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nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3)

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https://www.readbyqxmd.com/read/29769797/protective-effects-of-erigeron-breviscapus-hand-mazz-ebhm-extract-in-retinal-neurodegeneration-models
#1
Jingyuan Zhu, Li Chen, Yun Qi, Jing Feng, Li Zhu, Yujing Bai, Huijuan Wu
Purpose: To investigate the neuroprotective effects of scutellarin, an active component of the multifunctional traditional Chinese herb Erigeron breviscapus (vant.) Hand.-Mazz. (EBHM), which has been used as a neuroprotective therapy for cerebrovascular diseases. We performed the experiments using in vitro and in vivo models of retinal neurodegeneration. Methods: In the in vitro experiments, we exposed BV-2 cells to low oxygen levels in an incubator for 24 and 48 h to generate hypoxia models...
2018: Molecular Vision
https://www.readbyqxmd.com/read/29730819/artesunate-inhibits-renal-ischemia-reperfusion-mediated-remote-lung-inflammation-through-attenuating-ros-induced-activation-of-nlrp3-inflammasome
#2
Zhaohui Liu, Min Qu, Lili Yu, Panpan Song, Yulin Chang
The molecular mechanisms of acute lung injury (ALI) are closely associated with nucleotide-binding domains and leucine-rich repeat (NLR) pyrin domains containing 3 (NLRP3) inflammasome, in which alveolar macrophages (AMs) exert an essential function. Our study has been proved that artesunate (AS) inhibits ALI. Nevertheless, the inhibition actions of AS on activation of NLRP3 in renal ischemia-reperfusion (RIR)-mediated ALI remain to be further discussed. Male Sprague-Dawley rats were randomly assigned into four groups: sham + NS, sham + AS, RIR + NS, and RIR + AS...
May 5, 2018: Inflammation
https://www.readbyqxmd.com/read/29694408/vitexin-attenuates-lipopolysaccharide-induced-acute-lung-injury-by-controlling-the-nrf2-pathway
#3
Ying Lu, Ting Yu, Jingyao Liu, Lina Gu
BACKGROUND: A major feature of acute lung injury (ALI) is excessive inflammation in the lung. Vitexin is an active component from medicinal plants which has antioxidant and anti-inflammatory activities. Oxidative stress and inflammation play important roles in the pathophysiological processes in ALI. In the current study, we investigate the effect and potential mechanisms of Vitexin on lipopolysaccharide (LPS)-induced ALI. METHODS: ALI was induced by LPS intratracheal instillation in C57BL/6 wild-type mice and Nrf2 gene knocked down (Nrf2-/-) mice...
2018: PloS One
https://www.readbyqxmd.com/read/29601102/frontline-science-specialized-proresolving-lipid-mediators-inhibit-the-priming-and-activation-of-the-macrophage-nlrp3-inflammasome
#4
Aritz Lopategi, Roger Flores-Costa, Bibiana Rius, Cristina López-Vicario, José Alcaraz-Quiles, Esther Titos, Joan Clària
The prototypic proinflammatory cytokine IL-1β plays a central role in innate immunity and inflammatory disorders. The formation of mature IL-1β from an inactive pro-IL-1β precursor is produced via nonconventional multiprotein complexes called the inflammasomes, of which the most common is the nucleotide-binding domain leucine-rich repeat-containing protein 3 (NLRP3) inflammasome composed by NLRP3, (ASC) apoptosis-associated speck-like protein containing a caspase activation and recruitment domain (CARD), and caspase-1...
March 30, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29574653/effect-of-soluble-epoxide-hydrolase-in-hyperoxic-acute-lung-injury-in-mice
#5
Ping-Song Li, Wei Tao, Liu-Qing Yang, Yu-Sheng Shu
Hyperoxic acute lung injury is a serious complication of oxygen therapy that causes high mortality. Inhibition of soluble epoxide hydrolase (sEH) has been reported to have protective effect on lipopolysaccharide-induced acute lung injury (ALI). This study investigates whether sEH plays any role in the pathogenesis of hyperoxic ALI. Wild-type and sEH gene knockout (sEH-/- ) mice were exposed to 100% O2 for 72 h to induce hyperoxic ALI. Hyperoxia caused infiltration of inflammatory cells, elevation of interleukin-1β and interleukin-6 levels, and deterioration of alveolar capillary protein leak as well as wet/dry weight ratio in the lung...
March 24, 2018: Inflammation
https://www.readbyqxmd.com/read/29525626/effects-on-il-1%C3%AE-signaling-activation-induced-by-water-and-organic-extracts-of-fine-particulate-matter-pm-2-5-in-vitro
#6
Fanfan Xu, Xinghua Qiu, Xinyan Hu, Yu Shang, Michal Pardo, Yanhua Fang, Junxia Wang, Yinon Rudich, Tong Zhu
Fine particulate matter (PM2.5 ) air pollution poses a major risk to human health worldwide, and absorbed chemicals play a key role in determining the toxicity of PM2.5 . After inhalation and entry into the lungs, PM2.5 components induce pro-inflammatory cytokines (e.g., interleukin (IL)-1β) in pulmonary cells. To test whether PM2.5 components induce IL-1β through signing pathways that include the toll-like receptor 4 (TLR4)/nuclear factor-κ-gene binding (NF-κB), nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3), we exposed the mouse macrophage cell-line RAW264...
June 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29385859/the-nlrp3-rs10754558-polymorphism-is-a-risk-factor-for-preeclampsia-in-a-chinese-han-population
#7
Longqiang Xu, Sai Li, Zhen Liu, Shuting Jiang, Jingli Wang, Mingzhen Guo, Xin Zhao, Weiqing Song, Shiguo Liu
OBJECTIVE: Previous studies have indicated that the nucleotide-binding domain, leucine-rich repeat containing protein 3 (NLRP3) inflammasome is activated by monosodium urate in the trophoblast of preeclampsia (PE) patients, leading to augmented placental IL-1β levels. Thus, the purpose of our study was to investigate the association between NLRP3 polymorphisms, rs10754558 and rs2027432, and PE in Chinese Han population. METHODS: The NLRP3 polymorphisms, rs10754558 and rs2027432, were genotyped by real-time PCR in 1024 PE patients and 1194 control subjects...
January 31, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29383704/platelets-at-the-crossroads-of-thrombosis-inflammation-and-haemolysis
#8
Sebastian Vogel, Swee Lay Thein
Platelets play a critical role at the interphase of thrombosis and inflammation, key features in haemolysis-associated disorders. Exercising this role requires expression of pattern recognition receptors by platelets, including toll-like receptor 4 (TLR4) and nucleotide-binding domain leucine rich repeat containing protein 3 (NLRP3), the latter forming intraplatelet multiprotein inflammasome complexes. Platelets are a potential target of various damage-associated molecular pattern (DAMP) molecules, such as free haem, a degradation by-product of haemoglobin oxidation during haemolysis, and high-mobility group box 1 (HMGB1), a DNA-binding protein released by dying or stressed cells and activated platelets...
March 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29374549/matrine-suppresses-age-induced-haec-injury-by-inhibiting-ros-mediated-nrlp3-inflammasome-activation
#9
Yong Zhang, Xiaoqiang Yang, Chuan Qiu, Fei Liu, Peng Liu, Zhongwei Liu
Diabetes is characterized by a high level of advanced glycation end products (AGEs), which induce damage in the arterial endothelium. Matrine has been shown to have cardioprotective effects. This study's aim was to investigate the protective effects and possible molecular mechanisms of matrine in AGE-induced human aortic endothelial cell (HAEC) injury. Cultured HAECs were treated with AGEs and/or serially diluted matrine. Cell viability was evaluated by MTT assay. Intracellular reactive oxygen species production was determined by flow cytometry...
March 5, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29321274/irf1-is-a-transcriptional-regulator-of-zbp1-promoting-nlrp3-inflammasome-activation-and-cell-death-during-influenza-virus-infection
#10
Teneema Kuriakose, Min Zheng, Geoffrey Neale, Thirumala-Devi Kanneganti
Innate immune sensing of influenza A virus (IAV) induces activation of various immune effector mechanisms, including the nucleotide and oligomerization domain, leucine-rich repeat-containing protein family, pyrin domain containing 3 (NLRP3) inflammasome and programmed cell death pathways. Although type I IFNs are identified as key mediators of inflammatory and cell death responses during IAV infection, the involvement of various IFN-regulated effectors in facilitating these responses are less studied. In this study, we demonstrate the role of IFN regulatory factor (IRF)1 in promoting NLRP3 inflammasome activation and cell death during IAV infection...
February 15, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29285164/resveratrol-alleviates-staphylococcus-aureus-pneumonia-by-inhibition-of-the-nlrp3-inflammasome
#11
Suxia Wu, Jianan Huang
Staphylococcus aureus ( S. aureus ) causes a wide variety of infections, including S. aureus pneumonia. Resveratrol, a natural polyphenolic compound contained in several plant species, exerts various activities, including anti-bacterial and pulmonary protective activities. The aim of the present study was to evaluate the protective effect of resveratrol on a murine model of S. aureus pneumonia and to elucidate the underlying mechanisms. It was found that resveratrol significantly reduced S. aureus -induced mortality, ameliorated lung injury and decreased cytokine levels in the bronchoalveolar lavage fluid and lung tissue of S...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29258190/ifn-%C3%AE-a-contentious-player-in-host-pathogen-interaction-in-tuberculosis
#12
REVIEW
Naveed Sabir, Tariq Hussain, Syed Zahid Ali Shah, Deming Zhao, Xiangmei Zhou
Tuberculosis (TB) is a major health threat to the human population worldwide. The etiology of the disease is Mycobacterium tuberculosis (Mtb), a highly successful intracellular pathogen. It has the ability to manipulate the host immune response and to make the intracellular environment suitable for its survival. Many studies have addressed the interactions between the bacteria and the host immune cells as involving many immune mediators and other cellular players. Interferon-β (IFN-β) signaling is crucial for inducing the host innate immune response and it is an important determinant in the fate of mycobacterial infection...
December 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29222907/the-ameliorative-effect-of-fluoxetine-on-neuroinflammation-induced-by-sleep-deprivation
#13
Maosheng Xia, Xiaowei Li, Li Yang, Jiaan Ren, Guangfeng Sun, Shuang Qi, Alexei Verkhratsky, Baoman Li
It is well known that sleep disorders are harmful to people's health and performance, and growing evidence suggests that sleep deprivation (SD) can trigger neuroinflammation in the brain. The nucleotide-binding domain and leucine-rich repeat protein-3 (NLRP3) inflammasome is reported to be relevant to the neuroinflammation induced by SD, but the regulatory signaling that governs the NLRP3 inflammasome in SD is still unknown. Meanwhile, whether the regulatory action of antidepressants in astrocytes could affect the neuroinflammation induced by SD also remains obscure...
December 9, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29192367/intermedin-1-53-protects-cardiac-fibroblasts-by-inhibiting-nlrp3-inflammasome-activation-during-sepsis
#14
Di Wu, Lin Shi, Pengyang Li, Xianqiang Ni, Jinsheng Zhang, Qing Zhu, Yongfen Qi, Bin Wang
Sepsis is a disease that occurs as a result of systemic inflammatory response syndrome (SIRS) in response to an infection, contributing to multiple organ dysfunction and a high mortality rate. Interleukin-lβ (IL-1β) is a cytokine that plays critical roles in inflammation and cardiac dysfunction during severe sepsis. Intermedin1-53 (IMD1-53 ) has been recently discovered to possess potential endogenous anti-inflammatory and strong cardiovascular protective effects. To investigate whether IMD1-53 can inhibit the NLRP3/caspase-1/IL-1β pathway to alleviate cardiac injury and rescue heart function, sepsis was induced in vivo by caecal ligation and puncture (CLP) surgery, and lipopolysaccharides were used as septic stressors for cardiac fibroblasts (CFs) in vitro...
December 1, 2017: Inflammation
https://www.readbyqxmd.com/read/29105345/estradiol-inhibits-nlrp3-inflammasome-in-fibroblast-like-synoviocytes-activated-by-lipopolysaccharide-and-adenosine-triphosphate
#15
Jianfeng Shi, Weibo Zhao, Haijian Ying, Ying Zhang, Juping Du, Shuaishuai Chen, Jun Li, Bo Shen
OBJECTIVE: Nucleotide binding domain and leucine-rich repeat pyrin 3 domain (NLRP3) inflammasome is known for activating pro-inflammatory cytokines in knee osteoarthritis (OA). This study was performed to identify whether NLRP3 inflammasome can be triggered by lipopolysaccharides (LPS) and adenosine triphos adenine (ATP), which are positively related with knee OA severity in joint-spaces, in human fibroblast-like synoviocytes (FLS), and to identify whether estrogen would inhibit the activation of NLRP3 inflammasome...
November 3, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29063476/fungal-%C3%AE-glucan-activates-the-nlrp3-inflammasome-in-human-bronchial-epithelial-cells-through-ros-production
#16
Yanhua Huang, Meng Hua, Xuefan Cui
The nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3) inflammasome has developed as an important bridge between innate immune and infection recently, and has the ability to drive proteolytic procaspase-1 into bioactive caspase-1, then responsible for proteolytic processing of inflammatory cytokines IL-1β and IL-18. Fungal β-glucan, a major component of fungal cell wall, triggers inflammatory response in multiple immune cells, but rarely described in epithelial cells. Also, the relationship between fungal β-glucan and NLRP3 inflammasome is not clear yet...
February 2018: Inflammation
https://www.readbyqxmd.com/read/28972154/neutrophil-microparticle-production-and-inflammasome-activation-by-hyperglycemia-due-to-cytoskeletal-instability
#17
Stephen R Thom, Veena M Bhopale, Kevin Yu, Weiliang Huang, Maureen A Kane, David J Margolis
Microparticles are lipid bilayer-enclosed vesicles produced by cells under oxidative stress. MP production is elevated in patients with diabetes, but the underlying cellular mechanisms are poorly understood. We hypothesized that raising glucose above the physiological level of 5.5 mm would stimulate leukocytes to produce MPs and activate the nucleotide-binding domain, leucine-rich repeat pyrin domain-containing 3 (NLRP3) inflammasome. We found that when incubated in buffer with up to 20 mm glucose, human and murine neutrophils, but not monocytes, generate progressively more MPs with high interleukin (IL)-1β content...
November 3, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28942141/carbon-monoxide-regulates-glycolysis-dependent-nlrp3-inflammasome-activation-in-macrophages
#18
Do Won Lee, Ha Young Shin, Ji Hun Jeong, Jaeseok Han, Seongho Ryu, Kiichi Nakahira, Jong-Seok Moon
Low dose of carbon monoxide (CO) has anti-inflammatory role through various signaling pathways. Cellular metabolism has been implicated in the activation of inflammation in immune cells. However, the mechanisms by which CO-dependent metabolic regulation affect the immune response remain unclear. Here we show that CO-dependent metabolic pathway regulates the activation of the nucleotide-binding domain, leucine-rich-repeat-containing receptor (NLR), pyrin-domain-containing 3 (NLRP3) inflammasome. CO-releasing molecule-3 (CORM-3) resulted in reduced glycolysis-dependent NLRP3 inflammasome activation in macrophages...
November 18, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28796264/lytic-cell-death-induced-by-melittin-bypasses-pyroptosis-but-induces-nlrp3-inflammasome-activation-and-il-1%C3%AE-release
#19
Fátima Martín-Sánchez, Juan José Martínez-García, María Muñoz-García, Miriam Martínez-Villanueva, José A Noguera-Velasco, David Andreu, Luís Rivas, Pablo Pelegrín
The nucleotide-binding domain and leucine-rich repeat-containing receptor with a pyrin domain 3 (NLRP3) inflammasome is a sensor for different types of infections and alterations of homeostatic parameters, including abnormally high levels of the extracellular nucleotide ATP or crystallization of different metabolites. All NLRP3 activators trigger a similar intracellular pathway, where a decrease in intracellular K(+) concentration and permeabilization of plasma membrane are key steps. Cationic amphipathic antimicrobial peptides and peptide toxins permeabilize the plasma membrane...
August 10, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28790324/the-h7n9-influenza-a-virus-infection-results-in-lethal-inflammation-in-the-mammalian-host-via-the-nlrp3-caspase-1-inflammasome
#20
Rongrong Ren, Shuxian Wu, Jialin Cai, Yuqin Yang, Xiaonan Ren, Yanling Feng, Lixiang Chen, Boyin Qin, Chunhua Xu, Hua Yang, Zhigang Song, Di Tian, Yunwen Hu, Xiaohui Zhou, Guangxun Meng
The avian origin influenza A virus (IAV) H7N9 has caused a considerable number of human infections associated with high rates of death since its emergence in 2013. As a vital component of the host innate immune system, the nucleotide-binding domain leucine-rich repeat containing receptor, pyrin domain containing 3 (NLRP3) inflammasome plays a critical role against H1N1 viral infection. However, the function of NLRP3 inflammasome in host immunological responses to the lethal H7N9 virus is still obscure. Here, we demonstrated that mice deficient for NLRP3 inflammasome components, including NLRP3, caspase-1, and Apoptosis-associated speck-like protein containing a CARD (ASC), were less susceptible to H7N9 viral challenge than wild type (WT) controls...
August 8, 2017: Scientific Reports
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