Izabela Florek, Tomasz Sacha, Magdalena Zawada, Sylwia Czekalska, Kajetana Foryciarz, Dorota Cwynar, Elzbieta Pecek, Aleksander B Skotnicki
Chronic Myeloid Leukemia (CML), belonging to mieloproliferative syndromes, is one of the myeloproliferative clonal hyperplasia. It is caused by the Philadelphia chromosome resulting from the reciprocal translocation, t(9;22) between the long arms of chromosomes 9 and 22. This results in the production of fusion BCR-ABL transcript and chimeric protein--tyrosine kinase activity. This protein leads to increased proliferation, resistance to apoptosis, and worse adhesion of CML cells. Molecular analysis are very important in the era treatment of CML by tyrosine kinase inhibitors (TKI)...
2010: Przegla̧d Lekarski