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https://www.readbyqxmd.com/read/28210904/acute-and-neuropathic-orofacial-antinociceptive-effect-of-eucalyptol
#1
José de Maria de Albuquerque de Melo Júnior, Marina de Barros Mamede Vidal Damasceno, Sacha Aubrey Alves Rodrigues Santos, Talita Matias Barbosa, João Ronielly Campêlo Araújo, Antonio Eufrásio Vieira-Neto, Deysi Viviana Tenazoa Wong, Roberto César Pereira Lima-Júnior, Adriana Rolim Campos
Terpenes have a wide range of pharmacological properties, including antinociceptive action. The anti-inflammatory and antinociceptive effects of eucalyptol are well established. The purpose of this study was to evaluate the antinociceptive effect of eucalyptol on acute and neuropathic orofacial pain in rodent models. Acute orofacial and corneal nociception was induced with formalin, capsaicin, glutamate and hypertonic saline in mice. In another series, animals were pretreated with capsazepine or ruthenium red to evaluate the involvement of TRPV1 receptors in the effect of eucalyptol...
February 16, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28203028/-unerupted-first-deciduous-molar-located-higher-to-the-first-premolar-a-case-report
#2
Y Zhan, H Liu
Tooth eruption is defined as the movement of a tooth from its site of development within the alveolar process to its functional position in the oral cavity. The process of tooth eruption can be divided into different phases: pre-eruptive bone stage, alveolar bone stage, mucosal stage, preocclusal stage, occlusal stage and maturation stage. Any disturbance in these phases can lead to eruptive anomalies. The incidence of unerupted teeth is usually higher among permanent teeth than among deciduous ones. Of the primary teeth reported as unerupted, second deciduous molars are the teeth most frequently involved, followed by primary central incisors...
February 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28197921/sumoylation-in-craniofacial-disorders
#3
Erwin Pauws, Philip Stanier
Craniofacial development requires a complex series of coordinated and finely tuned events to take place, during a relatively short time frame. These events are set in motion by switching on and off transcriptional cascades that involve the use of numerous signalling pathways and a multitude of factors that act at the site of gene transcription. It is now well known that amidst the subtlety of this process lies the intricate world of protein modification, and the posttranslational addition of the small ubiquitin -like modifier, SUMO, is an example that has been implicated in this process...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28196287/oral-health-related-quality-of-life-in-patients-with-non-metal-clasp-dentures-a-randomized-crossover-trial
#4
Kenji Fueki, Eiko Yoshida-Kohno, Noriyuki Wakabayashi
OBJECTIVES: We investigated the efficacy of non-metal clasp dentures (NMCDs) with regard to the oral-health related quality of life (OHRQoL) and compare the findings with those for conventional metal clasp-retained dentures (MCDs). METHODS: This single-centre, randomized controlled, two-phase, open label, crossover trial included 28 partially dentate individuals. The patients were randomized to receive MCDs followed by NMCDs, or the opposite sequence (n = 14 in each group); each denture was worn for 3 months...
February 14, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28194098/spatiotemporal-profiles-of-proprioception-processed-by-the-masseter-muscle-spindles-in-rat-cerebral-cortex-an-optical-imaging-study
#5
Satoshi Fujita, Mari Kaneko, Hiroko Nakamura, Masayuki Kobayashi
Muscle spindles in the jaw-closing muscles, which are innervated by trigeminal mesencephalic neurons (MesV neurons), control the strength of occlusion and the position of the mandible. The mechanisms underlying cortical processing of proprioceptive information are critical to understanding how sensory information from the masticatory muscles regulates orofacial motor function. However, these mechanisms are mostly unknown. The present study aimed to identify the regions that process proprioception of the jaw-closing muscles using in vivo optical imaging with a voltage-sensitive dye in rats under urethane anesthesia...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28186468/nocifensive-behaviors-in-mice-with-radiation-induced-oral-mucositis
#6
Michael W Nolan, C Tyler Long, Karen L Marcus, Shayan Sarmadi, Donald M Roback, Tomoki Fukuyama, Wolfgang Baeumer, B Duncan X Lascelles
Oral mucositis can result in significant dysphagia, and is the most common dose-limiting acute toxicity in head and neck cancer patients receiving chemoradiotherapy. There is a critical need to determine the cellular and molecular mechanisms that underlie radiotherapy-associated discomfort in patients with mucositis. The objective was to induce oral mucositis in mice, using a clinical linear accelerator, and to quantify resultant discomfort, and characterize peripheral sensitization. A clinical linear accelerator was used to deliver ionizing radiation to the oral cavity of mice...
February 10, 2017: Radiation Research
https://www.readbyqxmd.com/read/28183073/melkersson-rosenthal-syndrome-a-case-report-with-a-psychosomatic-perspective
#7
Patrick Alves, Orlando von Doellinger, Maria Luísa Quintela, Aníbal Fonte, Rui Coelho
Context • The Melkersson-Rosenthal syndrome (MRS) is a rare condition characterized by a triad of symptoms: (1) recurrent and/or persistent orofacial swelling, (2) recurrent facial paralysis, and (3) a fissured tongue. Although various contributing factors have been suggested, the etiology and mechanisms of the syndrome have not been fully elucidated. Objective • The aim of the current study was to examine for the first time some psychosomatic aspects of the syndrome and to evaluate the benefits of a brief psychotherapeutic process in which the research team worked to reintegrate the complex bio-psycho-social functioning of the patient...
January 2017: Advances in Mind-body Medicine
https://www.readbyqxmd.com/read/28181393/blepharocheilodontic-bcd-syndrome-new-insights-on-craniofacial-and-dental-features
#8
Wael Awadh, Anu Kiukkonen, Pekka Nieminen, Sirpa Arte, Kirsti Hurmerinta, David P Rice
Blepharocheilodontic (BCD) syndrome is a rare condition characterized by bilateral cleft lip and palate (BCLP), eyelid abnormalities, and oligodontia. Despite orofacial clefting and oligodontia being central features of the condition, detailed reports of dental and craniofacial characteristics are scarce. The aim of this study was to analyze the dental and craniofacial features in a group of patients with BCD syndrome (three of which were related). Cephalometric radiographic analyses were performed on BCD syndrome patients (all radiographs taken at age 8 years) and compared to 40 randomly selected age-matched controls (20 non-syndromic BCLP, 20 non-cleft)...
February 9, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28180012/seroprevalence-and-co-infection-of-human-immunodeficiency-virus-hiv-and-herpes-simplex-virus-hsv-among-pregnant-women-in-lokoja-north-central-nigeria
#9
Olatunji Matthew Kolawole, Oluwatomi Olufunke Amuda, Charles Nzurumike, Muhammed Mustapha Suleiman, Jeremiah Ikhevha Ogah
BACKGROUND: Herpes simplex virus 1 (HSV-1) is normally associated with orofacial (orolabial) infections and encephalitis, whereas HSV-2 usually causes genital infections and can be transmitted from infected mothers to neonates. The evidence suggesting that HSV is facilitating the spread of the global human immunodeficiency virus (HIV) epidemic and the risk posed by these synergies to neonates in developing countries informed this study. OBJECTIVES: To determine the seroprevalence and co-infection of HIV and HSV, as well as their associated risk factors, in Lokoja, Nigeria...
October 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28174653/eagle-syndrome
#10
Akira Baba, Yumi Okuyama, Hiroya Ojiri, Tsuneya Nakajima
Although rare, Eagle syndrome should be always considered in the differential diagnosis in patients with chronic orofacial pain refractory to conventional treatments. Treatment is surgery and exeresis of the styloid process via a transoral or cervical approach depending on clinical and radiological features.
February 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28168240/cracked-tooth-syndrome-mimicking-trigeminal-autonomic-cephalalgia-a-report-of-four-cases
#11
Noboru Noma, Kohei Shimizu, Kosuke Watanabe, Andrew Young, Yoshiki Imamura, Junad Khan
BACKGROUND: This report describes four cases of cracked tooth syndrome secondary to traumatic occlusion that mimicked trigeminal autonomic cephalalgias. All patients were referred by general practitioners to the Orofacial Pain Clinic at Nihon University Dental School for assessment of atypical facial pain. CLINICAL PRESENTATION: Case 1: A 51-year-old woman presented with severe pain in the maxillary and mandibular left molars. Case 2: A 47-year-old woman presented with sharp, shooting pain in the maxillary left molars, which radiated to the temple and periorbital region...
February 6, 2017: Quintessence International
https://www.readbyqxmd.com/read/28166255/occlusal-stabilization-splint-for-patients-with-temporomandibular-disorders-meta-analysis-of-short-and-long-term-effects
#12
Jovana Kuzmanovic Pficer, Slobodan Dodic, Vojkan Lazic, Goran Trajkovic, Natasa Milic, Biljana Milicic
BACKGROUND: Psychological discomfort, physical disability and functional limitations of the orofacial system have a major impact on everyday life of patients with temporomandibular disorders (TMDs). In this study we sought to determine short and long term effects of stabilization splint (SS) in treatment of TMDs, and to identify factors influencing its efficacy. METHODS: MEDLINE, Web of Science and EMBASE were searched for randomized controlled trials (RCTs) comparing SS to: non-occluding splint, occlusal oral appliances, physiotherapy, behavioral therapy, counseling and no treatment...
2017: PloS One
https://www.readbyqxmd.com/read/28166087/genitourinary-malformations-an-under-recognized-feature-of-ectrodactyly-ectodermal-dysplasia-and-cleft-lip-palate-syndrome
#13
Zerin Hyder, Victoria Beale, Ruth O'Connor, Jill Clayton-Smith
The ectodermal dysplasia and cleft lip/palate (EEC) syndrome describes the association of ectrodactyly, ectodermal dysplasia and orofacial clefting. As with many autosomal dominant disorders, there is variability in expression and not all of these three core features are present in every individual with the condition. Moreover, there may be additional associated features, which are under-recognized. One of these is the presence of genitourinary anomalies, some of which cause significant morbidity. This report details a further two patients with EEC syndrome and genitourinary involvement, including flaccid megacystis with detrusor muscle failure, bilateral hydronephrosis and megaureter, requiring significant renal and urological involvement during their childhood...
February 3, 2017: Clinical Dysmorphology
https://www.readbyqxmd.com/read/28162846/ketamine-xylazine-anaesthesia-and-orofacial-administration-of-substance-p-a-lethal-combination-in-rats
#14
Janetti N Francischi, Taíssa Iolanda C Frade, Marcella P A de Almeida, Bárbara F G de Queiroz, Y S Bakhle
BACKGROUND AND AIMS: Ketamine+xylazine mixture is a widely used anaesthetic in animal experiments. In rats anaesthetized with this mixture, we have shown that injection of carrageenan, a standard proinflammatory stimulus, into the cheek (intra-oral injection) induced oedema. A likely mediator of this oedema is substance P (SP), a major transmitter of sensory nerves in orofacial tissue. We have assessed the effects of intra-oral injection of SP in rats. EXPERIMENTAL APPROACH: SP (50-1μg per rat) was injected intra-orally in male adult Holtzman or Wistar rats, anaesthetized with ketamine+xylazine...
January 23, 2017: Neuropeptides
https://www.readbyqxmd.com/read/28162747/-494-optimizing-resilience-in-orofacial-pain-and-nociception-orion-exploring-the-efficacy-of-a-hope-intervention-for-pain
#15
E Bartley, M Robinson, R Fillingim
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28160523/orofacial-functions-in-experimental-models-of-cerebral-palsy-a-systematic-review
#16
REVIEW
Diego Cabral Lacerda, Kelli Nogueira Ferraz-Pereira, André Terácio, Bárbara Juacy Rodrigues Costa de Santana, Omar Guzman Quevedo, Raul Manhães-de-Castro, Ana Elisa Toscano
BACKGROUND: Children who suffer from cerebral palsy (CP) often present comorbidities in the form of orofacial dysfunctions. Studies in animals have contributed to elaborate potential therapies aimed at minimizing the chronic disability of the syndrome. OBJECTIVE: To systematically review the scientific literature regarding the possible effects that experimental models of CP can have on orofacial functions. METHODS: Two independent authors conducted a systematic review in the electronic databases Medline, Scopus, CINAHL, Web of Science and Lilacs, using Mesh and Decs terms in animal models...
February 4, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28160512/prevalence-of-dental-trauma-and-use-of-mouthguards-in-professional-handball-players
#17
Lana Bergman, Slađana Milardović Ortolan, Davor Žarković, Joško Viskić, Dražen Jokić, Ketij Mehulić
BACKGROUND / AIM: Published data about orofacial injuries and mouthguard use by professional handball players is scarce. The aim of this study was to investigate the prevalence of orofacial trauma and mouthguard use in professional handball players. MATERIALS AND METHODS: Data were collected among 100 professional handball players through a questionnaire which contained 17 questions about age, experience in playing handball, playing position, orofacial trauma experience during the past 12 months, type of injury and mouthguard use...
February 4, 2017: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/28159459/osteoporosis-in-stickler-syndrome-a-new-family-case-with-bone-histology-study
#18
P Insalaco, E Legrand, B Bouvard, M Audran
The Stickler syndrome (SS) has been described as a "hereditary progressive arthro-ophtalmopathy" by Stickler in 1965, due to mutations on the collagen genes. Currently about 40 different genes have been identified which encode for at least 27 different collagens. The majority of mutations occur in the COL2A1 gene on chromosome 12q13 (SS type I). Mutations in COL11A1 are less frequent (SS type II). More recently, mutations in COL11A2 and in the COL9A1 gene have been reported with particular phenotypes. The main features of this autosomal inherited disease are ocular, auditory with orofacial abnormalities and early-onset osteoarthritis...
January 31, 2017: Morphologie: Bulletin de L'Association des Anatomistes
https://www.readbyqxmd.com/read/28155010/chemokine-cxcl13-activates-p38-mapk-in-the-trigeminal-ganglion-after-infraorbital-nerve-injury
#19
Qian Zhang, Ming-Di Zhu, De-Li Cao, Xue-Qiang Bai, Yong-Jing Gao, Xiao-Bo Wu
Recent data demonstrated that chemokine CXCL13 mediates neuroinflammation and contributes to the maintenance of neuropathic pain after nerve injury in the spinal cord. Pro-nociceptive chemokines activate mitogen-activated protein kinases (MAPKs) which are potential signaling pathways contributing to the nociceptive behavior in inflammatory or neuropathic pain. However, whether activation of p38 and JNK MAPK signaling pathway in the trigeminal ganglion (TG) are involved in CXCL13 and its receptor CXCR5-mediated orofacial pain has not yet been clarified...
February 2, 2017: Inflammation
https://www.readbyqxmd.com/read/28151848/association-of-single-nucleotide-polymorphisms-of-cdh1-with-nonsyndromic-cleft-lip-with-or-without-cleft-palate-in-a-northern-chinese-han-population
#20
Hongquan Song, Xiaotong Wang, Jiaqun Yan, Na Mi, Xiaohui Jiao, Yanru Hao, Wei Zhang, Yuwei Gao
BACKGROUND: Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is a common congenital malformation among live births, and depends on race and ethnic background. The CDH1 gene plays a vital role in orofacial development. Our research was conducted to examine the association between 3 single-nucleotide polymorphisms in the CDH1 gene and NSCL/P. METHODS: Three single-nucleotide polymorphisms (rs16260, rs9929218, and rs1801552) of the CDH1 gene were genotyped using the Snapshot mini-sequencing technique in 331 patients with NSCL/P and 271 controls from the northern Chinese Han population...
February 2017: Medicine (Baltimore)
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