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https://www.readbyqxmd.com/read/28646847/prevalence-of-birth-defects-in-iran-a-systematic-review-and-meta-analysis
#1
Yadollah Zahed Pasha, Amin Vahedi, Mohammad Zamani, Reza Alizadeh-Navaei, Ermia Zahed Pasha
INTRODUCTION: Birth defects are a series of disorders that occur during embryonic life. In Iran, no national situation analysis is available to show the rate of congenital disorders. We aimed to estimate the prevalence of structural birth defects in Iran. METHODS: We searched for English studies on PubMed, Scopus and Google Scholar from January 1990 to July 2016. The search for Persian articles was performed in Scientific Information Database and Magiran. Two reviewers assessed the identified articles independently...
June 1, 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28643911/effects-of-cocoa-enriched-diet-on-orofacial-pain-in-a-murine-model
#2
L N Bowden, E L Rohrs, K Omoto, P L Durham, L S Holliday, A D Morris, K D Allen, R M Caudle, J K Neubert
OBJECTIVES: To investigate and discuss the effects of cocoa on orofacial pain. SETTING AND SAMPLE POPULATION: The Department of Orthodontics at the University of Florida (UF). Male and female hairless rats (N=20/group) were tested. MATERIALS AND METHODS: Rats were tested using the Orofacial Pain Assessment Device (OPAD) before and after changing their food from the standard chow to a cocoa-enriched or control-equivalent diet. RESULTS: Male rats fed the cocoa diet had a significantly higher operant pain index when tested at 37°C as compared to control diet-fed animals...
June 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28643456/irf6-expression-in-basal-epithelium-partially-rescues-irf6-knockout-mice
#3
Youssef A Kousa, Dina Moussa, Brian C Schutte
BACKGROUND: Mutations in IRF6, CHUK (IKKA) and RIPK4 can lead to a disease spectrum that includes cutaneous, limb and craniofacial malformations. Loss of these alleles in the mouse leads to perinatal lethality and severe cutaneous, limb and craniofacial defects. Genetic rescue in the mouse has been shown for Ikka and Ripk4. RESULTS: Here, we show partial genetic rescue of Irf6 knockout embryos using the KRT14 promoter to drive Irf6 expression in the basal epithelium...
June 23, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28641484/protective-effect-of-hesperetin-against-haloperidol-induced-orofacial-dyskinesia-and-catalepsy-in-rats
#4
Dinesh Dhingra, Shikha Goswami, Nidhi Gahalain
OBJECTIVES: The present study was designed to evaluate the effect of hesperetin on haloperidol-induced orofacial dyskinesia and catalepsy in Wistar male albino rats. METHODS: Haloperidol (1 mg/kg, ip) was administered for 21 successive days to induce orofacial dyskinesia and catalepsy. Hesperetin (50 and 100 mg/kg, po) was administered 10 min prior to the injection of haloperidol for 21 successive days. Vacuous chewing movements (VCMs), tongue protrusions, catalepsy, and locomotor activity scores were recorded on 7th, 14th, and 22nd day of drug treatment...
June 22, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28639378/regulation-of-the-fate-of-dental-derived-mesenchymal-stem-cells-using-engineered-alginate-gelma-hydrogels
#5
Sahar Ansari, Patricia Sarrion, Mohammad Mahdi Hasani-Sadrabdi, Tara Aghaloo, Benjamin M Wu, Alireza Moshaverinia
Mesenchymal stem cells (MSCs) derived from dental and orofacial tissues provide an alternative therapeutic option for craniofacial bone tissue regeneration. However, there is still a need to improve stem cell delivery vehicles to regulate the fate of the encapsulated MSCs for high quality tissue regeneration. Matrix elasticity plays a vital role in MSC fate determination. Here we have prepared various hydrogel formulations based on alginate and gelatin methacryloyl (GelMA) and have encapsulated gingival mesenchymal stem cells (GMSCs) and human bone marrow MSCs (hBMMSCs) within these fabricated hydrogels...
June 22, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28638895/chronic-orofacial-pain-burning-mouth-syndrome-and-other-neuropathic-disorders
#6
Raymond C Tait, McKenzie Ferguson, Christopher M Herndon
Chronic orofacial pain is a symptom associated with a wide range of neuropathic, neurovascular, idiopathic, and myofascial conditions that affect a significant proportion of the population. While the collective impact of the subset of the orofacial pain disorders involving neurogenic and idiopathic mechanisms is substantial, some of these are relatively uncommon. Hence, patients with these disorders can be vulnerable to misdiagnosis, sometimes for years, increasing the symptom burden and delaying effective treatment...
March 2017: Journal of Pain Management & Medicine
https://www.readbyqxmd.com/read/28637974/neuron-glia-interaction-is-a-key-mechanism-underlying-persistent-orofacial-pain
#7
Koichi Iwata, Ayano Katagiri, Masamichi Shinoda
Excitability of neurons in the trigeminal ganglion (TG), trigeminal spinal subnucleus caudalis (Vc), and upper cervical spinal cord (C1-C2) is greatly enhanced after orofacial inflammation and trigeminal nerve injury, and TG, Vc, and C1-C2 neurons remain sensitized long after such episodes. Sensitized neurons generate various molecules, which are released from nociceptive neurons in these areas and are involved in modulating the excitability of TG, Vc, and C1-C2 nociceptive neurons. Hyperexcitable nociceptive neurons also activate satellite glial cells in the TG and microglial cells and astrocytes in the Vc and C1-C2...
2017: Journal of Oral Science
https://www.readbyqxmd.com/read/28637763/analysis-of-hsv-reactivation-in-explant-reveals-a-method-dependent-difference-in-measured-timing-of-reactivation
#8
Jessica R Doll, Nancy M Sawtell
Herpes simplex virus (HSV) infection is widespread in the human population. Following orofacial infection, HSV establishes latency in innervating sensory neurons, primarily located in the trigeminal ganglia. A central feature of HSV pathogenesis is the ability to periodically reactivate in those neurons and transport back to the body surface. Both transmission and disease; such as keratitis, encephalitis, and neurodegeneration, have been linked to reactivation. Despite invaluable insights obtained from model systems, interactions between viral and host functions that regulate reactivation are still incompletely understood...
June 21, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28635078/prevalence-of-orofacial-clefts-among-live-births-in-china-a-systematic-review-and-meta-analysis
#9
REVIEW
Mengying Wang, Yuan Yuan, Zifan Wang, Dongjing Liu, Zhuqing Wang, Feng Sun, Ping Wang, Hongping Zhu, Jing Li, Tao Wu, Terri H Beaty
BACKGROUND: Orofacial clefts (OFCs) are common human birth defects in China. However, studies on the prevalence of OFCs present inconsistent results. The overall prevalence and geographic distribution of OFCs are poorly described in China. Thus, we conducted a systematic review and meta-analysis to estimate the prevalence of OFCs. METHODS: The systematic review and meta-analysis were conducted on the basis of an established protocol (PROSPERO 2015: CRD42015030198)...
June 21, 2017: Birth defects research
https://www.readbyqxmd.com/read/28632881/clinically-available-assessment-measures-for-lingual-and-labial-somatosensation-in-healthy-adults-normative-data-and-test-reliability
#10
Nicole M Etter, Olivia M Miller, Kirrie J Ballard
Purpose: High-quality orofacial somatosensory inputs are essential for achieving rapid and accurate motor outputs. Little somatosensory testing is currently being completed in clinical settings. The purpose of this study is to assess the feasibility and test-retest reliability of clinical assessment tools for orofacial somatosensory testing in healthy young adults. Method: A total of 45 healthy young adults (ages 20-41 years) was recruited. Participants reported basic health information, completed pure-tone hearing thresholds, and were assessed using two-point discrimination discs and Von Frey hair detection and discrimination thresholds for bilateral lip and tongue...
June 20, 2017: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28625342/dental-investigation-of-mummies-from-the-capuchin-catacombs-of-palermo-circa-18th-19th-century-ce
#11
R Seiler, D Piombino-Mascali, F Rühli
Within the framework of the Sicily Mummy Project, the orofacial complex of a significant sample of individuals (n=111) from the Capuchin Catacombs of Palermo, Italy, was inspected. The heads and dentitions of the mummies were documented and the recorded findings described: the state of preservation of skeletal and soft tissues; dental pathologies such as carious lesions and alveolar bone loss; enamel hypoplasia; and ante- and post-mortem tooth loss. Despite limitations in data collection, the oral health of these mummies was assessed and the frequencies of pathologies were compared to those of similar populations...
May 31, 2017: Homo: Internationale Zeitschrift Für die Vergleichende Forschung Am Menschen
https://www.readbyqxmd.com/read/28622208/duloxetine-plasma-concentrations-and-its-effectiveness-in-the-treatment-of-nonorganic-chronic-pain-in-the-orofacial-region
#12
Yuka Kobayashi, Wataru Nagashima, Tatsuya Tokura, Keizo Yoshida, Eri Umemura, Tomoya Miyauchi, Munetaka Arao, Mikiko Ito, Hiroyuki Kimura, Kenichi Kurita, Norio Ozaki
OBJECTIVE: The purpose of this study was to examine the relationship between the pain-relieving effects of duloxetine and its plasma concentrations in patients with burning mouth syndrome and atypical odontalgia characterized by chronic nonorganic pain in the orofacial region. METHODS: We administered duloxetine to 77 patients diagnosed as having burning mouth syndrome or atypical odontalgia for 12 weeks. The initial dose of duloxetine was established as 20 mg/d and was increased to 40 mg/d after week 2...
June 16, 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/28622039/determinants-for-craniofacial-pains-in-children-6-8-years-of-age-the-panic-study
#13
Anu Vierola, Anna Liisa Suominen, Aino-Maija Eloranta, Niina Lintu, Tiina Ikävalko, Matti Närhi, Timo A Lakka
OBJECTIVE: Determinants for orofacial pain, headache, morning headache and painful signs of temporomandibular disorders (TMD) were investigated in prepubertal children. MATERIAL AND METHODS: The participants were a population sample of 439 children aged 6-8 years. Craniofacial pains, eating meals and snacks, sleep bruxism, sleep quality, sleep-disordered breathing (SDB), psychological well-being, parental education and household income were assessed by questionnaires filled out by the parents...
June 16, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/28620640/solitary-fibrous-tumor-of-retromolar-pad-a-rare-challenging-case
#14
Ali Lotfi, Sepideh Mokhtari, Mohammad Moshref, Maryam Shahla, Saede Atarbashi Moghadam
Solitary fibrous tumor has a wide spectrum of histopathologic features and many tumors show similar microscopic features. This similarity poses diagnostic challenges to the pathologists and immunohistochemical analysis is required in many cases. Moreover, it is a rare entity in orofacial region which consequently would make its diagnosis more challenging in oral cavity. The knowledge of various microscopic patterns of this tumor contributes to a proper diagnosis and prevents unnecessary treatment. This study reports a case of solitary fibrous tumor in the retromolar pad area and discusses its various histological features and differential diagnoses...
June 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28620630/etiology-diagnosis-and-management-of-oromandibular-dystonia-an-update-for-stomatologists
#15
REVIEW
Saeed Raoofi, Hooman Khorshidi, Maryam Najafi
Oromandibular dystonia (OMD) is a rare focal neurological disorder that affects mouth, face, and jaws. This comprehensive literature review aimed to summarize the current evidence for etiology, diagnosis, and management of OMD and assess the possibility of dental origin of the disease and dental treatment plans for these patients. Different online databases namely PubMed, Google scholar, and Scopus were searched. The keywords "oromandibular dystonia", "orofaciomandibular dystonia", "orofacial-buccal dystonia", "lingual dystonia", "jaw dystonia", "cranial dystonia", and "adult-onset facial dystonia" were searched in the title and abstract of publications from 1970 to 2016...
June 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28612917/neonatal-exposure-to-monosodium-glutamate-results-in-dysmorphology-of-orofacial-lower-motor-neurons
#16
Lindsey Foran, Chloe Kupelian, Swati Laroia, Jeffrey Esper, Randy Joseph Kulesza
Glutamate is the most abundant excitatory neurotransmitter in the central nervous system, and is stored and released by both neurons and astrocytes. Despite the important role of glutamate as a neurotransmitter, high levels of extracellular glutamate can result in excitotoxicity and apoptosis. Monosodium glutamate (MSG) is a naturally occurring sodium salt of glutamic acid that is used as a flavor enhancer in many processed foods. Neonatal exposure to MSG has been shown to result in neurodegeneration in several forebrain regions, characterized by neuronal loss and neuroendocrine abnormalities...
June 14, 2017: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/28612700/knowledge-gaps-in-oral-and-maxillofacial-surgery-a-systematic-mapping
#17
Marie Österberg, Anders Holmlund, Bo Sunzel, Sofia Tranæus, Svante Twetman, Bodil Lund
OBJECTIVES: The aim of this study was to evaluate available knowledge and identify knowledge gaps within the field of oral and maxillofacial surgery, by systematically collecting and evaluating systematic reviews. Twelve specific domains were selected: surgical removal of teeth, antibiotic and corticosteroid prophylaxis, orofacial infections, dental and facial trauma, orthognathic surgery, reconstructive surgery, benign tumors, cysts, premalignant lesions, oral complications of treatment of malignant tumors, hyperbaric oxygen therapy, temporomandibular joint surgery, cost effectiveness of different surgical treatments, and ethics...
January 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/28606298/-melkersson-rosenthal-syndrome-in-a-young-man
#18
Elisabeth Lauritzen, Andreas P Schjellerup Jørkov
A 24-year-old man presented with orofacial swelling, peripheral facial palsy and fissured tongue. Apart from a previous episode of peripheral palsy, he had no history of illness. Biopsy of the lip, blood tests, magnetic resonance imaging of the head and lumbar puncture showed no pathology. He received systemic prednisone for ten days, and follow-up showed sparse improvement in facial movements. The patient could have been misdiagnosed with Bell's palsy, but the symptoms rather indicated a case of Melkersson-Rosenthal syndrome...
June 12, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28604150/breastfeeding-after-early-repair-of-cleft-lip-in-newborns-with-cleft-lip-or-cleft-lip-and-palate-in-a-baby-friendly-designated-hospital
#19
Iva Burianova, Katarina Kulihova, Veronika Vitkova, Jan Janota
BACKGROUND: Goals of treatment of orofacial cleft are to improve feeding, speech, hearing, and facial appearance. Early surgery brings faster healing, better cosmetic effect, and fewer complications. Breastfeeding rates after early surgery are unknown. Early repair of the cleft lip may influence breastfeeding rates. Research aim: The aim of this study was to evaluate breastfeeding after early repair of the cleft lip in a Baby-Friendly designated hospital. The rate of breastfeeding in newborns with cleft lip was compared to cleft lip and palate...
June 1, 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28603561/distinct-dna-methylation-profiles-in-subtypes-of-orofacial-cleft
#20
Gemma C Sharp, Karen Ho, Amy Davies, Evie Stergiakouli, Kerry Humphries, Wendy McArdle, Jonathan Sandy, George Davey Smith, Sarah J Lewis, Caroline L Relton
BACKGROUND: Epigenetic data could help identify risk factors for orofacial clefts, either by revealing a causal role for epigenetic mechanisms in causing clefts or by capturing information about causal genetic or environmental factors. Given the evidence that different subtypes of orofacial cleft have distinct aetiologies, we explored whether children with different cleft subtypes showed distinct epigenetic profiles. METHODS: In whole-blood samples from 150 children from the Cleft Collective cohort study, we measured DNA methylation at over 450,000 sites on the genome...
2017: Clinical Epigenetics
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