Dan He, Peilin Meng, Chun'e Li, Yumeng Jia, Yan Wen, Chuyu Pan, Zhen Zhang, Jingxi Zhang, Huijie Zhang, Yujing Chen, Yijing Zhao, Xiaoyue Qin, Qingqing Cai, Wenming Wei, Sirong Shi, Xiaoge Chu, Na Zhang, Feng Zhang
BACKGROUND: Previous studies have suggested a potential association between sleep and telomere length (TL), but its genetic basis remains unclear. In this study, we aimed to explore the genetic correlation and potential causal association between TL and insomnia. METHODS: The genome-wide association study (GWAS) datasets of TL and insomnia-related traits were used, including insomnia, snoring, daytime dozing and napping. Based on the polygenic risk scores (PRS) of TL, linear regression and linkage disequilibrium score (LDSC) regression were used to preliminarily explore the association between TL and insomnia parameters in the UK Biobank cohort...
December 2022: Sleep Medicine