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Paul Ansdell, Kevin Thomas, Glyn Howatson, Markus Amann, Stuart Goodall
PURPOSE: To investigate the effects of feedback, in the form of a virtual avatar paced at 100 and 102% of baseline performance, on neuromuscular fatigue following a 4 km cycling time trial (TT). We hypothesised that improved cycling performance would occur due to participants exceeding a previously established critical threshold, and experiencing greater neuromuscular fatigue. METHODS: Following familiarisation, ten well-trained cyclists performed a baseline 4 km TT without feedback (BASE), followed by two, 4 km TT where they raced against an avatar (set at 100% [accurate - ACC] and 102% [deception - DEC] of baseline power output), in a randomised and counterbalanced order...
November 7, 2017: Medicine and Science in Sports and Exercise
Jerrod J Harrison, Marissa K Yorgey, Alexander J Csiernik, Joseph H Vogler, Kenneth E Games
Reference:  Hegedus EJ, McDonough S, Bleakley C, Cook CE, Baxter GD. Clinician-friendly lower extremity physical performance measures in athletes: a systematic review of measurement properties and correlation with injury. Part 1: the tests for knee function including the hop tests. Br J Sports Med. 2015;49(10):642-648. CLINICAL QUESTION:   Do individual physical performance tests (PPTs) used as measures for lower extremity function have any relationship to injuries in athletes aged 12 years or older? DATA SOURCES:   Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used to locate articles...
November 8, 2017: Journal of Athletic Training
M M Delgado-Povedano, M Calderón-Santiago, M D Luque de Castro, F Priego-Capote
Sweat is a promising biofluid scarcely used in clinical analysis despite its non-invasive sampling. A more frequent clinical use of sweat requires to know its whole composition, especially concerning to non-polar compounds, and the development of analytical strategies for its characterization. The aim of the present study was to compare different sample preparation strategies to maximize the detection of metabolites in sweat from humans collected after practicing moderate exercise. Special emphasis was put on non-polar compounds as they have received scant attention in previous studies dealing with this biofluid...
January 15, 2018: Talanta
Suhaj Abdulsalim, Mazhuvancherry Kesavan Unnikrishnan, Mohan K Manu, Alian A Alrasheedy, Brian Godman, Donald E Morisky
BACKGROUND: COPD is characterised by a progressive airflow limitation in the lungs. However, adherence to therapy improves management of symptoms and delays disease progression. Therefore, patients' knowledge and awareness about the disease are important. Hence, pharmacist-led educational interventions could achieve this and improve medication adherence. OBJECTIVE: This study evaluated the effectiveness of a clinical pharmacist-led intervention on medication adherence in COPD patients in a teaching hospital...
October 26, 2017: Research in Social & Administrative Pharmacy: RSAP
Yelena Tonoyan, Theerasak Chanwimalueang, Danilo P Mandic, Marc M Van Hulle
A data-adaptive, multiscale version of Rényi's quadratic entropy (RQE) is introduced for emotional state discrimination from EEG recordings. The algorithm is applied to scalp EEG recordings of 30 participants watching 4 emotionally-charged video clips taken from a validated public database. Krippendorff's inter-rater statistic reveals that multiscale RQE of the mid-frontal scalp electrodes best discriminates between five emotional states. Multiscale RQE is also applied to joint scalp EEG, amygdala- and occipital pole intracranial recordings of an implanted patient watching a neutral and an emotionally charged video clip...
2017: PloS One
Adriano Rodrigues de Oliveira, Adriane Aver Vanin, Shaiane Silva Tomazoni, Eduardo Foschini Miranda, Gianna Móes Albuquerque-Pontes, Thiago De Marchi, Vanessa Dos Santos Grandinetti, Paulo Roberto Vicente de Paiva, Treice Beatriz Gonçalves Imperatori, Paulo de Tarso Camillo de Carvalho, Jan Magnus Bjordal, Ernesto Cesar Pinto Leal-Junior
BACKGROUND: Photobiomodulation therapy (PBMT) has recently been used to alleviate postexercise muscle fatigue and enhance recovery, demonstrating positive results. A previous study by our research group demonstrated the optimal dose for an infrared wavelength (810 nm), but the outcomes could be optimized further with the determination of the optimal output power. OBJECTIVE: The aim of the present study was to evaluate the effects of PBMT (through low-level laser therapy) on postexercise skeletal muscle recovery and identify the best output power...
November 2017: Photomedicine and Laser Surgery
Dibbyan Mazumder, Gurudas Kar, Ram Mohan Vasu, Debasish Roy, Rajan Kanhirodan
We obtain vibro-acoustic (VA) spectral signatures of a remotely palpated region in tissue or tissue-like objects through diffusing-wave spectroscopy (DWS) measurements. Remote application of force is through focused ultrasound, and the spectral signatures correspond to vibrational modes of the focal volume (also called the ROI) excited through ultrasound forcing. In DWS, one recovers the time evolution of mean-square displacement (MSD) of Brownian particles from the measured decay of intensity autocorrelation of light, adapted also to local particles pertaining only to the ROI...
November 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
Michael J Wheeler, Paddy C Dempsey, Megan S Grace, Kathryn A Ellis, Paul A Gardiner, Daniel J Green, David W Dunstan
Cognitive decline leading to dementia represents a global health burden. In the absence of targeted pharmacotherapy, lifestyle approaches remain the best option for slowing the onset of dementia. However, older adults spend very little time doing moderate to vigorous exercise and spend a majority of time in sedentary behavior. Sedentary behavior has been linked to poor glycemic control and increased risk of all-cause mortality. Here, we explore a potential link between sedentary behavior and brain health. We highlight the role of glycemic control in maintaining brain function and suggest that reducing and replacing sedentary behavior with intermittent light-intensity physical activity may protect against cognitive decline by reducing glycemic variability...
September 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
Nabeel P M, Jayaraj Joseph, Mohanasankar Sivaprakasam
<i>Objective:</i> A novel photoplethysmograph (PPG) probe employs dual photodiodes excited using single infrared light source was developed for local Pulse Wave Velocity (PWV) measurement. The potential use of proposed system in cuffless Blood Pressure (BP) techniques was demonstrated. <i>Approach:</i> Initial validation measurements were performed on a phantom using a reference method. Further, an in-vivo study was carried out in 35 volunteers (age = 28 ± 4.5 years). Carotid local PWV, carotid to finger Pulse Transit Time (PTT<sub>R</sub>) and Pulse Arrival Time at the carotid artery (PAT<sub>C</sub>) were simultaneously measured...
October 23, 2017: Physiological Measurement
H K Knych, A Vale, W D Wilson, P H Kass, R M Arthur, J H Jones
Furosemide is a diuretic agent used commonly in racehorses to attenuate the bleeding associated with exercise-induced pulmonary hemorrhage (EIPH). The current study describes serum and urine concentrations and the pharmacokinetics of furosemide following administration at 4 and 24 hrs prior to maximal exercise. Eight exercised adult Thoroughbred horses received a single IV administration of 250 mg of furosemide at 4 and 24 hrs prior to maximal exercise on a high-speed treadmill. Blood and urine samples were collected at time 0 and at various times for up to 72 hrs and furosemide concentrations determined using liquid chromatography-tandem mass spectrometry...
October 22, 2017: Journal of Veterinary Pharmacology and Therapeutics
S Y A Cheung, T Rodgers, L Aarons, I Gueorguieva, G L Dickinson, S Murby, C Brown, B Collins, M Rowland
BACKGROUND AND PURPOSE: Whole body physiologically based pharmacokinetic (PBPK) models have been increasingly applied in drug development to describe kinetic events of therapeutic agents in animals and human. The advantage of such modelling is the ability to incorporate vast amounts of physiological information, such as organ blood flow and volume, to ensure that the model is as close to reality as possible. EXPERIMENTAL APPROACH: Prior PBPK model development of enantiomers of a series of seven racemic betablockers, namely acebutolol, betaxolol, bisoprolol, metoprolol, oxprenolol, pindolol and propranolol, together with S-timolol in rat was based on tissue and blood concentration data at steady state...
October 20, 2017: British Journal of Pharmacology
Artan Ahmeti, Michael Y Henein, Pranvera Ibrahimi, Shpend Elezi, Edmond Haliti, Afrim Poniku, Arlind Batalli, Gani Bajraktari
BACKGROUND: The Minnesota Living with Heart Failure Questionnaire (MLHFQ) is the most widely used measure of quality of life (QoL) in HF patients. This prospective study aimed to assess the relationship between QoL and exercise capacity in HF patients. METHODS: The study subjects were 118 consecutive patients with chronic HF (62 ± 10 years, 57 females, in NYHA I-III). Patients answered a MLHFQ questionnaire in the same day of complete clinical, biochemical and echocardiographic assessment...
October 17, 2017: BMC Cardiovascular Disorders
Jason C Bartram, Dominic Thewlis, David T Martin, Kevin I Norton
PURPOSE: With knowledge of an individual's critical power (CP) and W' the SKIBA 2 model provides a framework with which to track W' balance during intermittent high intensity work bouts. There are fears the time constant controlling the recovery rate of W' (τW') may require refinement to enable effective use in an elite population. METHODS: Four elite endurance cyclists completed an array of intermittent exercise protocols to volitional exhaustion. Each protocol lasted approximately 3...
October 16, 2017: International Journal of Sports Physiology and Performance
Keding Cheng, Angela Sloan, Brooks Waitt, Robert Vendramelli, Debra Godal, Sharon L R Simon, Joe O'Neil, Michael Carpenter, Dave Jackson, Jane Eastlake, Gary Mallinson, J David Knox
BACKGROUND: Bacterially-produced recombinant prion protein (rPrP) has traditionally been used for in vitro fibrillation assays and reagent development for prion disease research. In recent years, it has also been used as a substrate for real-time quaking-induced conversion (RT-QuIC), a very sensitive method of detecting the presence of the misfolded, disease-associated isoform of the prion protein (PrP(d)). Multi-centre trials have demonstrated that RT-QuIC is a suitably reliable and robust technique for clinical practice; however, in the absence of a commercial supplier of rPrP as a substrate for RT-QuIC, laboratories have been required to independently generate this key component of the assay...
October 12, 2017: Protein Expression and Purification
Paige van der Pligt, Kylie Ball, Kylie D Hesketh, David Crawford, Megan Teychenne, Karen Campbell
BACKGROUND: maternal postpartum weight retention (PPWR) has implications for short and long term weight-related health of both the mother and child. Little is known about how mothers perceive they may be best supported to achieve a healthy postpartum weight and healthy lifestyle behaviours. Evaluating existing postpartum weight focussed intervention strategies is an important step in the planning of future programs aimed at supporting new mothers. AIM: to describe the perspectives of women who completed the mums OnLiNE pilot intervention, regarding the acceptability and effectiveness of a program which aimed to limit PPWR and promote healthy diet and physical activity behaviours in new mothers...
September 21, 2017: Midwifery
Mark Hamer, Gary O'Donovan, Marie Murphy
Leisure time physical activity, or exercise, has been described as today's best buy in public health. Physical inactivity is responsible for around 10% of all deaths and physical inactivity costs global healthcare systems billions of dollars each year. Here, we describe the human and economic costs of cardiovascular disease. Then, we explain that physical inactivity is a major modifiable risk factor for cardiovascular disease. The evidence of the role of physical activity in the primary prevention of cardiovascular disease is reviewed and we make the case that exercise is medicine...
2017: Advances in Experimental Medicine and Biology
Dominique Servant, Anne-Claire Leterme, Olivia Barasino, Laure Rougegrez, Alain Duhamel, Guillaume Vaiva
BACKGROUND: Adjustment disorder with anxiety (ADA) is the most frequent and best characterized stress-related psychiatric disorder. The rationale for prescription of benzodiazepine monotherapy is a public health issue. Cognitive behavioral stress management programs have been studied in many countries. Several reports have shown beyond reasonable doubt their efficiency at reducing perceived stress and anxiety symptoms and improving patient quality of life. Considering the number of people who could benefit from such programs but are unable to access them, self-help programs have been offered...
October 2, 2017: JMIR Research Protocols
Fiona Ulph, Stuart Wright, Nimarta Dharni, Katherine Payne, Rebecca Bennett, Stephen Roberts, Kieran Walshe, Tina Lavender
BACKGROUND: Participation in the UK Newborn Bloodspot Screening Programme (NBSP) requires parental consent but concerns exist about whether or not this happens in practice and the best methods and timing to obtain consent at reasonable cost. OBJECTIVES: To collate all possible modes of prescreening communication and consent for newborn (neonatal) screening (NBS); examine midwives', screening professionals' and users' views about the feasibility, efficiency and impact on understanding of each; measure midwives' and parents' preferences for information provision; and identify key drivers of cost-effectiveness for alternative modes of information provision...
October 2017: Health Technology Assessment: HTA
Cody E Morris, John C Garner, Scott G Owens, Melinda W Valliant, Hunter Debusk, Mark Loftin
Prior work has reported that the declines observed in body mass index (BMI) and circumference measurements in their cross-sectional data were twice as large when calculated from distance energy expenditure estimations compared to energy expenditure estimations based on time and intensity. The primary purpose of this study was to compare walking/running for distance to walking/running for time as part of an exercise intervention. This study followed a between-subjects, repeated measures design. Fifteen overweight, but otherwise healthy participants completed the study...
2017: International Journal of Exercise Science
Jarad S Miller, Donna J Terbizan
This study examined the effects of stimulating and sedative music on ratings of perceived exertion (RPE), heart rate (HR), blood pressure (BP), and feeling status during exercise in cardiac rehabilitation (CR) patients. Twenty-two male and female older adults age 64 ± 8.0 y currently enrolled in phase III CR completed the study. Repeated measures crossover designs guided data collection. The manipulated independent variable was music condition (sedative, stimulating, and non-music control). The dependent variables were RPE, BP, HR, and feeling status with each represented by four repeated measures ANOVAs over time via SAS 9...
2017: International Journal of Exercise Science
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