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Paediatric malignancy

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https://www.readbyqxmd.com/read/29906523/ventricular-fibromas-in-children-arrhythmia-risk-and-outcomes-a-multicentre-study
#1
John P Jones, Tristan Ramcharan, Milind Chaudhari, Vinay Bhole, Karen Mcleod, Shankar Sadagopan, Orhan Uzun, Andrew Parry, Jan Till, Colin J McMahon, Alan G Stuart, Mark A Walsh
BACKGROUND: Although ventricular fibromas are a rare, they are the second most common type of cardiac tumor in children. While histologically benign, they have a propensity to cause malignant arrhythmias, with cardiac arrest often being the first presentation.; OBJECTIVE: To evaluate the arrhythmia risk, and management strategies for pediatric ventricular fibromas. METHODS: Fifteen centers in the British Paediatric Arrhythmia Group network were contacted to partake in the study to contribute cases...
June 12, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29902672/childhood-cancer-registration-in-new-zealand-a-registry-collaboration-to-asssess-and-improve-data-quality
#2
Kirsten R Ballantine, Susan Hanna, Scott Macfarlane, Peter Bradbeer, Lochie Teague, Sarah Hunter, Siobhan Cross, Jane Skeen
AIM: To evaluate the completeness and accuracy of child cancer registration in New Zealand. METHODS: Registrations for children aged 0-14 diagnosed between 1/1/2010 and 31/12/2014 were obtained from the New Zealand Cancer Registry (NZCR) and the New Zealand Children's Cancer Registry (NZCCR). Six key data fields were matched using National Health Index numbers in order to identify and resolve registration discrepancies. Capture-recapture methods were used to assess the completeness of cancer registration...
June 11, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29875926/-acute-lymphoblastic-leukemia-among-children-in-ouagadougou-burkina-faso-the-results-of-treatment-according-to-the-protocol-of-the-franco-african-pediatric-oncology-group-2005
#3
Sonia Douamba, Fatimata Diallo, Kisito Nagalo, Laure Tamini, Lassina Dao, Fla Kouéta, Diarra Yé
Introduction: acute lymphoblastic leukemia (ALL) is being diagnosed in an increasing number of children in our Department. In the developed countries, the treatment of this hematologic malignancy can cure almost 80% of children. In developing countries, few studies focus on acute leukemias in children. The results of cancer treatments in children are disappointing in most African countries, with a survival rate of 10-15%. This study aimed to investigate the clinical, biological, therapeutic and evolutionary features of ALL in children...
2018: Pan African Medical Journal
https://www.readbyqxmd.com/read/29863780/early-central-line-associated-blood-stream-infections-in-children-with-cancer-pose-a-risk-for-premature-catheter-removal
#4
Jacob Moell, Anna Svenningsson, Margareta Af Sandeberg, Magnus Larsson, Mats Heyman, Arja Harila-Saari, Anna Nilsson
AIM: This study examined the clinical characteristics of central line associated blood stream infections occurring within 30 days after insertion versus later infections in paediatric cancer patients, and the subsequent risk for premature catheter removal. METHODS: This was a retrospective study of children aged 0-18 years who were diagnosed with cancer from 2013-2014 at the Astrid Lindgren Children Hospital, Sweden. Clinical and microbiology data for each patient was collected for 365 days after the central venous catheter was inserted...
June 4, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29862079/the-burden-and-outcomes-of-abdominal-pain-among-children-presenting-to-an-emergency-department-of-a-tertiary-hospital-in-tanzania-a-descriptive-cohort-study
#5
Francis M Sakita, Hendry R Sawe, Victor Mwafongo, Juma A Mfinanga, Michael S Runyon, Brittany L Murray
Background: Abdominal pain in children can represent benign conditions or life-threatening emergencies. Aetiologies of paediatric abdominal pain vary geographically and have not been studied in acute care settings in East Africa. This study describes the clinical profiles and outcomes of children presenting with undifferentiated abdominal pain to the Emergency Department of Muhimbili National Hospital (ED-MNH). Methods: This was a prospective cohort study of children below 18 years of age presenting to the ED-MNH with abdominal pain...
2018: Emergency Medicine International
https://www.readbyqxmd.com/read/29859588/is-tonsillectomy-mandatory-for-asymmetric-tonsils-in-children-a-review-of-our-diagnostic-tonsillectomy-practice-and-the-literature
#6
Gareth Huw Jones, Girvan Burnside, Jo McPartland, Anne Markey, Michael Fallon, Sujata De
INTRODUCTION: Diagnostic tonsillectomy is performed to exclude malignancy. It is associated with a post-operative hemorrhage rate of 3.5%, (1) which is more dangerous in small children. No previous case series for asymmetrical tonsils have detected tonsil lymphoma.(2-6) We aimed to review our local diagnostic tonsillectomy practice. METHOD: The authors reviewed the clinical notes and histological results for all diagnostic tonsillectomies carried out from June 2013 to June 2016...
July 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29859339/comparison-of-carboplatin-versus-cisplatin-in-the-treatment-of-paediatric-extracranial-malignant-germ-cell-tumours-a-report-of-the-malignant-germ-cell-international-consortium
#7
A Lindsay Frazier, Sara Stoneham, Carlos Rodriguez-Galindo, Ha Dang, Caihong Xia, Thomas A Olson, Matthew J Murray, James F Amatruda, Furqan Shaikh, Farzana Pashankar, Deborah Billmire, Mark Krailo, Dan Stark, Mark F H Brougham, James C Nicholson, Juliet P Hale
PURPOSE: To compare the outcomes of paediatric and adolescent extracranial malignant germ cell tumour (GCT) patients treated with either carboplatin or cisplatin on clinical trials conducted by the Children's Oncology Group (COG) and the Children's Cancer and Leukaemia Group (CCLG). METHODS: The Malignant Germ Cell International Consortium (MaGIC) has created a database of the GCT clinical trials conducted since 1983 by COG (United States, Canada and Australia), which used cisplatin-based regimens, and by CCLG (United Kingdom), which used carboplatin-based regimens...
May 30, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29850551/serum-s100b-levels-can-predict-computed-tomography-findings-in-paediatric-patients-with-mild-head-injury
#8
Fatos M Kelmendi, Arsim A Morina, Agon Y Mekaj, Afrim Blyta, Ridvan Alimehmeti, Shefki Dragusha, Feti Ahmeti, Qamile Morina, Afrim Kotori
Introduction: Traumatic brain injuries (TBIs) are very common in paediatric populations, in which they are also a leading cause of death. Computed tomography (CT) overuse in these populations results in ionization radiation exposure, which can lead to lethal malignancies. The aims of this study were to investigate the accuracy of serum S100B levels with respect to the detection of cranial injury in children with mild TBI and to determine whether decisions regarding the performance of CT can be made based on biomarker levels alone...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29767474/mesenchymal-stromal-cells-from-shwachman-diamond-syndrome-patients-fail-to-recreate-a-bone-marrow-niche-in-vivo-and-exhibit-impaired-angiogenesis
#9
Donatella Bardelli, Erica Dander, Cristina Bugarin, Claudia Cappuzzello, Alice Pievani, Grazia Fazio, Paolo Pierani, Paola Corti, Piero Farruggia, Carlo Dufour, Simone Cesaro, Marco Cipolli, Andrea Biondi, Giovanna D'Amico
Shwachman-Diamond syndrome (SDS) is a rare multi-organ recessive disease mainly characterised by pancreatic insufficiency, skeletal defects, short stature and bone marrow failure (BMF). As in many other BMF syndromes, SDS patients are predisposed to develop a number of haematopoietic malignancies, particularly myelodysplastic syndrome and acute myeloid leukaemia. However, the mechanism of cancer predisposition in SDS patients is only partially understood. In light of the emerging role of mesenchymal stromal cells (MSCs) in the regulation of bone marrow homeostasis, we assessed the ability of MSCs derived from SDS patients (SDS-MSCs) to recreate a functional bone marrow niche, taking advantage of a murine heterotopic MSC transplant model...
May 16, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29751600/inflamed-phylloides-tumour-in-a-girl-a-challenging-diagnosis-in-paediatric-breast-lesions
#10
Ilaria Testa, Cristina Salvatori, Marco Prestipino, Maria Elena Laurenti, Paolo Gerli, Giuseppe Di Cara, Nicola Principi, Susanna Esposito, Mirko Bertozzi
Introduction : Phylloides tumours (PTs) are rare fibroepithelial neoplasms that account for 0.3⁻0.9% of all breast tumours. These tumours typically occur in women aged 30⁻70 years. The occurrence of these tumours in older children and adolescents poses particular diagnostic and therapeutic problems. However, early diagnosis is mandatory because although most of the cases of PTs in children are benign, the borderline and malignant cases with potential negative outcomes cannot be excluded. Case presentation : A 12-year-old girl presented at the Paediatric Emergency Department for hyperaemia and warmth of the left breast that occurred a few days prior without fever...
May 11, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29723241/intra-operative-cerebrospinal-fluid-sampling-versus-post-operative-lumbar-puncture-for-detection-of-leptomeningeal-disease-in-malignant-paediatric-brain-tumours
#11
Sharon Y Y Low, Chen Min Wei, Kenneth T E Chang, Chan Yiong Huak, Ng Lee Ping, Seow Wan Tew, David C Y Low
INTRODUCTION: Leptomeningeal disease is a feared sequelae of malignant paediatric brain tumours. Current methods for its detection is the combined use of cranio-spinal MRI, and CSF cytology from a post-operative lumbar puncture. In this study, the authors hypothesize that CSF taken at the start of surgery, either from an external ventricular drain or neuroendoscope will have equal sensitivity for positive tumour cells, in comparison to lumbar puncture. Secondary hypotheses include positive correlation between CSF cytology and MRI findings of LMD...
2018: PloS One
https://www.readbyqxmd.com/read/29716399/informed-consent-in-pediatric-oncology-a-systematic-review-of-qualitative-literature
#12
Ghiath Alahmad
OBJECTIVE: Obtaining informed consent in pediatric cancer research can be subject to important ethical challenges because of the difficulty in distinguishing between care and research, which are interrelated. Pediatric oncologists also often conduct research, such as clinical trials, on their own patients, which may influence voluntary informed consent. This review aims to determine the ethical issues encountered in obtaining informed consent in pediatric oncology by identifying and summarizing the findings of existing qualitative studies on this topic...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/29701240/a-10-year-longitudinal-follow-up-study-of-a-uk-paediatric-transplant-population-to-assess-for-skin-cancer
#13
S H Foo, P G Nightingale, P Gazzani, E Bader, M Ogboli, A Martin-Clavijo, D V Milford, D A Kelly, C Moss, M A Thomson
BACKGROUND: Our earlier study published in 2004 1 found no skin cancer in a cohort of paediatric organ transplant recipients (POTRs) 5 to 16 years post-transplantation. We re-evaluated the same cohort 10 years later. OBJECTIVES: To determine the prevalence of premalignant and malignant skin lesions and identify known risk factors associated with melanocytic naevi in a UK paediatric transplant population. METHODS: Ninety eight POTRs from the original 2004 study were invited to participate in this longitudinal follow-up study...
April 27, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29699707/anaesthetic-management-of-a-paediatric-patient-with-congenital-fibre-type-disproportion-myopathy
#14
F Buisán, O de la Varga, M Flores, J Sánchez-Ruano
Congenital fibre type disproportion (CFTD) is a rare type of myopathy that is characterised by muscle weakness and hypotonia during childhood. Clinical features include motor delay, feeding difficulties, limb weakness, joint contractures, and scoliosis. A report is presented of the anaesthetic management of a 3-year-old girl with CFTD myopathy associated with a mutation of the TPM3 gene, scheduled for adenotonsillectomy because of obstructive sleep apnoea hypopnoea syndrome (OSAHS). The main concerns were the possible susceptibility to malignant hyperthermia, the risk of anaesthesia-induced rhabdomyolysis, a greater sensitivity to non-depolarising muscle relaxants, and the presence of OSAHS...
April 23, 2018: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/29697190/treatment-of-retinoblastoma-in-sub-saharan-africa-experience-of-the-paediatric-oncology-unit-at-gabriel-toure-teaching-hospital-and-the-institute-of-african-tropical-ophthalmology-bamako-mali
#15
Fousseyni Traoré, Fatou Sylla, Boubacar Togo, Bakarou Kamaté, Konimba Diabaté, Abdoul Aziz Diakité, Hawa Diall, Fatoumata Dicko, Mariam Sylla, Pierre Bey, Laurence Desjardins, Anne Gagnepain-Lacheteau, Carole Coze, Mhamed Harif, François Doz
BACKGROUND: Retinoblastoma (Rb) is the most common intraocular primary malignancy in children. In industrialised countries, the cure rate is about 95%. We present the results of a prospective study on the management of Rb in the paediatric oncology unit of Gabriel Touré Teaching Hospital and African Institute of Tropical Ophthalmology, from November 1, 2011 to December 31, 2015. PROCEDURE: The aims of this prospective study were to evaluate the treatment of localised Rb, ocular prosthesis after enucleation, conservative management for bilateral Rb as well as survival rates in all patients...
April 26, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29680797/xp11-translocation-renal-cell-carcinoma-paraneoplastic-syndrome-presenting-as-cutaneous-vasculitis-first-reported-case-of-yet-another-mask
#16
Claire Pascoe, Daniel Christidis, David Clouston, Nathan Lawrentschuk
Renal cell carcinoma is historically known as the 'great masquerader' with 40% of patients experiencing a paraneoplastic syndrome. Translocation carcinoma represents one-third of renal cancer in paediatric patients but less than 3% of renal cancers in patients aged 18-45 years where the clinical course is often rapidly terminal. There are less than 10 reported cases of leucoclastic vasculitis associated with clear cell carcinoma reported in the literature and 10 case reports of translocation carcinoma in adults...
April 21, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29672904/growth-hormone-insulin-like-growth-factor-1-axis-hyperactivity-on-bone-fibrous-dysplasia-in-mccune-albright-syndrome
#17
Daniele Tessaris, Alison M Boyce, Margaret Zacharin, Patrizia Matarazzo, Roberto Lala, Luisa De Sanctis, Michael T Collins
CONTEXT: In fibrous dysplasia (BFD), normal bone and bone marrow are replaced by fibro-osseous tissue, leading to fracture, deformity and pain. BFD may be isolated, or in association with cutaneous hyperpigmentation and/or hyperfunctioning endocrinopathies, termed McCune-Albright syndrome (MAS). GH hypersecretion has been described in 10%-20% of MAS-BFD patients. Aim of the study was to determine the impact of GH-insulin like growth factor 1 (IGF1) axis hyperactivity on MAS-BFD morbidities and the efficacy of GH excess therapy...
April 19, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29666178/causes-of-death-in-a-contemporary-adult-congenital-heart-disease-cohort
#18
Christopher Yu, Benjamin M Moore, Irina Kotchetkova, Rachael L Cordina, David S Celermajer
OBJECTIVE: The life expectancy of patients with congenital heart disease (CHD) has significantly improved with advances in their paediatric medical care. Mortality patterns are changing as a result. Our study aims to describe survival and causes of death in a contemporary cohort of adult patients with CHD. METHODS: We reviewed 3068 patients in our adult CHD database (age ≥16 years, seen at least once in our centre between 2000 and 2015), and documented the number and causes of death, via Australia's National Death Index...
April 17, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29623582/childhood-and-adolescent-lymphoma-in-spain-incidence-and-survival-trends-over-20-years
#19
R Marcos-Gragera, M Solans, J Galceran, R Fernández-Delgado, A Fernández-Teijeiro, A Mateos, J R Quirós-Garcia, N Fuster-Camarena, V De Castro, M J Sánchez, P Franch, M D Chirlaque, E Ardanaz, C Martos, D Salmerón, R Peris-Bonet
BACKGROUND: Lymphoma is the third most common malignancy in children (0-14 years) and the first in adolescents (15-19 years). This population-based study-the largest ever done in Spain-analyses incidence and survival of lymphomas among Spanish children and adolescents. PATIENTS AND METHODS: 1664 lymphoma cases (1983-2007) for incidence and 1030 for survival (1991-2005) followed until 31/12/2010, were provided by 11 cancer registries. Age-adjusted incidence rates (ASRw) to the world standard population were obtained; incidence trends were modelled using the Joinpoint programme, observed survival (OS) was estimated with Kaplan-Meier and trends tested with a log-rank test...
April 5, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29606586/larotrectinib-for-paediatric-solid-tumours-harbouring-ntrk-gene-fusions-phase-1-results-from-a-multicentre-open-label-phase-1-2-study
#20
Theodore W Laetsch, Steven G DuBois, Leo Mascarenhas, Brian Turpin, Noah Federman, Catherine M Albert, Ramamoorthy Nagasubramanian, Jessica L Davis, Erin Rudzinski, Angela M Feraco, Brian B Tuch, Kevin T Ebata, Mark Reynolds, Steven Smith, Scott Cruickshank, Michael C Cox, Alberto S Pappo, Douglas S Hawkins
BACKGROUND: Gene fusions involving NTRK1, NTRK2, or NTRK3 (TRK fusions) are found in a broad range of paediatric and adult malignancies. Larotrectinib, a highly selective small-molecule inhibitor of the TRK kinases, had shown activity in preclinical models and in adults with tumours harbouring TRK fusions. This study aimed to assess the safety of larotrectinib in paediatric patients. METHODS: This multicentre, open-label, phase 1/2 study was done at eight sites in the USA and enrolled infants, children, and adolescents aged 1 month to 21 years with locally advanced or metastatic solid tumours or CNS tumours that had relapsed, progressed, or were non-responsive to available therapies regardless of TRK fusion status; had a Karnofsky (≥16 years of age) or Lansky (<16 years of age) performance status score of 50 or more, adequate organ function, and full recovery from the acute toxic effects of all previous anticancer therapy...
May 2018: Lancet Oncology
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