Yurie Futoh, Hideyo Miyato, Hironori Yamaguchi, Misaki Matsumiya, Rei Takahashi, Yuki Kaneko, Yuki Kimura, Hideyuki Ohzawa, Naohiro Sata, Joji Kitayama, Yoshinori Hosoya
The vagus nerve is the only pathway for transmitting parasympathetic signals between the brain and thoracoabdominal organs, thereby exhibiting anti-inflammatory functions through the cholinergic anti-inflammatory pathway. Despite often being resected during lymph node dissection in upper gastrointestinal cancer surgery, the impact of vagotomy on postoperative outcomes in gastric cancer patients remains unclear. Sub-diaphragmatic vagotomy was performed on C57BL/6 mice. Three weeks later, syngeneic murine gastric cancer cell line YTN16P was injected into the peritoneal cavity, and the number of peritoneal metastases (PM) on the mesentery and omentum compared with control mice...
April 3, 2024: Scientific Reports