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https://www.readbyqxmd.com/read/29458745/sleep-duration-independently-influences-metabolic-body-size-phenotype-in-children-and-adolescents-a-population-based-study
#1
Han Hyuk Lim
BACKGROUND: Epidemiologic studies have found an association between sleep duration and obesity. However, the relationship between sleep duration and metabolic body size phenotype in children and adolescents remains unknown. METHODS: In this cross-sectional study, 3650 participants (1946 boys and 1704 girls) from the Korean National Health and Nutrition Examination Survey 2007-2012 were classified into four phenotypes according to body mass index and metabolic heath status based on the definition of metabolic syndrome by NCEP-ATP III or the International Diabetes Federation...
February 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29444707/percutaneous-transhepatic-vs-endoscopic-retrograde-biliary-drainage-for-suspected-malignant-hilar-obstruction-study-protocol-for-a-randomized-controlled-trial
#2
Firas Al-Kawas, Harry Aslanian, John Baillie, Filip Banovac, Jonathan M Buscaglia, James Buxbaum, Amitabh Chak, Bradford Chong, Gregory A Coté, Peter V Draganov, Kulwinder Dua, Valerie Durkalski, B Joseph Elmunzer, Lydia D Foster, Timothy B Gardner, Brian S Geller, Priya Jamidar, Laith H Jamil, Rajesh N Keswani, Mouen A Khashab, Gabriel D Lang, Ryan Law, David Lichtenstein, Simon K Lo, Sean McCarthy, Silvio Melo, Daniel Mullady, Jose Nieto, J Bayne Selby, Vikesh K Singh, Rebecca L Spitzer, Brian Strife, Paul Tarnaksy, Jason R Taylor, Jeffrey Tokar, Andrew Y Wang, April Williams, Field Willingham, Patrick Yachimski
BACKGROUND: The optimal approach to the drainage of malignant obstruction at the liver hilum remains uncertain. We aim to compare percutaneous transhepatic biliary drainage (PTBD) to endoscopic retrograde cholangiography (ERC) as the first intervention in patients with cholestasis due to suspected malignant hilar obstruction (MHO). METHODS: The INTERCPT trial is a multi-center, comparative effectiveness, randomized, superiority trial of PTBD vs. ERC for decompression of suspected MHO...
February 14, 2018: Trials
https://www.readbyqxmd.com/read/29433580/dietary-patterns-and-physical-activity-in-the-metabolically-un-healthy-obese-the-dutch-lifelines-cohort-study
#3
Sandra N Slagter, Eva Corpeleijn, Melanie M van der Klauw, Anna Sijtsma, Linda G Swart-Busscher, Corine W M Perenboom, Jeanne H M de Vries, Edith J M Feskens, Bruce H R Wolffenbuttel, Daan Kromhout, Jana V van Vliet-Ostaptchouk
BACKGROUND: Diversity in the reported prevalence of metabolically healthy obesity (MHO), suggests that modifiable factors may be at play. We evaluated differences in dietary patterns and physical activity between MHO and metabolically unhealthy obesity (MUO). METHODS: Cross-sectional data of 9270 obese individuals (30-69 years) of the Lifelines Cohort Study was used. MHO was defined as obesity and no metabolic syndrome risk factors and no cardiovascular disease history...
February 12, 2018: Nutrition Journal
https://www.readbyqxmd.com/read/29387454/whole-genome-transcriptomic-insights-into-protective-molecular-mechanisms-in-metabolically-healthy-obese-african-americans
#4
Amadou Gaye, Ayo P Doumatey, Sharon K Davis, Charles N Rotimi, Gary H Gibbons
Several clinical guidelines have been proposed to distinguish metabolically healthy obesity (MHO) from other subgroups of obesity but the molecular mechanisms by which MHO individuals remain metabolically healthy despite having a high fat mass are yet to be elucidated. We conducted the first whole blood transcriptomic study designed to identify specific sets of genes that might shed novel insights into the molecular mechanisms that protect or delay the occurrence of obesity-related co-morbidities in MHO. The study included 29 African-American obese individuals, 8 MHO and 21 metabolically abnormal obese (MAO)...
2018: NPJ Genomic Medicine
https://www.readbyqxmd.com/read/29385682/serum-antioxidant-associations-with-metabolic-characteristics-in-metabolically-healthy-and-unhealthy-adolescents-with-severe-obesity-an-observational-study
#5
Ana Paula Stenzel, Roberta Carvalho, Patricia Jesus, Aline Bull, Silvia Pereira, Carlos Saboya, Andrea Ramalho
Considering the inadequacy of some antioxidant nutrients in severely obese adolescents, this study aimed to assess the relationship between antioxidant micronutrients status and metabolic syndrome components in metabolically healthy obesity (MHO) and unhealthy obesity (MUO). We performed an observational study in severely obese adolescents (body mass index > 99th percentile) and they were classified into MHO or MUO, according to the criteria adapted for adolescents. Anthropometric, biochemical, and clinical variables were analyzed to characterize the sample of adolescents...
January 30, 2018: Nutrients
https://www.readbyqxmd.com/read/29381992/the-prevalence-metabolic-risk-and-effects-of-lifestyle-intervention-for-metabolically-healthy-obesity-a-systematic-review-and-meta-analysis-a-prisma-compliant-article
#6
Hanli Lin, Liqun Zhang, Ruizhi Zheng, Yishan Zheng
BACKGROUND: We conducted a systematic review and meta-analysis to firstly obtain a reliable estimation of the prevalence of metabolically healthy obese (MHO) individuals in obesity, then assessed the risk of developing metabolic abnormalities (MA) among MHO individuals. At last, we evaluated the effects of traditional lifestyle interventions on metabolic level for MHO subjects. METHODS: A systematic review and meta-analysis (PRISMA) guideline were conducted, and original studies were searched up to December 31, 2016...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29365865/implication-of-the-mediterranean-diet-and-physical-exercise-on-the-lipid-profile-based-on-1h-nmr-spectroscopy-of-metabolically-healthy-obese-women-mho
#7
Enrique Rodríguez-García, Josefina Ruiz-Nava, Sonia Santamaria-Fernandez, Jose Carlos Fernández-Garcia, Antonio Vargas Candela, Raquel Yahyaoui, Francisco Tinahones, Maria Rosa Bernal-Lopez, Ricardo Gomez-Huelgas
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29342196/low-fitness-is-associated-with-abdominal-adiposity-and-low-grade-inflammation-independent-of-bmi
#8
Anne-Sophie Wedell-Neergaard, Louise Eriksen, Morten Grønbæk, Bente Klarlund Pedersen, Rikke Krogh-Madsen, Janne Tolstrup
OBJECTIVE: Up to 30% of obese individuals are metabolically healthy. Metabolically healthy obese (MHO) individuals are characterized by having low abdominal adiposity, low inflammation level and low risk of developing metabolic comorbidity. In this study, we hypothesize that cardiorespiratory fitness (fitness) is a determinant factor for the MHO individuals and aim to investigate the associations between fitness, abdominal adiposity and low-grade inflammation within different BMI categories...
2018: PloS One
https://www.readbyqxmd.com/read/29341865/evidence-of-genetic-predisposition-for-metabolically-healthy-obesity-and-metabolically-obese-normal-weight
#9
Lam Opal Huang, Ruth Loos, Tuomas Oskari Kilpeläinen
Obesity has evolved into a global pandemic, which constitutes a major threat to public health. The majority of obesity-related health care costs are due to cardiometabolic complications, such as insulin resistance, dyslipidemia, and hypertension, which are risk factors for type 2 diabetes and cardiovascular disease. However, many obese individuals, often called metabolically healthy obese (MHO), seem to be protected from these cardiometabolic complications. Conversely, there is a group of individuals who suffer from cardiometabolic complications despite being of normal weight; a condition termed metabolically obese normal weight (MONW)...
December 20, 2017: Physiological Genomics
https://www.readbyqxmd.com/read/29320714/a-case-report-of-mesenteric-heterotopic-ossification-histopathologic-and-genetic-findings
#10
REVIEW
Matthew Amalfitano, Billie Fyfe, Sumi V Thomas, Kevin P Egan, Meiqi Xu, Andrew G Smith, Frederick S Kaplan, Eileen M Shore, Robert J Pignolo
Mesenteric heterotopic ossification (MHO) is very rare and occurs in mid- to late-adulthood, usually in the context of prior abdominal surgery. The mechanisms of MHO are unknown. Here we describe the case of a 72-year-old man with MHO. Standard histological staining revealed that MHO occurred through an endochondral process. By comparison to known mutations in genetic conditions of HO such as fibrodysplasia ossificans progressiva (FOP) and progressive osseous heteroplasia (POH), DNA sequencing analysis demonstrated the presence of a commonly occurring heterozygous synonymous polymorphism (c...
January 7, 2018: Bone
https://www.readbyqxmd.com/read/29319402/interaction-of-metabolic-health-and-obesity-on-subclinical-target-organ-damage
#11
Hyun-Jung Lee, Hack-Lyoung Kim, Jaehoon Chung, Woo-Hyun Lim, Jae-Bin Seo, Sang-Hyun Kim, Joo-Hee Zo, Myung-A Kim
BACKGROUND: Metabolically healthy obese (MHO) individuals generally show better cardiovascular prognosis compared with metabolically unhealthy counterparts, which may be related to different patterns of target organ damage (TOD). We aimed to investigate the patterns of TOD related to obesity and metabolic unhealthiness. METHODS: A total of 659 Korean adults (mean age, 60.0 ± 11.8 years; male, 51.1%) undergoing health examinations were stratified into four groups according to obesity (body mass index ≥25...
February 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29284058/metabolically-healthy-obese-individuals-present-similar-chronic-inflammation-level-but-less-insulin-resistance-than-obese-individuals-with-metabolic-syndrome
#12
Andrea Elena Iglesias Molli, Alberto Penas Steinhardt, Ariel Pablo López, Claudio Daniel González, Jorge Vilariño, Gustavo Daniel Frechtel, Gloria Edith Cerrone
The Metabolic Syndrome (MetS) is a cluster of cardiometabolic risk factors, usually accompanied by the presence of insulin resistance (IR) and a systemic subclinical inflammation state. Metabolically healthy obese (MHO) individuals seem to be protected against cardiometabolic complications. The aim of this work was to characterize phenotypically the low-grade inflammation and the IR in MHO individuals in comparison to obese individuals with MetS and control non obese. We studied two different populations: 940 individuals from the general population of Buenos Aires and 518 individuals from the general population of Venado Tuerto; grouped in three groups: metabolically healthy non-obese individuals (MHNO), MHO and obese individuals with MetS (MSO)...
2017: PloS One
https://www.readbyqxmd.com/read/29246653/myostatin-and-adipokines-the-role-of-the-metabolically-unhealthy-obese-phenotype-in-muscle-function-and-aerobic-capacity-in-young-adults
#13
Lívia Pinheiro Carvalho, Renata Pedrolongo Basso-Vanelli, Luciana Di Thommazo-Luporini, Renata Gonçalves Mendes, Manoel Carneiro Oliveira-Junior, Rodolfo de Paula Vieira, José Carlos Bonjorno-Junior, Cláudio Ricardo Oliveira, Rafael Luporini, Audrey Borghi-Silva
Obesity is often associated with metabolic disorders. However, some obese people can present a metabolically healthy phenotype, despite having excessive body fat. Obesity-related cytokines, such as myostatin (MSTN), leptin (LP) and adiponectin (ADP) appear to be key factors for the regulation of muscle and energy metabolism. Our aim was to compare lipid, glucose-insulin and inflammatory (tumor necrosis factor alpha; TNF-α) profiles, muscle function, energy expenditure and aerobic capacity between healthy normal-weight (NW) adults, metabolically healthy obese (MHO) and metabolically unhealthy obese (MUHO) adults; to study the associations between these outcomes and the cytokines MSTN, ADP, LP; and to establish cutoffs for MSTN and LP/ADP to identify the MUHO phenotype...
December 12, 2017: Cytokine
https://www.readbyqxmd.com/read/29238351/natural-killer-cell-activity-and-interleukin-12-in-metabolically-healthy-versus-metabolically-unhealthy-overweight-individuals
#14
Minjoo Kim, Minkyung Kim, Hye Jin Yoo, Jong Ho Lee
The purpose of this study was to determine whether the immune system is involved in the different metabolic circumstances in healthy and unhealthy overweight individuals. We examined the metabolic and immune characteristics of 117 overweight individuals. Subjects were classified as metabolically healthy overweight (MHO, n = 72) or metabolically unhealthy overweight (MUO, n = 45). The immune response was measured by circulating levels of natural killer (NK) cell activity and cytokines. Both groups were comparable with regards to age, sex distribution, smoking and drinking status, and body mass index...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29234514/mental-capacity-act-northern-ireland-2016
#15
REVIEW
Gerard Lynch, Catherine Taggart, Philip Campbell
Mental health legislation in Northern Ireland has always been separate from legislation in the rest of the UK; the Mental Health (Northern Ireland) Order (MHO) had been in place since 1986. In common with other jurisdictions, this legislation utilises the presence of mental disorder and risk as criteria for detention and involuntary treatment. The MHO has been replaced by the Mental Capacity Act (Northern Ireland) 2016 (MCA), an example of 'fusion' legislation in which impairment of decision-making capacity and best interests are the only criteria to be used when making decisions across health and social care...
December 2017: BJPsych Bulletin
https://www.readbyqxmd.com/read/29217969/severity-of-hyperoxia-as-a-risk-factor-in-patients-undergoing-on-pump-cardiac-surgery
#16
Gabrielius Jakutis, Ieva Norkienė, Donata Ringaitienė, Tomas Jovaiša
Background: Hyperoxia has long been perceived as a desirable or at least an inevitable part of cardiopulmonary bypass. Recent evidence suggest that it might have multiple detrimental effects on patient homeostasis. The aim of the study was to identify the determinants of supra-physiological values of partial oxygen pressure during on-pump cardiac surgery and to assess the impact of hyperoxia on clinical outcomes. Materials and methods: Retrospective data analysis of the institutional research database was performed to evaluate the effects of hyperoxia in patients undergoing elective cardiac surgery with cardiopulmonary bypass, 246 patients were included in the final analysis...
2017: Acta Medica Lituanica
https://www.readbyqxmd.com/read/29196231/metabolically-healthy-obese-and-unhealthy-normal-weight-in-iranian-adult-population-prevalence-and-the-associated-factors
#17
Karimollah Hajian-Tilaki, Behzad Heidari
AIMS: The objective of this study was to determine the prevalence and the associated factors of metabolically unhealthy in normal-weight and metabolically healthy in obese. METHODS: We analyzed the data of a representative sample of 986 participants recruited among adult population of north of Iran. Data were collected regarding demographic characteristics, lifestyle, body mass index, abdominal obesity measures, blood pressure, and lipid profiles. The participants were classified as metabolically healthy obese (MHO) and metabolically unhealthy normal-weight (MUNW)...
November 23, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29177259/the-influence-of-adipose-tissue-volume-can-significantly-affect-the-metabolic-activity-of-reference-organs-in-18f-fdg-pet-ct-studies-of-a-normal-healthy-population
#18
Ik Dong Yoo, Sang Mi Lee, Jeong Won Lee, Jung Eun Oh, Yong Jin Cho, Hwang Sik Shin
OBJECTIVE: This study investigated whether fluorine-18-fluorodeoxyglucose (18F-FDG) uptake of reference organs can be affected by subjects' factors in positron emission tomography/computed tomography (PET/CT) in a healthy population. SUBJECTS AND METHODS: A total of 208 normal healthy subjects without diabetes or dyslipidemia were included. Adipose tissue volume was measured by CT images from a dedicated PET/CT scan. Uptake of 18F-FDG of reference organs was measured from liver, blood pool, and muscle, and was normalized by lean body anthropometric data and adipose tissue volume...
November 27, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29100915/dynamic-status-of-metabolically-healthy-overweight-obesity-and-metabolically-unhealthy-and-normal-weight-and-the-risk-of-type-2-diabetes-mellitus-a-cohort-study-of-a-rural-adult-chinese-population
#19
Bingyuan Wang, Ming Zhang, Shu Wang, Chongjian Wang, Jinjin Wang, Linlin Li, Lu Zhang, Yongcheng Ren, Chengyi Han, Yang Zhao, Junmei Zhou, Guo'an Wang, Yanxia Shen, Dongting Wu, Chao Pang, Lei Yin, Tianping Feng, Jingzhi Zhao, Xinping Luo, Dongsheng Hu
OBJECTIVE: We aimed to determine dynamic status of metabolically healthy overweight or obesity (MHO) and metabolically unhealthy and normal weight (MUNW) and the risk of incident type 2 diabetes mellitus (T2DM). METHODS: Body mass index and metabolic health were assessed on 11,865 eligible participants ≥18 years from 6-year follow-up cohort study of a rural Chinese population. Participants were classified as metabolically healthy and normal weight (MHNW), MHO, MUNW and metabolically unhealthy overweight or obesity (MUO) at both baseline and follow-up examinations...
October 31, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/29093301/adipokines-are-associated-with-hypertension-in-metabolically-healthy-obese-mho-children-and-adolescents-a-prospective-population-based-cohort-study
#20
Wenqing Ding, Hong Cheng, Fangfang Chen, Yinkun Yan, Meixian Zhang, Xiaoyuan Zhao, Dongqing Hou, Jie Mi
BACKGROUND: The potential mechanism underlying the relationship between the risk of cardiovascular diseases and metabolically healthy obese (MHO) individuals remains unclear. The aim of the study was to prospectively investigate the potential role of the adipokines in the association between the MHO phenotype and hypertension in children and adolescents. METHODS: A total of 1184 participants at baseline were recruited from a cohort of the Beijing Child and Adolescent Metabolic Syndrome (BCAMS) study...
October 25, 2017: Journal of Epidemiology
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