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https://www.readbyqxmd.com/read/28781161/prevalence-of-metabolically-healthy-obesity-mho-and-its-relation-with-incidence-of-metabolic-syndrome-hypertension-and-type-2-diabetes-amongst-individuals-aged-over-20-years-in-ahvaz-a-5-year-cohort-study-2009-2014
#1
Seyed Mahmoud Latifi, Majid Karandish, Hajieh Shahbazian, Jalaly Mohammad Taha, Bahman Cheraghian, Mitra Moradi
BACKGROUND: Today, obesity epidemic is one of the major health problems of the present century. One of the phenotypes of obesity is metabolically healthy obesity. It seems that these obese individuals suffer less from cardiovascular disease and metabolically unhealthy obesity. This study aimed to investigate the prevalence of metabolically healthy obesity (MHO) and its relationship with incidence of metabolic syndrome, diabetes and hypertension in individuals over 20 years in the city of Ahvaz...
July 27, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28753664/validation-of-a-novel-mho-microarray-for-a-comprehensive-characterisation-of-the-mycoplasma-hominis-action-in-hela-cell-infection
#2
Birgit Henrich, Freya Kretzmer, René Deenen, Karl Köhrer
Mycoplasma hominis is the second smallest facultative pathogen of the human urogenital tract. With less than 600 protein-encoding genes, it represents an ideal model organism for the study of host-pathogen interactions. For a comprehensive characterisation of the M. hominis action in infection a customized Mho microarray, which was based on two genome sequences (PG21 and LBD-4), was designed to analyze the dynamics of the mycoplasma transcriptome during infection and validated for M. hominis strain FBG. RNA preparation was evaluated and adapted to ensure the highest recovery of mycoplasmal mRNAs from in vitro HeLa cell infection assays...
2017: PloS One
https://www.readbyqxmd.com/read/28743872/social-jetlag-and-metabolic-control-in-non-communicable-chronic-diseases-a-study-addressing-different-obesity-statuses
#3
Maria Carliana Mota, Catarina Mendes Silva, Laura Cristina Tibiletti Balieiro, Walid Makin Fahmy, Cibele Aparecida Crispim
Social jetlag - a measure of disruption of the circadian system - has been linked to obesity, but its association with metabolic complications in non-communicable chronic diseases (NCCDs) is unknown in the literature. We examined the associations between social jetlag and obesity status and metabolic parameters among individuals with NCCDs. Patients (n = 792) with NCCDs (obesity, systemic arterial hypertension, type 2 diabetes mellitus or dyslipidaemia) attended clinics of the public health service of the city of Uberlândia, Minas Gerais State, Brazil...
July 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28737317/-determinants-of-enrolment-and-retention-in-mutual-health-organization-in-the-region-of-ziguinchor-senegal
#4
Ibrahima Seck, Anta Tal Dia, Oumar Sagna, Mamadou Makhtar Leye
Introduction: Despite the recognition of the role of Mutual Health Organization (MHO) as a mechanism to ensure the financial sustainability of health systems, recent studies have shown the existence of obstacles to enrolment and retention in these MHOs. The objective of this study was to examine the determinants of enrolment and retention in MHO in Senegal.Methods: Data collection was conducted from 22 June to 30 September 2015 in Ziguinchor, located 450 km from Dakar by stratified two-stage sampling (n = 912 households)...
March 6, 2017: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/28733797/population-genetic-analysis-of-a-21-plex-dip-panel-in-seven-chinese-ethnic-populations
#5
Youjing Jiang, Wang He, Hui Wang, Dan Chen, Xiaogang Bai, Jienan Li, Weibo Liang, Lin Zhang
A 21-plex DIP (deletion and insertion polymorphism) panel has a good performance in analyzing biogeographic ancestry in three main global population groups (European, African, and Asian). This panel was used to investigate 450 unrelated individuals in seven Chinese ethnic groups (Han, Dong, Miao, Zhuang, Uyghur, Tibetan, and Mongolian). Allele frequencies were calculated. Mho (mean value of observed heterozygosity) ranged from 0.3019 to 0.4367, MHe (mean value of expected heterozygosity) ranged from 0.31175 to 0...
July 21, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28705382/impact-of-cardiorespiratory-fitness-and-risk-of-systemic-hypertension-in-nonobese-versus-obese-men-who-are-metabolically-healthy-or-unhealthy
#6
Sae Young Jae, Abraham Samuel Babu, Eun Sun Yoon, Sudhir Kurl, Jari A Laukkanen, Yoon-Ho Choi, Barry A Franklin
Few data are available regarding the influence of body phenotype on systemic hypertension (SH) and whether cardiorespiratory fitness (CRF) attenuates this relation. We tested the hypothesis that obesity phenotypes and CRF would predict incident hypertension, evaluating 3,800 Korean men who participated in 2 health examinations in1998 to 2009. All participants were normotensive at baseline and were divided into 4 groups based on body mass index using the Asia-Pacific descriptors for obesity and metabolic health status and the National Cholesterol Education Program's adult treatment panel III (ATP-III) criteria...
June 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28694619/mental-health-orientation-for-self-help-group-members-a-feasibility-study
#7
Basavaraj Shrinivasa, Navaneetham Janardhana, Bergai Parthsarathy Nirmala
BACKGROUND: Treatment gap for mental health care in low- and middle-income (LAMI) countries is very large, and building workforce using the locally available resources is very much essential in reducing this gap. The current study is a preliminary work toward this direction. MATERIALS AND METHODS: A single group pre- and post-design was considered for assessing the feasibility of Mental Health Orientation (MHO) Program for Self-Help Group members. Assessment of participants' MHO using Orientation Towards Mental Illness (OMI) scale was undertaken at three levels: Baseline assessment before the intervention, after completing 2 days orientation program, and 6 weeks later...
July 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28693964/impact-of-dietary-intake-lifestyle-and-biochemical-factors-on-metabolic-health-in-obese-adolescents
#8
I Aldhoon-Hainerová, V Hainer, H Zamrazilová
BACKGROUND AND AIMS: Obesity devoid of metabolic abnormalities is known as metabolically healthy obesity (MHO). The aim of the study was to examine determinants of MHO during adolescence. METHODS AND RESULTS: From among 710 obese adolescents, 43 girls and 57 boys were classified as metabolically unhealthy (abdominal obesity and ≥2 risk components of metabolic syndrome). MHO (absence of any cardiometabolic risk factor) was found in 211 girls and 131 boys (regardless of waist circumference) and in 33 girls and 27 boys (without abdominal obesity)...
May 15, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28682864/characterization-of-lipid-profile-by-nuclear-magnetic-resonance-spectroscopy-1h-nmr-of-metabolically-healthy-obese-women-after-weight-loss-with-mediterranean-diet-and-physical-exercise
#9
Enrique Rodriguez-Garcia, Josefina Ruiz-Nava, Sonia Santamaria-Fernandez, Jose Carlos Fernandez-Garcia, Antonio Vargas-Candela, Raquel Yahyaoui, Francisco J Tinahones, Maria Rosa Bernal-Lopez, Ricardo Gomez-Huelgas
Obesity is associated with an atherogenic lipid profile. No data exists on lipoprotein particle profiles in metabolically healthy obese (MHO) individuals. Our aim is to characterize lipoprotein size, particle, and subclass concentrations in MHO women after 3 months of weight loss through dietary restriction and physical exercise.A total of 115 nondiabetic women (aged 35-55 years) with a body mass index (BMI) of 30 to 40 kg/m and ≤1 of the following criteria: blood pressure ≤135/85 mm Hg, fasting plasma glucose ≤100 mg/dL, HDL-cholesterol ≤50 mg/dL, and triglycerides ≤150 mg/dL were included...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28644850/visceral-adiposity-index-predicts-the-conversion-of-metabolically-healthy-obesity-to-an-unhealthy-phenotype
#10
Yu Mi Kang, Chang Hee Jung, Yun Kyung Cho, Jung Eun Jang, Jenie Yoonoo Hwang, Eun Hee Kim, Woo Je Lee, Joong-Yeol Park, Hong-Kyu Kim
OBJECTIVE: Some individuals with metabolically healthy obesity (MHO) convert to metabolically unhealthy obesity (MUO) phenotype, and visceral adiposity is one of proposed mechanisms underlying such conversion. Visceral adipose index (VAI) is a novel mathematical model which estimates visceral adiposity based on anthropometric and lipid profiles. We aimed to determine the association of VAI-estimated visceral adiposity with the MHO-to-MUO conversion and the predictive value of VAI in estimating such unfavorable outcomes...
2017: PloS One
https://www.readbyqxmd.com/read/28636624/metabolically-healthy-obesity-is-associated-with-higher-prevalence-of-colorectal-adenoma
#11
Dong Hyun Sinn, Yang Won Min, Hee Jung Son, Poong-Lyul Rhee, Seung Woon Paik, Sung Noh Hong, Geum-Youn Gwak
BACKGROUND: The risk of colorectal adenoma (CRA), an important precursor of colorectal cancer, is largely unknown among obese individuals without obesity-related metabolic abnormalities, a condition described as metabolically-healthy obese (MHO). The aim of this study was to examine the association among metabolic status, the different categories of body mass index (BMI), and CRA in a large cohort of adults. METHODS: We analyzed the association among metabolic status, BMI categories and CRA in asymptomatic adults who underwent a first-time colonoscopy as part of the comprehensive health check-up program at the Health Promotion Center of Samsung Medical Center, from January 2005 to December 2012...
2017: PloS One
https://www.readbyqxmd.com/read/28630460/oxidative-and-endoplasmic-reticulum-stress-is-impaired-in-leukocytes-from-metabolically-unhealthy-vs-healthy-obese-individuals
#12
C Bañuls, S Rovira-Llopis, S Lopez-Domenech, N Diaz-Morales, A Blas-Garcia, S Veses, C Morillas, V M Victor, M Rocha, A Hernandez-Mijares
BACKGROUND: Oxidative stress and inflammation are related to obesity, but the influence of metabolic disturbances on these parameters and their relationship with endoplasmic reticulum (ER) stress is unknown. Therefore, this study was performed to evaluate whether metabolic profile influences ER and oxidative stress in an obese population with/without comorbidities. SUBJECTS AND METHODS: A total of 113 obese patients were enrolled in the study; 29 were metabolically healthy (MHO), 53 were metabolically abnormal (MAO), and 31 had type 2 diabetes (MADO)...
June 20, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28614006/fat-free-mass-metabolically-healthy-obesity-and-type-2-diabetes-in-severely-obese-asian-adults
#13
Pornpoj Pramyothin, Vichol Limpattanachart, Suwitcha Dawilai, Rungnapa Sarasak, Chariya Sukaruttanawong, Kusuma Chaiyasoot, Songsri Keawtanom, Preyanuj Yamwong
OBJECTIVE: To determine whether fat-free mass (FFM) is independently associated with the metabolically healthy obesity (MHO) phenotype, the metabolic syndrome (MS), and type 2 diabetes (T2D) in obese Asian adults. METHODS: Obese patients (BMI ≥25 kg/m(2)) seeking weight management at an academic medical center from 2007-2016 were included. FFM was measured by bioelectrical impedance. RESULTS: Of the 552 patients (67.0% female, median age 40...
June 14, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28602062/metabolically-healthy-obesity-a-friend-or-foe
#14
REVIEW
Chang Hee Jung, Woo Je Lee, Kee-Ho Song
Obesity is associated with a reduced life expectancy, largely because obese individuals are at an increased risk of type 2 diabetes, cardiovascular disease, and several types of cancer. Much interest has recently focused on the concept of "all obesity is not created equally." Obese individuals without the metabolic abnormalities that commonly accompany excess adiposity, a condition known as metabolically healthy obesity (MHO), account for a substantial proportion of the obese adult population. Numerous possible mechanisms underlying MHO have been suggested, including adipose tissue distribution and inflammation...
July 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28601090/physical-health-related-quality-of-life-in-relation-to-metabolic-health-and-obesity-among-men-and-women-in-germany
#15
Julia Truthmann, Gert B M Mensink, Anja Bosy-Westphal, Ulfert Hapke, Christa Scheidt-Nave, Anja Schienkiewitz
BACKGROUND: This study examined sex-specific differences in physical health-related quality of life (HRQoL) across subgroups of metabolic health and obesity. We specifically asked whether (1) obesity is related to lower HRQoL independent of metabolic health status and potential confounders, and (2) whether associations are similar in men and women. METHODS: We used cross-sectional data from the German Health Interview and Examination Survey 2008-11. Physical HRQoL was measured using the Short Form-36 version 2 physical component summary (PCS) score...
June 10, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28575097/influence-of-the-definition-of-metabolically-healthy-obesity-on-the-progression-of-coronary-artery-calcification
#16
Ji Won Yoon, Chan-Hyeon Jung, Min-Kyung Kim, Hyo Eun Park, Kyong Soo Park, Hak Chul Jang, Min Kyong Moon, Su-Yeon Choi, Bo Kyung Koo
OBJECTIVES: Debates whether metabolically healthy obesity (MHO) increases the cardiovascular risk might be due to the metabolic instability of MHO or the absence of a perfect definition of MHO. Therefore, we aimed to investigate the influence of the MHO phenotype on the coronary artery calcium score (CACS) progression according to definition of MHO. METHODS: We analyzed a retrospective cohort with a CACS of 0 at baseline and available serial CACS measurements taken ≥ 12 months apart (n = 1,218)...
2017: PloS One
https://www.readbyqxmd.com/read/28570654/haplotypes-on-pig-chromosome-3-distinguish-metabolically-healthy-from-unhealthy-obese-individuals
#17
Simona D Frederiksen, Peter Karlskov-Mortensen, Sameer D Pant, Maryse Guerin, Philippe Lesnik, Claus B Jørgensen, Susanna Cirera, Camilla S Bruun, Thomas Mark, Merete Fredholm
We have established a pig resource population specifically designed to elucidate the genetics involved in development of obesity and obesity related co-morbidities by crossing the obesity prone Göttingen Minipig breed with two lean production pig breeds. In this study we have performed genome wide association (GWA) to identify loci with effect on blood lipid levels. The most significantly associated single nucleotide polymorphisms (SNPs) were used for linkage disequilibrium (LD) and haplotype analyses. Three separate haploblocks which influence the ratio between high density lipoprotein cholesterol and total cholesterol (HDL-C/CT), triglycerides (TG) and low density lipoprotein cholesterol (LDL-C) levels respectively were identified on Sus Scrofa chromosome 3 (SSC3)...
2017: PloS One
https://www.readbyqxmd.com/read/28564650/the-metabolic-phenotype-in-obesity-fat-mass-body-fat-distribution-and-adipose-tissue-function
#18
Gijs H Goossens
The current obesity epidemic poses a major public health issue since obesity predisposes towards several chronic diseases. BMI and total adiposity are positively correlated with cardiometabolic disease risk at the population level. However, body fat distribution and an impaired adipose tissue function, rather than total fat mass, better predict insulin resistance and related complications at the individual level. Adipose tissue dysfunction is determined by an impaired adipose tissue expandability, adipocyte hypertrophy, altered lipid metabolism, and local inflammation...
2017: Obesity Facts
https://www.readbyqxmd.com/read/28559291/interaction-of-mycoplasma-hominis-pg21-with-human-dendritic-cells-interleukin-23-inducing-mycoplasmal-lipoproteins-and-inflammasome-activation-of-the-cell
#19
J Goret, L Béven, B Faustin, C Contin-Bordes, C Le Roy, S Claverol, H Renaudin, C Bébéar, S Pereyre
Mycoplasma hominis lacks a cell wall, and lipoproteins anchored to the extracellular side of the plasma membrane are in direct contact with the host components. A Triton X-114 extract of M. hominis enriched with lipoproteins was shown to stimulate the production of interleukin-23 (IL-23) by human dendritic cells (hDCs). The inflammasome activation of the host cell has never been reported upon M. hominis infection. We studied here the interaction between M. hominis PG21 and hDCs by analyzing both the inflammation-inducing mycoplasmal lipoproteins and the inflammasome activation of the host cell...
August 1, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28554164/association-between-obesity-phenotypes-and-incident-hypertension-among-chinese-adults-a%C3%A2-prospective-cohort-study
#20
Z K Cao, Y Huang, H J Yu, S Yuan, B W Tang, Q X Li, X T Li, X H Yang, Q Q He
OBJECTIVES: To explore the association between obesity phenotype and the risk of hypertension among Chinese adults. STUDY DESIGN: A prospective cohort study. METHODS: Two waves of data were collected in 2009 and 2011 by the China Health Nutrition Survey. According to International Diabetes Federation and Chinese obesity criteria, participants were divided into four groups: metabolically healthy non-overweight/obesity (MHNO), metabolically healthy overweight/obesity (MHO), metabolically abnormal non-overweight/obesity (MANO), and metabolically abnormal overweight/obesity (MAO)...
May 26, 2017: Public Health
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