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https://www.readbyqxmd.com/read/29778509/longitudinal-observations-using-simultaneous-fmri-multiple-channel-electrophysiology-recording-and-chemical-microiontophoresis-in-the-rat-brain
#1
Saul Jaime, Jose E Cavazos, Yihong Yang, Hanbing Lu
BACKGROUND: fMRI blood oxygenation level-dependent (BOLD) signal has been widely used as a surrogate for neural activity. However, interpreting differences in BOLD fMRI based on underlying neuronal activity remains a challenge. Concurrent rsMRI data collection and electrophysiological recording in combination with microiontophoretically injected modulatory chemicals allows for improved understanding of the relationship between resting state BOLD and neuronal activity. NEW METHODS: Simultaneous fMRI, multi-channel intracortical electrophysiology and focal pharmacological manipulation data to be acquired longitudinally in rats for up to 2 months...
May 17, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29777890/cortical-activation-changes-in-hirayama-disease-following-anterior-cervical-decompression-and-fusion
#2
Hongli Wang, Yiwei Wu, Jian Song, Jianyuan Jiang, Feizhou Lu, Xiaosheng Ma, Xinlei Xia
BACKGROUND: Spinal cord injury may cause cortical reconstruction. We, therefore, explored thechanges in cortical activation before and after anterior cervical decompression and fusion surgery in patients with Hirayama disease (HD). METHODS: 17 HD cases were performed anterior cervical decompression and fusion surgery. BOLD-fMRI scan was performed preoperatively, 3 months, 6 months and 1 year after surgery. Activated voxels were compared between both hands after adjusting for head motion, slice timing, spatial normalization and image smoothing...
May 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29777828/mutual-connectivity-analysis-of-resting-state-functional-mri-data-with-local-models
#3
Adora M DSouza, Anas Z Abidin, Udaysankar Chockanathan, Giovanni Schifitto, Axel Wismüller
Functional connectivity analysis of functional MRI (fMRI) can represent brain networks and reveal insights into interactions amongst different brain regions. However, most connectivity analysis approaches adopted in practice are linear and non-directional. In this paper, we demonstrate the advantage of a data-driven, directed connectivity analysis approach called Mutual Connectivity Analysis using Local Models (MCA-LM) that approximates connectivity by modeling nonlinear dependencies of signal interaction, over more conventionally used approaches, such as Pearson's and partial correlation, Patel's conditional dependence measures, etcetera...
May 16, 2018: NeuroImage
https://www.readbyqxmd.com/read/29777824/brain-network-segregation-and-integration-during-an-epoch-related-working-memory-fmri-experiment
#4
Peter Fransson, Björn C Schiffler, William Hedley Thompson
The characterization of brain subnetwork segregation and integration has previously focused on changes that are detectable at the level of entire sessions or epochs of imaging data. In this study, we applied time-varying functional connectivity analysis together with temporal network theory to calculate point-by-point estimates in subnetwork segregation and integration during an epoch-based (2-back, 0-back, baseline) working memory fMRI experiment as well as during resting-state. This approach allowed us to follow task-related changes in subnetwork segregation and integration at a high temporal resolution...
May 16, 2018: NeuroImage
https://www.readbyqxmd.com/read/29774625/effect-of-phase-encoding-direction-on-group-analysis-of-resting-state-functional-magnetic-resonance-imaging
#5
Yasuo Mori, Jun Miyata, Masanori Isobe, Shuraku Son, Yujiro Yoshihara, Toshihiko Aso, Takanori Kouchiyama, Toshiya Murai, Hidehiko Takahashi
AIM: Echo-planar imaging is a common technique used in functional magnetic resonance imaging (fMRI), however it suffers from image distortion and signal loss because of large susceptibility effects that are related to the phase-encoding direction of the scan. Despite this relationship, the majority of neuroimaging studies have not considered the influence of phase-encoding direction. Here, we aimed to clarify how phase-encoding direction can affect the outcome of an fMRI connectivity study of schizophrenia...
May 17, 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/29774500/thalamocortical-dysconnectivity-in-premenstrual-syndrome
#6
Peng Liu, Ying Wei, Hai Liao, Yingying Fan, Ru Li, Nana Feng, Gaoxiong Duan, Demao Deng, Wei Qin
Premenstrual syndrome (PMS) is a menstrual cycle-related disorder. Although the precise pathophysiology is not fully understood, it is increasingly believed that the central nervous system plays a vital role in the development of PMS. The aim of this study is to elucidate specific functional connectivity between the thalamus and cerebral cortex. Resting-state functional magnetic resonance imaging (fMRI) data were obtained from 20 PMS patients and 21 healthy controls (HCs). Seed-based functional connectivity between the thalamus and six cortical regions of interest, including the prefrontal cortex (PFC), posterior parietal cortex, somatosensory cortex, motor cortex/supplementary motor area, temporal and occipital lobe, was adopted to identify specific thalamocortical connectivity in the two groups...
May 17, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29774003/disrupted-spontaneous-neural-activity-related-to-cognitive-impairment-in-postpartum-women
#7
Jin-Xia Zheng, Yu-Chen Chen, Huiyou Chen, Liang Jiang, Fan Bo, Yuan Feng, Wen-Wei Tang, Xindao Yin, Jian-Ping Gu
Purpose: Prior research has demonstrated that the postpartum period is associated with an increased risk of cognitive impairment. This study aims to investigate whether disrupted spontaneous neural activity exists in postpartum women without depression using resting-state functional magnetic resonance imaging (rs-fMRI) and to detect the relationship between these abnormalities and cognitive impairment. Materials and Methods: Postpartum women ( n = 22) were compared with age- and education-matched nulliparous women ( n = 23) using rs-fMRI...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29773923/brain-activity-low-self-control-and-delinquency-an-fmri-study-of-at-risk-adolescents
#8
Ryan Charles Meldrum, Elisa M Trucco, Lora M Cope, Robert A Zucker, Mary M Heitzeg
Purpose: A vast literature finds that low self-control is associated with a myriad of antisocial behaviors. Consequently, increasing attention has focused on the causes of low self-control. While criminologists have directed significant attention to studying its social causes, fewer studies have considered its neural bases. Methods: We add to this nascent body of research by using data collected on an at-risk sample of adolescents participating in the ongoing Michigan Longitudinal Study...
May 2018: Journal of Criminal Justice
https://www.readbyqxmd.com/read/29772380/task-dependent-modulation-of-the-visual-sensory-thalamus-assists-visual-speech-recognition
#9
Begoña Díaz, Helen Blank, Katharina von Kriegstein
The cerebral cortex modulates early sensory processing via feed-back connections to sensory pathway nuclei. The functions of this top-down modulation for human behavior are poorly understood. Here, we show that top-down modulation of the visual sensory thalamus (the lateral geniculate body, LGN) is involved in visual-speech recognition. In two independent functional magnetic resonance imaging (fMRI) studies, LGN response increased when participants processed fast-varying features of articulatory movements required for visual-speech recognition, as compared to temporally more stable features required for face identification with the same stimulus material...
May 14, 2018: NeuroImage
https://www.readbyqxmd.com/read/29772378/a-task-invariant-cognitive-reserve-network
#10
Yaakov Stern, Yunglin Gazes, Qolomreza Razlighi, Jason Steffener, Christian Habeck
The concept of cognitive reserve (CR) can explain individual differences in susceptibility to cognitive or functional impairment in the presence of age or disease-related brain changes. Epidemiologic evidence indicates that CR helps maintain performance in the face of pathology across multiple cognitive domains. We therefore tried to identify a single, "task-invariant" CR network that is active during the performance of many disparate tasks. In imaging data acquired from 255 individuals age 20-80 while performing 12 different cognitive tasks, we used an iterative approach to derive a multivariate network that was expressed during the performance of all tasks, and whose degree of expression correlated with IQ, a proxy for CR...
May 14, 2018: NeuroImage
https://www.readbyqxmd.com/read/29771566/the-evil-of-banality-when-choosing-between-the-mundane-feels-like-choosing-between-the-worst
#11
Amitai Shenhav, Carolyn K Dean Wolf, Uma R Karmarkar
Our most important decisions often provoke the greatest anxiety, whether we seek the better of two prizes or the lesser of two evils. Yet many of our choices are more mundane, such as selecting from a slate of mediocre but acceptable restaurants. Previous research suggests that choices of decreasing value should provoke decreasing anxiety. Here we show that this is not the case. Across three behavioral studies and one fMRI study, we find that anxiety and its neural correlates demonstrate a U-shaped function of choice set value, greatest when choosing between both the highest value and lowest value sets...
May 17, 2018: Journal of Experimental Psychology. General
https://www.readbyqxmd.com/read/29771186/cross-modal-plasticity-among-sensory-networks-in-neuromyelitis-optica-spectrum-disorders
#12
Maria Assunta Rocca, Filippo Savoldi, Paola Valsasina, Marta Radaelli, Paolo Preziosa, Giancarlo Comi, Andrea Falini, Massimo Filippi
OBJECTIVE: To explore resting-state (RS) functional connectivity (FC) of the main sensory/motor networks of patients with neuromyelitis optica spectrum disorders (NMOSDs), clinically isolated optic neuritis (ON), and myelitis. METHODS: Clinical evaluation and RS fMRI were obtained from 28 NMOSD, 11 recurrent ON, and 12 recurrent myelitis patients and 30 healthy controls. Between-group RS FC comparisons and correlations with motor performance were assessed (SPM12) on the main sensory/motor RS networks (RSNs) identified by independent component analysis...
May 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29769613/genetic-variant-for-behavioral-regulation-factor-of-executive-function-and-its-possible-brain-mechanism-in-attention-deficit-hyperactivity-disorder
#13
Xiao Sun, Zhaomin Wu, Qingjiu Cao, Ying Qian, Yong Liu, Binrang Yang, Suhua Chang, Li Yang, Yufeng Wang
As a childhood-onset psychiatric disorder, attention deficit hyperactivity disorder (ADHD) is complicated by phenotypic and genetic heterogeneity. Lifelong executive function deficits in ADHD are described in many literatures and have been proposed as endophenotypes of ADHD. However, its genetic basis is still elusive. In this study, we performed a genome-wide association study of executive function, rated with Behavioral Rating Inventory of Executive Function (BRIEF), in ADHD children. We identified one significant variant (rs852004, P = 2...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29767624/the-maternal-brain-in-women-with-a-history-of-early-life-maltreatment-an-imagination-based-fmri-study-of-conflictual-versus-pleasant-interactions-with-children
#14
Corinne Neukel, Katja Bertsch, Anna Fuchs PhD, Anna-Lena Zietlow, Corinna Reck, Eva Moehler, Romuald Brunner, Felix Bermpohl, Sabine C Herpertz
BACKGROUND: Early-life maltreatment has severe consequences for the affected individual, and it has an impact on the next generation. To improve understanding of the intergenerational effects of abuse, we investigated the consequences of early-life maltreatment on maternal sensitivity and associated brain mechanisms during mother-child interactions. METHODS: In total, 47 mothers (22 with a history of physical and/or sexual childhood abuse and 25 without, all without current mental disorders) took part in a standardized real-life interaction with their 7- to 11-year-old child (not abused) and a subsequent functional imaging script-driven imagery task...
May 16, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29767303/the-neural-signatures-of-egocentric-bias-in-normative-decision-making
#15
Chunliang Feng, Xue Feng, Li Wang, Lili Wang, Ruolei Gu, Aiping Ni, Gopikrishna Deshpande, Zhihao Li, Yue-Jia Luo
Bargaining parties often disagree on what fair is, due to the reason that people are prone to believe that what favors oneself is fair, i.e., an egocentric bias. In this study, we investigated the neural signatures underlying egocentric bias in fairness decision-making, conjoining an adapted ultimatum game (UG) with event-related fMRI and functional connectivity. Participants earned monetary rewards with a partner in a production stage, wherein their contributions to the earnings were manipulated. Afterwards, the joint earnings were randomly divided, and the distribution was presented simultaneously with contribution information to participants, who accepted/rejected distributions of earnings as the same manner in standard UG...
May 16, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29766762/typical-visual-field-locations-enhance-processing-in-object-selective-channels-of-human-occipital-cortex
#16
Daniel Kaiser, Radoslaw M Cichy
Natural environments consist of multiple objects, many of which repeatedly occupy similar locations within a scene. For example, hats are seen on people's heads, while shoes are most often seen close to the ground. Such positional regularities bias the distribution of objects across the visual field: Hats are more often encountered in the upper visual field, while shoes are more often encountered in the lower visual field. Here we test the hypothesis that typical visual-field locations of objects facilitate cortical processing...
May 16, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29766355/early-functional-mri-activation-predicts-motor-outcome-after-ischemic-stroke-a-longitudinal-multimodal-study
#17
Juan Du, Fang Yang, Zhiqiang Zhang, Jingze Hu, Qiang Xu, Jianping Hu, Fanyong Zeng, Guangming Lu, Xinfeng Liu
An accurate prediction of long term outcome after stroke is urgently required to provide early individualized neurorehabilitation. This study aimed to examine the added value of early neuroimaging measures and identify the best approaches for predicting motor outcome after stroke. This prospective study involved 34 first-ever ischemic stroke patients (time since stroke: 1-14 days) with upper limb impairment. All patients underwent baseline multimodal assessments that included clinical (age, motor impairment), neurophysiological (motor-evoked potentials, MEP) and neuroimaging (diffusion tensor imaging and motor task-based fMRI) measures, and also underwent reassessment 3 months after stroke...
May 15, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29764028/-application-of-3d-virtual-reality-technology-with-multi-modality-fusion-in-resection-of-glioma-located-in-central-sulcus-region
#18
T N Chen, X T Yin, X G Li, J Zhao, L Wang, N Mu, K Ma, K Huo, D Liu, B Y Gao, H Feng, F Li
Objective: To explore the clinical and teaching application value of virtual reality technology in preoperative planning and intraoperative guide of glioma located in central sulcus region. Method: Ten patients with glioma in the central sulcus region were proposed to surgical treatment. The neuro-imaging data, including CT, CTA, DSA, MRI, fMRI were input to 3dgo sczhry workstation for image fusion and 3D reconstruction. Spatial relationships between the lesions and the surrounding structures on the virtual reality image were obtained...
May 8, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29763448/modulation-of-functional-activity-and-connectivity-by-acupuncture-in-patients-with-alzheimer-disease-as-measured-by-resting-state-fmri
#19
Weimin Zheng, Zhuangzhi Su, Xingyun Liu, Hao Zhang, Ying Han, Haiqing Song, Jie Lu, Kuncheng Li, Zhiqun Wang
Acupuncture has been used in the therapy of Alzheimer disease (AD); however, its neural mechanisms are still unclear. The aim of this study is to examine the effect of acupuncture on the functional connectivity in AD by using resting-state functional magnetic resonance imaging (rs-fMRI). Twenty-eight subjects (14 AD and 14 normal controls) participated in this study. The rs-fMRI data were acquired before and after acupuncture stimulation at the acupoints of Tai chong (Liv3) and Hegu (LI4). During the baseline resting state, by using the amplitude of low-frequency fluctuations (ALFF), we found a significantly decreased or increased ALFF in the AD patients relative to the controls...
2018: PloS One
https://www.readbyqxmd.com/read/29761998/functional-magnetic-resonance-imaging-in-glioma-patients-from-clinical-applications-to-future-perspectives
#20
Lukas J Volz, Martin Kocher, Philipp Lohmann, Nadim J Shah, Gereon R Fink, Norbert Galldiks
Functional magnetic resonance imaging (fMRI) allows the non-invasive assessment of human brain activity in-vivo. In glioma patients, fMRI is frequently used to determine the individual functional anatomy of the motor and language network in a pre-surgical setting to optimize surgical procedures and prevent extensive damage to functionally eloquent areas. Novel developments based on resting- state fMRI may help to improve pre-surgical planning for patients which are unable to perform structured tasks and might extend pre-surgical mapping to include additional functional networks...
May 14, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
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