Karline da Costa Rodrigues, Manoel Rodrigues da Silva Neto, Victor Dos Santos Barboza, Sandra Elisa Hass, Rodrigo de Almeida Vaucher, Janice Luehring Giongo, Ricardo Frederico Schumacher, Ethel Antunes Wilhelm, Cristiane Luchese
This study aimed to investigate the action of two different formulations of curcumin (Cur)-loaded nanocapsules (Nc) (Eudragit [EUD] and poly (ɛ-caprolactone) [PCL]) in an amnesia mice model. We also investigated the formulations' effects on scopolamine-induced (SCO) depressive- and anxiety-like comorbidities, the cholinergic system, oxidative parameters, and inflammatory markers. Male Swiss mice were randomly divided into five groups (n = 8): group I (control), group II (Cur PCL Nc 10 mg/kg), group III (Cur EUD Nc 10 mg/kg), group IV (free Cur 10 mg/kg), and group V (SCO)...
February 14, 2024: Metabolic Brain Disease