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Yong-Moon Mark Park, Teresa T Fung, Susan E Steck, Jiajia Zhang, Linda J Hazlett, Kyungdo Han, Seung-Hwan Lee, Anwar T Merchant
OBJECTIVE: To examine the associations among the Dietary Approaches to Stop Hypertension (DASH)-style diet, the Healthy Eating Index (HEI), and mortality risk in metabolically obese normal-weight (MONW) adults. PATIENTS AND METHODS: Data were from normal-weight (body mass index of 18.5 to <25) adults aged 30 to 90 years at baseline in the Third National Health and Nutrition Examination Survey, October 18, 1988, through October 15, 1994, followed up for deaths (all-cause, cardiovascular, and cancer related) until December 31, 2011...
October 2016: Mayo Clinic Proceedings
Yong-Moon Mark Park, Susan E Steck, Teresa T Fung, Jiajia Zhang, Linda J Hazlett, Kyungdo Han, Seung-Hwan Lee, Hyuk-Sang Kwon, Anwar T Merchant
BACKGROUND & AIMS: There is sparse evidence on the relationship between the Mediterranean diet, Dietary Approaches to Stop Hypertension (DASH) style diet, and metabolic health, especially comparing cardiometabolic phenotypes among in normal weight and obese populations. We aimed to investigate the association of the Mediterranean diet scores (MDS) and DASH index with metabolically healthy obese (MHO) and metabolically obese normal weight (MONW) phenotypes in a representative U.S. POPULATION: HASH(0x4c00198) METHODS: MDS and DASH index were calculated using dietary data from 2767 adults aged 20-90 years without any prior diagnosis of cancer or cardiovascular disease from the National Health and Nutrition Examination Survey III, 1988-1994...
September 8, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Cherlyn Ding, Zhiling Chan, Faidon Magkos
PURPOSE OF REVIEW: Obesity is commonly associated with metabolic dysfunction but there are obese persons who are metabolically healthy. On the opposite side of the coin, there are lean persons who carry multiple cardiometabolic risk factors, typically referred to as metabolically obese, normal-weight (MONW). This has called into question our understanding of obesity and metabolic dysfunction, as an appearance of normal weight may mask significant comorbidities and delay health interventions...
November 2016: Current Opinion in Clinical Nutrition and Metabolic Care
O Rotar, A Konradi, S Shalnova, Y Balanova, A Deev, E Oschepkova, Y Karpov, I Chazova, S Boytsov, E Shlyakhto
OBJECTIVE: Metabolic health can be the determinant factor of the cardiovascular diseases independently of presence of obesity. The study estimates prevalence of metabolically healthy obesity (MHO) and metabolically obese normal weight (MONW) phenotypes in regions of Russian Federation. DESIGN AND METHOD: A novel epidemiology survey of cardiovascular risk in regions of RF with different climatic, geographic, economic and demographic characteristics (ESSE-RF) was performed in a multi-step stratified random sample of approximately 1600 participants aged 25-65 years in every 13 selected region (Volgograd, Vologda, Voronezh, Vladivostok, Ivanovo, Kemerovo, Krasnoyarsk, Samara, Orenburg, Tomsk, Tyumen, Saint-Petersburg and Northern Osetia-Alania)...
September 2016: Journal of Hypertension
Young-Gyun Seo, Ho-Chun Choi, Belong Cho
OBJECTIVE: Both metabolic syndrome (MetS) and obesity increase the risk of stroke. However, few studies have compared the risks of stroke associated with metabolically obese non-obese weight (MONW) and metabolically healthy obesity (MHO). This study aimed to compare the prevalence of stroke in MONW and MHO individuals. METHODS: A total of 25,744 subjects aged ≥40 years were selected from the 2007-2014 Korean National Health and Nutrition Examination Survey. MetS was defined using 2001 National Cholesterol Education Program/Adult Treatment Panel III and 2005 American Heart Association/National Heart, Lung, and Blood Institute criteria...
2016: PloS One
R Díaz-Rúa, E M van Schothorst, J Keijer, A Palou, P Oliver
BACKGROUND/OBJECTIVES: Consumption of fat-rich foods is associated with obesity and related alterations. However, there is a group of individuals, the metabolically obese normal-weight (MONW) subjects, who present normal body weight but have metabolic features characteristic of the obese status, including fat deposition in critical tissues such as liver, recognized as a major cause for the promotion of metabolic diseases. Our aim was to better understand metabolic alterations present in liver of MONW rats applying whole genome transcriptome analysis...
August 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Ottavio Bosello, Maria Pia Donataccio, Massimo Cuzzolaro
Obesity is still defined on the basis of body mass index (BMI) and BMI in itself is generally accepted as a strong predictor of overall early mortality. However, an inverse association between BMI and mortality has been reported in patients with many disease states and in several clinical settings: hemodialysis, cardiovascular diseases, hypertension, stroke, diabetes, chronic obstructive pulmonary disease, surgery, etc. This unexpected phenomenon is usually called obesity-survival paradox (OP). The contiguous concepts of metabolically healthy obesity (MHO, a phenotype having BMI ≥ 30 but not having any metabolic syndrome component and having a homeostasis model assessment of insulin resistance, HOMA, <2...
June 2016: Eating and Weight Disorders: EWD
Michel P Hermans, K Daniel Amoussou-Guenou, Evariste Bouenizabila, Shaukat S Sadikot, Sylvie A Ahn, Michel F Rousseau
BACKGROUND: Type 2 diabetes (T2DM) is associated with obesity, insulin resistance and the metabolic syndrome (MetS). In non-diabetic populations, features of metabolic obesity (MO) are observed in a minority of normal-weight (NW) subjects. The cardiometabolic status of metabolically obese but normal-weight (MONW) individuals has not yet been phenotyped in T2DM. PATIENTS AND METHODS: Prevalence and features of MONW were analyzed in 1244 T2DM patients, in whom MONW was identified as a BMI <25...
April 2016: Diabetes & Metabolic Syndrome
Katarzyna Kolačkov, Łukasz Łaczmański, Felicja Lwow, David Ramsey, Aleksandra Zdrojowy-Wełna, Małgorzata Tupikowska, Grażyna Bednarek-Tupikowska
BACKGROUND: The minor allele frequencies (MAFs) of the FTO gene vary substantially among different ethnic groups, and this variation may explain, to some degree, the differences between estimates of the effects of these alleles on body fat distribution indicators. OBJECTIVES: The aim of this study was to investigate the prevalence of fat mass and obesity associated (FTO) gene variants characterizing the structure of FTO haplotypes in a large Polish population, and to examine the influence of FTO gene variants on body fat distribution among metabolically obese normal weight (MONW) individuals, i...
January 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Dhia J Al-Timimi, Hivi M Mahmoud, Dilveen A Mohammed, Idris H Ahmed
INTRODUCTION: There is increasing evidence on the association between lower serum zinc levels and metabolically unhealthy status in normal weight individuals'. AIM: Our aim was to investigate serum zinc levels in a sample of siblings of patients with type 2 diabetes mellitus and to ascertain its relation with metabolic syndrome components. MATERIALS AND METHODS: Serum zinc was determined in 331 apparently healthy individuals, 201 were siblings of patients with type 2 diabetes mellitus (type 2 DM) and 130 individuals with negative family history of diabetes (healthy controls), with age range 20-40 years...
December 2015: Journal of Clinical and Diagnostic Research: JCDR
Sima Hashemipour, Neda Esmailzadehha, Mahdieh Mohammadzadeh, Amir Ziaee
BACKGROUND: Insulin resistance (IR) is not limited to obese individuals. Normal weight individuals may also be insulin resistant. The aim of this study was to determine the association of lifestyle and diet patterns with IR in normal weight Iranian men. METHODS: This cross-sectional study was conducted in 232 men with a body mass index lower than 25 kg/m(2) (aged 20-72 years old) between September 2010 and April 2011 in Qazvin, Iran. Metabolically obese normal weight (MONW) was defined as IR using the homeostatic model assessment (HOMA)...
September 2016: Eating and Weight Disorders: EWD
Jae-Woo Kim, Do Hoon Kim, Yong Kyun Roh, Sang Yhun Ju, Hyo-Yun Nam, Ga-Eun Nam, Dong-Won Kim, Seung-Hyun Lee, Chung-Woo Lee, Kyungdo Han, Yong-Gyu Park
The purpose of this study was to examine the relationship between serum ferritin levels and metabolically obese normal weight (MONW) and to determine the appropriate cut-off value of serum ferritin for the prediction of clinical metabolic status in nonobese Korean adults. Data from 9411 participants in the fourth (2008) and fifth (2010) annual Korea National Health and Nutrition Examination Surveys were used in this study. MONW was determined by combining National Cholesterol Education Program Adult Treatment Panel III criteria, Wildman criteria, and homeostatic model assessment criteria for metabolic healthy obesity...
December 2015: Medicine (Baltimore)
Azadeh Mottaghi, Parvin Mirmiran, Hossein Delshad, Fereidoun Azizi
BACKGROUND: The aim of this community-based study is to ascertain the effect of different obesity phenotypes on the incidence of chronic kidney disease in Iranian adults. STUDY DESIGN: A prospective cohort study, the Tehran Lipid Glucose Study (TLGS). SETTING AND PARTICIPANTS: Adults aged ≥ 20 years with a mean age of 40.38 years (54.8% female) who were free from chronic kidney disease (CKD) at baseline (phase 1) and were followed up at 3 time stages (phases 2, 3, and 4) for a mean duration of 9...
December 9, 2015: Journal of the American College of Nutrition
B Wang, R Zhuang, X Luo, L Yin, C Pang, T Feng, H You, Y Zhai, Y Ren, L Zhang, L Li, J Zhao, D Hu
The objective of the present study was to summarize the prevalence and influencing factors of metabolically healthy obese (MHO) and metabolically obese but normal weight (MONW) among people ≥ 18 years old in the general population worldwide. We searched for studies of the prevalence of MHO and MONW published in English and Chinese up to October 2013. Pooled prevalence estimates were calculated by a random-effects model according to a Q test. The effects of gender, region, age, sample size, smoking, and alcohol consumption on MHO and MONW were analyzed...
October 2015: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
Kausik Das, Abhijit Chowdhury
INTRODUCTION: Non-alcoholic fatty liver (NAFL) in the absence of overweight and/or obesity, defined by the anthropometric parameter, body mass index (BMI), has been designated as 'lean NASH.' While maintaining a close pathophysiological link with metabolic syndrome (MS) and insulin resistance (IR), the presence of subtle alterations in measures of total body and regional adiposity not exceeding the designed cut-offs, are hallmarks of 'lean NASH.' MATERIAL AND METHODS: Available literature related to non-alcoholic steatohepatitis (NASH) in lean or non-obese individuals and its pathogenesis in general published in English language journals till the time of manuscript preparation were reviewed and critically analysed...
December 2013: Hepatology International
A Amouzegar, E Kazemian, S Gharibzadeh, L Mehran, M Tohidi, F Azizi
AIM: The association between insulin resistance and thyroid function in euthyroid subjects has not yet been clarified. This study aimed to investigate the association between thyroid function within the normal reference range and insulin resistance in participants of the Tehran Thyroid Study (TTS). METHODS: This cross-sectional study was conducted within the framework of the TTS. Of 5786 subjects aged ≥ 20 years, 2758 euthyroid subjects free of thyroid disorders, diabetes, chronic kidney disease and cardiovascular disease, and not taking steroids and lipid-lowering agents, were included...
December 2015: Diabetes & Metabolism
S Hashemipour, N Esmailzadehha, H Hamid, S Oveisi, P Yakhchaliha, A Ziaee
PURPOSE: Metabolically obese but normal weight (MONW) is associated with higher risk of type 2 diabetes, dyslipidemia, and hypertension. The aim of this study was to evaluate the association of metabolic syndrome components with MONW in each sex in Iranian population. METHODS: This cross-sectional study was performed on 417 normal weight subjects in Qazvin, Iran between September 2010 and April 2011. MONW was defined by insulin resistance (IR) using the homeostatic model assessment (HOMA)...
October 2015: Journal of Endocrinological Investigation
S-H Lee, K Han, H K Yang, H-S Kim, J-H Cho, H-S Kwon, Y-M Park, B-Y Cha, K-H Yoon
OBJECTIVES: Metabolically obese but normal weight (MONW) individuals constitute a subgroup of normal weight individuals that display impaired insulin sensitivity with a higher risk of developing diabetes, cardiovascular disease and mortality. We aimed to propose a novel criterion for defining MONW by examining the usefulness and the cutoff value of the TyG index, a product of the levels of triglycerides and glucose, in identifying MONW individuals. In addition, the performance of this criterion in predicting the future incidence of diabetes was assessed...
2015: Nutrition & Diabetes
Marina Shargorodsky
OBJECTIVE: Obesity appears to be one of the major risk factors for metabolic complications. However, no direct relationship between body weight and metabolic abnormalities exists. The present study was designed to investigate the impact of body mass index (BMI) and the presence of metabolic syndrome (MS) on early vascular atherosclerotic changes, as determined by augmentation index (AI) and pulse wave velocity (PWV). DESIGN AND METHODS: The 285 study participants were divided into four groups according to BMI and the presence of MS...
2015: Journal of the American College of Nutrition
H K Yang, S H Lee, K Han, B Kang, S Y Lee, K H Yoon, H S Kwon, Y M Park
AIM: This study investigated whether serum zinc concentration is associated with glucose tolerance, insulin resistance and metabolic health status in Korean adults. METHODS: Subjects with available serum zinc levels were recruited from the fifth Korea National Health and Nutrition Examination Survey (KNHANESV) cohort. Those in the highest quartile on homoeostasis model assessment for insulin resistance (HOMA-IR) and with a body mass index (BMI) of 18.5-25kg/m(2) were classified as metabolically obese and normal weight (MONW)...
September 2015: Diabetes & Metabolism
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