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https://www.readbyqxmd.com/read/27413137/genetic-and-environmental-effects-on-body-mass-index-from-infancy-to-the-onset-of-adulthood-an-individual-based-pooled-analysis-of-45-twin-cohorts-participating-in-the-collaborative-project-of-development-of-anthropometrical-measures-in-twins-codatwins-study
#1
Karri Silventoinen, Aline Jelenkovic, Reijo Sund, Yoon-Mi Hur, Yoshie Yokoyama, Chika Honda, Jacob vB Hjelmborg, Sören Möller, Syuichi Ooki, Sari Aaltonen, Fuling Ji, Feng Ning, Zengchang Pang, Esther Rebato, Andreas Busjahn, Christian Kandler, Kimberly J Saudino, Kerry L Jang, Wendy Cozen, Amie E Hwang, Thomas M Mack, Wenjing Gao, Canqing Yu, Liming Li, Robin P Corley, Brooke M Huibregtse, Kaare Christensen, Axel Skytthe, Kirsten O Kyvik, Catherine A Derom, Robert F Vlietinck, Ruth Jf Loos, Kauko Heikkilä, Jane Wardle, Clare H Llewellyn, Abigail Fisher, Tom A McAdams, Thalia C Eley, Alice M Gregory, Mingguang He, Xiaohu Ding, Morten Bjerregaard-Andersen, Henning Beck-Nielsen, Morten Sodemann, Adam D Tarnoki, David L Tarnoki, Maria A Stazi, Corrado Fagnani, Cristina D'Ippolito, Ariel Knafo-Noam, David Mankuta, Lior Abramson, S Alexandra Burt, Kelly L Klump, Judy L Silberg, Lindon J Eaves, Hermine H Maes, Robert F Krueger, Matt McGue, Shandell Pahlen, Margaret Gatz, David A Butler, Meike Bartels, Toos Cem van Beijsterveldt, Jeffrey M Craig, Richard Saffery, Duarte L Freitas, José Antonio Maia, Lise Dubois, Michel Boivin, Mara Brendgen, Ginette Dionne, Frank Vitaro, Nicholas G Martin, Sarah E Medland, Grant W Montgomery, Youngsook Chong, Gary E Swan, Ruth Krasnow, Patrik Ke Magnusson, Nancy L Pedersen, Per Tynelius, Paul Lichtenstein, Claire Ma Haworth, Robert Plomin, Gombojav Bayasgalan, Danshiitsoodol Narandalai, K Paige Harden, Elliot M Tucker-Drob, Sevgi Y Öncel, Fazil Aliev, Timothy Spector, Massimo Mangino, Genevieve Lachance, Laura A Baker, Catherine Tuvblad, Glen E Duncan, Dedra Buchwald, Gonneke Willemsen, Finn Rasmussen, Jack H Goldberg, Thorkild Ia Sørensen, Dorret I Boomsma, Jaakko Kaprio
BACKGROUND: Both genetic and environmental factors are known to affect body mass index (BMI), but detailed understanding of how their effects differ during childhood and adolescence is lacking. OBJECTIVES: We analyzed the genetic and environmental contributions to BMI variation from infancy to early adulthood and the ways they differ by sex and geographic regions representing high (North America and Australia), moderate (Europe), and low levels (East Asia) of obesogenic environments...
August 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27333805/genetic-and-environmental-influences-on-height-from-infancy-to-early-adulthood-an-individual-based-pooled-analysis-of-45-twin-cohorts
#2
Aline Jelenkovic, Reijo Sund, Yoon-Mi Hur, Yoshie Yokoyama, Jacob V B Hjelmborg, Sören Möller, Chika Honda, Patrik K E Magnusson, Nancy L Pedersen, Syuichi Ooki, Sari Aaltonen, Maria A Stazi, Corrado Fagnani, Cristina D'Ippolito, Duarte L Freitas, José Antonio Maia, Fuling Ji, Feng Ning, Zengchang Pang, Esther Rebato, Andreas Busjahn, Christian Kandler, Kimberly J Saudino, Kerry L Jang, Wendy Cozen, Amie E Hwang, Thomas M Mack, Wenjing Gao, Canqing Yu, Liming Li, Robin P Corley, Brooke M Huibregtse, Catherine A Derom, Robert F Vlietinck, Ruth J F Loos, Kauko Heikkilä, Jane Wardle, Clare H Llewellyn, Abigail Fisher, Tom A McAdams, Thalia C Eley, Alice M Gregory, Mingguang He, Xiaohu Ding, Morten Bjerregaard-Andersen, Henning Beck-Nielsen, Morten Sodemann, Adam D Tarnoki, David L Tarnoki, Ariel Knafo-Noam, David Mankuta, Lior Abramson, S Alexandra Burt, Kelly L Klump, Judy L Silberg, Lindon J Eaves, Hermine H Maes, Robert F Krueger, Matt McGue, Shandell Pahlen, Margaret Gatz, David A Butler, Meike Bartels, Toos C E M van Beijsterveldt, Jeffrey M Craig, Richard Saffery, Lise Dubois, Michel Boivin, Mara Brendgen, Ginette Dionne, Frank Vitaro, Nicholas G Martin, Sarah E Medland, Grant W Montgomery, Gary E Swan, Ruth Krasnow, Per Tynelius, Paul Lichtenstein, Claire M A Haworth, Robert Plomin, Gombojav Bayasgalan, Danshiitsoodol Narandalai, K Paige Harden, Elliot M Tucker-Drob, Timothy Spector, Massimo Mangino, Genevieve Lachance, Laura A Baker, Catherine Tuvblad, Glen E Duncan, Dedra Buchwald, Gonneke Willemsen, Axel Skytthe, Kirsten O Kyvik, Kaare Christensen, Sevgi Y Öncel, Fazil Aliev, Finn Rasmussen, Jack H Goldberg, Thorkild I A Sørensen, Dorret I Boomsma, Jaakko Kaprio, Karri Silventoinen
Height variation is known to be determined by both genetic and environmental factors, but a systematic description of how their influences differ by sex, age and global regions is lacking. We conducted an individual-based pooled analysis of 45 twin cohorts from 20 countries, including 180,520 paired measurements at ages 1-19 years. The proportion of height variation explained by shared environmental factors was greatest in early childhood, but these effects remained present until early adulthood. Accordingly, the relative genetic contribution increased with age and was greatest in adolescence (up to 0...
June 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27097412/-analysis-on-morphological-characteristics-photosynthetic-characteristics-and-chemical-constituents-of-inula-lineariifolia-from-different-populations
#3
COMPARATIVE STUDY
Feng-chen Chen, Chang-lin Wang, Qiao-sheng Guo, Xin Tian, Yuan-yuan Qiu
Twelve populations of Inula lineariifolia were used as materials to measure morphological characteristics, photosynthetic parameters and chemical constituents. It aims to provide a theoretical basis for germplasm resources evaluation. The results showed that I. lineariifolia had relatively rich morphological diversity, there were significant differences of morphological characteristics, photosynthetic parameters and chemical constituents among populations. There was positive correlation on morphological characteristics and P(n)...
November 2015: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/27020472/meta-analysis-of-gene-environment-wide-association-scans-accounting-for-education-level-identifies-additional-loci-for-refractive-error
#4
Qiao Fan, Virginie J M Verhoeven, Robert Wojciechowski, Veluchamy A Barathi, Pirro G Hysi, Jeremy A Guggenheim, René Höhn, Veronique Vitart, Anthony P Khawaja, Kenji Yamashiro, S Mohsen Hosseini, Terho Lehtimäki, Yi Lu, Toomas Haller, Jing Xie, Cécile Delcourt, Mario Pirastu, Juho Wedenoja, Puya Gharahkhani, Cristina Venturini, Masahiro Miyake, Alex W Hewitt, Xiaobo Guo, Johanna Mazur, Jenifer E Huffman, Katie M Williams, Ozren Polasek, Harry Campbell, Igor Rudan, Zoran Vatavuk, James F Wilson, Peter K Joshi, George McMahon, Beate St Pourcain, David M Evans, Claire L Simpson, Tae-Hwi Schwantes-An, Robert P Igo, Alireza Mirshahi, Audrey Cougnard-Gregoire, Céline Bellenguez, Maria Blettner, Olli Raitakari, Mika Kähönen, Ilkka Seppala, Tanja Zeller, Thomas Meitinger, Janina S Ried, Christian Gieger, Laura Portas, Elisabeth M van Leeuwen, Najaf Amin, André G Uitterlinden, Fernando Rivadeneira, Albert Hofman, Johannes R Vingerling, Ya Xing Wang, Xu Wang, Eileen Tai-Hui Boh, M Kamran Ikram, Charumathi Sabanayagam, Preeti Gupta, Vincent Tan, Lei Zhou, Candice E H Ho, Wan'e Lim, Roger W Beuerman, Rosalynn Siantar, E-Shyong Tai, Eranga Vithana, Evelin Mihailov, Chiea-Chuen Khor, Caroline Hayward, Robert N Luben, Paul J Foster, Barbara E K Klein, Ronald Klein, Hoi-Suen Wong, Paul Mitchell, Andres Metspalu, Tin Aung, Terri L Young, Mingguang He, Olavi Pärssinen, Cornelia M van Duijn, Jie Jin Wang, Cathy Williams, Jost B Jonas, Yik-Ying Teo, David A Mackey, Konrad Oexle, Nagahisa Yoshimura, Andrew D Paterson, Norbert Pfeiffer, Tien-Yin Wong, Paul N Baird, Dwight Stambolian, Joan E Bailey Wilson, Ching-Yu Cheng, Christopher J Hammond, Caroline C W Klaver, Seang-Mei Saw, Jugnoo S Rahi, Jean-François Korobelnik, John P Kemp, Nicholas J Timpson, George Davey Smith, Jamie E Craig, Kathryn P Burdon, Rhys D Fogarty, Sudha K Iyengar, Emily Chew, Sarayut Janmahasatian, Nicholas G Martin, Stuart MacGregor, Liang Xu, Maria Schache, Vinay Nangia, Songhomitra Panda-Jonas, Alan F Wright, Jeremy R Fondran, Jonathan H Lass, Sheng Feng, Jing Hua Zhao, Kay-Tee Khaw, Nick J Wareham, Taina Rantanen, Jaakko Kaprio, Chi Pui Pang, Li Jia Chen, Pancy O Tam, Vishal Jhanji, Alvin L Young, Angela Döring, Leslie J Raffel, Mary-Frances Cotch, Xiaohui Li, Shea Ping Yip, Maurice K H Yap, Ginevra Biino, Simona Vaccargiu, Maurizio Fossarello, Brian Fleck, Seyhan Yazar, Jan Willem L Tideman, Milly Tedja, Margaret M Deangelis, Margaux Morrison, Lindsay Farrer, Xiangtian Zhou, Wei Chen, Nobuhisa Mizuki, Akira Meguro, Kari Matti Mäkelä
Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error...
March 29, 2016: Nature Communications
https://www.readbyqxmd.com/read/26996222/twin-s-birth-order-differences-in-height-and-body-mass-index-from-birth-to-old-age-a-pooled-study-of-26-twin-cohorts-participating-in-the-codatwins-project
#5
Yoshie Yokoyama, Aline Jelenkovic, Reijo Sund, Joohon Sung, John L Hopper, Syuichi Ooki, Kauko Heikkilä, Sari Aaltonen, Adam D Tarnoki, David L Tarnoki, Gonneke Willemsen, Meike Bartels, Toos C E M van Beijsterveldt, Kimberly J Saudino, Tessa L Cutler, Tracy L Nelson, Keith E Whitfield, Jane Wardle, Clare H Llewellyn, Abigail Fisher, Mingguang He, Xiaohu Ding, Morten Bjerregaard-Andersen, Henning Beck-Nielsen, Morten Sodemann, Yun-Mi Song, Sarah Yang, Kayoung Lee, Hoe-Uk Jeong, Ariel Knafo-Noam, David Mankuta, Lior Abramson, S Alexandra Burt, Kelly L Klump, Juan R Ordoñana, Juan F Sánchez-Romera, Lucia Colodro-Conde, Jennifer R Harris, Ingunn Brandt, Thomas Sevenius Nilsen, Jeffrey M Craig, Richard Saffery, Fuling Ji, Feng Ning, Zengchang Pang, Lise Dubois, Michel Boivin, Mara Brendgen, Ginette Dionne, Frank Vitaro, Nicholas G Martin, Sarah E Medland, Grant W Montgomery, Patrik K E Magnusson, Nancy L Pedersen, Anna K Dahl Aslan, Per Tynelius, Claire M A Haworth, Robert Plomin, Esther Rebato, Richard J Rose, Jack H Goldberg, Finn Rasmussen, Yoon-Mi Hur, Thorkild I A Sørensen, Dorret I Boomsma, Jaakko Kaprio, Karri Silventoinen
We analyzed birth order differences in means and variances of height and body mass index (BMI) in monozygotic (MZ) and dizygotic (DZ) twins from infancy to old age. The data were derived from the international CODATwins database. The total number of height and BMI measures from 0.5 to 79.5 years of age was 397,466. As expected, first-born twins had greater birth weight than second-born twins. With respect to height, first-born twins were slightly taller than second-born twins in childhood. After adjusting the results for birth weight, the birth order differences decreased and were no longer statistically significant...
April 2016: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/26860982/determination-of-scrub-typhus-suggests-a-new-epidemic-focus-in-the-anhui-province-of-china
#6
Min Cao, Li Che, Jinhai Zhang, Jianli Hu, Swaminath Srinivas, Ruiyao Xu, Henbing Guo, Yun Zhang, Changjun Wang, Youjun Feng
In 2007, 19 cases of a scrub typhus epidemic occurred within a week at a sports school in Mingguang County, Anhui Province, where no previous incidence of this mite borne disease had been reported. Sero-surveillance in 2009 indicated that 10 of the 100 school students possessed anti-Orientia tsutsugamushi antibodies. From 2009 to 2013, 60 small animals and 2250 mites were collected in the vicinity of the school. 5 of the Apodemus agrarius samples and 1 group of Leptotrombidium linhuaikongense tested positive via PCR for O...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26399167/anomalous-structural-transition-and-electrical-transport-behaviors-in-compressed-zn2sno4-effect-of-interface
#7
Haiwa Zhang, Feng Ke, Yan Li, Li Wang, Cailong Liu, Yi Zeng, Mingguang Yao, Yonghao Han, Yanzhang Ma, Chunxiao Gao
The interface effect is one of the most important factors that strongly affect the structural transformations and the properties of nano-/submicro-crystals under pressure. However, characterization of the granular boundary changes in materials is always challenging. Here, using tetrakaidecahedral Zn2SnO4 microcrystals as an example, we employed alternating current impedance, X-ray diffraction methods and transmission electron microscopy to elucidate the effect of the interface on the structure and electrical transport behavior of the Zn2SnO4 material under pressure...
2015: Scientific Reports
https://www.readbyqxmd.com/read/26337138/zygosity-differences-in-height-and-body-mass-index-of-twins-from-infancy-to-old-age-a-study-of-the-codatwins-project
#8
Aline Jelenkovic, Yoshie Yokoyama, Reijo Sund, Chika Honda, Leonie H Bogl, Sari Aaltonen, Fuling Ji, Feng Ning, Zengchang Pang, Juan R Ordoñana, Juan F Sánchez-Romera, Lucia Colodro-Conde, S Alexandra Burt, Kelly L Klump, Sarah E Medland, Grant W Montgomery, Christian Kandler, Tom A McAdams, Thalia C Eley, Alice M Gregory, Kimberly J Saudino, Lise Dubois, Michel Boivin, Adam D Tarnoki, David L Tarnoki, Claire M A Haworth, Robert Plomin, Sevgi Y Öncel, Fazil Aliev, Maria A Stazi, Corrado Fagnani, Cristina D'Ippolito, Jeffrey M Craig, Richard Saffery, Sisira H Siribaddana, Matthew Hotopf, Athula Sumathipala, Fruhling Rijsdijk, Timothy Spector, Massimo Mangino, Genevieve Lachance, Margaret Gatz, David A Butler, Gombojav Bayasgalan, Danshiitsoodol Narandalai, Duarte L Freitas, José Antonio Maia, K Paige Harden, Elliot M Tucker-Drob, Bia Kim, Youngsook Chong, Changhee Hong, Hyun Jung Shin, Kaare Christensen, Axel Skytthe, Kirsten O Kyvik, Catherine A Derom, Robert F Vlietinck, Ruth J F Loos, Wendy Cozen, Amie E Hwang, Thomas M Mack, Mingguang He, Xiaohu Ding, Billy Chang, Judy L Silberg, Lindon J Eaves, Hermine H Maes, Tessa L Cutler, John L Hopper, Kelly Aujard, Patrik K E Magnusson, Nancy L Pedersen, Anna K Dahl Aslan, Yun-Mi Song, Sarah Yang, Kayoung Lee, Laura A Baker, Catherine Tuvblad, Morten Bjerregaard-Andersen, Henning Beck-Nielsen, Morten Sodemann, Kauko Heikkilä, Qihua Tan, Dongfeng Zhang, Gary E Swan, Ruth Krasnow, Kerry L Jang, Ariel Knafo-Noam, David Mankuta, Lior Abramson, Paul Lichtenstein, Robert F Krueger, Matt McGue, Shandell Pahlen, Per Tynelius, Glen E Duncan, Dedra Buchwald, Robin P Corley, Brooke M Huibregtse, Tracy L Nelson, Keith E Whitfield, Carol E Franz, William S Kremen, Michael J Lyons, Syuichi Ooki, Ingunn Brandt, Thomas Sevenius Nilsen, Fujio Inui, Mikio Watanabe, Meike Bartels, Toos C E M van Beijsterveldt, Jane Wardle, Clare H Llewellyn, Abigail Fisher, Esther Rebato, Nicholas G Martin, Yoshinori Iwatani, Kazuo Hayakawa, Joohon Sung, Jennifer R Harris, Gonneke Willemsen, Andreas Busjahn, Jack H Goldberg, Finn Rasmussen, Yoon-Mi Hur, Dorret I Boomsma, Thorkild I A Sørensen, Jaakko Kaprio, Karri Silventoinen
A trend toward greater body size in dizygotic (DZ) than in monozygotic (MZ) twins has been suggested by some but not all studies, and this difference may also vary by age. We analyzed zygosity differences in mean values and variances of height and body mass index (BMI) among male and female twins from infancy to old age. Data were derived from an international database of 54 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins), and included 842,951 height and BMI measurements from twins aged 1 to 102 years...
October 2015: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/26266349/a-new-insight-into-sudden-cardiac-death-in-young-people-a-systematic-review-of-cases-of-takotsubo-cardiomyopathy
#9
REVIEW
Yueyue Wang, Lei Xia, Xiaodong Shen, Guoxin Han, Dan Feng, Hongju Xiao, Yongzhi Zhai, Xin Chen, Yuanyuan Miao, Chunhong Zhao, Yingchan Wang, Mingguang Guo, Tanshi Li, Hai Yan Zhu
Takotsubo cardiomyopathy (TTC) causes sudden cardiac death and has garnered increased attention worldwide in recent years. However, few studies have clearly classified the risk factors for this disease, including gender, race and morbidity, as well as the physical and mental stressors that can exacerbate the disease, particularly in young patients. To better analyze the characteristics of young TTC patients, we performed a systematic review of reported cases involving young patients.A computer-assisted search was performed using prominent electronic medical information sources to identify literature published between January 1965 and December 2013...
August 2015: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26014041/the-codatwins-project-the-cohort-description-of-collaborative-project-of-development-of-anthropometrical-measures-in-twins-to-study-macro-environmental-variation-in-genetic-and-environmental-effects-on-anthropometric-traits
#10
Karri Silventoinen, Aline Jelenkovic, Reijo Sund, Chika Honda, Sari Aaltonen, Yoshie Yokoyama, Adam D Tarnoki, David L Tarnoki, Feng Ning, Fuling Ji, Zengchang Pang, Juan R Ordoñana, Juan F Sánchez-Romera, Lucia Colodro-Conde, S Alexandra Burt, Kelly L Klump, Sarah E Medland, Grant W Montgomery, Christian Kandler, Tom A McAdams, Thalia C Eley, Alice M Gregory, Kimberly J Saudino, Lise Dubois, Michel Boivin, Claire M A Haworth, Robert Plomin, Sevgi Y Öncel, Fazil Aliev, Maria A Stazi, Corrado Fagnani, Cristina D'Ippolito, Jeffrey M Craig, Richard Saffery, Sisira H Siribaddana, Matthew Hotopf, Athula Sumathipala, Timothy Spector, Massimo Mangino, Genevieve Lachance, Margaret Gatz, David A Butler, Gombojav Bayasgalan, Danshiitsoodol Narandalai, Duarte L Freitas, José Antonio Maia, K Paige Harden, Elliot M Tucker-Drob, Kaare Christensen, Axel Skytthe, Kirsten O Kyvik, Changhee Hong, Youngsook Chong, Catherine A Derom, Robert F Vlietinck, Ruth J F Loos, Wendy Cozen, Amie E Hwang, Thomas M Mack, Mingguang He, Xiaohu Ding, Billy Chang, Judy L Silberg, Lindon J Eaves, Hermine H Maes, Tessa L Cutler, John L Hopper, Kelly Aujard, Patrik K E Magnusson, Nancy L Pedersen, Anna K Dahl Aslan, Yun-Mi Song, Sarah Yang, Kayoung Lee, Laura A Baker, Catherine Tuvblad, Morten Bjerregaard-Andersen, Henning Beck-Nielsen, Morten Sodemann, Kauko Heikkilä, Qihua Tan, Dongfeng Zhang, Gary E Swan, Ruth Krasnow, Kerry L Jang, Ariel Knafo-Noam, David Mankuta, Lior Abramson, Paul Lichtenstein, Robert F Krueger, Matt McGue, Shandell Pahlen, Per Tynelius, Glen E Duncan, Dedra Buchwald, Robin P Corley, Brooke M Huibregtse, Tracy L Nelson, Keith E Whitfield, Carol E Franz, William S Kremen, Michael J Lyons, Syuichi Ooki, Ingunn Brandt, Thomas Sevenius Nilsen, Fujio Inui, Mikio Watanabe, Meike Bartels, Toos C E M van Beijsterveldt, Jane Wardle, Clare H Llewellyn, Abigail Fisher, Esther Rebato, Nicholas G Martin, Yoshinori Iwatani, Kazuo Hayakawa, Finn Rasmussen, Joohon Sung, Jennifer R Harris, Gonneke Willemsen, Andreas Busjahn, Jack H Goldberg, Dorret I Boomsma, Yoon-Mi Hur, Thorkild I A Sørensen, Jaakko Kaprio
For over 100 years, the genetics of human anthropometric traits has attracted scientific interest. In particular, height and body mass index (BMI, calculated as kg/m2) have been under intensive genetic research. However, it is still largely unknown whether and how heritability estimates vary between human populations. Opportunities to address this question have increased recently because of the establishment of many new twin cohorts and the increasing accumulation of data in established twin cohorts. We started a new research project to analyze systematically (1) the variation of heritability estimates of height, BMI and their trajectories over the life course between birth cohorts, ethnicities and countries, and (2) to study the effects of birth-related factors, education and smoking on these anthropometric traits and whether these effects vary between twin cohorts...
August 2015: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/24382352/sustained-activation-of-smad3-smad4-by-foxm1-promotes-tgf-%C3%AE-dependent-cancer-metastasis
#11
Jianfei Xue, Xia Lin, Wen-Tai Chiu, Yao-Hui Chen, Guanzhen Yu, Mingguang Liu, Xin-Hua Feng, Raymond Sawaya, René H Medema, Mien-Chie Hung, Suyun Huang
A key feature of TGF-β signaling activation in cancer cells is the sustained activation of SMAD complexes in the nucleus; however, the drivers of SMAD activation are poorly defined. Here, using human and mouse breast cancer cell lines, we found that oncogene forkhead box M1 (FOXM1) interacts with SMAD3 to sustain activation of the SMAD3/SMAD4 complex in the nucleus. FOXM1 prevented the E3 ubiquitin-protein ligase transcriptional intermediary factor 1 γ (TIF1γ) from binding SMAD3 and monoubiquitinating SMAD4, which stabilized the SMAD3/SMAD4 complex...
February 2014: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/23614237/-antioxidation-and-multidrug-resistance-of-structure-similar-atp-binding-cassette-transporter-proteins-in-two-fungal-entomopathogens
#12
Jing Zhao, Tingting Song, Shenghua Ying, Mingguang Feng
OBJECTIVE: Structure-similar ATP-binding cassette (ABC) transporter proteins, BbT1 in Beauveria bassiana (Bb) and IfT1 in Isaria fumosorosea (If), were characterized. METHODS: Various phenotypes including cellular antioxidant response, multidrug resistance and virulence were compared between wild-type strain and the constructed mutants DeltaBbT1, DeltaBbT1/BbT1 and DBbT1/IfT1. RESULTS: Compared with the wild-type, DeltaBbT1/BbT1 and DeltaBbT1/ IfT1 strains showing no significant changes in examined phenotypes, DeltaBbT1 became 27% to 2...
January 4, 2013: Wei Sheng Wu Xue Bao, Acta Microbiologica Sinica
https://www.readbyqxmd.com/read/23485253/diagnosis-and-surgical-treatment-of-sporadic-meningioangiomatosis
#13
Rui Feng, Jie Hu, Xiaoming Che, Li Pan, Zhiqiu Wang, Mingguang Zhang, Fengping Huang, Bin Xu, Renling Mao, An Sun, Weimin Bao, Ping Zhong, Yin Wang
OBJECTIVE: To discuss the clinical characteristics, radiological features, surgical treatment and prognosis of sporadic meningioangiomatosis (MA). METHODS: We retrospectively analyzed the medical records of ten histopathologically confirmed MA patients who were treated in the Department of Neurosurgery of Huashan hospital from 2002 to 2011. All of the patients presented with symptomatic seizure attacks before craniotomy surgeries. Magnetic resonance imaging (MRI) and/or computed tomography (CT) were the main radiological examination for preoperative diagnosis of all cases...
August 2013: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/22769051/synthesis-of-nitrogen-doped-porous-carbon-nanofibers-as-an-efficient-electrode-material-for-supercapacitors
#14
Li-Feng Chen, Xu-Dong Zhang, Hai-Wei Liang, Mingguang Kong, Qing-Fang Guan, Ping Chen, Zhen-Yu Wu, Shu-Hong Yu
Supercapacitors (also known as ultracapacitors) are considered to be the most promising approach to meet the pressing requirements of energy storage. Supercapacitive electrode materials, which are closely related to the high-efficiency storage of energy, have provoked more interest. Herein, we present a high-capacity supercapacitor material based on the nitrogen-doped porous carbon nanofibers synthesized by carbonization of macroscopic-scale carbonaceous nanofibers (CNFs) coated with polypyrrole (CNFs@polypyrrole) at an appropriate temperature...
August 28, 2012: ACS Nano
https://www.readbyqxmd.com/read/21220630/shared-genetic-determinants-of-axial-length-and-height-in-children-the-guangzhou-twin-eye-study
#15
Jian Zhang, Yoon-Mi Hur, Wenyong Huang, Xiaohu Ding, Ke Feng, Mingguang He
OBJECTIVES: To describe the association between axial length (AL) and height and to estimate the extent to which shared genetic or environmental factors influence this covariance. METHODS: Study participants were recruited from the Guangzhou Twin Registry. Axial length was measured using partial coherence laser interferometry. Height was measured with the participants standing without shoes. We computed twin pairwise correlations and cross-twin cross-trait correlations between AL and height for monozygotic and dizygotic twins and performed model-fitting analyses using a multivariate Cholesky model...
January 2011: Archives of Ophthalmology
https://www.readbyqxmd.com/read/20536267/lead-in-children-s-blood-is-mainly-caused-by-coal-fired-ash-after-phasing-out-of-leaded-gasoline-in-shanghai
#16
Feng Liang, Guilin Zhang, Mingguang Tan, Chonghuai Yan, Xiaolin Li, Yulan Li, Yan Li, Yuanmao Zhang, Zuci Shan
Lead (Pb) is a highly toxic element to the human body. After phasing out of leaded gasoline we find that the blood lead level of children strongly correlates with the lead concentration in atmospheric particles, and the latter correlates with the coal consumption instead of leaded gasoline. Combined with the (207)Pb/(206)Pb ratio measurements, we find that the coal consumption fly ash is a dominate source of Pb exposure to children in Shanghai, rather than vehicle exhaust, metallurgic dust, paint dust, and drinking water...
June 15, 2010: Environmental Science & Technology
https://www.readbyqxmd.com/read/20485999/total-and-speciated-arsenic-levels-in-rice-from-china
#17
Feng Liang, Yulan Li, Guilin Zhang, Mingguang Tan, Jun Lin, Wei Liu, Yan Li, Wenwei Lu
Although the need for policy development on arsenic (As) in rice has been recognized and a legally enforceable maximum contaminant level (MCL) for inorganic arsenic (As(i)) in rice has been established in China, evidence reported in this article indicates that the risk of exposure to As for the Chinese population through rice is still underestimated. Polished rice from various production regions of China was analyzed for total As and arsenic species using HPLC-ICPMS. Total As concentration ranged 65.3-274.2 ng g(-1), with an average value of 114...
June 2010: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/17380344/effects-induced-by-kev-low-energy-ion-irradiation-in-the-nematode-caenorhabditis-elegans
#18
Xuelan Liu, Kezhou Cai, Huiyun Feng, Hang Yuan, Mingguang Kong, Lijun Wu, Yuejin Wu, Zengliang Yu
The nematode Caenorhabditis elegans is an excellent model organism with which to study the biological effects and mechanisms of ionizing irradiation. In this study, using C. elegans as a model, the effects of keV low-energy argon ion irradiation were investigated, by examining cuticle damage, worm survival, brood size, life span, and germ cell death. The surface etching of worm cuticle after ion impact was investigated by trypan blue staining and SEM microscopy. The degree of damage increased with ion fluence (2 x 10(14) to 7 x 10(14) ions cm(-2)) and energy (5-25 keV)...
August 2007: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/17044504/-compatibility-of-two-fungal-biocontrol-agents-conidia-with-commercial-chemical-acaricides
#19
Yu Jiang, Mingguang Feng
In this paper, the biological compatibility of fungal biocontrol agents Beauveria bassiana and Paecilomyces fumosoroseus conidia with 10 commercial chemical acaricides were assayed, based on the conidial germination rates in nutritional liquid and on SDAY plate. The results showed that nutritional liquid was more available than SDAY plate in the assay. So far as the 24 h conidial viability concerned, there were significant differences among the test acaricides with the concentrations of recommended for field spray and 5 and 10 fold dilutions, as well as between the two fungal agents...
July 2006: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/16706360/-a-mechanical-model-of-knee-joint-in-sagittal-plane
#20
Yujue He, Mingguang Feng, Changming Xu, Chengtao Wang
A sagittal plane model of knee joint based on crossed-four-bar-linkage-based tibiofemoral joint model has been developed using geometric and force equilibrium constraints. The model predicts and explains the movement of contact point on the patella and femur, variation of patellar and patellar tendon angle, variation of patellar mechanism angle and variation of patellofemoral contact force and patellar tendon force. The computed results agree well with the published experimental results.
April 2006: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
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