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Hemangiopericytoma tumor

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https://www.readbyqxmd.com/read/29736797/%C3%AE-catenin-ctnnb1-mutation-and-lef1-expression-in-sinonasal-glomangiopericytoma-sinonasal-type-hemangiopericytoma
#1
Yuka Suzuki, Shu Ichihara, Tomonori Kawasaki, Hiroyuki Yanai, Satoshi Kitagawa, Yoshie Shimoyama, Shigeo Nakamura, Masato Nakaguro
Sinonasal glomangiopericytoma (SN-GPC) is an uncommon mesenchymal tumor with myoid differentiation. Recently, mutations in exon 3 of the gene coding for β-catenin (CTNNB1) and its nuclear expression were discovered in SN-GPC. β-catenin protein is a key regulatory molecule of the canonical Wnt signaling pathway. The expression of β-catenin target proteins is not well characterized in SN-GPC. We examined three SN-GPCs by immunohistochemistry and CTNNB1 mutation analysis. All cases expressed nuclear β-catenin...
May 7, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29721348/atypical-epidural-hemangiopericytoma-presenting-with-visual-disturbance
#2
Satoshi Tsutsumi, Satoshi Adachi, Hisato Ishii, Yukimasa Yasumoto
Background: Hemangiopericytomas are a rare entity commonly presenting as subdural tumors. Case Description: A 57-year-old man presented with a progressive visual disturbance over a period of 3 weeks. Cranial computed tomography scans revealed an isodense mass at the tip of the left middle fossa, extending into the orbital apex, and accompanying bony erosions in the sphenoid ridge. On magnetic resonance imaging, the lesion appeared isointense both on T1- and T2-weighted sequences, and intensely enhanced on contrast examinations...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29709742/preoperative-assessment-of-pathological-subtypes-of-meningioma-and-solitary-fibrous-tumor-hemangiopericytoma-using-dynamic-computed-tomography-a-clinical-research-study
#3
Nobuhiko Arai, Katsuhiro Mizutani, Satoshi Takahashi, Yukina Tokuda, Takenori Akiyama, Takashi Horiguchi, Hatano Mami, Kazunari Yoshida
BACKGROUND: Solitary fibrous tumors (SFTs)/hemangiopericytomas (HPCs) are highly vascularized tumors well known for malignant, invasive, and highly vascular features. To date, several studies have reported the preoperative imaging findings of SFT/HPCs. In this study, computed tomography (CT) tumor values acquired from dynamic CT were selected to determine the tumor pathology of highly vascular tumors, such as SFT/HPCs. METHODS: We conducted a retrospective study on patients with pathologically diagnosed meningiomas and SFT/HPCs who had undergone a dynamic contrast CT...
April 27, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29707475/liquid-biopsy-in-rare-cancers-lessons-from-hemangiopericytoma
#4
Chiara Nicolazzo, Luciano Colangelo, Alessandro Corsi, Guido Carpino, Angela Gradilone, Chiara Sonato, Cristina Raimondi, Eugenio Gaudio, Paola Gazzaniga, Walter Gianni
Hemangiopericytoma (HPT) is a rare mesenchymal tumor of fibroblastic type and for its rarity is poorly studied. The most common sites of metastatic disease in patients with intracranial HPT are the bone, liver, and lung, suggestive for an hematogenous dissemination; for this reason, we investigated, for the first time, the presence of circulating tumor cells (CTCs) in hemangiopericytoma patient by CellSearch® and SceenCell® devices. Peripheral blood samples were drawn and processed by CellSearch, an EpCAM-dependent device, and ScreenCell®, a device size based...
2018: Analytical Cellular Pathology (Amsterdam)
https://www.readbyqxmd.com/read/29707472/bilateral-supratentorial-subdural-hematomas-after-craniotomy-for-posterior-fossa-tumor-removal
#5
Aikaterini Solomou, Pantelis Kraniotis, George Bonanos, Constantine Constantoyannis
A 69-year-old man was admitted to the emergency department with headache and dizziness. He was submitted to brain computed tomography (CT) which showed a tumor in the right cerebellar hemisphere, findings which were subsequently confirmed with magnetic resonance imaging (MRI). He underwent a paramedian suboccipital craniotomy for removal of the mass. Histology confirmed the presence of a hemangiopericytoma. The patient was discharged 5 days postoperatively with improvement in his symptoms. Fifteen days later, he presented with gait difficulties...
April 2018: Journal of Neurological Surgery Reports
https://www.readbyqxmd.com/read/29700673/pazopanib-efficacy-in-recurrent-central-nervous-system-hemangiopericytomas
#6
Caroline Apra, Agusti Alentorn, Karima Mokhtari, Michel Kalamarides, Marc Sanson
INTRODUCTION: There is currently no treatment for solitary fibrous tumors/hemangiopericytomas (SFT/H) of the central nervous system recurring after multiple surgeries and radiotherapies. The NAB2-STAT6 gene fusion is the hallmark of these tumors, and upregulates Early Growth Factor, activating several growth pathways. METHODS: We treated two patients presenting pluri-recurrent meningeal SFT/H with Pazopanib, a broad-spectrum tyrosine kinase inhibitor. We analyzed the exome and RNA sequencing data of one of them and, in addition to another meningeal SFT/H, compared it to the transcriptomic profiling of 5 systemic SFT/H...
April 26, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29695573/fat-forming-solitary-fibrous-tumor-of-the-kidney-a-case-report-and-literature-review
#7
Nicolae Bacalbasa, Irina Balescu, George Jinescu, Madalina Marcu, Andreea Contolenco, Doina Pop, Dragos Dobritoiu, Olivia Ionescu, Paris Ionescu, Claudia Stoica
Fat-forming solitary fibrous tumors arising from the kidney are extremely rare, with only few cases reported so far. We report the case of a 49-year-old patient investigated for lumbar pain and diagnosed preoperatively with a large retroperitoneal tumor destroying the right kidney. The patient was submitted to surgery, the tumor being resected en bloc with right nephrectomy. The histopathological studies demonstrated the presence of a hemangiopericytoma-like tumor with adipocytary component; the immunohistochemical studies demonstrated the presence of cluster of differentiation 34 (CD34), while human melanoma black (HMB45) staining was negative...
May 2018: In Vivo
https://www.readbyqxmd.com/read/29687253/real-time-intraoperative-contrast-enhanced-ultrasound-ceus-in-vascularized-spinal-tumors-a-technical-note
#8
Giuseppe Maria Della Pepa, Pier Paolo Mattogno, Giuseppe La Rocca, Giovanni Sabatino, Alessandro Olivi, Luca Ricciardi, Filippo Maria Polli
BACKGROUNDS: Intra-operative ultrasound (ioUS), and the recently introduced contrast-enhanced ultrasound (CEUS) demonstrated to be an extremely valuable tool in oncological cerebral neurosurgery. METHODS: The authors applied ioUS/CEUS techniques to spinal oncological surgery as showed in the illustrative case of a dorsal hemangiopericytoma. RESULTS AND CONCLUSIONS: ioUS and CEUS provide real-time information that proved useful in identifying both vascular and parenchymatous tumoral patterns, anatomical relations with nervous structure, plan surgical strategy, and identify residuals...
April 23, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29682136/metastatic-cervical-paravertebral-solitary-fibrous-tumor-detected-by-fluorodeoxyglucose-positron-emission-tomography-computed-tomography
#9
Hoiwan Cheung, Courtney Lawhn-Heath, Giselle Lopez, Maya Vella, Carina Mari Aparici
Solitary fibrous tumor/hemangiopericytomas (SFT/HPC) are soft tissue tumors that can arising from the abomen, pleura, head and neck, or extremities. We report an unusual case of recurrent hemangiopericytoma in a 67-year-old female presenting with a painless and palpable mass within her right posterior neck. Eight years after initial resection of the mass, a follow-up MRI showed multiple enlarging calvarial lesions. A whole body FDG-PET/CT revealed not only hypermetabolic calvarial lesions but also numerous hypermetabolic axillary node and osseous metastases...
April 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/29682031/solitary-fibrous-tumors-of-the-orbit-and-central-nervous-system-a-case-series-analysis
#10
Marisa Brum, Hipólito Nzwalo, Edson Oliveira, Maria Rita Pelejão, Pedro Pereira, João Paulo Farias, José Pimentel
Introduction: Solitary fibrous tumor (SFT) is rarely diagnosed in clinical practice. Since its initial descriptions in the central nervous system (CNS) and the orbits, very few case reports and small case series have expanded their clinical and pathological characterization. We sought to describe a cases series of SFT from a single laboratory of neuropathology belonging to a tertiary university hospital. Methods: Retrospective clinical and histopathological description of eight cases of CNS and orbital SFT diagnosed over a 21-year period of time...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29675794/association-between-programmed-cell-death-ligand-1-expression-and-extracranial-metastasis-in-intracranial-solitary-fibrous-tumor-hemangiopericytoma
#11
Dai Kamamoto, Kentaro Ohara, Yohei Kitamura, Kazunari Yoshida, Yutaka Kawakami, Hikaru Sasaki
BACKGROUND: Intracranial solitary fibrous tumor/hemangiopericytoma (SFT/HPC) often shows extracranial metastasis, and treatment options are very limited. Immune-checkpoint molecules have not been studied well in SFT/HPCs, and their role in intracranial SFT/HPCs remains unclear. METHODS: We investigated the expression of programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), and tumor-infiltrating lymphocytes (TIL) in 16 patients of intracranial SFT/HPC by immunohistochemistry to determine if correlation with prognosis exists...
April 19, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29629229/ambiguity-in-the-dural-tail-sign-on-mri
#12
Ramesh S Doddamani, Rajesh K Meena, Dattaraj Sawarkar
Background: Meningiomas give rise to the dural tail sign (DTS) on contrast-enhanced magnetic resonance imaging (CEMRI). The presence of DTS does not always qualify for a meningioma, as it is seen in only 60-72% of cases. This sign has been described in various other lesions like lymphomas, metastasis, hemangiopericytomas, schwannomas and very rarely glioblastoma multiforme (GBM). The characteristics of dural-based GBMs are discussed here, as only eleven such cases are reported in the literature till date...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29626688/the-houdini-tumor-a-case-report-and-literature-review-of-pregnancy-associated-meningiomas
#13
Vikram Chakravarthy, Brett Kaplan, Vadim Gospodarev, Hannah Myers, Kenneth De Los Reyes, Adina Achiriloaie
BACKGROUND: Meningiomas are common intracranial neoplasms of undetermined etiology. Accelerated growth during episodes of elevated serum estrogen and progesterone have been demonstrated in pregnant patients, as exhibited by an overexpression of estrogen or progesterone upon immunohistochemical analysis. This case report and literature review describes a case of complete meningioma regression in a postpartum patient. CASE DESCRIPTION: A 23-year-old female presented at 37 weeks of pregnancy with 1-month history of fluctuating severe left-sided headaches, periodic blurry vision, nausea and vomiting...
April 4, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29600523/grading-of-meningeal-solitary-fibrous-tumors-hemangiopericytomas-analysis-of-the-prognostic-value-of-the-marseille-grading-system-in-a-cohort-of-132-patients
#14
Nicolas Macagno, Rob Vogels, Romain Appay, Carole Colin, Karima Mokhtari, Benno Küsters, Pieter Wesseling, Dominique Figarella-Branger, Uta Flucke, Corinne Bouvier
The finding that meningeal solitary fibrous tumors (SFTs) and meningeal hemangiopericytomas (HPCs) are both characterized by NAB2-STAT6 gene fusion has pushed their inclusion in the WHO 2016 Classification of tumors of the central nervous system (CNS) as different manifestations of the same entity. Given that the clinical behavior of the CNS SFT/HPC spectrum ranges from benign to malignant, it is presently unclear whether the grading criteria are still adequate. Here, we present the results of a study that analyzed the prognostic value of an updated version of the Marseille Grading System (MGS) in a retrospectively assembled cohort of 132 primary meningeal SFTs/HPCs with nuclear overexpression of STAT6...
March 30, 2018: Brain Pathology
https://www.readbyqxmd.com/read/29595682/salvage-preoperative-embolization-of-an-infratemporal-solitary-fibrous-tumor-a-case-report-with-review-of-the-literature
#15
Kabalane Yammine, Haydar A Nasser, Usama Hadi, Mohamad Ali Natout, Vicky Najjar, Claude Tayar
RATIONALE: Head and Neck Solitary fibrous tumors (SFT) are very rare. They could be misdiagnosed as hemangiopericytomas (HPC). PATIENT CONCERNS: We report a 60 y o lady presenting with sinonasal mass, causing recurrent profuse bleeding. DIAGNOSES: Hemangioperocytomas versus SFT were among the differentials, according to Radiological studies. Upon Biopsy, the diagnosis of SFT has been adopted. INTERVENTIONS: Salvage pre-operative embolization resulted in bleeding control, bridging the patient to surgery...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29566950/biphenotypic-sinonasal-sarcoma-a-series-of-six-cases-with-evaluation-of-role-of-%C3%AE-catenin-immunohistochemistry-in-differential-diagnosis
#16
Aanchal Kakkar, Madhu Rajeshwari, Pirabu Sakthivel, Mehar C Sharma, Suresh C Sharma
INTRODUCTION: Biphenotypic sinonasal sarcoma (BSNS) is a recently described mesenchymal tumor exclusive to the sinonasal region. It is a low grade sarcoma, displaying evidence of myogenic and neural differentiation. Role of β-catenin immunohistochemistry in distinguishing it from its morphological mimics is not well-established. We conducted this study to identify cases of BSNS from our archives, and to examine immunopositivity for β-catenin in them as well as in its close differential diagnosis...
April 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29555080/non-islet-cell-tumour-hypoglycaemia-nicth-about-a-series-of-6-cases
#17
Arnaud Jannin, Stéphanie Espiard, Kanza Benomar, Christine Do Cao, Bénédicte Mycinski, Henri Porte, Michèle D'Herbomez, Nicolas Penel, Marie-Christine Vantyghem
The purpose of this study was to analyse the characteristics of 6 patients managed in a university hospital between 1996 and 2016 for non-islet cell tumor hypoglycemia (NICTH), a form of hypoglycaemia due to the paraneoplastic secretion of IGF-2 or its related substances. RESULTS: Three of these 6 patients (50%), aged over 69 years, including 2 with acromegaloid phenotype, presented with a pleural solitary fibrous tumor (SFT), with median diameter 20 cm (interquartile range, 12.5-20.5) with a low median SUV (3...
March 16, 2018: Annales D'endocrinologie
https://www.readbyqxmd.com/read/29551003/surveillance-for-metastatic-hemangiopericytoma-solitary-fibrous-tumors-systematic-literature-review-on-incidence-predictors-and-diagnosis-of-extra-cranial-disease
#18
REVIEW
Tarini Ratneswaren, Florence Rosie Avila Hogg, Mathew Joseph Gallagher, Keyoumars Ashkan
BACKGROUND: Intracranial hemangiopericytomas (HPC) and solitary fibrous tumors (SFTs) (HPC-SFT) are rare vascular tumors that resemble meningioma on imaging and predominantly affect young adults. HPC-SFT have a high rate of local recurrence with well-known propensity for extracranial metastases. This provides clinical dilemmas frequently encountered in oncology: (i) How should these patients be monitored long term? (ii) Which primary tumors are more likely to metastasize? OBJECTIVES: This systematic review aims to identify the incidence, common locations and time to presentation of extra-cranial metastases of HPC-SFT...
March 17, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29530746/myopericytoma-of-the-lip-a-case-report-of-this-rare-lesion
#19
Eric Strayer, Roger Throndson, Cecilia Clement, Keith McDaniel
Myopericytomas are rare benign tumors that show a distinctive, concentric perivascular proliferation of oval to spindle-shaped myoid-appearing cells that are predominantly arranged concentrically around thin-walled vascular channels. These lesions are similar in histologic appearance to hemangiopericytomas, myofibromas, and glomus tumors. The myopericytoma is usually found in the distal extremities, but a handful of reports have shown the lesion to be present in the oral cavity. A review of the literature to date shows only 4 other reported cases of myopericytomas occurring in the lips...
February 19, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29521591/solitary-fibrous-tumor-hemangiopericytoma-treatment-results-based-on-the-2016-who-classification
#20
Kyoung Su Sung, Ju Hyung Moon, Eui Hyun Kim, Seok-Gu Kang, Se Hoon Kim, Chang-Ok Suh, Sun Ho Kim, Kyu-Sung Lee, Won Seok Chang, Jong Hee Chang
OBJECTIVE Solitary fibrous tumor/hemangiopericytoma (SFT/HPC) is a new combined entity for which a soft-tissue-type grading system, ranging from grades I to III, has been introduced in the 2016 WHO classification of tumors of the CNS. The results of the treatment of this new disease entity require evaluation. METHODS The authors retrospectively reevaluated the pathological findings and medical records of patients with SFT/HPC. This study included 60 patients (27 men and 33 women, median age 42.5 years, range 13-69 years) treated at Severance Hospital between February 1981 and February 2016...
March 9, 2018: Journal of Neurosurgery
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