Yanan Xu, Qian Zhang, Runzhi Chen, Haiting Cao, Jie Tang, Yuqi Wu, Xing Lu, Binbin Chu, Bin Song, Houyu Wang, Yao He
Herein, we designed and synthesized a novel microRNA (miR)-responsive nanoantenna capable of early diagnosis and smart treatment of acute kidney injury (AKI). The nanoantenna was made of two miniature gold nanorods (AuNRs) ( e.g. , length: ∼48 nm; width: ∼9 nm) linked together by a rectangular DNA origami nanostructure (rDONs) scaffold ( e.g. , length: ∼90 nm; width: ∼60 nm) (rDONs@AuNR dimer). The surface plasmon resonance peak of the constructed nanoantenna is located within the NIR-II window ( e...
December 12, 2022: Journal of the American Chemical Society