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https://www.readbyqxmd.com/read/28915898/physician-staffed-helicopter-emergency-medical-service-has-a-beneficial-impact-on-the-incidence-of-prehospital-hypoxia-and-secured-airways-on-patients-with-severe-traumatic-brain-injury
#1
Toni Pakkanen, Antti Kämäräinen, Heini Huhtala, Tom Silfvast, Jouni Nurmi, Ilkka Virkkunen, Arvi Yli-Hankala
BACKGROUND: After traumatic brain injury (TBI), hypotension, hypoxia and hypercapnia have been shown to result in secondary brain injury that can lead to increased mortality and disability. Effective prehospital assessment and treatment by emergency medical service (EMS) is considered essential for favourable outcome. The aim of this study was to evaluate the effect of a physician-staffed helicopter emergency medical service (HEMS) in the treatment of TBI patients. METHODS: This was a retrospective cohort study...
September 15, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28820595/vibronic-origin-of-the-qy-absorption-tail-of-bacteriochlorophyll-a-verified-by-fluorescence-excitation-spectroscopy-and-quantum-chemical-simulations
#2
Kristjan Leiger, Juha Matti Linnanto, Arvi Freiberg
The long-wavelength tail of the lowest-energy Qy singlet absorption band of bacteriochlorophyll a in triethylamine peaking at 768.6 nm was examined by means of fluorescence excitation spectroscopy at ambient temperature of 22 ± 1 °C. The tail, usually considered a Gaussian, does in fact weaken quasi-exponentially, being clearly evident as far as 940 nm, nearly 2400 cm(-1) (∼12 kBT) away from the absorption peak. Quantum chemical simulations identified vibronic transitions from the thermally populated normal modes and their overtones in the ground electronic state as the origin of this tail...
August 24, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28808224/off-label-use-of-crizotinib-as-a-neoadjuvant-treatment-for-a-young-patient-when-conventional-chemotherapy-gave-no-benefits-in-stage-iiia-non-small-cell-lung-cancer
#3
Delphine Dumont, Pascal Dô, Delphine Lerouge, Gaëtane Planchard, Marc Riffet, Catherine Dubos-Arvis, Serge Danhier, Radj Gervais
BACKGROUND The treatment of locally advanced non-small cell lung cancer involves a combination of chemotherapy, surgery, and radiotherapy. Each case is discussed and the best strategy is chosen individually, following international guidelines. CASE REPORT A 37-year-old man was diagnosed with locally advanced broncho-pulmonary adenocarcinoma (stage IIIA). The disease was stable after 2 cycles of cisplatin plus Navelbine used as neoadjuvant therapy. FISH analysis revealed an ALK rearrangement. The patient then received unlicensed crizotinib as second-line neoadjuvant treatment, which led to an almost complete radiological and metabolic response...
August 15, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28766520/-the-peculiarities-of-the-relationship-between-the-effector-cells-of-the-local-immune-system-in-the-broncho-vascular-barrier-of-the-breast-fed-infants-presenting-with-certain-acute-respiratory-viral-infections
#4
O D Yagmurov, S N Litus
The acute respiratory viral infections (ARVI) are ranked among the most widespread diseases affecting the children in the early infancy. They account for 60 to 85.4% of all infections recorded in the young children. AIM: The objective of the present study was to elucidate the peculiar features of the accumulation of the effector cells of the local immunity system and intercellular interplay in the broncho-vascular barrier of the breast-fed infants presenting with various ARVIs. MATERIAL AND METHODS: We undertook the analysis of 32 cases of infections caused by influenza A and B viruses and of the adenovirus infection verified by the immunofluorescence assay...
2017: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/28762087/non-small-cell-lung-cancer-nsclc-harboring-alk-translocations-clinical-characteristics-and-management-in-a-real-life-setting-a-french-retrospective-analysis-gfpc-02-14-study
#5
Jean-Bernard Auliac, Isabelle Monnet, Catherine Dubos-Arvis, Anne Marie Chiappa, Nathalie Baize, Suzana Bota, Alain Vergnenegre, Helene Doubre, Chrystele Locher, Acya Bizieux, Gilles Robinet, Christos Chouaid
BACKGROUND: Chromosomal translocations involving the anaplastic lymphoma kinase gene (ALK) are rare oncogenic events found in 3-5% of non-small-cell lung cancers (NSCLC). Limited data have been published on the management of these patients outside clinical trials. OBJECTIVE: To investigate the clinical characteristics and management of patients with NSCLC harboring ALK translocations (ALK+) in a real-life setting in France. METHODS: This multicenter, observational, retrospective study included all NSCLC patients harboring ALK translocations diagnosed in participating centers between January 2012 and December 2014...
July 31, 2017: Targeted Oncology
https://www.readbyqxmd.com/read/28718493/the-hiv-continuum-of-care-in-the-bahamas-in-2014
#6
Nikkiah Forbes, Glenise Johnson, Arvis Mortimer, Indira Martin, Morton Frankson, Kathryn Johnston, Tamara Thompson, Sharon Weissman
Objective: The HIV cascade of care describes the spectrum of engagement in HIV care from diagnosis to viral suppression (VS). The study objective was to develop a baseline HIV cascade of care for new HIV diagnoses in the Bahamas in 2014. Methods: Individuals who were newly diagnosed with HIV in 2014 and known to be alive within a year of that diagnosis were included in the cascade of care (n = 250). Individuals with one CD4 or HIV viral load (VL) measure in 2014 were considered linked to care...
December 2016: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28628017/-combined-immunotherapy-of-reconditional-chronic-non-specific-vulvovaginitis-in-immunocompromised-girls
#7
I Nesterova, S Kovaleva, G Chudilova, L Lomtatidze, V Krutova, I Aslanian, A Tulendinova, V Malinovskaya
Nonspecific chronic vulvovaginitis (CNV) is often a clinical indicator of immune deficiency, especially in young girls. The established violations of the functioning of various parts of the immune system (IS) in this pathology dictate the need to include in the complex of immunomodulatory therapy. The developed program of combined immunotherapy for immunocompromised girls allows to reduce the severity and duration of exacerbation of CNV, their frequency against the background of a significant reduction in the incidence of ARVI...
May 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28578013/paradoxical-roles-of-dual-oxidases-in-cancer-biology
#8
REVIEW
Andrew C Little, Arvis Sulovari, Karamatullah Danyal, David E Heppner, David J Seward, Albert van der Vliet
Dysregulated oxidative metabolism is a well-recognized aspect of cancer biology, and many therapeutic strategies are based on targeting cancers by altering cellular redox pathways. The NADPH oxidases (NOXes) present an important enzymatic source of biological oxidants, and the expression and activation of several NOX isoforms are frequently dysregulated in many cancers. Cell-based studies have demonstrated a role for several NOX isozymes in controlling cell proliferation and/or cell migration, further supporting a potential contributing role for NOX in promoting cancer...
September 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28458655/diabetes-and-insulin-injection-modalities-effects-on-hepatic-and-hippocampal-expression-of-11%C3%AE-hydroxysteroid-dehydrogenase-type-1-in-juvenile-diabetic-male-rats
#9
Véronica Rougeon, Marie-Pierre Moisan, Nicole Barthe, Marie-Christine Beauvieux, Jean-Christophe Helbling, Véronique Pallet, Nathalie Marissal-Arvy, Pascal Barat
BACKGROUND: Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is often encountered in diabetes, leading to several clinical complications. Our recent results showing an elevated tetrahydrocortisol/tetrahydrocorticosterone ratio in morning urine of diabetic children compared to that of controls suggest an increased nocturnal activity of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in the former. QUESTION: We hypothesized that these observations could be explained by a reduced inhibition of hepatic 11β-HSD1 activity by exogenous insulin owing to its subcutaneous (SC) administration and absence of first hepatic passage...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28438349/hydrogen-bonds-in-the-vicinity-of-the-special-pair-of-the-bacterial-reaction-center-probed-by-hydrostatic-high-pressure-absorption-spectroscopy
#10
Liina Kangur, Michael R Jones, Arvi Freiberg
Using the native bacteriochlorophyll a pigment cofactors as local probes, we investigated the response to external hydrostatic high pressure of reaction center membrane protein complexes from the photosynthetic bacterium Rhodobacter sphaeroides. Wild-type and engineered complexes were used with a varied number (0, 1 or 2) of hydrogen bonds that bind the reaction center primary donor bacteriochlorophyll cofactors to the surrounding protein scaffold. A pressure-induced breakage of hydrogen bonds was established for both detergent-purified and membrane-embedded reaction centers, but at rather different pressures: between 0...
April 7, 2017: Biophysical Chemistry
https://www.readbyqxmd.com/read/28252630/-pharmacoepidemiological-study-of-the-course-of-influenza-and-other-acute-respiratory-viral-infections-in-risk-groups
#11
V A Bulgakova, A A Poromov, A I Grekova, N Yu Pshenichnaya, E P Selkova, N I Lvov, I A Leneva, I V Shestakova, V V Maleev
AIM: To identify risk factors (RFs) for the development of bacterial complications and the prolonged course of influenza and other acute respiratory viral infections (ARVIs) among inpatients treated in Russian healthcare facilities in the post-pandemic period; to determine the clinical presentation of the disease (flu-like syndrome) in risk-group people and to evaluate the efficacy of antiviral therapy with arbidol (umifenovir). MATERIAL AND METHODS: The investigators retrospectively analyzed randomly selected medical records of inpatients with influenza and other ARVI in 88 hospitals from 50 regions of the Russian Federation: those of 3532 and 1755 patients in the 2010-2011 and 2014-2015 seasons, respectively, by applying parametric and nonparametric statistical methods...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28105538/comparison-of-non-invasive-blood-pressure-monitoring-using-modified-arterial-applanation-tonometry-with-intra-arterial-measurement
#12
Jarkko Harju, Antti Vehkaoja, Pekka Kumpulainen, Stefano Campadello, Ville Lindroos, Arvi Yli-Hankala, Niku Oksala
Intermittent non-invasive blood pressure measurement with tourniquets is slow, can cause nerve and skin damage, and interferes with other measurements. Invasive measurement cannot be safely used in all conditions. Modified arterial tonometry may be an alternative for fast and continuous measurement. Our aim was to compare arterial tonometry sensor (BPro(®)) with invasive blood pressure measurement to clarify whether it could be utilized in the postoperative setting. 28 patients who underwent elective surgery requiring arterial cannulation were analyzed...
January 19, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28029350/-erratum-to-breast-cancer-screening-on-our-way-to-the-future-bull-cancer-103-2016-753-763
#13
Suzette Delaloge, Thomas Bachelot, François-Clément Bidard, Marc Espie, Etienne Brain, Hervé Bonnefoi, Joseph Gligorov, Florence Dalenc, Anne-Claire Hardy-Bessard, David Azria, Jean-Philippe Jacquin, Jérôme Lemonnier, William Jacot, Anthony Goncalves, Charles Coutant, Gérard Ganem, Thierry Petit, Frédérique Penault-Llorca, Marc Debled, Mario Campone, Christelle Levy, Bruno Coudert, Alain Lortholary, Laurence Venat-Bouvet, Julien Grenier, Hugues Bourgeois, Bernard Asselain, Johanna Arvis, Martine Castro, Anne Tardivon, David G Cox, Patrick Arveux, Corinne Balleyguier, Fabrice André, Roman Rouzier
No abstract text is available yet for this article.
October 28, 2016: Bulletin du Cancer
https://www.readbyqxmd.com/read/28012082/assessment-of-multi-contaminant-exposure-in-a-cancer-treatment-center-a-2-year-monitoring-of-molds-mycotoxins-endotoxins-and-glucans-in-bioaerosols
#14
Natacha Heutte, Véronique André, Catherine Dubos Arvis, Valérie Bouchart, Françoise Lemarié, Patrick Legendre, Edwige Votier, Marie-Yolande Louis, Stéphane Madelaine, Virginie Séguin, Stéphanie Gente, Philippe Vérité, David Garon
Indoor air quality in health care facilities is a major public health concern, particularly for immunocompromised patients who may be exposed to microbiological contaminants such as molds, mycotoxins, endotoxins, and (1,3)-ß-D-glucans. Over 2 years, bioaerosols were collected on a monthly basis in a cancer treatment center (Centre F. Baclesse, Normandy, France), characterized from areas where there was no any particular air treatment. Results showed the complexity of mycoflora in bioaerosols with more than 100 fungal species identified...
January 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28005035/-acute-respiratory-viral-infections-topical-issues-of-diagnosis-prevention-and-treatment-in-therapeutic-practice
#15
D I Trukhan, A L Mazurov, L A Rechapova
AIM: to assess the efficacy and safety of the medication Grippferon with loratadine for the prevention of acute respiratory viral infections (ARVI) and influenza during the epidemics. MATERIAL AND METHODS: This study included 103 patients (67 men and 36 women) aged 18 to 52 years (mean age 35.3±3.2 years). During the first visit (september 2015), we collected patient history data on the average rate of ARVI and influenza for the past three years, the disease duration and its symptoms, presence of concomitant allergic pathologies (such as vasomotor rhinitis, hay fever and urticaria) and food allergies...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28005034/-treatment-for-acute-respiratory-viral-infection-and-influenza-in-daily-clinical-practice-results-of-the-multicenter-international-observational-flu-ee-study
#16
V Kh Fazylov, I G Sitnikov, E V Silina, S B Shevchenko, L N Mozhina, L L Zamyatina, G A Eganyan, L G Groppa, B M Korsantiya
PURPOSE: To study the clinical aspects of influenza and acute respiratory viral infection (ARVI) in routine clinical practice, with efficacy and safety of the antiviral therapy evaluation. SUBJECTS AND METHODS: In the large multicenter prospective observational study were enrolled 18,946 patients aged 18 to 93 years with previously determined diagnosis of influenza or ARVI from 262 outpatient sites in Russia, Armenia, Moldova and Georgia. According to study design, 3 visits were evaluated...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/27970741/long-term-outcome-of-couples-undertaking-their-first-ivf-icsi-attempt-a-french-study
#17
I Parneix, P Arvis, S Paillet, J Longin, P Lehert, C Avril, F Lesourd
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27752932/determination-of-saturation-heart-rate-and-respiratory-rate-at-forearm-using-a-nellcor%C3%A2-forehead-spo2-saturation-sensor
#18
Jarkko Harju, Antti Vehkaoja, Ville Lindroos, Pekka Kumpulainen, Sasu Liuhanen, Arvi Yli-Hankala, Niku Oksala
Alterations in arterial blood oxygen saturation, heart rate (HR), and respiratory rate (RR) are strongly associated with intra-hospital cardiac arrests and resuscitations. A wireless, easy-to-use, and comfortable method for monitoring these important clinical signs would be highly useful. We investigated whether the Nellcor™ OxiMask MAX-FAST forehead sensor could provide data for vital sign measurements when located at the distal forearm instead of its intended location at the forehead to provide improved comfortability and easy placement...
October 17, 2016: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/27699474/atlas-of-human-diseases-influenced-by-genetic-variants-with-extreme-allele-frequency-differences
#19
Arvis Sulovari, Yolanda H Chen, James J Hudziak, Dawei Li
Genetic variants with extreme allele frequency differences (EAFD) may underlie some human health disparities across populations. To identify EAFD loci, we systematically analyzed and characterized 81 million genomic variants from 2504 unrelated individuals of 26 world populations (phase III of the 1000 Genomes Project). Our analyses revealed a total of 434 genes, 15 pathways, and 18 diseases and traits influenced by EAFD variants from five continental populations. They included known EAFD genes, such as LCT (lactose tolerance), SLC24A5 (skin pigmentation), and EDAR (hair morphology)...
January 2017: Human Genetics
https://www.readbyqxmd.com/read/27676575/p2-41-also-presented-as-pd1-06-pembrolizumab-vs-docetaxel-for-previously-treated-nsclc-keynote-010-archival-vs-new-tumor%C3%A2-samples-for-pd-l1-assessment-track-immunotherapy
#20
Roy S Herbst, Paul Baas, Jose L Perez-Gracia, Enriqueta Felip, Dong-Wan Kim, Ji-Youn Han, Julian Molina, Joo-Hang Kim, Catherine Dubos Arvis, Myung-Ju Ahn, Margarita Majem, Mary Jo Fidler, Veerle Surmont, Gilberto De Castro, Marcelo Garrido, Yue Shentu, Marisa Dolled-Filhart, Ellie Im, Edward B Garon
No abstract text is available yet for this article.
October 2016: Journal of Thoracic Oncology
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