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https://www.readbyqxmd.com/read/27901019/additives-for-vaccine-storage-to-improve-thermal-stability-of-adenoviruses-from-hours-to-months
#1
Maria Pelliccia, Patrizia Andreozzi, Jayson Paulose, Marco D'Alicarnasso, Valeria Cagno, Manuela Donalisio, Andrea Civra, Rebecca M Broeckel, Nicole Haese, Paulo Jacob Silva, Randy P Carney, Varpu Marjomäki, Daniel N Streblow, David Lembo, Francesco Stellacci, Vincenzo Vitelli, Silke Krol
Up to 80% of the cost of vaccination programmes is due to the cold chain problem (that is, keeping vaccines cold). Inexpensive, biocompatible additives to slow down the degradation of virus particles would address the problem. Here we propose and characterize additives that, already at very low concentrations, improve the storage time of adenovirus type 5. Anionic gold nanoparticles (10(-8)-10(-6) M) or polyethylene glycol (PEG, molecular weight ∼8,000 Da, 10(-7)-10(-4) M) increase the half-life of a green fluorescent protein expressing adenovirus from ∼48 h to 21 days at 37 °C (from 7 to >30 days at room temperature)...
November 30, 2016: Nature Communications
https://www.readbyqxmd.com/read/27892840/adhesive-cementation-promotes-higher-fatigue-resistance-to-zirconia-crowns
#2
F Campos, L F Valandro, S A Feitosa, C J Kleverlaan, A J Feilzer, N de Jager, M A Bottino
OBJECTIVE: The aim of this study was to investigate the influence of the cementation strategy on the fatigue resistance of zirconia crowns. The null hypothesis was that the cementation strategy would not affect the fatigue resistance of the crowns. METHODS AND MATERIALS: Seventy-five simplified molar tooth crown preparations were machined in glass fiber-filled epoxy resin. Zirconia crowns were designed (thickness=0.7 mm), milled by computer-aided design/computer-aided manufacturing, and sintered, as recommended...
November 28, 2016: Operative Dentistry
https://www.readbyqxmd.com/read/27878347/detection-and-diversity-of-the-nitrite-oxidoreductase-alpha-subunit-nxra-gene-of-nitrospina-in-marine-sediments
#3
Sundas Rani, Hyeon-Woo Koh, Sung-Keun Rhee, Hirotsugu Fujitani, Soo-Je Park
Nitrite-oxidizing bacteria (NOB) are chemolithoautotrophs that catalyze the oxidation of nitrite to nitrate, which is the second step of aerobic nitrification. In marine ecosystems, Nitrospina is assumed to be a major contributor to nitrification. To date, two strains of Nitrospina have been isolated from marine environments. Despite their ecological relevance, their ecophysiology and environmental distribution are understudied owing to fastidious cultivation techniques and the lack of a sufficient functional gene marker...
November 22, 2016: Microbial Ecology
https://www.readbyqxmd.com/read/27875528/effectiveness-of-seasonal-malaria-chemoprevention-in-children-under-ten-years-of-age-in-senegal-a-stepped-wedge-cluster-randomised-trial
#4
Badara Cissé, El Hadj Ba, Cheikh Sokhna, Jean Louis NDiaye, Jules F Gomis, Yankhoba Dial, Catherine Pitt, Mouhamed NDiaye, Matthew Cairns, Ernest Faye, Magatte NDiaye, Aminata Lo, Roger Tine, Sylvain Faye, Babacar Faye, Ousmane Sy, Lansana Konate, Ekoue Kouevijdin, Clare Flach, Ousmane Faye, Jean-Francois Trape, Colin Sutherland, Fatou Ba Fall, Pape M Thior, Oumar K Faye, Brian Greenwood, Oumar Gaye, Paul Milligan
BACKGROUND: Seasonal Malaria Chemoprevention (SMC) with sulfadoxine-pyrimethamine (SP) plus amodiaquine (AQ), given each month during the transmission season, is recommended for children living in areas of the Sahel where malaria transmission is highly seasonal. The recommendation for SMC is currently limited to children under five years of age, but, in many areas of seasonal transmission, the burden in older children may justify extending this age limit. This study was done to determine the effectiveness of SMC in Senegalese children up to ten years of age...
November 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27875500/activity-levels-over-four-years-in-a-cohort-of-urban-dwelling-adolescent-females
#5
Bonny Rockette-Wagner, Alison E Hipwell, Andrea M Kriska, Kristi L Storti, Kathleen M McTigue
PURPOSE: Evidence suggests that female adolescents and those living in urban environments may have lower physical activity (PA) levels compared to their peers. Yet, few studies report PA for urban adolescent females and there is no consensus regarding potential causes for low PA in this subgroup. We examined PA levels, in a large, diverse cohort of 14-17 year old urban-dwelling females and assessed the impact of socio-economic, personal, and neighborhood/environmental factors on PA. METHODS: One week of time-stamped step count data was collected on 926 girls from the Pittsburgh Girls Study (PGS) at four annual visits...
November 21, 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27870913/genomic-contributors-to-rhythm-outcome-of-atrial-fibrillation-catheter-ablation-pathway-enrichment-analysis-of-gwas-data
#6
Daniela Husser, Petra Büttner, Laura Ueberham, Borislav Dinov, Philipp Sommer, Arash Arya, Gerhard Hindricks, Andreas Bollmann
BACKGROUND: Left atrial enlargement and persistent atrial fibrillation (AF) are well-known predictors for arrhythmia recurrence after AF catheter ablation (LRAF). In this study, by using pathway enrichment analysis of GWAS data, we tested the hypothesis that genetic pathways associated with these phenotypes are also associated with LRAF. METHODS: Samples from 660 patients with paroxysmal (n = 370) or persistent AF (n = 290) undergoing de-novo AF catheter ablation were genotyped for ~1,000,000 SNPs...
2016: PloS One
https://www.readbyqxmd.com/read/27859976/fatigue-failure-of-narrow-implants-with-different-implant-abutment-connection-designs
#7
Dimorvan Bordin, Lukasz Witek, Vinícius P Fardin, Estevam A Bonfante, Paulo G Coelho
PURPOSE: To evaluate the reliability of narrow diameter dental implants (NDIs) with similar macrogeometry and 3 implant-abutment connection designs. MATERIALS AND METHODS: Eighty-four NDIs (3.5 × 10 mm) were selected and divided into 4 groups (n = 21/group) according to implant-abutment connection design, as follows: EH - external hexagon, IH - internal hexagon, IC - internal conical, and IC-M - internal conical connected to a monolithic titanium abutment. Identical abutments were torqued to the implants, and standardized maxillary incisor crowns were cemented and subjected to step-stress accelerated life testing (SSALT) in water...
November 18, 2016: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/27844139/-cardiovascular-prevention-and-regular-physical-exercise-activity-and-training-as-the-true-polypill
#8
H Löllgen, N Bachl
Guidelines for cardiovascular prevention need to be regularly revised and updated. With respect to physical activity and exercise, many studies with practical relevance have been published in recent years. They are concerned with the evidence of physical activity for prevention of many diseases and the spectrum of indications for applying physical activity for prevention, therapy and rehabilitation. Training recommendations have been developed for the prevention of various diseases according to the FITT rule, which stands for frequency, intensity, time (of session) and type of sports followed by a progression in the amount of training...
December 2016: Herz
https://www.readbyqxmd.com/read/27825317/epidemiology-and-outcome-of%C3%A2-clostridium-difficile%C3%A2-infections-in-patients-hospitalized-in-internal-medicine-%C3%A2-findings-from-the-nationwide-fadoi-practice-study
#9
Giorgio Cioni, Pierluigi Viale, Stefania Frasson, Francesco Cipollini, Francesco Menichetti, Nicola Petrosillo, Sergio Brunati, Patrizia Spigaglia, Chiara Vismara, Alessandra Bielli, Fabrizio Barbanti, Giancarlo Landini, Grazia Panigada, Gualberto Gussoni, Erminio Bonizzoni, Giovanni Pietro Gesu
BACKGROUND: Clostridium difficile (CD) is a leading cause of diarrhoea among hospitalized patients. The objective of this study was to evaluate the rate, the optimal diagnostic work-up, and outcome of CD infections (CDI) in Internal Medicine (IM) wards in Italy. METHODS: PRACTICE is an observational prospective study, involving 40 IM Units and evaluating all consecutive patients hospitalized during a 4-month period. CDI were defined in case of diarrhoea when both enzyme immunoassay for GDH, and test for A/B toxin were positive...
November 8, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27807795/can-we-shorten-the-q-space-imaging-to-make-it-clinically-feasible
#10
Koji Sakai, Kei Yamada, Kentaro Akazawa, Jun Tazoe, Masashi Yasuike, Hitomi Nagano, Hiroyasu Ikeno, Toshiaki Nakagawa
PURPOSE: Q-space imaging (QSI) is a novel magnetic resonance imaging (MRI) technique that enables assessment of micro-structural changes of white matter. The acquisition time, however, is comparatively long to use for routine clinical assessment. Therefore, the present study investigated the clinically feasible b value combinations to measure the water molecular displacement probability density function (PDF) in healthy subjects. METHODS: The subjects consisted of five healthy volunteers (1 female and 4 male; 40...
November 2, 2016: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/27797982/does-subjective-sleep-quality-improve-by-a-walking-intervention-a-real-world-study-in-a-japanese-workplace
#11
Hikaru Hori, Atsuko Ikenouchi-Sugita, Reiji Yoshimura, Jun Nakamura
OBJECTIVES: The purpose of this study was to evaluate the impact of a 4-week walking intervention on subjective sleep quality. DESIGN: A prospective open-label study. PARTICIPANTS: A total of 490 healthy workers were included in the study. The 490 participants were divided into a group of 214 participants with exercise habits (exercising group, EG) and a group of 276 participants without exercise habits (non-EG). INTERVENTIONS: A walking intervention with a target of walking 10 000 steps daily for 4 weeks...
October 24, 2016: BMJ Open
https://www.readbyqxmd.com/read/27783062/is-pedometer-determined-physical-activity-decreasing-in-czech-adults-findings-from-2008-to-2013
#12
Jana Pelclová, Karel Frömel, Emil Řepka, Ladislav Bláha, Aleš Suchomel, Igor Fojtík, Dana Feltlová, Petr Valach, Svatopluk Horák, Jiří Nykodým, Michal Vorlíček
Objective measured trend data are important for public health practice. However, these data are rare for an adult population. Therefore, the aim of this study was to describe time trends in pedometer-determined physical activity of Czech adults (25-65 years) from 2008 to 2013. Participants were Czech national citizens whose physical activity was assessed objectively using a Yamax Digiwalker SW-700 pedometer (Yamax Corporation, Tokyo, Japan) for seven consecutive days in the period 2008 to 2013. The final sample was 4647 Czech adults [M age 41...
October 24, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27782636/computation-of-indirect-nuclear-spin-spin-couplings-with-reduced-complexity-in-pure-and-hybrid-density-functional-approximations
#13
Arne Luenser, Jörg Kussmann, Christian Ochsenfeld
We present a (sub)linear-scaling algorithm to determine indirect nuclear spin-spin coupling constants at the Hartree-Fock and Kohn-Sham density functional levels of theory. Employing efficient integral algorithms and sparse algebra routines, an overall (sub)linear scaling behavior can be obtained for systems with a non-vanishing HOMO-LUMO gap. Calculations on systems with over 1000 atoms and 20 000 basis functions illustrate the performance and accuracy of our reference implementation. Specifically, we demonstrate that linear algebra dominates the runtime of conventional algorithms for 10 000 basis functions and above...
September 28, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27781176/ecological-solutions-to-reef-degradation-optimizing-coral-reef-restoration-in-the-caribbean-and-western-atlantic
#14
Diego Lirman, Stephanie Schopmeyer
Reef restoration activities have proliferated in response to the need to mitigate coral declines and recover lost reef structure, function, and ecosystem services. Here, we describe the recent shift from costly and complex engineering solutions to recover degraded reef structure to more economical and efficient ecological approaches that focus on recovering the living components of reef communities. We review the adoption and expansion of the coral gardening framework in the Caribbean and Western Atlantic where practitioners now grow and outplant 10,000's of corals onto degraded reefs each year...
2016: PeerJ
https://www.readbyqxmd.com/read/27766801/dengue-outbreak-2012-geo-mapping-and-snapshot-of-clinical-course-from-a-tertiary-referral-center-in-south-india
#15
Ganesh Veerasekar, Krishnan Swaminathan
BACKGROUND: Using technology to track endemic areas of communicable diseases is possible nowadays. Effectual use of such facilities, especially in developing countries, will increase earlier detection of cases as well as aid in the formulation of effective prevention strategies. METHODS: A retrospective data analysis was carried out by collecting the details of patients presented with positive dengue serology, during the outbreak season in the second half of 2012, at Kovai Medical Center and Hospital, Coimbatore, India...
October 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27765706/estimating-the-global-need-for-palliative-care-for-children-a-cross-sectional-analysis
#16
Stephen R Connor, Julia Downing, Joan Marston
CONTEXT: The need for children's palliative care (CPC) globally is unknown. In order to understand the scope of the need and to advocate to meet it, more accurate estimates are needed. OBJECTIVES: To create an accurate global estimate of the worldwide need for CPC based on a representative sample of countries from all regions of the world and all World Bank income groups. METHODS: This work builds on previously published methods developed by the International Children's Palliative Care Network, UNICEF, and WHO and tested in three African countries...
October 17, 2016: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/27764102/safety-of-seasonal-malaria-chemoprevention-smc-with-sulfadoxine-pyrimethamine-plus-amodiaquine-when-delivered-to-children-under-10-years-of-age-by-district-health-services-in-senegal-results-from-a-stepped-wedge-cluster-randomized-trial
#17
J L NDiaye, B Cissé, E H Ba, J F Gomis, C T Ndour, J F Molez, F B Fall, C Sokhna, B Faye, E Kouevijdin, F K Niane, M Cairns, J F Trape, C Rogier, O Gaye, B M Greenwood, P J M Milligan
BACKGROUND: It is recommended that children aged 3 months to five years of age living in areas of seasonal transmission in the sub-Sahel should receive Seasonal Malaria Chemoprevention (SMC) with sulfadoxine-pyrimethamine plus amodiaquine (SPAQ) during the malaria transmission season. The purpose of this study was to evaluate the safety of SMC with SPAQ in children when delivered by community health workers in three districts in Senegal where SMC was introduced over three years, in children from 3 months of age to five years of age in the first year, then in children up to 10 years of age...
2016: PloS One
https://www.readbyqxmd.com/read/27760253/multi-scale-strain-as-a-predictor-of-impact-induced-fissuring-in-articular-cartilage
#18
Corinne R Henak, Lena R Bartell, Itai Cohen, Lawrence J Bonassar
Mechanical damage is central to both initiation and progression of osteoarthritis (OA). However, specific causal links between mechanics and cartilage damage are incompletely understood, which results in an inability to predict failure. The lack of understanding is primarily due to the difficulty in simultaneously resolving the high rates and small length scales relevant to the problem and in correlating such measurements to the resulting fissures. This study leveraged microscopy and high-speed imaging to resolve mechanics on the previously unexamined time and length scales of interest in cartilage damage, and used those mechanics to develop predictive models...
October 19, 2016: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/27756459/progress-in-the-mathematical-modelling-of-visceral-leishmaniasis
#19
K S Rock, R J Quinnell, G F Medley, O Courtenay
The leishmaniases comprise a complex of diseases characterized by clinical outcomes that range from self-limiting to chronic, and disfiguring and stigmatizing to life threatening. Diagnostic methods, treatments, and vector and reservoir control options exist, but deciding the most effective interventions requires a quantitative understanding of the population level infection and disease dynamics. The effectiveness of any set of interventions has to be determined within the context of operational conditions, including economic and political commitment...
2016: Advances in Parasitology
https://www.readbyqxmd.com/read/27755860/trends-in-hospitalization-of-children-with-bacterial-pneumonia-in-poland
#20
Małgorzata Gajewska, Katarzyna Lewtak, Jacques Scheres, Piotr Albrecht, Paweł Goryński
AIM: The aim of the study was to evaluate the hospitalization trends in children aged 0-6 suffering from bacterial pneumonia in the years 2007-2011 in Poland. METHODS: The data pertained to the hospitalized patients diagnosed with the diseases registered as J13-J15 according to ICD-10. RESULTS: In the years 2007-2011, the hospitalization rate increased from 16.3/10,000 to 44.1/10,000 for boys and from 13.8/10,000 to 33.0/10,000 for girls. The most frequently hospitalized children were between 1 and 2 years of age (90...
September 2016: Central European Journal of Public Health
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