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Infrared Imaging

Yuanyuan Zhang, Dan Yang, Hongzhong Chen, Wei Qi Lim, Fiona Soo Zeng Phua, Guanghui An, Piaoping Yang, Yanli Zhao
In this study, a reduction-sensitive supramolecular polymeric drug delivery system was developed for combinational photothermal-chemotherapy of cancer. The multifunctional system was self-assembled by specific host-guest interactions between hydrophilic β-cyclodextrin functionalized hyaluronic acid and adamantane linked camptothecin/dye conjugate, where a near-infrared (NIR) absorbing dye IR825 was loaded. The hydrophilic hyaluronic acid shell endows the assembly with excellent colloidal stability and biocompatibility...
February 9, 2018: Biomaterials
Kaikai Du, Lu Cai, Hao Luo, Yue Lu, Jingyi Tian, Yurui Qu, Pintu Ghosh, Yanbiao Lyu, Zhiyuan Cheng, Min Qiu, Qiang Li
The ability to continuously tune the emission wavelength of mid-infrared thermal emitters while maintaining high peak emissivity remains a challenge. By incorporating the nonvolatile phase changing material Ge 2 Sb 2 Te 5 (GST), two different kinds of wavelength-tunable mid-infrared thermal emitters based on simple layered structures (GST-Al bilayer and Cr-GST-Au trilayer) are demonstrated. Aiming at high peak emissivity at a tunable wavelength, an Al film and an ultrathin (∼5 nm) top Cr film are adopted for these two structures, respectively...
February 16, 2018: Nanoscale
Syed Ahmed Shah, Muhammad Sohail, Muhammad Usman Minhas, Nisar-Ur-Rehman, Shahzeb Khan, Zahid Hussain, Mudassir, Arshad Mahmood, Mubeen Kousar, Asif Mahmood
Cellulose acetate phthalate-based pH-responsive hydrogel was synthesized for fabrication of polymeric matrix tablets for gastro-protective delivery of loxoprofen sodium. Cellulose acetate phthalate (CAP) was cross-linked with methacrylic acid (MAA) using free radical polymerization technique. Fourier transform infrared (FTIR) spectra confirmed the formation of cross-linked structure of CAP-co-poly(methacrylic acid). Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) confirmed the thermal stability of polymeric networks, and scanning electron microscopy (SEM) and energy-dispersive X-ray spectrum (EDS) images unveiled that the prepared formulations were porous in nature and thus the developed formulations had shown better diffusibility...
February 15, 2018: Drug Delivery and Translational Research
Reju George Thomas, Myeong Ju Moon, Suchithra Poilil Surendran, Hyeong Ju Park, In-Kyu Park, Byeong-Il Lee, Yong Yeon Jeong
PURPOSE: Paclitaxel (PTX) loaded hydrophobically modified glycol chitosan (HGC) micelle is biocompatible in nature, but it requires cancer targeting ability and stimuli release property for better efficiency. To improve tumor retention and drug release characteristic of HGC-PTX nanomicelles, we conjugated cancer targeting heptamethine dye, MHI-148, which acts as an optical imaging agent, targeting moiety and also trigger on-demand drug release on application of NIR 808 nm laser. PROCEDURES: The amine group of glycol chitosan modified with hydrophobic 5β-cholanic acid and the carboxyl group of MHI-148 were bonded by 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide/N-hydroxysuccinimide chemistry...
February 15, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
Tessa Buckle, Danny M van Willigen, Silvia J Spa, Albertus W Hensbergen, Steffen van der Wal, Clarize M de Korne, Mick M Welling, Henk G van der Poel, James C H Hardwick, Fijs W B van Leeuwen
Objectives: The potential of (receptor-mediated) fluorescence-based image-guided surgery tracers is generally linked to the near-infrared emission profile and good manufacturing production (GMP) availability of fluorescent dyes. Surprisingly, little is known about the critical interaction between the structural composition of the dye and the pharmacokinetics of the tracers. In this study, a bimodal/hybrid tracer design was used to systematically and quantitatively evaluate the influence of elongation of the polymethine chain in a fluorescent cyanine (Cy) dye on the imaging potential of a targeted (RGD-based) tracer...
February 15, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Matthew G Daly, Iain Melton, Graham Roper, Gary Lim, Ian G Crozier
BACKGROUND: Catheter ablation for atrial fibrillation has potential to cause esophageal thermal injury. Esophageal temperature monitoring during ablation is commonly used; however, it has not eliminated thermal injuries, possibly because conventional sensors have poor spatial sampling and response characteristics. To enhance understanding of temperature dynamics that may underlie esophageal injury, we tested a high-resolution, intrabody, infrared thermography catheter to continuously image esophageal temperatures during ablation...
February 2018: Circulation. Arrhythmia and Electrophysiology
S Serranti, A Trella, G Bonifazi, C Garcia Izquierdo
In this work the possibility to apply hyperspectral imaging as a fast and non-destructive technique for the monitoring of the production process at pilot plant scale of an innovative biowaste-derived fertilizer was explored. Different mixtures of urban organic waste, farm organic residues, biochar and vegetable active principles were selected and utilized in two different European countries, Italy and Spain, for the production of the innovative fertilizer. The biowaste-derived fertilizer samples were collected from the pilot plant piles at different curing time and acquired by the hyperspectral imaging device...
February 12, 2018: Waste Management
Parveer Kaur, Bhupendra Chudasama
Gold nanorods (GNRs) owing to their tunable longitudinal surface plasmon resonance in tissue transparent near infrared region have potential applications (like cancer imaging, surface enhanced Raman spectroscopy, cancer targeting, drug delivery and optical hyperthermia) in nanomedicine. Success of these diagnosis/therapy options depends on the plasmonic properties of gold nanorods, which are influenced by the interaction of GNRs with the colloidal medium. In this article, a systematic study is performed to evaluate the effect of colloidal medium on shelf life and stability of gold GNRs...
March 1, 2018: Journal of Nanoscience and Nanotechnology
S Suguna, S Shankar, Saravana Kumar Jaganathan, Ayyar Manikandan
Ni-doped cobalt aluminate NixCo1-xAl2O4 (x = 0.0, 0.2, 0.4, 0.6, 0.8 and 1.0) spinel nanoparticles were successfully synthesized by a simple microwave combustion method using urea as the fuel and as well as reducing agent. X-ray powder diffraction (XRD) was confirmed the formation of single phase, cubic spinel cobalt-nickel aluminate structure without any other impurities. Average crystallite sizes of the samples were found to be in the range of 18.93 nm to 21.47 nm by Scherrer's formula. Fourier transform infrared (FT-IR) spectral analysis was confirmed the corresponding functional groups of the M-O, Al-O and M-Al-O (M = Co and Ni) bonds of spinel NixCo1-xAl2O4 structure...
February 1, 2018: Journal of Nanoscience and Nanotechnology
Hualong Fu, Mengchao Cui
The β-amyloid (Aβ) plaques presented within the brain parenchyma have been widely proved to be one of the hallmarks of Alzheimer's disease (AD). According to the amyloid cascade hypothesis, the accumulation of Aβ plaques in brain is intrinsic and fundamental for disease onset, and much research about the early diagnosis of AD has based on this. A recent development in Aβ detection has focused on the mapping of the molecule events in the brain using an exquisite, noninvasive, and inexpensive optical imaging technique, which has stimulated the rapid development of Aβ-specific fluorescent probes...
February 13, 2018: Current Medicinal Chemistry
Mayeul Collot, Tkhe-Kyong Fam, Pichandi Ashokkumar, Orestis Faklaris, Thierry Galli, Lydia Danglot, Andrey S Klymchenko
Lipid droplets (LDs) are intracellular lipid-rich organelles that regulate the storage of neutral lipids and were recently found to be involved in many physiological processes, metabolic disorders as well as diseases including obesity, diabetes and cancers. Herein we present a family of new fluorogenic merocyanine fluorophores based on an indolenine moiety and a dioxaborine barbiturate derivative. These so-called StatoMerocyanines (SMCy) span their fluorescence from yellow to the near infrared (NIR) in oil with an impressive fluorescence enhancement compared to aqueous media...
February 15, 2018: Journal of the American Chemical Society
Shoujun Zhu, Sonia Herraiz, Jingying Yue, Mingxi Zhang, Hao Wan, Qinglai Yang, Zhuoran Ma, Yan Wang, Jiahuan He, Alexander L Antaris, Yeteng Zhong, Shuo Diao, Yi Feng, Ying Zhou, Kuai Yu, Guosong Hong, Yongye Liang, Aaron J Hsueh, Hongjie Dai
Greatly reduced scattering in the second near-infrared (NIR-II) region (1000-1700 nm) opens up many new exciting avenues of bioimaging research, yet NIR-II fluorescence imaging is mostly implemented by using nontargeted fluorophores or wide-field imaging setups, limiting the signal-to-background ratio and imaging penetration depth due to poor specific binding and out-of-focus signals. A newly developed high-performance NIR-II bioconjugate enables targeted imaging of a specific organ in the living body with high quality...
February 15, 2018: Advanced Materials
Shigeko Yashiro, Takeshi Nishijima, Yuuka Yamamoto, Yumi Sekine, Natsuyo Yoshida-Hata, Tomohiro Iida, Shinichi Oka
PURPOSE: To assess the usefulness of spectral domain optical coherence tomography (SD-OCT) and fundus autofluorescence (FAF) findings in cytomegalovirus (CMV) retinitis. STUDY DESIGN: Observational case series. METHODS: Thirteen eyes of 11 human immunodeficiency virus (HIV)-positive patients with CMV retinitis underwent full ophthalmologic examinations, SD-OCT, and 4 eyes of 4 patients underwent FAF. FAF images included short-wavelength autofluorescence (SW-AF) and near-infrared autofluorescence (IR-AF)...
February 14, 2018: Japanese Journal of Ophthalmology
Elisa Meacci, Dania Nachira, Maria Teresa Congedo, Marco Chiappetta, Leonardo Petracca Ciavarella, Stefano Margaritora
In the era of lung cancer screening and early detection of lung lesions, pulmonary segmentectomy has gained wide acceptance between thoracic community reducing the need of lobectomy for diagnostic purpose and treatment in case of centrally located benign, multiple or undetermined lesions. In rigorously selected patients with stage I non-small cell lung cancer (NSCLC), segmentectomies seem to offer similar survival outcomes rather than lobectomies, but associated with a better conservation of lung function. However, segmentectomy is a more challenging procedure to be performed compared to lobectomy, especially by video-assisted thoracic surgery (VATS)...
2018: Journal of Visualized Surgery
Kensaku Nishihira, Fumiyuki Otsuka, Yu Kataoka, Yasuhide Asaumi, Kohei Kaneta, Hiroki Nakano, Keiko Ohta-Ogo, Hatsue Ishibashi-Ueda, Teruo Noguchi, Satoshi Yasuda
No abstract text is available yet for this article.
February 2018: Circulation. Cardiovascular Interventions
Daniel Sousa, Christopher Small
Planned hyperspectral satellite missions and the decreased revisit time of multispectral imaging offer the potential for data fusion to leverage both the spectral resolution of hyperspectral sensors and the temporal resolution of multispectral constellations. Hyperspectral imagery can also be used to better understand fundamental properties of multispectral data. In this analysis, we use five flight lines from the Airborne Visible/Infrared Imaging Spectrometer (AVIRIS) archive with coincident Landsat 8 acquisitions over a spectrally diverse region of California to address the following questions: (1) How much of the spectral dimensionality of hyperspectral data is captured in multispectral data?; (2) Is the characteristic pyramidal structure of the multispectral feature space also present in the low order dimensions of the hyperspectral feature space at comparable spatial scales?; (3) How much variability in rock and soil substrate endmembers (EMs) present in hyperspectral data is captured by multispectral sensors? We find nearly identical partitions of variance, low-order feature space topologies, and EM spectra for hyperspectral and multispectral image composites...
February 14, 2018: Sensors
Hao He, Christopher B Howard, Yinghui Chen, Shihui Wen, Gungun Lin, Jiajia Zhou, Kristofer James Thurecht, Dayong Jin
Upconversion nanoparticles (UCNPs) are new optical probes for biological applications. To realize specific biomolecular recognition for diagnosis and imaging, the key lies in developing a stable and easy-to-use bioconjugation method for antibody modification. Current methods are not yet satisfactory regarding conjugation time, stability, and binding efficiency. Here we report a facile and high-yield approach based on a bispecific antibody (BsAb), free of chemical reaction steps. One end of the BsAb is designed to recognize methoxy polyethylene glycol (mPEG) coated UCNPs, and the other end of the BsAb is to recognize the cancer antigen biomarker...
February 14, 2018: Analytical Chemistry
Kaja K Jasińska, Sosthène Guei
Portable neuroimaging approaches provide new advances to the study of brain function and brain development with previously inaccessible populations and in remote locations. This paper shows the development of field functional Near Infrared Spectroscopy (fNIRS) imaging to the study of child language, reading, and cognitive development in a rural village setting of Côte d'Ivoire. Innovation in methods and the development of culturally appropriate neuroimaging protocols allow a first-time look into the brain's development and children's learning outcomes in understudied environments...
February 2, 2018: Journal of Visualized Experiments: JoVE
Zhenhe Xu, Junying Lin, Yaguang Sun, Fu Ding, Hongtao Fan, Shan Shi, Qinghong Fang, Yanfeng Bi, Yu Gao
Lu2O3:RE3+ (RE3+ = Eu3+, Tb3+, Ho3+) nanoparticles have been successfully synthesized by a facile homogeneous precipitation method with subsequent sintering process. The crystal structure, morphology and luminescence properties of the as-prepared samples have been characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared (FT-IR), thermogravimetric analysis (TGA), photoluminescence (PL) and cathodoluminescence (CL) spectra. Upon ultraviolet (UV) and low-voltage electron beam excitation, Lu2O3:RE3+ (RE3+ = Eu3+, Tb3+, Ho3+) nanoparticles show strong red (Eu3+,5D0 → 7F2), green (Tb3+,5D4 → 7F5), and green (Ho3+,5S2 → 5I8) emissions...
April 1, 2018: Journal of Nanoscience and Nanotechnology
Diana Ciolacu, Georgeta Cazacu
The development of various green materials from lignin, which is most often considered as waste, is of prime interest from environmental and economic points of view. In the last years, only few studies regarding the use of lignin as a backbone component in the hydrogels have been made. The potential efficacy of lignin in hydrogels with particular emphasis on synthesis and characterization was investigated. By using steam explosion lignin from aspen wood or the corresponding epoxy-resin mixed with poly(vinyl alcohol), a series of new green hydrogels were prepared by covalent crosslinking in the presence of the epichlorohydrin...
April 1, 2018: Journal of Nanoscience and Nanotechnology
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