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https://www.readbyqxmd.com/read/28644850/visceral-adiposity-index-predicts-the-conversion-of-metabolically-healthy-obesity-to-an-unhealthy-phenotype
#1
Yu Mi Kang, Chang Hee Jung, Yun Kyung Cho, Jung Eun Jang, Jenie Yoonoo Hwang, Eun Hee Kim, Woo Je Lee, Joong-Yeol Park, Hong-Kyu Kim
OBJECTIVE: Some individuals with metabolically healthy obesity (MHO) convert to metabolically unhealthy obesity (MUO) phenotype, and visceral adiposity is one of proposed mechanisms underlying such conversion. Visceral adipose index (VAI) is a novel mathematical model which estimates visceral adiposity based on anthropometric and lipid profiles. We aimed to determine the association of VAI-estimated visceral adiposity with the MHO-to-MUO conversion and the predictive value of VAI in estimating such unfavorable outcomes...
2017: PloS One
https://www.readbyqxmd.com/read/28636624/metabolically-healthy-obesity-is-associated-with-higher-prevalence-of-colorectal-adenoma
#2
Dong Hyun Sinn, Yang Won Min, Hee Jung Son, Poong-Lyul Rhee, Seung Woon Paik, Sung Noh Hong, Geum-Youn Gwak
BACKGROUND: The risk of colorectal adenoma (CRA), an important precursor of colorectal cancer, is largely unknown among obese individuals without obesity-related metabolic abnormalities, a condition described as metabolically-healthy obese (MHO). The aim of this study was to examine the association among metabolic status, the different categories of body mass index (BMI), and CRA in a large cohort of adults. METHODS: We analyzed the association among metabolic status, BMI categories and CRA in asymptomatic adults who underwent a first-time colonoscopy as part of the comprehensive health check-up program at the Health Promotion Center of Samsung Medical Center, from January 2005 to December 2012...
2017: PloS One
https://www.readbyqxmd.com/read/28630460/oxidative-and-endoplasmic-reticulum-stress-is-impaired-in-leukocytes-from-metabolically-unhealthy-vs-healthy-obese-individuals
#3
C Bañuls, S Rovira-Llopis, S Lopez-Domenech, N Diaz-Morales, A Blas-Garcia, S Veses, C Morillas, V M Victor, M Rocha, A Hernandez-Mijares
BACKGROUND: Oxidative stress and inflammation are related to obesity, but the influence of metabolic disturbances on these parameters and their relationship with endoplasmic reticulum (ER) stress is unknown. Therefore, this study was performed to evaluate whether metabolic profile influences ER and oxidative stress in an obese population with/without comorbidities. SUBJECTS AND METHODS: A total of 113 obese patients were enrolled in the study; 29 were metabolically healthy (MHO), 53 were metabolically abnormal (MAO), and 31 had type 2 diabetes (MADO)...
June 20, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28614006/fat-free-mass-metabolically-healthy-obesity-and-type-2-diabetes-in-severely-obese-asian-adults
#4
Pornpoj Pramyothin, Vichol Limpattanachart, Suwitcha Dawilai, Rungnapa Sarasak, Chariya Sukaruttanawong, Kusuma Chaiyasoot, Songsri Keawtanom, Preyanuj Yamwong
OBJECTIVE: To determine whether fat-free mass (FFM) is independently associated with the metabolically healthy obesity (MHO) phenotype, the metabolic syndrome (MS), and type 2 diabetes (T2D) in obese Asian adults. METHODS: Obese patients (BMI ≥25 kg/m(2)) seeking weight management at an academic medical center from 2007-2016 were included. FFM was measured by bioelectrical impedance. RESULTS: Of the 552 patients (67.0% female, median age 40...
June 14, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28602062/metabolically-healthy-obesity-a-friend-or-foe
#5
Chang Hee Jung, Woo Je Lee, Kee-Ho Song
Obesity is associated with a reduced life expectancy, largely because obese individuals are at an increased risk of type 2 diabetes, cardiovascular disease, and several types of cancer. Much interest has recently focused on the concept of "all obesity is not created equally." Obese individuals without the metabolic abnormalities that commonly accompany excess adiposity, a condition known as metabolically healthy obesity (MHO), account for a substantial proportion of the obese adult population. Numerous possible mechanisms underlying MHO have been suggested, including adipose tissue distribution and inflammation...
June 5, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28601090/physical-health-related-quality-of-life-in-relation-to-metabolic-health-and-obesity-among-men-and-women-in-germany
#6
Julia Truthmann, Gert B M Mensink, Anja Bosy-Westphal, Ulfert Hapke, Christa Scheidt-Nave, Anja Schienkiewitz
BACKGROUND: This study examined sex-specific differences in physical health-related quality of life (HRQoL) across subgroups of metabolic health and obesity. We specifically asked whether (1) obesity is related to lower HRQoL independent of metabolic health status and potential confounders, and (2) whether associations are similar in men and women. METHODS: We used cross-sectional data from the German Health Interview and Examination Survey 2008-11. Physical HRQoL was measured using the Short Form-36 version 2 physical component summary (PCS) score...
June 10, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28575097/influence-of-the-definition-of-metabolically-healthy-obesity-on-the-progression-of-coronary-artery-calcification
#7
Ji Won Yoon, Chan-Hyeon Jung, Min-Kyung Kim, Hyo Eun Park, Kyong Soo Park, Hak Chul Jang, Min Kyong Moon, Su-Yeon Choi, Bo Kyung Koo
OBJECTIVES: Debates whether metabolically healthy obesity (MHO) increases the cardiovascular risk might be due to the metabolic instability of MHO or the absence of a perfect definition of MHO. Therefore, we aimed to investigate the influence of the MHO phenotype on the coronary artery calcium score (CACS) progression according to definition of MHO. METHODS: We analyzed a retrospective cohort with a CACS of 0 at baseline and available serial CACS measurements taken ≥ 12 months apart (n = 1,218)...
2017: PloS One
https://www.readbyqxmd.com/read/28570654/haplotypes-on-pig-chromosome-3-distinguish-metabolically-healthy-from-unhealthy-obese-individuals
#8
Simona D Frederiksen, Peter Karlskov-Mortensen, Sameer D Pant, Maryse Guerin, Philippe Lesnik, Claus B Jørgensen, Susanna Cirera, Camilla S Bruun, Thomas Mark, Merete Fredholm
We have established a pig resource population specifically designed to elucidate the genetics involved in development of obesity and obesity related co-morbidities by crossing the obesity prone Göttingen Minipig breed with two lean production pig breeds. In this study we have performed genome wide association (GWA) to identify loci with effect on blood lipid levels. The most significantly associated single nucleotide polymorphisms (SNPs) were used for linkage disequilibrium (LD) and haplotype analyses. Three separate haploblocks which influence the ratio between high density lipoprotein cholesterol and total cholesterol (HDL-C/CT), triglycerides (TG) and low density lipoprotein cholesterol (LDL-C) levels respectively were identified on Sus Scrofa chromosome 3 (SSC3)...
2017: PloS One
https://www.readbyqxmd.com/read/28564650/the-metabolic-phenotype-in-obesity-fat-mass-body-fat-distribution-and-adipose-tissue-function
#9
Gijs H Goossens
The current obesity epidemic poses a major public health issue since obesity predisposes towards several chronic diseases. BMI and total adiposity are positively correlated with cardiometabolic disease risk at the population level. However, body fat distribution and an impaired adipose tissue function, rather than total fat mass, better predict insulin resistance and related complications at the individual level. Adipose tissue dysfunction is determined by an impaired adipose tissue expandability, adipocyte hypertrophy, altered lipid metabolism, and local inflammation...
June 1, 2017: Obesity Facts
https://www.readbyqxmd.com/read/28559291/interaction-of-mycoplasma-hominis-pg21-with-human-dendritic-cells-il-23-inducing-mycoplasmal-lipoproteins-and-inflammasome-activation-of-the-cell
#10
J Goret, L Béven, B Faustin, C Contin-Bordes, C Le Roy, S Claverol, H Renaudin, C Bébéar, S Pereyre
Mycoplasma hominis lacks a cell wall and lipoproteins anchored to the extracellular side of the plasma membrane are in direct contact with the host components. A Triton X-114 extract of M. hominis enriched with lipoproteins was shown to stimulate the production of IL-23 by human dendritic cells (hDCs). The inflammasome activation of the host cell has never been reported upon M. hominis infection. We studied here the interaction between M. hominis PG21 and hDCs by analyzing both the inflammation-inducing mycoplasmal lipoproteins and the inflammasome activation of the host cell...
May 30, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28554164/association-between-obesity-phenotypes-and-incident-hypertension-among-chinese-adults-a%C3%A2-prospective-cohort-study
#11
Z K Cao, Y Huang, H J Yu, S Yuan, B W Tang, Q X Li, X T Li, X H Yang, Q Q He
OBJECTIVES: To explore the association between obesity phenotype and the risk of hypertension among Chinese adults. STUDY DESIGN: A prospective cohort study. METHODS: Two waves of data were collected in 2009 and 2011 by the China Health Nutrition Survey. According to International Diabetes Federation and Chinese obesity criteria, participants were divided into four groups: metabolically healthy non-overweight/obesity (MHNO), metabolically healthy overweight/obesity (MHO), metabolically abnormal non-overweight/obesity (MANO), and metabolically abnormal overweight/obesity (MAO)...
May 26, 2017: Public Health
https://www.readbyqxmd.com/read/28510711/obesity-and-metabolic-unhealthiness-have-different-effects-on-colorectal-neoplasms
#12
Sun-Hye Ko, Myong Ki Baeg, Seung Yeon Ko, Hee Sun Jung, Pumsoo Kim, Myung-Gyu Choi
Context: Metabolic factors such as obesity and insulin resistance have been suggested as risk factors for colorectal neoplasms (CRN), but few studies have investigated the associations between metabolic status, obesity, and CRN. Objective: To investigate the relationship between metabolic status, obesity and CRN in Koreans who underwent colonoscopy during health screening. Design: Retrospective, cross-sectional. Participants: Subjects were divided into four groups based on metabolic and obesity criteria, (1) metabolically healthy nonobese (MHNO), (2) metabolically healthy obese (MHO), (3) metabolically unhealthy nonobese (MUNO), and (4) metabolically unhealthy obese (MUO)...
May 15, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28486932/risk-assessment-of-manual-handling-operations-at-work-with-the-key-indicator-method-kim-mho-determination-of-criterion-validity-regarding-the-prevalence-of-musculoskeletal-symptoms-and-clinical-conditions-within-a-cross-sectional-study
#13
Andre Klussmann, Falk Liebers, Hansjürgen Gebhardt, Monika A Rieger, Ute Latza, Ulf Steinberg
BACKGROUND: Manual handling operations (MHO) are known to be risk factors for work-related upper limb disorders (WRULDs), e.g. symptoms and conditions such as carpal tunnel syndrome. To estimate the risk of WRULDs, a Key Indicator Method (KIM) for the risk assessment of MHO was developed. The method was validated in regard to different criteria, including face validity, criterion validity, reliability and further aspects concerning utility. This paper describes the KIM-MHO and criterion validity of this method with reference to prevalence of musculoskeletal disorders (MSDs)...
May 10, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28473926/apolipoproteins-a-i-b-and-c-iii-and-obesity-in-young-adult-cherokee
#14
Wenyu Wang, Piers Blackett, Sohail Khan, Elisa Lee
Since young adult Cherokee are at increased risk for both diabetes and cardiovascular disease, we assessed association of apolipoproteins (A-I, B, and C-III in non-HDL and HDL) with obesity and related risk factors. Obese participants (BMI ≥ 30) aged 20-40 years (n = 476) were studied. Metabolically healthy obese (MHO) individuals were defined as not having any of four components of the ATP-III metabolic syndrome after exclusion of waist circumference, and obese participants not being MHO were defined as metabolically abnormal obese (MAO)...
2017: Journal of Lipids
https://www.readbyqxmd.com/read/28419118/fatty-liver-disease-determines-the-progression-of-coronary-artery-calcification-in-a-metabolically-healthy-obese-population
#15
Yu Mi Kang, Chang Hee Jung, Yun Kyung Cho, Seung Eun Lee, Min Jung Lee, Jenie Yoonoo Hwang, Eun Hee Kim, Joong-Yeol Park, Woo Je Lee, Hong-Kyu Kim
OBJECTIVES: Metabolically healthy obese (MHO) phenotype describes an obese state with a favorable metabolic profile. However, the prognosis of this subpopulation remains controversial. We aimed to examine whether MHO phenotype is associated with progression of atherosclerotic activity, reflected as the changes in coronary artery calcification (CAC) over time. If so, we sought to determine the role of fatty liver disease (FLD), the hallmark of hepatic steatosis, in this progression. METHODS: We enrolled 1,240 asymptomatic subjects who underwent repeated CAC score measurement during routine health examinations...
2017: PloS One
https://www.readbyqxmd.com/read/28404516/risk-of-diabetes-according-to-the-metabolic-health-status-and-degree-of-obesity
#16
Mohsen Janghorbani, Mohammad Reza Salamat, Masoud Amini, Ashraf Aminorroaya
AIM: To determine the progression rates from metabolically healthy or unhealthy normal weight, overweight and obese phenotype to type 2 diabetes (T2D) in a non-diabetic high risk population in Isfahan, Iran. METHODS: T2D incidence during a mean (SD) follow-up of 10.1 (2.3) years was examined among 1,982 non-diabetic first-degree relatives (FDR) of patients with T2D 30-70 years old. Participants were divided into 6 groups based on body mass index and metabolic syndrome component, except waist circumference, at baseline: metabolically healthy normal weight (MHNW), metabolically healthy overweight (MHOW), metabolically healthy obese (MHO), metabolically unhealthy normal weight (MUNW), metabolically unhealthy overweight (MUOW) and metabolically unhealthy obese (MUO)...
April 1, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28385392/metabolically-healthy-obesity-and-the-risk-for-subclinical-atherosclerosis
#17
Tae Jun Kim, Hee-Young Shin, Yoosoo Chang, Mira Kang, Jaehwan Jee, Yoon-Ho Choi, Hyeon Seon Ahn, Soo Hyun Ahn, Hee Jung Son, Seungho Ryu
BACKGROUND AND AIMS: Although obesity and metabolic abnormalities are known risk factors for cardiovascular disease, the risk of cardiovascular disease among obese individuals without obesity-related metabolic abnormalities, referred to as metabolically healthy obese (MHO), remains unclear. We examined the association between body mass index categories and the development of subclinical carotid atherosclerosis in a cohort of metabolically healthy individuals. METHODS: We conducted a cohort study of 6453 men without subclinical carotid atherosclerosis or metabolic abnormalities at baseline, who underwent repeated health check-up examinations that included carotid ultrasound...
March 28, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28385358/atrial-fibrillation-risk-in-metabolically-healthy-obesity-a-nationwide-population-based-study
#18
HyunJung Lee, Eue-Keun Choi, Seung-Hwan Lee, Kyung-Do Han, Tae-Min Rhee, Chan-Soon Park, So-Ryoung Lee, Won-Seok Choe, Woo-Hyun Lim, Si-Hyuck Kang, Myung-Jin Cha, Seil Oh
BACKGROUND: Metabolically healthy obese (MHO) individuals are reported to have a marginal increase in cardiovascular risk; however, their atrial fibrillation (AF) risk is unclear. We aimed to assess AF risk in MHO individuals and identify whether AF development is associated with obesity or influenced by metabolic comorbidities. METHODS: A retrospective cohort of 389,321 individuals (age, 45.6±14.5years; male, 52.1%) was extracted from the Korean National Health Insurance sample database between 2004 and 2006 and followed-up for new-onset AF until 2013...
March 28, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28384340/parathyroid-hormone-and-vitamin-d-are-associated-with-the-risk-of-metabolic-obesity-in-a-middle-aged-and-older-korean-population-with-preserved-renal-function-a-cross-sectional-study
#19
Jeonghoon Ha, Kwanhoon Jo, Dong-Jun Lim, Jung-Min Lee, Sang-Ah Chang, Moo I L Kang, Bong Yun Cha, Min-Hee Kim
BACKGROUND: In general, obesity is a major contributor to metabolic syndrome (MetS) and is associated with insulin resistance (IR). Metabolically obese but normal weight (MONW) individuals present metabolic abnormalities and features of MetS despite having a normal range of body mass index (BMI). In recent years, different subtypes of obesity have been introduced, including metabolically healthy obese (MHO) and metabolically obese obese (MOO). Also, it has been reported that vitamin D and parathyroid hormone (PTH) are possibly linked with MetS...
2017: PloS One
https://www.readbyqxmd.com/read/28384219/metabolically-healthy-obesity-and-depressive-symptoms-16-year-follow-up-of-the-gazel-cohort-study
#20
Guy-Marino Hinnouho, Archana Singh-Manoux, Alice Gueguen, Joane Matta, Cedric Lemogne, Marcel Goldberg, Marie Zins, Sébastien Czernichow
AIMS: The health correlates of the metabolically healthy obese (MHO) phenotype, particularly in relation to depressive symptoms remains unclear. Accordingly, we examined the risk of depressive symptoms in this phenotype using a 16-year follow-up prospective study. METHODS: A sample of 14 475 participants (75% men), aged 44-59 years in 1996, was drawn from the Gazel cohort. Obesity was defined as body mass index (BMI) ≥ 30 kg/m2 and metabolic health as having none of the self-reported following cardiovascular risk factors: hypertension, type 2 diabetes and dyslipidemia...
2017: PloS One
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