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https://www.readbyqxmd.com/read/28943223/-the-mouth-of-patients-with-acromegaly
#1
Christine Cortet-Rudelli
Orofacial changes are frequent in acromegaly. Their evolution is slowly progressive. The lips (everted and thickened), the mandibular morphology (prognathism), the tongue (macroglossia), the soft palate and the uvula (increased and thickened), the parodontis (gingival hyperplasia, paradontitis), the teeth (increased interdental spaces, hypercementosis, increased dental mobility, multiple tooth loss) are concerned. Functional consequences are significant (obstructive sleep apnea syndrome, malocclusion, pain of the oral maxillofacial area, decrease of the quality of life)...
September 21, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28940800/orofacial-granulomatosis-in-a-12-year-old-girl-successfully-treated-with-intravenous-pulse-corticosteroid-therapy-and-chloroquine
#2
Jovan Lalosevic, Mirjana Gajic-Veljic, Milos Nikolic
Orofacial granulomatosis, a rare disease in childhood, is characterized by orofacial swelling in the absence of systemic disease. We report the case of a 12-year-old girl with asymptomatic erythematous infiltration of her upper lip, cheeks, and chin that had persisted for more than 2 years; biopsy confirmed granuloma formation. Because a large area was affected, intralesional corticosteroids were inappropriate and six cycles of 3-day intravenous pulse corticosteroid therapy (dexamethasone 1.5mg/kg), repeated once after 4 weeks, was given...
September 21, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28937248/theta-burst-stimulation-in-the-treatment-of-chronic-orofacial-pain-a-randomized-controlled-trial
#3
B Kohútová, J Fricová, M Klírová, T Novák, R Rokyta
Theta burst stimulation (TBS) is a modified form of high-frequency repetitive transcranial magnetic stimulation (rTMS) with promising effect in chronic pain. The aim of our double-blind, sham-controlled, parallel-group, randomized study was to assess an efficacy of intermittent TBS (iTBS) in the treatment of patients with chronic orofacial pain. Nineteen patients (twelve females) with chronic orofacial pain were prospectively included and randomly assigned to single session of an active (iTBS) or sham (intermediate TBS; imTBS) stimulation delivered to the primary motor cortex (M1) contralateral to painful side...
September 22, 2017: Physiological Research
https://www.readbyqxmd.com/read/28936287/evaluation-of-orthognathic-surgery-on-articular-disc-position-and-temporomandibular-joint-symptoms-in-skeletal-class-ii-patients-a-magnetic-resonance-imaging-study
#4
Gholamreza Firoozei, Shirin Shahnaseri, Hasan Momeni, Parisa Soltani
BACKGROUND: The purpose of orthognathic surgery is to correct facial deformity and dental malocclusion and to obtain normal orofacial function. However, there are controversies of whether orthognathic surgery might have any negative influence on temporomandibular (TM) joint. The purpose of this study was to evaluate the influence of orthognathic surgery on articular disc position and temporomandibular joint symptoms of skeletal CI II patients by means of magnetic resonance imaging. MATERIAL AND METHODS: For this purpose, fifteen patients with skeletal CI II malocclusion, aged 19-32 years (mean 23 years), 10 women and 5 men, from the Isfahan Department of Oral and Maxillofacial Surgery were studied...
August 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28934221/stage-specific-requirement-of-platelet-derived-growth-factor-receptor-%C3%AE-in-embryonic-development
#5
Chen Qian, Carol Wing Yan Wong, Zhongluan Wu, Qiuming He, Huimin Xia, Paul Kwong Hang Tam, Kenneth Kak Yuen Wong, Vincent Chi Hang Lui
BACKGROUND: Platelet-derived growth factor receptor alpha (PDGFRα) is a cell-surface receptor tyrosine kinase for platelet-derived growth factors. Correct timing and level of Pdgfra expression is crucial for embryo development, and deletion of Pdgfra caused developmental defects of multiple endoderm and mesoderm derived structures, resulting in a complex phenotypes including orofacial cleft, spina bifida, rib deformities, and omphalocele in mice. However, it is not clear if deletion of Pdgfra at different embryonic stages differentially affects these structures...
2017: PloS One
https://www.readbyqxmd.com/read/28933667/diagnostic-performance-of-cheeks-appearance-in-sleep-apnea
#6
Aline Prikladnicki, Denis Martinez, Melissa Giacomelli Brunetto, Cintia Zappe Fiori, Maria do Carmo Sfreddo Lenz, Erissandra Gomes
OBJECTIVE: Obstructive sleep apnea (OSA) is a common, potentially life-threatening, but underdiagnosed condition. The study aimed to test the role of facial myofunctional alterations in OSA screening. METHOD: Sixty-one individuals with sleep complaints were evaluated by the Orofacial Myofunctional Evaluation with Scores (OMES) protocol before undergoing polysomnography. The performance of each of the protocol scores in OSA screening was tested. RESULTS: The nonparametric correlation of the apnea-hypopnea index (AHI) was significant for 18 of the 41 variables of the OMES protocol...
September 21, 2017: Cranio: the Journal of Craniomandibular Practice
https://www.readbyqxmd.com/read/28929829/quantitative-sensory-testing-for-assessment-of-somatosensory-function-in-human-oral-mucosa-a-review
#7
Pin Zhou, Yaming Chen, Jinglu Zhang, Kelun Wang, Peter Svensson
OBJECTIVE: This narrative review provides an overview of the quantitative sensory testing (QST) to assess somatosensory function in human oral mucosa. MATERIAL AND METHODS: A literature search was conducted in the PubMed database to identify studies in vivo on human oral mucosa using QST methods. A list of 149 articles was obtained and screened. A total of 36 relevant articles remained and were read in full text. Manual search of the reference lists identified eight additional relevant studies...
September 20, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/28929054/prosthetic-rehabilitation-of-a-geriatric-patient-with-squamous-cell-carcinoma-of-the-buccal-mucosa-a-report-of-clinical-challenges
#8
Raghavendra Adaki, Sarvesh Raikar, Kamal Shigli, Sivaranjani Gali
OBJECTIVE: This article aims to highlight the rehabilitation of a geriatric patient with an orofacial cheek defect by an extraoral silicone prosthesis. METHODOLOGY: Structured extra- and intra-oral examination of tissues coupled with a justified choice of impression materials, techniques, and prosthetic rehabilitation with a high-temperature vulcanizing silicone was done. RESULTS: The presence of compressible tissues, static appearance of the prosthesis during patient's facial movements, variability in complexion of the skin around the defect, and manipulating heat-vulcanized silicone were the challenges faced during clinical procedures...
April 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/28928994/foxe1-mutation-screening-in-a-case-with-cleft-lip-hypothyroidism-and-thyroid-carcinoma-a-new-syndrome
#9
Hugo Mendieta-Zerón, Angélica Jiménez-Rosales, Carlos Jhovani Pérez-Amado, Silvia Jiménez-Morales
A 26-year-old woman is referred to the Internal Medicine consultation due to increases in laboratory studies associated with Papillary Thyroid Carcinoma (PTC) that was confirmed by histopathological studies. Her clinical history revealed that, at 3 months of age, she was successfully treated with surgery for cleft lip (CL) and at the age of 24 years was diagnosed with hypothyroidism. Single nucleotide polymorphisms (SNPs) in FOXE1 and its promoter regions have been associated with various etiologies related to the thyroid, including orofacial clefting, specially cleft palate (CP) and CL, hypothyroidism (HT), and thyroid cancer...
2017: Case Reports in Genetics
https://www.readbyqxmd.com/read/28920970/-mind-your-teeth-the-relationship-between-mastication-and-cognition
#10
R A F Weijenberg, S Delwel, B V Ho, C D Wierink, F Lobbezoo
Elderly persons, especially those suffering from dementia, are at great risk of suffering from oral health problems such as orofacial pain and loss of natural teeth. A possible explanation could be that the cognitive and motor impairments resulting from dementia cause a decrease in self-care and as such, a worsening of oral health. An alternative explanation is that cognition and oral health influence each other. Animal studies show that a decrease in masticatory activity, for example due to a soft diet or loss of teeth, causes memory loss and neuronal degeneration...
September 2017: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/28906376/nucleotide-variants-of-the-nat2-and-egf61-genes-in-patients-in-northern-china-with-nonsyndromic-cleft-lip-with-or-without-cleft-palate
#11
Jiaqun Yan, Hongquan Song, Na Mi, Xiaohui Jiao, Yanru Hao
BACKGROUND: Non-syndromic cleft lip with or without cleft palate (NSCL/P) is a common orofacial congenital anomaly. The objective of the present study was to analyze the association of single nucleotide polymorphisms (SNPs) in the NAT2 and EGF61genes with NSCL/P in a Chinese population. METHODS: The frequencies of NAT2 (rs1799929)and EGF61 (rs4444903) gene variations were examined in a group of 285 NSCL/P patients and in 315 controls. Peripheral venous blood samples were collected for DNA extraction...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28892191/psychometric-evaluation-of-a-motor-control-test-battery-of-the-craniofacial-region
#12
Harry von Piekartz, Elisabeth Stotz, Anna Both, Gesa Bahn, Susan Armijo-Olivo, Nikolaus Ballenberger
BACKGROUND: The primary objective of this study was to determine the structural and known-group validity as well as the inter-rater reliability of a test battery to evaluate the motor control of the craniofacial region. METHODS: 70 volunteers without TMD and 25 subjects with TMD (Axes I) per the DC/TMD were asked to execute a test battery consisting of eight tests. The tests were videotaped in the same sequence in a standardized manner. Two experienced physical therapists participated in this study as blinded assessors...
September 11, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28885456/tumor-necrosis-factor-alpha-secreted-from-oral-squamous-cell-carcinoma-contributes-to-cancer-pain-and-associated-inflammation
#13
Nicole N Scheff, Yi Ye, Aditi Bhattacharya, Justin MacRae, Dustin H Hickman, Atul K Sharma, John C Dolan, Brian L Schmidt
Oral cancer patients report severe pain during function. Inflammation plays a role in the oral cancer microenvironment; however, the role of immune cells and associated secretion of inflammatory mediators in oral cancer pain has not been well defined. In this study, we utilized two oral cancer mouse models: a cell line supernatant injection model and the 4-nitroquinoline-1-oxide (4NQO) chemical carcinogenesis model. We used the two models to study changes in immune cell infiltrate and orofacial nociception associated with oral squamous cell carcinoma (oSCC)...
September 1, 2017: Pain
https://www.readbyqxmd.com/read/28884971/testing-the-face-shape-hypothesis-in-twins-discordant-for-nonsyndromic-orofacial-clefting
#14
Jasmien Roosenboom, Karlijne Indencleef, Greet Hens, Hilde Peeters, Kaare Christensen, Mary L Marazita, Peter Claes, Elizabeth J Leslie, Seth M Weinberg
Nonsyndromic orofacial clefts (OFCs) are complex traits characterized by multifactorial inheritance and wide phenotypic variability. Numerous studies have shown subtle differences in the faces of unaffected relatives from cleft families compared to controls, the implication being that such outward differences are an incomplete expression reflecting an underlying genetic predisposition. Twins discordant for OFCs provide a unique opportunity to further test this idea, as the unaffected co-twin shares on average 50% (for dizygotic twins) and 100% (for monozygotic twins) of the genetic risk factors as the affected twin...
September 8, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28884307/the-role-of-the-transient-receptor-potential-ankyrin-type-1-trpa1-channel-in-migraine-pain-evaluation-in-an-animal-model
#15
Chiara Demartini, Cristina Tassorelli, Anna Maria Zanaboni, Germana Tonsi, Oscar Francesconi, Cristina Nativi, Rosaria Greco
BACKGROUND: Clinical and experimental studies have pointed to the possible involvement of the transient receptor potential ankyrin type-1 (TRPA1) channels in migraine pain. In this study, we aimed to further investigate the role of these channels in an animal model of migraine using a novel TRPA1 antagonist, ADM_12, as a probe. METHODS: The effects of ADM_12 on nitroglycerin-induced hyperalgesia at the trigeminal level were investigated in male rats using the quantification of nocifensive behavior in the orofacial formalin test...
September 7, 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28883834/ameloblastic-fibroodontoma-uncommon-case-presentation-in-a-6-year-old-child-with-review-of-the-literature
#16
Anshad Mohamed Abdulla, G Sivadas, L K Surej Kumar, C S Sheejith Hari Peeceeyen, Vaishnavi Vedam
Ameloblastic fibroodontoma is a benign mixed odontogenic neoplasm considered in patients with asymptomatic swelling and unerupted teeth that exhibit histologic features between ameloblastic fibroma and complex odontoma. Radiographically, this lesion appears as radiolucency admixed with focal radio opaque masses of irregular shapes and sizes. This lesion is confirmed by the presence of proliferating odontogenic epithelium, ectomesenchyme, and dental hard tissue formation on pathological analysis supplementing clinical and radiographic findings...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28882631/neurochemical-dynamics-of-acute-orofacial-pain-in-the-human-trigeminal-brainstem-nuclear-complex
#17
Nuno M P de Matos, Andreas Hock, Michael Wyss, Dominik A Ettlin, Mike Brügger
The trigeminal brainstem sensory nuclear complex is the first central relay structure mediating orofacial somatosensory and nociceptive perception. Animal studies suggest a substantial involvement of neurochemical alterations at such basal CNS levels in acute and chronic pain processing. Translating this animal based knowledge to humans is challenging. Human related examining of brainstem functions are challenged by MR related peculiarities as well as applicability aspects of experimentally standardized paradigms...
September 4, 2017: NeuroImage
https://www.readbyqxmd.com/read/28880940/development-of-body-head-and-brain-features-in-the-australian-fat-tailed-dunnart-sminthopsis-crassicaudata-marsupialia-dasyuridae-a-postnatal-model-of-forebrain-formation
#18
Rodrigo Suárez, Annalisa Paolino, Peter Kozulin, Laura R Fenlon, Laura R Morcom, Robert Englebright, Patricia J O'Hara, Peter J Murray, Linda J Richards
Most of our understanding of forebrain development comes from research of eutherian mammals, such as rodents, primates, and carnivores. However, as the cerebral cortex forms largely prenatally, observation and manipulation of its development has required invasive and/or ex vivo procedures. Marsupials, on the other hand, are born at comparatively earlier stages of development and most events of forebrain formation occur once attached to the teat, thereby permitting continuous and non-invasive experimental access...
2017: PloS One
https://www.readbyqxmd.com/read/28879245/effects-of-high-dose-capsaicin-on-tmd-subjects-a-randomized-clinical-study
#19
B K Campbell, R B Fillingim, S Lee, R Brao, D D Price, J K Neubert
Temporomandibular joint disorder (TMD) is a complex musculoskeletal disorder that presents with pain, limited jaw opening, and abnormal noises in the temporomandibular joint. Despite the significant impact that TMD has in terms of suffering and financial burden, relatively few new treatments have emerged; therefore, development of novel treatments to treat TMD pain remains a high priority. The rationale of this study was to use a double-blind, vehicle-controlled clinical trial to evaluate the effects of a high-concentration (8%) capsaicin cream on TMD...
January 2017: JDR Clinical and Translational Research
https://www.readbyqxmd.com/read/28879244/care-pathways-in-persistent-orofacial-pain-qualitative-evidence-from-the-deep-study
#20
M Breckons, S M Bissett, C Exley, V Araujo-Soares, J Durham
Persistent orofacial pain is relatively common and known to have an adverse effect on quality of life. Previous studies suggest that the current care pathway may be problematic, but it is not well understood which health services patients access and what their experience is. The aim of this study was to explore care pathways and their impact from the perspective of patients. Qualitative interviews were conducted with a maximum variation sample of patients recruited from primary (community based) and secondary (specialist hospital based) care in the United Kingdom...
January 2017: JDR Clinical and Translational Research
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