Yanfang Zheng, Xian Zhou, Chenxiang Wang, Jialin Zhang, Dennis Chang, Shuting Zhuang, Wen Xu, Yong Chen, Xiaoning Wang, Lihong Nan, Yibin Sun, Xiaohui Lin, Wei Lin, Caigu He, Lian Dai, Jieping Zhang, Jianyu Chen, Hong Shi, Mingqing Huang
Dendrobium mixture (DM) is a patent Chinese herbal formulation consisting of Dendrobii Caulis, Astragali Radix, Rehmanniae Radix as the main ingredients. DM has been shown to alleviate diabetic related symptoms attributed to its anti-hyperglycaemic and anti-inflammatory activities. However, the effect on diabetic induced cognitive dysfunction has not been investigated. This study aims to investigate the effect of DM in improving diabetic cognitive impairment and associated mechanisms. Our study confirmed the anti-hyperglycaemic effect of DM and showed its capacity to restore the cognitive and memory function in high fat/high glucose and streptozotocin-induced diabetic rats...
May 2022: Biomedicine & Pharmacotherapy