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https://www.readbyqxmd.com/read/29334149/evidence-based-practice-readiness-a-concept-analysis
#1
Jessica D Schaefer, John M Welton
AIM: To analyse and define the concept "evidence based practice readiness" in nurses. BACKGROUND: Evidence based practice readiness is a term commonly used in health literature, but without a clear understanding of what readiness means. Concept analysis is needed to define the meaning of evidence based practice readiness. METHOD: A concept analysis was conducted using Walker and Avant's method to clarify the defining attributes of evidence based practice readiness as well as antecedents and consequences...
January 15, 2018: Journal of Nursing Management
https://www.readbyqxmd.com/read/29322773/sers-based-label-free-insulin-detection-at-physiological-concentrations-for-analysis-of-islet-performance
#2
Hyunjun Cho, Shailabh Kumar, Daejong Yang, Sagar R Vaidyanathan, Kelly Woo, Ian Garcia, Hao Jan Shue, Youngzoon Yoon, Kevin Ferreri, Hyuck Choo
Label-free optical detection of insulin would allow in vitro assessment of pancreatic cell functions in their natural state and expedite diabetes-related clinical research and treatment, however no existing method has met these criteria at physiological concentrations. Using spatially-uniform 3D gold-nanoparticle sensors, we have demonstrated surface-enhanced Raman sensing of insulin in the secretions from human pancreatic islets under low and high glucose environments without the use of labels such as antibodies or aptamers...
January 11, 2018: ACS Sensors
https://www.readbyqxmd.com/read/29297391/personalized-physiological-medicine
#3
REVIEW
Can Ince
This paper introduces the concept of personalized physiological medicine that is specifically directed at the needs of the critically ill patient. This differs from the conventional view of personalized medicine, characterized by biomarkers and gene profiling, instead focusing on time-variant changes in the pathophysiology and regulation of various organ systems and their cellular and subcellular constituents. I propose that personalized physiological medicine is composed of four pillars relevant to the critically ill patient...
December 28, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29220773/climate-change-and-dengue-fever-transmission-in-china-evidences-and-challenges
#4
REVIEW
Chenlu Li, Yongmei Lu, Jianing Liu, Xiaoxu Wu
Dengue Fever (DF) has become one of the most serious infectious diseases in China. Dengue virus and its vector (Aedes mosquito) are known to be sensitive to climate condition. Climate impacts DF through affecting three essential bioecological aspects: DF virus, vector (mosquito) and DF transmission environment. Weather-based DF model, mosquito model and climate model are the three pillars to help the prediction of DF distribution. Through a systematic review of literature between 1980 and 2017, this paper summarizes empirical evidences in China on the impact of climate change on DF; it further reviews the related DF incidence models and their findings on how changes in weather factors may impact DF occurrences in China...
December 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29220153/rim-differentiated-c5-symmetric-tiara-pillar-5-arenes
#5
Minjie Guo, Xuemei Wang, Caihong Zhan, Paul Demay-Drouhard, Wenjiao Li, Ke Du, Mark A Olson, Han Zuilhof, Andrew Chi-Hau Sue
The synthesis of "rim-differentiated" C5-symmetric pillar[5]arenes, whose two rims are decorated with different chemical functionalities, has remained a challenging task. This is due to the inherent statistical nature of the cyclization of 1,4-disubstituted alkoxybenzenes with different substituents, which leads to four constitutional isomers with only 1/16th being rim-differentiated. Herein, we report a "pre-oriented" synthetic protocol based on FeCl3-catalyzed cyclization of asymmetrically-substituted 2,5-dialkoxybenzyl alcohols...
December 8, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29199826/luminescent-3d-lanthanide-cadmium-heterometal-organic-frameworks-with-chemical-stability-and-selective-luminescent-sensing
#6
Ling Ding, Le-Hui Liu, Qing Shi, Yan-Qiong Sun, Yong-Jiang Wang, Yi-Ping Chen
Four novel three-dimensional (3D) 4d-4f heterometal-organic compounds, [LnCd2(Pbc)4(Meimdc)(H2O)]·3H2O (Ln = Eu, 1a; Tb, 1b; Sm, 1c; Dy, 1d) (HPbc = 4-(4-pyridinyl)benzoic acid; H3Meimdc = 2-methyl-1H-4,5-imidazole-dicarboxylic acid), have been successfully prepared by a hydrothermal method. All the compounds are isostructural and show three-dimensional microporous pillar-layered structures with uncoordinated carboxylate sites hung in the channels. Compound 1a possesses excellent chemical stability. The luminescent investigations show that compounds 1a, 1b, 1c, and 1d display the characteristic emission bands of Ln3+ ions...
December 4, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29197716/understanding-organization-transformation-in-evaluation-and-program-planning
#7
Robert L Schalock, Miguel Angel Verdugo, Jos van Loon
Organization transformation is an increasingly important concept and process in human service organizations as they adapt to rapidly changing challenges and opportunities to enhance their effectiveness, efficiency, and sustainability. This article describes a four-component organization transformation model that incorporates transformation pillars, transformation strategies, organization capacity, and organization outputs and outcomes. The article includes examples of the model's use, and concludes with a discussion of valuable lessons learned to date...
November 24, 2017: Evaluation and Program Planning
https://www.readbyqxmd.com/read/29189764/a-comprehensive-approach-to-motorcycle-related-head-injury-prevention-experiences-from-the-field-in-vietnam-cambodia-and-uganda
#8
Greig Craft, Truong Van Bui, Mirjam Sidik, Danielle Moore, David J Ederer, Erin M Parker, Michael F Ballesteros, David A Sleet
Motorcyclists account for 23% of global road traffic deaths and over half of fatalities in countries where motorcycles are the dominant means of transport. Wearing a helmet can reduce the risk of head injury by as much as 69% and death by 42%; however, both child and adult helmet use are low in many countries where motorcycles are a primary mode of transportation. In response to the need to increase helmet use by all drivers and their passengers, the Global Helmet Vaccine Initiative (GHVI) was established to increase helmet use in three countries where a substantial portion of road users are motorcyclists and where helmet use is low...
November 30, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29182560/preparation-of-al-fe-pillared-clays-effect-of-the-starting-mineral
#9
Helir-Joseph Muñoz, Carolina Blanco, Antonio Gil, Miguel-Ángel Vicente, Luis-Alejandro Galeano
Four natural clays were modified with mixed polyoxocations of Al/Fe for evaluating the effect of the physicochemical properties of the starting materials (chemical composition, abundance of expandable clay phases, cationic exchange capacity and textural properties) on final physicochemical and catalytic properties of Al/Fe-PILCs. The aluminosilicate denoted C2 exhibited the highest potential as starting material in the preparation of Al/Fe-PILC catalysts, mainly due to its starting cationic exchange capacity (192 meq/100 g) and the dioctahedral nature of the smectite phase...
November 28, 2017: Materials
https://www.readbyqxmd.com/read/29168798/removal-of-ciprofloxacin-from-aqueous-solutions-using-pillared-clays
#10
Maria Eugenia Roca Jalil, Miria Baschini, Karim Sapag
Emerging contaminants in the environment have caused enormous concern in the last few decades, and among them, antibiotics have received special attention. On the other hand, adsorption has shown to be a useful, low-cost, and eco-friendly method for the removal of this type of contaminants from water. This work is focused on the study of ciprofloxacin (CPX) removal from water by adsorption on pillared clays (PILC) under basic pH conditions, where CPX is in its anionic form (CPX(-)). Four different materials were synthetized, characterized, and studied as adsorbents of CPX (Al-, Fe-, Si-, and Zr-PILC)...
November 23, 2017: Materials
https://www.readbyqxmd.com/read/29125165/syntheses-and-characterization-of-phosphonates-and-diphosphonates-of-molybdenum-a4-moo3-5-o3pr-2-%C3%A2-xh2o-a2-mo2o5-o3pr-2-and-a2-mo2o5-o3p-r-po3-a-k-rb-cs-tl-nh4
#11
D Elias Jesu Packiam, Kanamaluru Vidyasagar
Twenty new molybdenum phosphonates and diphosphonates have been synthesized and structurally characterized by single crystal and powder X-ray diffraction, CHN analyses, spectroscopic and thermal studies. Four of them are molecular phenyl- and benzyl-phosphonates containing discrete [(MoO3)5(O3PR)2](4-) (R = Ph or CH2Ph) cyclic anions. The sixteen non-molecular compounds are layered isostructural phenylphosphonates, A2[Mo2O5(O3PPh)2] (A = NH4, Tl, Rb, Cs) and K1.5(H3O)0.5[Mo2O5(O3PPh)2] and the corresponding diphosphonate compounds with pillared anionic layers, A2[Mo2O5(O3P(CH2)3PO3)], A2[Mo2O5(O3P(CH2)4PO3)] and A2[Mo2O5(O3P(C6H4)PO3)]...
November 10, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28976188/metal-organic-frameworks-with-internal-urea-functionalized-dicarboxylate-linkers-for-so2-and-nh3-adsorption
#12
Sebastian Glomb, Dennis Woschko, Gamall Makhloufi, Christoph Janiak
Introduction of a urea R-NH-CO-NH-R group as a seven-membered diazepine ring at the center of 4,4'-biphenyl-dicarboxylic acid leads to a urea-functionalized dicarboxylate linker (L1(2-)) from which four zinc metal-organic frameworks (MOFs) could be obtained, having a {Zn4(μ4-O)(O2C-)6} SBU and IRMOF-9 topology (compound [Zn4(μ4-O)(L1)3], 1, from dimethylformamide, DMF) or a {Zn2(O2C-)4} paddle-wheel SBU in a 2D-network (compound [Zn2(L1)2(DEF)2·2.5DEF], 2, from diethylformamide, DEF). Pillaring of the 2D-network of 2 with 4,4'-bipyridine (bipy) or 1,2-bis(4-pyridyl)ethane (bpe) gives 3D frameworks with rhombohedrally distorted pcu-a topologies ([Zn2(L1)2(bipy)], 3 and [Zn2(L1)2(bpe)], 4, respectively)...
October 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28955207/hydrogen-inhalation-protects-against-ototoxicity-induced-by-intravenous-cisplatin-in-the-guinea-pig
#13
Anette E Fransson, Marta Kisiel, Kristian Pirttilä, Curt Pettersson, Pernilla Videhult Pierre, Göran F E Laurell
Introduction: Permanent hearing loss and tinnitus as side-effects from treatment with the anticancer drug cisplatin is a clinical problem. Ototoxicity may be reduced by co-administration of an otoprotective agent, but the results in humans have so far been modest. Aim: The present preclinical in vivo study aimed to explore the protective efficacy of hydrogen (H2) inhalation on ototoxicity induced by intravenous cisplatin. Materials and Methods: Albino guinea pigs were divided into four groups. The Cispt (n = 11) and Cispt+H2 (n = 11) groups were given intravenous cisplatin (8 mg/kg b...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28955090/management-of-diabetes-distress
#14
Sanjay Kalra, Komal Verma, Yatan Pal Singh Balhara
This article discusses a comprehensive approach to the management of diabetes distress. It mentions the screening and diagnosis of diabetes distress, and discusses its etiopathogenesis, investigations and management strategies in detail. The management of diabetes distress, termed as diabetes therapy by the ear, is based upon four pillars: strengthening of self-care skills, optimization of coping skills, minimizing change-related discomfort, and utilization of external support. The article describes coping skills training and change-related discomfort mitigation in detail...
October 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28905220/haplotype-study-in-sca10-families-provides-further-evidence-for-a-common-ancestral-origin-of-the-mutation
#15
Giovana B Bampi, Rafael Bisso-Machado, Tábita Hünemeier, Tailise C Gheno, Gabriel V Furtado, Diego Veliz-Otani, Mario Cornejo-Olivas, Pillar Mazzeti, Maria Cátira Bortolini, Laura B Jardim, Maria Luiza Saraiva-Pereira
Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant neurodegenerative disorder characterized by progressive cerebellar ataxia and epilepsy. The disease is caused by a pentanucleotide ATTCT expansion in intron 9 of the ATXN10 gene on chromosome 22q13.3. SCA10 has shown a geographical distribution throughout America with a likely degree of Amerindian ancestry from different countries so far. Currently available data suggest that SCA10 mutation might have spread out early during the peopling of the Americas...
December 2017: Neuromolecular Medicine
https://www.readbyqxmd.com/read/28864723/challenges-and-opportunities-in-adapting-clinical-trial-design-for-immunotherapies
#16
EDITORIAL
Lillian L Siu, S Percy Ivy, Erica L Dixon, Amy E Gravell, Steven A Reeves, Gary L Rosner
Immunotherapy adds an exciting new dimension to the treatment of cancer, joining other approaches as a key pillar in the oncotherapeutics armamentarium. Immuno-oncology agents harbor unique mechanisms of antitumor activity by leveraging the host immune system, which may result in response patterns, resistance kinetics, and toxicity profiles that differ from other systemic therapies. These features have led to many discussions on ways to optimally integrate immunotherapy into cancer clinical trials. This overview provides an introduction to the four CCR Focus articles that ensue, with special thoughts paid to clinical trial endpoints, biomarker development and validation, combination strategies, and limitations that arise with increasing use of these agents...
September 1, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28851383/a-system-approach-to-improving-maternal-and-child-health-care-delivery-in-kenya-innovations-at-the-community-and-primary-care-facilities-a-protocol
#17
Fabian Esamai, Mabel Nangami, John Tabu, Ann Mwangi, David Ayuku, Edwin Were
BACKGROUND: Maternal, fetal and neonatal mortality are higher in low-income compared to high-income countries due to weak health systems including poor access and utilization of health services. Despite enormous recent improvements in maternal, neonatal and under 5 health indicators, more rapid progress is needed to meet the targets including the Development Goal 3(SDG). In Kenya these indicators are still high and comprehensive systems are needed to attain the targets of the SDG 3 by 2030...
August 29, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28845722/the-pillars-of-well-constructed-simulated-patient-programs-a-qualitative-study-with-experienced-educators
#18
Shane A Pritchard, Felicity C Blackstock, Jennifer L Keating, Debra Nestel
INTRODUCTION: The inclusion of simulated patients (SPs) in health professional education is growing internationally. However, there is limited evidence for best practice in SP methodology. This study investigated how experienced SP educators support SPs in providing SP-based education for health professional students. METHODS: Experienced SP educators were identified via relevant professional associations, peer-reviewed publications, and peer referral. Semi-structured individual interviews were conducted via telephone...
August 28, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28794547/evolution-of-ethics-in-clinical-research-and-ethics-committee
#19
Nilay Kanti Das, Amrita Sil
Ethics are the moral values of human behavior and the principles which govern these values. The situation becomes challenging for a doctor when he assumes the role of researcher. The doctor-researcher has to serve both the roles and at times the zeal of an investigator has the potential to cloud the morality of the physician inside. It is very important to realize that exploiting the faith of patients is an offence that tantamount to a crime. Medical science is one discipline where the advancement of knowledge is hugely guided by research and mankind has benefitted from many experiments...
July 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28776177/-rudolf-frey-a-biographical-sketch-on-the-occasion-of-his-100th%C3%A2-birthday
#20
REVIEW
M Goerig, J P A H Jantzen
The life of an outstanding human being, a creative personality, will find the interest of posterity if he is acknowledged not only as a representative of his time but also decades later can be described as a formative character. This applies to Rudolf Frey who, like no other, has deeply influenced the development of German language anesthesiology after the Second World War. In the 1950s and 1960s as a visionary he already portrayed the four pillars of our discipline as the future field of work of anesthetists: anesthesiology, intensive care, emergency medicine and pain therapy...
August 3, 2017: Der Anaesthesist
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