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Hepatosplenic candidiasis

Domenico Albano, Giovanni Bosio, Mattia Bertoli, Giulia Petrilli, Francesco Bertagna
Hepatosplenic candidiasis is a fungal infection, which mostly affects patients with hematologic malignancies such as leukemia. The pathogenesis of this infection is not clear yet, and the liver is the most commonly affected organ. Diagnosis of hepatosplenic candidiasis can be only established via biopsy, since computed tomography (CT) scan, ultrasonography, and magnetic resonance imaging (MRI) yield non-specific results. The role of fluorine-18 fluorodeoxyglucose positron emission tomography /computed tomography ((18)F-FDG PET/CT) in diagnosis of hepatosplenic candidiasis remains undetermined, considering a few evidences in the literature...
2016: Asia Ocean J Nucl Med Biol
Nataša Čolović, Valentina Arsić Arsenijević, Nada Suvajdžić, Irena Djunić, Dragica Tomin
INTRODUCTION: Acute leukemias treatment requires strong chemotherapy. Patients that develop bone marrow aplasia become immunocompromised, thus becoming liable to bacterial and fungal infections. Fungal infections caused by Candida are frequent. Hepatosplenic candidiasis (HSC) is a frequent consequence of invasive candidiasis which is clinically presented with prolonged febrility unresponsive to antibiotics. CASE OUTLINE: A 53-year-old patient with acute myeloid leukemia was submitted to standard chemotherapy "3+7" regimen (daunoblastine 80 mg i...
May 2015: Srpski Arhiv za Celokupno Lekarstvo
Yuan Wu, Hai-jian Zhou, Jie Che, Wen-ge Li, Fu-ning Bian, Shuan-bao Yu, Li-juan Zhang, Jinxing Lu
BACKGROUND: Candida tropicalis is considered to be the leading pathogen causing nosocomial fungemia and hepatosplenic fungal infections in patients with cancer, particularly those with leukemia. Microsatellite-based typing methods using sets of genetic markers have been developed and reported for population structure analysis of C. albicans, C. glabrata, and C. parapsilosis, but no studies have been published for genetic analysis of C. tropicalis. The objective of this study was to develop new microsatellite loci that have the ability to distinguish among C...
2014: BMC Microbiology
S Jennane, H Eddou, E-M Mahtat, J Konopacki, B Souleau, J-V Malfuson, T de Revel
No abstract text is available yet for this article.
June 2014: Médecine et Maladies Infectieuses
Thomas S Y Chan, Harinder Gill, Yu-Yan Hwang, Joycelyn Sim, Alan C T Tse, Florence Loong, Pek-Lan Khong, Eric Tse, Anskar Y H Leung, Chor-Sang Chim, Albert K W Lie, Yok-Lam Kwong
The frequency of breakthrough invasive fungal diseases (IFDs) during echinocandin therapy is unclear. We retrospectively analyzed 534 hematologic patients treated with echinocandin (caspofungin, N = 55; micafungin, N = 306; anidulafungin, N = 173). Four proven IFDs were found, caused by Candida parapsilosis (N = 2), C. parapsilosis and Candida glabrata (N = 1), and Fusarium species (N = 1). Four cases of possible IFDs were observed, all showing pulmonary infection. One case showed features suggestive of hepatosplenic candidiasis...
March 2014: Annals of Hematology
Cengiz Bayram, Ali Fettah, Nese Yarali, Abdurrahman Kara, Fatih Mehmet Azik, Betul Tavil, Bahattin Tunc
Candida infections are the most frequent infections in neutropenic patients. Hepatosplenic candidiasis (HSC) is a part of disseminated Candida infection that occurs most commonly in patients with hematologic malignancies treated with chemotherapy and requires protracted antifungal therapy. During invasive mycosis with rapid resolution of immunosuppression, immune reconstitution inflammatory syndrome (IRIS) which mimics treatment failure, drug toxicity or breakthrough infections may occur. Manifestation period, histopathologic findings and favorable effect of steroids to its inflammatory symptoms strongly suggest that HSC belongs to the invasive fungal infection induced IRIS...
2012: Mediterranean Journal of Hematology and Infectious Diseases
N De Castro, E Mazoyer, R Porcher, E Raffoux, F Suarez, P Ribaud, O Lortholary, J-M Molina
We report a retrospective study of 24 patients with haematological malignancy and hepatosplenic candidiasis. Clinical and biological features were similar to previous reports. No patient previously received antifungal prophylaxis. Liver or spleen histological examination revealed yeasts in 6/24 patients (25%) on direct examination but all cultures were negative. After a median duration of 7 months, antifungal treatment was discontinued in 58% of the patients with no relapse. Eleven (46%) patients died during follow up...
June 2012: Clinical Microbiology and Infection
B Rammaert, A Desjardins, O Lortholary
Chronic disseminated candidosis, often referred to as hepatosplenic candidosis (HSC), is an infection due to Candida spp. that mainly involves the liver and spleen. HSC occurs mostly in patients after profound and prolonged neutropenia, which is more often seen in patients with acute haematological malignancies. The incidence of HSC ranges from 3% to 29% in patients suffering from Acute Leukaemia. However, it is now seen less frequently with the widespread use of antifungal agents as prophylaxis or as preemptive therapy...
May 2012: Mycoses
O Marchetti, F Lamoth, M Mikulska, C Viscoli, P Verweij, S Bretagne
As culture-based methods for the diagnosis of invasive fungal diseases (IFD) in leukemia and hematopoietic SCT patients have limited performance, non-culture methods are increasingly being used. The third European Conference on Infections in Leukemia (ECIL-3) meeting aimed at establishing evidence-based recommendations for the use of biological tests in adult patients, based on the grading system of the Infectious Diseases Society of America. The following biomarkers were investigated as screening tests: galactomannan (GM) for invasive aspergillosis (IA); β-glucan (BG) for invasive candidiasis (IC) and IA; Cryptococcus Ag for cryptococcosis; mannan (Mn) Ag/anti-mannan (A-Mn) Ab for IC, and PCR for IA...
June 2012: Bone Marrow Transplantation
Michael K W Yang, Y M Lau, F H Lo, Y K Lam, S Y Lin
No abstract text is available yet for this article.
June 2011: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
G Michel
Intensified chemotherapy and hematopoietic stem cell transplantation result in severe and prolonged granulocytopenia with an increased risk of invasive fungal infections. The major fungal species that cause serious infections in cancer patients are Candida species and Aspergillus species. The main features of Candida infection in this context are oropharyngeal candidiasis and Candida esophagitis, chronic disseminated candidiasis, also known as hepatosplenic candidiasis, and candidemia. Aspergillus can cause severe lung infection but also sinusal or CNS infection...
May 2011: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Nobuhiro Watanabe, Kimikazu Matsumoto, Seiji Kojima, Koji Kato
This study aimed to determine the frequency of invasive fungal infection (IFI) in pediatric patients with hematologic malignancy who received amphotericin B oral suspension and early intravenous fluconazole during the neutropenic phase as prophylaxis for IFI. Records of 743 neutropenic episodes induced by cytotoxic chemotherapy between 1997 and 2008 were retrospectively reviewed to determine risk factors for and frequency of IFI. The overall frequency of IFI was 0.8% (n=6) and frequencies of proven, probable, and possible infections were 0...
May 2011: Journal of Pediatric Hematology/oncology
C Hernández Marqués, A Lassaletta-Atienza, M González-Vicent, J Sevilla, B Molina, M Andión, M Cormenzana, A Pérez Martínez, M A Díaz, L Madero
INTRODUCTION: In the last few decades, the survival of children with haematology-oncological malignancies has increased due to more aggressive chemotherapy regimens. This has led to an increase of fungal infections causing significant morbidity and mortality in these patients. Hepatosplenic candidiasis is a disseminated candida infection that affects most commonly the liver and spleen, although other organs may be involved. PATIENTS AND METHODS: We performed a retrospective study of 13 paediatric patients diagnosed with hepatosplenic candidiasis from January 2002 to February 2010 in our paediatric haematology-oncology department following the criteria proposed by the EORTC/MSG (European Organization for Research and Treatment of Cancer and Mycoses study group) updated in 2008...
July 2011: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
Malgorzata Mikulska, Thierry Calandra, Maurizio Sanguinetti, Daniel Poulain, Claudio Viscoli
INTRODUCTION: Timely diagnosis of invasive candidiasis (IC) remains difficult as the clinical presentation is not specific and blood cultures lack sensitivity and need a long incubation time. Thus, non-culture-based methods for diagnosing IC have been developed. Mannan antigen (Mn) and anti-mannan antibodies (A-Mn) are present in patients with IC. On behalf of the Third European Conference on Infections in Leukemia, the performance of these tests was analysed and reviewed. METHODS: The literature was searched for studies using the commercially available sandwich enzyme-linked immunosorbent assays (Platelia™, Bio-Rad Laboratories, Marnes-la-Coquette, France) for detecting Mn and A-Mn in serum...
2010: Critical Care: the Official Journal of the Critical Care Forum
Ozlem Güzel Tunçcan, Zeynep Arzu Yegin, Zübeyde Nur Ozkurt, Gonca Erbaş, Sahika Zeynep Akı, Esin Senol, Münci Yağcı, Gülsan Sucak
OBJECTIVES: Invasive fungal infections (IFI) are a significant cause of morbidity and mortality in hematopoietic stem cell transplant (HSCT) recipients. Hepatosplenic candidiasis (HSC) is defined as a distinct form of invasive candidiasis, with liver, spleen, and kidney involvement, in patients with hematological disorders. METHODS: The charts of 255 patients (male/female 168/87; median age 35 (range 16-71) years) who were evaluated pre-HSCT at the Gazi University Hospital Stem Cell Transplantation Unit between 2003 and 2008, were retrospectively reviewed...
September 2010: International Journal of Infectious Diseases: IJID
Ara Festekjian, Michael Neely
Risk factors for invasive candidiasis in children with candidaemia are poorly defined. We performed a retrospective cohort study of all children with candidaemia at our tertiary children's hospital from 2000 to 2006. Invasive candidiasis was diagnosed by review of the medical record and standardised EORTC/MSG criteria. A variety of risk factors for invasive candidiasis were explored. Of 194 episodes of candidaemia in the microbiology laboratory database, 180 clinical records were available. Evaluation for invasive candidiasis consisted of 174 (97%) echocardiograms, 167 (93%) dilated ophthalmological examinations, 136 (76%) chest CT scans and 108 (60%) abdominal ultrasounds (complete, hepatosplenic or renal)...
March 2011: Mycoses
Marie Saint-Faust, Corinne Boyer, Martine Gari-Toussaint, Anne Deville, Maryline Poiree, Mickael Weintraub, Nicolas Sirvent
First described in HIV-infected patients who recently initiated highly active antiretroviral therapy, the immune reconstitution inflammatory syndrome (IRIS) is best characterized as a collection of inflammatory disorders triggered by rapid resolution of immunosuppression. Treatment of IRIS is a clinical challenge due to the variety of clinical presentations and the presence of multiple pathogens capable of causing the syndrome. Hepatosplenic candidiasis, an uncommon form of invasive Candida species infection, was recently suggested to belong to the spectrum of fungus-related IRIS...
October 2009: Journal of Pediatric Hematology/oncology
Ricardo Rabagliati B, Gino Fuentes L, Ana María Guzmán D, Eric Orellana U, Jorge Oporto C, Igor Aedo C, Marcelo Garrido S, Bruno Nervi N
INTRODUCTION: Invasive fungal disease (IFD) is a severe complication occurring mostly in haematooncological (H-O) patients and hematopoietic stem cell transplant (HSCT) receptors. Our aim was to describe the IFD occurring in our H-O and HSCT patients according to the EORTC/MSG revised criteria. PATIENTS AND METHODS: IFD surveillance was performed in adult patients of the Hospital Clínico Universidad Catolica, Santiago, Chile, from January 2004 to January 2008. RESULTS: A total of 41 IFD episodes were identified in 39 patients; mean age was 46...
June 2009: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
Pierre Teyton, Georges Baillet, Elif Hindié, Jean Emmanuel Filmont, Farid Sarandi, Marie-Elisabeth Toubert, Jean Luc Moretti
No abstract text is available yet for this article.
July 2009: Clinical Nuclear Medicine
Michael Ellis, Basel Al-Ramadi, Roos Bernsen, Jorgen Kristensen, Hussain Alizadeh, Ulla Hedstrom
The diagnostic performance and usefulness of the Platelia antigen and antibody test (Bio-Rad) was investigated in a prospective study of haematological patients at risk for invasive Candida infections. Among 100 patients, 86 were eligible, of whom invasive candidiasis (IC) occurred in 12 (14%), according to the criteria of the European Organization for Research and Treatment of Cancer/Mycoses Study Group. These included candidaemia due to Candida albicans (one patient) or Candida tropicalis (four patients), and hepatosplenic candidiasis (seven patients)...
May 2009: Journal of Medical Microbiology
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