Lingling Song, Xiaohui Wu, Junming Wang, Yuechen Guan, Yueyue Zhang, Mingzhu Gong, Yanmei Wang, Bingyin Li
This study aimed to investigate the antidepressant effect and mechanism of catalpol in corticosterone (CORT)-induced depressive-like behavior in mice for the first time. As a result, CORT injection induced depressive-like behaviors of mice in behavioral tests, aggravated the serum CORT, adrenocorticotropic hormone, and corticotropin-releasing hormone levels, and conspicuously elevated the phosphorylations of NF-κB in the hippocampus and frontal cortex, and down-regulated the expression levels of Nrf2. Furthermore, CORT exposure dramatically augmented the levels of inflammatory factors (IL-1β, TNF-α, iNOS, NO) and lipid peroxidation product MDA, and attenuated the levels of antioxidants including GSH, GST, SOD, and HO-1 in the hippocampus and frontal cortex...
September 6, 2021: Brain Research Bulletin