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https://www.readbyqxmd.com/read/28713583/effects-of-supervised-and-unsupervised-physical-activity-programmes-for-weight-loss
#1
S A Creasy, R J Rogers, K K Davis, B B Gibbs, E E Kershaw, J M Jakicic
OBJECTIVES: Physical activity is important for weight management. However, it remains unclear what type of physical activity prescription/programme is optimal for increasing physical activity during a standard behavioural weight loss intervention. This study examined changes in physical activity after a 12-week supervised programme prescribed in minutes per week (SUP-PA), an unsupervised programme prescribed in minutes per week (UNSUP-PA) and an unsupervised programme prescribed in steps per day (STEP)...
June 2017: Obesity Science & Practice
https://www.readbyqxmd.com/read/28709683/10-000-steps-into-the-digital-age
#2
EDITORIAL
C Johnman, P Mackie, F Sim
No abstract text is available yet for this article.
July 11, 2017: Public Health
https://www.readbyqxmd.com/read/28691390/an-improved-digital-polymerase-chain-reaction-protocol-to-capture-low-copy-kras-mutations-in-plasma-cell-free-dna-by-resolving-subsampling-issues
#3
REVIEW
Yusuke Ono, Ayumu Sugitani, Hidenori Karasaki, Munehiko Ogata, Reo Nozaki, Junpei Sasajima, Tomoki Yokochi, Shingo Asahara, Kazuya Koizumi, Kiyohiro Ando, Katsunori Hironaka, Tsutomu Daito, Yusuke Mizukami
Genetic alterations responsible for the initiation of cancer may serve as immediate biomarkers for early diagnosis. Plasma levels of cell-free DNA (cfDNA) in cancer patients are higher than those in healthy individuals, however, the major technical challenge for the widespread implementation of cfDNA genotyping as a diagnostic tool is the insufficient sensitivity and specificity of detecting early-stage tumors that shed low amounts of cfDNA. To establish a protocol for ultrasensitive droplet digital polymerase chain reaction (ddPCR) for quantification of low-frequency alleles within a limited cfDNA pool, two-step multiplex ddPCR targeting eight clinically relevant mutant KRAS variants was examined...
July 10, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/28689649/epispadias-repair-with-tunica-vaginalis-flap
#4
R S Zee, J H Makari, Fernando Ferrer, C D A Herndon
INTRODUCTION: Primary epispadias is a rare congenital malformation that afflicts about 1 in 80,000 children. The surgical repair, originally described by Cantwell over 100 years ago, is fundamentally sound and incorporates several important steps to achieve an optimal result. METHODS: A 9-month-old male with penopubic epispadias presented for surgical repair. Pre-operative imaging included a normal renal ultrasound and voiding cystourethrogram that demonstrated a moderate-sized bladder, partially competent bladder neck, and no vesicoureteral reflux...
June 27, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28683073/high-throughput-electrophysiological-assays-for-voltage-gated-ion-channels-using-syncropatch-768pe
#5
Tianbo Li, Gang Lu, Eugene Y Chiang, Tania Chernov-Rogan, Jane L Grogan, Jun Chen
Ion channels regulate a variety of physiological processes and represent an important class of drug target. Among the many methods of studying ion channel function, patch clamp electrophysiology is considered the gold standard by providing the ultimate precision and flexibility. However, its utility in ion channel drug discovery is impeded by low throughput. Additionally, characterization of endogenous ion channels in primary cells remains technical challenging. In recent years, many automated patch clamp (APC) platforms have been developed to overcome these challenges, albeit with varying throughput, data quality and success rate...
2017: PloS One
https://www.readbyqxmd.com/read/28668276/a-walking-intervention-among-men-with-prostate-cancer-a-pilot-study
#6
Claire H Pernar, Katja Fall, Jennifer R Rider, Sarah C Markt, Hans-Olov Adami, Sven-Olof Andersson, Unnur Valdimarsdottir, Ove Andrén, Lorelei A Mucci
BACKGROUND: Men diagnosed with prostate cancer have increased risk for disease progression, cardiovascular events, and impairments in quality of life. This pilot study evaluated the feasibility of a randomized walking group intervention to improve quality of life, circulating biomarkers, and morbidity among men with newly diagnosed prostate cancer. METHODS: Men were recruited at Örebro University Hospital, Sweden, and randomized to an 11-week walking group intervention (n = 21) or usual care (n = 20)...
May 31, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28666177/accuracy-of-step-count-measured-by-physical-activity-monitors-the-effect-of-gait-speed-and-anatomical-placement-site
#7
Jessica J Chow, Jeanette M Thom, Michael A Wewege, Rachel E Ward, Belinda J Parmenter
INTRODUCTION: Consumer-based physical activity monitors (PAMs) are becoming increasingly popular, with multiple global organisations recommending physical activity levels that equate to 10,000 steps per day for optimal health. We therefore aimed to compare the step count of five PAMs to a visual step count to identify the most accurate monitors at varying gait speeds, along with the optimal anatomical placement site. METHODS: Participants completed 3min on a treadmill for five speeds (5...
June 21, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28650973/interferon-signaling-in-peromyscus-leucopus-confers-a-potent-and-specific-restriction-to-vector-borne-flaviviruses
#8
Adaeze O Izuogu, Kristin L McNally, Stephen E Harris, Brian H Youseff, John B Presloid, Christopher Burlak, Jason Munshi-South, Sonja M Best, R Travis Taylor
Tick-borne flaviviruses (TBFVs), including Powassan virus and tick-borne encephalitis virus cause encephalitis or hemorrhagic fevers in humans with case-fatality rates ranging from 1-30%. Despite severe disease in humans, TBFV infection of natural rodent hosts has little noticeable effect. Currently, the basis for resistance to disease is not known. We hypothesize that the coevolution of flaviviruses with their respective hosts has shaped the evolution of potent antiviral factors that suppress virus replication and protect the host from lethal infection...
2017: PloS One
https://www.readbyqxmd.com/read/28640436/two-step-irradiance-schedule-versus-single-dose-cold-compress-for-pain-control-during-5-aminolevulinic-acid-based-photodynamic-therapy-of-condyloma-acuminatum
#9
Xiaonan Shao, Fang Wang, Bin Xu
OBJECTIVE: The purpose of this study was to investigate the effect of two-step irradiance schedule in relieving pain during PDT of CA. METHODS: The study was a prospective, controlled trial of 141 CA patients who were randomly divided into Group A (two-step irradiance schedule) and Group B (single-dose cold compress). The numeric rating scales (NRS) of patients' pain were recorded at 5, 10, 15, and 20 minutes during each PDT. RESULTS: The efficacy of PDT and NRS scores of patients in the two groups were compared...
June 22, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28627013/regular-exercise-improves-the-well-being-of-parents-of-children-with-cancer
#10
Gail C Halliday, Gordon C P Miles, Julie A Marsh, Rishi S Kotecha, Angela J Alessandri
AIM: Parents of children with cancer describe impaired physical and social functioning, sleep disturbance and poor mental health. Exercise-related interventions impact positively on these quality of life domains, but have not been examined in this population. The aim of this longitudinal pilot study was to explore the feasibility of a 12-week pedometer-monitored walking intervention among parents of children with cancer, assessing adherence to a set activity target of 70,000 steps per week, and to explore the benefits of physical activity on mental and physical health...
June 19, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28616288/decreased-expression-of-perforin-in-cd8-t-lymphocytes-in-patients-with-mycobacterium-tuberculosis-infection-and-its-potential-value-as-a-marker-for-efficacy-of-treatment
#11
Hongbin Jiang, Huili Gong, Qing Zhang, Jin Gu, Li Liang, Jun Zhang
BACKGROUND: Cytolytic activity against mycobacteria tuberculosis (MTB) within the infected macrophage is a crucial step in the immunity against TB infection, as MTB is an intracellular bacterium. Cytotoxic molecules such as perforin and granzymes produced by cytolytic T cells directly participate in this process. In this study, we evaluated the cytotoxicity function employing flow cytometry analysis of the level of expression of interferon-γ (IFN-γ), perforin and granzyme B in CD8(+) T cells from patients with active pulmonary TB (PTB), stable PTB and healthy controls, and explored whether MTB antigen (MTB Ag)-stimulated cytotoxic molecules would be useful for monitoring responses to anti-TB treatment...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28591145/successful-implementation-of-helping-babies-survive-and-helping-mothers-survive-programs-an-utstein-formula-for-newborn-and-maternal-survival
#12
Hege L Ersdal, Nalini Singhal, Georgina Msemo, Ashish Kc, Santorino Data, Nester T Moyo, Cherrie L Evans, Jeffrey Smith, Jeffrey M Perlman, Susan Niermeyer
Globally, the burden of deaths and illness is still unacceptably high at the day of birth. Annually, approximately 300.000 women die related to childbirth, 2.7 million babies die within their first month of life, and 2.6 million babies are stillborn. Many of these fatalities could be avoided by basic, but prompt care, if birth attendants around the world had the necessary skills and competencies to manage life-threatening complications around the time of birth. Thus, the innovative Helping Babies Survive (HBS) and Helping Mothers Survive (HMS) programs emerged to meet the need for more practical, low-cost, and low-tech simulation-based training...
2017: PloS One
https://www.readbyqxmd.com/read/28588891/prevalence-and-clinical-features-of-opioid-induced-constipation-in-the-general-population-a-french-study-of-15-000-individuals
#13
P Ducrotté, J Milce, C Soufflet, C Fabry
BACKGROUND: Constipation is common during opioid therapy and can compromise analgesia. AIM: The aim of this article is to determine the prevalence and clinical characteristics of opioid-induced constipation (OIC) in France. METHODS: A questionnaire study was conducted in a representative sample of the French general population. Participants completed a 31-item questionnaire covering opioid use during the previous six months, and the occurrence of constipation (defined as <3 bowel movements per week, straining during defaecation, or both) during opioid treatment...
June 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28582480/pastaspark-multiple-sequence-alignment-meets-big-data
#14
José M Abuín, Tomás F Pena, Juan C Pichel
Motivation: One basic step in many bioinformatics analyses is the Multiple Sequence Alignment (MSA). One of the state of the art tools to performMSA is PASTA (Practical Alignments using SATé and TrAnsitivity). PASTA supportsmultithreading but it is limited to process datasets on shared memory systems. In this work we introduce PASTASpark, a tool that uses the Big Data engine Apache Spark to boost the performance of the alignment phase of PASTA, which is the most expensive task in terms of time consumption...
June 5, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28582398/effects-of-low-powered-rf-sweep-between-0-01-20-ghz-on-female-aedes-aegypti-mosquitoes-a-collective-behaviour-analysis
#15
Abdul Halim Poh, Mahmoud Moghavvemi, M M Shafiei, C S Leong, Yee Ling Lau, Faisal Rafiq Mahamd Adikan, Majid Bakhtiari, Mahmood Ameen Abdulla Hassan
There are many products claiming to be an electronic solution towards repelling mosquitoes. Several reviews were published in debunking these claims. However, there is a lack of a systematic study on effects of electromagnetic (EM) or more specifically, radio frequency (RF) waves against mosquitoes due to the conclusions made in those years. Therefore, we attempt to establish a fundamental study on female Aedes Aegypti (Linnaeus) mosquitoes by quantifying the collective behavior of the mosquitoes against a continuous stream of low-powered RF signals via a broadband horn antenna using image processing methods...
2017: PloS One
https://www.readbyqxmd.com/read/28575141/objectively-measured-physical-activity-and-kidney-function-in-older-men-a-cross-sectional-population-based-study
#16
Tessa J Parsons, Claudio Sartini, Sarah Ash, Lucy T Lennon, S Goya Wannamethee, I-Min Lee, Peter H Whincup, Barbara J Jefferis
Background: kidney function declines in older adults and physical activity levels are low. We investigated whether higher levels of physical activity and lower levels of sedentary behaviour were associated with lower odds of low kidney function in older men. Methods: cross-sectional study of 1,352 men from the British Regional Heart Study, mean (standard deviation) age 78.5 (4.6) year. Physical activity and sedentary behaviour were measured using Actigraph GT3X accelerometers...
June 1, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28574074/atomic-scale-deposition-of-pt-around-au-nanoparticles-to-achieve-much-enhanced-electrocatalysis-of-pt
#17
Zheng Xi, Haifeng Lv, Daniel P Erdosy, Dong Su, Qing Li, Chao Yu, Junrui Li, Shouheng Sun
We report an electrochemical method to deposit atomic scale Pt on a 5 nm Au nanoparticle (NP) surface in N2-saturated 0.5 M H2SO4. Pt is provided by the Pt wire counter electrode via one-step Pt wire oxidation, dissolution, and deposition realized by controlled electrochemical scanning. Scanning from 0.6-1.0 V (vs. RHE) for 10 000 cycles gives Au98.2Pt1.8, which serves as an excellent catalyst for the formic acid oxidation reaction, showing 41 times higher specific activity (20.19 mA cm(-2)) and 25 times higher mass activity (10...
June 2, 2017: Nanoscale
https://www.readbyqxmd.com/read/28567679/androgens-oestrogens-and-progesterone-concentrations-in-wastewater-purification-processes-measured-with-capillary-electrophoresis
#18
Heli Sirén, Samira El Fellah
A novel analytical-scale concept to improve reliability of detection and analysis of natural and processed wastewater samples from a purification plant was developed. A sequential sample clean-up system of polymer-based octadecyl and silane-based quaternary amine sorbents were used for concentrating human based steroid hormones and their metabolites and detecting them by UV absorption with capillary electrophoresis (CE). The water samples were collected from influent and effluent processes of the water purification plant in Helsinki, Finland...
July 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28551048/randomized-study-comparing-equal-height-staples-with-graduated-height-staples-in-bronchial-closure
#19
Jiro Okami, Toshiteru Tokunaga, Takashi Kanou, Hidenori Kunou, Daisuke Ishida, Ayako Fujiwara, Yuri Ito, Masahiko Higashiyama
BACKGROUND: There are two forms of staple cartridge available for lung cancer operations, the flat face with equal height staples and the stepped face with graduated height staples. The objective of the study was to evaluate their stapling ability in lobectomy. METHODS: A randomized prospective study was conducted to compare two types of stapling reloads for bronchial closure. Stapling ability was evaluated by the staple formation on the resected bronchial stump...
May 24, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28549882/trends-in-the-use-of-laboratory-tests-for-the-diagnosis-of-clostridium-difficile-infection-and-association-with-incidence-rates-in-quebec-canada-2010-2014
#20
C Bogaty, S Lévesque, C Garenc, C Frenette, D Bolduc, L-A Galarneau, C Lalancette, V Loo, C Tremblay, M Trudeau, J Vachon, M Dionne, J Villeneuve, J Longtin, Y Longtin
BACKGROUND: Several Clostridium difficile infection (CDI) surveillance programs do not specify laboratory strategies to use. We investigated the evolution in testing strategies used across Quebec, Canada, and its association with incidence rates. METHODS: Cross-sectional study of 95 hospitals by surveys conducted in 2010 and in 2013-2014. The association between testing strategies and institutional CDI incidence rates was analyzed via multivariate Poisson regressions...
May 23, 2017: American Journal of Infection Control
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