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Central precocious puberty

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https://www.readbyqxmd.com/read/29323691/premature-thelarche
#1
Aditi Khokhar, Angela Mojica
Premature thelarche is a benign condition that affects young girls and may be interpreted as a sign of central precocious puberty (CPP). Parental concern is common when breast development is noted in a young girl. It is important to differentiate premature thelarche from CPP, as the latter is a more serious disorder that may affect final adult height and menarcheal age, and may have psychological implications as well. Distinguishing between the two conditions clinically may help the patients avoid unnecessary testing...
January 1, 2018: Pediatric Annals
https://www.readbyqxmd.com/read/29323690/premature-adrenarche
#2
Laura Novello, Phyllis W Speiser
Adrenarche is when a child's adrenal cortex starts to secrete adrenal androgen precursors. Dehydroepiandrosterone (DHEA) is the most abundant product of the adrenal cortex, and is a weak androgen agonist thought to be responsible for the clinical signs of pubarche by conversion to more potent androgens, testosterone, and dihydrotestosterone. DHEA's extra-adrenal sulfation product, dehydroepiandrosterone sulfate, is a stable marker for adrenal androgenic activity. Pubarche is the physical manifestation of androgenic hormone production, and includes the development of pubic and axillary hair, adult body odor, and acne...
January 1, 2018: Pediatric Annals
https://www.readbyqxmd.com/read/29312590/gnrh-agonist-treatment-for-idiopathic-central-precocious-puberty-can-improve-final-adult-height-in-chinese-girls
#3
Yanqin Ying, Jing Tang, Wei Chen, Zemin Cai, Wan Ting Niu
Object: To study the outcomes of GnRHa on final adult height in Chinese idiopathic central precocious puberty (ICPP) girls and the involved factor(s) that can predict height gain. Methods: We conducted a retrospective analysis on 10 years of data obtained from three clinical hospitals from January 2005 to March 2015, and 101 girls with ICPP, who received GnRHa therapy for more than six months and already reached their adult height were enrolled. Results: Height, bone age, midparent height, HtSDS, sexual development, therapy duration and predicted adult height(PAH)at start and end of GnRHa, and the final adult height(FAH) were recorded and calculated...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29302264/the-influence-of-gonadotropin-releasing-hormone-agonists-on-anthropometric-change-in-girls-with-central-precocious-puberty
#4
Jong Wan Yoon, Hyun A Park, Jieun Lee, Jae Hyun Kim
Purpose: The potential effect of gonadotropin-releasing hormone agonist (GnRHa) treatment on the weight of girls with central precocious puberty (CPP) remains a controversy. We investigated anthropometric changes during and after GnRHa treatment among girls with CPP. Methods: This retrospective study evaluated data from 127 girls with CPP who received GnRHa treatment for ≥2 years. Height, weight, and body mass index (BMI) values were compared at the baseline (visit 1), after 1 year of GnRHa treatment (visit 2), the end of GnRHa treatment (visit 3), and 6-12 months after GnRHa discontinuation (visit 4)...
December 2017: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/29301187/treatment-outcomes-of-gonadotropin-releasing-hormone-agonist-in-obese-girls-with-central-precocious-puberty
#5
Hye Ryun Kim, Hyo-Kyoung Nam, Young-Jun Rhie, Kee-Hyoung Lee
PURPOSE: This study investigated the influence of obesity on the clinical course and effect of gonadotropin-releasing hormone analog (GnRHa) treatment in girls with central precocious puberty (CPP). METHODS: Medical records of 182 girls with CPP treated with GnRHa were reviewed. They were divided into 2 groups: normal weight (n=108) and overweight/obesity (n=74). Chronological age (CA), bone age (BA), difference between BA and CA (BA-CA), standard deviation score (SDS) of height, body mass index (BMI), predicted adult height (PAH), and laboratory findings were compared at baseline, after 1 year, and at the end of GnRHa treatment in both groups...
December 2017: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29280737/a-critical-appraisal-of-the-effect-of-gonadotropin-releasing-hormon-analog-treatment-on-adult-height-of-girls-with-central-precocious-puberty
#6
Abdullah Bereket
Central precocious puberty (CPP) is a diagnosis that pediatric endocrinologists worldwide increasingly make in girls of age 6-8 years and is mostly idiopathic. Part of the reason for increasing referral and diagnosis is the perception among the doctors as well as the patients that treatment of CPP with long-acting gonadotropin-releasing hormon analogues (GnRHa) promote height of the child. Although, the timing and the tempo of puberty does influence statural growth and achieved adult height, the extent of this effect is variable depending on several factors and is modest in most cases...
December 27, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29278519/gnrh-dependent-precocious-puberty-manifested-at-the-age-of-14-months-in-a-girl-with-47-xxx-karyotype
#7
Nicos Skordis, Eleana Ferrari, Aria Antoniadou, Leonidas A Phylactou, Pavlos Fanis, Vassos Neocleous
This case report describes a 47,XXX girl who presented very early, at the age of 14 months, with signs of sexual precocity (breast and pubic hair development, menarche) and was finally diagnosed with GnRH dependent precocious puberty with no evidence of underlying central nervous system pathology. Molecular testing did not identify any genetic defect in any of the genes tested (KISS1, KISS1R, DLK1 and the intronless MKRN3). Though previous studies have shown a link between karyotype 47,XXX and precocious puberty, this is the youngest patient reported so far...
July 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29237522/-an-analysis-of-cardiac-autonomic-nerve-function-in-girls-with-idiopathic-central-precocious-puberty
#8
Lan-Fen Yi, Hong-Xia Wen, Mei Qiu, Xiao-Xiao Cao
OBJECTIVE: To investigate the cardiac autonomic nerve function in girls with idiopathic central precocious puberty (ICPP). METHODS: A total of 66 girls with ICPP were enrolled, among whom 36 were obese and 30 were not obese. A total of 68 age-matched healthy girls (normal controls) and 51 girls with simple obesity were enrolled as controls. All the subjects underwent 24-hour ambulatory electrocardiography, and deceleration capacity of heart rate (DC), acceleration capacity of heart rate (AC), and heart rate variability (HRV), and body mass index (BMI) were compared between groups...
December 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29213166/precocious-puberty-an-experience-from-a-major-teaching-hospital-in-central-saudi-arabia
#9
Huda A Osman, Nasir A M Al-Jurayyan, Amir M I Babiker, Hessah M N Al-Otaibi, Reem D H AlKhalifah, Sharifah D A Al Issa, Sarar Mohamed
Precocious puberty is a developmental process that gives rise to secondary sexual characteristics before the age of 8 years in girls and 9 years in boys. In general, precocious puberty can be classified as central or peripheral. This is a retrospective hospital-based study was conducted at King Khalid University Hospital (KKUH), Riyadh, Saudi Arabia, during the period January 1990 and December 2016. Data were abstracted from the medical records of patients diagnosed with precocious puberty, with special emphasis on age, sex, clinical characteristics, and relevant hormonal assay...
2017: Sudanese Journal of Paediatrics
https://www.readbyqxmd.com/read/29176028/higher-phthalate-concentrations-are-associated-with-precocious-puberty-in-normal-weight-thai-girls
#10
Khomsak Srilanchakon, Thawiphark Thadsri, Chutima Jantarat, Suriyan Thengyai, Wichit Nosoognoen, Vichit Supornsilchai
BACKGROUND: The cause of precocious puberty may be associated with genetics and other conditions such as central nervous system (CNS) insults, or the exposure to endocrine disrupting chemicals (EDCs). Phthalates is known to be one of the EDCs and have estrogenic and antiandrogenic activities, and may be associated with advanced puberty. The objective of the study was to determine the association between urinary phthalate metabolites and advanced puberty. METHODS: A cross-sectional study was conducted in patients with precocious puberty (breast onset <8 years, n=42) and early puberty (breast onset 8-9 years, n=17), compared to age-matched controls (n=77)...
November 25, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29156706/mkrn3-functions-as-a-novel-ubiquitin-e3-ligase-to-inhibit-nptx1-during-puberty-initiation
#11
Huifang Liu, Xiangxin Kong, Fengling Chen
Central precocious puberty (CPP) is attributed to the disorder of some trigger factors those can activate the hypothalamic-pituitary-gonadal axis controlled by GnRH neurons. Many recent studies reveal one of those trigger factors, Makorin ring finger protein 3 (Mkrn3), whose loss-of-function mutations are implicated in CPP. Although Mkrn3 contained zinc Ring finger domain is considered as a putative E3 ubiquitin ligase, its actual function is never reported. Here, our results demonstrated that in mice hypothalamus before and when puberty initiated, Mkrn3 expressed the reversed tendency with Nptx1, which is an important secreted protein for neuron development...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29147481/is-precocious-puberty-linked-to-hypothalamic-expression-of-arginine-phenylalanine-amide-related-peptide
#12
REVIEW
Yuanyuan He, Wen Sun, Jian Yu
The up-regulation and down-regulation of gonadotropin-releasing hormone (GnRH) in central precocious puberty is not yet known. However, recent advances in neuroendocrinology have shown the controlling role of arginine-phenylalanine RF-amide-related peptides (RFRPs) on GnRH secretion in different phenomenon of reproduction such as estrus cycle and pregnancy, but the exact role of RFRPs in puberty and its related pathologic condition, precocious puberty, is not clear yet. This paper hypothesizes that RFRP is a regulatory peptide of puberty and might prevent the precocious puberty...
October 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29145926/corrigendum-to-increased-high-molecular-weight-adiponectin-but-decreased-total-adiponectin-and-kisspeptin-in-central-precocious-puberty-compared-with-aged-matched-prepubertal-girls
#13
Chantacha Sitticharoon, Maynart Sukharomana, Supawadee Likitmaskul, Malika Churintaraphan, Pailin Maikaew
The aim of the present study was to compare serum leptin, kisspeptin, total adiponectin, high molecular weight (HMW) adiponectin and neuropeptide Y (NPY) levels between girls with central precocious puberty (CPP; n=26, 7-9.5 years old) and age-matched controls (n=29) including or excluding obese girls. Leptin and NPY levels were comparable between CPP and control girls. Kisspeptin levels were lower in the CPP than control group, and were positively correlated with oestrogen in the control group and with systolic and diastolic blood pressure in the CPP group...
November 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29131093/metformin-for-rapidly-maturing-girls-with-central-adiposity-less-liver-fat-and-slower-bone-maturation
#14
Francis de Zegher, Cristina García Beltrán, Abel López-Bermejo, Lourdes Ibáñez
BACKGROUND/AIMS: Girls with low-birth weight (LBW) and postnatal weight catch-up tend to develop visceral and hepatic fat excess, which may be accompanied by an upregulated adrenarche with precocious pubarche (PP) and by a rapidly progressive puberty with early menarche and shorter stature. A pilot study suggested that metformin treatment for 4 years reduces central adiposity in LBW-PP girls and normalizes puberty and adult height. In this cohort, we studied the relationship between metformin treatment, bone maturation, and body composition...
November 7, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29114697/effect-of-gonadotropin-releasing-hormone-analogue-on-final-adult-height-among-jordanian-children-with-precocious-puberty
#15
Hala H Swaiss, Nahla M Khawaja, Oraib H Farahid, Anwar M Batieha, Kamel M Ajlouni
To study the effect of gonadotropin-releasing hormone analogue (GnRHa) on final adult height (FAH) among Jordanian children with central precocious puberty (CPP). Methods: It is a retrospective historical cohort study. We assessed the FAH and height gain in 43 children with CPP (39 females and 4 males) who received GnRHa and 13 children with CPP (11 females and 2 males) who did not receive GnRHa and achieved FAH between 2004 and 2014. Final adult height was compared to target height (TH) and mid- parental height (MPH) in both groups...
November 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/29025205/diurnal-variation-of-gonadotropin-levels-in-girls-with-early-stages-of-puberty
#16
Yu Sun Kang, Dong-Yoon Yoo, In Hyuk Chung, Eun-Gyong Yoo
PURPOSE: Pubertal gonadotropin secretion shows circadian pattern and the luteinizing hormone (LH) levels tend to rise in later stages of puberty in girls. We studied the usefulness of basal LH in the evaluation of central precocious puberty with emphasis on the influence of sampling time. METHODS: Medical records of 334 girls that underwent gonadotropin-releasing hormone stimulation test (GnRHST) were reviewed. Auxological and laboratory data were compared between those with early morning (EM, before 10 AM) and late morning/afternoon (LM/A, after 10 AM) basal samples...
September 2017: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29025204/insulin-resistance-and-bone-age-advancement-in-girls-with-central-precocious-puberty
#17
Jin Ho Hur, Sora Park, Mo Kyung Jung, Seok Jin Kang, Ahreum Kwon, Hyun Wook Chae, Ho-Seong Kim, Duk Hee Kim
PURPOSE: Precocious puberty has significantly increased recently. While obesity is associated with puberty timing, the relationship between obesity and central precocious puberty (CPP) remains controversial. The purpose of this study was to determine whether insulin resistance is associated with bone age (BA) advancement in girls with CPP. METHODS: We retrospectively analyzed the records of 804 girls referred for puberty evaluation. Anthropometric measurements, BA, sex hormone, sex hormone binding globulin (SHBG), and insulin levels, lipid profiles, and gonadotropin releasing hormone stimulation tests were assessed...
September 2017: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/28988223/makorin-ring-finger-3-gene-analysis-in-koreans-with-familial-precocious-puberty
#18
Hwal Rim Jeong, Hae Sang Lee, Jin Soon Hwang
BACKGROUND: Precocious puberty is known as an idiopathic, sporadic disease. Recently, specific mutations have been shown to cause familial central precocious puberty (CPP). The makorin ring finger 3 (MKRN3) gene plays a key role in puberty; loss-of-function mutations in the gene trigger familial CPP. To date, most described patients have been Western; few Asians with CPP have been documented. OBJECTIVE: To identify MKRN3 gene mutations or polymorphisms in Korean patients with familial CPP...
October 26, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28975428/a-new-efficient-method-to-monitor-precocious-puberty-nationwide-in-france
#19
Annabel Rigou, Joëlle Le Moal, Juliane Léger, Alain Le Tertre, Jean-Claude Carel
Clinical precocious puberty (PP) is a disease, reputed to be on the increase and suspected to be linked to endocrine disrupting chemicals (EDC) exposure. Population-based epidemiological data are lacking in France and scarce elsewhere. We accessed the feasibility of monitoring PP nationwide in France in this context, using a nationwide existing database, the French National Health Insurance Information System. Here, we present the method we used with a step-by-step approach to build and select the most suitable indicator...
October 3, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28973010/improved-final-predicted-height-with-the-injection-of-leuprolide-in-children-with-earlier-puberty-a-retrospective-cohort-study
#20
Yi-Chun Lin, Chih-Ying Lin, Siew-Yin Chee, Hung-Rong Yen, Fuu-Jen Tsai, Chiu-Ying Chen, Chung-Hsing Wang
The adult height of children with early onset puberty is limited by the premature maturation of hypothalamic-pituitary-gonadal axis. To evaluate the effects of gonadotropin-releasing hormone analog (GnRHa) treatment on the final height (FH) and bone maturation rate (BMR) in girls with early puberty (EP) or idiopathic central precocious puberty (ICPP), we examined data from girls who were diagnosed with EP or ICPP and underwent GnRHa (Leuplin Depot: 3.75 mg/month) at China Medical University Hospital, in Taiwan, between 2006 and 2015...
2017: PloS One
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