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https://www.readbyqxmd.com/read/28419118/fatty-liver-disease-determines-the-progression-of-coronary-artery-calcification-in-a-metabolically-healthy-obese-population
#1
Yu Mi Kang, Chang Hee Jung, Yun Kyung Cho, Seung Eun Lee, Min Jung Lee, Jenie Yoonoo Hwang, Eun Hee Kim, Joong-Yeol Park, Woo Je Lee, Hong-Kyu Kim
OBJECTIVES: Metabolically healthy obese (MHO) phenotype describes an obese state with a favorable metabolic profile. However, the prognosis of this subpopulation remains controversial. We aimed to examine whether MHO phenotype is associated with progression of atherosclerotic activity, reflected as the changes in coronary artery calcification (CAC) over time. If so, we sought to determine the role of fatty liver disease (FLD), the hallmark of hepatic steatosis, in this progression. METHODS: We enrolled 1,240 asymptomatic subjects who underwent repeated CAC score measurement during routine health examinations...
2017: PloS One
https://www.readbyqxmd.com/read/28404516/risk-of-diabetes-according-to-the-metabolic-health-status-and-degree-of-obesity
#2
Mohsen Janghorbani, Mohammad Reza Salamat, Masoud Amini, Ashraf Aminorroaya
AIM: To determine the progression rates from metabolically healthy or unhealthy normal weight, overweight and obese phenotype to type 2 diabetes (T2D) in a non-diabetic high risk population in Isfahan, Iran. METHODS: T2D incidence during a mean (SD) follow-up of 10.1 (2.3) years was examined among 1,982 non-diabetic first-degree relatives (FDR) of patients with T2D 30-70 years old. Participants were divided into 6 groups based on body mass index and metabolic syndrome component, except waist circumference, at baseline: metabolically healthy normal weight (MHNW), metabolically healthy overweight (MHOW), metabolically healthy obese (MHO), metabolically unhealthy normal weight (MUNW), metabolically unhealthy overweight (MUOW) and metabolically unhealthy obese (MUO)...
April 1, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28385392/metabolically-healthy-obesity-and-the-risk-for-subclinical-atherosclerosis
#3
Tae Jun Kim, Hee-Young Shin, Yoosoo Chang, Mira Kang, Jaehwan Jee, Yoon-Ho Choi, Hyeon Seon Ahn, Soo Hyun Ahn, Hee Jung Son, Seungho Ryu
BACKGROUND AND AIMS: Although obesity and metabolic abnormalities are known risk factors for cardiovascular disease, the risk of cardiovascular disease among obese individuals without obesity-related metabolic abnormalities, referred to as metabolically healthy obese (MHO), remains unclear. We examined the association between body mass index categories and the development of subclinical carotid atherosclerosis in a cohort of metabolically healthy individuals. METHODS: We conducted a cohort study of 6453 men without subclinical carotid atherosclerosis or metabolic abnormalities at baseline, who underwent repeated health check-up examinations that included carotid ultrasound...
March 28, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28385358/atrial-fibrillation-risk-in-metabolically-healthy-obesity-a-nationwide-population-based-study
#4
HyunJung Lee, Eue-Keun Choi, Seung-Hwan Lee, Kyung-Do Han, Tae-Min Rhee, Chan-Soon Park, So-Ryoung Lee, Won-Seok Choe, Woo-Hyun Lim, Si-Hyuck Kang, Myung-Jin Cha, Seil Oh
BACKGROUND: Metabolically healthy obese (MHO) individuals are reported to have a marginal increase in cardiovascular risk; however, their atrial fibrillation (AF) risk is unclear. We aimed to assess AF risk in MHO individuals and identify whether AF development is associated with obesity or influenced by metabolic comorbidities. METHODS: A retrospective cohort of 389,321 individuals (age, 45.6±14.5years; male, 52.1%) was extracted from the Korean National Health Insurance sample database between 2004 and 2006 and followed-up for new-onset AF until 2013...
March 28, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28384340/parathyroid-hormone-and-vitamin-d-are-associated-with-the-risk-of-metabolic-obesity-in-a-middle-aged-and-older-korean-population-with-preserved-renal-function-a-cross-sectional-study
#5
Jeonghoon Ha, Kwanhoon Jo, Dong-Jun Lim, Jung-Min Lee, Sang-Ah Chang, Moo I L Kang, Bong Yun Cha, Min-Hee Kim
BACKGROUND: In general, obesity is a major contributor to metabolic syndrome (MetS) and is associated with insulin resistance (IR). Metabolically obese but normal weight (MONW) individuals present metabolic abnormalities and features of MetS despite having a normal range of body mass index (BMI). In recent years, different subtypes of obesity have been introduced, including metabolically healthy obese (MHO) and metabolically obese obese (MOO). Also, it has been reported that vitamin D and parathyroid hormone (PTH) are possibly linked with MetS...
2017: PloS One
https://www.readbyqxmd.com/read/28384219/metabolically-healthy-obesity-and-depressive-symptoms-16-year-follow-up-of-the-gazel-cohort-study
#6
Guy-Marino Hinnouho, Archana Singh-Manoux, Alice Gueguen, Joane Matta, Cedric Lemogne, Marcel Goldberg, Marie Zins, Sébastien Czernichow
AIMS: The health correlates of the metabolically healthy obese (MHO) phenotype, particularly in relation to depressive symptoms remains unclear. Accordingly, we examined the risk of depressive symptoms in this phenotype using a 16-year follow-up prospective study. METHODS: A sample of 14 475 participants (75% men), aged 44-59 years in 1996, was drawn from the Gazel cohort. Obesity was defined as body mass index (BMI) ≥ 30 kg/m2 and metabolic health as having none of the self-reported following cardiovascular risk factors: hypertension, type 2 diabetes and dyslipidemia...
2017: PloS One
https://www.readbyqxmd.com/read/28384193/metabolically-healthy-obese-women-have-longer-telomere-length-than-obese-women-with-metabolic-syndrome
#7
Andrea E Iglesias Molli, Julieta Panero, Patricia C Dos Santos, Claudio D González, Jorge Vilariño, Marta Sereday, Gloria E Cerrone, Irma Slavutsky, Gustavo D Frechtel
INTRODUCTION: Obesity is the principal component in the Metabolic Syndrome (MetS) that determines the progression of metabolic complications. Metabolically healthy obese (MHO) individuals seem to be protected against those complications. Telomere length (TL) as a novel marker of cellular aging had a complex relationship to the MetS. The principal aim of this study was to investigate the TL in MHO, and to study the association between TL and the worsening of the metabolic condition. MATERIAL AND METHODS: We have determined the absolute TL (aTL) in 400 women (mean age of 46...
2017: PloS One
https://www.readbyqxmd.com/read/28367325/association-between-sleep-habits-and-metabolically-healthy-obesity-in-adults-a-cross-sectional-study
#8
Thirumagal Kanagasabai, Ramandeep Dhanoa, Jennifer L Kuk, Chris I Ardern
Higher body mass index (BMI) increases the risk of cardiometabolic diseases, but nearly a third of the people living with obesity (BMI: ≥30 kg/m(2)) are metabolically healthy (MHO). Extreme sleep durations and poor sleep quality are associated with higher bodyweight and cardiometabolic dysfunction, but the full extent to which sleep habits may help differentiate those with MHO versus metabolically abnormal obesity (MAO) is not yet known. Data from the U.S. National Health and Nutritional Examination Survey 2005-08 was used (BMI: ≥30 kg/m(2); ≥20 y; N = 1,777)...
2017: Journal of Obesity
https://www.readbyqxmd.com/read/28327913/the-use-of-oxford-nanopore-native-barcoding-for-complete-genome-assembly
#9
Sion C Bayliss, Vicky L Hunt, Maho Yokoyama, Harry A Thorpe, Edward J Feil
Background: The Oxford Nanopore Technologies MinION(TM) is a mobile DNA sequencer that can produce long read sequences with a short turn-around time. Here we report the first demonstration of single contig genome assembly using Oxford Nanopore native barcoding when applied to a multiplexed library of 12 samples and combined with existing Illumina short-read data. This paves the way for the closure of multiple bacterial genomes from a single MinION(TM) sequencing run, given the availability of existing short-read data...
February 24, 2017: GigaScience
https://www.readbyqxmd.com/read/28322093/peripheral-invariant-natural-killer-t-cell-deficiency-in-metabolically-unhealthy-but-normal-weight-versus-metabolically-healthy-but-obese-individuals
#10
Xiao-Li Wang, Xiang-Yun Chang, Xiao-Xiao Tang, Zhi-Gang Chen, Ting Zhou, Kan Sun
Objective To investigate the proportion of circulating invariant natural killer T (iNKT) cells in four body health types. Methods In this cross-sectional study, participants were classified into four body health types according to the body mass index and metabolic status: metabolically healthy and normal weight (MHNW), metabolically unhealthy but normal weight (MUNW), metabolically healthy but obese (MHO), or metabolically unhealthy and obese (MUO). Demographic and clinical characteristics were measured, and the homeostasis model assessment of insulin resistance (HOMA-IR) and visceral adiposity index (VAI) were calculated...
December 2016: Journal of International Medical Research
https://www.readbyqxmd.com/read/28318912/less-liver-fibrosis-in-metabolically-healthy-compared-with-metabolically-unhealthy-obese-patients-with-non-alcoholic-fatty-liver-disease
#11
Y Gutiérrez-Grobe, E Juárez-Hernández, B A Sánchez-Jiménez, M H Uribe-Ramos, M H Ramos-Ostos, M Uribe, N C Chávez-Tapia
AIM: This cross-sectional study evaluated liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD), and compared the characteristics of metabolically healthy obese (MHO) with metabolically unhealthy obese (MUHO) patients. METHODS: The study was nested within a randomized clinical trial (RCT) and included obese patients with NAFLD, as determined by liver ultrasonography. Fibrosis was assessed by transient elastography, and AST-to-platelet ratio index (APRI) and NAFLD score...
March 16, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28294315/predictors-of-incident-obesity-phenotype-in-nonobese-healthy-adults
#12
Anita Eftekharzadeh, Golaleh Asghari, Sara Serahati, Farhad Hosseinpanah, Ali Azizi, Maryam Barzin, Parvin Mirmiran, Fereidoun Azizi
BACKGROUND: Despite their different cardiovascular consequences, little is known about predictors of metabolically healthy (MHO) and metabolically unhealthy obesity (MUHO). This cohort study was designed to address this question in participants of the Tehran Lipid and Glucose Study. MATERIALS AND METHODS: Employing the Joint Interim Statement (JIS) metabolic syndrome criteria to define MHO/MUHO phenotypes, nonobese, otherwise healthy individuals, aged > 20 years (n = 3489) were recruited and followed up for a median of 13·4 years...
March 10, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28290879/-adipokines-level-in-metabolically-healthy-obese-saint-petersburg-inhabitants-esse-rf
#13
M A Boyarinova, A V Orlov, O P Rotar, A S Alieva, E V Moguchaya, E U Vasileva, V N Soltsev, E I Baranova, A O Konradi
AIM: to elucidate prevalence of phenotypes of metabolically heathy obesity (MHO) among inhabitants of Saint-Petersburg using various criteria and assess dependence levels of adipokines on obesity phenotype. MATERIAL AND METHODS: Within a framework of epidemiologic study ESSE-RF we formed a random sample of 1600 Saint-Petersburg inhabitants stratified according to gender and age. Examination of participants included anthropometry with measurement of waist circumference CRP and estimation of body mass index (BMI), measurement of arterial pressure, determination of fasting blood glucose, insulin (with calculation of index of insulin resistance -IIR), lipid spectrum, C-reactive protein (CRP), adiponectin, leptin...
August 2016: Kardiologiia
https://www.readbyqxmd.com/read/28238496/prevalence-of-polycystic-ovary-syndrome-in-chinese-obese-women-of-reproductive-age-with-or-without-metabolic-syndrome
#14
Peiwen Liang, Liuqing Xi, Juan Shi, Wanyu Li, Shaoqian Zhao, Yuying Deng, Rui Wang, Yingkai Sun, Bin Gu, Lihui Yuan, Yifei Zhang, Weiqiong Gu, Weiqing Wang, Jie Hong
OBJECTIVE: To compare the prevalence of polycystic ovary syndrome (PCOS) and related clinical characteristics between metabolically unhealthy obese (MUO) and metabolically healthy obese (MHO) women of reproductive age. DESIGN: Cross-sectional clinical study. SETTING: Tertiary hospital. PATIENT(S): We studied 299 MUO and 122 MHO Chinese women matched on body mass index. Metabolically healthy obese was defined as obesity with no more than one metabolic abnormality...
April 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28236433/regulators-of-mitochondrial-quality-control-differ-in-subcutaneous-fat-of-metabolically-healthy-and-unhealthy-obese-monkeys
#15
Kylie Kavanagh, Ashley T Davis, Diane E Peters, Andre C LeGrand, Manish S Bharadwaj, Anthony J A Molina
OBJECTIVE: Obesity exists with and without accompanying cardiometabolic disease, termed metabolically unhealthy obesity (MUO) and healthy obesity (MHO), respectively. Underlying differences in the ability of subcutaneous (SQ) fat to respond to nutrient excess are emerging as a key pathway. This study aimed to document the first spontaneous animal model of MHO and MUO and differences in SQ adipose tissue. METHODS: Vervet monkeys (Chlorocebus aethiops; N = 171) were screened for metabolic syndrome...
April 2017: Obesity
https://www.readbyqxmd.com/read/28213199/cardiovascular-risk-in-different-obesity-phenotypes-over-a-decade-follow-up-tehran-lipid-and-glucose-study
#16
Bita Mirzaei, Hengameh Abdi, Sara Serahati, Maryam Barzin, Mahtab Niroomand, Fereidoun Azizi, Farhad Hosseinpanah
BACKGROUND AND AIMS: Considering the inconsistent data available on cardiovascular (CV) risk of different obesity phenotypes, the aim of this study was to investigate the development of cardiovascular disease (CVD) in different obesity phenotypes over a median follow-up of 12 years. METHODS: In this large population-based cohort, 7842 participants (44.8% men), aged ≥ 30 years, were enrolled. Participants were divided into six phenotypes based on body mass index and metabolic status...
March 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28182633/characterizing-the-coding-region-determinant-binding-protein-crd-bp-microphthalmia-associated-transcription-factor-mitf-mrna-interaction
#17
Gerrit van Rensburg, Sebastian Mackedenski, Chow H Lee
Coding region determinant-binding protein (CRD-BP) binds to the 3'-UTR of microphthalmia-associated transcription factor (MITF) mRNA to prevent its targeted degradation by miR-340. Here, we aim to further understand the molecular interaction between CRD-BP and MITF RNA. Using point mutation in the GXXG motif of each KH domains, we showed that all four KH domains of CRD-BP are important for their physical association with MITF RNA. We mapped the CRD-BP-binding site in the 3'-UTR of MITF RNA from nts 1330-1740 and showed that the 49-nt fragment 1621-1669 is the minimal size MITF RNA for binding...
2017: PloS One
https://www.readbyqxmd.com/read/28177726/vitamin-d-status-is-not-related-to-insulin-resistance-in-different-phenotypes-of-moderate-obesity
#18
Manal Al Masri, Ahmed Jerome Romain, Catherine Boegner, Laurent Maimoun, Denis Mariano-Goulart, Vincent Attalin, Elodie Leprieur, Marion Picandet, Antoine Avignon, Ariane Sultan
Low plasma 25-hydroxy-vitamin D (25OHD) and high levels of parathyroid hormone (PTH) are associated with obesity and could play a role in the occurrence of complications such as insulin resistance. The objective of the study was to evaluate whether the relationship between 25OHD status and phosphocalcic parameters differs between metabolically healthy obese (MHO) and insulin-resistant obese (IRO). This cross-sectional study included 158 consecutive adults (121 females) with obesity (body mass index (BMI) 35...
January 3, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28160438/metabolically-healthy-obesity-and-incident-chronic-kidney-disease-the-role-of-systemic-inflammation-in-a-prospective-study
#19
Lin Lin, Kui Peng, Rui Du, Xiaolin Huang, Jieli Lu, Yu Xu, Min Xu, Yuhong Chen, Yufang Bi, Weiqing Wang
OBJECTIVE: To investigate the association between the metabolically healthy obesity (MHO) phenotype and incident chronic kidney disease (CKD) in a Chinese population and whether systemic inflammation affects this association. METHODS: A cohort study was performed with 2,491 Chinese adults. Body mass index ≥ 25.0 kg/m(2) was defined as obesity. CKD was defined as estimated glomerular filtration rate < 60 mL/min per 1.73 m(2) or urinary albumin-to-creatinine ratio ≥ 30 mg/g...
March 2017: Obesity
https://www.readbyqxmd.com/read/28143590/the-most-important-questions-in-cancer-research-and-clinical-oncology-question-2-5-obesity-related-cancers-more-questions-than-answers
#20
EDITORIAL
Ajit Venniyoor
Obesity is recognized as the second highest risk factor for cancer. The pathogenic mechanisms underlying tobacco-related cancers are well characterized and effective programs have led to a decline in smoking and related cancers, but there is a global epidemic of obesity without a clear understanding of how obesity causes cancer. Obesity is heterogeneous, and approximately 25% of obese individuals remain healthy (metabolically healthy obese, MHO), so which fat deposition (subcutaneous versus visceral, adipose versus ectopic) is "malignant"? What is the mechanism of carcinogenesis? Is it by metabolic dysregulation or chronic inflammation? Through which chemokines/genes/signaling pathways does adipose tissue influence carcinogenesis? Can selective inhibition of these pathways uncouple obesity from cancers? Do all obesity related cancers (ORCs) share a molecular signature? Are there common (over-lapping) genetic loci that make individuals susceptible to obesity, metabolic syndrome, and cancers? Can we identify precursor lesions of ORCs and will early intervention of high risk individuals alter the natural history? It appears unlikely that the obesity epidemic will be controlled anytime soon; answers to these questions will help to reduce the adverse effect of obesity on human condition...
January 31, 2017: Chinese Journal of Cancer
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