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https://www.readbyqxmd.com/read/28905220/haplotype-study-in-sca10-families-provides-further-evidence-for-a-common-ancestral-origin-of-the-mutation
#1
Giovana B Bampi, Rafael Bisso-Machado, Tábita Hünemeier, Tailise C Gheno, Gabriel V Furtado, Diego Veliz-Otani, Mario Cornejo-Olivas, Pillar Mazzeti, Maria Cátira Bortolini, Laura B Jardim, Maria Luiza Saraiva-Pereira
Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant neurodegenerative disorder characterized by progressive cerebellar ataxia and epilepsy. The disease is caused by a pentanucleotide ATTCT expansion in intron 9 of the ATXN10 gene on chromosome 22q13.3. SCA10 has shown a geographical distribution throughout America with a likely degree of Amerindian ancestry from different countries so far. Currently available data suggest that SCA10 mutation might have spread out early during the peopling of the Americas...
September 13, 2017: Neuromolecular Medicine
https://www.readbyqxmd.com/read/28864723/challenges-and-opportunities-in-adapting-clinical-trial-design-for-immunotherapies
#2
EDITORIAL
Lillian L Siu, S Percy Ivy, Erica L Dixon, Amy E Gravell, Steven A Reeves, Gary L Rosner
Immunotherapy adds an exciting new dimension to the treatment of cancer, joining other approaches as a key pillar in the oncotherapeutics armamentarium. Immuno-oncology agents harbor unique mechanisms of antitumor activity by leveraging the host immune system, which may result in response patterns, resistance kinetics, and toxicity profiles that differ from other systemic therapies. These features have led to many discussions on ways to optimally integrate immunotherapy into cancer clinical trials. This overview provides an introduction to the four CCR Focus articles that ensue, with special thoughts paid to clinical trial endpoints, biomarker development and validation, combination strategies, and limitations that arise with increasing use of these agents...
September 1, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28851383/a-system-approach-to-improving-maternal-and-child-health-care-delivery-in-kenya-innovations-at-the-community-and-primary-care-facilities-a-protocol
#3
Fabian Esamai, Mabel Nangami, John Tabu, Ann Mwangi, David Ayuku, Edwin Were
BACKGROUND: Maternal, fetal and neonatal mortality are higher in low-income compared to high-income countries due to weak health systems including poor access and utilization of health services. Despite enormous recent improvements in maternal, neonatal and under 5 health indicators, more rapid progress is needed to meet the targets including the Development Goal 3(SDG). In Kenya these indicators are still high and comprehensive systems are needed to attain the targets of the SDG 3 by 2030...
August 29, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28845722/the-pillars-of-well-constructed-simulated-patient-programs-a-qualitative-study-with-experienced-educators
#4
Shane A Pritchard, Felicity C Blackstock, Jennifer L Keating, Debra Nestel
INTRODUCTION: The inclusion of simulated patients (SPs) in health professional education is growing internationally. However, there is limited evidence for best practice in SP methodology. This study investigated how experienced SP educators support SPs in providing SP-based education for health professional students. METHODS: Experienced SP educators were identified via relevant professional associations, peer-reviewed publications, and peer referral. Semi-structured individual interviews were conducted via telephone...
August 28, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28794547/evolution-of-ethics-in-clinical-research-and-ethics-committee
#5
Nilay Kanti Das, Amrita Sil
Ethics are the moral values of human behavior and the principles which govern these values. The situation becomes challenging for a doctor when he assumes the role of researcher. The doctor-researcher has to serve both the roles and at times the zeal of an investigator has the potential to cloud the morality of the physician inside. It is very important to realize that exploiting the faith of patients is an offence that tantamount to a crime. Medical science is one discipline where the advancement of knowledge is hugely guided by research and mankind has benefitted from many experiments...
July 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28776177/-rudolf-frey-a-biographical-sketch-on-the-occasion-of-his-100th%C3%A2-birthday
#6
REVIEW
M Goerig, J P A H Jantzen
The life of an outstanding human being, a creative personality, will find the interest of posterity if he is acknowledged not only as a representative of his time but also decades later can be described as a formative character. This applies to Rudolf Frey who, like no other, has deeply influenced the development of German language anesthesiology after the Second World War. In the 1950s and 1960s as a visionary he already portrayed the four pillars of our discipline as the future field of work of anesthetists: anesthesiology, intensive care, emergency medicine and pain therapy...
August 3, 2017: Der Anaesthesist
https://www.readbyqxmd.com/read/28773068/reuse-of-pillaring-agent-in-sequential-bentonite-pillaring-processes
#7
Francine Bertella, Sibele B C Pergher
This work describes the synthesis and characterization of pillared clays using a new pillaring method: the reuse of the pillaring solution. First, an Al pillared clay (PILC) was synthesized, and after filtration, the pillaring agent was stored and reused for an additional three pillaring procedures (P1, P2, and P3). The filtered pillaring solution was stored for one year and then reused for one additional pillaring procedure (P4). The samples were analyzed using XRD, N₂ physisorption measurements and chemical analysis (EDX)...
June 27, 2017: Materials
https://www.readbyqxmd.com/read/28743067/-we-must-cooperate-with-one-another-against-the-enemy-agency-and-activism-in-school-aged-children-as-protective-factors-against-ongoing-war-trauma-and-political-violence-in-the-gaza-strip
#8
Guido Veronese, Alessandro Pepe, Alaa Jaradah, Feda Murannak, Housam Hamdouna
This exploratory qualitative study investigated self-perceived risk and protection factors that may reinforce the ability of children living in refugee camps on the Gaza Strip to adjust to a traumatic and risky life context characterized by loss and dispossession. The sample comprised 200 Palestinian children recruited at primary schools in four refugee camps in the Gaza Strip following the Israeli military operation "Pillar of Defence" in 2012. Thematic content analysis was applied to written materials and narratives produced by the children...
July 22, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28730364/water-resources-vulnerability-assessment-in-the-adriatic-sea-region-the-case-of-corfu-island
#9
Vasilis Kanakoudis, Stavroula Tsitsifli, Anastasia Papadopoulou, Barbara Cencur Curk, Barbara Karleusa
Cross-border water resources management and protection is a complicated task to achieve, lacking a common methodological framework. Especially in the Adriatic region, water used for drinking water supply purposes pass from many different countries, turning its management into a hard task to achieve. During the DRINKADRIA project, a common methodological framework has been developed, for efficient and effective cross-border water supply and resources management, taking into consideration different resources types (surface and groundwater) emphasizing in drinking water supply intake...
July 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28719187/exploring-the-role-of-habitat-on-the-wettability-of-cicada-wings
#10
Junho Oh, Catherine E Dana, Sungmin Hong, Jessica K Román, Kyoo Dong Jo, Je Won Hong, Jonah Nguyen, Donald M Cropek, Marianne Alleyne, Nenad Miljkovic
Evolutionary pressure has pushed many extant species to develop micro/nanostructures that can significantly affect wettability and enable functionalities such as droplet jumping, self-cleaning, antifogging, antimicrobial, and antireflectivity. In particular, significant effort is underway to understand the insect wing surface structure to establish rational design tools for the development of novel engineered materials. Most studies, however, have focused on superhydrophobic wings obtained from a single insect species, in particular, the Psaltoda claripennis cicada...
August 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28713803/the-institute-for-global-orthopedics-and-traumatology-a-model-for-academic-collaboration-in-orthopedic-surgery
#11
Devin James Conway, Richard Coughlin, Amber Caldwell, David Shearer
In 2006, surgeons at the University of California, San Francisco (UCSF) established the Institute for Global Orthopedics and Traumatology (IGOT), an initiative within the department of orthopedic surgery. The principal aim of IGOT is to create long-term, sustainable solutions to the growing burden of musculoskeletal injury in low- and middle-income countries (LMICs) through academic partnership. IGOT currently has relationships with teaching hospitals in Ghana, Malawi, Tanzania, Nicaragua, and Nepal. The organizational structure of IGOT is built on four pillars: Global Surgical Education (GSE), Global Knowledge Exchange (GKE), Global Research Initiative (GRI), and Global Leadership and Advocacy...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28712186/glycaemic-control-of-type-2-diabetic-patients-during-ramazan-fasting
#12
Uzma Malik, Nasir Mahmood, Khurshid Ahmed Khan, Maliha Hameed, Fawad Ahmed Randhawa, Sadia Salman, Amna Riaz, Khadija Waheed, Aqeela Rasheed
BACKGROUND: Among five main pillars of Islam Fasting is one of the key elements, all healthy adult Muslims have to observe fast from dawn till dusk during the holy month of Ramadan. According to a 2009 demographic study, Islam has 1.57 billion believers, making up 23% of the world population of 6.8 billion, and is growing by 3% per year. EPIDIAR (epidemiology of diabetes and Ramadan) study showed that 43% patients with type 1 and 79% patients with type2 diabetes observe fast during the month of Ramadan...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28698774/the-four-pillars-of-alzheimer-s-prevention
#13
Dharma Singh Khalsa, George Perry
Much is yet to be discovered about the precise biological changes that cause Alzheimer's, disease, why it progresses more quickly in some than in others, and how the disease can be prevented, slowed, or stopped. And while researchers continue to search for the magic pill that can prevent or halt the spread of amyloid in the brain, our authors believe that changing or modifying one's lifestyle and attitude can make a difference in both prevention and treatment.
March 2017: Cerebrum: the Dana Forum on Brain Science
https://www.readbyqxmd.com/read/28685037/integrating-palliative-care-into-national-health-systems-in-africa-a-multi-country-intervention-study
#14
Liz Grant, Julia Downing, Emmanuel Luyirika, Mairead Murphy, Liz Namukwaya, Fatia Kiyange, Mackuline Atieno, Emilly Kemigisha-Ssali, Jenny Hunt, Kaly Snell, Scott A Murray, Mhoira Leng
BACKGROUND: The WHO is calling for the integration of palliative care in all health care settings globally. METHODS: A 3.5-year program was implemented in 12 government hospitals, three each in Kenya, Rwanda, Uganda and Zambia. A four-pillared approach of advocacy, staff training, service delivery strengthening and international and regional partnership working was utilized. A baseline assessment was undertaken to ascertain needs, and 27 indicators were agreed to guide and evaluate the intervention...
June 2017: Journal of Global Health
https://www.readbyqxmd.com/read/28626598/design-concerns-of-room-and-pillar-retreat-panels
#15
Ted M Klemetti, Morgan M Sears, Ihsan B Tulu
Why do some room and pillar retreat panels encounter abnormal conditions? What factors deserve the most consideration during the planning and execution phases of mining and what can be done to mitigate those abnormal conditions when they are encountered? To help answer these questions, and to determine some of the relevant factors influencing the conditions of room and pillar (R & P) retreat mining entries, four consecutive R & P retreat panels were evaluated. This evaluation was intended to reinforce the influence of topographic changes, depth of cover, multiple-seam interactions, geological conditions, and mining geometry...
January 2017: International Journal of Mining Science and Technology
https://www.readbyqxmd.com/read/28621374/linker-functionalisation-triggers-an-alternative-3d-topology-for-zn-isophthalate-4-4-bipyridine-frameworks
#16
Andreas Schneemann, Robin Rudolf, Sebastian Henke, Yukiko Takahashi, Hung Banh, Inke Hante, Christian Schneider, Shin-Ichiro Noro, Roland A Fischer
A series of four Zn(2+) metal-organic frameworks containing functionalised isophthalate linkers and 4,4'-bipyridine pillars have been prepared and characterised. Isophthalates which contain -OC3H2n+1 alkoxy side chains (with n = 1, 2 or 3) form frameworks with a 3D pillared-layer topology instead of the typical 2D layer topology of the renowned coordination polymers with an interdigitated structure (CIDs), which is found for shorter -OC2H5 side chains. The gas adsorption properties of the materials were analysed using N2, CO2 and O2 adsorption measurements at low temperatures...
June 27, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28613813/pillared-layer-metal-organic-frameworks-for-improved-lithium-ion-storage-performance
#17
Teng Gong, Xiaobing Lou, En-Qing Gao, Bingwen Hu
Recently, more and more metal-organic frameworks (MOFs) have been directly used as anodic materials in lithium-ion batteries, but judicious design or choice of MOFs is still challenging for lack of structural-property knowledge. In this article we propose a pillared-layer strategy to achieve improved Li-storage performance. Four Mn(II) and Co(II) MOFs with mixed azide and carboxylate ligands were studied to illustrate the strategy. In these 3D MOFs, layers (1, 3, and 4) or chains (2) with short bridges are linked by long organic spacers...
June 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28589444/reflections-on-the-future-of-pharmaceutical-public-private-partnerships-from-input-to-impact
#18
REVIEW
Remco L A de Vrueh, Daan J A Crommelin
Public Private Partnerships (PPPs) are multiple stakeholder partnerships designed to improve research efficacy. We focus on PPPs in the biomedical/pharmaceutical field, which emerged as a logical result of the open innovation model. Originally, a typical PPP was based on an academic and an industrial pillar, with governmental or other third party funding as an incentive. Over time, other players joined in, often health foundations, patient organizations, and regulatory scientists. This review discusses reasons for initiating a PPP, focusing on precompetitive research...
June 6, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28585820/water-vapor-sorption-in-hybrid-pillared-square-grid-materials
#19
Daniel O'Nolan, Amrit Kumar, Michael J Zaworotko
We report water vapor sorption studies on four primitive cubic, pcu, pillared square grid materials: SIFSIX-1-Cu, SIFSIX-2-Cu-i, SIFSIX-3-Ni, and SIFSIX-14-Cu-i. SIFSIX-1-Cu, SIFSIX-3-Ni, and SIFSIX-14-Cu-i were observed to exhibit negative water vapor adsorption at ca. 40-50% relative humidity (RH). The negative adsorption is attributed to a water-induced phase transformation from a porous pcu topology to nonporous sql and sql-c* topologies. Whereas the phase transformation of SIFSIX-1-Cu was found to be irreversible, SIFSIX-3-Ni could be regenerated by heating and can therefore be recycled...
June 19, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28516407/components-of-sustainability-considerations-in-management-of-petrochemical-industries
#20
Amir Aryanasl, Jamal Ghodousi, Reza Arjmandi, Nabiollah Mansouri
Sustainability comprises three pillars of social, environmental, and economic aspects. Petrochemical industry has a great inter-related complex impact on social and economic development of societies and adverse impact on almost all environmental aspects and resource depletion in many countries, which make sustainability a crucial issue for petrochemical industries. This study was conducted to propose components of sustainability considerations in management of petrochemical industries.A combination of exploratory study-to prepare a preliminary list of components of sustainable business in petrochemical industries based on review of literature and Delphi-to obtain experts' view on this preliminary list and provide a detailed list of components and sub-components that should be addressed to bring sustainability to petrochemical industries, were used...
June 2017: Environmental Monitoring and Assessment
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