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https://www.readbyqxmd.com/read/27830011/catalpol-ameliorates-diabetic-atherosclerosis-in-diabetic-rabbits
#1
Jiang-Yue Liu, Chen-Zhao Zheng, Xin-Ping Hao, Dai-Juan Zhang, An-Wei Mao, Ping Yuan
Catalpol, isolated from the roots of Rehmanniaglutinosa, Chinese foxglove, is an iridoid glycoside with antioxidant, anti-inflammatory and anti-hyperglycemic agent. The present study was to investigate the effects of catalpol on diabetic atherosclerosis in alloxan-induced diabetic rabbits. Diabetes was induced in rabbits by a hyperlipidemic diet and intravenous injection of alloxan (100 mg/kg). Rabbits were treated for 12 weeks. The fasting blood glucose, insulin, homeostasis model of insulin resistance, total cholesterol and triglyceride were measured...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27789455/catalpol-restores-lps-elicited-rat-microcirculation-disorder-by-regulation-of-a-network-of-signaling-involving-inhibition-of-tlr-4-and-src
#2
Yun-Pei Zhang, Chun-Shui Pan, Li Yan, Yu-Ying Liu, Bai-He Hu, Xin Chang, Quan Li, Dan-Dan Huang, Hao-Yu Sun, Ge Fu, Kai Sun, Jing-Yu Fan, Jing-Yan Han
Lipopolysaccharide (LPS)-induced microvascular hyperpermeability and hemorrhage play a key role in the development of sepsis, attenuation of which might be an important strategy to prevent sepsis. However, present clinical therapies are proved to be inefficiency in improving the final survival rate for the patients with sepsis. Catalpol, an iridoid glycoside extracted from the roots of Rehmannia, has been reported able to protect against LPS-induced acute lung injury through Tool-like Receptor-4 (TLR-4) mediated NF-κB signaling pathway...
October 27, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27659301/anti-ageing-active-ingredients-from-herbs-and-nutraceuticals-used-in-traditional-chinese-medicine-pharmacological-mechanisms-and-implications-for-drug-discovery
#3
REVIEW
Chun-Yan Shen, Jian-Guo Jiang, Li Yang, Da-Wei Wang, Wei Zhu
Ageing, an unanswered question in the medical field, is a multifactorial process that results in a progressive functional decline in cells, tissues and organisms. Although it is impossible to prevent ageing, slowing down the rate of ageing is entirely possible to achieve. Traditional Chinese medicine (TCM) is characterized by the nourishing of life and its role in anti-ageing is getting more and more attention. This article summarizes the work done on the natural products from TCM that are reported to have anti-ageing effects, in the past two decades...
September 23, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27459772/nectar-microbes-can-reduce-secondary-metabolites-in-nectar-and-alter-effects-on-nectar-consumption-by-pollinators
#4
Rachel L Vannette, Tadashi Fukami
Secondary metabolites that are present in floral nectar have been hypothesized to enhance specificity in plant-pollinator mutualism by reducing larceny by non-pollinators, including microorganisms that colonize nectar. However, few studies have tested this hypothesis. Using synthetic nectar, we conducted laboratory and field experiments to examine the effects of five chemical compounds found in nectar on the growth and metabolism of nectar-colonizing yeasts and bacteria, and the interactive effects of these compounds and nectar microbes on the consumption of nectar by pollinators...
June 2016: Ecology
https://www.readbyqxmd.com/read/27429834/simultaneous-determination-of-catalpol-aucubin-and-geniposidic-acid-in-different-developmental-stages-of-rehmannia-glutinosa-leaves-by-high-performance-liquid-chromatography
#5
Yanjie Wang, Dengqun Liao, Minjian Qin, Xian'en Li
Although R. glutinosa roots are currently the only organ source in clinics, its leaves are a potential supplement for the roots especially in extraction of some important bioactive compounds. Our early work found that the contents of catalpol and total iridoid glycosides varied among different developmental stages of R. glutinosa leaves. Aucubin and geniposidic acid, the abundant major bioactive compounds in Eucommia ulmoides and Gardenia jasminoides, respectively, were found present in R. glutinosa roots, however, and have not been analyzed in its leaves...
2016: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/27419098/prophylactic-administration-of-an-extract-from-plantaginis-semen-and-its-major-component-aucubin-inhibits-mechanical-allodynia-caused-by-paclitaxel-in-mice
#6
Tsugunobu Andoh, Mitsuru Kato, Ryo Kitamura, Shizuka Mizoguchi, Daisuke Uta, Kazufumi Toume, Katsuko Komatsu, Yasushi Kuraishi
The chemotherapeutic agent paclitaxel (PTX) causes peripheral neuropathy as a major dose-limiting side effect, and this peripheral neuropathy is difficult to control. Our previous report showed that prophylactic repetitive administration of goshajinkigan ( niú chē shèn qì wán), but not hachimijiogan ( bā wèi dì huáng wán), which lacks two of the constituents of goshajinkigan, inhibited PTX-induced mechanical allodynia in mice. Thus, the herbal medicines Plantaginis Semen ( chē qián zǐ) or Achyranthis Radix ( niú xī) may contribute to the inhibitory action of goshajinkigan on the exacerbation of PTX-induced mechanical allodynia [Andoh et al, J...
July 2016: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/27418367/exogenous-feeding-of-immediate-precursors-reveals-synergistic-effect-on-picroside-i-biosynthesis-in-shoot-cultures-of-picrorhiza-kurroa-royle-ex-benth
#7
Varun Kumar, Neha Sharma, Hemant Sood, Rajinder Singh Chauhan
In the current study, we asked how the supply of immediate biosynthetic precursors i.e. cinnamic acid (CA) and catalpol (CAT) influences the synthesis of picroside-I (P-I) in shoot cultures of P. kurroa. Our results revealed that only CA and CA+CAT stimulated P-I production with 1.6-fold and 4.2-fold, respectively at 2.5 mg/100 mL concentration treatment. Interestingly, feeding CA+CAT not only directed flux towards p-Coumaric acid (p-CA) production but also appeared to trigger the metabolic flux through both shikimate/phenylpropanoid and iridoid pathways by utilizing more of CA and CAT for P-I biosynthesis...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27301615/catalpol-stimulates-vegf-production-via-the-jak2-stat3-pathway-to-improve-angiogenesis-in-rats-stroke-model
#8
Wan Dong, Yang Xian, Wang Yuan, Zhu Huifeng, Wang Tao, Liu Zhiqiang, Feng Shan, Fu Ya, Wang Hongli, Wang Jinghuan, Qin Lei, Zou Li, Qi Hongyi
ETHNOBOTANICAL RELEVANCE: Catalpol is the main active component of the radix from Rehmannia glutinosa Libosch, which has pleiotropic protective effects in neurodegenerative diseases, ischemic stroke, metabolic disorders and others AIM: Catalpol has been shown to have neuroprotective, neurorepair, and angiogenesis effects following ischemic brain injury. However, its molecular mechanisms are still poorly understood. In previous studies, the JAK2/STAT3 signaling pathway was found to play a role in neuroprotection and angiogenesis...
September 15, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27175212/antidiabetic-and-antioxidant-effects-of-catalpol-extracted-from-rehmannia-glutinosa-di-huang-on-rat-diabetes-induced-by-streptozotocin-and-high-fat-high-sugar-feed
#9
Huifeng Zhu, Yuan Wang, Zhiqiang Liu, Jinghuan Wang, Dong Wan, Shan Feng, Xian Yang, Tao Wang
BACKGROUND: Diabetes, associated with hyperlipidemia and oxidative stress, would lead to an increased production of reactive oxygen species. Rehmannia glutinosa (Di Huang) is widely used to nourish yin, invigorate the kidney (shen), and treat xiao ke (a diabetes-like syndrome in Chinese medicine). This study aims to investigate the antidiabetic and antioxidant effects of catalpol from R. glutinosa on rat diabetes induced by streptozotocin (STZ) and high-fat, high-sugar feed. METHODS: Rats (eight rats in each group at least) were induced diabetes by an initial high-fat high-sugar feed for 3 weeks, followed by an intraperitoneal injection of STZ (30 mg/kg) for 3 days, and rats were fasted overnight before treatments...
2016: Chinese Medicine
https://www.readbyqxmd.com/read/27166426/catalpol-inhibits-apoptosis-in-hydrogen-peroxide-induced-cardiac-myocytes-through-a-mitochondrial-dependent-caspase-pathway
#10
Ling-Ai Hu, Yu-Kun Sun, Hong-Sheng Zhang, Jin-Guo Zhang, Jian Hu
Catalpol, an iridoid glucoside, has been reported to inhibit apoptosis of neuron and endothelial cells. In the present study, we investigated the mechanism of catalpol-mediated cardioprotection. The rat embryonic ventricular myocardial cell line (H9c2) cells were first incubated with catalpol, and then exposed to hydrogen peroxide (H2O2). The concentration of malondialdehyde (MDA) and the activity of superoxide dismutase (SOD) were all determined by using commercially available kits. Apoptotic cells were assessed by Hoechst 33258 and Annexin V-fluorescein isothiocyanate binding assay...
July 2016: Bioscience Reports
https://www.readbyqxmd.com/read/27145608/nectar-chemistry-mediates-the-behavior-of-parasitized-bees-consequences-for-plant-fitness
#11
Leif L Richardson, M Deane Bowers, Rebecca E Irwin
Plants produce an array of secondary metabolites that play important ecological roles as anti-herbivore and anti-pathogen defenses. Many herbivores experience physiological costs when they consume secondary metabolites, yet some also benefit, for example when these chemicals confer resistance to parasites and predators. Secondary metabolites are often present in nectar and pollen, which is paradoxical given that floral rewards are important in the attraction of mutualists rather than deterrence of antagonists...
February 2016: Ecology
https://www.readbyqxmd.com/read/27097417/-effect-on-quality-of-scrophulariae-radix-with-modern-drying-technology
#12
Hui-wei Li, Pei Liu, Da-wei Qian, Xue-jun Lu, Sheng Guo, Zhen-hua Zhu, Jin-ao Duan
Modern drying technology was used to explore suitable drying process to provide scientific basis for improving drying processing methods of Scrophulariae Radix. Controlled temperature and humidity drying, vacuum drying apparatus, microwave vacuum drying apparatus, short infrared drying device were used to gain samples for analyzing. The character appearance, concentration of main components and power consumption indicators were chosen for preliminary judging. Six major components, including iridoids and phenylpropanoids were analyzed by UPLC-MS/MS method...
November 2015: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/27019622/lyophilized-powder-of-catalpol-and-puerarin-protects-neurovascular-unit-from-stroke
#13
Qiang Xue, Yang Liu, Ran He, Sheng Yang, Jie Tong, Xu Li, Yi Chen, Xiaoyu Xu
Hunting for an effective medicine for brain stroke has been a medical task in neuroscience for decades. The present research showed that the lyophilized Powder of Catalpol and Puerarin (C-P) in all the tested doses (65.4 mg/kg, 32.7 mg/kg, 16.4 mg/kg) significantly reduced the neurological deficiency, infarct volume and apoptotic cells in ischemic/reperfusion (I/R) rats. It also promoted astrocyte processes and prolonged neuron axons in infarct area. Further, it decreased MDA, NO, NF-κB/p65, TNF-α, IL-1β and IL-6 and enhanced the EPOR and GAF-43...
2016: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/27007911/catalpol-reduces-the-production-of-inflammatory-mediators-via-ppar-%C3%AE-activation-in-human-intestinal-caco-2-cells
#14
Kyoung Sik Park
Catalpol, a major iridoid glycoside present in Rehmannia glutinosa, has been reported to show a variety of pharmacological properties. However, the molecular mechanism underlying the anti-inflammatory effect of catalpol in intestinal cells remains poorly understood. The present study was aimed at investigating the effects of catalpol on the production of inflammatory mediators and its underlying signaling pathways in human intestinal Caco-2 cells. Catalpol significantly inhibited IL-1β-induced mRNA synthesis and protein production of pro-inflammatory cytokines, including IL-6, IL-8, and MCP-1...
July 2016: Journal of Natural Medicines
https://www.readbyqxmd.com/read/26986757/amelioration-of-diabetic-mouse-nephropathy-by-catalpol-correlates-with-down-regulation-of-grb10-expression-and-activation-of-insulin-like-growth-factor-1-insulin-like-growth-factor-1-receptor-signaling
#15
Shasha Yang, Huacong Deng, Qunzhou Zhang, Jing Xie, Hui Zeng, Xiaolong Jin, Zixi Ling, Qiaoyun Shan, Momo Liu, Yuefei Ma, Juan Tang, Qianping Wei
Growth factor receptor-bound protein 10 (Grb10) is an adaptor protein that can negatively regulate the insulin-like growth factor 1 receptor (IGF-1R). The IGF1-1R pathway is critical for cell growth and apoptosis and has been implicated in kidney diseases; however, it is still unknown whether Grb10 expression is up-regulated and plays a role in diabetic nephropathy. Catalpol, a major active ingredient of a traditional Chinese medicine, Rehmannia, has been reported to possess anti-inflammatory and anti-aging activities and then used to treat diabetes...
2016: PloS One
https://www.readbyqxmd.com/read/26937211/anti-diabetic-activities-of-catalpol-in-db-db-mice
#16
Qinwen Bao, Xiaozhu Shen, Li Qian, Chen Gong, Maoxiao Nie, Yan Dong
The objective was to investigate the hypoglycemic action of catalpol in spontaneous diabetes db/db mice. 40 db/db mice were randomly divided into fi ve groups: model control gourp; db/db plus catalpol 40, 80, 120 mg/kg body wt. groups and db/db plus metformin 250 mg/kg group. Age-matched db/m mice were selected as normal control group. The mice were administered with corresponding drugs or solvent by gavage for 4 weeks. The oral glucose tolerance test was carried out at the end of 3(rd) week. After 4 weeks of treatment, the concentrations of fasting blood glucose (FBG), glycated serum protein (GSP), insulin (INS), triglyceride (TG), total cholesterol (TC) and adiponection (APN) in serum were detected...
March 2016: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/26807192/catalpol-induces-oligodendrocyte-precursor-cell-mediated-remyelination-in-vitro
#17
Chun-Xiao Yuan, Takho Chu, Li Liu, Hao-Wen Li, Ya-Jie Wang, An-Chen Guo, Yong-Ping Fan
In demyelinating diseases such as multiple sclerosis, one of the treatment strategies includes remyelination using oligodendrocyte precursor cells (OPC). Catalpol, the extract of radix rehmanniae, is neuroprotective. Using an OPC culture model, we showed that 10 μM catalpol promotes OPC proliferation, cell migration and differentiation into mature oligodendrocytes. The 10 μM catalpol displayed stronger effects on OPCs migration and oligodendrocyte differentiation. These results suggest that catalpol has a potential role in promoting remyelination in demyelinating diseases, and is of therapeutic interest...
2015: American Journal of Translational Research
https://www.readbyqxmd.com/read/26741989/biotransformation-and-metabolic-profile-of-catalpol-with-human-intestinal-microflora-by-ultra-performance-liquid-chromatography-coupled-with-quadrupole-time-of-flight-mass-spectrometry
#18
Jin-hua Tao, Min Zhao, Dong-geng Wang, Chi Yang, Le-Yue Du, Wen-qian Qiu, Shu Jiang
Traditional Chinese medicine (TCM) has been used in clinical practice for thousands of years. Catalpol, an iridoid glucoside, abundantly found in the root of the common used herb medicine Rehmannia glutinosa Libosch, has been reported to show various biological effects and pharmacological activities. After oral administration, the active ingredient might have interactions with the intestinal bacteria, which could help unravel how the medicine was processed in vivo. In this work, different pure bacteria from healthy human feces were isolated and used to bioconvert catalpol...
January 15, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/26720701/simultaneous-determination-of-loganin-morroniside-catalpol-and-acteoside-in-normal-and-chronic-kidney-disease-rat-plasma-by-uplc-ms-for-investigating-the-pharmacokinetics-of-rehmannia-glutinosa-and-cornus-officinalis-sieb-drug-pair-extract
#19
Min Zhao, Jinhua Tao, Dawei Qian, Pei Liu, Er-xin Shang, Shu Jiang, Jianming Guo, Shu-lan Su, Jin-ao Duan, Leyue Du
A sensitive and rapid method for determination of loganin, morroniside, catalpol and acteoside in rat plasma after oral administration of Rehmannia glutinosa Libosch and Cornus officinalis Sieb drug pair based on ultra-high performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS). Chromatographic separation was achieved using an Acquity UPLC BEH C18 column (100mm×2.1mm, 1.7μm) at a flow rate of 0.4mL/min, using gradient mode containing 0.1% formic acid in water and acetonitrile were used as the mobile phase A and B...
January 15, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/26552915/effects-of-the-timing-of-herbivory-on-plant-defense-induction-and-insect-performance-in-ribwort-plantain-plantago-lanceolata-l-depend-on-plant-mycorrhizal-status
#20
Minggang Wang, T Martijn Bezemer, Wim H van der Putten, Arjen Biere
Plants often are exposed to antagonistic and symbiotic organisms both aboveground and belowground. Interactions between above- and belowground organisms may occur either simultaneously or sequentially, and jointly can determine plant responses to future enemies. However, little is known about time-dependency of such aboveground-belowground interactions. We examined how the timing of a 24 h period of aboveground herbivory by Spodoptera exigua (1-8 d prior to later arriving conspecifics) influenced the response of Plantago lanceolata and the performance of later arriving conspecifics...
November 2015: Journal of Chemical Ecology
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