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https://www.readbyqxmd.com/read/28730947/safety-of-nitric-oxide-added-to-the-ecmo-circuit-a-pilot-study-in-children
#1
Roberto Chiletti, Steve Horton, Andrzej Bednarz, Robert Bartlett, Warwick Butt
We describe our experience of 30 consecutive children supported with ECMO and receiving 20 ppm of nitric oxide in the oxygenator of the ECMO circuit. Administration of nitric oxide into the ECMO circuit is safe and could potentially mitigate ischaemia reperfusion injury and end-organ dysfunction of children requiring mechanical support.
July 1, 2017: Perfusion
https://www.readbyqxmd.com/read/28730549/creation-and-curation-of-the-society-of-imaging-informatics-in-medicine-hackathon-dataset
#2
Marc Kohli, James J Morrison, Judy Wawira, Matthew B Morgan, Jason Hostetter, Brad Genereaux, Mohannad Hussain, Steve G Langer
In order to support innovation, the Society of Imaging Informatics in Medicine (SIIM) elected to create a collaborative computing experience called a "hackathon." The SIIM Hackathon has always consisted of two components, the event itself and the infrastructure and resources provided to the participants. In 2014, SIIM provided a collection of servers to participants during the annual meeting. After initial server setup, it was clear that clinical and imaging "test" data were also needed in order to create useful applications...
July 20, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/28730190/comparison-of-halide-receptors-based-on-h-halogen-chalcogen-pnicogen-and-tetrel-bonds
#3
Steve Scheiner
A series of halide receptors are constructed and the geometries and energetics of their binding to F(-), Cl(-), and Br(-) assessed by quantum calculations. The dicationic receptors are based on a pair of imidazolium units, connected via a benzene spacer. The imidazoliums each donate a proton to a halide in a pair of H-bonds. Replacement of the two bonding protons by Br leads to binding via a pair of halogen bonds. Likewise, chalcogen, pnicogen, and tetrel bonds occur when the protons are replaced, respectively, by Se, As, and Ge...
July 21, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28730155/surveillance-study-of-influenza-occurrence-and-immunity-in-a-wisconsin-cohort-during-the-2009-pandemic
#4
Chia-Yun Lo, Susan L Strobl, Kimberly Dunham, Wei Wang, Lucy Stewart, Julia A Misplon, Mayra Garcia, Jin Gao, Tatsuhiko Ozawa, Graeme E Price, Jose Navidad, Steve Gradus, Sanjib Bhattacharyya, Cecile Viboud, Maryna C Eichelberger, Carol D Weiss, Jack Gorski, Suzanne L Epstein
BACKGROUND: Antibody and T-cell immunity to conserved influenza virus antigens can protect animals against infection with diverse influenza strains. Although immunity against conserved antigens occurs in humans, whether such responses provide cross-protection in humans and could be harnessed as the basis for universal influenza vaccines is controversial. The 2009 pandemic provided an opportunity to investigate whether pre-existing cross-reactive immunity affected susceptibility to infection...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28729625/stable-isotopes-reveal-diet-shift-from-pre-extinction-to-reintroduced-przewalski-s-horses
#5
Petra Kaczensky, Martina Burnik Šturm, Mikhail V Sablin, Christian C Voigt, Steve Smith, Oyunsaikhan Ganbaatar, Boglarka Balint, Chris Walzer, Natalia N Spasskaya
The Przewalski's horse (Equus ferus przewalskii), the only remaining wild horse within the equid family, is one of only a handful of species worldwide that went extinct in the wild, was saved by captive breeding, and has been successfully returned to the wild. However, concerns remain that after multiple generations in captivity the ecology of the Przewalski's horse and / or the ecological conditions in its former range have changed in a way compromising the species' long term survival. We analyzed stable isotope chronologies from tail hair of pre-extinction and reintroduced Przewalski's horses from the Dzungarian Gobi and detected a clear difference in the isotopic dietary composition...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28728570/health-promotion-interventions-for-community-dwelling-older-people-with-mild-or-pre-frailty-a-systematic-review-and-meta-analysis
#6
Rachael Frost, Celia Belk, Ana Jovicic, Federico Ricciardi, Kalpa Kharicha, Benjamin Gardner, Steve Iliffe, Claire Goodman, Jill Manthorpe, Vari M Drennan, Kate Walters
BACKGROUND: Mild or pre-frailty is common and associated with increased risks of hospitalisation, functional decline, moves to long-term care, and death. Little is known about the effectiveness of health promotion in reducing these risks. This systematic review aimed to synthesise randomised controlled trials (RCTs) evaluating home and community-based health promotion interventions for older people with mild/pre-frailty. METHODS: We searched 20 bibliographic databases and 3 trials registers (January 1990 - May 2016) using mild/pre-frailty and associated terms...
July 20, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28727758/longevity-effect-of-a-polysaccharide-from-chlorophytum-borivilianum-on-caenorhabditis-elegans-and-saccharomyces-cerevisiae
#7
Steve Thomas Pannakal, Sibylle Jäger, Albert Duranton, Amit Tewari, Subarna Saha, Aneesha Radhakrishnan, Nita Roy, Jean François Kuntz, Soraya Fermas, Darryl James, Jane Mellor, Namita Misra, Lionel Breton
The traditional Indian medicine, Ayurveda, provides insights and practical solutions towards a healthy life style. Rasayana is a branch of Ayurveda known for preserving and promoting health, enhancing the quality of life and delaying the aging process. In the traditional knowledge, the Rasayana herb, Chlorophytum borivilianum (C. borivilanum) is regarded as a general health promoting tonic that delays aging and increases lifespan, cognitive function and physical strength. Aging is a complex and multifactorial physiological phenomenon that manifests itself over a wide range of biological systems, tissues, and functions...
2017: PloS One
https://www.readbyqxmd.com/read/28727604/preclinical-development-of-ebi-005-an-il-1-receptor-1-inhibitor-for-the-topical-ocular-treatment-of-ocular-surface-inflammatory-diseases
#8
Joseph Kovalchin, Bracken King, Allyson Masci, Elizabeth Hopkins, Jeremy Fry, Jay Hou, Christian Li, Kelly Tenneson, Steve Weber, Gary Wolfe, Kathy Collins, Eric S Furfine
OBJECTIVE: Topical interleukin (IL)-1 receptor (R)1 blockade is therapeutically active in reducing signs and symptoms of dry eye disease. Herein, we describe in vitro and in vivo nonclinical Investigational New Drug (IND)-enabling studies of EBI-005, a novel protein chimera of IL-1β and IL-1 receptor antagonist (IL-1Ra or anakinra) that potently binds IL-1R1 and blocks signaling. These studies provide an assessment of receptor affinity, drug bioavailability, immunogenic response, safety, and tolerability in mice and rabbits...
July 18, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28727496/modulation-of-vegf-induced-migration-and-network-formation-by-lymphatic-endothelial-cells-roles-of-platelets-and-podoplanin
#9
Stacey A Langan, Leyre Navarro-Núñez, Steve P Watson, Gerard B Nash
Lymphatic endothelial cells (LEC) express the transmembrane receptor podoplanin whose only known endogenous ligand CLEC-2 is found on platelets. Both podoplanin and CLEC-2 are required for normal lymphangiogenesis as mice lacking either protein develop a blood-lymphatic mixing phenotype. We investigated the roles of podoplanin and its interaction with platelets in migration and tube formation by LEC. Addition of platelets or antibody-mediated crosslinking of podoplanin inhibited LEC migration induced by vascular endothelial growth factors (VEGF-A or VEGF-C), but did not modify basal migration or the response to basic fibroblast growth factor or epidermal growth factor...
July 20, 2017: Platelets
https://www.readbyqxmd.com/read/28727142/genomic-and-transcriptomic-heterogeneity-of-colorectal-tumors-arising-in-lynch-syndrome
#10
Hans Binder, Lydia Hopp, Michal R Schweiger, Steve Hoffmann, Frank Jühling, Martin Kerick, Bernd Timmermann, Susann Siebert, Christina Grimm, Lilit Nersisyan, Arsen Arakelyan, Maria Herberg, Peter Buske, Henry Loeffler-Wirth, Maciej Rosolowski, Christoph Engel, Jens Przybilla, Martin Peifer, Nicolaus Friedrichs, Gabriela Moeslein, Margarete Odenthal, Michelle Hussong, Sophia Peters, Stefanie Holzapfel, Jacob Nattermann, Robert Hueneburg, Wolff Schmiegel, Brigitte Royer-Pokora, Stefan Aretz, Michael Kloth, Matthias Kloor, Reinhard Buettner, Jörg Galle, Markus Loeffler
Colorectal cancer (CRC) arising in Lynch Syndrome (LS) comprises tumors with constitutional mutations in DNA mismatch-repair genes. Whole-genome and transcriptome studies of LS-CRC are still missing to address questions about similarities and differences of mutation and gene expression characteristics between LS-CRC and sporadic CRC, about the molecular heterogeneity of LS-CRC and about specific mechanisms of LS-CRC genesis linked to dysfunctional mismatch-repair in LS colonic mucosa and the possible role of immune editing...
July 20, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28726463/steven-steve-walfish-1953-2016
#11
Nadine J Kaslow, Amanda M Woods, Jeffrey Zimmerman
Presents an obituary for Steven (Steve) Walfish, who passed away in Atlanta, Georgia, on April 27, 2016. Walfish was a passionate clinical scholar and educator for independent practitioners. Well respected for his evaluations and consultations (presurgical weight loss, substance abuse, psychiatric issues), he became the go-to person for referrals for evidence-based practice with adults and couples. His untimely death to cancer deeply saddened the innumerable clients whose lives he touched and his diverse professional collaborators...
July 2017: American Psychologist
https://www.readbyqxmd.com/read/28725334/bloch-surface-wave-coupled-emission-at-ultra-violet-wavelengths
#12
Ramachandram Badugu, Jieying Mao, Steve Blair, Douguo Zhang, Emiliano Descrovi, Angelo Angelini, Yiping Huo, Joseph R Lakowicz
The interaction of fluorophores with nearby metallic structures is now an active area of research. Dielectric photonic structures offer some advantages over plasmonic structures, namely small energy losses and less quenching. We describe a dielectric one-dimensional photonic crystal (1DPC), which supports Bloch surface waves (BSWs) from 280 to 440 nm. This BSW structure is a quartz slide coated with alternating layers of SiO2 and Si3N4. We show that this structure displays BSWs and that the near-UV fluorophore, 2-aminopurine (2-AP), on the top surface of the structure couples with the BSWs...
December 22, 2016: Journal of Physical Chemistry. C, Nanomaterials and Interfaces
https://www.readbyqxmd.com/read/28725281/introduction-testing-and-refining-marc-lewis-s-critique-of-the-brain-disease-model-of-addiction
#13
Anke Snoek, Steve Matthews
In this introduction we set out some salient themes that will help structure understanding of a complex set of intersecting issues discussed in this special issue on the work of Marc Lewis: (1) conceptual foundations of the disease model, (2) tolerating the disease model given socio-political environments, and (3) A third wave: refining conceptualization of addiction in the light of Lewis's model.
2017: Neuroethics
https://www.readbyqxmd.com/read/28724697/facts-and-values-on-the-acceptability-of-risks-in-children-s-sport-using-the-example-of-rugby-a-narrative-review
#14
REVIEW
Kenneth Lincoln Quarrie, John H M Brooks, Nicholas Burger, Patria A Hume, Steve Jackson
A clash of values has been identified between those who assert that:1. all childhood injuries, regardless of origin, are inherently undesirable and should be prevented and;2. those who believe that some measure of injury to children is an acceptable compromise for the physical benefits associated with physical activity and the development of abilities to appraise and deal with risks.A debate regarding whether the tackles and collisions permitted in schools' rugby represent acceptable risks, and what steps should be taken if they do not, exemplifies the issue...
August 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28724617/human-venous-valve-disease-caused-by-mutations-in-foxc2-and-gjc2
#15
Oliver Lyons, Prakash Saha, Christopher Seet, Adam Kuchta, Andrew Arnold, Steven Grover, Victoria Rashbrook, Amélie Sabine, Gema Vizcay-Barrena, Ash Patel, Francesca Ludwinski, Soundrie Padayachee, Tsutomu Kume, Brenda R Kwak, Glen Brice, Sahar Mansour, Pia Ostergaard, Peter Mortimer, Steve Jeffery, Nigel Brown, Taija Makinen, Tatiana V Petrova, Bijan Modarai, Alberto Smith
Venous valves (VVs) prevent venous hypertension and ulceration. We report that FOXC2 and GJC2 mutations are associated with reduced VV number and length. In mice, early VV formation is marked by elongation and reorientation ("organization") of Prox1(hi) endothelial cells by postnatal day 0. The expression of the transcription factors Foxc2 and Nfatc1 and the gap junction proteins Gjc2, Gja1, and Gja4 were temporospatially regulated during this process. Foxc2 and Nfatc1 were coexpressed at P0, and combined Foxc2 deletion with calcineurin-Nfat inhibition disrupted early Prox1(hi) endothelial organization, suggesting cooperative Foxc2-Nfatc1 patterning of these events...
July 19, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28724460/health-and-well-being-promotion-strategies-for-hard-to-reach-older-people-in-england-a-mapping-exercise
#16
Steve Iliffe, Kate Walters, Jill Manthorpe, Claire Goodman, Kalpa Kharicha
BACKGROUND: Older people from deprived areas, the oldest old and those from ethnic minorities engage less in health promotion interventions and related research, potentially generating inequities. Aim To explore and map the extent to which such 'hard to reach' groups of older people, are the focus of local health and well-being strategies in England. METHODS: Document analysis of current health and well-being promotion strategies in a purposive sample of 10 localities in England with high proportions of some or all of the three hard to reach groups...
July 20, 2017: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/28724390/examining-the-impact-of-a-province-wide-physical-education-policy-on-secondary-students-physical-activity-as-a-natural-experiment
#17
Erin Hobin, Tannis Erickson, Melisa Comte, Fei Zuo, Saamir Pasha, Donna Murnaghan, Steve Manske, Catherine Casey, Jane Griffith, Jonathan McGavock
BACKGROUND: The purpose of this paper is to examine the impact of a province-wide physical education (PE) policy on secondary school students' moderate to vigorous physical activity (MVPA). METHODS: Policy: In fall 2008, Manitoba expanded a policy requiring a PE credit for students in grades 11 and 12 for the first time in Canada. The PE curriculum requires grades 11 and 12 students to complete a minimum of 55 h (50% of course hours) of MVPA (e.g., ≥30 min/day of MVPA on ≥5 days a week) during a 5-month semester to achieve the course credit...
July 19, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28724164/predictive-characteristics-of-elevated-1-hour-glucose-challenge-test-results-for-gestational-diabetes
#18
Alan T N Tita, Yinglei Lai, Mark B Landon, Susan M Ramin, Brian Casey, Ronald J Wapner, Michael W Varner, John M Thorp, Anthony Sciscione, Patrick Catalano, Margaret Harper, George R Saade, Steve N Caritis, Yoram Sorokin, Alan M Peaceman, Jorge E Tolosa
No abstract text is available yet for this article.
July 19, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28724064/genetic-characterization-of-the-soybean-nested-association-mapping-population
#19
Qijian Song, Long Yan, Charles Quigley, Brandon D Jordan, Edward Fickus, Steve Schroeder, Bao-Hua Song, Yong-Qiang Charles An, David Hyten, Randall Nelson, Katy Rainey, William D Beavis, Jim Specht, Brian Diers, Perry Cregan
A set of nested association mapping (NAM) families was developed by crossing 40 diverse soybean [ (L.) Merr.] genotypes to the common cultivar. The 41 parents were deeply sequenced for SNP discovery. Based on the polymorphism of the single-nucleotide polymorphisms (SNPs) and other selection criteria, a set of SNPs was selected to be included in the SoyNAM6K BeadChip for genotyping the parents and 5600 RILs from the 40 families. Analysis of the SNP profiles of the RILs showed a low average recombination rate...
July 2017: Plant Genome
https://www.readbyqxmd.com/read/28721890/the-prognostic-value-of-braf-c-kit-and-nras-mutations-in-melanoma-patients-with-brain-metastases
#20
Paul W Sperduto, Wen Jiang, Paul D Brown, Steve Braunstein, Penny Sneed, Daniel A Wattson, Helen A Shih, Ananta Bangdiwala, Ryan Shanley, Natalie A Lockney, Kathryn Beal, Emil Lou, Thomas Amatruda, William A Sperduto, John P Kirkpatrick, Norman Yeh, Laurie E Gaspar, Jason K Molitoris, Laura Masucci, David Roberge, James Yu, Veronica Chiang, Minesh Mehta
PURPOSE: Brain metastases are a common problem in patients with melanoma, but little is known about the effect of gene mutations on survival in these patients. METHODS AND MATERIALS: We created a retrospective multi-institutional database of 823 patients with melanoma and brain metastases diagnosed between 2006 and 2015. Clinical parameters, gene mutation status (BRAF, C-KIT, NRAS), and treatment were correlated with survival. Treatment patterns and outcomes were compared with a prior era (1985-2005)...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
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