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Sentinel lymph node biopsy

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https://www.readbyqxmd.com/read/28654548/histopathologic-review-of-negative-sentinel-lymph-node-biopsies-in-thin-melanomas-an-argument-for-the-routine-use-of-immunohistochemistry
#1
Anne M Stowman, Alexandra W Hickman, Alejandro A Gru, Craig L Slingluff
Sentinel lymph node biopsy (SLNB) is performed for some thin melanomas in the presence of concerning histopathological features. There are no defined standards for how sentinel nodes should be processed to detect microscopic metastases. We compared our method of serially sectioning nodes at 2-3 mm intervals and performing one hematoxylin and eosin (H&E) slide versus multiple H&E levels and utilizing immunohistochemistry (IHC). This was a retrospective review of a prospectively collected database identified patients with thin melanomas treated with wide local excision and SLNB between 1995 and 2010...
August 2017: Melanoma Research
https://www.readbyqxmd.com/read/28654463/fatty-acid-synthase-and-acetyl-coa-carboxylase-are-expressed-in-nodal-metastatic-melanoma-but-not-in-benign-intracapsular-nodal-nevi
#2
Jad Saab, Maria Laureana Santos-Zabala, Massimo Loda, Edward C Stack, Travis J Hollmann
BACKGROUND: Melanoma is a potentially lethal form of skin cancer for which the current standard therapy is complete surgical removal of the primary tumor followed by sentinel lymph node biopsy when indicated. Histologic identification of metastatic melanoma in a sentinel node has significant prognostic and therapeutic implications, routinely guiding further surgical management with regional lymphadenectomy. While melanocytes in a lymph node can be identified by routine histopathologic and immunohistochemical examination, the distinction between nodal nevus cells and melanoma can be morphologically problematic...
June 13, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28650537/predictors-of-false-negative-sentinel-lymph-node-biopsy-in-trunk-and-extremity-melanoma
#3
Andrew J Sinnamon, Madalyn G Neuwirth, Edmund K Bartlett, Salman Zaheer, Mark S Etherington, Xiaowei Xu, David E Elder, Brian J Czerniecki, Douglas L Fraker, Giorgos C Karakousis
BACKGROUND: Nodal recurrence following negative sentinel lymph node biopsy (SLNB) for melanoma is known as false-negative (FN) SLNB. Risk factors for FN SLNB among patients with trunk and extremity melanoma have not been well-defined. METHODS: After retrospective review, SLNB procedures were classified FN, true positive (TP; positive SLNB), or true negative (TN; negative SLNB without recurrence). Factors associated with high false negative rate (FNR) and low negative predictive value (NPV) were identified by comparing FNs to TPs and TNs, respectively...
June 26, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28650410/identification-of-risk-factors-in-lymphatic-surgeries-for-melanoma-a-national-surgical-quality-improvement-program-review
#4
Mona Ascha, Mustafa S Ascha, Brian Gastman
INTRODUCTION: Sentinel lymph node biopsy (SLNB) and lymphadenectomy (LAD) are commonly performed in the staging and care of patients with malignant melanoma. These procedures are accompanied by complications that may result in hospital readmission, negatively affecting patient outcomes and potentially affecting surgical procedure reimbursement. The National Surgical Quality Improvement Program (NSQIP) database offers a large data set allowing physicians to evaluate 30-day readmission for surgical complications...
June 23, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28650355/axillary-dissection-and-nodal-irradiation-can-be-avoided-for-most-node-positive-z0011-eligible-breast-cancers-a-prospective-validation-study-of-793-patients
#5
Monica Morrow, Kimberly J Van Zee, Sujata Patil, Oriana Petruolo, Anita Mamtani, Andrea V Barrio, Deborah Capko, Mahmoud El-Tamer, Mary L Gemignani, Alexandra S Heerdt, Laurie Kirstein, Melissa Pilewskie, George Plitas, Virgilio S Sacchini, Lisa M Sclafani, Alice Ho, Hiram S Cody
OBJECTIVE: To determine rates of axillary dissection (ALND) and nodal recurrence in patients eligible for ACOSOG Z0011. BACKGROUND: Z0011 demonstrated that patients with cT1-2N0 breast cancers and 1 to 2 involved sentinel lymph nodes (SLNs) having breast-conserving therapy had no difference in locoregional recurrence or survival after SLN biopsy alone or ALND. The generalizability of the results and importance of nodal radiotherapy (RT) is unclear. METHODS: Patients eligible for Z0011 had SLN biopsy alone...
July 22, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28649094/current-management-of-pregnancy-associated-breast-cancer
#6
H Hy Yu, P Sy Cheung, R Cy Leung, T N Leung, W H Kwan
Pregnancy-associated breast cancer is the most common malignancy during pregnancy with an expected rise in incidence. The belief in the need for termination of pregnancy and that chemotherapy is contra-indicated during pregnancy is challenged by recent evidence. Patients can consider breast-conserving surgery and sentinel lymph node biopsy with acceptably low fetal risk from radiation exposure. A range of chemotherapeutics is possible in the second trimester in terms of drug class and frequency. Hormone therapy and monoclonal antibody therapy are contra-indicated during pregnancy and lactation...
June 26, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28647776/sentinel-node-biopsy-for-axillary-management-after-neoadjuvant-therapy-for-breast-cancer-a-single-center-retrospective-analysis-with-long-follow-up
#7
Yoshinari Ogawa, Katsumi Ikeda, Chika Watanabe, Yuri Kamei, Shinya Tokunaga, Yuko Tsuboguchi, Takeshi Inoue, Hiroko Fukushima, Makoto Ichiki
PURPOSE: Sentinel node biopsy (SNB) after neoadjuvant therapy (NAT) for breast cancer remains controversial. We conducted a retrospective study of patients who underwent SNB after NAT to evaluate the effectiveness of this procedure. METHODS: A consecutive 105 women with locally advanced breast cancer (cT1-4, cN0-3, M0) were treated with NAT between 2006 and 2015. The subjects were 80 of these patients who became or remained clinically node-negative after NAT, 53 of whom had axillary management determined by SNB (group A) and the other 27 underwent axillary lymph node dissection (ALND) without SNB (group B)...
June 24, 2017: Surgery Today
https://www.readbyqxmd.com/read/28644540/cytokeratin-19-expression-in-early-oral-squamous-cell-carcinoma-and-their-metastasis-inadequate-biomarker-for-one-step-nucleic-acid-amplification-implementation-in-sentinel-lymph-node-biopsy-procedure
#8
Rob Noorlag, Robert J J van Es, Remco de Bree, Stefan M Willems
BACKGROUND: Intraoperative analysis of lymph nodes during a sentinel lymph node biopsy (SLNB) procedure could result in one-step surgery for early oral squamous cell carcinoma (OSCC) with an occult nodal metastasis. One-step nucleic acid amplification rapidly detects cytokeratin 19 (CK19) RNA with high accuracy. Sensitivity and specificity of CK19 expression in OSCC was evaluated. METHODS: Immunohistochemical CK19 expression was done in 207 patients with OSCC with 65 cases of paired nodal metastases...
June 23, 2017: Head & Neck
https://www.readbyqxmd.com/read/28644220/completion-lymph-node-dissection-in-patients-with-melanoma-and-positive-sentinel-lymph-node-biopsy
#9
Jacqueline Link
Melanoma is a highly aggressive cancer that represents a significant disease burden, making diagnosis and appropriate control of disease vital for improving morbidity and mortality. The most recent guidelines for melanoma treatment advise performing a sentinel lymph node biopsy for intermediate thickness melanomas, with subsequent completion lymph node dissection (CLND) if sentinel nodes are positive. This guideline is controversial due to the limited availability of data on this topic. CLND is an extensive surgery with known risks and complications and a small survival benefit...
July 2017: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/28644156/clinical-case-of-the-month-a-57-year-old-man-with-an-axillary-mass
#10
Palak Desai, Andrew Myers, Brian Boulmay, Fred A Lopez
A 57-year-old man presented to the surgical oncology clinic with a mildly tender mass under his right arm. Four years prior, the patient had a melanoma removed from his right shoulder along with an ipsilateral right axillary sentinel lymph sampling. Computed tomography (CT) scan was negative for metastatic disease at that time. The patient did not undergo completion axillary node dissection and was lost to follow-up. The patient was originally from Australia, did not tan but reported multiple sunburns before age 18...
May 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28640533/high-risk-squamous-cell-carcinoma-of-the-ear-a-potential-role-for-sentinel-node-biopsy
#11
Suzanne Beecher, Paula F Wrafter, Cormac W Joyce, Padraic J Regan, Jack L Kelly
BACKGROUND: Squamous cell carcinomas (SCCs) of the external ear have a significant rate of metastasis. The purpose of this study was to present analyzed factors associated with auricular SCC metastasis in order to identify a group that may benefit from sentinel lymph node biopsy (SLNB). METHODS: We performed a retrospective review of all operable SCCs between 2009 and 2014. The association between high-risk features and metastasis were analyzed. RESULTS: One hundred eighty-nine auricular SCCs were excised...
June 22, 2017: Head & Neck
https://www.readbyqxmd.com/read/28629690/axillary-lymph-node-sonographic-features-and-breast-tumor-characteristics-as-predictors-of-malignancy-a-nomogram-to-predict-risk
#12
Patricia Akissue de Camargo Teixeira, Luciano F Chala, Carlos Shimizu, José R Filassi, Jonathan Y Maesaka, Nestor de Barros
The purpose of this study was to build a mathematical model to predict the probability of axillary lymph node metastasis based on the ultrasonographic features of axillary lymph nodes and the tumor characteristics. We included 74 patients (75 axillae) with invasive breast cancer who underwent axillary ultrasonography ipsilateral to the tumor and fine-needle aspiration of one selected lymph node. Lymph node pathology results from sentinel lymph node biopsy or surgical dissection were correlated with lymph node ultrasonographic data and with the cytologic findings of fine-needle aspiration...
June 16, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28628677/impact-of-a-31-gene-expression-profiling-test-for-cutaneous-melanoma-on-dermatologists-clinical-management-decisions
#13
Aaron S Farberg, Alex M Glazer, Richard White, Darrell S Rigel
<p>Importance: Current guidelines for cutaneous malignant melanoma (CMM) provide general recommendations regarding surveillance while indicating that management should be tailored to patients' individual probability of recurrence. A 31-gene expression profile (31-GEP) test to predict metastatic risk has been previously validated, and classifies patients as either Class 1 (low risk) or Class 2 (high risk).</p> <p>Objective: To determine the impact of the 31-GEP test's result on clinical decision-making...
May 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28626898/plk-1-immunoreactivity-is-associated-with-metastases-in-cutaneous-melanoma
#14
Maciej Kaczorowski, Tomasz Borowiec, Piotr Donizy, Konrad Pagacz, Wojciech Fendler, Artur Lipinski, Agnieszka Halon, Rafal Matkowski
BACKGROUND: PLK-1 is one of the key regulators of cell cycle progression. Increased expression of PLK-1 was observed in several tumor types. METHODS: We immunohistochemically assessed PLK-1 expression in neoplastic and stromal compartments of 96 cutaneous melanomas, and analyzed associations between PLK-1 expression and clinicopathological characteristics. RESULTS: PLK-1 expression in cancer cells was not associated with basic clinical (e...
June 19, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28626128/a-case-of-matrix-producing-carcinoma-of-the-breast
#15
Yuzuru Inoue, Fumi Joden, Kei Yabuki, Nagahiro Sato, Noritaka Minagawa, Takefumi Katsuki, Norihiro Sato, Takahisa Nagata, Kazunori Shibao, Atsuji Matsuyama, Takatoshi Aoki, Keiji Hirata
A 61-year-old woman was referred to our hospital because of a right breast mass. A 19 mm hard mass was palpable in the A area of the right breast. A contrast-enhanced MRI showed rim enhancement at the peripheral region of the tumor, which was thought to represent the carcinoma component mainly at the periphery and the matrix component inside the tumor. A low density mass with rim enhancement at the peripheral region was observed in a contrast-enhanced CT, the same as in the MRI. Neither axillary lymph node metastasis nor distant metastasis was observed...
2017: Journal of UOEH
https://www.readbyqxmd.com/read/28625757/sentinel-node-biopsy-status-is-strongly-predictive-of-survival-in-cutaneous-melanoma-extended-follow-up-of-oxford-patients-from-1998-to-2014
#16
David R Thomson, Milap G Rughani, Rachel Kuo, Oliver C S Cassell
INTRODUCTION: Sentinel lymph node biopsy (SLNB) is widely used as a key investigatory tool for cutaneous melanoma, with results incorporated into the latest AJCC staging guidelines. We present the results of our extended follow-up of sentinel lymph node biopsy for melanoma over a sixteen-year period. METHODS: Data were collected prospectively from June 1998 to December 2014 from a single tertiary skin cancer referral centre. Chi-squared analysis was used to analyse patient demographics and primary tumour pathology...
May 27, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28623243/metaplastic-breast-carcinoma-with-chondroid-differentiation-a-rare-variant-of-infiltrative-carcinoma-in-a-38-year-old-woman
#17
Shokouh Taghipour Zahir, Mostafa Javannejad
Metaplastic breast carcinoma (MBC) is a rare type of invasive breast carcinoma, and chondroid differentiation is even rarer. Here we report a case of MBC with extensive chondroid differentiation in a 38-year-old woman who presented with a lump in her left breast. Ultrasound findings were most compatible with those of giant fibroadenoma. A histopathological examination revealed a malignant lesion comprising neoplastic epithelial cells arranged in solid nests, with large areas of chondroid differentiation. Neoplastic chondroid cells exhibited a positive reaction for S-100, patchy positive reaction for pan-cytokeratin (AE1/AE3) and negative reaction for epithelial membrane antigen...
June 15, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28621194/-breast-reconstruction-surgery-with-endoscopic-assisted-latissimus-dorsi-muscle-flap
#18
Gábor Bognár, András Novák, György Ledniczky, Gábor István
The results obtaining with breast reconstruction surgery are not always satisfactory for the patients. Reconstruction with pure latissimus dorsi flap is useful option and due to endoscopic harvest large scar on the back can be avoided. The skin sparing mastectomy and even the sentinel lymph node biopsy or lymphadenectomy can be performed using a single incision in the axilla. Also the immediate reconstruction with endoscopically assisted harvest of the latissimus dorsi muscle flap in selective cases can be done using the same incision...
June 2017: Magyar Sebészet
https://www.readbyqxmd.com/read/28616598/laparoscopic-sentinel-node-navigation-surgery-for-early-gastric-cancer
#19
REVIEW
Shinichi Kinami, Takeo Kosaka
Currently, the most accurate method for identifying lymph node metastasis is intraoperative diagnosis by sentinel node (SN) biopsy. Based on the SNNS study-a recent large-scale, nationwide, multicenter prospective study-the SN concept seems to be scientifically valid in patients with early gastric cancer. SN biopsy is a multistep technique consisted of six essential elements: indication, the selection of a tracer, a proper tracer injection method, the objective detection of SNs, a reliable biopsy technique, and the precise detection of nodal metastasis...
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28612483/laparoscopic-pelvic-lymph-node-dissection-for-malignant-foot-melanoma
#20
Sho Yamada, Masanori Kotake, Daiki Kakiuchi, Kengo Hayashi, Masahiro Hada, Yousuke Kato, Kaeko Oyama, Takuo Hara, Haruhisa Taizo
A 39 year-old woman with malignant foot melanoma underwent wide excision of the primary tumor with a safety margin and sentinel lymph node biopsy (SLNB) for the right inguinal lymph node. SLNB was positive and a computed tomography (CT) scan revealed right iliac lymph node swelling. Positron emission tomography computed tomography (PET-CT) scan of the lymph nodes revealed abnormal uptake of fluorodeoxyglucose (FDG). We performed a laparoscopic pelvic lymph node obturator, iliac lymph node) dissection. During the operation, several black lymph nodes were observed in the iliac lymph node...
June 13, 2017: Asian Journal of Endoscopic Surgery
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