Ziyi Liu, Hanbing Zhang, Guodong Hong, Xiuli Bi, Jun Hu, Tiancheng Zhang, Yachun An, Na Guo, Fengyue Dong, Yu Xiao, Wen Li, Xiaoxu Zhao, Bo Chu, Siwei Guo, Xiaohan Zhang, Renjie Chai, Xiaolong Fu
Cisplatin-induced hearing loss is a common side effect of cancer chemotherapy in clinics, however, the mechanism of cisplatin-induced ototoxicity is still not completely clarified. Cisplatin-induced ototoxicity is mainly associated with the production of reactive oxygen species, activation of apoptosis, and accumulation of intracellular lipid peroxidation, which also is involved in ferroptosis induction. In this study, the expression of TfR1, a ferroptosis biomarker, was upregulated in the outer hair cells of cisplatin-treated mice...
February 26, 2024: Molecular Therapy