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https://www.readbyqxmd.com/read/28341475/genotypic-and-phenotypic-characteristics-of-crb1-associated-retinal-dystrophies-a-long-term-follow-up-study
#1
Mays Talib, Mary J van Schooneveld, Maria M van Genderen, Jan Wijnholds, Ralph J Florijn, Jacoline B Ten Brink, Nicoline E Schalij-Delfos, Gislin Dagnelie, Frans P M Cremers, Ron Wolterbeek, Marta Fiocco, Alberta A Thiadens, Carel B Hoyng, Caroline C Klaver, Arthur A Bergen, Camiel J F Boon
PURPOSE: To describe the phenotype, long-term clinical course, clinical variability, and genotype of patients with CRB1-associated retinal dystrophies. DESIGN: Retrospective cohort study. PARTICIPANTS: Fifty-five patients with CRB1-associated retinal dystrophies from 16 families. METHODS: A medical record review of 55 patients for age at onset, medical history, initial symptoms, best-corrected visual acuity, ophthalmoscopy, fundus photography, full-field electroretinography (ffERG), Goldmann visual fields (VFs), and spectral-domain optical coherence tomography...
March 13, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28325925/the-blood-labyrinthine-barrier-in-the-human-normal-and-meniere-s-disease-macula-utricle
#2
Gail Ishiyama, Ivan A Lopez, Paul Ishiyama, Harry V Vinters, Akira Ishiyama
The ultrastructural organization of the blood labyrinthine barrier (BLB) was investigated in the human vestibular endorgan, the utricular macula, using postmortem specimens from individuals with documented normal auditory and vestibular function and surgical specimens from patients with intractable Meniere's disease. Transmission electron microscopic analysis of capillaries located in the normal human utricular stroma showed vascular endothelial cells with few pinocytotic vesicles, covered by a smooth and uniform basement membrane surrounded by pericyte processes...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28318717/-individualized-management-of-patients-with-exudative-amd-ioi-protocol-injection-observational-individualization
#3
O Semoun, S Y Cohen, M Srour, C Creuzot-Garchet, H Oubraham-Mebroukine, L Kodjikian, F Devin, E H Souied
Wet macular degeneration remains a major cause of visual impairment in people over 55years. Through a group of experts belonging to the Federation France Macula, we review the treatment of wet AMD and provide recommendation with a 3 phases protocol called IOI.
March 16, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28288486/differential-disease-progression-in-atrophic-age-related-macular-degeneration-and-late-onset-stargardt-disease
#4
Moritz Lindner, Stanley Lambertus, Matthias M Mauschitz, Nathalie M Bax, Eveline Kersten, Anna Lüning, Jennifer Nadal, Steffen Schmitz-Valckenberg, Matthias Schmid, Frank G Holz, Carel B Hoyng, Monika Fleckenstein
Purpose: To compare the disease course of retinal pigment epithelium (RPE) atrophy secondary to age-related macula degeneratio (AMD) and late-onset Stargardt disease (STGD1). Methods: Patients were examined longitudinally by fundus autofluorescence, near-infrared reflectance imaging, and best-corrected visual acuity (BCVA). Areas of RPE atrophy were quantified using semi-automated software, and the status of the fovea was evaluated based on autofluorescence and near-infrared reflectance images...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28265823/changes-in-reticular-pseudodrusen-area-in-eyes-that-progressed-from-early-to-late-age-related-macular-degeneration
#5
Patrick A Kaszubski, Tal Ben Ami, Céline Saade, Camellia Nabati, Vivek Kumar, Ana Rita Santos, Rufino Silva, Maria Luz Cachulo, José G Cunha-Vaz, R Theodore Smith
OBJECTIVE: This retrospective cohort study utilized 3 imaging modalities to analyze quantitatively reticular pseudodrusen (RPD) area changes in eyes that progressed from early to late age-related macular degeneration (AMD). METHODS: Subjects with AMD, unilateral choroidal neovascularization (CNV), and early AMD with RPD in the fellow eye (the study eye) were included. The study eyes underwent indocyanine green angiography (ICGA), near-infrared reflectance (NIR-R), and short-wavelength autofluorescence (AF) imaging of the macula at baseline and at follow-up...
March 7, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28259869/one-year-outcomes-of-a-treat-and-extend-regimen-of-aflibercept-for-exudative-age-related-macular-degeneration
#6
Akiko Yamamoto, Annabelle A Okada, Makiko Nakayama, Yumiko Yoshida, Hiroaki Kobayashi
PURPOSE: The aim of this study was to investigate the 1-year outcomes of treat-and-extend aflibercept for exudative age-related macular degeneration (AMD) in Japan. PROCEDURES: Clinical records of 67 patients (67 eyes) were reviewed. Monthly aflibercept was administered until resolution of exudation and maximal reduction of pigment epithelial detachment. Injection intervals were extended by 2-week units up to 12 weeks if no exudation was observed and shortened for recurrence...
March 4, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28228833/disruption-of-the-photoreceptor-inner-segment-outer-segment-junction-in-a-6-year-old-girl-with-joubert-syndrome
#7
Shimpei Baba, Eri Takeshita, Hiroko Yamazaki, Mikako Tarashima, Masayuki Sasaki
Joubert syndrome (JS) is a spectrum of genetic disorders characterised by cerebellar and brainstem malformation called "molar tooth sign", resulting in hypotonia, developmental delay, and intellectual disability. Here we describe a young female JS patient with "salt-and-pepper" fundus and inner segment-outer segment junction (IS/OS line) discontinuity, with a lack of external limiting membrane. Ocular coherence tomography (OCT) detected blurred external retinal layers in the macula centre. Although JS patients often have retinal degeneration with varying severity, few investigators have utilised OCT in their investigations...
February 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/28180131/semiautomated-segmentation-and-analysis-of-retinal-layers-in-three-dimensional-spectral-domain-optical-coherence-tomography-images-of-patients-with-atrophic-age-related-macular-degeneration
#8
Zhihong Hu, Yue Shi, Kiran Nandanan, Srinivas R Sadda
Historically, regular drusen and geographic atrophy (GA) have been recognized as the hallmarks of nonneovascular age-related macular degeneration (AMD). Recent imaging developments have revealed another distinct nonneovascular AMD phenotype, reticular pseudodrusen (RPD). We develop an approach to semiautomatically quantify retinal surfaces associated with various AMD lesions (i.e., regular drusen, RPD, and GA) in spectral domain (SD) optical coherence tomography (OCT) images. More specifically, a graph-based algorithm was used to segment multiple retinal layers in SD-OCT volumes...
January 2017: Neurophotonics
https://www.readbyqxmd.com/read/28178068/features-of-the-macula-and-central-visual-field-and-fixation-pattern-in-patients-with-retinitis-pigmentosa
#9
Isil Sayman Muslubas, Murat Karacorlu, Serra Arf, Mumin Hocaoglu, Mehmet Giray Ersoz
PURPOSE: To evaluate macular features and fixation pattern in patients with retinitis pigmentosa (RP) compared with healthy controls, using spectral-domain optical coherence tomography and MP-1 microperimetry. METHODS: Eighty-one eyes of 81 patients with RP and 90 eyes of 90 healthy subjects were assessed. The central foveal thickness, subfoveal choroidal thickness, ellipsoid zone length, and the mean retinal sensitivities and fixation characteristics were evaluated by spectral-domain optical coherence tomography and MP-1 microperimetry...
February 7, 2017: Retina
https://www.readbyqxmd.com/read/28141749/thickness-of-the-macula-retinal-nerve-fiber-layer-and-ganglion-cell-inner-plexiform-layer-in-the-age-related-macular-degeneration-the-repeatability-study-of-spectral-domain-optical-coherence-tomography
#10
Il-Hwan Shin, Woo-Hyuk Lee, Jong-Joo Lee, Young-Joon Jo, Jung-Yeul Kim
PURPOSE: To determine the repeatability of measuring the thickness of the central macula, retinal nerve fiber layer, and ganglion cell-inner plexiform layer (GC-IPL) using spectral domain optical coherence tomography (Cirrus HD-OCT) in eyes with age-related macular degeneration. METHODS: One hundred and thirty-four eyes were included. The measurement repeatability was assessed by an experienced examiner who performed two consecutive measurements using a 512 × 128 macular cube scan and a 200 × 200 optic disk cube scan...
January 30, 2017: Retina
https://www.readbyqxmd.com/read/28141748/risk-for-low-visual-acuity-after-1-and-2-years-of-treatment-with-ranibizumab-or-bevacizumab-for-patients-with-neovascular-age-related-macular-degeneration
#11
Inger Westborg, Susanne Albrecht, Aldana Rosso
PURPOSE: To investigate how patients with neovascular age-related macular degeneration treated with ranibizumab or bevacizumab respond to treatment in daily clinical practice. METHODS: Data from the Swedish Macula Register on the treatment received by 3,912 patients during 2011 to 2014 is reported. Patients' characteristics at the first visit, visual acuity, number of injections, and reason for terminating the treatment if applicable are discussed. Furthermore, the risk of having poor vision (visual acuity under 60 Early Treatment Diabetes Retinopathy Study letters or approximately 20/60 Snellen) is calculated for the treated eye after 1 year and 2 years...
January 30, 2017: Retina
https://www.readbyqxmd.com/read/28122649/serum-and-macular-response-to-carotenoid-enriched-egg-supplementation-in-human-subjects-the-egg-xanthophyll-intervention-clinical-trial-exit
#12
David Kelly, John M Nolan, Alan N Howard, Jim Stack, Kwadwo O Akuffo, Rachel Moran, David I Thurnham, Jessica Dennison, Katherine A Meagher, Stephen Beatty
The macular carotenoids lutein (L), zeaxanthin (Z) and meso-zeaxanthin (MZ) accumulate at the macula, where they are collectively referred to as macular pigment (MP). Augmentation of this pigment, typically achieved through diet and supplementation, enhances visual function and protects against progression of age-related macular degeneration. However, it is known that eggs are a rich dietary source of L and Z, in a highly bioavailable matrix. In this single-blind placebo-controlled study, L- and MZ-enriched eggs and control non-enriched eggs were fed to human subjects (mean age 41 and 35 years, respectively) over an 8-week period, and outcome measures included MP, visual function and serum concentrations of carotenoids and cholesterol...
January 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28114590/intraocular-vascular-endothelial-growth-factor-levels-in-pachychoroid-neovasculopathy-and-neovascular-age-related-macular-degeneration
#13
Masayuki Hata, Kenji Yamashiro, Sotaro Ooto, Akio Oishi, Hiroshi Tamura, Manabu Miyata, Naoko Ueda-Arakawa, Ayako Takahashi, Akitaka Tsujikawa, Nagahisa Yoshimura
Purpose: To investigate the difference in intraocular vascular endothelial growth factor (VEGF) concentration between pachychoroid neovasculopathy and neovascular age-related macular degeneration (nAMD) and its associations with responses to three monthly anti-VEGF injections as an initial treatment for the two conditions. Methods: This study included nine eyes with treatment-naïve pachychoroid neovasculopathy and 21 eyes with treatment-naïve nAMD. Before the initial intravitreal anti-VEGF injection, aqueous humor samples were collected and the concentration of VEGF was measured using enzyme-linked immunosorbent assay...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28093579/progression-of-transsynaptic-retinal-degeneration-with-spectral-domain-optical-coherence-tomography
#14
Stephen G Schwartz, Armando Monroig, Harry W Flynn
PURPOSE: To illustrate the progression of retrograde transsynaptic retinal degeneration using spectral- domain optical coherence tomography (SD-OCT). OBSERVATIONS: A 60 year-old man with a stroke was followed over a 17-month period using SD-OCT of the macula, ganglion cell layer (GCC), and retinal nerve fiber layer. Transsynaptic retinal degeneration progressed over this time. CONCLUSIONS AND IMPORTANCE: Retrograde transsynaptic retinal degeneration may occur in patients with homonymous visual field loss caused by post-geniculate neurologic disease...
April 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/28091428/refractive-aim-and-visual-outcome-after-phacoemulsification-a-2-year-review-from-a-tertiary-private-eye-hospital-in-sub-saharan-africa
#15
O Oderinlo, A O Hassan, F O Oluyadi, A O Ogunro, O N Okonkwo, M O Ulaikere, O Ashano
AIM: To review the short-term visual outcome of phacoemulsification in adults with uncomplicated cataracts in Eye Foundation Hospital, Lagos, Nigeria. MATERIALS AND METHODS: A retrospective review of records of patients that had phacoemulsification between January 2012 and December 2013 in Eye Foundation Hospital, Lagos, Nigeria, was done. Preoperative visual acuity, refractive aim, intraoperative complications, postoperative unaided, and best-corrected visual acuity at 1 and 3 months were analyzed...
February 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28060400/retinal-detachment-in-a-combined-case-of-stickler-syndrome-and-x-linked-retinoschisis
#16
Neesurg S Mehta, Nicolas A Yannuzzi, Ryan Young, Andrew J McClellan, Sarah P Read, Audina M Berrocal
A 12-year-old boy presented with a total rhegmatogenous retinal detachment and a giant retinal tear in the right eye. Clinical examination, optical coherence tomography, and fundus images showed an optically empty vitreous, lattice degeneration, and retinoschisis of the macula. Genetic testing revealed mutations in the COL2A1 and RS1 genes, confirming a dual diagnosis of Stickler syndrome and X-linked retinoschisis, respectively. This represents the first published account of a patient with both Stickler syndrome and X-linked retinoschisis...
January 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28060148/short-term-safety-of-2-mg-intravitreal-ziv-aflibercept
#17
Jay Chhablani, Chintan Jethalal Dedhia, Hari K Peguda, Michael Stewart
PURPOSE: To evaluate the safety of single intravitreal 2 mg ziv-aflibercept (0.08 mL) injections for the treatment of choroidal neovascular membranes (CNVM). METHODS: Eyes with choroidal neovascular membranes because of several conditions each received single intravitreal injections of 2 mg ziv-aflibercept (0.08 mL). Comprehensive ophthalmic examinations and detailed systemic evaluations were performed at baseline and Days 1, 7, and 30 after injections. Standard electroretinography was performed at baseline and Day 30...
January 2, 2017: Retina
https://www.readbyqxmd.com/read/28058163/clinical-features-and-course-of-patients-with-peripheral-exudative-hemorrhagic-chorioretinopathy
#18
Zafer Cebeci, Yasemin Dere, Şerife Bayraktar, Samuray Tuncer, Nur Kır
OBJECTIVES: To evaluate the clinical characteristics of patients who were followed in our clinic with the diagnosis of peripheral exudative hemorrhagic chorioretinopathy (PEHC). MATERIALS AND METHODS: Medical records of 12 patients who were diagnosed with PEHC in İstanbul University İstanbul Faculty of Medicine, Department of Ophthalmology between July 2006 and June 2014 were reviewed retrospectively. RESULTS: This study included 21 eyes of 12 patients...
October 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28045789/imaging-and-measurement-of-the-preretinal-space-in-vitreomacular-adhesion-and-vitreomacular-traction-by-a-new-spectral-domain-optical-coherence-tomography-analysis
#19
Marcin Stopa, Elżbieta Marciniak, Piotr Rakowicz, Agnieszka Stankiewicz, Tomasz Marciniak, Adam Dąbrowski
PURPOSE: To evaluate a new method for volumetric imaging of the preretinal space (also known as the subhyaloid, subcortical, or retrocortical space) and investigate differences in preretinal space volume in vitreomacular adhesion (VMA) and vitreomacular traction (VMT). METHODS: Nine patients with VMA and 13 with VMT were prospectively evaluated. Automatic inner limiting membrane line segmentation, which exploits graph search theory implementation, and posterior cortical vitreous line segmentation were performed on 141 horizontal spectral domain optical coherence tomography B-scans per patient...
December 30, 2016: Retina
https://www.readbyqxmd.com/read/28018716/machine-learning-based-detection-of-age-related-macular-degeneration-amd-and-diabetic-macular-edema-dme-from-optical-coherence-tomography-oct-images
#20
Yu Wang, Yaonan Zhang, Zhaomin Yao, Ruixue Zhao, Fengfeng Zhou
Non-lethal macular diseases greatly impact patients' life quality, and will cause vision loss at the late stages. Visual inspection of the optical coherence tomography (OCT) images by the experienced clinicians is the main diagnosis technique. We proposed a computer-aided diagnosis (CAD) model to discriminate age-related macular degeneration (AMD), diabetic macular edema (DME) and healthy macula. The linear configuration pattern (LCP) based features of the OCT images were screened by the Correlation-based Feature Subset (CFS) selection algorithm...
December 1, 2016: Biomedical Optics Express
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