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https://www.readbyqxmd.com/read/29345704/hierarchical-core-shell-structures-of-p-ni-oh-2-rods-mno2-nanosheets-as-high-performance-cathode-materials-for-asymmetric-supercapacitors
#1
Kunzhen Li, Shikuo Li, Fangzhi Huang, Xin-Yao Yu, Yan Lu, Lei Wang, Hong Chen, Hui Zhang
The hierarchical porous structure with phosphorus-doped Ni(OH)2 (P-Ni(OH)2) rods as the core and MnO2 nanosheets as the shell is fabricated directly by growth on a three-dimensional (3D) flexible Ni foam (NF) via a two-step hydrothermal process. As a binder-free electrode material, this unique hybrid structure exhibits excellent electrochemical properties, including an ultrahigh areal capacitance of 5.75 F cm-2 at a current density of 2 mA cm-2 and great cyclic stability without capacitance loss at a current density of 20 mA cm-2 after 10 000 cycles...
January 18, 2018: Nanoscale
https://www.readbyqxmd.com/read/29336956/reverse-transcription-loop-mediated-isothermal-amplification-for-species-specific-detection-of-tomato-chlorotic-spot-orthotospovirus
#2
Xuelian Sui, Shouan Zhang, Zujian Wu, Kai-Shu Ling
Tomato chlorotic spot orthotospovirus (TCSV) is an emerging orthotospovirus that can cause severe disease on tomato plants. There are at least four orthotospoviruses infecting tomato, and mixed infection of two or more orthotospoviruses in a single tomato plant is quite common in the field. With similarity in the symptomatology and cross serological reactivity among tomato-infecting orthotospoviruses, especially between TCSV and groundnut ringspot orthotospovirus (GRSV), the current serological tests could not achieve definite and accurate species-specific determination in disease diagnosis...
January 11, 2018: Journal of Virological Methods
https://www.readbyqxmd.com/read/29335328/walking-prescription-of-10-000-steps-per-day-in-patients-with-type-2-diabetes-mellitus-a-randomised-trial-in-nigerian-general-practice
#3
Ayorinde F Fayehun, Olufemi O Olowookere, Adetola M Ogunbode, Adedotun A Adetunji, Arinola Esan
BACKGROUND: In clinical practice, translating the benefits of a sustained physically active lifestyle on glycaemic control in patients with type 2 diabetes mellitus (T2DM) is difficult. A walking prescription may be an effective alternative. AIM: To examine the effect of a 10 000 steps per day prescription on glycaemic control of patients with T2DM. DESIGN AND SETTING: Forty-six adults with T2DM attending a general outpatient clinic were randomised into two equal groups...
January 15, 2018: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/29326906/a-comparison-of-ground-reaction-force-components-according-to-the-foothold-heights-in-16-t-truck-during-downward-step
#4
Seung-Hyun Hyun, Che-Cheong Ryew
The aim of this study is to compare and analyze the components of ground reaction force (GRF) relative to the foothold heights during downward step of 16-t truck. Adult males (n= 10) jumped downward from each 1st, 2nd, 3rd foothold step and driver's seat orderly using hand rail. Sampling rate of force components of 3 axis (medial-lateral [ML] GRF, anterior-posterior [AP] GRF, peak vertical force [PVF]), variables (COPx, COPy, COP area) of center of pressure (COP), loading rate, and stability index (ML, AP, vertical, and dynamic postural stability index [DPSI]) processed from GRF system was cut off at 1,000 Hz...
December 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/29323531/an-efficient-gas-chromatography-mass-spectrometry-approach-for-the-simultaneous-analysis-of-deoxynivalenol-and-its-bacterial-metabolites-3-keto-don-and-3-epi-don
#5
Kaijie Tang, Huaizhi Liu, Xiu-Zhen Li, Yousef I Hassan, Suqin Shao, Ting Zhou
Deoxynivalenol (DON) is one of the major toxic secondary metabolites produced by Fusarium fungi in cereal grains. Among the many promising strategies of DON detoxification are the microbial and enzymatic ones, which transform DON to nontoxic DON metabolites. Thus, proper analytical methods are needed for those DON metabolites. In this study, a robust gas chromatography-mass spectrometry (GC-MS) procedure was developed and validated for the simultaneous analysis of DON and two of its bacterial metabolites, 3-keto-DON and 3- epi-DON...
January 11, 2018: Journal of Food Protection
https://www.readbyqxmd.com/read/29319246/dengue-outbreak-2012-geo-mapping-and-snapshot-of-clinical-course-from-a-tertiary-referral-center-in-south-india
#6
Ganesh Veerasekar, Krishnan Swaminathan
Background: Using technology to track endemic areas of communicable diseases is possible nowadays. Effectual use of such facilities, especially in developing countries, will increase earlier detection of cases as well as aid in the formulation of effective prevention strategies. Methods: A retrospective data analysis was carried out by collecting the details of patients presented with positive dengue serology, during the outbreak season in the second half of 2012, at Kovai Medical Center and Hospital, Coimbatore, India...
October 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29315921/influence-of-physical-inactivity-on-arterial-compliance-during-a-glucose-challenge
#7
Daniel P Credeur, Leryn J Reynolds, Seth W Holwerda, Jennifer R Vranish, Benjamin E Young, Jing Wang, John P Thyfault, Paul J Fadel
Acute hyperglycemia has been shown to augment indices of arterial stiffness in patients with insulin resistance and other co-morbidities, however, conflicting results exist in healthy young individuals. We examined if acute hyperglycemia following an oral glucose tolerance test (OGTT) increases arterial stiffness in healthy active men before, and then after reduced ambulatory physical activity to decrease insulin sensitivity. High-resolution arterial diameter tracings acquired from Doppler-ultrasound allowed the obtainment of an arterial blood pressure (BP) waveform from the diameter tracing within a cardiac cycle...
January 9, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29301389/the-effect-of-primary-levels-and-frequencies-on-the-contralateral-suppression-of-distortion-product-otoacoustic-emission
#8
Natalia Yakunina, Jinsook Kim, Eui-Cheol Nam
Background and Objectives: Changes in distortion product otoacoustic emission (DPOAE) caused by contralateral suppression (CS) allow the function of the auditory efferent system to be evaluated. Parameters affording maximum CS are preferred in terms of clinical application. Our objective was to evaluate the effects of primary levels and frequencies on DPOAEmediated CS. Subjects and Methods: Sixteen subjects with normal hearing participated. DPOAEs were recorded with and without contralateral acoustic stimulation; we delivered broadband noise of 65 dB SPL at f2 frequencies between 1,000 Hz and 6,727 Hz, at 8 pt/ octave...
January 5, 2018: Journal of Audiology & Otology
https://www.readbyqxmd.com/read/29299602/effect-of-standardized-handoff-curriculum-on-improved-clinician-preparedness-in-the-intensive-care-unit-a-stepped-wedge-cluster-randomized-clinical-trial
#9
Brodie Parent, Lacey N LaGrone, Mohamed T Albirair, Peter T Serina, Jonathan M Keller, Joseph Cuschieri, Erin J Addison, Lapio Choe, Genecelle B Delossantos, Cameron E Gaskill, Sarah D Moon, Jestine T MacDonald, Matthew J Stolzberg, Erik G Van Eaton, Jennifer M Zech, Patricia A Kritek
Importance: Clinician miscommunication contributes to an estimated 250 000 deaths in US hospitals per year. Efforts to standardize handoff communication may reduce errors and improve patient safety. Objective: To determine the effect of a standardized handoff curriculum, UW-IPASS, on interclinician communication and patient outcomes. Design, Setting, and Participants: This cluster randomized stepped-wedge randomized clinical trial was conducted from October 2015 to May 2016 at 8 medical and surgical intensive care units at 2 hospital systems within an academic tertiary referral center...
January 3, 2018: JAMA Surgery
https://www.readbyqxmd.com/read/29296663/computer-assisted-retrosynthesis-based-on-molecular-similarity
#10
Connor W Coley, Luke Rogers, William H Green, Klavs F Jensen
We demonstrate molecular similarity to be a surprisingly effective metric for proposing and ranking one-step retrosynthetic disconnections based on analogy to precedent reactions. The developed approach mimics the retrosynthetic strategy defined implicitly by a corpus of known reactions without the need to encode any chemical knowledge. Using 40 000 reactions from the patent literature as a knowledge base, the recorded reactants are among the top 10 proposed precursors in 74.1% of 5000 test reactions, providing strong quantitative support for our methodology...
December 27, 2017: ACS Central Science
https://www.readbyqxmd.com/read/29287089/discovery-of-novel-orally-bioavailable-antileishmanial-compounds-using-phenotypic-screening
#11
Diana Ortiz, W Armand Guiguemde, Jared T Hammill, Angela K Carrillo, Yizhe Chen, Michele Connelly, Kayla Stalheim, Carolyn Elya, Alex Johnson, Jaeki Min, Anang Shelat, David C Smithson, Lei Yang, Fangyi Zhu, R Kiplin Guy, Scott M Landfear
Leishmaniasis is a parasitic infection that afflicts approximately 12 million people worldwide. There are several limitations to the approved drug therapies for leishmaniasis, including moderate to severe toxicity, growing drug resistance, and the need for extended dosing. Moreover, miltefosine is currently the only orally available drug therapy for this infection. We addressed the pressing need for new therapies by pursuing a two-step phenotypic screen to discover novel, potent, and orally bioavailable antileishmanials...
December 29, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29286450/deep-proteome-profiling-by-isobaric-labeling-extensive-liquid-chromatography-mass-spectrometry-and-software-assisted-quantification
#12
Anthony A High, Haiyan Tan, Vishwajeeth R Pagala, Mingming Niu, Ji-Hoon Cho, Xusheng Wang, Bing Bai, Junmin Peng
Many exceptional advances have been made in mass spectrometry (MS)-based proteomics, with particular technical progress in liquid chromatography (LC) coupled to tandem mass spectrometry (LC-MS/MS) and isobaric labeling multiplexing capacity. Here, we introduce a deep-proteomics profiling protocol that combines 10-plex tandem mass tag (TMT) labeling with an extensive LC/LC-MS/MS platform, and post-MS computational interference correction to accurately quantitate whole proteomes. This protocol includes the following main steps: protein extraction and digestion, TMT labeling, 2-dimensional (2D) LC, high-resolution mass spectrometry, and computational data processing...
November 15, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29240685/fibrinogen-as-a-pleiotropic-protein-causing-human-diseases-the-mutational-burden-of-a%C3%AE-b%C3%AE-and-%C3%AE-chains
#13
Elvezia Maria Paraboschi, Stefano Duga, Rosanna Asselta
Fibrinogen is a highly pleiotropic protein that is involved in the final step of the coagulation cascade, wound healing, inflammation, and angiogenesis. Heterozygous mutations in Aα, Bβ, or γ fibrinogen-chain genes (FGA, FGB, FGG) have been described as being responsible for fibrinogen deficiencies (hypofibrinogenemia, hypo-dysfibrinogenemia, dysfibrinogenemia) and for more rare conditions, such as fibrinogen storage disease and hereditary renal amyloidosis. Instead, biallelic mutations have been associated with afibrinogenemia/severe hypofibrinogenemia, i...
December 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29238434/predictors-of-achieving-recommended-daily-physical-activity-among-anesthesiologists-at-a-large-tertiary-care-academic-center
#14
Vesela P Kovacheva, Lawrence C Tsen
Background: The goal of the current study was to determine if the daily work patterns of anesthesiologists meet the recommended daily levels of activity. Methods: Attending and resident anesthesiologists at a tertiary academic center were invited to participate. The subjects wore a pedometer during five regular clinical days at work and recorded the number of steps walked. The participants also completed the International Physical Activity Questionnaire (IPAQ) during one regular week...
January 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29238173/a-light-assisted-in-situ-embedment-of-silver-nanoparticles-to-prepare-functionalized-fabrics
#15
Her Shuang Toh, Roxanne Line Faure, Liyana Bte Mohd Amin, Crystal Yu Fang Hay, Saji George
This article presents a simple, one-step, in situ generation of silver nanoparticle-functionalized fabrics with antibacterial properties, circumventing the conventional, multistep, time-consuming methods. Silver nanoparticle formation was studied with a library of capping agents (branched polyethylenimine [BPEI] of molecular weight [Mw] 10,000 and 25,000, polyvinylpyrrolidone, polyethylene glycol, polyvinylalcohol and citrate) mixed with silver nitrate. The mixture was then exposed to an assortment of light wavelengths (ultraviolet, infrared and simulated solar light) for studying the light-assisted synthesis of nanoparticles...
2017: Nanotechnology, Science and Applications
https://www.readbyqxmd.com/read/29203114/a-simultaneous-screening-and-quantitative-method-for-the-multiresidue-analysis-of-pesticides-in-spices-using-ultra-high-performance-liquid-chromatography-high-resolution-orbitrap-mass-spectrometry
#16
Arnab Goon, Zareen Khan, Dasharath Oulkar, Raviraj Shinde, Suresh Gaikwad, Kaushik Banerjee
A novel screening and quantitation method is reported for non-target multiresidue analysis of pesticides using ultra-HPLC-quadrupole-Orbitrap mass spectrometry in spice matrices, including black pepper, cardamom, chili, coriander, cumin, and turmeric. The method involved sequential full-scan (resolution = 70,000), and variable data independent acquisition (vDIA) with nine consecutive fragmentation events (resolution = 17,500). Samples were extracted by the QuEChERS method. The introduction of an SPE-based clean-up step through hydrophilic-lipophilic-balance (HLB) cartridges proved advantageous in minimizing the false negatives...
November 29, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29202360/enhanced-capillary-electrophoretic-screening-of-alzheimer-based-on-direct-apolipoprotein-e-genotyping-and-one-step-multiplex-pcr
#17
Nain Woo, Su-Kang Kim, Yucheng Sun, Seong Ho Kang
Human apolipoprotein E (ApoE) is associated with high cholesterol levels, coronary artery disease, and especially Alzheimer's disease. In this study, we developed an ApoE genotyping and one-step multiplex polymerase chain reaction (PCR) based-capillary electrophoresis (CE) method for the enhanced diagnosis of Alzheimer's. The primer mixture of ApoE genes enabled the performance of direct one-step multiplex PCR from whole blood without DNA purification. The combination of direct ApoE genotyping and one-step multiplex PCR minimized the risk of DNA loss or contamination due to the process of DNA purification...
November 27, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29194709/low-grade-spindle-cell-proliferation-in-clear-cell-renal-cell-carcinoma-is-unlikely-to-be-an-initial-step-in-sarcomatoid-differentiation
#18
Ozlem Tanas Isikci, Huying He, Petr Grossmann, Reza Alaghehbandan, Monika Ulamec, Kvetoslava Michalova, Kristyna Pivovarcikova, Delia Perez Montiel, Ondrej Ondic, Ondrej Daum, Kristyna Prochazkova, Milan Hora, Michal Michal, Ondrej Hes
Spindle cell proliferation within clear cell renal cell carcinoma (ccRCC) is usually considered as sarcomatoid differentiation. Low-grade spindle cell proliferation (LG-SCP) in ccRCC was first described in 2001. This phenomenon is not common and can pose diagnostic challenges particularly in core biopsies. The aim of this study was to describe morphologic, immunohistochemical and molecular characteristics of ccRCCs with LG-SCP. 11 cases of ccRCC with LG-SCP were retrieved from approximately 21,000 renal tumors in our registry...
December 1, 2017: Histopathology
https://www.readbyqxmd.com/read/29171231/-bioactivity-guided-isolation-of-anti-angiotensin-converting-enzyme-constituents-from-trichosanthis-pericarpium
#19
Hui-Jun Wang, Ying Ke, Guan Ye
To isolate the anti-angiotensin converting enzyme (ACE) constituents from Trichosanthis Pericarpium based on bioactivity-guided separation. Trichosanthis Pericarpium was extracted with boiling water and precipitated by ethanol, then its supernatant was collected and dialyzed. The retentate of the fractions above 1 000 was lyophilized to obtain GLP, which was then successively separated by DEAE Sepharose fast flow anion-exchange and Superdex-75 gel permeation chromatographic steps to achieve GLP-1-1. A combination of HPGPC, monosaccharide compositions determination and ACE inhibitory activity studies was performed to investigate the structure and bioactivity...
August 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29165168/certain-personal-and-environmental-factors-as-predictors-of-thermal-sensation-perceived-by-a-population-of-students-in-a-university-setting-from-timisoara-romania-a-case-study
#20
Cristina I Petrescu
BACKGROUND: The aim of the performed study was to investigate personal and environmental factors as predictors of thermal sensation perceived by a population of students in a university setting. METHODS: The study consisted of two samples, a winter sample (154 students: 44.2% males and 55.8% females, aged 19-30 years) and a spring sample (147 students: 52.4% males and 47.6% females, aged 19-30 years), randomly selected from the same population of students. The method was an observational inquiry (case study) with a standardized questionnaire (11 items, 3 items for thermal sensation assessing through 3 scales with 3, 5 and 7 steps, alpha Cronbach's index 0...
June 14, 2017: Environmental Health and Preventive Medicine
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