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Aparna Komarraju, Twyla B Bartel, Lisa A Dickinson, Frederick D Grant, Tracy L Yarbrough
INTRODUCTION: Increasingly, emerging technologies are expanding instructional possibilities, with new methods being adopted to improve knowledge acquisition and retention. Within medical education, many new techniques have been employed in the undergraduate setting, with less utilization thus far in the continuing medical education (CME) sphere. This paper discusses the use of a new method for CME-the "flipped classroom," widely used in undergraduate medical education. This method engages learners by providing content before the live ("in class") session that aids in preparation and fosters in-class engagement...
June 21, 2018: Journal of Continuing Education in the Health Professions
Fusun Citak-Er, Zeynep Firat, Ilhami Kovanlikaya, Ugur Ture, Esin Ozturk-Isik
OBJECTIVE: The objective of this study was to assess the contribution of multi-parametric (mp) magnetic resonance imaging (MRI) quantitative features in the machine learning-based grading of gliomas with a multi-region-of-interests approach. MATERIALS AND METHODS: Forty-three patients who were newly diagnosed as having a glioma were included in this study. The patients were scanned prior to any therapy using a standard brain tumor magnetic resonance (MR) imaging protocol that included T1 and T2-weighted, diffusion-weighted, diffusion tensor, MR perfusion and MR spectroscopic imaging...
June 15, 2018: Computers in Biology and Medicine
Siba Narayan Bhujabal, Pratap Chandra Nath, Ranjit Behera, Pankaj Kumar Swarnakar, Manmath Kumar Dhir, Sanjib Mishra
BACKGROUND: Inflammatory pseudotumor is a histologically proven benign tumor like lesion of unknown etiopathogenesis. It is less commonly found in central nervous system and least common in spinal canal. Among them spinal epidural inflammatory pseudotumor is a rarely reported entity. CASE DESCRIPTION: We report here a case who presented with paraplegia having a spinal epidural mass which was diagnosed as inflammatory pseudotumor after surgical excision followed by histopathology...
June 19, 2018: World Neurosurgery
M Hasib Sidiqi, Mohammed A Aljama, Eli Muchtar, Francis K Buadi, Rahma Warsame, Martha Q Lacy, Angela Dispenzieri, David Dingli, Nelson Leung, Wilson I Gonsalves, Prashant Kapoor, Taxiarchis V Kourelis, William J Hogan, Shaji K Kumar, Morie A Gertz
Autologous stem cell transplantation has been used in treatment for AL amyloidosis for over two decades and generally reserved for patients younger than 70 years of age. Herein we report on outcomes of ASCT in a cohort of patients with AL amyloidosis aged 70 years or older. Between August of 2002 and April of 2017, 34 patients aged 70 years or older, with biopsy proven AL amyloidosis, received an autologous stem cell transplant at the Mayo Clinic Rochester. 70% (n=24) of patients were transplanted within 6 months of diagnosis and 74% (n=25) received reduced intensity conditioning with melphalan <200mg/m2...
June 19, 2018: Biology of Blood and Marrow Transplantation
Mr Edward Jeans, Mr Richard Holleyman, Dr David Tate, Mr Mike Reed, Mr Ajay Malviya
AIMS: Periprosthetic joint infection (PJI) is a catastrophic and potentially life threatening complication following arthroplasty. In addition to the resulting impact on patient morbidity and mortality, PJI is associated with significant financial cost, which is estimated at £21,937 per case. Methicillin sensitive staphylococcus aureus (MSSA) is a common isolate in PJI and colonisation is a proven risk factor for subsequent infection. The aims of this study were: 1) to determine if MSSA screening and decolonisation reduced MSSA PJI rate in primary joint replacement and 2) to determine cost effectiveness of such a screening program...
June 19, 2018: Journal of Infection
Claus G Roehrborn, Martin M Miner, Richard Sadovsky
In this review, we focus on current trends in the management of male lower urinary tract symptoms (LUTS), defined here as LUTS, namely, storage, voiding, and post-micturition symptoms presumed secondary to benign prostatic hyperplasia (BPH), and discuss possible novel approaches toward better care. According to results of a PubMed database search covering the last 10 years and using keywords pertaining to male LUTS, this condition continues to be globally undiagnosed or diagnosed late, partly because of men's hesitation to seek help for perceived embarrassing problems or problems considered a normal part of aging...
June 22, 2018: Postgraduate Medicine
Anniece Spencer, Nuzhat Majid, Gina M McCaskill, Loretta T Lee
Pre-diabetes is the underlying pathology for type 2 diabetes. The Diabetes Prevention Program is a proven, effective strategy to control or prevent type 2 diabetes; however, there is limited data on what motivates people with pre-diabetes to participate in a Diabetes Prevention Program. Cross-sectional analysis of survey data from adults with pre-diabetes was conducted from October to November 2015. Fisher's exact test was utilized to examine relationships between study variables. Findings indicated that muscle strength was related to commitment to healthy lifestyle behaviors (p = 0...
July 2017: Journal of National Black Nurses' Association: JNBNA
A Sprygin, Y Pestova, P Prutnikov, A Kononov
Since 2012, lumpy skin disease virus (LSDV) has been spreading from the Middle East to south-east Europe and Russia. Although vaccination campaigns have managed to contain LSDV outbreaks, the risk of further spread is still high. The most likely route of LSDV transmission in short distance spread is vector-borne. Several arthropod species have been suggested as potential vectors, but no proven vector has yet been identified. To check whether promiscuous-landing synanthropic flies such as the common housefly (Musca domestica) could be involved, we carried out entomological trapping at the site of a recent LSDV outbreak caused by a vaccine-like LSDV strain...
June 22, 2018: Transboundary and Emerging Diseases
Xiao Huang, Zheng Tang, Xiaomei Wu, Lihua Zhang, Wenjing Fan, Haitao Zhang, Weixin Hu, Zhihong Liu
AIMS: To investigate the renal pathological characteristics, renal outcomes and risk factors in lupus nephritis (LN) patients qualified as familial systemic lupus erythematosus (SLE). MATERIALS AND METHODS: Patients with biopsy-proven LN of familial SLE were enrolled. The clinical, laboratory, and pathological data of familial patients were analyzed and compared with those of sporadic SLE patients. The renal prognosis and risk factors were also assessed. RESULTS: 68 biopsy-proven familial SLE patients with LN were investigated...
June 22, 2018: Clinical Nephrology
Toshikazu D Tanaka, Mitsuaki Sawano, Ravi Ramani, Mark Friedman, Shun Kohsaka
Globally, acute heart failure (AHF) remains an ongoing public health issue with its prevalence and mortality increasing in the east and the west. Effective treatment strategies to stabilize AHF are important to alleviate clinical symptoms and to improve clinical outcomes. However, despite the progress in the management of stable and chronic heart failure, no single agent has been proven to play a definitive role in the management of AHF. As a consequence, contemporary treatment strategies for patients with AHF vary greatly by region...
June 22, 2018: ESC Heart Failure
C Sagnelli, C Uberti-Foppa, H Hasson, G Bellini, C Minichini, S Salpietro, E Messina, D Barbanotti, M Merli, F Punzo, N Coppola, A Lazzarin, E Sagnelli, F Rossi
OBJECTIVES: The aim of the study was to investigate whether the rs35761398 variants of the cannabinoid receptor 2 (CB2) gene may influence the acquisition of HIV infection and the clinical presentation of HIV/hepatitis C virus (HCV) coinfection. METHODS: We compared 166 HIV/HCV-coinfected patients with 186 HCV-monoinfected patients, all with biopsy-proven chronic hepatitis (using the Ishak scoring system), naïve for anti-HCV treatment and tested for the CB2 rs35761398 polymorphism (using the TaqMan assay)...
June 22, 2018: HIV Medicine
Jordan K Villa, Yichi Su, Lydia M Contreras, Ming C Hammond
In bacteria and archaea, small RNAs (sRNAs) regulate complex networks through antisense interactions with target mRNAs in trans, and riboswitches regulate gene expression in cis based on the ability to bind small-molecule ligands. Although our understanding and characterization of these two important regulatory RNA classes is far from complete, these RNA-based mechanisms have proven useful for a wide variety of synthetic biology applications. Besides classic and contemporary applications in the realm of metabolic engineering and orthogonal gene control, this review also covers newer applications of regulatory RNAs as biosensors, logic gates, and tools to determine RNA-RNA interactions...
May 2018: Microbiology Spectrum
William R Reid, Haina Sun, James J Becnel, Andrew G Clark, Jeffrey G Scott
BACKGROUND: Neonicotinoids are the largest class of insecticides and are used for control of house fly populations at animal production facilities throughout the world. There have been several reports of neonicotinoid resistance in house fly populations, but identification of the factors involved in resistance has proven challenging. The KS8S3 population of house flies is highly resistant to the neonicotinoid insecticide imidacloprid due to two factors: one on chromosome 3 and one on chromosome 4...
June 21, 2018: Pest Management Science
Ömrüm Aydin, Max Nieuwdorp, Victor Gerdes
PURPOSE OF REVIEW: The objective of this review is to critically assess the contributing role of the gut microbiota in human obesity and type 2 diabetes (T2D). RECENT FINDINGS: Experiments in animal and human studies have produced growing evidence for the causality of the gut microbiome in developing obesity and T2D. The introduction of high-throughput sequencing technologies has provided novel insight into the interpersonal differences in microbiome composition and function...
June 21, 2018: Current Diabetes Reports
Chung-Yuan Hsu, Yu-Sheng Lin, Tien-Tsai Cheng, Ya-Jhu Syu, Ming-Shyan Lin, Hsing-Fen Lin, Yu-Jih Su, Ying-Chou Chen, Jia-Feng Chen, Tien-Hsing Chen
Objectives: HCQ, which is known to decrease SLE activity, may have a protective effect on survival, but this has not been proven in Asia. This study aimed to determine whether HCQ treatment is associated with increased survival in patients with SLE. Methods: We designed this prospective SLE cohort study using data from the Taiwan National Health Insurance Research Database. The participants were divided into HCQ and control groups according to whether HCQ was prescribed during the first year after an SLE diagnosis...
June 20, 2018: Rheumatology
Yixuan Li, Jingxuan Wang, Fazheng Ren, Wei Zhang, Hao Zhang, Liang Zhao, Ming Zhang, Wei Cui, Xiaobin Wang, Huiyuan Guo
Background: Lactoferrin (LF), as a major functional protein in dairy products, is known to modulate bone anabolic effects. However, the underlying molecular mechanisms remain unclear; the receptor of LF in osteoblast differentiation has not been identified. Objective: The aims of the study were to 1) illuminate whether the receptor of LF in osteoblast differentiation is transforming growth factor-β (TGF-β) receptor (TβR) II and 2) determine whether the TGF-β signaling pathway is activated by LF in promoting osteogenesis in vitro and in vivo, in addition to P38 and extracellular signal-regulated kinase (ERK) pathways...
June 20, 2018: Journal of Nutrition
Sze Chuen Cesar Wong, Thomas Chi Chuen Au, Sammy Chung Sum Chan, Lawrence Po Wah Ng, Hin Fung Tsang
Background: Human papillomavirus (HPV) is a known causative factor in the etiology of cervical cancer. Methods: HPV DNA genotyping was performed in menstrual blood (MB) collected in napkins from patients with cervical intraepithelial neoplasia (CIN), HPV infection and sexually active apparently normal subjects. In the same patient cohort, MB TAP1 I333V and TAP1 D637G gene polymorphisms were examined. Results: The sensitivity, specificity, positive and negative predictive values of HPV DNA to detect CIN or HPV infection was 83% (223/268), 98% (131/134), 99% (223/226) and (74%) 131/176, respectively...
June 19, 2018: Journal of Infectious Diseases
Lucia Casali, Luca Mazzei, Oleksii Shemchuk, Kenneth Honer, Fabrizia Grepioni, Stefano Ciurli, Dario Braga, Jonas Baltrusaitis
A smart ionic co-crystal of urea with KCl and ZnCl2 has been obtained in two polymorphic modifications via mechanochemical and solution methods and proven to be a very efficient urease inhibitor while, simultaneously, able to provide soil nutrients to complement N supply.
June 22, 2018: Chemical Communications: Chem Comm
Anne Bauer, Astrid Jäschke, Sebastian Schöne, Robert Barthen, Juliane März, Katja Schmeide, Michael Patzschke, Berthold Kersting, Karim Fahmy, Jana Oertel, Vinzenz Brendler, Thorsten Stumpf
The environmental aspects of ore processing and waste treatment call for an optimization of applied technologies. There, understanding of the structure and complexation mechanism on a molecular scale is indispensable. Here, the complexation of UVI with a calix[4]arene-based 8-hydroxyquinoline ligand was investigated by applying a wide range of complementary methods. In solution, the formation of two complex species was proven with stability constants of log  ß 1:1 =5.94±0.02 and log  ß 2:1 =6.33±0.01, respectively...
June 2018: ChemistryOpen
James I Ausman, David S Liebeskind, Nestor Gonzalez, Jeffrey Saver, Neil Martin, J Pablo Villablanca, Paul Vespa, Gary Duckwiler, Reza Jahan, Tianyi Niu, Noriko Salamon, Bryan Yoo, Satoshi Tateshima, Manuel M Buitrago Blanco, Sidney Starkman
We have reviewed the English literature published in the last 70 years on Diseases of the Vertebral Basilar Circulation, or Posterior Circulation Disease (PCD). We have found that errors have been made in the conduct and interpretation of these studies that have led to incorrect approaches to the management of PCD. Because of the difficulty in evaluating the PC, the management of PCD has been incorrectly applied from anterior circulation disease (ACD) experience to PCD. PCD is a common form of stroke affecting 20-40% patients with stroke...
2018: Surgical Neurology International
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