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https://www.readbyqxmd.com/read/29471041/mechanically-activated-ion-channels
#1
Boris Martinac, Kate Poole
The ability of cells to sense and respond to their physical environment is fundamental to a broad spectrum of biological processes. Cells express an array of force sensors that can transduce mechanical inputs into biochemical signals, including the mechanically activated ion channels PIEZO1, PIEZO2 and TRPV4. The identification and characterisation of mechanically activated ion channels has proven challenging, as has identifying their mode of activation and regulation in vivo. However, the diverse channelopathies associated with the known channels highlights their physiological importance...
February 19, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29470837/past-present-and-future-approaches-to-the-prevention-and-treatment-of-respiratory-syncytial-virus-infection-in-children
#2
REVIEW
Eric A F Simões, Louis Bont, Paolo Manzoni, Brigitte Fauroux, Bosco Paes, Josep Figueras-Aloy, Paul A Checchia, Xavier Carbonell-Estrany
INTRODUCTION: The REGAL (RSV Evidence - A Geographical Archive of the Literature) series has provided a comprehensive review of the published evidence in the field of respiratory syncytial virus (RSV) in Western countries over the last 20 years. This seventh and final publication covers the past, present and future approaches to the prevention and treatment of RSV infection among infants and children. METHODS: A systematic review was undertaken of publications between January 1, 1995 and December 31, 2017 across PubMed, Embase and The Cochrane Library...
February 22, 2018: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/29470668/indoor-environmental-interventions-and-their-effect-on-asthma-outcomes
#3
REVIEW
Rebin Kader, Kevin Kennedy, Jay M Portnoy
PURPOSE OF REVIEW: The use of environmental interventions to improve outcomes in asthmatics has long been an elusive goal. While numerous interventions have been studied, the results of clinical trials have been mixed. This review aims to identify combinations of interventions that have been proven to be effective and to propose a model for using them in a clinical setting. RECENT FINDINGS: An NIH workshop emphasized a need for research to identify effective interventions for reducing indoor exposures and improving asthma outcomes...
February 22, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29470647/dopaminergic-innervation-and-modulation-of-hippocampal-networks
#4
REVIEW
Elke Edelmann, Volkmar Lessmann
The catecholamine dopamine plays an important role in hippocampus-dependent plasticity and related learning and memory processes. Dopamine secretion in the hippocampus is activated by, e.g., salient or novel stimuli, thereby helping to establish and to stabilize hippocampus-dependent memories. Disturbed dopaminergic function in the hippocampus leads to severe pathophysiological conditions. While the role and importance of dopaminergic modulation of hippocampal networks have been unequivocally proven, there is still a lack of detailed molecular and cellular mechanistic understanding of how dopamine orchestrates these hippocampal processes...
February 22, 2018: Cell and Tissue Research
https://www.readbyqxmd.com/read/29470619/exploring-the-sequence-diversity-in-glycoside-hydrolase-family-13_18-reveals-a-novel-glucosylglycerol-phosphorylase
#5
Jorick Franceus, Lena Decuyper, Matthias D'hooghe, Tom Desmet
In the carbohydrate-active enzyme database, GH13_18 is a family of retaining glycoside phosphorylases that act on α-glucosides. In this work, we explored the functional diversity of this family by comparing distinctive sequence motifs in different branches of its phylogenetic tree. A glycoside phosphorylase from Marinobacter adhaerens HP15 that was predicted to have a novel function was expressed and characterised. The enzyme was found to catalyse the reversible phosphorolysis of 2-O-α-D-glucosylglycerol with retention of the anomeric configuration, a specificity that has never been described before...
February 22, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29470458/prevalence-of-amyotrophic-lateral-sclerosis-united-states-2014
#6
Paul Mehta, Wendy Kaye, Jaime Raymond, Ruoming Wu, Theodore Larson, Reshma Punjani, Daniel Heller, Jessica Cohen, Tracy Peters, Oleg Muravov, Kevin Horton
Amyotrophic lateral sclerosis (ALS), commonly known as Lou Gehrig's disease, is a progressive and fatal neuromuscular disease; the majority of ALS patients die within 2-5 years of receiving a diagnosis (1). Familial ALS, a hereditary form of the disease, accounts for 5%-10% of cases, whereas the remaining sporadic cases have no clearly defined etiology (1). ALS affects persons of all races and ethnicities; however, whites, males, non-Hispanics, persons aged >60 years, and those with a family history of ALS are more likely to develop the disease (1-3)...
February 23, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29470453/uhplc-uv-method-for-simultaneous-determination-of-perindopril-arginine-and-indapamide-hemihydrate-in-combined-dosage-form-a-stability-indicating-assay-method
#7
Naser F Al-Tannak
Perindopril arginine and Indapamide hemihydrate in combination were proven to have a synergistic antihypertensive impact when compared with the use of each component alone. Therefore, a new Ultra-High Performance Liquid Chromatography coupled with Ultraviolet detector (UHPLC-UV) method has been developed and subsequently validated for simultaneous determination of the anti-hypertensive combination of Perindopril arginine and Indapamide hemihydrate. The separation of Perindopril arginine and Indapamide hemihydrate was achieved using a BEH C18 (1...
February 22, 2018: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/29470443/structure-antiplatelet-activity-relationships-of-novel-ruthenium-ii-complexes-investigation-of-its-molecular-targets
#8
Chih-Hsuan Hsia, Thanasekaran Jayakumar, Joen-Rong Sheu, Shin-Yi Tsao, Marappan Velusamy, Chih-Wei Hsia, Duen-Suey Chou, Chao-Chien Chang, Chi-Li Chung, Themmila Khamrang, Kao-Chang Lin
The regulation of platelet function by pharmacological agents that modulate platelet signaling has proven to be a positive approach to the prevention of thrombosis. Ruthenium complexes are fascinating for the development of new drugs, as they possess numerous chemical and biological properties. The present study aims to evaluate the structure-activity relationship (SAR) of newly synthesized ruthenium (II) complexes, TQ-1, TQ-2 and TQ-3 in agonists-induced washed human platelets. Silica gel column chromatography, aggregometry, immunoblotting, NMR, and X-ray analyses were performed in this study...
February 22, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29470286/genetic-variants-associated-with-obesity-and-insulin-resistance-in-hispanic-boys-with-nonalcoholic-fatty-liver-disease
#9
John C Rausch, Joel E Lavine, Naga Chalasani, Xiuqing Guo, Soonil Kwon, Jeffrey B Schwimmer, Jean P Molleston, Rohit Loomba, Elizabeth M Brunt, Yii-Der Ida Chen, Mark O Goodarzi, Kent D Taylor, Katherine P Yates, Jerome I Rotter
BACKGROUND AND OBJECTIVES: Nonalcoholic fatty liver disease (NAFLD) disproportionately affects Hispanic boys. Further, obesity and insulin resistance are major risk factors for NAFLD. No gene localization studies had been performed on children with biopsy-proven NAFLD. This study aims to identify genomic variants associated with increased adiposity and insulin resistance in a population of children with varying histologic severity of NAFLD. METHODS: We conducted a genome-wide association scan (GWAS) including 624,297 single-nucleotide polymorphisms (SNPs) distributed among all 22 autosomal chromosomes in 234 Hispanic boys (up to 18 years of age) who were consecutively recruited in a prospective cohort study in the Nonalcoholic Steatohepatitis Clinical Research Network Studies...
February 21, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29470157/solid-small-renal-mass-without-gross-fat-ct-criteria-for-achieving-excellent-positive-predictive-value-for-renal-cell-carcinoma
#10
Sung Yoon Park, Su-Jin Shin, Nam Hoon Cho, Dae Chul Jung, Koon Ho Rha, Woong Kyu Han, Young Taik Oh
OBJECTIVE: The purpose of this study was to evaluate CT criteria for achieving high positive predictive value (PPV) for renal cell carcinoma (RCC) in patients with solid small renal masses (SRMs) less than 4 cm without macroscopic fat. MATERIALS AND METHODS: One hundred fifty consecutive patients with a solid SRM without macroscopic fat (mean size ± SD, 2.5 ± 0.8 cm) who underwent CT including unenhanced, corticomedullary (CMP), and nephrographic phases (NP) were evaluated...
February 22, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29469892/adjustable-focus-ultracompact-endoscopic-lens-design-with-ultrahigh-optical-performance
#11
Yu-Shan Chang, Long Hsu, Kuang-Lung Huang
An internally focusing design is developed for a compact endoscopic lens to have optical performance close to the diffraction limit. When changing the working distance from infinity to a predetermined short distance, the overall system length and the field of view remain constant. It is numerically demonstrated that the diffraction-limit-like performance is maintained over a wide range of working distances, showing a novel capability of adjustable focuses. The design concept is numerically proven to be feasible and can enable very high-resolution examination for doctors checking the positions of biological entities through the immediate capture of clear images at different working distances...
February 10, 2018: Applied Optics
https://www.readbyqxmd.com/read/29469881/accurate-estimation-of-the-illumination-pattern-s-orientation-and-wavelength-in-sinusoidal-structured-illumination-microscopy
#12
Marcel Lahrberg, Mandeep Singh, Kedar Khare, Balpreet Singh Ahluwalia
Structured illumination microscopy is able to improve the spatial resolution of wide-field fluorescence imaging by applying sinusoidal stripe pattern illumination to the sample. The corresponding computational image reconstruction requires precise knowledge of the pattern's parameters, which are its phase (ϕ) and wave vector (p). Here, a computationally inexpensive method for estimation of p from the raw data is proposed and illustrated with simulations. The method estimates p through a selective discrete Fourier transform at tunable subpixel precision...
February 10, 2018: Applied Optics
https://www.readbyqxmd.com/read/29469825/performance-analysis-of-an-optical-self-interference-cancellation-system-with-a-directly-modulated-laser-based-demonstration
#13
Yinghong Yu, Yunhao Zhang, Lin Huang, Shilin Xiao
In this paper, two main performance indices of the optical self-interference cancellation (OSIC) system are theoretically analyzed: cancellation bandwidth and depth. Delay deviation is investigated to be the determining factor of cancellation bandwidth, based on which the bandwidth advantage of the OSIC system over electrical schemes is also proven theoretically. Cancellation depth in the narrowband is mostly influenced by attenuation and delay-adjusting deviation, while in the broadband case, the performance is mostly limited by frequency-dependent amplitude and phase mismatch...
February 20, 2018: Applied Optics
https://www.readbyqxmd.com/read/29469793/lesiones-subcut%C3%A3-neas-dolorosas-en-paciente-con-melanoma-metast%C3%A3-sico-un-caso-de-paniculitis-linfoc%C3%A3-tica-asociado-a-vemurafenib
#14
Felipe Benavente-Villegas, Francisco Ferrando-Roca, Raquel Dolz-Gaitón, María Royo-Peiró
Vemurafenib ha probado ser una herramienta útil en el tratamiento de melanoma metastásico con mutación BRAF-V600E. Los efectos adversos incluyen artralgias, fatiga y toxicidad cutánea, siendo infrecuente la paniculitis. Presentamos el caso de una paciente de 43 años con melanoma metastásico que desarrolla lesiones subcutáneas dolorosas en miembros inferiores y superiores, asociadas a clínica sistémica después de 2 semanas de inicio de tratamiento con Vemurafenib + Cobimetinib. La histología demostró paniculitis linfocitaria septal y lobulillar...
October 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469735/quantitative-abcd-parameters-measured-by-a-multispectral-digital-skin-lesion-analysis-device-for-evaluation-of-suspicious-pigmented-skin-lesions-strongly-correlate-with-clinical-abcd-observations
#15
Alex M Glazer, Aaron S Farberg, Richard R Winkelmann, Natalie Tucker, Darrell S Rigel
Background/Study Aim: A multispectral digital skin lesion analysis (MSDSLA) device has proven to be sensitive and specific for malignant melanoma (MM) detection by dermatologists and may have other useful applications. This study aimed to develop and test objective quantitative Asymmetry, Border irregularity, Color, and Diameter (qABCD) parameters for MSDSLA and correlate them with the presence of clinical ABCD features to aid the decision to biopsy a suspicious pigmented skin lesions (PSLs). METHODS: 1632 benign and malignant [175 MM/High Grade Dysplastic Nevi (HGDN)] were evaluated for their qABCD parameters...
August 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469692/the-role-of-interleukin-17-in-the-pathogenesis-of-hidradenitis-suppurativa
#16
Yiqiu Yao, Simon Francis Thomsen
Hidradenitis suppurativa is a chronic inflammatory skin condition affecting primarily the axillary, perianal, and inguinal areas. Patients with hidradenitis suppurativa present with occlusion and subsequent rupture of follicular ducts, profound abscesses, fistulae, odorous discharge, fibrosis, and scar formation, causing significant morbidity. Knowledge of the pathogenesis of hidradenitis suppurativa is limited and treatment with antimicrobial drugs, immunosuppressants, and surgical procedures have shown varying results...
July 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469015/do-celiac-disease-and-non-celiac-gluten-sensitivity-have-the-same-effects-on-reproductive-disorders
#17
REVIEW
Joanna Pieczyńska
OBJECTIVES: The wide spectrum of clinical symptoms of celiac disease (CD) is partly due to the malnourished state caused by the malabsorption of micro- and macronutrients. It has been suggested that fertility problems and obstetric complications may be a consequence of the endocrine disorders caused by selective nutrient deficiencies. The same selective nutrient deficiencies as in CD could be a reason for fertility problems in non-celiac gluten sensitivity (NCGS). The aim of this study was to investigate the effect of nutrient deficiencies in CD and NCGS on fertility problems...
December 8, 2017: Nutrition
https://www.readbyqxmd.com/read/29468938/latin-american-social-medicine-across-borders-south-south-cooperation-and-the-making-of-health-solidarity
#18
Anne-Emanuelle Birn, Carles Muntaner
Latin American social medicine efforts are typically understood as national endeavours, involving health workers, policymakers, academics, social movements, unions, and left-wing political parties, among other domestic actors. But Latin America's social medicine trajectory has also encompassed considerable between-country solidarity, building on early twentieth century interchanges among a range of players who shared approaches for improving living and working conditions and instituting protective social policies...
February 22, 2018: Global Public Health
https://www.readbyqxmd.com/read/29468798/tension-free-vaginal-tape-for-treatment-of-pure-urodynamic-stress-urinary-incontinence-efficacy-and-adverse-effects-at-17-year-follow-up
#19
Andrea Braga, Giorgio Caccia, Paola Sorice, Simona Cantaluppi, Anna Chiara Coluccia, Maria Carmela Di Dedda, Luca Regusci, Fabio Ghezzi, Stefano Uccella, Maurizio Serati
OBJECTIVE: To assess the efficacy and safety of retropubic tension-free vaginal tape (TVT) 17 years after implantation for the treatment of female pure stress urinary incontinence (SUI). PATIENTS AND METHODS: A prospective study was conducted in two urogynaecological units in two countries. All consecutive women with urodynamically proven pure SUI treated by TVT were included. Patients with mixed incontinence and/or anatomical evidence of pelvic organ prolapse were excluded...
February 22, 2018: BJU International
https://www.readbyqxmd.com/read/29468288/efficacy-of-mechanical-thrombectomy-using-stent-retriever-and-balloon-guiding-catheter
#20
S Kammerer, R du Mesnil de Rochemont, M Wagner, S -J You, S Tritt, M Mueller-Eschner, F C Keil, A Lauer, J Berkefeld
PURPOSE: Intra-arterial therapy of acute ischemic stroke has developed rapidly in recent years. Due to proven efficacy in randomized trials, stent retrievers were replacing first-generation thrombectomy devices and have been defined as method of choice. However, aspiration catheters or a combination of several techniques have shown promising rates of successful recanalizations. To create a basis for comparison of the new approaches according to real-world data, we determined the first pass recanalization rate of an evidence-based standard technique with the use of a stent retriever in combination with a balloon-guiding catheter...
February 21, 2018: Cardiovascular and Interventional Radiology
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