Taha Yazal, Po-Yen Lee, Pin-Rong Chen, I-Chen Chen, Po-Len Liu, Yuan-Ru Chen, Tzu-Chieh Lin, Yi-Ting Chen, Shu-Pin Huang, Hsin-Chih Yeh, Ching-Chih Liu, Jung Lo, Hsin-En Wu, Shu-Chi Wang, Chia-Yang Li
Kurarinone, a major lavandulyl flavanone found in the roots of Sophora flavescens aiton, has been reported to exhibit anti-inflammatory and anti-oxidative activities in lipopolysaccharide (LPS)-induced macrophages; however, the effects of kurarinone on the activation of NLRP3 inflammasome and the protective effects against sepsis have not been well investigated. In this study, we aimed to investigate the impacts of kurarinone on NLRP3 inflammasome activation in lipopolysaccharide (LPS)-induced macrophages and its protective effects against sepsis in vivo...
October 5, 2023: Biomedicine & Pharmacotherapy