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Four pillar

Giovanni De Feo, Sabino De Gisi, Sabato De Vita, Michele Notarnicola
The main aim of this study was to define and apply a multidisciplinary and multi-criteria approach to sustainability in evaluating alternative end-uses for disused areas. Taking into account the three pillars of sustainability (social, economic and environmental dimension) as well as the need for stakeholders to have new practical instruments, the innovative approach consists of four modules stated (i) sociological, (ii) economic, (iii) environmental and (iv) multi-criteria assessment. By means of a case study on a small Municipality in Southern Italy, three end-uses alternatives, representing three essential services for citizens, were selected: Municipal gym; Market area; Municipal Solid Waste (MSW) separate collection centre...
March 7, 2018: Science of the Total Environment
A Odone, B Roberts, M Dara, M van den Boom, H Kluge, M McKee
SETTING: The first pillar in the World Health Organisation's (WHO's) End TB strategy is 'Integrated, patient-centred tuberculosis (TB) care and prevention'. However, what are patient- and people-centred care, and why are they important for TB care and prevention? OBJECTIVE AND RATIONALE: To define the concept of patient-centred care, the rationale for it, and its evolution into people-centred care; and to explore evidence on whether people-centred approaches work for TB and present key areas where continuous efforts are needed to support their implementation...
February 1, 2018: International Journal of Tuberculosis and Lung Disease
Yuchi Zhang, Yuanhua Wu, Xin He, Junhan Ma, Xuan Shen, Dunru Zhu
Using polynuclear metal clusters as nodes, many high-symmetry high-connectivity nets, like 8-connnected bcu and 12-connected fcu, have been attained in metal-organic frameworks (MOFs). However, construction of low-symmetry high-connected MOFs with a novel topology still remains a big challenge. For example, a uninodal 8-connected lsz network, observed in inorganic ZrSiO4 , has not been topologically identified in MOFs. Using 2,2'-difluorobiphenyl-4,4'-dicarboxylic acid (H2 L) as a new linker and 1,2,4-triazole (Htrz) as a coligand, a novel three-dimensional CdII -MOF, namely poly[tetrakis(μ4 -2,2'-difluorobiphenyl-4,4'-dicarboxylato-κ5 O1 ,O1' :O1' :O4 :O4' )tetrakis(N,N-dimethylformamide-κO)tetrakis(μ3 -1,2,4-triazolato-κ3 N1 :N2 :N4 )hexacadmium(II)], [Cd6 (C14 H6 F2 O4 )4 (C2 H2 N3 )4 (C3 H7 NO)4 ]n , (I), has been prepared...
March 1, 2018: Acta Crystallographica. Section C, Structural Chemistry
Lin-Quan Tang, Dong-Ping Chen, Ling Guo, Hao-Yuan Mo, Ying Huang, Shan-Shan Guo, Bin Qi, Qing-Nan Tang, Pan Wang, Xiao-Yun Li, Ji-Bin Li, Qing Liu, Yuan-Hong Gao, Fang-Yun Xie, Li-Ting Liu, Yang Li, Sai-Lan Liu, Hao-Jun Xie, Yu-Jing Liang, Xue-Song Sun, Jin-Jie Yan, Yi-Shan Wu, Dong-Hua Luo, Pei-Yu Huang, Yan-Qun Xiang, Rui Sun, Ming-Yuan Chen, Xing Lv, Lin Wang, Wei-Xiong Xia, Chong Zhao, Ka-Jia Cao, Chao-Nan Qian, Xiang Guo, Ming-Huang Hong, Zhi-Qiang Nie, Qiu-Yan Chen, Hai-Qiang Mai
BACKGROUND: Cisplatin-based concurrent chemoradiotherapy is currently considered to be the standard treatment regimen for patients with advanced nasopharyngeal carcinoma, but has well known side-effects such as gastrointestinal reactions, nephrotoxicity, and ototoxicity. Nedaplatin was developed to decrease the toxic effects induced by cisplatin, and in this trial we assessed whether a nedaplatin-based concurrent chemoradiotherapy regimen was non-inferior to a cisplatin-based regimen in patients with locoregional, stage II-IVB nasopharyngeal carcinoma...
February 28, 2018: Lancet Oncology
Dorota Szcześniak, Rose-Marie Dröes, Franka Meiland, Dawn Brooker, Elisabetta Farina, Rabih Chattat, Shirley B Evans, Simon C Evans, Francesca Lea Saibene, Katarzyna Urbańska, Joanna Rymaszewska
BACKGROUND: The "pathway to care" concept offers a helpful framework for preparing national dementia plans and strategies and provides a structure to explore the availability and accessibility of timely and effective care for people with dementia and support for their informal carers. Within the framework of the JPND-MEETINGDEM implementation project the pathways to regular day-care activities and the Meeting Centers Support Programme (MCSP), an innovative combined support form for people with dementia and carers, was explored...
February 13, 2018: International Psychogeriatrics
Yu-Jie Wang, Yang-Yang Zhou, Hong-Guo Hao, Man Song, Na Zhang, Shuang Yao, Jing-Hui Yan, Zhi-Ming Zhang, Tong-Bu Lu
Two robust metal-organic frameworks (MOFs), {H4[Ni(π-H2O)2]2[Ni(rt-H2O)2]8Ni4(Tri)24}[VIVW12O40]2·24H2O (1) and {H[Ni(π-O)2]2[Ni(rt-H2O)2]8Ni4(Tri)24}[VIVW10VV2O40V2][VIVW9VV3O40VIV2]·24H2O (2) (Tri = 1,2,4-triazole), composed of polyoxometalates (POMs) and metal-organic units, were designed and synthesized by a hydrothermal method. Structure analysis indicates that there is a metal-organic crown [{Ni3(Tri)6(H2O)4}4] ({Ni12}) in these two compounds. In 1, the {Ni12} crown embraces four pendant Tri ligands that could capture a cationic [Ni(H2O)2]2+ group, resulting in the Ni13-Tri building unit [Ni(H2O)2{Ni3(Tri)6(H2O)4}4] ({Ni13})...
January 18, 2018: Inorganic Chemistry
Jessica D Schaefer, John M Welton
AIM: To analyse and define the concept "evidence based practice readiness" in nurses. BACKGROUND: Evidence based practice readiness is a term commonly used in health literature, but without a clear understanding of what readiness means. Concept analysis is needed to define the meaning of evidence based practice readiness. METHOD: A concept analysis was conducted using Walker and Avant's method to clarify the defining attributes of evidence based practice readiness as well as antecedents and consequences...
January 15, 2018: Journal of Nursing Management
Hyunjun Cho, Shailabh Kumar, Daejong Yang, Sagar R Vaidyanathan, Kelly Woo, Ian Garcia, Hao Jan Shue, Youngzoon Yoon, Kevin Ferreri, Hyuck Choo
Label-free optical detection of insulin would allow in vitro assessment of pancreatic cell functions in their natural state and expedite diabetes-related clinical research and treatment, however no existing method has met these criteria at physiological concentrations. Using spatially-uniform 3D gold-nanoparticle sensors, we have demonstrated surface-enhanced Raman sensing of insulin in the secretions from human pancreatic islets under low and high glucose environments without the use of labels such as antibodies or aptamers...
January 11, 2018: ACS Sensors
Can Ince
This paper introduces the concept of personalized physiological medicine that is specifically directed at the needs of the critically ill patient. This differs from the conventional view of personalized medicine, characterized by biomarkers and gene profiling, instead focusing on time-variant changes in the pathophysiology and regulation of various organ systems and their cellular and subcellular constituents. I propose that personalized physiological medicine is composed of four pillars relevant to the critically ill patient...
December 28, 2017: Critical Care: the Official Journal of the Critical Care Forum
Chenlu Li, Yongmei Lu, Jianing Liu, Xiaoxu Wu
Dengue Fever (DF) has become one of the most serious infectious diseases in China. Dengue virus and its vector (Aedes mosquito) are known to be sensitive to climate condition. Climate impacts DF through affecting three essential bioecological aspects: DF virus, vector (mosquito) and DF transmission environment. Weather-based DF model, mosquito model and climate model are the three pillars to help the prediction of DF distribution. Through a systematic review of literature between 1980 and 2017, this paper summarizes empirical evidences in China on the impact of climate change on DF; it further reviews the related DF incidence models and their findings on how changes in weather factors may impact DF occurrences in China...
May 1, 2018: Science of the Total Environment
Minjie Guo, Xuemei Wang, Caihong Zhan, Paul Demay-Drouhard, Wenjiao Li, Ke Du, Mark A Olson, Han Zuilhof, Andrew C-H Sue
The synthesis of "rim-differentiated" C5 -symmetric pillar[5]arenes, whose two rims are decorated with different chemical functionalities, has remained a challenging task. This is due to the inherent statistical nature of the cyclization of 1,4-disubstituted alkoxybenzenes with different substituents, which leads to four constitutional isomers with only 1/16th being rim-differentiated. Herein, we report a "preoriented" synthetic protocol based on FeCl3 -catalyzed cyclization of asymmetrically substituted 2,5-dialkoxybenzyl alcohols...
January 10, 2018: Journal of the American Chemical Society
Ling Ding, Le-Hui Liu, Qing Shi, Yan-Qiong Sun, Yong-Jiang Wang, Yi-Ping Chen
Four novel three-dimensional (3D) 4d-4f heterometal-organic compounds, [LnCd2 (Pbc)4 (Meimdc)(H2 O)]·3H2 O (Ln = Eu, 1a; Tb, 1b; Sm, 1c; Dy, 1d) (HPbc = 4-(4-pyridinyl)benzoic acid; H3 Meimdc = 2-methyl-1H-4,5-imidazole-dicarboxylic acid), have been successfully prepared by a hydrothermal method. All the compounds are isostructural and show three-dimensional microporous pillar-layered structures with uncoordinated carboxylate sites hung in the channels. Compound 1a possesses excellent chemical stability. The luminescent investigations show that compounds 1a, 1b, 1c, and 1d display the characteristic emission bands of Ln3+ ions...
December 18, 2017: Inorganic Chemistry
Robert L Schalock, Miguel Angel Verdugo, Jos van Loon
Organization transformation is an increasingly important concept and process in human service organizations as they adapt to rapidly changing challenges and opportunities to enhance their effectiveness, efficiency, and sustainability. This article describes a four-component organization transformation model that incorporates transformation pillars, transformation strategies, organization capacity, and organization outputs and outcomes. The article includes examples of the model's use, and concludes with a discussion of valuable lessons learned to date...
April 2018: Evaluation and Program Planning
Greig Craft, Truong Van Bui, Mirjam Sidik, Danielle Moore, David J Ederer, Erin M Parker, Michael F Ballesteros, David A Sleet
Motorcyclists account for 23% of global road traffic deaths and over half of fatalities in countries where motorcycles are the dominant means of transport. Wearing a helmet can reduce the risk of head injury by as much as 69% and death by 42%; however, both child and adult helmet use are low in many countries where motorcycles are a primary mode of transportation. In response to the need to increase helmet use by all drivers and their passengers, the Global Helmet Vaccine Initiative (GHVI) was established to increase helmet use in three countries where a substantial portion of road users are motorcyclists and where helmet use is low...
November 30, 2017: International Journal of Environmental Research and Public Health
Helir-Joseph Muñoz, Carolina Blanco, Antonio Gil, Miguel-Ángel Vicente, Luis-Alejandro Galeano
Four natural clays were modified with mixed polyoxocations of Al/Fe for evaluating the effect of the physicochemical properties of the starting materials (chemical composition, abundance of expandable clay phases, cationic exchange capacity and textural properties) on final physicochemical and catalytic properties of Al/Fe-PILCs. The aluminosilicate denoted C2 exhibited the highest potential as starting material in the preparation of Al/Fe-PILC catalysts, mainly due to its starting cationic exchange capacity (192 meq/100 g) and the dioctahedral nature of the smectite phase...
November 28, 2017: Materials
Maria Eugenia Roca Jalil, Miria Baschini, Karim Sapag
Emerging contaminants in the environment have caused enormous concern in the last few decades, and among them, antibiotics have received special attention. On the other hand, adsorption has shown to be a useful, low-cost, and eco-friendly method for the removal of this type of contaminants from water. This work is focused on the study of ciprofloxacin (CPX) removal from water by adsorption on pillared clays (PILC) under basic pH conditions, where CPX is in its anionic form (CPX(-)). Four different materials were synthetized, characterized, and studied as adsorbents of CPX (Al-, Fe-, Si-, and Zr-PILC)...
November 23, 2017: Materials
D Elias Jesu Packiam, Kanamaluru Vidyasagar
Twenty new molybdenum phosphonates and diphosphonates have been synthesized and structurally characterized by single crystal and powder X-ray diffraction, CHN analyses, spectroscopic and thermal studies. Four of them are molecular phenyl- and benzyl-phosphonates containing discrete [(MoO3 )5 (O3 PR)2 ]4- (R = Ph or CH2 Ph) cyclic anions. The sixteen non-molecular compounds are layered isostructural phenylphosphonates, A2 [Mo2 O5 (O3 PPh)2 ] (A = NH4 , Tl, Rb, Cs) and K1.5 (H3 O)0.5 [Mo2 O5 (O3 PPh)2 ] and the corresponding diphosphonate compounds with pillared anionic layers, A2 [Mo2 O5 (O3 P(CH2 )3 PO3 )], A2 [Mo2 O5 (O3 P(CH2 )4 PO3 )] and A2 [Mo2 O5 (O3 P(C6 H4 )PO3 )]...
November 28, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
Sebastian Glomb, Dennis Woschko, Gamall Makhloufi, Christoph Janiak
Introduction of a urea R-NH-CO-NH-R group as a seven-membered diazepine ring at the center of 4,4'-biphenyl-dicarboxylic acid leads to a urea-functionalized dicarboxylate linker (L1(2-)) from which four zinc metal-organic frameworks (MOFs) could be obtained, having a {Zn4(μ4-O)(O2C-)6} SBU and IRMOF-9 topology (compound [Zn4(μ4-O)(L1)3], 1, from dimethylformamide, DMF) or a {Zn2(O2C-)4} paddle-wheel SBU in a 2D-network (compound [Zn2(L1)2(DEF)2·2.5DEF], 2, from diethylformamide, DEF). Pillaring of the 2D-network of 2 with 4,4'-bipyridine (bipy) or 1,2-bis(4-pyridyl)ethane (bpe) gives 3D frameworks with rhombohedrally distorted pcu-a topologies ([Zn2(L1)2(bipy)], 3 and [Zn2(L1)2(bpe)], 4, respectively)...
October 13, 2017: ACS Applied Materials & Interfaces
Anette E Fransson, Marta Kisiel, Kristian Pirttilä, Curt Pettersson, Pernilla Videhult Pierre, Göran F E Laurell
Introduction: Permanent hearing loss and tinnitus as side-effects from treatment with the anticancer drug cisplatin is a clinical problem. Ototoxicity may be reduced by co-administration of an otoprotective agent, but the results in humans have so far been modest. Aim: The present preclinical in vivo study aimed to explore the protective efficacy of hydrogen (H2) inhalation on ototoxicity induced by intravenous cisplatin. Materials and Methods: Albino guinea pigs were divided into four groups. The Cispt (n = 11) and Cispt+H2 (n = 11) groups were given intravenous cisplatin (8 mg/kg b...
2017: Frontiers in Cellular Neuroscience
Sanjay Kalra, Komal Verma, Yatan Pal Singh Balhara
This article discusses a comprehensive approach to the management of diabetes distress. It mentions the screening and diagnosis of diabetes distress, and discusses its etiopathogenesis, investigations and management strategies in detail. The management of diabetes distress, termed as diabetes therapy by the ear, is based upon four pillars: strengthening of self-care skills, optimization of coping skills, minimizing change-related discomfort, and utilization of external support. The article describes coping skills training and change-related discomfort mitigation in detail...
October 2017: JPMA. the Journal of the Pakistan Medical Association
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