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https://www.readbyqxmd.com/read/28735097/protecting-the-heart-through-mk2-modulation-toward-a-role-in-diabetic-cardiomyopathy-and-lipid-metabolism
#1
REVIEW
Matthieu Ruiz, Lise Coderre, Bruce Gordon Allen, Christine Des Rosiers
Various signaling pathways have been identified in the heart as important players during development, physiological adaptation or pathological processes. This includes the MAPK families, particularly p38MAPK, which is involved in several key cellular processes, including differentiation, proliferation, apoptosis, inflammation, metabolism and survival. Disrupted p38MAPK signaling has been associated with several diseases, including cardiovascular diseases (CVD) as well as diabetes and its related complications...
July 19, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28735077/opioid-medication-misuse-among-unhealthy-drinkers
#2
Gerald Cochran, Rebecca McCarthy, Adam J Gordon, Ralph E Tarter
BACKGROUND: Combining opioid medications and alcohol has serious implications for patient health, including overdose. Information regarding those who use/misuse opioid medications and engage in unhealthy alcohol use is limited to pharmacological and epidemiological descriptions. This study presents opioid medication misuse and behavioral, mental, and physical health characteristics of persons filling opioid medications that are engaged in unhealthy alcohol use. METHODS: We conducted a cross-sectional survey at 5 community pharmacies in Southwestern, Pennsylvania among patients filling opioid medications...
July 14, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28734844/tlr3-blockade-in-rhinovirus-induced-experimental-asthma-exacerbations-a-randomized-controlled-study
#3
Philip E Silkoff, Susan Flavin, Robert Gordon, Mathew J Loza, Peter J Sterk, Rene Lutter, Zuzana Diamant, Ronald B Turner, Brian J Lipworth, David Proud, Dave Singh, Andreas Eich, Vibeke Backer, James E Gern, Christian Herzmann, Scott A Halperin, Tjeert T Mensinga, Alfred M Del Vecchio, Patrick Branigan, Lani San Mateo, Frédéric Baribaud, Elliot S Barnathan, Sebastian L Johnston
BACKGROUND: Human rhinoviruses (HRV) commonly precipitate asthma exacerbations. TLR3, an innate pattern-recognition receptor, is triggered by HRV driving inflammation that may worsen asthma. OBJECTIVE: To evaluate an inhibitory monoclonal antibody to TLR3, CNTO3157, on experimental HRV-16 inoculation in healthy and asthmatic subjects. METHODS: In this double-blind multicenter randomized parallel-group study in North America and Europe, healthy and mild-moderate stable asthmatic subjects received single or multiple doses of CNTO 3157 or placebo, respectively, and were then inoculated with HRV-16 within 72 hours...
July 19, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28734783/dementia-prevalence-and-incidence-in-a-federation-of-european-electronic-health-record-databases-the-european-medical-informatics-framework-resource
#4
Gayan Perera, Lars Pedersen, David Ansel, Myriam Alexander, H Michael Arrighi, Paul Avillach, Nadia Foskett, Rosa Gini, Mark F Gordon, Usha Gungabissoon, Miguel-Angel Mayer, Gerald Novak, Peter Rijnbeek, Gianluca Trifirò, Johan van der Lei, Pieter J Visser, Robert Stewart
INTRODUCTION: The European Medical Information Framework consortium has assembled electronic health record (EHR) databases for dementia research. We calculated dementia prevalence and incidence in 25 million persons from 2004 to 2012. METHODS: Six EHR databases (three primary care and three secondary care) from five countries were interrogated. Dementia was ascertained by consensus harmonization of clinical/diagnostic codes. Annual period prevalences and incidences by age and gender were calculated and meta-analyzed...
July 20, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28734561/avoiding-adult-in-hospital-cardiac-arrest-a-retrospective-cohort-study-to-determine-preventability
#5
Gordon Bingham, Irma Bilgrami, Mandy Sandford, Sarah Larwill, Judit Orosz, Carl Luckhoff, Tony Kambourakis
INTRODUCTION: This study had three main aims. Develop a methodology for reviewing in-hospital cardiac arrests (IHCA). Assess appropriateness and potential preventability of IHCAs. Identify areas for improvement within the rapid response system (RRS). DESIGN: A retrospective cohort study of IHCA identified from an existing organisational electronic database of medical emergency (MET) and Code Blue team activation. Potential preventability of IHCA and Code Blue team activation were established by an expert panel based on a standardised case review process with descriptive and content analyses for each IHCA event...
July 19, 2017: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://www.readbyqxmd.com/read/28734118/the-perniciousness-of-perfectionism-a-meta-analytic-review-of-the-perfectionism-suicide-relationship
#6
Martin M Smith, Simon B Sherry, Samantha Chen, Donald H Saklofske, Christopher Mushquash, Gordon L Flett, Paul L Hewitt
Over 50 years of research implicates perfectionism in suicide. Yet the role of perfectionism in suicide needs clarification due to notable between-study inconsistencies in findings, underpowered studies, and uncertainty whether perfectionism confers risk for suicide. OBJECTIVE: We addressed this by meta-analyzing perfectionism's relationship with suicide ideation and attempts. We also tested whether self-oriented, other-oriented, and socially prescribed perfectionism predicted increased suicide ideation, beyond baseline ideation...
July 22, 2017: Journal of Personality
https://www.readbyqxmd.com/read/28733920/complementary-and-alternative-medicine-among-persons-living-with-hiv-in-the-era-of-combined-antiretroviral-treatment
#7
Sean N Halpin, Edwin Clayton Carruth, Ramona P Rai, E Jennifer Edelman, David A Fiellin, Cynthia Gibert, Kirsha S Gordon, Wei Huang, Amy Justice, Vincent C Marconi, David Rimland, Molly M Perkins
Complementary and alternative medicine (CAM), often pursued independent of prescribing clinicians, may interact with traditional treatments, yet CAM use has not been well characterized among people living with HIV (PLWH) in the combined antiretroviral therapy (ART) era. We analyzed data from the Veterans Aging Cohort Study (October 2012-April 2015) to characterize CAM use in PLWH on ART. CAM users were more likely to have lived longer with HIV, report more bothersome symptoms, be prescribed more benzodiazepines and opioids, and consume less nicotine and alcohol...
July 21, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28733542/use-of-a-genome-wide-haploid-genetic-screen-to-identify-treatment-predicting-factors-a-proof-of-principle-study-in-pancreatic-cancer
#8
Yuk Ting Ma, Sarah M Leonard, Naheema Gordon, Jennifer Anderton, Claire James, David Huen, Ciaran B Woodman, Daniel H Palmer
The ability to develop a comprehensive panel of treatment predicting factors would significantly improve our ability to stratify patients for cytotoxic or targeted therapies, and prevent patients receiving ineffective treatments. We have investigated if a recently developed genome-wide haploid genetic screen can be used to reveal the critical mediators of response to anticancer therapy. Pancreatic cancer is known to be highly resistant to systemic therapy. Recently epigenetic changes have been shown to be a key determinant in the maintenance of subpopulations of cancer cells with high-level resistance to cytotoxic therapy...
June 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28733356/steady-state-free-ca2-in-astrocytes-is-decreased-by-experience-and-impacts-arteriole-tone
#9
Eslam M F Mehina, Ciaran Murphy-Royal, Grant R Gordon
Astrocytes can control basal synaptic strength and arteriole tone via their resting Ca2+ activity. However, whether resting astrocyte Ca2+ can adjust to a new steady-state level, with an impact on surrounding brain cells, remains unknown. Using two-photon Ca2+ imaging in male rat acute brain slices of the somatosensory neocortex, we found that theta burst neural activity produced an unexpected long-lasting reduction in astrocyte free Ca2+ in the soma and endfeet. The drop in intracellular Ca2+ was attenuated by antagonists targeting multiple ionotropic and metabotropic glutamate receptors, and intracellular cascades involved Ca2+ stores and nitric oxide...
July 21, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28730861/comparative-outcomes-in-children-and-adults-with-anti-n-methyl-d-aspartate-anti-nmda-receptor-encephalitis
#10
Eliza Gordon-Lipkin, Anusha K Yeshokumar, Deanna Saylor, Ana Arenivas, John C Probasco
This study compared neurologic disability and adaptive function in children and adults >1 year following anti- N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis diagnosis. Retrospective record review identified 12 patients with anti-NMDAR encephalitis. At last follow-up, all surviving patients had "good" modified Rankin Score (0-2). Four children, 6 adults, and their families participated in a telephone interview. Median duration since diagnosis was similar for children (2.42 years, interquartile range 2...
January 1, 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/28730199/the-amorphous-state-first-principles-derivation-of-the-gordon-taylor-equation-for-direct-prediction-of-the-glass-transition-temperature-of-mixtures-estimation-of-the-crossover-temperature-of-fragile-glass-formers-physical-basis-of-the-rule-of-2-3
#11
Peter J Skrdla, Philip D Floyd, Philip C Dell'Orco
Predicting the glass transition temperature (Tg) of mixtures has applications that span across industries and scientific disciplines. By plotting experimentally determined Tg values as a function of the glass composition, one can usually apply the Gordon-Taylor (G-T) equation to determine the slope, k, which subsequently can be used in Tg predictions. Traditionally viewed as a phenomenological/empirical model, this work proposes a physical basis for the G-T equation. The proposed equations allow for the calculation of k directly and, hence, they determine/predict the Tg values of mixtures algebraically...
July 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28729458/the-junior-faculty-networking-cohort-filling-a-gap-in-support-for-our-community
#12
EDITORIAL
Sharona E Gordon
JGP, in partnership with the Society of General Physiologists, announces a new networking and mentoring program for junior faculty.
July 20, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28729329/fluids-in-sepsis-and-septic-shock-fissh-protocol-for-a-pilot-randomised-controlled-trial
#13
Bram Rochwerg, Tina Millen, Peggy Austin, Michelle Zeller, Frédérick D'Aragon, Roman Jaeschke, Marie-Hélène Masse, Sangeeta Mehta, Francois Lamontagne, Maureen Meade, Gordon Guyatt, Deborah J Cook
INTRODUCTION: Observational evidence suggests physiological benefits and lower mortality with lower chloride solutions; however, 0.9% saline remains the most widely used fluid worldwide. Given uncertainty regarding the association of lower chloride on mortality, it is unlikely that practice will change without direct randomised clinical trial (RCT) evidence. This pilot RCT will investigate the feasibility of a large-scale trial directly comparing low chloride with high chloride fluids in patients with septic shock...
July 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28729180/symptom-and-quality-of-life-improvement-in-lux-lung-8-an-open-label-phase-iii-study-of-second-line-afatinib-versus-erlotinib-in-patients-with-advanced-squamous-cell-carcinoma-of-the-lung-after-first-line-platinum-based-chemotherapy
#14
Enriqueta Felip, Vera Hirsh, Sanjay Popat, Manuel Cobo, Andrea Fülöp, Charles Dayen, José M Trigo, Richard Gregg, Cornelius F Waller, Jean-Charles Soria, Glenwood D Goss, James Gordon, Bushi Wang, Michael Palmer, Eva Ehrnrooth, Shirish M Gadgeel
INTRODUCTION: In the phase III LUX-Lung 8 trial, afatinib significantly improved progression-free survival (PFS) and overall survival (OS) versus erlotinib in patients with squamous cell carcinoma (SCC) of the lung progressing during or after platinum-based chemotherapy. Patient-reported outcomes (PROs) and health-related quality of life (QoL) in these patients are presented. PATIENTS AND METHODS: Patients (n = 795) were randomized 1:1 to oral afatinib (40 mg/d) or erlotinib (150 mg/d)...
June 23, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28729046/bone-mineralization-and-fracture-risk-assessment-in-the-pediatric-population
#15
Halley Wasserman, Catherine M Gordon
Identifying children most susceptible to clinically significant fragility fractures (low trauma fractures or vertebral compression fractures) or recurrent fractures is an important issue facing general pediatricians and subspecialists alike. Over the last decade, several imaging technologies, including dual-energy X-ray absorptiometry and peripheral quantitative computed tomography, have become useful to identify abnormal bone mineralization in children and in adolescents. This review aimed to summarize the latest literature on the utility of these modalities as they pertain to use in pediatrics...
July 17, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28728556/influence-of-staphylococcus-aureus-on-outcomes-after-valvular-surgery-for-infective-endocarditis
#16
Sang Myung Han, Robert A Sorabella, Sowmya Vasan, Mark Grbic, Daniel Lambert, Rahul Prasad, Catherine Wang, Paul Kurlansky, Michael A Borger, Rachel Gordon, Isaac George
BACKGROUND: As Staphylococcus aureus (SA) remains one of the leading cause of infective endocarditis (IE), this study evaluates whether S. aureus is associated with more severe infections or worsened outcomes compared to non-S. aureus (NSA) organisms. METHODS: All patients undergoing valve surgery for bacterial IE between 1995 and 2013 at our institution were included in this study (n = 323). Clinical data were retrospectively collected from the chart review. Patients were stratified according to the causative organism; SA (n = 85) and NSA (n = 238)...
July 20, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28727958/lipid-injectable-emulsion-survey-with-gap-analysis
#17
Michael L Christensen, Phil Ayers, Joseph I Boullata, Peggi Guenter, Kathleen M Gura, Beverly Holcombe, David S Seres, Gordon S Sacks
BACKGROUND: Lipid injectable emulsion (ILE) is an integral part of parenteral nutrition (PN), providing energy and essential fatty acids. With recent consensus recommendations for PN, clinical guidelines for ordering and preparation of PN, the U.S. Food and Drug Administration approval of new ILE products, and revised ILE labeling to include a 1.2-micron filter, a gap in current practice knowledge was apparent. MATERIALS AND METHODS: The American Society for Parenteral and Enteral Nutrition PN Safety Committee surveyed clinicians on how ILE products are prescribed, prepared, and administered to patients from neonates to adults...
July 1, 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28727869/solid-tissue-simulating-phantoms-having-absorption-at-970%C3%A2-nm-for-diffuse-optics
#18
Gordon T Kennedy, Griffin R Lentsch, Brandon Trieu, Adrien Ponticorvo, Rolf B Saager, Anthony J Durkin
No abstract text is available yet for this article.
July 1, 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28726549/homeless-veterans-experiences-with-substance-use-recovery-and-treatment-through-photo-elicitation
#19
Samuel F Sestito, Keri L Rodriguez, Shaddy K Saba, James W Conley, Michael A Mitchell, Adam J Gordon
BACKGROUND: Homeless Veterans often have addictions and comorbidities that complicate utilization of longitudinal healthcare services, such as primary care. An understanding of experiences of Veterans enrolled in a Homeless Patient Aligned Care Team (H-PACT) may improve addiction treatment engagement in these settings. We aimed to describe H-PACT Veterans' experiences with substance use (SU), substance use recovery (SUR), and substance use treatment (SUT). METHODS: Homeless Veterans were recruited from a Veteran primary care medical home clinic between September 2014 and March 2015...
July 20, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28726340/factors-influencing-property-selection-for-conservation-revolving-funds
#20
Mathew J Hardy, James A Fitzsimons, Sarah A Bekessy, Ascelin Gordon
Finding sustainable ways to increase the amount of private land protected for biodiversity is a challenge for many conservation organizations. In a number of countries, organizations use 'revolving fund' programs, whereby land is purchased, and then on-sold to conservation-minded owners with a condition to enter into a conservation covenant or easement. The proceeds from sale are then used to purchase, protect and on-sell additional properties, incrementally increasing the amount of protected private land. As the effectiveness of this approach relies upon selecting the right properties, we sought to explore the factors currently considered by practitioners and how these are integrated into decision-making...
July 20, 2017: Conservation Biology: the Journal of the Society for Conservation Biology
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