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https://www.readbyqxmd.com/read/29219057/formulation-optimization-and-in-vitro-and-in-vivo-evaluation-of-lornoxicam-ethosomal-gels-with-penetration-enhancers
#1
Keke Li, Shanshan Gao, Baocheng Tian, Yanan Shi, Qingzhi Lv, Jingtian Han
BACKGROUND: Ethosomes, a novel type of percutaneous drug delivery carrier with a lipid bilayer structure, penetrate the skin barrier due to their deformability and malleability, and presence of ethanol that fluidizes lipids in the skin. In order to further enhance the delivery of drugs through the skin, penetration enhancers are widely used. OBJECTIVE: The objective of this work was to develop an optimized formulation of lornoxicam ethosomal gels, investigate skin permeability with the addition of penetration enhancers, and evaluate the in vivo pharmacodynamics of these formulations...
December 7, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/29216159/cross-correlation-photothermal-optical-coherence-tomography-with-high-effective-resolution
#2
Peijun Tang, Shaojie Liu, Junbo Chen, Zhiling Yuan, Bingkai Xie, Jianhua Zhou, Zhilie Tang
We developed a cross-correlation photothermal optical coherence tomography (CC-PTOCT) system for photothermal imaging with high lateral and axial resolution. The CC-PTOCT system consists of a phase-sensitive OCT system, a modulated pumping laser, and a digital cross-correlator. The pumping laser was used to induce the photothermal effect in the sample, causing a slight phase modulation of the OCT signals. A spatial phase differentiation method was employed to reduce phase accumulation. The noise brought by the phase differentiation method and the strong background noise were suppressed efficiently by the cross-correlator, which was utilized to extract the photothermal signals from the modulated signals...
December 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/29214897/ss-31-peptide-enables-mitochondrial-targeting-drug-delivery-a-promising-therapeutic-alteration-to-prevent-hair-cell-damage-from-aminoglycosides
#3
Xiao Kuang, Shuang Zhou, Weiling Guo, Zhenjie Wang, Yanhui Sun, Hongzhuo Liu
Aminoglycoside-induced hearing loss stems from damage or loss of mechanosensory hair cells in the inner ear. Intrinsic mitochondrial cell death pathway plays a key role in that cellular dysfunction for which no proven effective therapies against oto-toxicities exist. Therefore, the aim of the present study was to develop a new mitochondrial targeting drug delivery system (DDS) that provided improved protection from gentamicin. Particularly, SS-31 peptide-conjugated geranylgeranylacetone (GGA) loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles were constructed successfully via emulsion-solvent evaporation method...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/29214789/microrna-183-is-essential-for-hair-cell-regeneration-after-neomycin-injury-in-zebrafish
#4
Chang Woo Kim, Ji Hyuk Han, Ling Wu, Jae Young Choi
PURPOSE: microRNAs (miRNAs) are non-coding RNAs composed of 20 to 22 nucleotides that regulate development and differentiation in various organs by silencing specific RNAs and regulating gene expression. In the present study, we show that the microRNA (miR)-183 cluster is upregulated during hair cell regeneration and that its inhibition reduces hair cell regeneration following neomycin-induced ototoxicity in zebrafish. MATERIALS AND METHODS: miRNA expression patterns after neomycin exposure were analyzed using microarray chips...
January 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29214174/feasibility-of-round-window-stimulation-by-a-novel-electromagnetic-microactuator
#5
Wouter Johannes van Drunen, Mathias Mueller, Anatoly Glukhovskoy, Rolf Salcher, Marc Christopher Wurz, Thomas Lenarz, Hannes Maier
Introduction: Most implantable hearing aids currently available were developed to compensate the sensorineural hearing loss by driving middle ear structures (e.g., the ossicles). These devices are successfully used in round window (RW) stimulation clinically, although this was initially not the intended use. Here, a novel microactuator, specifically designed for RW stimulation, was tested in human temporal bones to determine actuator performance and applicability. Methods: Stapes footplate response to RW stimulation was determined experimentally in human temporal bones and the obtained sound pressure output level was estimated...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29213239/dynamic-editome-of-zebrafish-under-aminoglycosides-treatment-and-its-potential-involvement-in-ototoxicity
#6
Sijia Yan, Yulan Lu, Lin He, Xinzhi Zhao, Lihua Wu, Huizhong Zhu, Menglin Jiang, Yu Su, Wei Cao, Weidong Tian, Qinghe Xing
RNA editing is an important co- and post-transcriptional event that generates RNA and protein diversity. Aminoglycosides are a group of bactericidal antibiotics and a mainstay of antimicrobial therapy for several life-threatening infections. However, aminoglycosides can induce ototoxicity, resulting in damage to the organs responsible for hearing and balance. At low concentrations, aminoglycosides can bind to many RNA sequences and critically influence RNA editing. We used a bioinformatics approach to investigate the effect of aminoglycosides on global mRNA editing events to gain insight into the interactions between mRNA editing and aminoglycoside ototoxicity...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29212187/autophagy-protein-lc3-regulates-the-fibrosis-of-hypertrophic-scar-by-controlling-bcl-xl-in-dermal-fibroblasts
#7
Jihong Shi, Shan Shi, Bin Wu, Jian Zhang, Yan Li, Xue Wu, Julei Zhang, Kejia Wang, Bin Zhao, Weixia Cai, Xiaozhi Bai, Dahai Hu, Hao Guan
Hypertrophic scar (HS) is a serious skin fibrotic disease characterized by excessive hypercellularity and extracellular matrix (ECM) component deposition. Autophagy is a tightly regulated physiological process essential for cellular maintenance, differentiation, development and homeostasis. However, during the formation of HS, whether and how autophagy is regulated in dermal fibroblasts are still far from elucidated. Here we detected the autophagic capacity in HS and normal skin (NS) counterparts, explored and verified the key regulatory molecules of autophagy in HS-derived fibroblasts (HSFs), and validated the data using rabbit ear scar model...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29211547/prenatal-exposure-to-polychlorinated-biphenyls-and-asthma-eczema-hay-fever-and-frequent-ear-infections
#8
Margaret Parker-Lalomio, Kenneth McCann, Julie Piorkowski, Sally Freels, Victoria W Persky
OBJECTIVES: The effects of prenatal exposure to Polychlorinated biphenyls (PCBs) on the development of asthma, frequent ear infections, and eczema/hay fever are not well understood. We aim to investigate associations between prenatal PCB exposure and these health outcomes in the offspring of women who worked at the LaSalle Electrical Utilities Company (EUC). METHODS: A retrospective cohort with at least one live birth and known employment time at EUC was eligible for this analysis...
December 6, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29210947/toward-optimizing-cervical-vestibular-evoked-myogenic-potentials-cvemp-combining-air-bone-gap-and-cvemp-thresholds-to-improve-diagnosis-of-superior-canal-dehiscence
#9
Kimberley S Noij, Maria J Duarte, Kevin Wong, Y Song Cheng, Salwa Masud, Barbara S Herrmann, Hugh D Curtin, Vivek V Kanumuri, John J Guinan, Elliott D Kozin, Osama Tarabichi, David H Jung, Daniel J Lee, Steven D Rauch
OBJECTIVE: To develop a novel approach combining low-frequency air-bone gap (ABG) and cervical vestibular evoked myogenic potential (cVEMP) thresholds to improve screening for superior canal dehiscence (SCD) syndrome. STUDY DESIGN: Retrospective study. SETTING: Tertiary care center. PATIENTS: One hundred forty patients with SCD and 21 healthy age-matched controls were included. Ears for each patient were divided into three groups based on computed tomography (CT) findings: 1) dehiscent, 2) thin, or 3) unaffected...
November 28, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29210943/survey-of-the-american-neurotology-society-on-cochlear-implantation-part-2-surgical-and-device-related-practice-patterns
#10
Matthew L Carlson, Brendan P O'Connell, Christine M Lohse, Colin L Driscoll, Alex D Sweeney
OBJECTIVE: To examine surgical and device-related cochlear implant practice patterns across centers in the United States. METHODS: Cross-sectional survey of the American Neurotology Society (ANS). RESULTS: A total of 81 surveys were returned from ANS members who report regular involvement in cochlear implant care. Overall there was a broad distribution in age and clinical experience, with most respondents reporting Accreditation Council for Graduate Medical Education (ACGME) accreditation in neurotology and employment at an academic center...
November 28, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29209853/3d-endoscopic-ear-surgery-a-clinical-pilot-study
#11
Daniele Bernardeschi, Ghizlene Lahlou, Daniele De Seta, Francesca Yoshie Russo, Isabelle Mosnier, Olivier Sterkers
OBJECTIVE: To evaluate the feasibility and efficacy of a new high-resolution 3D endoscope in endoscopic ear and lateral skull base surgery. METHODS: Eight patients, five women and three men, were included in this clinical pilot prospective study. Their age was 38 ± 17.3 years (mean ± SD, range 17-54 years). The right side was involved in five cases, and the left side in three cases. There were three cases of chronic otitis, one case of cholesteatoma of the external auditory canal, one case of otosclerosis, one case of cochlear implant surgery, and two cases of stage 2 vestibular schwannoma operated on with a retrosigmoid approach to preserve hearing...
December 5, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29209267/transition-from-acute-to-chronic-tinnitus-predictors-for-the-development-of-chronic-distressing-tinnitus
#12
Elisabeth Wallhäusser-Franke, Roberto D'Amelio, Anna Glauner, Wolfgang Delb, Jérôme J Servais, Karl Hörmann, Ines Repik
Background: Acute tinnitus and its transition to chronic tinnitus are poorly investigated, and factors associated with amelioration versus exacerbation are largely unknown. Aims of this study were to identify early predictors for the future development of tinnitus severity. Method: Patients with tinnitus of no longer than 4 weeks presenting at an otolaryngologist filled out questionnaires at inclusion (T1), as well as 3 (T3), and 6 months (T4) after tinnitus onset...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29208336/a-framework-for-testing-and-comparing-binaural-models
#13
Mathias Dietz, Jean-Hugues Lestang, Piotr Majdak, Richard M Stern, Torsten Marquardt, Stephan D Ewert, William M Hartmann, Dan F M Goodman
Auditory research has a rich history of combining experimental evidence with computational simulations of auditory processing in order to deepen our theoretical understanding of how sound is processed in the ears and in the brain. Despite significant progress in the amount of detail and breadth covered by auditory models, for many components of the auditory pathway there are still different model approaches that are often not equivalent but rather in conflict with each other. Similarly, some experimental studies yield conflicting results which has led to controversies...
November 28, 2017: Hearing Research
https://www.readbyqxmd.com/read/29207743/comparison-of-microbiological-flora-in-the-external-auditory-canal-of-normal-ear-and-an-ear-with-acute-otitis-externa
#14
Asheesh Dora Ghanpur, Dipak Ranjan Nayak, Kiran Chawla, V Shashidhar, Rohit Singh
Introduction: Acute Otitis Externa (AOE) is also known as swimmer's ear. Investigations initiated during World War II firmly established the role of bacteria in the aetiology of Acute Otitis Externa. Aim: To culture the microbiological flora of the normal ear and compare it with the flora causing AOE and to know the role of normal ear canal flora and anaerobes in the aetiology. Materials and Methods: A prospective observational study was conducted on 64 patients clinically diagnosed with unilateral AOE...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29207144/dner-modulates-the-length-polarity-and-synaptogenesis-of-spiral-ganglion-neurons-via-the-notch-signaling-pathway
#15
Jintao Du, Xianren Wang, Xiaobo Zhang, Xuemei Zhang, Hongyan Jiang
The Delta/Notch‑like epidermal growth factor‑related receptor (DNER) serves an important role in the developing central nervous system. However, the actions of DNER in the development of the spiral ganglion in the inner ear have yet to be elucidated. Wild‑type C57BL/6 mice were housed and time‑mated for use in the present study. Primary neuronal cultures were prepared using spiral ganglion progenitors isolated from the modiolus of postnatal day 1 (P1) mice. DNER recombinant lentiviral vectors were constructed and transfected into the cultured primary neurons...
November 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29205326/clinical-features-familial-history-and-migraine-precursors-in-patients-with-definite-vestibular-migraine-the-vm-phenotypes-projects
#16
Roberto Teggi, Bruno Colombo, Roberto Albera, Giacinto Asprella Libonati, Cristiano Balzanelli, Angel Batuecas Caletrio, Augusto Casani, Juan Manuel Espinoza-Sanchez, Paolo Gamba, Jose A Lopez-Escamez, Sergio Lucisano, Marco Mandalà, Giampiero Neri, Daniele Nuti, Rudy Pecci, Antonio Russo, Eduardo Martin-Sanz, Ricardo Sanz, Gioacchino Tedeschi, Paola Torelli, Paolo Vannucchi, Giancarlo Comi, Mario Bussi
OBJECTIVE: The aim of this work was to assess through a questionnaire the features of vertiginous episodes, accompanying symptoms, familial history, and migraine precursors in a sample of 252 subjects with a diagnosis of definite vestibular migraine. BACKGROUND: Migraine is a common neurological disorder characterized by episodic headaches with specific features. About two-thirds of cases run in families, and patients may refer symptoms occurring in infancy and childhood, defined as episodic syndromes that may be associated with migraine...
December 4, 2017: Headache
https://www.readbyqxmd.com/read/29202753/development-of-triptolide-nanoemulsion-gels-for-percutaneous-administration-physicochemical-transport-pharmacokinetic-and-pharmacodynamic-characteristics
#17
Meng Yang, Yongwei Gu, Dishun Yang, Xiaomeng Tang, Jiyong Liu
BACKGROUND: This work aimed to provide useful information on the use of nanoemulsions for the percutaneous administration of triptolide. Lipid nanosystems have great potential for transdermal drug delivery. Nanoemulsions and nanoemulsion gels were prepared to enhance percutaneous permeation. Microstructure and in vitro/in vivo percutaneous delivery characteristics of triptolide (TPL)-nanoemulsions and TPL-nanoemulsion gels were compared. The integrity of the nanoemulsions and nanoemulsion gels during transdermal delivery and its effects on the surface of skin were also investigated...
December 4, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29201646/laser-scanning-laser-diode-photoacoustic-microscopy-system
#18
Mohsen Erfanzadeh, Patrick D Kumavor, Quing Zhu
The development of low-cost and fast photoacoustic microscopy systems enhances the clinical applicability of photoacoustic imaging systems. To this end, we present a laser scanning laser diode-based photoacoustic microscopy system. In this system, a 905 nm, 325 W maximum output peak power pulsed laser diode with 50 ns pulsewidth is utilized as the light source. A combination of aspheric and cylindrical lenses is used for collimation of the laser diode beam. Two galvanometer scanning mirrors steer the beam across a focusing aspheric lens...
March 2018: Photoacoustics
https://www.readbyqxmd.com/read/29201333/development-of-the-arabic-voice-pathology-database-and-its-evaluation-by-using-speech-features-and-machine-learning-algorithms
#19
Tamer A Mesallam, Mohamed Farahat, Khalid H Malki, Mansour Alsulaiman, Zulfiqar Ali, Ahmed Al-Nasheri, Ghulam Muhammad
A voice disorder database is an essential element in doing research on automatic voice disorder detection and classification. Ethnicity affects the voice characteristics of a person, and so it is necessary to develop a database by collecting the voice samples of the targeted ethnic group. This will enhance the chances of arriving at a global solution for the accurate and reliable diagnosis of voice disorders by understanding the characteristics of a local group. Motivated by such idea, an Arabic voice pathology database (AVPD) is designed and developed in this study by recording three vowels, running speech, and isolated words...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29198719/multiethnic-gwas-reveals-polygenic-architecture-of-earlobe-attachment
#20
John R Shaffer, Jinxi Li, Myoung Keun Lee, Jasmien Roosenboom, Ekaterina Orlova, Kaustabh Adhikari, Carla Gallo, Giovanni Poletti, Lavinia Schuler-Faccini, Maria-Cátira Bortolini, Samuel Canizales-Quinteros, Francisco Rothhammer, Gabriel Bedoya, Rolando González-José, Paige E Pfeffer, Christopher A Wollenschlaeger, Jacqueline T Hecht, George L Wehby, Lina M Moreno, Anan Ding, Li Jin, Yajun Yang, Jenna C Carlson, Elizabeth J Leslie, Eleanor Feingold, Mary L Marazita, David A Hinds, Timothy C Cox, Sijia Wang, Andrés Ruiz-Linares, Seth M Weinberg
The genetic basis of earlobe attachment has been a matter of debate since the early 20th century, such that geneticists argue both for and against polygenic inheritance. Recent genetic studies have identified a few loci associated with the trait, but large-scale analyses are still lacking. Here, we performed a genome-wide association study of lobe attachment in a multiethnic sample of 74,660 individuals from four cohorts (three with the trait scored by an expert rater and one with the trait self-reported). Meta-analysis of the three expert-rater-scored cohorts revealed six associated loci harboring numerous candidate genes, including EDAR, SP5, MRPS22, ADGRG6 (GPR126), KIAA1217, and PAX9...
November 21, 2017: American Journal of Human Genetics
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