorrhoids and urogenital infections...
April 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29489879/cd4-cd25-foxp3-t-cell-frequency-in-the-peripheral-blood-is-a-biomarker-that-distinguishes-intestinal-tuberculosis-from-crohn-s-disease
#9
Veena Tiwari, Saurabh Kedia, Sushil Kumar Garg, Ritika Rampal, V Pratap Mouli, Anuja Purwar, D K Mitra, Prasenjit Das, S Dattagupta, Govind Makharia, S K Acharya, Vineet Ahuja
BACKGROUND: Distinguishing between Crohn's Disease (CD) and Intestinal Tuberculosis (ITB) has been a challenging task for clinicians due to their similar presentation. CD4+FOXP3+ T regulatory cells (Tregs) have been reported to be increased in patients with pulmonary tuberculosis. However, there is no such data available in ITB. The aim of this study was to investigate the differential expression of FOXP3+ T cells in patients with ITB and CD and its utility as a biomarker. METHODS: The study prospectively recruited 124 patients with CD, ITB and controls: ulcerative colitis (UC) and patients with only haemorrhoidal bleed...
2018: PloS One
https://www.readbyqxmd.com/read/29457050/pelvic-catastrophe-after-elastic-band-ligation-in-an-irradiated-rectum
#10
Inês Pita, Pedro Bastos, Mário Dinis-Ribeiro
Chronic radiation proctopathy is a frequent complication after both pelvic external radiation therapy and brachytherapy and most commonly presents as rectal bleeding. Deep rectal ulcers and fistulae are much rarer and more clinically challenging consequences. We present the case of a 72-year-old male with a history of prostate adenocarcinoma treated with brachytherapy, who was referred to our institution due to a deep painful rectal ulcer refractory to medical treatment. The ulcer presented shortly after a haemorrhoid elastic band ligation and progressed to rectourethral fistulisation despite both faecal and urinary diversion...
January 2018: GE Portuguese Journal of Gastroenterology
https://www.readbyqxmd.com/read/29441497/cost-effectiveness-of-haemorrhoidal-artery-ligation-versus-rubber-band-ligation-for-the-treatment-of-grade-ii-iii-haemorrhoids-analysis-using-evidence-from-the-hubble-trial
#11
Abualbishr Alshreef, Allan J Wailoo, Steven R Brown, James P Tiernan, Angus J M Watson, Katie Biggs, Mike Bradburn, Daniel Hind
AIM: Haemorrhoids are a common condition, with nearly 30,000 procedures carried out in England in 2014/15, and result in a significant quality-of-life burden to patients and a financial burden to the healthcare system. This study examined the cost effectiveness of haemorrhoidal artery ligation (HAL) compared with rubber band ligation (RBL) in the treatment of grade II-III haemorrhoids. METHOD: This analyses used data from the HubBLe study, a multicentre, open-label, parallel group, randomised controlled trial conducted in 17 acute UK hospitals between September 2012 and August 2015...
September 2017: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29341181/baboon-syndrome-caused-by-anti-haemorrhoidal-ointment
#12
Eugénia Matos-Pires, David Pina-Trincão, Susana Brás, Lurdes Lobo
No abstract text is available yet for this article.
February 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29306891/community-pharmacists-services-for-women-during-pregnancy-and-breast-feeding-in-kuwait-a-cross-sectional-study
#13
Abdullah Albassam, Abdelmoneim Awad
OBJECTIVES: This study was designed to identify the services provided by community pharmacists in Kuwait and their views regarding self-care in pregnancy and lactation. In addition, it determined the pharmacists' recommendations for treatment of pregnancy-related and breast feeding-related ailments. DESIGN: Cross-sectional questionnaire-based survey. SETTING: Community pharmacies in Kuwait. PARTICIPANTS: 207 pharmacies were randomly selected from the Ministry of Health database...
January 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29214383/evaluation-of-the-effectiveness-and-patients-contentment-with-transanal-haemorrhoidal-artery-dearterialisation-and-mucopexy-thd-for-treatment-of-haemorrhoidal-disease-a-6-year-study
#14
Qurat Ul Ain, Yasir Bashir, Emmanuel Eguare
INTRODUCTION: With high incidence of haemorrhoidal disease and significant complication rates of traditional haemorrhoidectomy procedures, transanal haemorrhoidal artery ligation and mucopexy (THD) emerges as a minimally invasive procedure with superior results. However, it is crucial that effectiveness of results and patient satisfaction be gauged based on post-operative experience, symptomology and recurrence. AIM: Our aim is to provide a long-term analysis of efficacy and patient's satisfaction for the procedure, for the largest patient population, in correlation to presenting symptoms and degree of haemorrhoids...
December 6, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29205150/a-pragmatic-multicentre-randomised-controlled-trial-comparing-stapled-haemorrhoidopexy-with-traditional-excisional-surgery-for-haemorrhoidal-disease-the-ethos-study
#15
Angus Jm Watson, Jonathan Cook, Jemma Hudson, Mary Kilonzo, Jessica Wood, Hanne Bruhn, Steven Brown, Brian Buckley, Finlay Curran, David Jayne, Malcolm Loudon, Ramesh Rajagopal, Alison McDonald, John Norrie
BACKGROUND: Haemorrhoids are a benign anorectal condition and are highly prevalent in the UK population. Treatments involve clinic-based procedures and surgery. The surgical procedures available include stapled haemorrhoidopexy (SH) and traditional haemorrhoidectomy (TH), and over 25,000 operations are performed for haemorrhoids annually in the UK. The disease is therefore important both to patients and to health service commissioners. Debate remains as to which of these surgical procedures is the most clinically effective and cost-effective...
November 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29186745/-laserhemorrhoidoplasty-with-1470-nm-diode-laser-in-the-treatment-of-second-to-fourth-degree-hemorrhoidal-disease-a-cohort-study-with-497-patients
#16
Guido Weyand, Claudia Susanne Theis, Aboubacar Nzambi Fofana, Felix Rüdiger, Thomas Gehrke
Background Laser haemorrhoidoplasty (LHP) with the 1470 nm diode laser in minimally invasive surgery for advanced haemorrhoid disease has been studied with respect to clinical variables, such as pain and complications, and intraoperative characteristics such as mucopexia, number of treated knots and energy consumed per patient. The study also included patient satisfaction, symptom relevance and cost effectiveness. Patients and Methods Between November 2010 and November 2016, 497 patients (age 55 ± 14 years) were submitted to laser haemorrhoidoplasty with a 1470 nm diode laser in the centre for minimally invasive proctology in Siegen District Hospital...
November 29, 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/29110411/incidence-of-new-onset-benign-anal-disorders-after-bariatric-surgery
#17
O Cano-Valderrama, A Sánchez-Pernaute, M A Rubio, P Talavera, E Martín-Antona, A J Torres
New-onset benign anal disorders (NBADs) represent a potential complication following bariatric surgery, although their incidence in this population is not well studied. The preoperative characteristics, weight loss, bowel habits and NBADs data of 196 patients with bariatric surgery were collected by telephone interviews and medical records review and evaluated retrospectively. Ninety-nine patients had undergone gastric bypass (GBP) and 97 had a modified biliopancreatic diversion (MBPD). Fifty-nine patients were excluded...
February 2018: Clinical Obesity
https://www.readbyqxmd.com/read/29079186/investigating-the-association-between-african-spontaneously-fermented-dairy-products-faecal-carriage-of-streptococcus-infantarius-subsp-infantarius-and-colorectal-adenocarcinoma-in-kenya
#18
Dasel W M Kaindi, Wambui Kogi-Makau, Godfrey N Lule, Bernd Kreikemeyer, Pierre Renault, Bassirou Bonfoh, Esther Schelling, Jakob Zinsstag, Christophe Lacroix, Leo Meile, Christoph Jans, Jan Hattendorf
Consumption of traditional fermented dairy products (tFDP) in Africa leads to the ingestion of up to 108 Streptococcus infantarius subspecies infantarius (Sii) per millilitre of spontaneously fermented milk. Sii is a member of the Streptococcus bovis/Streptococcus equinus complex (SBSEC) for which some members are associated particularly with colorectal cancer or endocarditis. The extent of health risks to tFDP consumers is largely unknown. A hospital-based unmatched case-control study was conducted at Kenyatta National Hospital, Nairobi (Kenya) on 80 cases and 193 controls that were selected exhaustively from patients attending colonoscopy at the hospital...
February 2018: Acta Tropica
https://www.readbyqxmd.com/read/29076685/causes-of-lower-gastrointestinal-bleeding-on-colonoscopy
#19
Attique-Ur-Rehman Jehangiri, Rahid Gul, Rania Hadayat, Adil Naseer Khan, Zabiullah, Liaqat Khursheed
BACKGROUND: Bleeding from anus is usually referred as rectal bleeding but actually rectal bleeding is defined as bleeding from lower colon or rectum, which means bleeding from a place distal to ligament of Treitz. This study was conducted to determine the frequency of different causes of rectal bleeding in patients at Ayub Teaching Hospital, Abbottabad. METHODS: One hundred and seventy-five patients with evidence of rectal bleed, without gender discrimination were selected by non-probability convenient sampling from the out-patient department and general medical wards...
July 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29046080/the-use-of-viable-cryopreserved-placental-tissue-in-the-management-of-a-chronic-rectovaginal-fistula
#20
J P Taylor, S Gearhart
We present a case of a chronic recurrent rectovaginal fistula that initially arose from complications of haemorrhoid surgery and had failed multiple prior surgical repairs. The fistula was successfully managed using viable cryopreserved placental tissue.
November 2017: Annals of the Royal College of Surgeons of England
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