keyword
MENU ▼
Read by QxMD icon Read
search

MHO

keyword
https://www.readbyqxmd.com/read/28213199/cardiovascular-risk-in-different-obesity-phenotypes-over-a-decade-follow-up-tehran-lipid-and-glucose-study
#1
Bita Mirzaei, Hengameh Abdi, Sara Serahati, Maryam Barzin, Mahtab Niroomand, Fereidoun Azizi, Farhad Hosseinpanah
BACKGROUND AND AIMS: Considering the inconsistent data available on cardiovascular (CV) risk of different obesity phenotypes, the aim of this study was to investigate the development of cardiovascular disease (CVD) in different obesity phenotypes over a median follow-up of 12 years. METHODS: In this large population-based cohort, 7842 participants (44.8% men), aged ≥ 30 years, were enrolled. Participants were divided into six phenotypes based on body mass index and metabolic status...
February 3, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28182633/characterizing-the-coding-region-determinant-binding-protein-crd-bp-microphthalmia-associated-transcription-factor-mitf-mrna-interaction
#2
Gerrit van Rensburg, Sebastian Mackedenski, Chow H Lee
Coding region determinant-binding protein (CRD-BP) binds to the 3'-UTR of microphthalmia-associated transcription factor (MITF) mRNA to prevent its targeted degradation by miR-340. Here, we aim to further understand the molecular interaction between CRD-BP and MITF RNA. Using point mutation in the GXXG motif of each KH domains, we showed that all four KH domains of CRD-BP are important for their physical association with MITF RNA. We mapped the CRD-BP-binding site in the 3'-UTR of MITF RNA from nts 1330-1740 and showed that the 49-nt fragment 1621-1669 is the minimal size MITF RNA for binding...
2017: PloS One
https://www.readbyqxmd.com/read/28177726/vitamin-d-status-is-not-related-to-insulin-resistance-in-different-phenotypes-of-moderate-obesity
#3
Manal Al Masri, Ahmed Jerome Romain, Catherine Boegner, Laurent Maimoun, Denis Mariano-Goulart, Vincent Attalin, Elodie Leprieur, Marion Picandet, Antoine Avignon, Ariane Sultan
BACKGROUND/OBJECTIVES: Low plasma 25-hydroxy-vitamin D (25OHD) and high levels of parathyroid hormone (PTH) are associated with obesity and could play a role in the occurrence of its complications such as insulin resistance. The objective of the study was to evaluate whether the relationship between 25OHD status and phosphocalcic parameters differ between metabolically healthy obese (MHO) and insulin-resistant obese (IRO). SUBJECTS/METHODS: Cross-sectional study including 158 consecutive adults (121 females) with obesity (BMI 35...
January 3, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28160438/metabolically-healthy-obesity-and-incident-chronic-kidney-disease-the-role-of-systemic-inflammation-in-a-prospective-study
#4
Lin Lin, Kui Peng, Rui Du, Xiaolin Huang, Jieli Lu, Yu Xu, Min Xu, Yuhong Chen, Yufang Bi, Weiqing Wang
OBJECTIVE: To investigate the association between the metabolically healthy obesity (MHO) phenotype and incident chronic kidney disease (CKD) in a Chinese population and whether systemic inflammation affects this association. METHODS: A cohort study was performed with 2,491 Chinese adults. Body mass index ≥ 25.0 kg/m(2) was defined as obesity. CKD was defined as estimated glomerular filtration rate < 60 mL/min per 1.73 m(2) or urinary albumin-to-creatinine ratio ≥ 30 mg/g...
February 3, 2017: Obesity
https://www.readbyqxmd.com/read/28143590/the-most-important-questions-in-cancer-research-and-clinical-oncology-question-2-5-obesity-related-cancers-more-questions-than-answers
#5
EDITORIAL
Ajit Venniyoor
Obesity is recognized as the second highest risk factor for cancer. The pathogenic mechanisms underlying tobacco-related cancers are well characterized and effective programs have led to a decline in smoking and related cancers, but there is a global epidemic of obesity without a clear understanding of how obesity causes cancer. Obesity is heterogeneous, and approximately 25% of obese individuals remain healthy (metabolically healthy obese, MHO), so which fat deposition (subcutaneous versus visceral, adipose versus ectopic) is "malignant"? What is the mechanism of carcinogenesis? Is it by metabolic dysregulation or chronic inflammation? Through which chemokines/genes/signaling pathways does adipose tissue influence carcinogenesis? Can selective inhibition of these pathways uncouple obesity from cancers? Do all obesity related cancers (ORCs) share a molecular signature? Are there common (over-lapping) genetic loci that make individuals susceptible to obesity, metabolic syndrome, and cancers? Can we identify precursor lesions of ORCs and will early intervention of high risk individuals alter the natural history? It appears unlikely that the obesity epidemic will be controlled anytime soon; answers to these questions will help to reduce the adverse effect of obesity on human condition...
January 31, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/27992361/risk-factors-that-affect-metabolic-health-status-in-obese-children
#6
Selin Elmaogullari, Fatma Demirel, Nihal Hatipoglu
BACKGROUND: While some obese children are metabolically healthy (MHO), some have additional health problems, such as hypertension, dyslipidemia, insulin resistance, and hepatosteatosis, which increase mortality and morbidity related to cardiovascular diseases (CVD) during adulthood. These children are metabolically unhealthy obese (MUO) children. In this study we assessed the factors that affect metabolic health in obesity and the clinical and laboratory findings that distinguish between MHO and MUO children...
January 1, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/27934268/volatile-organic-compound-emissions-from-humans-indoors
#7
Xiaochen Tang, Pawel K Misztal, William W Nazaroff, Allen H Goldstein
Research on the sources of indoor airborne chemicals has traditionally focused on outdoor air, building materials, furnishings, and activities such as smoking, cooking, and cleaning. Relatively little research has examined the direct role of occupant emissions, even though this source clearly contributes to indoor volatile organic compounds (VOCs) and influences indoor chemistry. In this work, we quantify occupant-related gaseous VOC emissions in a university classroom using a proton-transfer-reaction time-of-flight mass spectrometer...
December 6, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27923446/obesity-is-more-closely-related-with-hepatic-steatosis-and-fibrosis-measured-by-transient-elastography-than-metabolic-health-status
#8
Ji Hye Huh, Kwang Joon Kim, Seung Up Kim, Seung Hwan Han, Kwang-Hyub Han, Bong-Soo Cha, Choon Hee Chung, Byung-Wan Lee
OBJECTIVE: The pathogenesis of non-alcoholic fatty liver disease (NAFLD) involves multiple concomitant events induced by obesity and metabolic health condition. This study aimed to assess the risk of NAFLD according to metabolic health and obesity status using transient elastography (TE). MATERIALS AND METHODS: A total of 2198 asymptomatic adults without chronic liver disease and who underwent a medical health check-up were recruited. Subjects were categorized into four groups according to metabolic health and obesity statuses: metabolically healthy non-obese (MHNO); metabolically unhealthy non-obese (MUNO); metabolically healthy obese (MHO); and metabolically unhealthy obese (MUO)...
January 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27907186/inter-tissue-gene-co-expression-networks-between-metabolically-healthy-and-unhealthy-obese-individuals
#9
Lisette J A Kogelman, Jingyuan Fu, Lude Franke, Jan Willem Greve, Marten Hofker, Sander S Rensen, Haja N Kadarmideen
BACKGROUND: Obesity is associated with severe co-morbidities such as type 2 diabetes and nonalcoholic steatohepatitis. However, studies have shown that 10-25 percent of the severely obese individuals are metabolically healthy. To date, the identification of genetic factors underlying the metabolically healthy obese (MHO) state is limited. Systems genetics approaches have led to the identification of genes and pathways in complex diseases. Here, we have used such approaches across tissues to detect genes and pathways involved in obesity-induced disease development...
2016: PloS One
https://www.readbyqxmd.com/read/27905531/a-indicator-of-visceral-adipose-dysfunction-to-evaluate-metabolic-health-in-adult-chinese
#10
Ming-Feng Xia, Ying Chen, Huan-Dong Lin, Hui Ma, Xiao-Ming Li, Qiqige Aleteng, Qian Li, Dan Wang, Yu Hu, Bai-Shen Pan, Xue-Jun Li, Xiao-Ying Li, Xin Gao
Visceral adipose dysfunction is a major cause of metabolic disorders. However, there is lack of a clinical index for prediction of visceral fat dysfunction in Asians. The present study aims to establish a visceral adiposity index for evaluation of metabolic health status in Chinese, the largest Asian ethnic group. 485 subjects were recruited from Lianqian Community, Xiamen and received abdominal computed tomography(CT) for visceral fat area. A Chinese visceral adiposity index (CVAI) was created using multivariate linear regression analyses, and was further validated in 6495 subjects recruited from Changfeng Community, Shanghai...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27897994/disability-physical-inactivity-and-impaired-health-related-quality-of-life-are-not-different-in-metabolically-healthy-vs-unhealthy-obese-subjects
#11
Lorenzo M Donini, Gianluca Merola, Eleonora Poggiogalle, Carla Lubrano, Lucio Gnessi, Stefania Mariani, Silvia Migliaccio, Andrea Lenzi
BACKGROUND: Obesity represents a major health hazard, affecting morbidity, psychological status, physical functionality, quality of life, and mortality. The aim of the present study was to explore the differences between metabolically healthy (MHO) and metabolically unhealthy (MUO) obese subjects with regard to physical activity, disability, and health-related quality of life (HR-QoL). METHODS: All subjects underwent a multidimensional evaluation, encompassing the assessment of body composition, metabolic biomarkers and inflammation, physical activity level (IPAQ questionnaire), disability (TSD-OC test), and HR-QoL (SF-36 questionnaire)...
November 25, 2016: Nutrients
https://www.readbyqxmd.com/read/27866959/evaluating-the-risk-of-hypertension-according-to-the-metabolic-health-status-stratified-by-degree-of-obesity
#12
Jae-Hong Ryoo, Sung Keun Park, Chang-Mo Oh, Young-Jun Choi, Ju Youn Chung, Woo Taek Ham, Taegi Jung
Despite the accumulated evidence showing the significant association between hypertension and obesity, it remains unclear how metabolic healthy status of obesity have an impact on the development of hypertension. Thus, this study was to investigate the risk of hypertension according to the metabolic healthy status stratified by the degree of obesity. A cohort of 25,442 Korean men without hypertension at baseline was followed-up from 2005 to 2010. They were divided into the following 6 phenotypes according to their baseline metabolic health and obesity status: metabolically healthy normal weight (MH-NW), metabolically healthy overweight (MH-OW), metabolically healthy obese (MHO), metabolically unhealthy normal weight (MU-NW), metabolically unhealthy overweight (MU-OW), and metabolically unhealthy obese (MUO)...
November 2, 2016: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/27853670/features-of-omental-adipose-tissue-in-endometrial-cancer-patients-with-standard-or-metabolically-healthy-obesity-associations-with-tumor-process-characteristics
#13
Lev M Berstein, Aglaya G Iyevleva, Marina S Mukhina, Dmitry A Vasilyev, Tatyana E Poroshina
PURPOSE: Adipose tissue products may contribute to endometrial cancer (EC) initiation and further growth that encourages the analysis of this issue in patients with different obesity phenotypes. METHODS/PATIENTS: Omental fat depot characteristics were studied in EC patients (n = 57) with "standard" (SO) or "metabolically healthy" (MHO) obesity. Collected omental samples were evaluated by immunohistochemistry /IHC/ for brown fat marker UCP1, CYP19 (aromatase) and macrophage infiltration markers (CD68, CD163, crown-like structures/CLS) expression...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27804254/are-all-metabolically-healthy-individuals-with-obesity-at-the-same-risk-of-diabetes-onset
#14
David Navarro-González, Laura Sánchez-Íñigo, Alejandro Fernández-Montero, Juan Pastrana-Delgado, J Alfredo Martínez
OBJECTIVE: To examine the risk of diabetes and the development of an unhealthy status according to metabolic health. To assess the effect of changes in metabolic health among participants with metabolically healthy obesity (MHO) on the risk of diabetes. METHODS: A total of 4,340 subjects were included. Unhealthy metabolic status was defined as having three or more risk factors of the Adult Treatment Panel-III criteria. A Cox proportional-hazard analysis was conducted to estimate the hazard ratio (HR) of developing diabetes across the change in the metabolic status of subjects with MHO...
November 2, 2016: Obesity
https://www.readbyqxmd.com/read/27776717/metabolically-obese-individuals-of-normal-weight-have-a-high-risk-of-25-hydroxyvitamin-d-deficiency
#15
Xiaoli Wang, Xiangyun Chang, Yurong Zhu, Huan Wang, Kan Sun
BACKGROUND: Vitamin D status is related to obesity-related metabolic disorders. We investigated the risk of 25-hydroxyvitamin D [25(OH)D] deficiency among different metabolic phenotypes. METHODS: This prospective cross-sectional study evaluated 1,292 individuals who were ≥40 years old. Participants were classified as metabolically healthy and normal weight (MHNW), metabolically obese but normal weight (MONW), metabolically healthy but obese (MHO) or metabolically unhealthy and obese (MUO)...
October 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27753996/ed-07-1-contribution-of-cardiopulmonary-fitness-in-obesity-phenotypes-and-incident-hypertension
#16
Sae Young Jae
Obesity is associated with an increased risk of morbidity and mortality from cardiometabolic diseases, but not all obese individuals are at increased risk. This phenotype of obesity is referred to as "metabolically healthy obesity (MHO)." MHO describes a cohort of the obese population with relatively low risk of cardiovascular and metabolic diseases. Although MHO has favorable metabolic profiles such as insulin sensitivity, low inflammatory markers, and low body fat, there remains a substantial unexplained variance...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753840/sy-06-4-the-risk-of-metabolically-healthy-obesity-in-cardiovascular-disease
#17
Ki Chul Sung
BMI is a proxy measure for adiposity in population-based studies and it is well established that increasing body fat is strongly associated with component features of the metabolic syndrome (MetS), such as dyslipidaemia (low high density lipoprotein cholesterol (HDL-C) and high triglyceride concentrations, increased glucose concentrations, high blood pressure, hypertension, and type 2 diabetes. Whether any or all of these components of the MetS account for relationships between body fatness and all cause mortality is uncertain, but we have recently shown in a large Korean cohort that co-existing cardiovascular disease (CVD), diabetes or hypertension explained much of the increased risk of CVD mortality in obese individuals...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27748744/metabolic-phenotypes-of-obesity-frequency-correlates-and-change-over-time-in-a-cohort-of-postmenopausal-women
#18
G C Kabat, W Y-Y Wu, J W Bea, C Chen, L Qi, M L Stefanick, R T Chlebowski, D S Lane, J Wactawski-Wende, S Wassertheil-Smoller, T E Rohan
OBJECTIVE: The possibility that a subset of persons who are obese may be metabolically healthy-referred to as the 'metabolically healthy obese' (MHO) phenotype-has attracted attention recently. However, few studies have followed individuals with MHO or other obesity phenotypes over time to assess change in their metabolic profiles. The aim of the present study was to examine transitions over a 6-year period among different states defined simultaneously by body mass index (BMI) and the presence/absence of the metabolic syndrome (MetS)...
January 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27733246/clinical-implication-of-body-size-phenotype-on-heart-rate-variability
#19
Hye Jin Yoo, Soon Young Hwang, Kyung Mook Choi, Sei Hyun Baik, Eun Mi Lee, Eung Joo Kim, Seung-Woon Rha, Chang Gyu Park, Dong Joo Oh, Hong Seog Seo
We compared heart rate variability (HRV) values according to the following body size phenotypes: metabolically healthy normal weight (MHNW), metabolically unhealthy but normal weight (MUNW), metabolically healthy but obese (MHO), and metabolically unhealthy obese (MUO). We retrospectively analyzed a dataset from 1200 participants who had visited the Cardiovascular Center at Korea University Guro Hospital between March 2009 and February 2014 and underwent Holter monitoring for 24h. HRV was calculated from standard deviation of normal-to-normal R-R intervals (SDNN), standard deviation of the average normal-to-normal intervals (SDANN), and root mean square of successive differences (rMSSD) measurements, and study subjects were classified according to body mass index (BMI) and presence or absence of metabolic syndrome...
November 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27723940/metabolically-healthy-obesity-across-the-life-course-epidemiology-determinants-and-implications
#20
Catherine M Phillips
In recent years, different subphenotypes of obesity have been described, including metabolically healthy obesity (MHO), in which a proportion of obese individuals, despite excess body fat, remain free of metabolic abnormalities and increased cardiometabolic risk. In the absence of a universally accepted set of criteria to classify MHO, the reported prevalence estimates vary widely. Our understanding of the determinants and stability of MHO over time and the associated cardiometabolic and mortality risks is improving, but many questions remain...
October 10, 2016: Annals of the New York Academy of Sciences
keyword
keyword
97072
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"