keyword
https://read.qxmd.com/read/21591355/-implementation-of-direct-sequencing-as-a-method-of-abl-gene-mutations-analysis-in-patients-with-chronic-myeloid-leukemia-treated-with-tyrosine-kinase-inhibitor
#21
JOURNAL ARTICLE
Izabela Florek, Tomasz Sacha, Magdalena Zawada, Sylwia Czekalska, Kajetana Foryciarz, Dorota Cwynar, Elzbieta Pecek, Aleksander B Skotnicki
Chronic Myeloid Leukemia (CML), belonging to mieloproliferative syndromes, is one of the myeloproliferative clonal hyperplasia. It is caused by the Philadelphia chromosome resulting from the reciprocal translocation, t(9;22) between the long arms of chromosomes 9 and 22. This results in the production of fusion BCR-ABL transcript and chimeric protein--tyrosine kinase activity. This protein leads to increased proliferation, resistance to apoptosis, and worse adhesion of CML cells. Molecular analysis are very important in the era treatment of CML by tyrosine kinase inhibitors (TKI)...
2010: Przegla̧d Lekarski
https://read.qxmd.com/read/21527532/overexpression-of-microrna-16-2-contributes-to-the-abnormal-erythropoiesis-in-polycythemia-vera
#22
JOURNAL ARTICLE
Paola Guglielmelli, Lorenzo Tozzi, Costanza Bogani, Ilaria Iacobucci, Vanessa Ponziani, Giovanni Martinelli, Alberto Bosi, Alessandro M Vannucchi et al.
Deregulated expression of microRNAs is associated with neoplasia. Here, we show that mature miR-16 levels are abnormally increased in CD34(+) cells of patients with polycythemia vera as a consequence of preferential expression of miR-16-2 on chromosome 3 rather than of miR-16-1 on chromosome 13. Forced expression of miRNA-16 in normal CD34(+) cells stimulated erythroid cell proliferation and maturation. Conversely, exposure of polycythemia vera CD34(+) cells to small interfering RNA against pre-miR-16-2 reduced erythroid colonies and largely prevented formation of erythropoietin-independent colonies; myeloid progenitors remained unaffected...
June 23, 2011: Blood
https://read.qxmd.com/read/10800165/diagnosis-of-essential-thrombocythemia-at-platelet-counts-between-400-and-600x10-9-l-gruppo-italiano-malattie-mieloproliferative-croniche-gimmc
#23
JOURNAL ARTICLE
S Sacchi, G Vinci, L Gugliotta, S Rupoli, L Gargantini, V Martinelli, S Baravelli, M Lazzarino, G Finazzi
BACKGROUND AND OBJECTIVE: Diagnostic criteria for essential thrombocythemia (ET) remain essentially negative, that is, exclusion of other myeloproliferative diseases and causes of reactive thrombocytosis. A platelet count above 600x10(9)/L is still generally considered an absolute diagnostic criterion although new protocols for positive diagnostic criteria have recently been proposed, reducing the stringency of a definite platelet limit. This study demonstrates that a platelet count 600x10(9)/L is not a reliable diagnostic criterion for ET, especially in the early stages...
May 2000: Haematologica
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