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https://www.readbyqxmd.com/read/29667301/the-feasibility-of-using-the-brighthearts-biofeedback-assisted-relaxation-application-for-the-management-of-pediatric-procedural-pain-a-pilot-study
#1
Karen L O Burton, Angela M Morrow, Brooke V Beswick, George P Khut
OBJECTIVE: The objective of this pilot study was to assess the acceptability and feasibility of using BrightHearts, a biofeedback-assisted relaxation application (app), in children undergoing painful procedures. METHODS: Thirty children 7 to 18 years of age undergoing a medical procedure (peripheral blood collection, botulinum toxin injection, or intravenous cannula insertion) participated. Participants used BrightHearts, a heart rate-controlled biofeedback-assisted relaxation training app delivered via an iPad with heart rate measured through a pulse oximeter worn on the ear or thumb...
April 17, 2018: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29665318/assessment-of-vestibular-function-in-patients-with-chronic-middle-ear-disease-using-the-vhit-and-vemp-test
#2
J S Sandhu, M Yung, J Parker-George, B Kearney, J Ray
It is widely accepted that middle ear pathology can cause dizziness and imbalance, however this has been a challenging area to investigate, as the bi-thermal caloric test is difficult to interpret in this cohort. Recently vestibular tests that bypass the middle ear have been developed. These are the Video Head Impulse Test (vHIT) and the Bone Conduction Vestibular Evoked Myogenic Potentials (BC-VEMPs). We have successfully carried out pre-operative vHIT and BC-VEMPs on 20 patients awaiting surgery for middle ear pathologies and have shown that complete testing can be done in less than 30 minutes...
April 17, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29664869/vestibular-manifestations-in-subjects-with-enlarged-vestibular-aqueduct
#3
Jae-Jin Song, Sung Kwang Hong, Sang Yeon Lee, Sung Joon Park, Seong Il Kang, Yong-Hwi An, Jeong Hun Jang, Ji Soo Kim, Ja-Won Koo
OBJECTIVE: To describe the results of a thorough evaluation in a large series of patients with an enlarged vestibular aqueduct (EVA), focusing on vestibular manifestations with etiological considerations. STUDY DESIGN: Retrospective chart review of patients with EVA. SETTING: Tertiary referral center. PATIENTS: A total of 22 EVA patients with a median age of 8 years (6 mo-35 yr) who underwent both audiovestibular and radiologic examinations...
April 16, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29664727/open-fit-domes-and-children-with-bilateral-high-frequency-sensorineural-hearing-loss-benefits-and-outcomes
#4
Patti M Johnstone, Kelly R Yeager, Marnie L Pomeroy, Nicole Hawk
BACKGROUND: Open-fit domes (OFDs) coupled with behind-the-ear (BTE) hearing aids were designed for adult listeners with moderate-to-severe bilateral high-frequency hearing loss (BHFL) with little to no concurrent loss in the lower frequencies. Adult research shows that BHFL degrades sound localization accuracy (SLA) and that BTE hearing aids with conventional earmolds (CEs) make matters worse. In contrast, research has shown that OFDs enhance spatial hearing percepts in adults with BHFL...
April 2018: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/29664721/effect-of-adaptive-compression-and-fast-acting-wdrc-strategies-on-sentence-recognition-in-noise-in-mandarin-speaking-pediatric-hearing-aid-users
#5
Haihong Liu, Yuanhu Liu, Ying Li, Xin Jin, Jing Li, Yi Zhou, Wentong Ge, Xin Ni
BACKGROUND: Wide dynamic range compression (WDRC) has been widely used in hearing aid technology. However, several reports indicate that WDRC may improve audibility at the expense of speech intelligibility. As such, a modified amplification compression scheme, named adaptive compression, was developed. However, the effect of compression strategies on speech perception in pediatric hearing aid users has not been clearly reported. PURPOSE: The purpose of the present study was to investigate the effect of adaptive compression and fast-acting WDRC processing strategies on sentence recognition in noise with Mandarin, pediatric hearing aid users...
April 2018: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/29662441/characterization-of-hair-cell-like-cells-converted-from-supporting-cells-after-notch-inhibition-in-cultures-of-the-organ-of-corti-from-neonatal-gerbils
#6
Yi Li, Shuping Jia, Huizhan Liu, Tomoko Tateya, Weiwei Guo, Shiming Yang, Kirk W Beisel, David Z Z He
The senses of hearing and balance depend upon hair cells, the sensory receptors of the inner ear. Hair cells transduce mechanical stimuli into electrical activity. Loss of hair cells as a result of aging or exposure to noise and ototoxic drugs is the major cause of noncongenital hearing and balance deficits. In the ear of non-mammals, lost hair cells can spontaneously be replaced by production of new hair cells from conversion of supporting cells. Although supporting cells in adult mammals have lost that capability, neonatal supporting cells are able to convert to hair cells after inhibition of Notch signaling...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29661534/a-new-chlorin-formulation-promotes-efficient-photodynamic-action-in-choriocapillaris-of-rabbit-s-eyes
#7
Gustavo H A Salomao, Adjaci U Fernandes, Mauricio S Baptista, João Paulo Tardivo, Stella Gianssante, Juliana Mora Veridiano, Olga Maria S Toledo, Giuliana Petri, Denise Maria Christofolini, João Antonio Correa
Age-related macular degeneration (AMD) as well as other choroidal diseases, demand novel therapeutic methods. Photodynamic therapy (PDT), which uses light and photosensitizer (PS) to cause specific vascular occlusion in the macula, is an interesting alternative. The only drug approved for the PDT treatment of AMD (Verteporfin) has a natural tendency to aggregate, demanding an expensive separation procedure during purification. We report a novel and affordable PS that is intrinsically protected against aggregation, the Monomeric Chlorin at High Concentration (MCHC-Chlorin), whose liposomal formulation was developed to provoke effective photodynamic action on the choroidal vasculature...
April 4, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29659300/otic-drug-delivery-systems-formulation-principles-and-recent-developments
#8
Xu Liu, Mingshuang Li, Hugh Smyth, Feng Zhang
Disorders of the ear severely impact the quality of life of millions of people, but the treatment of these disorders is an on-going but often overlooked challenge particularly in terms of formulation design and product development. The prevalence of ear disorders has spurred significant efforts to develop new therapeutic agents, but perhaps less innovation has been applied to new drug delivery systems to improve the efficacy of ear disease treatments. This review provides a brief overview of physiology, major diseases, and current therapies used via the otic route of administration...
April 16, 2018: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29657930/establishment-and-development-of-the-first-biobank-of-inflammatory-bowel-disease-suspected-to-primary-immunodeficiency-diseases-in-iran
#9
Roya Sherkat, Soodabeh Rostami, Majid Yaran, Mohammad Hassan Emami, Hosein Saneian, Hamid Tavakoli, Peyman Adibi, Mahdieh Behnam, Saba Sheykhbahaei, Bahram Bagherpour, Razieh Khoshnevisan, Somayeh Najafi
Background: Inflammatory bowel disease (IBD) might be an immunodeficiency rather than an excessive inflammatory reaction. IBD, suspected to primary immunodeficiency diseases biobank (IBDSPIDB) as a resource for researches can help improve the prevention, diagnosis, and illness treatment and the health promotion throughout the society. Therefore, we launched the biobank of IBDSPID for the first time in Iran. Materials and Methods: This study was designed to provide the IBDSPIDB to have a high-quality DNA, RNA, and cDNA...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29652578/mr-imaging-of-the-fetal-face-comprehensive-review
#10
Murali Nagarajan, Kedar G Sharbidre, Sudeep H Bhabad, Sharon E Byrd
The human face is a complex anatomic structure with an equally complex embryologic development. Derangement of the developmental process can result in various structural anomalies, which range from a mainly cosmetic deformity, such as cleft lip, to potentially life-threatening conditions such as arhinia. These anomalies (a) can occur as isolated anomalies; (b) can be associated with intracranial, spinal, or dental anomalies; or (c) can be a part of various syndromes, thus serving as diagnostic clues in such cases...
April 13, 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29651362/permanent-unilateral-hearing-loss-uhl-and-childhood-development
#11
REVIEW
Judith E C Lieu
Purpose of Review: The aim of this study is to summarize the consequences of permanent unilateral hearing loss (UHL) on the development of children as documented in the recent literature. Recent Findings: Congenital and early-identified UHL places young children at risk for delays in speech-language development. School-aged children with UHL score lower on standardized tests of language and cognition and need increased assistance in school for educational and behavioral issues than siblings with normal hearing, and report lower hearing-related quality of life, similar to children with bilateral hearing loss (HL)...
2018: Current Otorhinolaryngology Reports
https://www.readbyqxmd.com/read/29649793/long-term-effects-of-middle-ear-tendon-resection-on-middle-ear-myoclonic-tinnitus-hearing-and-hyperacusis
#12
Dong-Kee Kim, Jung Mee Park, Jung Ju Han, Yun Min Chung, Jung Min Kim, So Young Park, Shi Nae Park
OBJECTIVE: To evaluate the therapeutic effects of middle ear tendon resection (METR) on middle ear myoclonic tinnitus (MEMT) and to investigate its long-term effects on hearing and hyperacusis. MATERIALS AND METHODS: Thirty-seven patients with MEMT with a mean age of 33.2 ± 11.8 years were included in this study. METR was performed on all 37 MEMT patients (41 ears) between November 2004 and August 2016. The mean follow-up period was 16.1 months. We examined changes in tinnitus and accompanying stress and depression in patients after surgery, and examined the hearing changes and the occurrence of complications including hyperacusis...
April 12, 2018: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/29649047/preliminary-outcomes-report-for-co2-laser-assisted-electric-acoustic-cochlear-implantation
#13
Shawn M Stevens, Andrew Redmann, Kayla Whitaker, Alyson Ruotanen, Lisa Houston, Theresa Hammer, Ravi N Samy
OBJECTIVE: Report on the safety/efficacy of a novel, carbon dioxide (CO2) laser-assisted protocol for hearing-preservation cochlear implantation (HPCI) and electric-acoustic stimulation (EAS). STUDY DESIGN: Retrospective case review. SETTING: Tertiary referral center. PATIENTS: Adult patients meeting established criteria for HPCI and EAS. INTERVENTION: Therapeutic/rehabilitative. A standardized protocol used CO2 laser to achieve meticulous hemostasis and perform cochleostomy was evaluated...
April 11, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29642738/rats-and-rabbits-as-pharmacokinetic-screening-tools-for-long-acting-intramuscular-depots-case-study-with-paliperidone-palmitate-suspension
#14
Harilal Patel, Prakash Patel, Nirav Modi, Pinakin Patel, Yogesh Wagh, Alex George, Nirmal Desai, Nuggehally R Srinivas
1. Development of prodrug of paliperidone (9-hydroxyrisperidone) long-acting intramuscular injection has enabled delivery over 4-week time period with improved compliance. 2. Key aim of work was to establish a reliable preclinical model which may potentially serve as a screening tool for judging the pharmacokinetics of paliperidone formulation(s) prior to human clinical work. 3. Sparse sampling composite study was used in rats, (Wistar/Sprague-Dawley (n = 10)). A serial blood sampling study design was used in rabbits (n = 4)...
April 12, 2018: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29628872/excitation-of-the-auditory-system-as-a-result-of-non-invasive-extra-cochlear-stimulation-in-normal-subjects-and-tinnitus-patients
#15
Marzena Mielczarek, Arnaud Norena, Winfried Schlee, Jurek Olszewski
One of possible approach that may suppress tinnitus is electrical stimulation of the ear. At first invasive techniques were used (promontory or round window stimulation), nowadays a non-invasive method, namely hydrotransmissive electric stimulation (ES) through external acoustic canal, has been developed. The aim of the study is to investigate the effect of applying ES with positive and negative current polarities on the ears of healthy subjects and on the tinnitus ears of patients with tinnitus. This comparison further clarifies the mechanisms of operation of non-invasive extra-cochlear ear ES...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29624914/fragile-x-checklists-a-meta-analysis-and-development-of-a-simplified-universal-clinical-checklist
#16
Toni Kasole Lubala, Aimé Lumaka, Gray Kanteng, Léon Mutesa, Olivier Mukuku, Stanislas Wembonyama, Randi Hagerman, Oscar Numbi Luboya, Prosper Lukusa Tshilobo
BACKGROUND: Clinical checklists available have been developed to assess the risk of a positive Fragile X syndrome but they include relatively small sample sizes. Therefore, we carried out a meta-analysis that included statistical pooling of study results to obtain accurate figures on the prevalence of clinical predictors of Fragile X syndrome among patients with intellectual disability, thereby helping health professionals to improve their referrals for Fragile X testing. METHODS: All published studies consisting of cytogenetic and/or molecular screening for fragile X syndrome among patients with intellectual disability, were eligible for the meta-analysis...
April 6, 2018: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29624209/withdrawn-grommets-ventilation-tubes-for-recurrent-acute-otitis-media-in-children
#17
REVIEW
Loretta Lau, Paul Mick, Desmond A Nunez
BACKGROUND: This is an update of a Cochrane review first published in The Cochrane Library in Issue 4, 2008 and previously updated in 2011.Acute suppurative otitis media is one of the most common infectious diseases in childhood. Recurrent acute otitis media is defined for the purposes of this review as either three or more acute infections of the middle ear cleft in a six-month period, or at least four episodes in a year. Strategies for managing the condition include the assessment and modification of risk factors where possible, repeated courses of antibiotics for each new infection, antibiotic prophylaxis and the insertion of ventilation tubes (grommets)...
April 6, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29621286/expert-guided-optimization-for-3d-printing-of-soft-and-liquid-materials
#18
Sara Abdollahi, Alexander Davis, John H Miller, Adam W Feinberg
Additive manufacturing (AM) has rapidly emerged as a disruptive technology to build mechanical parts, enabling increased design complexity, low-cost customization and an ever-increasing range of materials. Yet these capabilities have also created an immense challenge in optimizing the large number of process parameters in order achieve a high-performance part. This is especially true for AM of soft, deformable materials and for liquid-like resins that require experimental printing methods. Here, we developed an expert-guided optimization (EGO) strategy to provide structure in exploring and improving the 3D printing of liquid polydimethylsiloxane (PDMS) elastomer resin...
2018: PloS One
https://www.readbyqxmd.com/read/29619494/a-giant-tonsillolith
#19
Abdulrhman Alfayez, Meshal B Albesher, Mohammed A Alqabasani
Tonsillar stones are the products of calcified accumulates of cellular debris and microorganisms, in the crypts of palatine tonsils. Tonsillar stones are common findings and the known cause of bad breath (halitosis). Development of large tonsillar stones, however, is rare with only a few cases reported in the literature. We present the case of a 45-year-old man with a history of recurrent sore throat and tonsillitis for a long period, and snoring with other unremarkable ears, nose and throat findings. A large-sized tonsillar stone detected in the left tonsil measured 3...
April 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29619096/development-and-administration-of-chronic-suppurative-otitis-media-questionnaire-12-comq-12-and-chronic-otitis-media-outcome-test-15-comot-15-in-kannada
#20
Prashanth Prabhu, Anusha Chandrashekar, Anita Jose, Aishwarya Ganeshan, Lavanya Kiruthika
Introduction  It is essential to determine the quality of life among individuals with chronic suppurative otitis media (CSOM). However, there is limited literature on health-related quality of life measurements in Kannada-speaking individuals with CSOM. Objectives  The present study attempted to translate and validate Chronic Suppurative Otitis Media Questionnaire-12 (COMQ-12) and Chronic Otitis Media Outcome Test-15 (COMOT-15) in Kannada. Method  The English questionnaires were translated and back-translated, and they were later verified for content validity...
April 2018: International Archives of Otorhinolaryngology
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