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https://www.readbyqxmd.com/read/29351450/cardiac-vanilloid-receptor-1-afferent-depletion-enhances-stellate-ganglion-neuronal-activity-and-efferent-sympathetic-response-to-cardiac-stress
#1
Koji Yoshie, Pradeep S Rajendran, Louis Massoud, OhJin Kwon, Vasudev Tadimeti, Siamak Salavatian, Jeffrey Laurence Ardell, Kalyanam Shivkumar, Olujimi A Ajijola
Afferent fibers expressing the vanilloid receptor 1 (VR1) channel are implicated in cardiac nociception, however, their role in modulating reflex responses to cardiac stress is not well-understood. We evaluated this role in Yorkshire pigs by percutaneous epicardial application of resiniferatoxin (RTX), a toxic activator of the VR1 channel, resulting in depletion of cardiac VR1-expressing afferents. Hemodynamics, epicardial activation recovery intervals (ARIs), and in vivo activity of stellate ganglion (SG) neurons (SGNs) were recorded in control and RTX-treated animals...
January 16, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29351323/fire-forbids-fifty-fifty-forest
#2
Egbert H van Nes, Arie Staal, Stijn Hantson, Milena Holmgren, Salvador Pueyo, Rafael E Bernardi, Bernardo M Flores, Chi Xu, Marten Scheffer
Recent studies have interpreted patterns of remotely sensed tree cover as evidence that forest with intermediate tree cover might be unstable in the tropics, as it will tip into either a closed forest or a more open savanna state. Here we show that across all continents the frequency of wildfires rises sharply as tree cover falls below ~40%. Using a simple empirical model, we hypothesize that the steepness of this pattern causes intermediate tree cover (30‒60%) to be unstable for a broad range of assumptions on tree growth and fire-driven mortality...
2018: PloS One
https://www.readbyqxmd.com/read/29351184/cleft-palate-repair-does-hospital-case-volume-impact-outcomes-or-cost
#3
Ari M Wes, Daniel Mazzaferro, Sanjay Naran, Scott P Bartlett, Jesse A Taylor
BACKGROUND: How hospital case-volume affects operative outcomes and cost continues to grow in importance. The purpose of this study is to examine the relationship of case volume with operative outcomes and cost in cleft palate repair. METHODS: Subjects undergoing cleft palate repair between 2004 and 2015 were identified in the Pediatric Health Information System (PHIS). Outcomes were compared between two exposure groups, those undergoing treatment at a high-volume institution (>85th percentile; >60 cases per year), and those undergoing treatment at a low-volume institution...
January 12, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29350791/comparison-of-outpatient-medically-attended-and-community-level-influenza-like-illness-new-york-city-2013-2015
#4
Kate E Russell, Ashley Fowlkes, Melissa S Stockwell, Celibell Y Vargas, Lisa Saiman, Elaine L Larson, Philip LaRussa, Steve Di Lonardo, Michael Popowich, Kirsten St George, Andrea Steffens, Carrie Reed
BACKGROUND: Surveillance of influenza-like illness (ILI) in the United States is primarily conducted through medical settings despite a significant burden of non-medically attended ILI. OBJECTIVES: To assess consistency between surveillance for respiratory viruses in outpatient and community settings using ILI surveillance from the Centers for Disease Control and Prevention Influenza Incidence Surveillance Project (IISP) and the Mobile Surveillance for Acute Respiratory Infections (ARI) and Influenza-Like Illness in the Community (MoSAIC) Study...
January 19, 2018: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29349709/the-host-response-in-critically-ill-sepsis-patients-on-statin-therapy-a-prospective-observational-study
#5
Maryse A Wiewel, Brendon P Scicluna, Lonneke A van Vught, Arie J Hoogendijk, Aeilko H Zwinderman, René Lutter, Janneke Horn, Olaf L Cremer, Marc J Bonten, Marcus J Schultz, Tom van der Poll
BACKGROUND: Statins can exert pleiotropic anti-inflammatory, vascular protective and anticoagulant effects, which in theory could improve the dysregulated host response during sepsis. We aimed to determine the association between prior statin use and host response characteristics in critically ill patients with sepsis. METHODS: We performed a prospective observational study in 1060 patients admitted with sepsis to the mixed intensive care units (ICUs) of two hospitals in the Netherlands between January 2011 and July 2013...
January 18, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29349553/differential-jnk-p38-and-erk-response-to-renal-injury-in-a-rat-model-of-acute-pancreatitis-in-pregnancy
#6
Fangchao Mei, Teng Zuo, Liang Zhao, Qiao Shi, Mingwei Xiang, Yupu Hong, Man Li, Weixing Wang
OBJECTIVE: The objective of this study was to determine the mechanism of acute renal injury (ARI) in acute necrotizing pancreatitis in late pregnancy (ANPIP). METHODS: Pregnant Sprague-Dawley rats in the third trimester were used for this study, and an ANPIP model was induced by injecting 5% sodium taurocholate into the biliary pancreatic duct. The rats were randomly divided into three groups: the normal, sham-operated (SO) and acute necrotizing pancreatitis (ANP) groups...
January 18, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29349427/an-unusual-cause-of-cruralgia
#7
Mathieu Martin, Arié Attias, Maxime Raux, Eric Allaire, Fabrice Cook, Gilles Dhonneur
No abstract text is available yet for this article.
December 2017: Journal of Vascular Surgery Cases and Innovative Techniques
https://www.readbyqxmd.com/read/29346901/method-of-model-reduction-and-multifidelity-models-for-solute-transport-in-random-layered-porous-media
#8
Zhijie Xu, Alexandre M Tartakovsky
This work presents a method of model reduction that leads to models with three solutions of increasing fidelity (multifidelity models) for solute transport in a bounded layered porous media with random permeability. The model generalizes the Taylor-Aris dispersion theory to stochastic transport in random layered porous media with a known velocity covariance function. In the reduced model, we represent (random) concentration in terms of its cross-sectional average and a variation function. We derive a one-dimensional stochastic advection-dispersion-type equation for the average concentration and a stochastic Poisson equation for the variation function, as well as expressions for the effective velocity and dispersion coefficient...
September 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346771/rapid-turnover-of-cortical-ncam1-regulates-synaptic-reorganization-after-peripheral-nerve-injury
#9
Hyoung-Gon Ko, Jun-Hyeok Choi, Dong Ik Park, SukJae Joshua Kang, Chae-Seok Lim, Su-Eon Sim, Jaehoon Shim, Ji-Il Kim, Siyong Kim, Tae-Hyeok Choi, Sanghyun Ye, Jaehyun Lee, Pojeong Park, Somi Kim, Jeehaeh Do, Jihye Park, Md Ariful Islam, Hyun Jeong Kim, Christoph W Turck, Graham L Collingridge, Min Zhuo, Bong-Kiun Kaang
Peripheral nerve injury can induce pathological conditions that lead to persistent sensitized nociception. Although there is evidence that plastic changes in the cortex contribute to this process, the underlying molecular mechanisms are unclear. Here, we find that activation of the anterior cingulate cortex (ACC) induced by peripheral nerve injury increases the turnover of specific synaptic proteins in a persistent manner. We demonstrate that neural cell adhesion molecule 1 (NCAM1) is one of the molecules involved and show that it mediates spine reorganization and contributes to the behavioral sensitization...
January 16, 2018: Cell Reports
https://www.readbyqxmd.com/read/29343291/trends-in-the-performance-of-quality-indicators-for-diabetes-care-in-the-community-and-in-diabetes-related-health-status-an-israeli-ecological-study
#10
Ronit Calderon-Margalit, Michal Cohen-Dadi, Dana Opas, Dena H Jaffe, Jacob Levine, Arie Ben-Yehuda, Ora Paltiel, Orly Manor
BACKGROUND: Israel is one of the few countries that have a national program for quality assessment of community healthcare. We aimed to evaluate whether improved performance in diabetes care was associated with improved health of diabetic patients on a national level. METHODS: We conducted a nationwide ecological study estimating improvements in diabetes-related quality indicators and health outcomes. We estimated both correlations between composite measures of diabetes-related quality indicators and selected outcomes, and assessed through a joinpoint analysis whether trends in selected outcomes changed 4 years after the inception of the national program...
January 17, 2018: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/29341954/carbapenemase-production-of-clinical-isolates-acinetobacter-baumannii-and-pseudomonas-aeruginosa-from-a-bulgarian-university-hospital
#11
Atanaska P Petrova, Irina D Stanimirova, Ivan N Ivanov, Michael M Petrov, Tsonka M Miteva-Katrandzhieva, Vasil I Grivnev, Velichka S Kardjeva, Todor V Kantardzhiev, Mariana A Murdjeva
BACKGROUND: Production of Bla OXA-23, OXA-24, OXA-58 and hyperexpression of OXA-51 due to ISAba1 insertion sequence are the leading causes of carbapenem resistance in Acinetobacter baumannii. The loss of OprD transmembrane protein and the overexpression of some effl ux pumps are considered to be the main factors for carbapenem resistance in Pseudomonas aeruginosa whereas metallo-enzymes' production has a secondary role. AIM: Тo examine the carbapenem resistance due to carbapenemase production among clinically signifi cant Gram-negative non-fermenters from St George University hospital, Plovdiv: A...
December 20, 2017: Folia Medica
https://www.readbyqxmd.com/read/29341735/complementarity-and-polarization-modulation-in-photon-interference
#12
Andreas Norrman, Kasimir Blomstedt, Tero Setälä, Ari T Friberg
We derive two general complementarity relations for the distinguishability and visibility of genuine vector-light quantum fields in double-pinhole photon interference involving polarization modulation. The established framework reveals an intrinsic aspect of wave-particle duality of the photon, not previously reported, thus providing deeper insights into foundational quantum interference physics.
July 28, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29341608/molecular-dynamics-pinpoint-the-global-fluorine-effect-in-balanoids-binding-to-pkc%C3%AE%C2%B5-and-pka
#13
Ari Hardianto, Fei Liu, Shoba Ranganathan
(-)-Balanol is an ATP mimic that inhibits protein kinase C (PKC) isozymes and cAMP-dependent protein kinase (PKA) with little selectivity. While PKA is known as a tumour promoter, PKC isozymes can be tumour promoters or suppressors. In particular, PKCε is frequently involved in tumorigenesis and a potential target for anticancer drugs. We recently reported that stereospecific fluorination of balanol yielded a balanoid with enhanced selectivity for PKCε over other PKC isozymes and PKA, although the global fluorine effect behind the selectivity enhancement is not fully understood...
January 17, 2018: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29341591/the-development-of-benzimidazole-based-clickable-probes-for-the-efficient-labeling-of-cellular-protein-arginine-deiminases-pads
#14
Venkatesh J Nemmara, Venkataraman Subramanian, Aaron Muth, Santanu Mondal, Ari J Salinger, Aaron J Maurais, Ronak Tilvawala, Eranthie Weerapana, Paul R Thompson
Citrullination is the post-translational hydrolysis of peptidyl-arginines to form peptidyl-citrulline, a reaction that is catalyzed by the protein arginine deiminases (PADs), a family of calcium-regulated enzymes. Aberrantly increased protein citrullination is associated with a slew of autoimmune diseases (e.g., rheumatoid arthritis (RA), multiple sclerosis, lupus, and ulcerative colitis) and certain cancers. Given the clear link between increased PAD activity and human disease, the PADs are therapeutically relevant targets...
January 17, 2018: ACS Chemical Biology
https://www.readbyqxmd.com/read/29339468/molecular-epidemiology-reveals-the-role-of-war-in-the-spread-of-hiv-in-ukraine
#15
Tetyana I Vasylyeva, Mariia Liulchuk, Samuel R Friedman, Iana Sazonova, Nuno R Faria, Aris Katzourakis, Nataliia Babii, Alla Scherbinska, Julien Thézé, Oliver G Pybus, Pavlo Smyrnov, Jean L Mbisa, Dimitrios Paraskevis, Angelos Hatzakis, Gkikas Magiorkinis
Ukraine has one of the largest HIV epidemics in Europe, historically driven by people who inject drugs (PWID). The epidemic showed signs of stabilization in 2012, but the recent war in eastern Ukraine may be reigniting virus spread. We investigated the movement of HIV-infected people within Ukraine before and during the conflict. We analyzed HIV-1 subtype-A pol nucleotide sequences sampled during 2012-2015 from 427 patients of 24 regional AIDS centers and used phylogeographic analysis to reconstruct virus movement among different locations in Ukraine...
January 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29338721/infectious-keratoconjunctivitis-in-semi-domesticated-eurasian-tundra-reindeer-rangifer-tarandus-tarandus-microbiological-study-of-clinically-affected-and-unaffected-animals-with-special-reference-to-cervid-herpesvirus-2
#16
Javier Sánchez Romano, Torill Mørk, Sauli Laaksonen, Erik Ågren, Ingebjørg H Nymo, Marianne Sunde, Morten Tryland
BACKGROUND: Infectious keratoconjunctivitis (IKC) is one of the most common ocular diseases in ruminants worldwide. In addition to keratitis and conjunctivitis, animals with IKC can develop uveitis, corneal ulcer, and in severe cases, blindness. The bacteria Moraxella spp. has been described as the primary causative agent of infectious bovine keratoconjunctivitis (IBK) in cattle (Bos taurus), while Chlamydia spp. and Mycoplasma conjunctivae are considered the main causative agents of IKC in sheep (Ovis aries)...
January 16, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29338717/risk-factors-for-acute-respiratory-infections-in%C3%A2-children-under-five-years-attending-the-bamenda-regional-hospital-in-cameroon
#17
Alexis A Tazinya, Gregory E Halle-Ekane, Lawrence T Mbuagbaw, Martin Abanda, Julius Atashili, Marie Therese Obama
BACKGROUND: Acute respiratory infections (ARI) are a leading cause of morbidity and mortality in under-five children worldwide. About 6.6 million children less than 5 years of age die every year in the world; 95% of them in low-income countries and one third of the total deaths is due to ARI. This study aimed at determining the proportion of acute respiratory infections and the associated risk factors in children under 5 years visiting the Bamenda Regional Hospital in Cameroon. METHODS: A cross-sectional analytic study involving 512 children under 5 years was carried out from December 2014 to February 2015...
January 16, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29338322/associations-of-mindfulness-with-depressive-symptoms-and-well-being-in-older-adults-the-moderating-role-of-neuroticism
#18
Ari J Elliot, Autumn M Gallegos, Jan A Moynihan, Benjamin P Chapman
OBJECTIVE: To investigate whether observed interactions of mindfulness with the personality trait neuroticism extend to older adults and to aspects of psychological functioning other than depressive symptoms, and whether effects of mindfulness training in this population depend on levels of neuroticism. METHOD: We performed a secondary analysis of data from a randomized controlled trial of Mindfulness-Based Stress Reduction (MBSR) for community-dwelling older adults...
January 17, 2018: Aging & Mental Health
https://www.readbyqxmd.com/read/29337847/hiv-care-continuum-disparities-among-bisexual-black-men-and-the-mediating-effect-of-psychosocial-co-morbidities
#19
M Reuel Friedman, Jordan M Sang, Leigh A Bukowski, Derrick D Matthews, Lisa A Eaton, H Fisher Raymond, Ron Stall
INTRODUCTION: Differences across the HIV care continuum between men who have sex with men and women (MSMW) and men who have sex with men only (MSMO) are emerging in recent literature but have not been comprehensively documented among Black MSM. Although MSMW have lower HIV prevalence than MSMO, they are more likely to be HIV-positive unaware and be virally unsuppressed. Explanatory factors for these differences have not previously been assessed. METHODS: Between 2014-2016, we surveyed sexually active Black MSM ≥18 years old at Black Gay Pride events in six U...
January 15, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29337812/the-authors-reply
#20
Joseph Donnelly, Peter Smielewski, David K Menon, Ari Ercole, Marcel J H Aries
No abstract text is available yet for this article.
February 2018: Critical Care Medicine
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