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https://www.readbyqxmd.com/read/28636238/segmental-domain-selective-perdeuteration-and-small-angle-neutron-scattering-for-structural-analysis-of-multi-domain-proteins
#1
Miriam Sonntag, Pravin Jagtap, Bernd Simon, Marie-Sousai Appavou, Arie Geerlof, Ralf Stehle, Frank Gabel, Janosch Hennig, Michael Sattler
Multi-domain proteins play critical roles in fine-tuning essential processes in cellular signaling and gene regulation. Typically, multiple globular domains that are connected by flexible linkers undergo dynamic re-arrangements upon binding to protein, DNA or RNA ligands. RNA binding proteins (RBPs) represent an important class of multi-domain proteins, which regulate gene expression by recognizing linear or structured RNA sequence motifs. Here, we employ segmental perdeuteration of the three RNA recognition motif (RRM) domains in the RBP TIA-1 using Sortase A-mediated protein ligation...
June 21, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28634546/low-hemoglobin-among-pregnant-women-in-midwives-practice-of-primary-health-care-jatinangor-indonesia-iron-deficiency-anemia-or-%C3%AE-thalassemia-trait
#2
Ari Indra Susanti, Edhyana Sahiratmadja, Gatot Winarno, Adhi Kristianto Sugianli, Herman Susanto, Ramdan Panigoro
Low hemoglobin (Hb) or anemia is common among pregnant women in developing countries which may cause adverse pregnancy outcomes and maternal deaths. Our study aimed to assess Hb level measured by midwives in primary health care facility at rural area of Jatinangor, Indonesia, and to explore whether the anemia was due to iron deficiency (IDA) or β-thalassemia trait (β-TT). Pregnant women (n = 105) had finger prick test for Hb level during a regular antenatal care examination from October to November 2016. Hb level by finger prick test was compared with venous blood, measured by complete blood count (CBC)...
2017: Anemia
https://www.readbyqxmd.com/read/28633636/typology-of-birth-centres-in-the-netherlands-using-the-rainbow-model-of-integrated-care-results-of-the-dutch-birth-centre-study
#3
Inge C Boesveld, Marc A Bruijnzeels, Marit Hitzert, Marieke A A Hermus, Karin M van der Pal-de Bruin, M Elske van den Akker-van Marle, Eric A P Steegers, Arie Franx, Raymond G de Vries, Therese A Wiegers
BACKGROUND: The goal of integrated care is to offer a continuum of care that crosses the boundaries of public health, primary, secondary, and tertiary care. Integrated care is increasingly promoted for people with complex needs and has also recently been promoted in maternity care systems to improve the quality of care. Especially when located near an obstetric unit, birth centres are considered to be ideal settings for the realization of integrated care. At present, however, we know very little about the degree of integration in these centres and we do not know if increased levels of integration improve the quality of the care delivered...
June 21, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28633580/platinum-agents-and-mitomycin-c-specific-complications-in-cytoreductive-surgery-crs-and-hyperthermic-intraperitoneal-chemotherapy-hipec
#4
Grace Hwei Ching Tan, Nicholas B Shannon, Claramae Shulyn Chia, Khee Chee Soo, Melissa Ching Ching Teo
INTRODUCTION: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have been found to prolong survival in patients with peritoneal disease but is associated with significant morbidity. We evaluate the perioperative complications and the association with the chemotherapy agent used for HIPEC. METHODS: Retrospective analysis of a prospectively collected database of CRS-HIPEC cases between April 2001 and February 2016 was performed. Patients were stratified by the chemotherapy used, and perioperative complications were compared...
June 20, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28633185/erratum-the-prevalence-of-cruciate-ligament-and-meniscus-knee-injury-in-young-adults-and-associations-with-gender-body-mass-index-and-height-a-large-cross-sectional-study
#5
Ran Thein, Oded Hershkovich, Barak Gordon, Gideon Burstein, Shay Tenenbaum, Estela Derazne, Dorit Tzur, Ari Shamis, Arnon Afek, Yitshak Kreiss
No abstract text is available yet for this article.
June 20, 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/28632238/attitudes-among-nurses-toward-the-integration-of-complementary-medicine-into-supportive-cancer-care
#6
Eran Ben-Arye, Bella Shulman, Yael Eilon, Rachel Woitiz, Victoria Cherniak, Ilanit Shalom Sharabi, Osnat Sher, Hiba Reches, Yfat Katz, Michal Arad, Elad Schiff, Noah Samuels, Ofer Caspi, Shahar Lev-Ari, Moshe Frenkel, Abed Agbarya, Hana Admi
PURPOSE/OBJECTIVES: To explore the attitudes of nurses treating patients with cancer regarding the use of complementary and integrative medicine (CIM) therapies to reduce symptoms and improve quality of life (QOL). 
. DESIGN: Prospective and descriptive.
 
. SETTING: 12 hospital and community care settings in Israel. 
. SAMPLE: 973 nurses working in oncology and non-oncology departments.
. METHODS: A 26-item questionnaire was administered to a convenience sample of nurses treating patients with cancer...
July 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28631269/missing-hla-c-group-1-ligand-in-patients-with-aml-and-mds-is-associated-with-reduced-risk-of-relapse-and-better-survival-after-allogeneic-stem-cell-transplantation-with-fludarabine-and-treosulfan-reduced-toxicity-conditioning
#7
Avichai Shimoni, Luca Vago, Massimo Bernardi, Ronit Yerushalmi, Jacopo Peccatori, Raffaella Greco, Noga Shem-Tov, Alessandro Lo Russo, Ivetta Danylesko, Arie Apel, Chiara Bonini, Maria Teresa Lupo Stanghellini, Arnon Nagler, Fabio Ciceri
Reduced-toxicity conditioning with fludarabine and treosulfan is a dose-intensive regimen with enhanced anti-leukemia effect and acceptable toxicity in AML/MDS. HLA-C regulates natural-killer (NK) cell function by inhibiting Killer immunoglobulin-like receptors (KIR) and is divided into C1 and C2 epitopes. The missing-ligand theory suggests that missing recipient KIR ligands drives NK-alloreactivity after SCT, in the absence of HLA-mismatch by activating unlicensed donor NK cells. We analyzed SCT outcomes in 203 patients with AML/MDS, median age 58 years, given SCT from matched-siblings (n=97) or matched-unrelated donors (n=106), using two treosulfan doses (total 36 or 42 gr/m2)...
June 19, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28630429/marine-diatoms-change-their-gene-expression-profile-when-exposed-to-microscale-turbulence-under-nutrient-replete-conditions
#8
Alberto Amato, Gianluca Dell'Aquila, Francesco Musacchia, Rossella Annunziata, Ari Ugarte, Nicolas Maillet, Alessandra Carbone, Maurizio Ribera d'Alcalà, Remo Sanges, Daniele Iudicone, Maria I Ferrante
Diatoms are a fundamental microalgal phylum that thrives in turbulent environments. Despite several experimental and numerical studies, if and how diatoms may profit from turbulence is still an open question. One of the leading arguments is that turbulence favours nutrient uptake. Morphological features, such as the absence of flagella, the presence of a rigid exoskeleton and the micrometre size would support the possible passive but beneficial role of turbulence on diatoms. We demonstrate that in fact diatoms actively respond to turbulence in non-limiting nutrient conditions...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28629737/the-obligatory-role-of-activin-a-in-the-formation-of-heterotopic-bone-in-fibrodysplasia-ossificans-progressiva
#9
Dana M Alessi Wolken, Vincent Idone, Sarah J Hatsell, Paul B Yu, Aris N Economides
Fibrodysplasia Ossificans Progressiva (FOP) is a rare genetic disorder that presents at birth with only minor patterning defects, but manifests its debilitating pathology early in life with episodic, yet progressive and cumulative, heterotopic ossification (HO) of ligaments, tendons, and a subset of major skeletal muscles. The resulting HO lesions are endochondral in nature, and appear to be linked to inflammatory stimuli arising in association with known injuries, or from inflammation linked to normal tissue repair...
June 16, 2017: Bone
https://www.readbyqxmd.com/read/28627494/first-record-of-proliferative-kidney-disease-agent-tetracapsuloides-bryosalmonae-in-wild-brown-trout-and-european-grayling-in-finland
#10
Anti Vasemägi, Ilkka Nousiainen, Ari Saura, Juha-Pekka Vähä, Jorma Valjus, Ari Huusko
The myxozoan endoparasite Tetracapsuloides bryosalmonae causes temperature-driven proliferative kidney disease (PKD) in salmonid fishes. Despite the economic and ecological importance of PKD, information about the distribution of the parasite is still scarce. Here, we report for the first time the occurrence of T. bryosalmonae in wild brown trout Salmo trutta and European grayling Thymallus thymallus populations in Finland. We detected T. bryosalmonae at high prevalence in both brown trout and European grayling from the transboundary Finnish-Russian River Koutajoki system (Rivers Oulankajoki, Kuusinkijoki, Kitkajoki, Maaninkajoki, and Juumajoki) in north-eastern Finland...
June 19, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/28626862/acoustic-field-characterization-of-a-clinical-magnetic-resonance-guided-high-intensity-focused-ultrasound-system-inside-the-magnet-bore
#11
Satya V V N Kothapalli, Michael B Altman, Ari Partanen, Leighton Wan, H Michael Gach, William Straube, Dennis E Hallahan, Hong Chen
PURPOSE: With the expanding clinical application of magnetic resonance-guided high intensity focused ultrasound (MR-HIFU), acoustic field characterization of MR-HIFU systems is needed for facilitating regulatory approval and ensuring consistent and safe power output of HIFU transducers. However, the established acoustic field measurement techniques typically use equipment that cannot be used in a magnetic resonance imaging (MRI) suite, thus posing a challenge to the development and execution of HIFU acoustic field characterization techniques...
June 19, 2017: Medical Physics
https://www.readbyqxmd.com/read/28625767/early-life-stress-perturbs-the-function-of-microglia-in-the-developing-rodent-brain-new-insights-and-future-challenges
#12
REVIEW
Frances K Johnson, Arie Kaffman
The role of the innate immune system in mediating some of the consequences of childhood abuse and neglect has received increasing attention in recent years. Most of the work to date has focused on the role that neuroinflammation plays in the long-term adult psychiatric and medical complications associated with childhood maltreatment. The effects of stress-induced neuroinflammation on neurodevelopment have received little attention because until recently this issue has not been studied systematically in animal models of early life stress...
June 15, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28625714/proteomic-analysis-of-seminal-plasma-from-locally-adapted-curraleiro-p%C3%A3-duro-bulls-bos-taurus-identifying-biomarkers-involved-in-sperm-physiology-in-endangered-animals-for-conservation-of-biodiversity
#13
E B Menezes, R V de Oliveira, M F van Tilburg, E A Barbosa, N V Nascimento, A L M C S Velho, F B Moreno, R A Moreira, A C O Monteiro-Moreira, G M C Carvalho, A F Ramos, E Memili, A A Moura
The present study was aimed at evaluating the seminal plasma proteins and sperm parameters of Curraleiro Pé-Duro bulls. Semen was collected from 10 bulls by electroejaculation, and sperm parameters were evaluated in fresh and frozen-thawed semen. Seminal plasma proteins were analyzed by 2-D SDS-PAGE and mass spectrophotometry. Tools in computational biology were used to generate bioinformatic knowledge and evaluate gene ontology, protein-protein interactions, phylogenetic trees and multiple sequence alignments...
May 29, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28625685/objective-quantification-of-anterior-chamber-inflammation-measuring-cells-and-flare-by-anterior-segment-optical-coherence-tomography
#14
Alessandro Invernizzi, Sylvia Marchi, Raffaella Aldigeri, Valentina Mastrofilippo, Fabiana Viscogliosi, Annamaria Soldani, Chantal Adani, Elena Garoli, Francesco Viola, Luigi Fontana, Peter McCluskey, Luca Cimino
PURPOSE: To assess the ability of swept-source (SS) optical coherence tomography (OCT) of the anterior segment (AS) to measure anterior chamber (AC) inflammation (both flare and cells) objectively. To compare OCT-derived inflammatory indices with standard techniques. DESIGN: Prospective evaluation of a diagnostic test. PARTICIPANTS: Patients diagnosed with anterior uveitis (active or inactive) and controls. METHODS: Participants underwent an AC inflammation evaluation including: clinical cell and flare grading and laser flare photometry (LFP)...
June 16, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28624975/deleterious-acute-and-chronic-effects-of-bradycardic-right-ventricular-apex-pacing-consequences-for-arrhythmic-outcome
#15
T R G Stams, A Dunnink, W M van Everdingen, H D M Beekman, R van der Nagel, B Kok, M F A Bierhuizen, M J Cramer, M Meine, M A Vos
In the chronic complete atrioventricular (AV) block dog (CAVB) model, both bradycardia and altered ventricular activation due to the uncontrolled idioventricular rhythm contribute to ventricular remodeling and the enhanced susceptibility to Torsade de Pointes (TdP) arrhythmias. We investigated the effect of permanent bradycardic right ventricular apex (RVA) pacing on mechanical and electrical remodeling and TdP. In 23 anesthetized dogs, serial experiments were performed at sinus rhythm (SR), acutely after AV block (AAVB) and 3 weeks of remodeling CAVB at a fixed pacing rate of 60/min...
July 2017: Basic Research in Cardiology
https://www.readbyqxmd.com/read/28624874/reliable-molecular-differentiation-of-trichuris-ovis-and-trichuris-discolor-from-sheep-ovis-orientalis-aries-and-roe-deer-capreolus-capreolus-and-morphological-characterisation-of-their-females-morphology-does-not-work-sufficiently
#16
Pavel Vejl, Stanislava Nechybová, Pavla Peřinková, Martina Melounová, Vladimíra Sedláková, Jakub Vašek, Daniela Čílová, Kateřina Rylková, Ivana Jankovská, Jaroslav Vadlejch, Iva Langrová
The main aim of the study was to evaluate associations between morphological variability of Trichuris females from sheep and roe deer and their rDNA polymorphism in whipworm populations from the Czech Republic. The results introduced the use of new molecular markers based on the internal transcribed spacer (ITS)1-5.8S RNA-ITS2 region polymorphisms, as useful tools for the unambiguous differentiation of congeners Trichuris ovis and Trichuris discolor. These markers revealed both parasites in roe deer and in sheep; however, T...
June 17, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28623716/aldose-reductase-inhibitors-attenuate-%C3%AE-amyloid-induced-tnf-%C3%AE-production-in-microlgia-via-ros-pkc-mediated-nf-%C3%AE%C2%BAb-and-mapk-pathways
#17
Xiao-Min Song, Qian Yu, Xin Dong, Hyun Ok Yang, Ke-Wu Zeng, Jun Li, Peng-Fei Tu
Microglia-mediated neuroinflammation is a key risk factor to the development of Alzheimer' disease (AD). Aldose reductase (AR) has been found to be widely involved in inflammation-related diseases; however, whether aldose reductase inhibitors (ARIs) could be used to treat neuroinflammation is rarely reported. This study aims to evaluate the anti-neuroinflammatory effects of two major ARIs of Sorbinil (Sor) and Zopolrestat (Zol) in β-amyloid protein (Aβ)-induced microglia (BV-2). We find that Sor and Zol significantly inhibit TNF-α, IL-1β, IL-6 production from microglia in response to Aβ stimulation...
June 14, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28621969/statistics-of-fractionalized-excitations-through-threshold-spectroscopy
#18
Siddhardh C Morampudi, Ari M Turner, Frank Pollmann, Frank Wilczek
We show that neutral anyonic excitations have a signature in spectroscopic measurements of materials: The low-energy onset of spectral functions near the threshold follows universal power laws with an exponent that depends only on the statistics of the anyons. This provides a route, using experimental techniques such as neutron scattering and tunneling spectroscopy, for detecting anyonic statistics in topologically ordered states such as gapped quantum spin liquids and hypothesized fractional Chern insulators...
June 2, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28620767/a-novel-method-for-mouse-retinal-temperature-determination-based-on-erg-photoresponses
#19
Marja Pitkänen, Ossi Kaikkonen, Ari Koskelainen
This study introduces a novel retinal temperature determination method based on the temperature dependent properties of photoresponses recorded by electroretinography (ERG). The kinetics and amplitudes of ERG photoresponses depend on retinal temperature. Additionally, raising retinal temperature increases the probability of long-wavelength photon absorption, which manifests as temperature dependence of photoreceptor sensitivity. In this study we extract a number of features that represent these properties from the a- and b-waves of mouse ex vivo ERG flash responses and construct three multivariable regression models between temperature and the selected features...
June 15, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28620490/ketogenic-diet-predictors-of-seizure-control
#20
Nitin Agarwal, Dimitrios Arkilo, Osman Farooq, Cynthia Gillogly, Katelyn S Kavak, Arie Weinstock
BACKGROUND: The ketogenic diet is an effective non-pharmacologic treatment for medically resistant epilepsy. The aim of this study was to identify any predictors that may influence the response of ketogenic diet. METHODS: A retrospective chart review for all patients with medically resistant epilepsy was performed at a tertiary care epilepsy center from 1996 to 2012. Patient- and diet-related variables were evaluated with respect to seizure reduction at 1, 3, 6, 9 and 12-month intervals and divided into four possible outcome classes...
2017: SAGE Open Medicine
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