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https://www.readbyqxmd.com/read/29149498/association-between-a-single-nucleotide-polymorphism-in-the-grem1-gene-and-nonsyndromic-orofacial-cleft-in-the-chinese-population
#1
Xiaotong Wang, Hongquan Song, Xiaohui Jiao, Yanru Hao, Wei Zhang, Yuwei Gao, Yong Li, Na Mi, Jiaqun Yan
BACKGROUND: Nonsyndromic orofacial cleft (NSOC) is a common craniofacial deformity among newborns. The GREM1 gene is correlated with orofacial development. The aim of our study was to investigate the association between a single-nucleotide polymorphism in the GREM1 gene and this malformation in the Chinese population. METHODS: The SNaPshot mini sequencing technique was used to genotype the locus rs1258763 of the GREM1 gene in 331 patients with NSOC and 271 individuals in a control group...
November 17, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29140141/short-clinical-examination-for-temporomandibular-symptoms-in-general-practice
#2
Christina Mejersjö, Ove Bertilsson, Karin Bäck
OBJECTIVE: The aims of the study are to assess the reliability of the short clinical examination, and to compare the information gained with a well-known and validated examination, the diagnostic criteria for temporomandibular disorders (DC/TMD). MATERIALS AND METHODS: The study comprises 52 consecutive, newly referred patients at their first visit and examination to an Orofacial Pain and TMD Clinic, 15 years and older, mean age 44 years. The patients first answered three screening questions for reported symptoms...
November 15, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/29134730/role-of-central-versus-peripheral-opioid-system-in-antinociceptive-and-anti-inflammatory-effect-of-botulinum-toxin-type-a-in-trigeminal-region
#3
V Drinovac Vlah, B Filipović, L Bach-Rojecky, Z Lacković
BACKGROUND: Although botulinum toxin type A (BT-A) is approved for chronic migraine treatment, its site and mechanism of action are still elusive. Recently our group discovered that suppression of CGRP release from dural nerve endings might account for antimigraine action of pericranially injected BT-A. We demonstrated that central antinociceptive effect of BT-A in sciatic region involves endogenous opioid system as well. Here we investigated possible interaction of BT-A with endogenous opioid system within the trigeminal region...
November 13, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29133175/role-of-kcnq2-channels-in-orofacial-cold-sensitivity-kcnq2-upregulation-in-trigeminal-ganglion-neurons-after-infraorbital-nerve-chronic-constrictive-injury
#4
Jennifer Ling, Ferhat Erol, Jianguo G Gu
Sensitivity to cooling temperatures often becomes heightened in orofacial regions leading to orofacial cold allodynia/hyperalgesia after chronic trigeminal nerve injury. KCNQ2 channels are involved in controlling excitability of primary afferent neurons and thereby regulate sensory functions under both physiological and pathological conditions. In the present study, we sought to determine whether KCNQ2 channels in trigeminal nerves are involved in regulating orofacial operant behavioral responses to cooling stimulation...
November 10, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29132095/inhibition-of-tnf-reduces-mechanical-orofacial-hyperalgesia-induced-by-complete-freund-s-adjuvant-by-a-trpv1-dependent-mechanism-in-mice
#5
Krzysztof Lis, Tomasz Grygorowicz, Agnieszka Cudna, David E Szymkowski, Ewa Bałkowiec-Iskra
BACKGROUND: Inflammation in the orofacial region results in pain and is associated with many pathological states, including migraine, neuralgias and temporomandibular disorder. Although extensively studied, the mechanisms responsible for these conditions are not known and effective treatments are lacking. We reported earlier that the proinflammatory cytokine tumor necrosis factor (TNF) plays an important role in regulation of trigeminal ganglion (TG) neuron function in vitro. In the present study we investigated the role of TNF in mechanical hypersensitivity in mice...
June 3, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29131694/role-of-neuron-glial-interaction-mediated-by-il-1%C3%AE-in-ectopic-tooth-pain
#6
H Komiya, K Shimizu, N Noma, Y Tsuboi, K Honda, K Kanno, K Ohara, M Shinoda, B Ogiso, K Iwata
Although many reports have demonstrated that ectopic pain develops in the orofacial region following tooth pulp inflammation, which often causes misdiagnosis and inappropriate treatment for patients with pulpitis, the precise mechanism remains unknown. In the present study, we hypothesized that the functional interaction between satellite glial cells and neurons mediated by interleukin 1β (IL-1β) in the trigeminal ganglion (TG) is involved in ectopic orofacial pain associated with tooth pulp inflammation...
November 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29130604/expanding-the-phenotypic-spectrum-of-tp63-related-disorders-including-the-first-set-of-monozygotic-twins
#7
Tara Wenger, Dong Li, Margaret H Harr, Wen-Hann Tan, Renata Pellegrino, Zornitza Stark, Hakon Hakonarson, Elizabeth J Bhoj
Individuals with Tumor Protein P63 (TP63)-related disorders are known to present with a range of phenotypic features, including ectrodactyly, ectodermal dysplasia, cleft lip/palate, Rapp-Hodgkin, Hay-Wells, and limb-mammary syndromes. We present six individuals from three families, including a set of monozygotic twins, with pathogenic TP63 variants who had novel clinical findings. The twins were discordant for cleft lip and palate, and the type of hand malformations, but concordant for choanal atresia, and bilateral volar nail...
November 12, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29126811/properties-of-tonic-episodes-of-masseter-muscle-activity-during-waking-hours-and-sleep-in-subjects-with-and-without-history-of-orofacial-pain
#8
Acing Habibie Mude, Shigehisa Kawakami, Seiya Kato, Shogo Minagi
PURPOSE: To provide a scientific data related to the tonic activity of masseter muscle in subjects with and without history of orofacial pain during their normal daily life. METHODS: Thirty-three subjects were divided into two groups, a pain history group (PHG) and a non-pain history group (non-PHG), based on their responses to the Research Diagnostic Criteria for Temporomandibular Disorders questionnaire. After excluding four subjects with incomplete recordings, full-day masseter muscle surface EMGs of 29 subjects (10 men, 19 women; mean age 24...
November 7, 2017: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/29126490/dental-management-of-patients-who-have-undergone-oral-cancer-therapy
#9
REVIEW
Alessandro Villa, Sunday O Akintoye
Oral cancer therapies are associated with orofacial complications that could result in dose-limiting cancer treatment and consequent suboptimal tumor control. Oral cancer treatment complications include oral mucositis, salivary gland hypofunction, odontogenic infections, pain, dermatitis, neurotoxicity, soft tissue fibrosis, trismus, osteoradionecrosis, and potential cancer recurrence. These complications significantly affect cancer survivorship, quality of life, and psychosocial status. Effective dental management of patients with oral cancer involves the coordination of care among several health care professionals before, during, and after cancer therapy...
January 2018: Dental Clinics of North America
https://www.readbyqxmd.com/read/29124805/identification-of-16q21-as-a-modifier-of-nonsyndromic-orofacial-cleft-phenotypes
#10
Jenna C Carlson, Jennifer Standley, Aline Petrin, John R Shaffer, Azeez Butali, Carmen J Buxó, Eduardo Castilla, Kaare Christensen, Frederic W-D Deleyiannis, Jacqueline T Hecht, L Leigh Field, Ariuntuul Garidkhuu, Lina M Moreno Uribe, Natsume Nagato, Ieda M Orioli, Carmencita Padilla, Fernando Poletta, Satoshi Suzuki, Alexandre R Vieira, George L Wehby, Seth M Weinberg, Terri H Beaty, Eleanor Feingold, Jeffrey C Murray, Mary L Marazita, Elizabeth J Leslie
Orofacial clefts (OFCs) are common, complex birth defects with extremely heterogeneous phenotypic presentations. Two common subtypes-cleft lip alone (CL) and CL plus cleft palate (CLP)-are typically grouped into a single phenotype for genetic analysis (i.e., CL with or without cleft palate, CL/P). However, mounting evidence suggests there may be unique underlying pathophysiology and/or genetic modifiers influencing expression of these two phenotypes. To this end, we performed a genome-wide scan for genetic modifiers by directly comparing 450 CL cases with 1,692 CLP cases from 18 recruitment sites across 13 countries from North America, Central or South America, Asia, Europe, and Africa...
November 10, 2017: Genetic Epidemiology
https://www.readbyqxmd.com/read/29123620/the-effects-of-regular-exercise-on-capsaicin-induced-pulpal-pain-and-pain-induced-changes-in-passive-avoidance-learning-and-memory-in-rats
#11
Maryam Raoof, Afshin Shakoori, Razieh Kooshki, Mehdi Abbasnejad, Sara Amanpour
Background: Pulpal pain is one of the most common and severe orofacial pain conditions with considerable adverse effects on physiological processes including learning and memory. Regular exercise is known to be effective on cognitive function as well as pain processing in the central nervous system. Here, the possible effects of regular exercise on pulpal pain response as well as pain-induced changes in learning and memory efficiency in rats were investigated. Methods: Twenty-four male Wistar rats were randomly assigned to the control, capsaicin, exercise, and exercise plus capsaicin groups...
October 2017: Korean Journal of Pain
https://www.readbyqxmd.com/read/29115541/comparison-of-the-osteogenic-differentiation-of-orofacial-bone-marrow-stromal-cells-prior-to-and-following-marsupialization-in-patients-with-odontogenic-cyst
#12
Yao Sun, Juan Zhang, Naiying Qian, Guoqi Sima, Jianming Zhang, Jiayong Zhong, Zhiqin Guo, Yawen Chen, Weijie Dong
Decompression has been considered a valuable tool for odontogenic cystic lesions to minimize cyst size with low morbidity and recurrence. However, whether decompression has a role in regulating stem cell properties of orofacial bone marrow stromal cells (BMSCs) around the cysts has not been fully investigated. The present study compared the stem cell marker profile and osteogenic differentiation potential of orofacial BMSCs prior to and following marsupialization (pre‑BMSCs vs. post‑BMSCs) in the same individuals...
November 3, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29112008/tlr4-deficiency-abrogated-widespread-tactile-allodynia-but-not-widespread-thermal-hyperalgesia-and-trigeminal-neuropathic-pain-following-partial-infraorbital-nerve-transection
#13
Ting-Ting Hu, Ran-Ran Wang, Ying-Ying Tang, Yu-Xing Wu, Jie Yu, Wei-Wei Hou, Guo-Dong Lou, Yu-Dong Zhou, Shi-Hong Zhang, Zhong Chen
Pain sensitization following partial infraorbital nerve transection (p-IONX) in mice not only presents in orofacial region, but also spreads to distant body parts. The roles of toll like receptor 4 (TLR4) in orofacial pain and the spreading process are still unclear. Here we found that mice with deficient TLR4 due to Tr4 gene point mutation (C3H/HeJ) or spontaneous deletion (C57BL/10ScNJ) developed tactile allodynia and thermal hyperalgesia in the vibrissal pad in a parallel way to their respective wild types (C3HeB/FeJ or C57BL/6J) following p-IONX...
November 3, 2017: Pain
https://www.readbyqxmd.com/read/29106869/check-list-for-the-assessment-of-functional-impairment-in-children-with-congenital-aural-atresia
#14
Silvia Montino, Anna Agostinelli, Patrizia Trevisi, Alessandro Martini, Sara Ghiselli
OBJECTIVES: Congenital Aural Atresia (CAA) is a deformity of the external ear and it is commonly associated with malformations of middle and inner ear and, in some cases, with other facial deformities. Very few assessment measures exist for evaluating the functional impairment in children with CAA. Purpose of this study is to introduce and describe an assessment Checklist, (nominated FOS Checklist) that covers feeding abilities (F), oralmotor skills (O), communication/language development (S) in children with CAA...
November 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29105886/altered-structure-and-functional-connection-in-patients-with-classical-trigeminal-neuralgia
#15
Yuan-Hsiung Tsai, Rui Yuan, Dharni Patel, Subhashini Chandrasekaran, Hsu-Huei Weng, Jen-Tsung Yang, Ching-Po Lin, Bharat B Biswal
Classical trigeminal neuralgia (TN) is a specific type of neuropathic orofacial pain of which the plasticity of brain structure and connectivity have remained largely unknown. A total of 62 TN patients were included and referred to MRI scans. Voxel-based morphometry was used to analyze the change of gray matter volume. Resting-state functional imaging was used to analyze the connectivity between brain regions. The results showed gray matter volume reduction in components of the prefrontal cortex, precentral gyrus, cerebellar tonsil, thalamus, hypothalamus, and nucleus accumbens among right TN patient and in the inferior frontal gyrus, precentral gyrus, cerebellum, thalamus, ventral striatum, and putamen among left TN patients...
November 6, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29104383/comparison-of-dermatoglyphic-pattern-among-cleft-and-noncleft-children-a-cross-sectional-study
#16
Sandeep S Mayall, Seema Chaudhary, Harsimran Kaur, Naveen Manuja, Telegi Ravishankar, Ashish A Sinha
Background: Oral clefts are among the common congenital birth defects with a broad phenotypic gamut. Since the epidermal ridges of the fingers and palms as well as the facial structures like lip, alveolus, and palate are formed from the same embryonic tissues during the same embryonic period, the genetic and environmental factors responsible for causing cleft lip and palate might also affect dermatoglyphic patterns. Aim: Thus, study was undertaken to compare the dermato-glyphic pattern of children with orofacial clefts and normal children and to determine the correlation of dermatoglyphics with orofacial clefts...
July 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/29103943/from-oral-facial-dysfunction-to-dysmorphism-and-the-onset-of-pediatric-osa
#17
REVIEW
Christian Guilleminault, Yu-Shu Huang
The upper airway is a collapsible tube, and its collapsibility increases during sleep. Extrinsic factors such as atypical craniofacial features may increase the risks of airway collapse. We review early development of oral-facial structures and the anatomical variants that may be present at birth and can impact nasal breathing. After birth, there is a continuous interaction between orofacial functions and growth of anatomic features. We review the dysfunctions identified to date that may impact orofacial development leading to sleep-disordered-breathing through changes in the orofacial growth...
July 6, 2017: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/29102165/effect-of-pregabalin-and-diclofenac-on-tactile-allodynia-mechanical-hyperalgesia-and-pro-inflammatory-cytokine-levels-il-6-il-1%C3%AE-induced-by-chronic-constriction-injury-of-the-infraorbital-nerve-in-rats
#18
Junad Khan, Noma Noboru, Yoshiki Imamura, Eli Eliav
The present study evaluated the effects of systemic pregabalin (PG) and diclofenac (Dic) on neuropathic orofacial pain induced by chronic constriction injury (CCI) of the infraorbital nerve (ION) and on the pro-inflammatory cytokines levels in the affected nerve. Fifty-four rats underwent left infra orbital nerve CCI, and 7 days after the procedure as the pain developed, the rats were randomly assigned to one of the treatment groups: PG 300, 30 or 10 mg/kg, Dic 10, 5 or 1 mg/kg or saline group (Sal) (n/group = 8)...
October 25, 2017: Cytokine
https://www.readbyqxmd.com/read/29099371/abuse-potential-of-gabapentin-in-dentistry
#19
Mea A Weinberg, Stuart L Segelnick, Joseph S Insler
Gabapentin is an anticonvulsant drug widely prescribed for various ailments, including orofacial pain. It was once thought to have no potential for abuse; however, the last decade has seen a dramatic rise in the nonmedical use of gabapentin, particularly among opioid-dependent patients. Gabapentin is sedating and interacts with other sedating medications such as opioids, which can lead to impairment and accidents and may raise the risk of overdose. Dentists must be aware of the potential for abuse of gabapentin and weigh its benefits against its risks when prescribing the drug...
November 2017: General Dentistry
https://www.readbyqxmd.com/read/29097820/electrical-stimulation-of-hyoid-muscles-in-post-stroke-dysphagia
#20
Petr Konecny, Milan Elfmark
AIMS: The purpose of this study was to evaluate swallowing changes in post-stroke patients with dysphagia after four weeks of suprahyoid muscles electrical stimulation. METHODS: This was a prospective randomized study of early stage stroke patients with dysphagia. Electrical stimulation of suprahyoid muscles was given to a group of 54 patients (26 men, average age 70 years) for 20 minutes a day, 5 days a week. Standard orofacial rehabilitation without electrical stimulation was carried out on a control group of 54 patients (31 men, average age 69 years)...
November 2, 2017: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
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