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https://www.readbyqxmd.com/read/29346622/a-nosocomial-foodborne-outbreak-of-a-vim-carbapenemase-expressing-citrobacter-freundii
#1
Mathias W Pletz, Antje Wollny, Ute-Heike Dobermann, Jürgen Rödel, Svetlana Neubauer, Claudia Stein, Christian Brandt, Anita Hartung, Alexander Mellmann, Sabine Trommer, Birgit Edel, Vladimir Patchev, Oliwia Makarewicz, Jens Maschmann
Background: A foodborne outbreak of VIM carbapenemase-expressing Citrobacter freundii (CPC) occurred between February and June 2016 at a major university hospital in Germany. Methods: An explosive increase of CPC isolated from rectal swabs of patients during weekly routine screening led to the declaration of an outbreak. A hospital-wide prevalence screening was initiated as well as screening of all patients on admission and before transfer to another ward, and canteen staff, patient rooms, medical and kitchen inventory and food...
January 15, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29339782/loss-of-disease-tolerance-during-citrobacter-rodentium-infection-is-associated-with-impaired-epithelial-differentiation-and-hyperactivation-of-t-cell-responses
#2
Eugene Kang, Guangyan Zhou, Mitra Yousefi, Romain Cayrol, Jianguo Xia, Samantha Gruenheid
Citrobacter rodentium is an intestinal mouse pathogen widely used as a model to study the mucosal response to infection. Inbred mouse strains suffer one of two fates following infection: self-limiting colitis or fatal diarrheal disease. We previously reported that Rspo2 is a major genetic determinant of the outcome of C. rodentium infection; Rspo2 induction during infection of susceptible mice leads to loss of intestinal function and mortality. Rspo2 induction does not impact bacterial colonization, but rather, impedes the ability of the host to tolerate C...
January 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29327263/proton-pump-inhibitors-increase-the-susceptibility-of-mice-to-oral-infection-with-enteropathogenic-bacteria
#3
Eiichiro Yasutomi, Namiko Hoshi, Soichiro Adachi, Takafumi Otsuka, Lingling Kong, Yuna Ku, Haruka Yamairi, Jun Inoue, Tsukasa Ishida, Daisuke Watanabe, Makoto Ooi, Masaru Yoshida, Tomoya Tsukimi, Shinji Fukuda, Takeshi Azuma
BACKGROUND AND AIMS: Proton pump inhibitors (PPIs) are among the most frequently prescribed medications. Side effects including an increased risk of intestinal infections have been reported. It is assumed that PPIs can increase susceptibility to enteropathogens; however, the underlying mechanisms are unknown. Here in this study, we explored whether Lansoprazole (Laz), one of the PPIs, increases the susceptibility to enteropathogens, and further investigated the mechanism of it. METHODS: Mice were administered Laz intraperitoneally once daily and orally infected with Citrobacter rodentium (C...
January 11, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29322410/citrobacter-rodentium-infection-model-for-the-analysis-of-bacterial-pathogenesis-and-mucosal-immunology
#4
Catherine L Kennedy, Elizabeth L Hartland
Citrobacter rodentium is a mouse restricted pathogen that was originally isolated from laboratory mouse colonies and causes transmissible colonic hyperplasia, characterized by thickening of the colon and inflammation. As a natural pathogen of mice, the infection model has proven critical to the development of our understanding of the pathogenesis of enteric disease and the mucosal immune response. In addition to this, some features of disease such as dysbiosis, inflammation, and wound healing replicate features of human inflammatory bowel diseases...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29305957/isolation-of-an-incp-1-plasmid-with-mcr-1-from-a-chicken-isolate-of-citrobacter-braakii-in-china
#5
Jinxin Liu, Yanxian Yang, Yunxia Li, Dan Liu, Hongmei Tuo, Hongning Wang, Douglas R Call, Margaret Davis, Anyun Zhang
The plasmid-mediated colistin resistance gene mcr-1 has been found worldwide, but the diversity of organisms harboring this gene is unknown. In this study, twelve colistin-resistant Citrobacter spp. isolates were obtained from diseased or dead chickens in China, and PCR analysis indicated that five were positive for mcr-1. One Citrobacter braakii strain (SCC4) with a multidrug resistance phenotype was chosen for further analysis. SCC4 was resistant to ten tested antibiotics and the minimum inhibitory concentration (MIC) to colistin was >4 µg/mL...
January 3, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29305502/how-much-do-rrna-gene-surveys-underestimate-extant-bacterial-diversity
#6
Luis M Rodriguez-R, Juan C Castro, Nikos C Kyrpides, James R Cole, James M Tiedje, Konstantinos T Konstantinidis
The most common practice in studying and cataloguing prokaryotic diversity involves the grouping of sequences into Operational Taxonomic Units (or OTUs) at the 97% 16S rRNA gene sequence identity level, often using partial gene sequences such as PCR-generated amplicons. Due to the high sequence conservation of rRNA genes, organisms belonging to closely related yet distinct species may be grouped under the same OTU. However, it remains unclear how much diversity has been underestimated by this practice. To address this question, we compared OTUs of genomes defined at the 97% or 98...
January 5, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29291559/spatiotemporal-changes-in-bacterial-community-and-microbial-activity-in-a-full-scale-drinking-water-treatment-plant
#7
Luanfeng Hou, Qin Zhou, Qingping Wu, Qihui Gu, Ming Sun, Jumei Zhang
To gain insight into the bacterial dynamics present in drinking water treatment (DWT) systems, the microbial community and activity in a full-scale DWT plant (DWTP) in Guangzhou, South China, were investigated using Illumina Hiseq sequencing analyses combined with cultivation-based techniques during the wet and dry seasons. Illumina sequencing analysis of 16S rRNA genes revealed a large shift in the proportion of Actinobacteria, Proteobacteria and Firmicutes during the treatment process, with the proportion of Actinobacteria decreased sharply, whereas that of Proteobacteria and Firmicutes increased and predominated in treated water...
December 29, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29290146/multifunctional-role-of-35-kilodalton-hyaluronan-in-promoting-defense-of-the-intestinal-epithelium
#8
Sean P Kessler, Dana R Obery, Kourtney P Nickerson, Aaron C Petrey, Christine McDonald, Carol A de la Motte
Intestinal epithelium plays a critical role in host defense against orally acquired pathogens. Dysregulation of this protective barrier is a primary driver of inflammatory bowel diseases (Crohn's and ulcerative colitis) and also infant gastrointestinal infections. Previously, our lab reported that hyaluronan (HA) isolated from human milk induces the expression of the antimicrobial peptide β-defensin in vivo and protects against Salmonella Typhimurium infection of epithelial cells in vitro. In addition, we demonstrated that commercially available 35 kDa size HA induces the expression of β-defensin, upregulates the expression of tight junction protein zonula occludens-1 (ZO-1), and attenuates murine Citrobacter rodentium infection in vivo...
December 1, 2017: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/29262319/citrobacter-rodentium-relies-on-commensals-for-colonization-of-the-colonic-mucosa
#9
Caroline Mullineaux-Sanders, James W Collins, David Ruano-Gallego, Maayan Levy, Meirav Pevsner-Fischer, Izabela T Glegola-Madejska, Agnes M Sågfors, Joshua L C Wong, Eran Elinav, Valerie F Crepin, Gad Frankel
We investigated the role of commensals at the peak of infection with the colonic mouse pathogen Citrobacter rodentium. Bioluminescent and kanamycin (Kan)-resistant C. rodentium persisted avirulently in the cecal lumen of mice continuously treated with Kan. A single Kan treatment was sufficient to displace C. rodentium from the colonic mucosa, a phenomenon not observed following treatment with vancomycin (Van) or metronidazole (Met). Kan, Van, and Met induce distinct dysbiosis, suggesting C. rodentium relies on specific commensals for colonic colonization...
December 19, 2017: Cell Reports
https://www.readbyqxmd.com/read/29248295/nota-analogue-a-first-dithiocarbamate-inhibitor-of-metallo-%C3%AE-lactamases
#10
En Zhang, Ming-Ming Wang, Shu-Chao Huang, Shuai-Min Xu, De-Yun Cui, Yuan-Li Bo, Peng-Yan Bai, Yong-Gang Hua, Chun-Ling Xiao, Shangshang Qin
The emergence of antibiotic drug (like carbapenem) resistance is being a global crisis. Among those resistance factors of the β-lactam antibiotics, the metallo-β-lactamases (MBLs) is one of the most important reasons. In this paper, a series of cyclic dithiocarbamate compounds were synthesized and their inhibition activities against MBLs were initially tested combined with meropenem (MEM) by in vitro antibacterial efficacy tests. Sodium 1,4,7-triazonane-1,4,7-tris(carboxylodithioate) (compound 5) was identified as the most active molecule to restore the activity of MEM...
November 7, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29236574/genetic-diversity-of-kpc-producing-escherichia-coli-klebsiella-oxytoca-serratia-marcescens-and-citrobacter-freundii-isolates-from-argentina
#11
Denise De Belder, Celeste Lucero, Melina Rapoport, Adriana Rosato, Diego Faccone, Alejandro Petroni, Fernando Pasteran, Ezequiel Albornoz, Alejandra Corso, Sonia A Gomez
The predominance of Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae was caused by the spread of ST258 clone. In Latin America, KPC was reported in 2006, with the isolation of genetically unrelated K. pneumoniae in Colombia. Since then, the expansion of blaKPC in either K. pneumoniae ST258 or other Enterobacteriaceae (ETB) species was increasingly reported. In this study, we characterized 89 KPC-producing Escherichia coli, Klebsiella oxytoca, Serratia marcescens, and Citrobacter freundii that were received between 2010 and 2014...
December 13, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29235359/unusual-cranial-infection-caused-by-citrobacter-koseri
#12
Suparna Das, Nicholas Ross
A 60-year-old female had a frontal bone intraosseous meningioma resected 10 years previously. On follow up CT head, an enlarging intraosseous frontal bone lesion was noted. This was thought to be a recurrent frontal meningioma. Intraooperatively, she was found to have an abscess deep to the cranioplasty.
December 13, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29230492/uplc-ms-ms-analysis-of-antibiotics-in-pharmaceutical-effluent-in-tunisia-ecotoxicological-impact-and-multi-resistant-bacteria-dissemination
#13
Leyla Tahrani, Ines Mehri, Tim Reyns, Roel Anthonissen, Luc Verschaeve, Anis Bel Haj Khalifa, Joris Van Loco, Hassen Abdenaceur, Hedi Ben Mansour
The UPLC MS/MS analysis showed the presence of the two antibiotics in the pharmaceutical industry discharges during 3 months; norfloxacin and spiramycin which were quantified with the mean concentrations of 226.7 and 84.2 ng mL-1, respectively. Sixteen resistant isolates were obtained from the pharmaceutical effluent and identified by sequencing. These isolates belong to different genera, namely Citrobacter, Acinetobacter, Pseudomonas, Delftia, Shewanella, and Rheinheimera. The antibiotic resistance phenotypes of these isolates were determined (27 tested antibiotics-discs)...
December 11, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/29230259/-nosocomial-urinary-tract-and-surgical-site-infection-rates-in-the-maternity-ward-at-the-general-referral-hospital-in-katuba-lubumbashi-democratic-republic-of-the-congo
#14
Hendrick Mbutshu Lukuke, Eric Kasamba, Abdulu Mahuridi, Roger Ngatu Nlandu, Suganuma Narufumi, Abel Ntambue Mukengeshayi, Vicky Malou, Michel Makoutode, Françoise Malonga Kaj
Introduction: In Intertropical Africa hospitalized patients are exposed to a risk of nosocomial infections. The dearth of published data on this subject limits the descriptive analysis of the situation. This study aimed to determine the incidence, the germs responsible for these infections and the risk factors of nosocomial infections in the Maternity Ward at the General Referral Hospital in Katuba, Lubumbashi, Democratic Republic of the Congo. Methods: We conducted a descriptive, longitudinal study from 1 October 2014 to 1 January 2015...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29229908/identification-of-regulatory-targets-for-the-bacterial-nus-factor-complex
#15
Gabriele Baniulyte, Navjot Singh, Courtney Benoit, Richard Johnson, Robert Ferguson, Mauricio Paramo, Anne M Stringer, Ashley Scott, Pascal Lapierre, Joseph T Wade
Nus factors are broadly conserved across bacterial species, and are often essential for viability. A complex of five Nus factors (NusB, NusE, NusA, NusG and SuhB) is considered to be a dedicated regulator of ribosomal RNA folding, and has been shown to prevent Rho-dependent transcription termination. Here, we identify an additional cellular function for the Nus factor complex in Escherichia coli: repression of the Nus factor-encoding gene, suhB. This repression occurs primarily by translation inhibition, followed by Rho-dependent transcription termination...
December 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/29228170/biotransformation-of-trinitrotoluene-by-citrobacter-sp-yc4-and-evaluation-of-its-cyto-toxicological-effects
#16
Chih-Ming Kao, Shih-Feng Wei, Ssu Ching Chen, Chao-Ling Yao, Cheng Ma, Chih-Ching Chien
Trinitrotoluene (TNT) is an explosive chemical generally used for military, civil and industrial purposes. Therefore, TNT residue can be found in soil and ground water as an environmental pollutant. The environmental control of TNT pollution has become a critical issue because of its potential toxicity and carcinogenicity. The aim of this study is to evaluate the cyto-toxicological effects of TNT after bioremediation. Citrobacter sp. YC4 is able to utilize TNT as a sole nitrogen source. Citrobacter sp. YC4 cells grown in medium with TNT as the sole nitrogen source (TNT-N) were able to rapidly degrade TNT, in contrast to cells grown in Luria Bertani medium as determined by resting cell suspension...
December 6, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29227180/removal-of-the-cecum-affects-intestinal-fermentation-enteric-bacterial-community-structure-and-acute-colitis-in-mice
#17
Kirsty Brown, D Wade Abbott, Richard R E Uwiera, G Douglas Inglis
The murine cecum is a major site of fermentation of dietary materials, and production of short chain fatty acids (SCFAs). To examine the role that the cecum plays in acute bacterial infection in mice, the cecum was surgically removed, and changes in bacterial communities and production of SCFAs were analyzed relative to surgical sham animals. To incite bacterial colitis, mice were orally challenged with Citrobacter rodentium. The impact of butyrate administered directly into the colon was also examined. Concentrations of SCFAs in feces were substantially lower in mice with an excised cecum...
December 11, 2017: Gut Microbes
https://www.readbyqxmd.com/read/29223516/antimicrobial-activity-of-plazomicin-against-enterobacteriaceae-producing-carbapenemases-from-50-brazilian-medical-centers
#18
Andreza Francisco Martins, Larissa Bail, Carmen Antonia Sanches Ito, Keite da Silva Nogueira, Tanise Vendruscolo Dalmolin, Amanda Silva Martins, Jaime Luis Lopes Rocha, Alisa W Serio, Felipe Francisco Tuon
Plazomicin is a next-generation aminoglycoside with activity against Enterobacteriaceae, including carbapenemase-producing Enterobacteriaceae (CPE). The aim of this study was to evaluate the activity of plazomicin against CPE (Klebsiella spp., Escherichia coli, Serratia spp., Enterobacter spp., Citrobacter spp., Morganella spp., Proteus spp., Providencia spp.) from different Brazilian hospitals. A total of 4000 carbapenem-resistant Enterobacteriaceae isolates were collected from clinical samples in 50 Brazilian hospitals during 2013-2015...
November 10, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29209298/the-gut-entomotype-of-red-palm-weevil-rhynchophorus-ferrugineus-olivier-coleoptera-dryophthoridae-and-their-effect-on-host-nutrition-metabolism
#19
Abrar Muhammad, Ya Fang, Youming Hou, Zhanghong Shi
For invasive insects, the potential roles of gut microbiota in exploiting new food resources and spreading remain elusive. Red palm weevil (RPW), Rhynchophorus ferrugineus Olivier, is an invasive destructive pest which feeds on nutrient-poor tender tissues and has caused extensive mortality of palm trees. The microbes associated with insects can improve their nutrition assimilation. However, experimental evidence on the interactions between RPW and its gut microbiota is still absent. The aim of this study is to determine the dynamics changes and the bacterial entomotype in the RPW gut and its potential physiological roles...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29205415/systematic-review-human-gut-dysbiosis-induced-by-non-antibiotic-prescription-medications
#20
REVIEW
Q Le Bastard, G A Al-Ghalith, M Grégoire, G Chapelet, F Javaudin, E Dailly, E Batard, D Knights, E Montassier
BACKGROUND: Global prescription drug use has been increasing continuously for decades. The gut microbiome, a key contributor to health status, can be altered by prescription drug use, as antibiotics have been repeatedly described to have both short-term and long-standing effects on the intestinal microbiome. AIM: To summarise current findings on non-antibiotic prescription-induced gut microbiome changes, focusing on the most frequently prescribed therapeutic drug categories...
December 5, 2017: Alimentary Pharmacology & Therapeutics
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