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https://www.readbyqxmd.com/read/28545449/quantifying-the-global-contribution-of-alcohol-consumption-to-cardiomyopathy
#1
Jakob Manthey, Sameer Imtiaz, Maria Neufeld, Margaret Rylett, Jürgen Rehm
BACKGROUND: The global impact of alcohol consumption on deaths due to cardiomyopathy (CM) has not been quantified to date, even though CM contains a subcategory for alcoholic CM with an effect of heavy drinking over time as the postulated underlying causal mechanism. In this feasibility study, a model to estimate the alcohol-attributable fraction (AAF) of CM deaths based on alcohol exposure measures is proposed. METHODS: A two-step model was developed based on aggregate-level data from 95 countries, including the most populous (data from 2013 or last available year)...
May 25, 2017: Population Health Metrics
https://www.readbyqxmd.com/read/28540026/meta-analysis-of-gwas-of-over-16-000-individuals-with-autism-spectrum-disorder-highlights-a-novel-locus-at-10q24-32-and-a-significant-overlap-with-schizophrenia
#2
(no author information available yet)
BACKGROUND: Over the past decade genome-wide association studies (GWAS) have been applied to aid in the understanding of the biology of traits. The success of this approach is governed by the underlying effect sizes carried by the true risk variants and the corresponding statistical power to observe such effects given the study design and sample size under investigation. Previous ASD GWAS have identified genome-wide significant (GWS) risk loci; however, these studies were of only of low statistical power to identify GWS loci at the lower effect sizes (odds ratio (OR) <1...
2017: Molecular Autism
https://www.readbyqxmd.com/read/28521848/impacts-of-stocking-density-on-development-and-puberty-attainment-of-replacement-beef-heifers
#3
K M Schubach, R F Cooke, A P Brandão, K D Lippolis, L G T Silva, R S Marques, D W Bohnert
In all, 60 Angus×Hereford heifers were ranked by age and BW (210±2 days and 220±2 kg) on day 0, and assigned to: (a) one of three drylot pens (10×14 m pens; 10 heifers/pen) resulting in a stocking density of 14 m2/heifer (HIDENS; n=3), or (b) one of three pastures (25 ha pastures; 10 heifers/pasture), resulting in a stocking density of 25 000 m2/heifer (LOWDENS; n=3). Pastures were harvested for hay before the beginning of this experiment, and negligible forage was available for grazing to LOWDENS heifers during the experiment (days 0 to 182)...
May 19, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28520922/gc-ms-method-for-quantification-of-mephedrone-in-human-blood-sample
#4
Khaled M Mohamed
Abuse of mephedrone (4-methylmethcathinone) has emerged among the last few years. Intoxication and fatality associated with mephedrone have been reported in the literature. The present work describes a simple and rapid gas chromatography-mass spectrometry (GC-MS) method for detection and quantification of mephedrone in human blood samples using GC-MS. Blood was deproteinated with acetonitrile and the supernatant was derivatized and extracted in a single step with ethyl chloroformate and ethyl acetate. Methamphetamine-d5 was used as an internal standard (IS)...
May 18, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28520805/identification-of-key-contributors-in-complex-population-structures
#5
Markus Neuditschko, Herman W Raadsma, Mehar S Khatkar, Elisabeth Jonas, Eike J Steinig, Christine Flury, Heidi Signer-Hasler, Mirjam Frischknecht, Ruedi von Niederhäusern, Tosso Leeb, Stefan Rieder
Evaluating the genetic contribution of individuals to population structure is essential to select informative individuals for genome sequencing, genotype imputation and to ascertain complex population structures. Existing methods for the selection of informative individuals for genomic imputation solely focus on the identification of key ancestors, which can lead to a loss of phasing accuracy of the reference population. Currently many methods are independently applied to investigate complex population structures...
2017: PloS One
https://www.readbyqxmd.com/read/28520780/towards-a-point-of-care-strip-test-to-diagnose-sickle-cell-anemia
#6
Meaghan Bond, Brady Hunt, Bailey Flynn, Petri Huhtinen, Russell Ware, Rebecca Richards-Kortum
A rapid test to identify patients with sickle cell disease could have important benefits in low-resource settings. Sickle cell anemia (SCA) affects about 300,000 newborns each year, the majority of whom are born in sub-Saharan Africa. Low-cost therapies are available to treat SCA, but most countries in sub-Saharan Africa lack robust neonatal screening programs needed to identify patients in need of treatment. To address this need, we developed and evaluated a competitive lateral flow assay that identifies patients with SCA (genotype HbSS) in 15 minutes using undiluted whole blood...
2017: PloS One
https://www.readbyqxmd.com/read/28512111/an-initial-evaluation-of-the-impact-of-pok%C3%A3-mon-go-on-physical-activity
#7
Ying Xian, Hanzhang Xu, Haolin Xu, Li Liang, Adrian F Hernandez, Tracy Y Wang, Eric D Peterson
BACKGROUND: Pokémon GO is a location-based augmented reality game. Using GPS and the camera on a smartphone, the game requires players to travel in real world to capture animated creatures, called Pokémon. We examined the impact of Pokémon GO on physical activity (PA). METHODS AND RESULTS: A pre-post observational study of 167 Pokémon GO players who were self-enrolled through recruitment flyers or online social media was performed. Participants were instructed to provide screenshots of their step counts recorded by the iPhone Health app between June 15 and July 31, 2016, which was 3 weeks before and 3 weeks after the Pokémon GO release date...
May 16, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28508994/disease-modifying-effects-of-neural-regeneration-peptide-2945-in-the-gaers-model-of-absence-epilepsy
#8
Gabi Dezsi, Frank Sieg, Mark Thomas, Terence J O'Brien, Marieke van der Hart, Nigel C Jones
Epilepsy is a common neurological condition characterised by spontaneous recurrent seizures. Current anti-epileptic drugs are only effective and tolerated in ~70% of patients, leaving a substantial proportion of patients untreated. As such, there is a pressing need to develop new therapies. We assessed the anti-seizure activity of Neural Regeneration Peptide 2945 (NRP 2945) in the GAERS model of absence epilepsy. Drug effects on seizures were assessed using two study designs. Male adult GAERS were implanted with EEG electrodes to measure seizure frequency...
May 16, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28508482/solving-efficiently-large-single-step-genomic-best-linear-unbiased-prediction-models
#9
I Strandén, K Matilainen, G P Aamand, E A Mäntysaari
Single-step genomic BLUP (ssGBLUP) requires a dense matrix of the size equal to the number of genotyped animals in the coefficient matrix of mixed model equations (MME). When the number of genotyped animals is high, solving time of MME will be dominated by this matrix. The matrix is the difference of two inverse relationship matrices: genomic (G) and pedigree (A22 ). Different approaches were used to ease computations, reduce computing time and improve numerical stability. Inverse of A22 can be computed as A22-1=A22-A21A11-1A12 where A(ij) , i, j = 1,2, are sparse sub-matrices of A(-1) , and numbers 1 and 2 refer to non-genotyped and genotyped animals, respectively...
June 2017: Journal of Animal Breeding and Genetics, Zeitschrift Für Tierzüchtung und Züchtungsbiologie
https://www.readbyqxmd.com/read/28508425/bimetallic-nickel-substituted-cobalt-borate-nanowire-array-an-earth-abundant-water-oxidation-electrocatalyst-with-superior-activity-and-durability-at-near-neutral-ph
#10
Min Ma, Fengli Qu, Xuqiang Ji, Danni Liu, Shuai Hao, Gu Du, Abdullah M Asiri, Yadong Yao, Liang Chen, Xuping Sun
There is an urgent demand to develop earth-abundant electrocatalysts for efficient and durable water oxidation under mild conditions. A nickel-substituted cobalt-borate nanowire array is developed on carbon cloth (Ni-Co-Bi/CC) via oxidative polarization of NiCo2 S4 nanoarray in potassium borate (K-Bi). As a bimetallic electrocatalyst for water oxidation, such Ni-Co-Bi/CC is superior in catalytic activity and durability in 0.1 m K-Bi (pH: 9.2), with a turnover frequency of 0.33 mol O2 s(-1) at the overpotential of 500 mV and nearly 100% Faradaic efficiency...
May 16, 2017: Small
https://www.readbyqxmd.com/read/28501996/application-of-hydrogel-nanoparticles-for-the-capture-concentration-and-preservation-of-low-abundance-biomarkers
#11
Ruben Magni, Alessandra Luchini
In the recent years, a lot of emphasis has been placed on the discovery and detection of clinically relevant biomarkers. Biomarkers are crucial for the early detection of several diseases, and they play an important role in the improvement of current treatments, thus reducing patient mortality rate. Because biofluids account to 60% of the body mass, they represent a goldmine of significant biomarkers. Unfortunately, because of their low concentration in body fluids, their lability, and the presence of high abundance proteins (i...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28495848/physical-activity-modulates-corticospinal-excitability-of-the-lower-limb-in-young-and-old-adults
#12
Hamidollah Hassanlouei, Christopher W Sundberg, Ashleigh Elizabeth Smith, Andrew Kuplic, Sandra K Hunter
Aging is associated with reduced neuromuscular function, which may be due in part to altered corticospinal excitability. Regular physical activity (PA) may ameliorate these age-related declines, but the influence of PA on corticospinal excitability is unknown. The purpose of this study was to determine the influence of age, sex and PA on corticospinal excitability by comparing the stimulus-response curves of motor evoked potentials (MEP) in 28 young (22.4±2.2 yrs, 14 women, 14 men) and 50 old adults (70.2±6...
May 11, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28493314/use-of-lc-hrms-in-full-scan-xic-mode-for-multi-analyte-urine-drug-testing-a-step-towards-a-black-box-solution
#13
Niclas Nikolai Stephanson, Patrick Signell, Anders Helander, Olof Beck
The influx of new psychoactive substances (NPS) has created a need for improved methods for drug testing in toxicology laboratories. The aim of this work was to design, validate and apply a multi-analyte liquid chromatography-high resolution mass spectrometry (LC-HRMS) method for screening of 148 target analytes belonging to the NPS class, plant alkaloids and new psychoactive therapeutic drugs. The analytical method used a five-fold dilution of urine with 9 deuterated internal standards and injection of 2 μL...
May 10, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28492532/sherloc-a-comprehensive-refinement-of-the-acmg-amp-variant-classification-criteria
#14
Keith Nykamp, Michael Anderson, Martin Powers, John Garcia, Blanca Herrera, Yuan-Yuan Ho, Yuya Kobayashi, Nila Patil, Janita Thusberg, Marjorie Westbrook, Scott Topper
PurposeThe 2015 American College of Medical Genetics and Genomics-Association for Molecular Pathology (ACMG-AMP) guidelines were a major step toward establishing a common framework for variant classification. In practice, however, several aspects of the guidelines lack specificity, are subject to varied interpretations, or fail to capture relevant aspects of clinical molecular genetics. A simple implementation of the guidelines in their current form is insufficient for consistent and comprehensive variant classification...
May 11, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28480689/habitually-increasing-physical-activity-in-daily-life-during-8-week-intervention-reduces-arterial-stiffness-in-older-women-a-community-based-pilot-study
#15
Masato Nishiwaki, Mami Fujibayashi, Chika Nanayama, Noriko Ogawa, Isako Itakura, Naoyuki Matsumoto
BACKGROUND: The recent Japanese official physical activity (PA) guidelines for health promotion recommend increasing PA by 10 minutes per day (Plus 10), which generally corresponds to about 1,000 steps per day. However, whether habitually increasing PA in daily life improves arterial stiffness in older people is unclear. The present study aimed to examine the effects of habitually increasing PA during an intervention on arterial stiffness in older women. METHODS: Twenty-one older women (age, 76 ± 1 years) participated in supervised group activity and seated exercise for 60 min per session, once each week during an 8-week intervention...
May 5, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28479955/the-accuracy-of-pedometers-in-measuring-walking-steps-on-a-treadmill-in-college-students
#16
Hannah M Husted, Tamra L Llewellyn
Pedometers are a popular way for people to track if they have reached the recommended 10,000 daily steps. Therefore, the purpose of this study was to determine the accuracy of four brands of pedometers at measuring steps, and to determine if a relationship exists between pedometer cost and accuracy. The hypothesis was that the more expensive brands of pedometers (the Fitbit Charge™ and Omron HJ-303™) would yield more accurate step counts than less expensive brands (the SmartHealth - Walking FIT™ and Sportline™)...
2017: International Journal of Exercise Science
https://www.readbyqxmd.com/read/28479305/increasing-human-neural-stem-cell-transplantation-dose-alters-oligodendroglial-and-neuronal-differentiation-after-spinal-cord-injury
#17
Katja M Piltti, Gabriella M Funes, Sabrina N Avakian, Ara A Salibian, Kevin I Huang, Krystal Carta, Noriko Kamei, Lisa A Flanagan, Edwin S Monuki, Nobuko Uchida, Brian J Cummings, Aileen J Anderson
Multipotent human central nervous system-derived neural stem cells transplanted at doses ranging from 10,000 (low) to 500,000 (very high) cells differentiated predominantly into the oligodendroglial lineage. However, while the number of engrafted cells increased linearly in relationship to increasing dose, the proportion of oligodendrocytic cells declined. Increasing dose resulted in a plateau of engraftment, enhanced neuronal differentiation, and increased distal migration caudal to the transplantation sites...
May 3, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28476355/status-of-trauma-quality-improvement-programs-in-the-andean-region-what-foundation-do-we-have-to-build-on
#18
Lacey N LaGrone, Diego A Romaní Pozo, Juan F Figueroa, Maria A Artunduaga, Eduardo Huaman Egoavil, Manuel J A Rodriguez Castro, Jorge Esteban Foianini, Andrés M Rubiano, Edgar B Rodas, Charles N Mock
INTRODUCTION: Trauma quality improvement (QI) programs have been shown to improve outcomes and decrease cost. These are high priorities in low- and middle-income countries (LMICs), where 2,000,000 deaths due to survivable injuries occur each year. We sought to define areas for improvement in trauma QI programs in four LMICs. METHODS: We conducted a survey among trauma care providers in four Andean middle-income countries: Bolivia, Colombia, Ecuador, and Peru. RESULTS: 336 physicians, medical students, nurses, administrators and paramedical professionals responded to the cross-sectional survey with a response rate greater than 90% in all included countries except Bolivia, where the response rate was 14%...
April 7, 2017: Injury
https://www.readbyqxmd.com/read/28471613/rare-diseases-in-europe-from-a-wide-to-a-local-perspective
#19
REVIEW
Simone Baldovino, Antoni Montserrat Moliner, Domenica Taruscio, Erica Daina, Dario Roccatello
The European Union defines rare diseases (RDs) as life-threatening or chronically debilitating conditions whose prevalence is less than 5 per 10,000. Moreover, for many RDs, including those of genetic origin, combined efforts are required to reduce morbidity or perinatal or early mortality, and address the considerable decline in an individual's quality of life and socioeconomic potential. Their specificities, i.e., a limited number of patients and scarcity of relevant knowledge and expertise, make RDs a unique condition which requires wide cooperation at a supranational level...
June 2016: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28462361/estimation-of-anisotropic-permeability-in-trabecular-bone-based-on-microct-imaging-and-pore-scale-fluid-dynamics-simulations
#20
C Daish, R Blanchard, K Gulati, D Losic, D Findlay, D J E Harvie, P Pivonka
In this paper, a comprehensive framework is proposed to estimate the anisotropic permeability matrix in trabecular bone specimens based on micro-computed tomography (microCT) imaging combined with pore-scale fluid dynamics simulations. Two essential steps in the proposed methodology are the selection of (i) a representative volume element (RVE) for calculation of trabecular bone permeability and (ii) a converged mesh for accurate calculation of pore fluid flow properties. Accurate estimates of trabecular bone porosities are obtained using a microCT image resolution of approximately 10 μm...
June 2017: Bone Reports
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