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Sodium picosulphate

N Alsalimy, L Madi, A Awaisu
WHAT IS KNOWN AND OBJECTIVE: Constipation is a common disorder among long-term care (LTC) patients due to several factors. However, there are no systematic reviews investigating the use of laxatives for chronic constipation in LTC settings. This study aims to explore the safety and efficacy of laxatives in LTC patients. METHODS: A systematic review of randomized controlled trials (RCTs) describing the efficacy and safety of laxatives for chronic constipation in LTC patients was conducted using the following databases and search engines: MEDLINE, Cochrane Database of Systematic Reviews, ScienceDirect, ProQuest and Google Scholar...
June 9, 2018: Journal of Clinical Pharmacy and Therapeutics
Ilvy van Lieshout, Isabelle D Munsterman, Anne M Eskes, Jolanda M Maaskant, René van der Hulst
Background: An effective and tolerable bowel preparation is important to secure quality of colonoscopies. It remains unclear if sodium picosulphate with magnesium citrate (SPMC), which is considered a tolerable bowel preparation agent, is also an effective alternative for polyethylene glycol (PEG) and sodium phosphate (NaP). Aim: The aim of this article is to compare effectiveness of SPMC to PEG and NaP through assessment of quality of bowel cleansing measured by validated tools...
November 2017: United European Gastroenterology Journal
Vladimir Kojecky, Jan Matous, Radan Keil, Milan Dastych, Zdena Zadorova, Michal Varga, Radek Kroupa, Jiri Dolina, Miroslav Misurec, Ales Hep, Martin Griva
BACKGROUND & AIMS: The optimal duration of bowel preparation has only been assessed for polyethylene glycol (PEG). The aim of the study was to determine the intervals for achieving a satisfactory quality/tolerability of the preparation using PEG/ascorbic acid (PEGA) and sodium picosulphate/magnesium citrate (SPMC), and to compare them with 4L of PEG. METHODS: A randomized, endoscopist-blinded, multicentre study. The 612 outpatients referred to a colonoscopy, were prepared using PEG, SPMC, PEGA...
March 2018: Digestive and Liver Disease
Diogo Turiani de Moura, Hugo Guedes, Verônica Tortoretto, Tayrê Pádua Arataque, Eduardo Guimarães de Moura, Juan Pablo Román, Gustavo Luis Rodela, Everson L Artifon
OBJECTIVES: The purpose of the present study is to compare intestinal preparation with mannitol and sodium picosulphate, assessing patient's acceptance, side effects and cleaning capacity. MATERIAL AND METHODS: This is a prospective, nom randomized, blind study, in which the evaluator had no information about the preparation applied. The sample obtained was divided into two groups according to the bowel preparation applied, with 153 patients prepared with 10% mannitol and 84 patients with sodium picosulfate...
October 2016: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
V G M Prasad, Philip Abraham
AIM: The aim of this review is to provide an overview of the clinical assessment and evidence-based treatment options for managing diabetes-associated chronic constipation. METHODS: A literature search of published medical reports in English language was performed using the OVID Portal, from PUBMED and the Cochrane Database of Systematic Reviews, from inception to October 2015. A total of 145 abstracts were identified; duplicate publications were removed and 95 relevant full-text articles were retrieved for potential inclusion...
January 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
Davide Romani, Isabel Salas Tonello, Silvia Antonia Brandán
In this work, the influence of the different S═O, S-O, N⋯H, O⋯H, Na⋯O bonds present in the structures of the powerful laxative drug, sodium picosulphate in gas and aqueous solution phases were studied combining the density functional theory (DFT) calculations with the experimental available infrared, (1)H NMR and UV-visible spectra. The structural, topological, electronic and vibrational properties were investigated in both media by using the hybrid B3LYP/6-31G* method and the integral equation formalism variant polarised continuum model (IEFPCM)...
November 2016: Heliyon
T Voiosu, Alina Tanţău, A Voiosu, Andreea Benguş, Cristina Mocanu, Bianca Smarandache, C Baicuş, Ioana Vişovan, B Mateescu
BACKGROUND: Optimal bowel preparation is one of the most important factors affecting the quality of colonoscopy. Several patient-related factors are known to influence the quality of bowel cleansing but randomized trials in this area are lacking. We aimed to compare an individualized bowel prep strategy based on patient characteristics to a standard preparation regimen. MATERIAL AND METHODS: We conducted an endoscopist-blinded multicenter randomized control-trial...
March 1, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
Thomas Berger, Martin Classen, Harald Engelhardt, Klaus-Michael Keller, Martin W Laass, Ralph Melchior, Carsten Posovszky, Burkhard Rodeck, Katharina Schaper, Rolf Behrens
BACKGROUND AND STUDY AIMS: The goal of this study was to analyze the bowel cleansing methods currently used for pediatric colonoscopy in terms of effectiveness, tolerance and safety. PATIENTS AND METHODS: Data from 768 colonoscopies reported by 28 centers were registered in an online database for further analysis. Binary logistic regression was used to determine how preparation methods affected the cleaning effect (Aronchick score) and the rate of adverse events (Aes) and complications...
July 2016: Endoscopy International Open
Lene Jarlbæk, Berit Johnsen, Ole Bo Hansen, Birte Hedal
The evidence for treatment of constipation in palliative care patients is poor. The condition of these patients is often complex, and results from studies performed in other patient groups cannot be extrapolated unconditionally. However, macrogol (polyethylene glycol), lactulose and sodium picosulphate seem to be well tolerated, and methylnaltrexone could be used in opioid-induced constipation, if the patients are not at risk from gastrointestinal perforation. The patients should be offered quiet and private surroundings, and attention should be payed to securing an optimal body position for defecation...
August 15, 2016: Ugeskrift for Laeger
Hyun Joo Song, Jeong Seop Moon, Ki-Nam Shim
During video capsule endoscopy (VCE), several factors, such as air bubbles, food material in the small bowel, and delayed gastric and small bowel transit time, influence diagnostic yield, small bowel visualization quality, and cecal completion rate. Therefore, bowel preparation before VCE is as essential as bowel preparation before colonoscopy. To date, there have been many comparative studies, consensus, and guidelines regarding different kinds of bowel cleansing agents in bowel preparation for small bowel VCE...
2016: Gastroenterology Research and Practice
Muhammad Saqlain Tahir, Rizwan Mahmood, Waseemur Rahman Shamsi
A simple, fast, precise, economic, selective and accurate HPLC method for simultaneous estimation of sorbicacid, sodium picosulphate and methyl parabensodium in laxative drops has been developed and subsequently validated. Chromatographic separation was achieved using gradient elution with mix phosphate buffer pH 7.0 and acetonitrile. The column used was purospherstar C18, 5 μm, 25 cm × 4.6mm kept at 25°C with 1 ml/min flow rate using detection (PDA) at 263 nm. The retention times of sorbicacid, sodium picosulphate and methyl paraben sodium were found to be 4...
November 2015: Pakistan Journal of Pharmaceutical Sciences
T Matsumura, M Arai, H Ishigami, K Okimoto, K Saito, S Minemura, D Maruoka, T Nakagawa, T Katsuno, O Yokosuka
AIM: This study aimed to investigate the clinical utility of a prepackaged low-residue diet (PLD) compared with a restricted diet (RD) for colonoscopic bowel preparation. METHOD: A prospective randomized controlled trial was carried out with patients undergoing colonoscopy. One hundred patients were randomly assigned to PLD and RD groups. In the RD group, the patients received an information sheet containing acceptable low-residue options and instructions from the medical staff...
January 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Vedrana Vejzovic, Anne Wennick, Ewa Idvall, Daniel Agardh, Ann-Cathrine Bramhagen
OBJECTIVES: The purpose of this randomised study was to compare the quality of bowel cleansing using either polyethylene glycol (PEG) or sodium picosulphate (NaPico) (primary outcome) in relation to the tolerability and acceptance of these laxatives among children and their caregivers (secondary outcome). METHODS: The study was a randomised controlled trial that was conducted as an investigator-blinded study within the Department of Paediatrics of Skåne University Hospital in Malmö, Sweden...
March 2016: Journal of Pediatric Gastroenterology and Nutrition
Julie Jordan-Ely, John M Hutson, Bridget R Southwell
AIM: Constipation is a common cause of admission to hospital for disimpaction, as oral laxatives are often inadequate. High-dose oral laxative protocols are used for complete bowel clearance prior to colonoscopy, but have not been reported for treating faecal impaction. The aim of this study was to assess the effectiveness of a high-dose oral protocol using polyethylene glycol with electrolytes (PEG + E) (Movicol Rx) combined with sodium picosulphate (SP) (Dulcolax SP Rx) in faecal impaction in children presenting to a suburban clinic...
December 2015: Journal of Paediatrics and Child Health
Z Heetun, R Crowley, F Zeb, D Kearns, M H Brennan, C O'Connor, G Courtney, A R Aftab
INTRODUCTION: Adequate bowel preparation is necessary for a complete colonoscopy. Polyethylene glycol-electrolyte oral solution (PEG-EOS), sodium picosulphate (SS) and sodium biphosphonate (SP) are the three most commonly used purgative agents. We aimed to determine their efficacy and tolerability compared to each other in a randomised study. METHODS: 313 patients were randomly assigned to receive either PEG-EOS, SS or SP. Patients completed a tolerability score pre-colonoscopy...
August 2016: Irish Journal of Medical Science
Isabelle D Munsterman, Eva Cleeren, Tjeerd van der Ploeg, Richard Brohet, René van der Hulst
OBJECTIVES: Adequate bowel preparation is an important step for an effective colonoscopy. Polyethylene glycol solution (Kleanprep) and sodium picosulphate with a magnesium citrate solution (Picoprep) are bowel cleansing agents registered and available for this purpose. So far, the results of studies comparing the effectiveness of bowel cleansing between the two agents are inconclusive. This may be because of differences in administration regimes and subjective measurement of bowel cleansing...
January 2015: European Journal of Gastroenterology & Hepatology
S M Sahebally, J P Burke, S Chu, O Mabadeje, J Geoghegan
INTRODUCTION: Adequate bowel cleansing which is acceptable to the patient is a prerequisite for safe and effective colonoscopy. A 2-L polyethylene glycol solution containing ascorbic acid and electrolytes (PEG-Asc) is an alternative to sodium picosulphate + magnesium citrate (SPS-Mg) for bowel preparation. The aim of the current study is to compare PEG-Asc to SPS-Mg in terms of tolerability and efficacy. METHODS: This was a single blind, randomized controlled trial...
December 2015: Irish Journal of Medical Science
Vladimir Kojecky, Jiri Dolina, Bohuslav Kianicka, Miroslav Misurec, Michal Varga, Jiri Latta, Vladimir Vaculin
BACKGROUND & AIMS: To compare the efficacy and tolerance of sodium picosulphate/magnesium citrate (PMC) and polyethylene glycol (PEG) in a single or split dose regimen for colonoscopy bowel preparation. METHODS: A prospective, randomized, endoscopist-blinded, multicenter study. The patients were randomly assigned to receive PMC (PMC4/0) or PEG (PEG4/0) in a single dose 4L day before colonoscopy or a split dose 2+2L PMC (PMC2/2) or 3+1L PEG (PEG3/1) one day before and in the morning before the colonoscopy...
June 2014: Journal of Gastrointestinal and Liver Diseases: JGLD
Theodor Voiosu, Iulia Ratiu, Andrei Voiosu, Tiberiu Iordache, Adrian Schipor, Cristian Baicus, Ioan Sporea, Radu Voiosu
BACKGROUND & AIMS: Good bowel cleansing is essential to achieving optimal endoscopic evaluation of the colon. There are many different regimens available, but none have shown consistently superior results in achieving a clean colon. We compared the efficiency of two regimens with regard to bowel cleansing and patient satisfaction. The study also aimed to identify patient-related factors that influenced the quality of the bowel cleansing. METHODS: We conducted a single-blind, multicenter, randomized controlled trial comparing sodium picosulphate and magnesium citrate versus 4-liter split-dose polyethylene glycol (PEG)...
June 2013: Journal of Gastrointestinal and Liver Diseases: JGLD
Won Moon
Effective colonoscopy requires an adequate level of cleansing as a basic component. This review will describe a compact review about general considerations in bowel preparation for colonoscopy and specific considerations for various patients. A low-fiber diet instead of a regular diet on the day before colonoscopy is an independent predictor of adequate bowel preparation. Improved bowel cleansing does not result from the routine use of enemas or prokinetics in addition to oral bowel preparation. For morning colonoscopy, a split method of 4 L polyethylene glycol on the day before and the day of colonoscopy is recommended, while patients scheduled for afternoon colonoscopy typically receive a full method of 4 L polyethylene glycol on the day of the procedure...
May 2013: Clinical Endoscopy
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