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https://www.readbyqxmd.com/read/29676049/moderate-weight-loss-improves-body-composition-and-metabolic-function-in-metabolically-unhealthy-lean-subjects
#1
Yu Chung Chooi, Cherlyn Ding, Zhiling Chan, John Choo, Suresh Anand Sadananthan, Navin Michael, Yijun Lee, S Sendhil Velan, Faidon Magkos
OBJECTIVE: Individuals who have "metabolically obese normal weight" (MONW) have an increased risk for cardiometabolic disease. Moderate weight loss has multiple benefits in people with obesity, but its effects in lean people are unknown. Thus, the effects of diet-induced 5% weight loss on body composition and metabolic function in MONW subjects were evaluated. METHODS: Total body fat, visceral adipose tissue (VAT) and subcutaneous abdominal adipose tissue (SAT) volumes, intrahepatic and intramyocellular lipid contents, insulin sensitivity (hyperinsulinemic-euglycemic clamp), glucose tolerance, and postprandial insulin secretion and clearance rates (mixed meal with minimal modeling) were measured before and after 4...
April 19, 2018: Obesity
https://www.readbyqxmd.com/read/29566703/cognitive-impairment-in-metabolically-obese-normal-weight-rats-identification-of-early-biomarkers-in-peripheral-blood-mononuclear-cells
#2
Margalida Cifre, Andreu Palou, Paula Oliver
BACKGROUND: Metabolically-obese, normal-weight (MONW) individuals are not obese in terms of weight and height but have a number of obesity-related features (e.g. greater visceral adiposity, insulin resistance, and increased risk of cardiovascular disease). The MONW phenotype is related to the intake of unbalanced diets, such as those rich in fat. Increasing evidence shows a relationship between high-fat diet consumption and mild cognitive impairment and dementia. Thus, MONW individuals could be at a greater risk of cognitive dysfunction...
March 22, 2018: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/29445240/high-fat-diet-induced-metabolically-obese-and-normal-weight-rabbit-model-shows-early-vascular-dysfunction-mechanisms-involved
#3
Gabriela Alarcon, Julieta Roco, Mirta Medina, Analia Medina, Maria Peral, Susana Jerez
BACKGROUND: Obesity contributes significantly to the development and evolution of cardiovascular disease (CVD) which is believed to be mediated by oxidative stress, inflammation and endothelial dysfunction. However, the vascular health of metabolically obese and normal weight (MONW) individuals is not completely comprehended. OBJECTIVES: The purpose of our study was to evaluate vascular function on the basis of a high fat diet (HFD)-MONW rabbit model. SUBJECTS: Twenty four male rabbits were randomly assigned to receive either a regular diet (CD, n = 12) or a high-fat diet (18% extra fat on the regular diet, HFD, n = 12) for 6 weeks...
January 30, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29351481/regulation-of-glucose-metabolism-in-non-diabetic-metabolically-obese-normal-weight-asians
#4
Cherlyn Ding, Zhiling Chan, Yu Chung Chooi, John Choo, Suresh Anand Sadananthan, Amanda Chang, S Sasikala, Navin Michael, S Sendhil Velan, Faidon Magkos
Type 2 diabetes in Asia occurs largely in the absence of obesity. The metabolically-obese normal-weight (MONW) phenotype refers to lean subjects with metabolic dysfunction that is typically observed in people with obesity, and is associated with increased risk for diabetes. Previous studies evaluated MONW subjects who had greater BMI or total body fat than respective control groups, making interpretation of the results difficult. We evaluated insulin sensitivity (hyperinsulinemic-euglycemic clamp), insulin secretion (mixed meal with oral minimal modeling), intra-abdominal, muscle, and liver fat contents (magnetic resonance), and fasting and postprandial glucose and insulin concentrations in 18 MONW subjects and 18 metabolically-healthy controls matched for age (43{plus minus}3 and 40{plus minus}3 y; P=0...
January 2, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29341865/evidence-of-genetic-predisposition-for-metabolically-healthy-obesity-and-metabolically-obese-normal-weight
#5
Lam Opal Huang, Ruth Loos, Tuomas Oskari Kilpeläinen
Obesity has evolved into a global pandemic, which constitutes a major threat to public health. The majority of obesity-related health care costs are due to cardiometabolic complications, such as insulin resistance, dyslipidemia, and hypertension, which are risk factors for type 2 diabetes and cardiovascular disease. However, many obese individuals, often called metabolically healthy obese (MHO), seem to be protected from these cardiometabolic complications. Conversely, there is a group of individuals who suffer from cardiometabolic complications despite being of normal weight; a condition termed metabolically obese normal weight (MONW)...
December 20, 2017: Physiological Genomics
https://www.readbyqxmd.com/read/29073292/tofi-phenotype-its-effect-on-the-occurrence-of-diabetes
#6
REVIEW
Zygmunt Zdrojewicz, Ewa Popowicz, Marta Szyca, Tomasz Michalik, Bartłomiej Śmieszniak
Recent studies have reported a significant increase in the incidence of type 2 diabetes in the past 30 years. They also predict that this trend will continue. This is related to a change in lifestyle, which results in a parallel increase in the incidence of overweight and obesity. However, symptoms of the metabolic syndrome, so far closely related to abdominal obesity, are relatively common among people with normal body mass index (BMI) and waist circumference. The aim of the study is to present the TOFI phenotype (thin outside, fat inside) as an important factor in pathogenesis of type 2 diabetes...
2017: Pediatric Endocrinology, Diabetes, and Metabolism
https://www.readbyqxmd.com/read/28384340/parathyroid-hormone-and-vitamin-d-are-associated-with-the-risk-of-metabolic-obesity-in-a-middle-aged-and-older-korean-population-with-preserved-renal-function-a-cross-sectional-study
#7
Jeonghoon Ha, Kwanhoon Jo, Dong-Jun Lim, Jung-Min Lee, Sang-Ah Chang, Moo I L Kang, Bong Yun Cha, Min-Hee Kim
BACKGROUND: In general, obesity is a major contributor to metabolic syndrome (MetS) and is associated with insulin resistance (IR). Metabolically obese but normal weight (MONW) individuals present metabolic abnormalities and features of MetS despite having a normal range of body mass index (BMI). In recent years, different subtypes of obesity have been introduced, including metabolically healthy obese (MHO) and metabolically obese obese (MOO). Also, it has been reported that vitamin D and parathyroid hormone (PTH) are possibly linked with MetS...
2017: PloS One
https://www.readbyqxmd.com/read/27885970/-cpt1a-gene-expression-in-peripheral-blood-mononuclear-cells-as-an-early-biomarker-of-diet-related-metabolic-alterations
#8
Rubén Díaz-Rúa, Andreu Palou, Paula Oliver
BACKGROUND: Research on biomarkers that provide early information about the development of future metabolic alterations is an emerging discipline. Gene expression analysis in peripheral blood mononuclear cells (PBMC) is a promising tool to identify subjects at risk of developing diet-related diseases. OBJECTIVE: We analysed PBMC expression of key energy homeostasis-related genes in a time-course analysis in order to find out early markers of metabolic alterations due to sustained intake of high-fat (HF) and high-protein (HP) diets...
2016: Food & Nutrition Research
https://www.readbyqxmd.com/read/27776717/metabolically-obese-individuals-of-normal-weight-have-a-high-risk-of-25-hydroxyvitamin-d-deficiency
#9
Xiaoli Wang, Xiangyun Chang, Yurong Zhu, Huan Wang, Kan Sun
BACKGROUND: Vitamin D status is related to obesity-related metabolic disorders. We investigated the risk of 25-hydroxyvitamin D [25(OH)D] deficiency among different metabolic phenotypes. METHODS: This prospective cross-sectional study evaluated 1,292 individuals who were ≥40 years old. Participants were classified as metabolically healthy and normal weight (MHNW), metabolically obese but normal weight (MONW), metabolically healthy but obese (MHO) or metabolically unhealthy and obese (MUO)...
October 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27712636/diet-quality-and-mortality-risk-in-metabolically-obese-normal-weight-adults
#10
Yong-Moon Mark Park, Teresa T Fung, Susan E Steck, Jiajia Zhang, Linda J Hazlett, Kyungdo Han, Seung-Hwan Lee, Anwar T Merchant
OBJECTIVE: To examine the associations among the Dietary Approaches to Stop Hypertension (DASH)-style diet, the Healthy Eating Index (HEI), and mortality risk in metabolically obese normal-weight (MONW) adults. PATIENTS AND METHODS: Data were from normal-weight (body mass index of 18.5 to <25) adults aged 30 to 90 years at baseline in the Third National Health and Nutrition Examination Survey, October 18, 1988, through October 15, 1994, followed up for deaths (all-cause, cardiovascular, and cancer related) until December 31, 2011...
October 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27665232/mediterranean-diet-dietary-approaches-to-stop-hypertension-dash-style-diet-and-metabolic-health-in-u-s-adults
#11
Yong-Moon Mark Park, Susan E Steck, Teresa T Fung, Jiajia Zhang, Linda J Hazlett, Kyungdo Han, Seung-Hwan Lee, Hyuk-Sang Kwon, Anwar T Merchant
BACKGROUND & AIMS: There is sparse evidence on the relationship between the Mediterranean diet, Dietary Approaches to Stop Hypertension (DASH) style diet, and metabolic health, especially comparing cardiometabolic phenotypes among in normal weight and obese populations. We aimed to investigate the association of the Mediterranean diet scores (MDS) and DASH index with metabolically healthy obese (MHO) and metabolically obese normal weight (MONW) phenotypes in a representative U.S. POPULATION: <AbstractText Label="METHODS">MDS and DASH index were calculated using dietary data from 2767 adults aged 20-90 years without any prior diagnosis of cancer or cardiovascular disease from the National Health and Nutrition Examination Survey III, 1988-1994...
October 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27552473/lean-but-not-healthy-the-metabolically-obese-normal-weight-phenotype
#12
REVIEW
Cherlyn Ding, Zhiling Chan, Faidon Magkos
PURPOSE OF REVIEW: Obesity is commonly associated with metabolic dysfunction but there are obese persons who are metabolically healthy. On the opposite side of the coin, there are lean persons who carry multiple cardiometabolic risk factors, typically referred to as metabolically obese, normal-weight (MONW). This has called into question our understanding of obesity and metabolic dysfunction, as an appearance of normal weight may mask significant comorbidities and delay health interventions...
November 2016: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/27508611/-op-2a-03-metabolically-healthy-obesity-and-metabolically-obese-normal-weight-in-russian-population
#13
O Rotar, A Konradi, S Shalnova, Y Balanova, A Deev, E Oschepkova, Y Karpov, I Chazova, S Boytsov, E Shlyakhto
OBJECTIVE: Metabolic health can be the determinant factor of the cardiovascular diseases independently of presence of obesity. The study estimates prevalence of metabolically healthy obesity (MHO) and metabolically obese normal weight (MONW) phenotypes in regions of Russian Federation. DESIGN AND METHOD: A novel epidemiology survey of cardiovascular risk in regions of RF with different climatic, geographic, economic and demographic characteristics (ESSE-RF) was performed in a multi-step stratified random sample of approximately 1600 participants aged 25-65 years in every 13 selected region (Volgograd, Vologda, Voronezh, Vladivostok, Ivanovo, Kemerovo, Krasnoyarsk, Samara, Orenburg, Tomsk, Tyumen, Saint-Petersburg and Northern Osetia-Alania)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27494241/the-relationship-between-metabolically-obese-non-obese-weight-and-stroke-the-korea-national-health-and-nutrition-examination-survey
#14
COMPARATIVE STUDY
Young-Gyun Seo, Ho-Chun Choi, Belong Cho
OBJECTIVE: Both metabolic syndrome (MetS) and obesity increase the risk of stroke. However, few studies have compared the risks of stroke associated with metabolically obese non-obese weight (MONW) and metabolically healthy obesity (MHO). This study aimed to compare the prevalence of stroke in MONW and MHO individuals. METHODS: A total of 25,744 subjects aged ≥40 years were selected from the 2007-2014 Korean National Health and Nutrition Examination Survey. MetS was defined using 2001 National Cholesterol Education Program/Adult Treatment Panel III and 2005 American Heart Association/National Heart, Lung, and Blood Institute criteria...
2016: PloS One
https://www.readbyqxmd.com/read/27089994/isocaloric-high-fat-feeding-directs-hepatic-metabolism-to-handling-of-nutrient-imbalance-promoting-liver-fat-deposition
#15
R Díaz-Rúa, E M van Schothorst, J Keijer, A Palou, P Oliver
BACKGROUND/OBJECTIVES: Consumption of fat-rich foods is associated with obesity and related alterations. However, there is a group of individuals, the metabolically obese normal-weight (MONW) subjects, who present normal body weight but have metabolic features characteristic of the obese status, including fat deposition in critical tissues such as liver, recognized as a major cause for the promotion of metabolic diseases. Our aim was to better understand metabolic alterations present in liver of MONW rats applying whole genome transcriptome analysis...
August 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27043948/obesity-or-obesities-controversies-on-the-association-between-body-mass-index-and-premature-mortality
#16
REVIEW
Ottavio Bosello, Maria Pia Donataccio, Massimo Cuzzolaro
Obesity is still defined on the basis of body mass index (BMI) and BMI in itself is generally accepted as a strong predictor of overall early mortality. However, an inverse association between BMI and mortality has been reported in patients with many disease states and in several clinical settings: hemodialysis, cardiovascular diseases, hypertension, stroke, diabetes, chronic obstructive pulmonary disease, surgery, etc. This unexpected phenomenon is usually called obesity-survival paradox (OP). The contiguous concepts of metabolically healthy obesity (MHO, a phenotype having BMI ≥ 30 but not having any metabolic syndrome component and having a homeostasis model assessment of insulin resistance, HOMA, <2...
June 2016: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/26960924/the-normal-weight-type-2-diabetes-phenotype-revisited
#17
Michel P Hermans, K Daniel Amoussou-Guenou, Evariste Bouenizabila, Shaukat S Sadikot, Sylvie A Ahn, Michel F Rousseau
BACKGROUND: Type 2 diabetes (T2DM) is associated with obesity, insulin resistance and the metabolic syndrome (MetS). In non-diabetic populations, features of metabolic obesity (MO) are observed in a minority of normal-weight (NW) subjects. The cardiometabolic status of metabolically obese but normal-weight (MONW) individuals has not yet been phenotyped in T2DM. PATIENTS AND METHODS: Prevalence and features of MONW were analyzed in 1244 T2DM patients, in whom MONW was identified as a BMI <25...
April 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/26935496/the-frequencies-of-haplotypes-of-fto-gene-variants-and-their-association-with-the-distribution-of-body-fat-in-non-obese-poles
#18
Katarzyna Kolačkov, Łukasz Łaczmański, Felicja Lwow, David Ramsey, Aleksandra Zdrojowy-Wełna, Małgorzata Tupikowska, Grażyna Bednarek-Tupikowska
BACKGROUND: The minor allele frequencies (MAFs) of the FTO gene vary substantially among different ethnic groups, and this variation may explain, to some degree, the differences between estimates of the effects of these alleles on body fat distribution indicators. OBJECTIVES: The aim of this study was to investigate the prevalence of fat mass and obesity associated (FTO) gene variants characterizing the structure of FTO haplotypes in a large Polish population, and to examine the influence of FTO gene variants on body fat distribution among metabolically obese normal weight (MONW) individuals, i...
January 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/26816880/serum-zinc-and-metabolic-health-status-in-siblings-of-patients-with-type-2-diabetes-mellitus
#19
Dhia J Al-Timimi, Hivi M Mahmoud, Dilveen A Mohammed, Idris H Ahmed
INTRODUCTION: There is increasing evidence on the association between lower serum zinc levels and metabolically unhealthy status in normal weight individuals'. AIM: Our aim was to investigate serum zinc levels in a sample of siblings of patients with type 2 diabetes mellitus and to ascertain its relation with metabolic syndrome components. MATERIALS AND METHODS: Serum zinc was determined in 331 apparently healthy individuals, 201 were siblings of patients with type 2 diabetes mellitus (type 2 DM) and 130 individuals with negative family history of diabetes (healthy controls), with age range 20-40 years...
December 2015: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/26729428/association-of-meat-and-dairy-consumption-with-normal-weight-metabolic-obesity-in-men-the-qazvin-metabolic-diseases-study
#20
Sima Hashemipour, Neda Esmailzadehha, Mahdieh Mohammadzadeh, Amir Ziaee
BACKGROUND: Insulin resistance (IR) is not limited to obese individuals. Normal weight individuals may also be insulin resistant. The aim of this study was to determine the association of lifestyle and diet patterns with IR in normal weight Iranian men. METHODS: This cross-sectional study was conducted in 232 men with a body mass index lower than 25 kg/m(2) (aged 20-72 years old) between September 2010 and April 2011 in Qazvin, Iran. Metabolically obese normal weight (MONW) was defined as IR using the homeostatic model assessment (HOMA)...
September 2016: Eating and Weight Disorders: EWD
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