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Farshad Farzadfar, Abolghasem Djazayery, Lu Qi, Minoo Bagheri, Mir Saeed Yekaninejad, Maryam Chamari, Maryam Naderi, Zarin Ebrahimi, Berthold Koletzko, Olaf Uhl
BACKGROUND: Uncertainty remains about the effect of vitamin D therapy on biomarkers of health status in obesity. The molecular basis underlying this controversy is largely unknown. OBJECTIVE: To address the existing gap, our study sought to compare changes in metabolomic profiles of obesity phenotypes (metabolically healthy obese (MHO) and metabolically unhealthy obese (MUHO)) patients with sub-optimal levels of vitamin D following vitamin D supplementation. METHODS: We conducted two randomized double-blind clinical trials on participants with either of the two obesity phenotypes from Tehran province...
June 11, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Myong Ki Baeg, Sun-Hye Ko, Seung Yeon Ko, Hee Sun Jung, Myung-Gyu Choi
BACKGROUND: Obesity is a known risk factor for erosive esophagitis (EE) and metabolic unhealthiness has been implicated in EE pathogenesis. However, obesity and metabolic unhealthiness are not synonymous and the associations between obesity, metabolic health, and EE are unclear. Therefore, our aim was to investigate the relationship between EE, obesity, and metabolic health. METHODS: We performed a retrospective cross-sectional study of subjects undergoing health screening at a university hospital...
June 8, 2018: BMC Gastroenterology
Enrique Almanza-Aguilera, Carl Brunius, M Rosa Bernal-Lopez, Mar Garcia-Aloy, Francisco Madrid-Gambin, Francisco J Tinahones, Ricardo Gómez-Huelgas, Rikard Landberg, Cristina Andres-Lacueva
Little is known regarding metabolic benefits of weight loss (WL) on the metabolically healthy obese (MHO) patients. We aimed to examine the impact of a lifestyle weight loss (LWL) treatment on the plasma metabolomic profile in MHO individuals. Plasma samples from 57 MHO women allocated to an intensive LWL treatment group (TG, hypocaloric Mediterranean diet and regular physical activity, n = 30) or to a control group (CG, general recommendations of a healthy diet and physical activity, n = 27) were analysed using an untargeted 1H-NMR metabolomics approach at baseline, after 3 months (intervention) and 12 months (follow-up)...
June 7, 2018: Journal of Proteome Research
Merav Margolis-Gil, Michal Yackobovitz-Gavan, Moshe Phillip, Shlomit Shalitin
BACKGROUND/AIMS: Childhood obesity and associated metabolic comorbidities is a major global health concern. Metabolically healthy obesity (MHO) may represent a subgroup of individuals in which excessive body fat accumulation does not lead to adverse metabolic effects. We aimed to determine the prevalence of MHO among obese Israeli children and adolescents and to find predictors for metabolically unhealthy obesity (MUO). METHODS: In a retrospective study, demographic, anthropometric, lifestyle, and cardiometabolic data were retrieved from medical records of patients with a BMI >95th percentile aged 6-17...
May 26, 2018: Pediatric Diabetes
Rozenn Nedelec, Jari Jokelainen, Jouko Miettunen, Aimo Ruokonen, Karl-Heinz Herzig, Minna Männikkö, Marjo-Riitta Järvelin, Sylvain Sebert
BACKGROUND: A body of literature suggests a metabolically healthy phenotype in individuals with obesity. Despite important clinical implications, the early origins of metabolically healthy obesity (MHO) have received little attention. OBJECTIVE: To assess the prevalence of MHO among the Northern Finland Birth Cohort 1966 (NFBC1966) at 31 years of age, examine its determinants in early life taking into account the sex specificity. METHODS: We studied 3205 term-born cohort participants with data available for cardio-metabolic health outcomes at 31 years, and longitudinal height and weight data...
May 24, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Inyoung Choi, Heesun Moon, So Young Kang, Hyeonyoung Ko, Jinyoung Shin, Jungkwon Lee
BACKGROUND: The present study aimed at identifying the difference in the risk of microalbuminuria among individuals with various obesity phenotypes in terms of metabolic health and obesity. METHODS: This cross-sectional study included 15,268 individuals and used data from the National Health and Nutrition Survey conducted from 2011 to 2014. Obesity was defined as body mass index ≥25 kg/m². Metabolically unhealthy was defined as meeting two or more of the following criteria: systolic and diastolic blood pressure ≥130/85 mm Hg or current use of hypertensive drugs; triglyceride level ≥150 mg/dL; high-density lipoprotein level <40/50 mg/dL (in both men and women); and fasting blood glucose level ≥100 mg/dL or current use of oral antidiabetic medications...
May 2018: Korean Journal of Family Medicine
Haoran Liu, Fanliang Meng, Huiying Miao, Shanshan Chen, Tingting Yin, Songshen Hu, Zhiyong Shao, Yuanyuan Liu, Liuxiao Gao, Changqing Zhu, Bo Zhang, Qiaomei Wang
Effects of postharvest methyl jasmonate (MeJA) treatment on the contents of ascorbic acid and carotenoids, as well as the compositions and contents of volatile organic compounds (VOCs) in cherry tomato fruits were investigated during 11 days of storage at room temperature (25 °C). The results showed that MeJA treatment significantly increased the contents of ascorbic acid and carotenoids, especially lycopene in postharvest cherry tomato fruits. Moreover, MeJA treatment improved the contents of carotenoids derived VOCs such as 6-methyl-5-hepten-2-one (MHO), while had no effect on firmness, sugars and titratable acidity...
October 15, 2018: Food Chemistry
Osama Moussa, Chanpreet Arhi, Paul Ziprin, Ara Darzi, Omar Khan, Sanjay Purkayastha
INTRODUCTION: The metabolically healthy obese (MHO) phenotype may express typical characteristics on long-term follow-up. Little is known about the initiation of this phenotypes and its future stability. AIM: The Clinical Practice Research Datalink (CPRD) is a large-scale primary care database. The aim of this study was to assess the stability of, and evaluate the factors associated with a transition into an unhealthy outcome in, a MHO population in the UK. METHODS: The CPRD was interrogated for a diagnosis of 'obesity' and cross-referenced with a body mass index (BMI) ≥35 kg/m2 ; participants were further classified as MH using a clinical diagnostic code or a relative therapeutic code...
May 17, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Ayo P Doumatey, William J He, Amadou Gaye, Lin Lei, Jie Zhou, Gary H Gibbons, Adebowale Adeyemo, Charles N Rotimi
Obese individuals without expected metabolic co-morbidities are referred to as metabolically healthy obese (MHO). The molecular mechanisms underlying this phenotype remain elusive. MicroRNAs may be involved in the MHO phenotype. To test this hypothesis, we screened 179 serum miRNAs in 20 African-American women (10 MHOs and 10 metabolically abnormal obese individuals -MAO). We identified 8 differentially expressed miRNAs (DEMs) with validation in an independent sample of 64 MHO and 34 MAO. Of the eight DEMs in the screening phase (p ≤ 0...
May 16, 2018: Scientific Reports
Marika de Winter, Brittany V Rioux, Jonathan G Boudreau, Danielle R Bouchard, Martin Sénéchal
Background: Some individuals living with obesity are free from typical cardiometabolic risk factors and are termed metabolically healthy obese (MHO). The patterns of physical activity and sedentary behaviors among MHO are currently unknown. Methods: This study includes 414 youth (12-18 years old), 802 adults (19-44 years old), and 1230 older adults (45-85 years old) living with obesity from the 2003-2004 or 2005-2006 NHANES cycles. Time spent in bouts of 1, 5, 10, 30, and 60 minutes for moderate-to-vigorous physical activity (MVPA) and sedentary time was measured objectively using accelerometers...
2018: Journal of Diabetes Research
Yong-Moon Mark Park, Moon Kyung Choi, Seong-Su Lee, Nitin Shivappa, Kyungdo Han, Susan E Steck, James R Hébert, Anwar T Merchant, Dale P Sandler
BACKGROUND & AIMS: This study was designed to investigate the association between the dietary inflammatory index (DII® ) scores, metabolic phenotypes, and risk of mortality risk in overweight/obese individuals from a representative sample of the U.S. POPULATION: <AbstractText Label="METHODS" NlmCategory="METHODS">Data from 3733 overweight/obese adults (BMI ≥ 25 kg/m2 ) aged 20-90 years from the National Health and Nutrition Examination Survey III, 1988-1994 were analyzed; these participants were followed for mortality through December 31, 2011...
April 16, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Morgana Mongraw-Chaffin, Meredith C Foster, Cheryl A M Anderson, Gregory L Burke, Nowreen Haq, Rita R Kalyani, Pamela Ouyang, Christopher T Sibley, Russell Tracy, Mark Woodward, Dhananjay Vaidya
BACKGROUND: Debate over the cardiometabolic risk associated with metabolically healthy obesity (MHO) continues. Many studies have investigated this relationship by examining MHO at baseline with longitudinal follow-up, with inconsistent results. OBJECTIVES: The authors hypothesized that MHO at baseline is transient and that transition to metabolic syndrome (MetS) and duration of MetS explains heterogeneity in incident cardiovascular disease (CVD) and all-cause mortality...
May 1, 2018: Journal of the American College of Cardiology
Takuro Okamura, Yoshitaka Hashimoto, Masahide Hamaguchi, Akihiro Ohbora, Takao Kojima, Michiaki Fukui
Metabolically healthy obese (MHO) individual is known to be defended from the metabolic complications of obesity. Leukoaraiosis, which is commonly detected on brain magnetic resonance imaging (MRI), is now recognized as a risk of stroke, dementia and death. However, the association between MHO and the prevalence of leukoaraiosis is unclear. In this cross-sectional study of 796 participants who received a medical examination program, we investigated the association between MHO and the prevalence of leukoaraiosis...
April 10, 2018: Endocrine Journal
Atieh Amouzegar, Elham Kazemian, Hengameh Abdi, Mohammad Ali Mansournia, Mahmood Bakhtiyari, Mahbobeh Sadat Hosseini, Fereidoun Azizi
BACKGROUND: Considering inconsistent and conflicting data on associations of thyroid function, within the reference range, with anthropometric measures and metabolic syndrome, this study aimed to investigate the relationship between thyroid function and different obesity phenotypes over nine years of follow-up. METHODS: This study was conducted on 1938 individuals from an ongoing population-based cohort study, the Tehran Thyroid Study. Participants were categorized into four obesity phenotypes based on body mass index and metabolic status...
April 2018: Thyroid: Official Journal of the American Thyroid Association
Hyun-Jung Lee, Eue-Keun Choi, Seung-Hwan Lee, Yong-Jin Kim, Kyung-Do Han, Seil Oh
BACKGROUND: Whether metabolically healthy obese (MHO) individuals are at increased risk of ischemic stroke is not well known. We investigated the association of the MHO phenotype with ischemic stroke. METHODS: A total of 354,083 adults (age 45.8 ± 14.2 years) from the Korean National Health Insurance Service-National Sample Cohort enrolled in 2004-2008 were followed-up for incident ischemic stroke until 2013. Subjects meeting none of the metabolic syndrome criteria were classified as 'metabolically healthy'...
2018: PloS One
E M Robson, S Costa, M Hamer, W Johnson
BACKGROUND: There is heterogeneity among obese individuals, as some appear to have healthier metabolic profiles and decreased health risks. These individuals are defined as metabolically healthy obese (MHO), whilst those with unhealthy metabolic profiles are defined as metabolically unhealthy obese (MUO). To date, most research on MHO has been cross-sectional or focused on disease prognosis. However, longitudinal studies are required to provide greater insight into the life course factors that contribute to the development of MHO...
March 27, 2018: Systematic Reviews
Enrique Rodriguez-Garcia, Josefina Ruiz-Nava, Sonia Santamaria-Fernandez, Jose Carlos Fernandez-Garcia, Antonio Vargas-Candela, Raquel Yahyaoui, Francisco J Tinahones, M Rosa Bernal-Lopez, Ricardo Gomez-Huelgas
OBJECTIVE: There is a lack of consensus when it comes to establishing the biochemical parameters that define metabolically healthy obese (MHO) subjects. Indeed, most studies do not include subjects' lipid profiles. Our objective was to characterize lipoprotein size, particle and subclass concentration using 1 H NMR in MHO women after two years of weight loss with a hypocaloric Mediterranean diet and physical exercise. METHODS: 115 non-diabetic women (aged 35-55 years) with a body mass index (BMI) of 30-40 kg/m2 and ≤1 of the following criteria: blood pressure ≥135/85 mmHg, fasting plasma glucose ≥100 mg/dL, HDL cholesterol ≤50 mg/dL and triglycerides ≥150 mg/dL were included...
July 2018: Chemistry and Physics of Lipids
Bahareh Sedaghati-Khayat, Maryam Barzin, Mahdi Akbarzadeh, Kamran Guity, Mohammad-Sadegh Fallah, Hoda Pourhassan, Fereidoun Azizi, Maryam S Daneshpour
BACKGROUND: Obesity is currently an international epidemic and metabolic derangements pose these individuals at greater risk for future morbidity and mortality. Genetics and environmental factors have undeniable effects and among genetic risk factors, FTO/CETP genes are important. The current study examines the interaction between obesity phenotypes and FTO/CETP SNPs and their effects on lipid profile changes. MATERIALS AND METHODS: We selected 954 adult subjects from TCGS (47...
March 10, 2018: Eating and Weight Disorders: EWD
Banaz Al-Khalidi, Samantha M Kimball, Jennifer L Kuk, Chris I Ardern
BACKGROUND & AIMS: Previous studies assessing the prognosis of metabolically healthy obesity (MHO) have been limited by a lack of a harmonized definition of MHO phenotype. Furthermore, obesity is a risk factor for vitamin D deficiency and low vitamin D status has been associated with a higher risk of mortality; however, few studies have evaluated the joint association between vitamin D, metabolic health phenotype, and mortality risk. Using a harmonized definition, we investigated whether MHO is associated with subsequent all-cause and cardiometabolic mortality, and whether serum 25-hydroxyvitamin D [25(OH)D] modifies these associations...
March 2, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Minoo Bagheri, Farshad Farzadfar, Lu Qi, Mir Saeed Yekaninejad, Maryam Chamari, Oana A Zeleznik, Zahra Kalantar, Zarin Ebrahimi, Ali Sheidaie, Berthold Koletzko, Olaf Uhl, Abolghasem Djazayery
A particular subgroup of obese adults, considered as metabolically healthy obese (MHO), has a reduced risk of metabolic complications. However, the molecular basis contributing to this healthy phenotype remains unclear. The objective of this work was to identify obesity-related metabolite patterns differed between MHO and metabolically unhealthy obese (MUHO) groups and examine whether these patterns are associated with the development of cardiometabolic disorders in a sample of Iranian adult population aged 18-50 years...
April 6, 2018: Journal of Proteome Research
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