keyword
https://read.qxmd.com/read/38493659/the-association-of-sleep-duration-and-leukocyte-telomere-length-in-middle-aged-and-young-old-adults-a-cross-sectional-study-of-uk-biobank
#1
JOURNAL ARTICLE
Yuchun Zhang, Yuanting Zhu, Xiaojun Zhang, Chunhao Li, Hongna Fu, Luyang Lin, Zhen Yang, Bo Zhang
BACKGROUND: The relationships between sleep duration and aging-associated diseases are intricate. Leukocyte telomere length (LTL) is a biomarker of aging, while the association of sleep duration and LTL is unclear. METHODS: The 310,091 study participants from UK Biobank were enrolled in this cross-sectional study. Restricted cubic splines (RCS) analysis was firstly performed to assess the nonlinear relationship between sleep duration and LTL. Sleep duration was then categorized into three groups: <7 h (short sleep duration), 7-8 h (reference group), and >8 h (long sleep duration) and multiple linear regression was applied to analyze the association of short sleep and long sleep duration with LTL...
March 7, 2024: Sleep Medicine
https://read.qxmd.com/read/38365769/association-between-modifiable-lifestyle-factors-and-telomere-length-a-univariable-and-multivariable-mendelian-randomization-study
#2
JOURNAL ARTICLE
Miao Chen, Zhen Wang, Hongfei Xu, Peng Teng, Weidong Li, Liang Ma
BACKGROUND: Telomere length has long been recognized as a valuable biomarker of aging and is inversely correlated with chronological age. Various lifestyle factors have been implicated in telomere shortening or preservation; however, the association between lifestyle factors and telomere length remains controversial. To address this issue, we conducted a Mendelian randomization (MR) analysis to investigate the potential causal associations between multiple lifestyle factors and telomere length...
February 16, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38091136/the-state-of-the-lpo-aod-system-and-the-relative-length-of-telomeric-repeats-in-the-chromosomes-of-blood-leukocytes-in-obstructive-sleep-apnea-syndrome
#3
JOURNAL ARTICLE
I M Madaeva, N A Kurashova, O N Berdina, E S Titova, S I Kolesnikov, L I Kolesnikova
We analyzed the relative length of telomeric repeats in peripheral blood leukocytes and indicators of oxidative stress in 32 men (mean age 51.2±3.1 years) with obstructive sleep apnea syndrome (OSAS). The control group consisted of volunteers without OSAS. The relative length of telomeres was determined in a DNA sample isolated from venous whole blood samples. The length of telomeric repeats of chromosomes was determined using quantitative real-time PCR (3 times for each DNA sample); albumin served as an internal control...
December 13, 2023: Bulletin of Experimental Biology and Medicine
https://read.qxmd.com/read/37803147/mendelian-randomization-and-colocalization-analyses-reveal-an-association-between-short-sleep-duration-or-morning-chronotype-and-altered-leukocyte-telomere-length
#4
JOURNAL ARTICLE
Jingyi Hu, Jiawen Lu, Qiuhan Lu, Weipin Weng, Zixuan Guan, Zhenqian Wang
Observational studies suggest certain sleep traits are associated with telomere length, but the causal nature of these associations is unclear. The study aimed to determine the causal associations between 11 sleep-related traits and leukocyte telomere length (LTL) through two-sample Mendelian randomization and colocalization analyses using the summary statistics from large-scale genome-wide association studies. Univariable Mendelian randomization indicates that genetically determined short sleep is associated with decreased LTL, while morning chronotype is associated with increased LTL...
October 6, 2023: Communications Biology
https://read.qxmd.com/read/37308919/promoting-health-and-productivity-among-ageing-workers-a-longitudinal-study-on-work-ability-biological-and-cognitive-age-in-modern-workplaces-proageing-study
#5
JOURNAL ARTICLE
Matteo Bonzini, Anna Comotti, Alice Fattori, Daniele Serra, Marco Laurino, Francesca Mastorci, Pasquale Bufano, Catalina Ciocan, Luca Ferrari, Valentina Bollati, Cristina Di Tecco
BACKGROUND: Large changes in ageing population and in retirement age are increasing the number of older people in the workforce, raising many challenges for policymakers in promoting employment opportunities and health for older workers. In this respect, longitudinal assessments of workability, well-being perception and cognitive skills over time may allow to detect factors influencing workers' health. Moreover, new available molecular markers permit the measurement of biological age and age-related changes...
June 12, 2023: BMC Public Health
https://read.qxmd.com/read/37278929/association-of-telomere-length-with-cognitive-impairment
#6
JOURNAL ARTICLE
Yevhenii Diukov, Natalia Bachinskaya, Andrii Dzobak, Victor Kholin, Yevheniia Kyriachenko, Oleksii Barsukov, Oksana Zabuha, Dmytro Krasnienkov
Telomere attrition is attributed to Alzheimer's disease (AD), major depressive disorder, stress levels, physical inactivity, short sleep duration, and reduced educational abilities. In this article, we tried to assess the association between the telomere length in peripheral blood leukocytes and level of cognitive impairment and its dependence on age and sex. Healthy subjects and patients with amnestic mild cognitive impairment (aMCI) and different AD stages were recruited in the study. All patients were assessed by the same standard diagnostic procedure, including neurological examination-Mini-Mental State Examination (MMSE)...
June 6, 2023: Journal of Molecular Neuroscience: MN
https://read.qxmd.com/read/37230863/associations-of-self-reported-sleep-duration-and-sleep-quality-during-pregnancy-with-newborn-telomere-length
#7
JOURNAL ARTICLE
Qing Liu, Lulu Song, Gaojie Fan, Mingyang Wu, Jianing Bi, Luli Xu, Chao Xiong, Wei Xia, Zhongqiang Cao, Shunqing Xu, Youjie Wang
BACKGROUND: Telomere length (TL) at birth is considered a potential biomarker for lifelong health. Although maternal sleep disturbance has been linked to a series of adverse pregnancy outcomes, evidence on the effect of maternal sleep on newborn TL remains scarce. Therefore, we aim to investigate the association of maternal sleep duration and sleep quality with newborn TL. METHODS: A total of 742 mother-newborn pairs were recruited from Wuhan Children's Hospital between November 2013 and March 2015...
May 23, 2023: Sleep Health
https://read.qxmd.com/read/36691437/the-association-between-sleep-quality-and-telomere-length-a-systematic-literature-review
#8
REVIEW
Debbie Sabot, Rhianna Lovegrove, Peta Stapleton
Several sleep parameters present an elevated risk for processes that contribute to cellular aging. Short sleep duration, sleep apnoea, and insomnia are significantly associated with shorter telomeres, a biological marker of cellular aging. However, there has been no review or analysis of studies that have examined the association between the psychological construct of sleep quality and telomere length. The present study aimed to provide a systematic review of the association between sleep quality and telomere length...
March 2023: Brain, behavior, & immunity health
https://read.qxmd.com/read/36674498/low-magnesium-in-conjunction-with-high-homocysteine-and-less-sleep-accelerates-telomere-attrition-in-healthy-elderly-australian
#9
JOURNAL ARTICLE
Varinderpal S Dhillon, Permal Deo, Philip Thomas, Michael Fenech
The relationship between sleep and micronutrients, including magnesium, is implicated in its regulation. The effects of low magnesium and other micronutrients on sleep disruption and telomere loss are not well understood. The present study was carried out in 172 healthy elderly subjects from South Australia. Plasma micronutrients including magnesium were measured. Each participant provided information about their sleep hours (&lt;7 h or ≥7 h). Lymphocyte telomere length (TL) was measured by real-time qPCR assay...
January 4, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36537264/epigenomic-links-between-social-determinants-of-health-and-symptoms-a-scoping-review
#10
REVIEW
Mitali Ray, McKenzie K Wallace, Susan C Grayson, Meredith H Cummings, Jessica A Davis, Jewel Scott, Sarah M Belcher, Tara S Davis, Yvette P Conley
Social determinants of health (SDoH) impact health and wellness. The link between SDoH and adverse health outcomes, including symptom occurrence and severity, may be explained by an individual's physiologic response to one or more SDoH. One potential mechanism underlying this physiologic response linking SDoH and symptoms is the dynamic epigenome. The purpose of this scoping review of the literature was to examine differential susceptibility for symptoms by identifying and summarizing research linking SDoH and symptoms through epigenomic mechanisms...
December 20, 2022: Biological Research for Nursing
https://read.qxmd.com/read/36497531/loneliness-depression-and-genetics-in-the-elderly-prognostic-factors-of-a-worse-health-condition
#11
JOURNAL ARTICLE
María Luisa Delgado-Losada, Jaime Bouhaben, Eduardo Arroyo-Pardo, Aránzazu Aparicio, Ana María López-Parra
Loneliness is considered a prognostic factor for poorer health status in the elderly. It is proposed to analyze the role of loneliness in health status in terms of various factors. A total of 1747 individuals from the pilot survey of the Aging in Spain Longitudinal Study (ELES-PS) were reviewed. ELES is a cross-sectional study for collecting health variables, food habits, socioeconomic data, and cognitive and functional capacities, which was carried out on a Spanish representative sample of noninstitutionalized persons of 50 years of age or older...
November 22, 2022: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/36359275/genetic-variants-of-the-tert-gene-and-telomere-length-in-obstructive-sleep-apnea
#12
JOURNAL ARTICLE
Piotr Macek, Rafal Poreba, Pawel Gac, Katarzyna Bogunia-Kubik, Marta Dratwa, Mieszko Wieckiewicz, Anna Wojakowska, Monika Michalek-Zrabkowska, Grzegorz Mazur, Helena Martynowicz
INTRODUCTION: Obstructive sleep apnea (OSA) is a worldwide breathing disorder that has been diagnosed globally in almost 1 billion individuals aged 30-69 years. It is characterized by repeated upper airway collapses during sleep. Telomerase reverse transcriptase (TERT) is involved in the prevention of telomere shortening. This prospective, observational study aimed to investigate the relationship between single nucleotide polymorphisms (SNPs) of TERT and the severity of OSA, taking into account hypertension and diabetes prevalence...
October 30, 2022: Biomedicines
https://read.qxmd.com/read/36317622/residential-green-space-and-waist-circumference-affect-telomere-shortening-in-childhood-the-longitudinal-chibs-study
#13
JOURNAL ARTICLE
Thaïs De Ruyter, Dries S Martens, Esmée M Bijnens, Tim S Nawrot, Stefaan De Henauw, Nathalie Michels
BACKGROUND: Telomere shortening, recognised as one of the most well known biomarkers of biological ageing, is susceptible to various environmental and lifestyle factors, encompassed in the exposome. Research shows that telomere length is substantially determined early in life and that exposures in childhood can have important consequences in setting telomere length later in life and thus the lifespan of an individual. We explored the associations between 17 exposures and longitudinal telomere change in a child population...
October 2022: Lancet. Planetary Health
https://read.qxmd.com/read/36254044/three-months-longitudinal-changes-in-relative-telomere-length-blood-chemistries-and-self-report-questionnaires-in-meditation-practitioners-compared-to-novice-individuals-during-midlife
#14
JOURNAL ARTICLE
Min-Kyu Sung, Eugene Koh, Yunjeong Kang, Jin-Hee Lee, Ji-Yeon Park, Ji Young Kim, So-Young Shin, Yeon-Hee Kim, Noriko Setou, Ul Soon Lee, Hyun-Jeong Yang
Aging accelerates during midlife. Researches have shown the health benefits of mind-body intervention (MBI). However, whether MBI is involved with aging process has not been well understood. In this study, we approach to examine the relations of MBI with this process by investigating an aging marker of the peripheral blood, blood chemistry, and self-report questionnaires. A quasi-experimental design was applied. Experienced MBI practitioners participated in a 3-month intensive meditation training, while the age, gender-matched MBI-naïve controls led a normal daily life...
October 14, 2022: Medicine (Baltimore)
https://read.qxmd.com/read/36182724/association-between-telomere-length-and-insomnia-a-mendelian-randomization-and-colocalization-study
#15
JOURNAL ARTICLE
Dan He, Peilin Meng, Chun'e Li, Yumeng Jia, Yan Wen, Chuyu Pan, Zhen Zhang, Jingxi Zhang, Huijie Zhang, Yujing Chen, Yijing Zhao, Xiaoyue Qin, Qingqing Cai, Wenming Wei, Sirong Shi, Xiaoge Chu, Na Zhang, Feng Zhang
BACKGROUND: Previous studies have suggested a potential association between sleep and telomere length (TL), but its genetic basis remains unclear. In this study, we aimed to explore the genetic correlation and potential causal association between TL and insomnia. METHODS: The genome-wide association study (GWAS) datasets of TL and insomnia-related traits were used, including insomnia, snoring, daytime dozing and napping. Based on the polygenic risk scores (PRS) of TL, linear regression and linkage disequilibrium score (LDSC) regression were used to preliminarily explore the association between TL and insomnia parameters in the UK Biobank cohort...
December 2022: Sleep Medicine
https://read.qxmd.com/read/35974160/children-who-sleep-more-may-have-longer-telomeres-evidence-from-a-longitudinal-population-study-in-spain
#16
JOURNAL ARTICLE
Fanny Petermann-Rocha, Desirée Valera-Gran, Paula Fernández-Pires, Dries S Martens, Jordi Júlvez, Cristina Rodríguez-Dehli, Ainara Andiarena, Manuel Lozano, Ana Fernández-Somoano, Aitana Lertxundi, Sabrina Llop, Mònica Guxens, Tim S Nawrot, Eva-María Navarrete-Muñoz
BACKGROUND: Inadequate sleep duration has been suggested as a chronic stressor associated with changes in telomere length (TL). This study aimed to explore the association between sleep duration and TL using the INMA birth cohort study data. METHODS: A total of 1014 children were included in this study (cross-sectional: 686; longitudinal: 872). Sleep duration (h/day) was reported by caregivers at 4 years and classified into tertiles (7-10 h/day; >10-11 h/day; >11-14 h/day)...
August 16, 2022: Pediatric Research
https://read.qxmd.com/read/35759567/-changes-in-the-telomeres-length-in-patients-with-obstructive-sleep-apnea-after-continuous-positive-airway-pressure-therapy-a-pilot-study
#17
JOURNAL ARTICLE
I M Madaeva, N A Kurashova, E B Ukhinov, O N Berdina, N V Semenova, V V Madaev, L I Kolesnikova, S I Kolesnikov
OBJECTIVE: To evaluate a relative telomere length in patients with obstructive sleep apnea (OSA) before and after a 6-month course of continuous positive airway pressure (CPAP) therapy. MATERIAL AND METHODS: Seventy-five men participated in the study, including 50 men with OSA (the main group 1) and 25 men without OSA (the control group). The average age in the total group was 53.4±3.6 years. Thirty-five men completed the study (the main group 2). According to the design, night polysomnography (PSG) was performed for all the subjects, blood sampling to assess the length of telomeres was carried out in the morning according to the standard method...
2022: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://read.qxmd.com/read/35691385/a-multi-exposure-approach-to-study-telomere-dynamics-in-childhood-a-role-for-residential-green-space-and-waist-circumference
#18
JOURNAL ARTICLE
Thaïs De Ruyter, Dries S Martens, Esmée M Bijnens, Tim S Nawrot, Stefaan De Henauw, Nathalie Michels
BACKGROUND: Telomeres are vulnerable to various environmental exposures and lifestyle factors, encompassed in the exposome. Recent research shows that telomere length is substantially determined early in life and that exposures in childhood may have important consequences in setting later life telomere length. OBJECTIVES: We explore in a child population the associations of 17 exposures with telomere length and longitudinal telomere change. METHODS: Children (2...
October 2022: Environmental Research
https://read.qxmd.com/read/35501726/leukocyte-telomere-dynamics-across-gestation-in-uncomplicated-pregnancies-and-associations-with-stress
#19
JOURNAL ARTICLE
Danielle M Panelli, Stephanie A Leonard, Ronald J Wong, Martin Becker, Jonathan A Mayo, Erica Wu, Anna I Girsen, Ian H Gotlib, Nima Aghaeepour, Maurice L Druzin, Gary M Shaw, David K Stevenson, Katherine Bianco
BACKGROUND: Short leukocyte telomere length is a biomarker associated with stress and morbidity in non-pregnant adults. Little is known, however, about maternal telomere dynamics in pregnancy. To address this, we examined changes in maternal leukocyte telomere length (LTL) during uncomplicated pregnancies and explored correlations with perceived stress. METHODS: In this pilot study, maternal LTL was measured in blood collected from nulliparas who delivered live, term, singleton infants between 2012 and 2018 at a single institution...
May 2, 2022: BMC Pregnancy and Childbirth
https://read.qxmd.com/read/35403707/mendelian-randomization-analyses-of-23-known-and-suspected-risk-factors-and-biomarkers-for-breast-cancer-overall-and-by-molecular-subtypes
#20
JOURNAL ARTICLE
Fa Chen, Wanqing Wen, Jirong Long, Xiang Shu, Yaohua Yang, Xiao-Ou Shu, Wei Zheng
Many risk factors have been identified for breast cancer. The potential causality for some of them remains uncertain, and few studies have comprehensively investigated these associations by molecular subtypes. We performed a two-sample Mendelian randomization (MR) study to evaluate potential causal associations of 23 known and suspected risk factors and biomarkers with breast cancer risk overall and by molecular subtypes using data from the Breast Cancer Association Consortium. The inverse-variance weighted method was used to estimate odds ratios (OR) and 95% confidence interval (CI) for association of each trait with breast cancer risk...
August 1, 2022: International Journal of Cancer. Journal International du Cancer
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