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magnesium depression

Anna Serefko, Aleksandra Szopa, Ewa Poleszak
Magnesium is one of the most important elements in the human body and is involved in a number of biochemical processes crucial for the proper functioning of the cardiovascular, alimentary, endocrine, and osteoarticular systems. It also plays a vital modulatory role in brain biochemistry, influencing several neurotransmission pathways associated with the development of depression. Personality changes, including apathy, depression, agitation, confusion, anxiety, and delirium are observed when there is a deficiency of this element...
March 1, 2016: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
Miguel Ángel Martínez-González, Almudena Sánchez-Villegas
A higher magnesium intake may reduce the risk of depression. We analyzed this association in the SUN Mediterranean cohort with an expanded sample size (n = 15,836) and a long follow-up (median = 10.2 y). We followed 9,289 women (age = 34.8, SD = 10.4) and 6,547 men (age = 42.8, SD = 13.1) initially free of any history of depression for a new-onset of medically diagnosed depression (maximum follow-up = 15.9 y). All participants in this cohort were university educated. We systematically reviewed previous studies relating magnesium to depression...
March 1, 2016: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
Sander Bruun, Sarah L Harmer, Georgios Bekiaris, Wibke Christel, Lucia Zuin, Yongfeng Hu, Lars Stoumann Jensen, Enzo Lombi
Biochar application to agricultural land has been proposed as a means for improving phosphorus (P) availability in soil. The purpose of the current study was to understand how pyrolysis temperature affects P speciation in biochar and how this affects availability of P in the amended soil. Biochar was produced at different temperatures from digestate solids. The primary species of P in digestate solids were simple calcium phosphates. However, a high co-occurrence of magnesium (Mg) and P, indicated that struvite or other magnesium phosphates may also be important species...
November 22, 2016: Chemosphere
Ramin Mehrdad, Noroja Ghadiri Asli, Gholamreza Pouryaghoub, Maryam Saraei, Firoozeh Salimi, Mostafa Nejatian
OBJECTIVES: Identifying factors predictive of early return to work in patients who underwent a coronary artery bypass graft surgery (CABG). MATERIAL AND METHODS: Two hundred twenty-six working patients who volunteered and underwent a primary coronary artery bypass surgery between September 2013 and May 2014 were selected for the study and followed up for 6 months. Predictors of early return to work (RTW) (within 2 months) were analyzed from variables in a prospectively collected database and the 36-Item Short Form Health Survey (SF-36) questionnaire carried out in the hospital and rehabilitation center as well as from the follow-up performed via the phone...
November 18, 2016: International Journal of Occupational Medicine and Environmental Health
Syed A Mehdi, Steven E Atlas, Sidra Qadir, Dominique Musselman, Sharon Goldberg, Judi M Woolger, Raul Corredor, Muhammad Hasnain Abbas, Leopoldo Arosemena, Simone Caccamo, Carmen Campbell, Ashar Farooqi, Jinrun Gao, Janet Konefal, Lucas C Lages, Laura Lantigua, Johanna Lopez, Vanessa Padilla, Ammar Rasul, Anna M Ray, Herbert Simões, Eduard Tiozzo, John E Lewis
AIM: Treatment-resistant depression patients are more likely to suffer from comorbid physical and mental disorders, experience marked and protracted functional impairment, and incur higher healthcare costs than non-affected individuals. Magnesium sulfate is a treatment option that may offer great potential for patients with treatment-resistant depression based on prior work in animals and humans. METHODS: Twelve subjects with mild or moderate treatment-resistant depression were randomized into a double-blind crossover trial to receive an infusion of 4 gram of magnesium sulfate in 5% dextrose or placebo infusion of 5% dextrose with a 5-day washout in between the 8-day intervention period...
November 10, 2016: Psychiatry and Clinical Neurosciences
Bingrong Li, Jing Lv, Weijing Wang, Dongfeng Zhang
OBJECTIVE: Several epidemiological studies have evaluated the associations between dietary magnesium (Mg) and calcium (Ca) intake and the risk of depression. However, the results of these studies remain controversial. Thus, we performed a meta-analysis to explore these associations and to investigate the possible dose-response relationship between dietary Mg intake and risk of depression. METHODS: MEDLINE, Web of Science, Embase, Cochrane CENTRAL, CINAHL database, Chinese National Knowledge Infrastructure, Wan fang databases and Databases of Chinese Scientific and Technical Periodicals were searched for eligible publications up to September 2016...
November 1, 2016: Australian and New Zealand Journal of Psychiatry
Mohammed Al-Hariri
Diabetic patients have increased fracture risk. The pathogenesis underlying the status of bone alterations in diabetes mellitus is not completely understood but is multifactorial. The major deficits appear to be related to a deficit in mineralized surface area, a decrement in the rate of mineral apposition, deceased osteoid surface, depressed osteoblast activity, and decreased numbers of osteoclasts due to abnormal insulin signaling pathway. Other prominent features of diabetes mellitus are an increased urinary excretion of calcium and magnesium, accumulation of advanced glycation end products, and oxidative stress leading to sweet bones (altered bone's strength, metabolism, and structure)...
2016: Journal of Diabetes Research
S Gibiino, A Trappoli, B Balzarro, A R Atti, D De Ronchi
A 71-year-old man developed coma with severe respiratory failure, hypotension, and tachycardia induced by the intentional ingestion of quetiapine fumarate extended release (XR) 20 g. At the time, he had been treated for bipolar depression with venlafaxine 75 mg/day, lamotrigine 100 mg/day, pregabalin 75 mg/day, and quetiapine XR 400 mg/day for approximately 1 year. Comorbidities were hypertension treated with metoprolol, diabetes mellitus type 2 treated with metformin, and benign prostatic hyperplasia treated with silodosin...
December 2015: Drug Safety—Case Reports
Sara Razmjou, Darcy Litteljohn, Chris Rudyk, Shuaib Syed, Melanie Clarke, Rowan Pentz, Zach Dwyer, Shawn Hayley
Approximately one-third of patients with major depressive disorders (MDDs) are resistant to current treatment methods, and the majority of cases relapse at some point during therapy. This has resulted in novel treatments being adopted, including subanesthetic doses of ketamine, which affects aberrant neuroplastic circuits, glutamatergic signaling, and the production of brain-derived neurotrophic factor. Ketamine rapidly relieves depressive symptoms in treatment-resistant major depressive disorder patients with effects that last for up to 2 weeks even after a single administration...
2016: Neuropsychiatric Disease and Treatment
Fatemeh Edalati Fard, Mojgan Mirghafourvand, Sakineh Mohammad-Alizadeh Charandabi, Azizeh Farshbaf-Khalili, Yousef Javadzadeh, Hanieh Asgharian
Postpartum anxiety and depression are prevalent disorders. The authors of this study aimed to determine the effects of zinc and magnesium supplements on depressive symptoms and anxiety in postpartum women referred to three governmental, educational hospitals in Tabriz, Iran during 2014-2015. In this triple-blind, randomized, controlled clinical trial, the participants were randomly assigned to the zinc sulfate, magnesium sulfate, and placebo groups (n = 33 per group). The intervention groups received a 27-mg zinc sulfate tablet or 320-mg magnesium sulfate tablet per day for 8 weeks, whereas the control group received a placebo tablet each day during the same period...
September 12, 2016: Women & Health
Akira Mochizuki, Chie Yahata, Hung Takai
Magnesium alloys have been investigated by many researchers as a new absorbable biomaterial owing to their excellent degradability with non-maleficence or low-maleficence in living tissues. In the present work, the in vitro cytocompatibility of an Magnesium alloy was investigated by culturing cells directly on it. Investigations were carried out in terms of the cell viability along with the use of scanning electron microscopy to observe its morphology. The cell lines used were derived from fibroblast, endothelial, and smooth muscle cells...
September 2016: Journal of Materials Science. Materials in Medicine
Handan Aydin Vural, Lora Koenhemsi, Remzi Gonul, Hasret Demircan Yardibi, Tevfik Gulyasar, Erman Or, Gulhan Turkay Hosturk, Bora Barutcu, Huriye Balci
OBJECTIVE: To study the effect of isoxsuprine hydrochloride on the ischaemic electrocardiographic change and trace element status in sheep. METHODS: This study was conducted from March 16 to 23, 2012, at Istanbul University, Turkey, and comprised sheep aged 6 months. The animals were divided into two equal groups. The control group was fed a standard diet and had free access to water. In the experimental group, isoxsuprine hydrochloride was injected at a dose of 0...
August 2016: JPMA. the Journal of the Pakistan Medical Association
Katharine T Briggs, Gary G Giulian, Gong Li, Joseph P Y Kao, John P Marino
Lithium carbonate, a drug for the treatment of bipolar disorder, provides mood stability to mitigate recurrent episodes of mania and/or depression. Despite its long-term and widespread use, the mechanism by which lithium acts to elicit these psychological changes has remained unknown. Using nuclear magnetic resonance (NMR) methods, in this study we characterized the association of lithium with adenosine triphosphate (ATP) and identified a bimetallic (Mg·Li) ATP complex. Lithium's affinity to form this complex was found to be relatively high (Kd ∼1...
July 26, 2016: Biophysical Journal
Bartłomiej Pochwat, Gabriel Nowak, Bernadeta Szewczyk
BACKGROUND: The preclinical results indicate that magnesium, an N-methyl-d-aspartate receptor (NMDAR) blocker has anxiolytic and antidepressant-like activity. One of the mechanisms involved in these activities is modulation of glutamate, γ-aminobutyric acid (GABA) system. Based on this, the aim of the present study was to investigate the effect of magnesium on the level of glutamic acid decarboxylase-67kDa (GAD-67) in the different brain areas in the chronic mild stress (CMS) and olfactory bulbectomy (OB) models of depression in rats...
October 2016: Pharmacological Reports: PR
Luisa Muraro, Laura Longo, Federico Geraldini, Andrea Bortot, Andrea Paoli, Annalisa Boscolo
Caffeine is arguably the most widely used stimulant drug in the world. Here we describe a suicide attempt involving caffeine overdose whereby the patient's severe intoxication was successfully treated with the prompt infusion of Intralipid. A 19-year-old man was found in an agitated state at home by the volunteer emergency team about 1 h after the intentional ingestion of 40 g of caffeine (tablets). His consciousness decreased rapidly, followed quickly by seizures, and electrocardiographic monitoring showed ventricular fibrillation...
October 2016: Journal of Anesthesia
Fatemeh Edalati-Fard, Mojgan Mirghafourvand, Sakineh Mohammad-Alizadeh-Charandabi, Azizeh Farshbaf-Khalili
OBJECTIVE: According to the World Health Organization, depression will be the second prevalent problem after ischemic heart diseases by the year 2020. Postpartum depression (PPD) as a major depressive episode has devastating impacts on the health of mother, newborn, infant, and even the whole family. This study was conducted to investigate the relationship of zinc and magnesium serum levels with PPD, as one of the commonly assumed causes of depression. METHODS: This cross-sectional study was done on 122 postpartum women aged 18 years and more in two educational hospitals and one non-educational hospital in Tabriz-Iran, 2015...
2016: Global Journal of Health Science
Suchita Parikh, Snehlata Tavri, Shubha Mohite
Posterior reversible encephalopathy syndrome (PRES) is a clinicoradiologic syndrome of headache, visual changes, altered mental status and seizures with radiologic findings of posterior cerebral white matter edema. It is seen in hypertensive encephalopathy, renal failure, and autoimmune disorders or in patients on immunosuppressants. We report a case of 24-year-old primigravida who presented at term with sudden onset hypertension, neurological deficits, and an episode of the visual blackout. Magnetic resonance imaging showed features suggestive of PRES...
May 2016: Anesthesia, Essays and Researches
Long Ma, Jinglu Wu, Jilili Abuduwaili, Wen Liu
Geochemical concentrations were extracted for a short sediment core from Ebinur Lake, located in arid northwest China, and mathematical methods were used to demonstrate the complex pattern of the geochemical anomalies resulting from the temporal changes in natural and anthropogenic forces on the lake sediments. The first element assemblage (C1) (aluminum, potassium, iron, magnesium, beryllium, etc.) was predominantly terrigenous; among the assemblage, total phosphorus and titanium were generally consistent with aluminum except with regards to their surface sequences, which inferred the differences of source regions for terrigenous detrital material led to this change around ca...
2016: PloS One
Miroslava Vosahlikova, Petr Svoboda
Mood disorders are relatively common serious human diseases for which there is often no ideal pharmacotherapy. Basic characteristic of these diseases is affective disorder shifting the mood of the patient to depression (together with anxiety or not) or towards to euphoria. Available drugs are usually divided into two groups - mood stabilizers, which are used primarily to treat bipolar disorder, and antidepressants for the treatment of unipolar depression. Lithium is still recommended as the first choice for dealing with bipolar disorder...
2016: Acta Neurobiologiae Experimentalis
Naoya Fukushima, Kenji Nanao, Hiroyuki Fukushima, Akira Namera, Masaru Miura
UNLABELLED: It is known that tricyclic antidepressants induce long QT intervals associated with forms of life-threatening arrhythmia such as torsades de pointes (TdP), and these adverse effects may also occur in neonates whose mothers take tricyclic antidepressants. We report a neonatal case of prolonged QT interval and TdP caused by clomipramine that was transferred transplacentally from the mother. Administration of magnesium sulfate was effective to abolish TdP. CONCLUSION: When mothers take tricyclic antidepressants during pregnancy, their newborns should be watched carefully for drug-induced long QT syndrome and TdP...
August 2016: European Journal of Pediatrics
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