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https://www.readbyqxmd.com/read/29245055/high-proportion-of-abnormal-pap-smear-tests-and-cervical-dysplasia-in-women-with-cystic-fibrosis
#1
Christine Rousset-Jablonski, Quitterie Reynaud, Raphaëlle Nove-Josserand, Isabelle Ray-Coquard, Yahia Mekki, François Golfier, Isabelle Durieu
OBJECTIVES: Insufficient gynecological follow-up and cervical screening has been reported in women with cystic fibrosis (CF). Some of these patients will require a pulmonary transplantation, known to be associated with a higher risk of cervical dysplasia. The aim of this study was to explore the results of cervical screening in adult women with CF, and to report the prevalence of abnormal pap smear tests in this population. STUDY DESIGN: We retrospectively analyzed medical records of sexually active women with CF who attended a gynecological consultation in Lyon University CF referral center between June 2014 and December 2015...
December 9, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29244742/fibrinogen-gamma-chain-mutations-provoke-fibrinogen-and-apolipoprotein-b-plasma-deficiency-and-liver-storage
#2
Francesco Callea, Isabella Giovannoni, Sinan Sari, Esendagli Guldal, Buket Dalgic, Gulen Akyol, Tsuyoshi Sogo, Abdulrahman Al-Hussaini, Giuseppe Maggiore, Andrea Bartuli, Renata Boldrini, Paola Francalanci, Emanuele Bellacchio
p.R375W (Fibrinogen Aguadilla) is one out of seven identified mutations (Brescia, Aguadilla, Angers, Al du Pont, Pisa, Beograd, and Ankara) causing hepatic storage of the mutant fibrinogen γ. The Aguadilla mutation has been reported in children from the Caribbean, Europe, Japan, Saudi Arabia, Turkey, and China. All reported children presented with a variable degree of histologically proven chronic liver disease and low plasma fibrinogen levels. In addition, one Japanese and one Turkish child had concomitant hypo-APOB-lipoproteinemia of unknown origin...
December 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29244675/high-pressure-injection-injury-caused-by-electronic-cigarette-explosion-a-case-report
#3
Ian Foran, Nikhil R Oak, Matthew J Meunier
CASE: Electronic cigarettes are an increasingly popular and poorly regulated alternative to traditional cigarettes that deliver nicotine and other aerosolized substances to the user via a battery-powered atomizer. We report a case in which an electronic cigarette explosion resulted in a high-pressure injection injury of the finger. CONCLUSION: Explosions involving electronic cigarettes and similar handheld products should be treated as high-pressure injection injuries until proven otherwise...
April 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29244240/b-cell-therapy-for-multiple-sclerosis-entering-an-era
#4
REVIEW
Ariele L Greenfield, Stephen L Hauser
Monoclonal antibodies that target CD20 expressing B cells represent an important new treatment option for patients with multiple sclerosis (MS). B cell depleting therapy is highly effective against relapsing forms of the disease, and is also the first treatment approach proven to protect against disability worsening in primary progressive MS. Moreover, evolving clinical experience with B cell therapy, combined with a more sophisticated understanding of humoral immunity in preclinical models and in patients with MS, have led to major progress in deciphering the immune pathogenesis of MS...
December 15, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29244172/human-in-vitro-spermatogenesis-from-pluripotent-stem-cells-in-need-of-a-stepwise-differentiation-protocol
#5
C Rombaut, H Mertes, B Heindryckx, E Goossens
Recently, complete in-vitro generation of male gametes starting from pluripotent stem cells was obtained in a mouse model with live offspring as a result. This breakthrough was probably due to the use of a stepwise differentiation protocol taking the tightly regulated in-vivo situation into account. As shown previously, factors of the TGFβ superfamily, metabolites of vitamin A, growth hormones, sex steroids and, most importantly, somatic cell support are major regulators of the development, survival, proliferation and differentiation of male gametes...
December 13, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29244144/species-composition-of-sand-flies-diptera-psychodidae-and-modeling-the-spatial-distribution-of-main-vectors-of-cutaneous-leishmaniasis-in-hormozgan-province-southern-iran
#6
Ahmad Ali Hanafi-Bojd, Mehdi Khoobdel, Moussa Soleimani-Ahmadi, Kourosh Azizi, Abbas Aghaei Afshar, Seyed Aghil Jaberhashemi, Sajjad Fekri, Reza Safari
Cutaneous Leishmaniasis (CL) is one of the main neglected vector-borne diseases in the Middle East, including Iran. This study aimed to map the spatial distribution and species composition of sand flies in Hormozgan Province and to predict the best ecological niches for main CL vectors in this area. A database that included all earlier studies on sand flies in Hormozgan Province was established. Sand flies were also collected from some localities across the province. Prediction maps for main vectors were developed using MaxEnt model...
December 13, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29243849/therapeutic-patient-education-in-children-with-moderate-to-severe-atopic-dermatitis-a-multicenter-randomized-controlled-trial-in-china
#7
Yuan Liang, Jing Tian, Chun Ping Shen, Feng Xu, Hua Wang, Ping Li, Yan Ping Guo, Feng Lei Wei, Lin Ma
BACKGROUND: Therapeutic patient education is a continuous, systematic, patient-centered learning process to help patients and their families acquire and maintain the skills they need to manage their lives with a chronic disease. It has been proven effective in increasing treatment adherence and improving quality of life for patients with atopic dermatitis (AD) in Western countries. We introduce the first multicenter, randomized controlled clinical trial of therapeutic patient education in Chinese children with AD...
December 15, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29243801/adverse-reactions-to-denture-resin-materials
#8
M Kostic, A Pejcic, M Igic, N Gligorijevic
Irrespective of the new generation of dental materials, acrylates still have a wide indication field. Although they are classified as biomaterials, acrylates can have both local and systemic side effects. The individual components of the acrylic materials may leave the dental restorations and diffuse into saliva. The aim of this study was to point out the potentially toxic components of acrylic dental materials, as well as their possible adverse effects on oral tissues and the organism in general. The paper was based on the assumption that the appropriate selection of the type of acrylic material and the proper method of their preparation reduce their adverse effects to a minimum, which was proven using literature data...
December 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29243777/mirna-338-3p-regulates-cervical-cancer-cells-proliferation-by-targeting-macc1-through-mapk-signaling-pathway
#9
F-F Hua, S-S Liu, L-H Zhu, Y-H Wang, X Liang, N Ma, H-R Shi
OBJECTIVE: Aberrant expression of miR-338-3p has recently involved in the progression and development of various types of malignant tumors, but its role in the progression of cervical cancer remains unknown. This study aims to investigate the role of miR-338-3p/MACC1 axis in the progression of cervical cancer. PATIENTS AND METHODS: MiR-338-3p and metastasis-associated in colon cancer 1 (MACC1) expression was determined in cervical cancer by quantitative real-time PCR (qRT-PCR)...
December 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29243539/the-influence-of-neighbor-effect-and-urbanization-toward-organ-donation-in-thailand
#10
Kua Wongboonsin, Pavitra Jindahra, Surat Teerakapibal
INTRODUCTION: Toward population wellness, an extreme scarcity of organ supply is proven to be an enormous hindrance. Preferences toward organ donation are vital to raise the organ donation rate. Notably, the area people live in can address the social influence on individual preference toward organ donation. RESEARCH QUESTIONS: This article studies the impact of the neighbor effect on organ donation decisions, addressing the social influence of urbanization on preferences...
January 1, 2017: Progress in Transplantation
https://www.readbyqxmd.com/read/29243455/intrathoracic-stomach-in-hiatal-hernia-the-role-of-laparoscopic-repair
#11
Petrus S Castelijns, Jeroen E Ponten, Nicole D Bouvy, Johannes F Smulders, Marcel C van de Poll
INTRODUCTION: For decades, intrathoracic stomach has been an indication for surgical repair and over time laparoscopy has become standard treatment. However, there are still many aspects in the treatment of intrathoracic stomach that subject of debate. We performed a literature review to discuss the role of laparoscopy in intrathoracic stomach repair. EVIDENCE ACQUISITION: We performed an extensive literature search in Pubmed, Embase and Cochrane and reviewed studies from the past 5 years...
December 14, 2017: Minerva Chirurgica
https://www.readbyqxmd.com/read/29242857/biphasic-drug-release-from-electrospun-polyblend-nanofibers-for-optimized-local-cancer-treatment
#12
Gaizhen Kuang, Zhiyun Zhang, Shi Liu, Dongfang Zhou, Xiaolan Lu, Xiabin Jing, Yubin Huang
The application of the biphasic release profile furnished by electrospun polyblend nanofibers for local cancer treatment was investigated. By adjusting the weight ratio of the hydrophilic polymer (poly(ethylene oxide), PEO) and hydrophobic polymer (poly(l-lactide), PLA), PEO10-PLA90 fibers with typical biphasic release kinetics were successfully prepared. Due to their unique release profile, PEO10-PLA90 fibers can quickly access the tumor site in vivo at a high drug content within 1 h and keep at a high level for longer than two weeks...
December 15, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29242158/additively-manufactured-biodegradable-porous-magnesium
#13
Y Li, J Zhou, P Pavanram, M A Leeflang, L I Fockaert, B Pouran, N Tümer, K-U Schröder, J M C Mol, H Weinans, H Jahr, A A Zadpoor
An ideal bone substituting material should be bone-mimicking in terms of mechanical properties, present a precisely controlled and fully interconnected porous structure, and degrade in the human body to allow for full regeneration of large bony defects. However, simultaneously satisfying all these three requirements has so far been highly challenging. Here we present topologically ordered porous magnesium (WE43) scaffolds based on the diamond unit cell that were fabricated by selective laser melting (SLM) and satisfy all the requirements...
December 11, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29242131/knowledge-translation-the-bridging-function-of-cochrane-rehabilitation
#14
Stefano Negrini, Francesca Gimigliano, Chiara Arienti, Carlotte Kiekens
Cochrane Rehabilitation is aimed to ensure that all rehabilitation professionals can apply Evidence Based Clinical Practice and take decisions according to the best and most appropriate evidence in this specific field, combining the best available evidence as gathered by high quality Cochrane systematic reviews, with their own clinical expertise and the values of patients. This mission can be pursued through Knowledge Translation. The aim of this paper is to shortly present what Knowledge Translation is, how and why Cochrane (previously known as Cochrane Collaboration) is trying to reorganize itself in light of Knowledge Translation, and the relevance that this process has for Cochrane Rehabilitation and in the end for the whole world of Rehabilitation...
December 11, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29241772/location-of-skin-lesions-in-henoch-sch%C3%A3-nlein-purpura-and-its-association-with-significant-renal-involvement
#15
Jessica St John, Priyanka Vedak, Anna Cristina Garza-Mayers, Mai P Hoang, Sagar U Nigwekar, Daniela Kroshinsky
BACKGROUND: Henoch-Schönlein purpura (HSP) is a small vessel IgA-predominant vasculitis. OBJECTIVE: To describe adult patients with HSP and determine if the distribution of skin lesions (ie, purpura above the waist or purpura below the waist only), is a predictor of significant renal involvement at the time of the skin biopsy and the months following. METHODS: A retrospective study on renal function from 72 adult patients with skin-biopsy proven HSP...
January 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29241729/long-term-follow-up-of-ipex-syndrome-patients-after-different-therapeutic-strategies-an-international-multicenter-retrospective-study
#16
Federica Barzaghi, Laura Cristina Amaya Hernandez, Benedicte Neven, Silvia Ricci, Zeynep Yesim Kucuk, Jack Bleesing, Zohreh Nademi, Mary Anne Slatter, Erlinda Rose Ulloa, Anna Shcherbina, Anna Roppelt, Austen Worth, Juliana Silva, Alessandro Aiuti, Luis Murguia-Favela, Carsten Speckmann, Magda Carneiro-Sampaio, Juliana Folloni Fernandes, Safa Baris, Ahmet Ozen, Elif Karakoc-Aydiner, Ayca Kiykim, Ansgar Schulz, Sandra Steinmann, Lucia Dora Notarangelo, Eleonora Gambineri, Paolo Lionetti, William Thomas Shearer, Lisa Forbes, Caridad Martinez, Despina Moshous, Stephane Blanche, Alain Fisher, Frank M Ruemmele, Come Tissandier, M Ouachee-Chardin, Frédéric Rieux-Laucat, Marina Cavazzana, Waseem Qasim, Barbarella Lucarelli, Michael H Albert, Ichiro Kobayashi, Laura Alonso, Cristina Diaz De Heredia, Hirokazu Kanegane, Anita Lawitschka, Jong Jin Seo, Marta Gonzalez-Vicent, Miguel Angel Diaz, Rakesh Kumar Goyal, Martin G Sauer, Akif Yesilipek, Minsoo Kim, Yesim Yilmaz-Demirdag, Monica Bhatia, Julie Khlevner, Erick J Richmond Padilla, Silvana Martino, Davide Montin, Olaf Neth, Agueda Molinos-Quintana, Justo Valverde-Fernandez, Arnon Broides, Vered Pinsk, Antje Ballauf, Filomeen Haerynck, Victoria Bordon, Catharina Dhooge, Maria Laura Garcia-Lloret, Robbert G Bredius, Krzysztof Kałwak, Elie Haddad, Markus Gerhard Seidel, Gregor Duckers, Sung-Yun Pai, Christopher C Dvorak, Stephan Ehl, Franco Locatelli, Frederick Goldman, Andrew Richard Gennery, Mort J Cowan, Maria Grazia Roncarolo, Rosa Bacchetta
BACKGROUND: Immunedysregulation Polyendocrinopathy Enteropathy X-linked (IPEX) syndrome is a monogenic autoimmune disease caused by FOXP3 mutations. Because it is a rare disease, the natural history and response to treatments, including allogeneic hematopoietic stem cell transplantation (HSCT) and immunosuppression (IS), have not been thoroughly examined. OBJECTIVE: To evaluate disease onset, progression and long-term outcome of the two main treatments in long-term IPEX survivors...
December 11, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29241725/value-of-water-enema-computed-tomography-in-elderly-symptomatic-patients
#17
Heyfa Romdhane, Imen Marzouk, Zeineb Mzoughi, Meriem Cheikh, Meriem Dridi, Houcem Fadhl, Rym Ennaifer, Najet Belhadj
BACKGROUND AND STUDY AIMS: Colonoscopy remains the gold standard for the examination of the colon. However, its use in the elderly is not well tolerated, and there is often a need for general anaesthesia, thus increasing the risk, especially if there are co-morbidities. Water enema computed tomography has been suggested to be a satisfactory alternative as a non-invasive, fast and effective means for the diagnosis of colorectal supra-centimetric lesions. The aim of our study was to assess the performance of water enema computed tomography as first-line examination by calculating its negative predictive value (NPV) for the diagnosis of supra-centimetric lesions in symptomatic elderly referred to colonoscopy...
December 11, 2017: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/29241706/placement-of-an-absorbable-rectal-hydrogel-spacer-in-patients-undergoing-low-dose-rate-brachytherapy-with-palladium-103
#18
Amandeep S Taggar, Tomer Charas, Gil'ad N Cohen, Keeratikarn Boonyawan, Marisa Kollmeier, Sean McBride, Nitin Mathur, Antonio L Damato, Michael J Zelefsky
PURPOSE: Rates of rectal toxicity after low-dose-rate (LDR) brachytherapy for prostate cancer are dependent on rectal dose, which is associated with rectal distance from prostate and implanted seeds. Placement of a hydrogel spacer between the prostate and rectum has proven to reduce the volume of the rectum exposed to higher radiation dose levels in the setting of external beam radiotherapy. We present our findings with placing a rectal hydrogel spacer in patients following LDR brachytherapy, and we further assess the impact of this placement on dosimetry and acute rectal toxicity...
December 11, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29241652/acute-administration-of-roflumilast-enhances-immediate-recall-of-verbal-word-memory-in-healthy-young-adults
#19
M A Van Duinen, A Sambeth, P R A Heckman, S Smit, M Tsai, G Lahu, T Uz, A Blokland, J Prickaerts
The need for new and effective treatments for dementia remains indisputably high. Phosphodiesterase inhibitors (PDE-Is) have proven efficacy as cognitive enhancers based on their positive effects in numerous preclinical studies. Especially the PDE4 subfamily is of interest due to its expression in the hippocampus, the key structure for memory formation. The current study investigates the memory enhancing effects of the clinically approved PDE4-I roflumilast in a test battery including the Verbal Learning Task (VLT) combined with electroencephalography (EEG) recording...
December 11, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29241489/hydroquinidine-prevents-life-threatening-arrhythmic-events-in-patients-with-short%C3%A2-qt%C3%A2-syndrome
#20
Andrea Mazzanti, Riccardo Maragna, Gaetano Vacanti, Anna Kostopoulou, Maira Marino, Nicola Monteforte, Raffaella Bloise, Katherine Underwood, Valentina Tibollo, Eleonora Pagan, Carlo Napolitano, Riccardo Bellazzi, Vincenzo Bagnardi, Silvia G Priori
BACKGROUND: Short QT syndrome (SQTS) is a rare and life-threatening arrhythmogenic syndrome characterized by abbreviated repolarization. Hydroquinidine (HQ) prolongs the QT interval in SQTS patients, although whether it reduces cardiac events is currently unknown. OBJECTIVES: This study investigated whether long-term treatment with HQ reduces the occurrence of life-threatening arrhythmic events (LAE) (cardiac arrest or sudden cardiac death) in SQTS patients. METHODS: In this cohort study on consecutive SQTS patients, 2 analyses were performed: 1) a matched-period analysis for the occurrence of LAE in 17 SQTS patients who received long-term HQ; and 2) a comparison of the annual incidence of LAE off- and on-HQ in 16 SQTS patients who survived a cardiac arrest...
December 19, 2017: Journal of the American College of Cardiology
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