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Lisa C Martial, Ruud H J Verstegen, Elisabeth A M Cornelissen, Rob E Aarnoutse, Michiel F Schreuder, Roger J M Brüggemann
OBJECTIVES: The Radboudumc Amalia Children's hospital in the Netherlands has a programme for renal transplantation in children aged ≤4 years. Children receive chronic corticosteroid sparing immunosuppressive therapy that consists of tacrolimus and mycophenolate mofetil. This work aimed to describe the PK of tacrolimus in children ≤4 years with renal transplants. METHODS: Paediatric renal transplant patients aged ≤4 years were included in this analysis. A PK curve of tacrolimus recorded ≤3 weeks after transplantation has been standard of care in our institution and aided in adjusting the dose in each patient to attain a target AUC0-12h of 210 μg h/l early after transplantation...
September 27, 2016: Journal of Pharmacy and Pharmacology
Catelijne H Coppens, Lenie van den Engel-Hoek, Horst Scharbatke, Sandra A F de Groot, Jos M T Draaisma
UNLABELLED: Dysphagia is a common problem in children with repaired oesophageal atresia (OA). Abnormalities in the oropharyngeal and oesophageal phase have hardly been studied. The aims of this study were to assess the prevalence of dysphagia in children with repaired OA and to identify and differentiate oral and pharyngeal dysphagia based on videofluoroscopic swallow study (VFSS) findings in a limited number of children in this cohort. Medical records of 111 patients, born between January 1996 and July 2013 and treated at the Radboudumc Amalia Children's Hospital, were retrospectively reviewed...
September 2016: European Journal of Pediatrics
Sytske Jansen, Olga Meulenbroek, Marcel G M Olde Rikkert
INTRODUCTION: The National Research Agenda (NWA) assembles topics on which scientist can focus in the coming years. A study carried out by de Radboudumc in Nijmegen examined how many questions are put to the NWA on dementia and ageing. What priority does society give to this research field and who ask questions about this? With the method of the NWA as reference frame a supplementary route on dementia/ageing was proposed. RESULTS: Of the 11.700 questions submitted to the NWA almost 2...
September 2016: Tijdschrift Voor Gerontologie en Geriatrie
Rebecca M Koch, Matthijs Kox, Peter Pickkers, Marien I de Jonge
The "experimental cold model" is widely used to investigate effects of HRV infection. However, effects of serostatus and gender on the HRV-induced immune response have not been clarified. 40 healthy seropositive and seronegative (1:1) male and female (1:1) subjects were inoculated with HRV-16. HRV infection increased viral load in nasal wash, which tended to be more pronounced in seronegative subjects. Furthermore, HRV infection increased levels of IP-10, IL-6, and IL-10 and leukocyte numbers in nasal wash of seronegative, but not of seropositive subjects...
July 29, 2016: Vaccine
Jos Hendrikx, Wietske Kievit, Jaap Fransen, Piet L C M van Riel
OBJECTIVE: The objectives of this study were twofold: to assess if there are independent effects of variables representing patients' perceptions of disease on intensification of drug therapy in patients with RA seen in daily practice; and to test the hypothesis that effects of patients' perceptions of disease are mediated through patient self-reported willingness to alter therapy. METHODS: Before being seen by a physician, consecutive patients with RA, attending the Radboudumc outpatient rheumatology clinic, were asked to fill out a short questionnaire regarding the following four items: perceived health change, satisfaction with current health, willingness to change therapy and expected health change until the next visit...
March 23, 2016: Rheumatology
Judith L Bonnes, Sjoerd W Westra, Leon H R Bouwels, Menko Jan DE Boer, Marc A Brouwer, Joep L R M Smeets
INTRODUCTION: In view of the shift from routine toward no or selective defibrillation testing, optimization of the current risk stratification for inadequate defibrillation safety margins (DSMs) could improve individualized testing decisions. Given the pathophysiological differences in myocardial substrate between ischemic and nonischemic heart disease (IHD/non-IHD) and the accompanying differences in clinical characteristics, we studied inadequate DSMs and their predictors in relation to the underlying etiology...
May 2016: Journal of Cardiovascular Electrophysiology
Joanna Lange, Lucjan S Wyrwicz, Gert Vriend
UNLABELLED: Intrinsically disordered proteins (IDPs) lack tertiary structure and thus differ from globular proteins in terms of their sequence-structure-function relations. IDPs have lower sequence conservation, different types of active sites and a different distribution of functionally important regions, which altogether make their multiple sequence alignment (MSA) difficult. The KMAD MSA software has been written specifically for the alignment and annotation of IDPs. It augments the substitution matrix with knowledge about post-translational modifications, functional domains and short linear motifs...
March 15, 2016: Bioinformatics
Judith L Bonnes, Jos Thannhauser, Mathilde C Hermans, Sjoerd W Westra, Thom F Oostendorp, Gjerrit Meinsma, Menko Jan de Boer, Marc A Brouwer, Joep L R M Smeets
BACKGROUND: Characteristics of the ventricular fibrillation (VF) waveform reflect arrest duration and have been incorporated in studies on algorithms to guide resuscitative interventions. Findings in animals indicate that VF characteristics are also affected by the presence of a previous myocardial infarction (MI). As studies in humans are scarce, we assessed the impact of a previous MI on VF characteristics in ICD-patients. METHODS: Prospective cohort of ICD-patients (n=190) with defibrillation testing at the Radboudumc (2010-2013)...
November 2015: Resuscitation
Bram Tilburgs, Marjan D Nijkamp, Esther C Bakker, Hans van der Hoeven
OBJECTIVES: To determine the influence of instrumental, emotional and informative support on the quality of life of former intensive care unit (ICU) patients and to establish their preferred sources of social support. RESEARCH METHODOLOGY: In a cross-sectional survey, former intensive care patients (n=88) completed the "social support interactions/discrepancies list", the "RAND-36 Health Survey" and reported their preferred sources of the different types of social support...
December 2015: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
Nina Ooms, Lucas E M Matthyssens, Jos MTh Draaisma, Ivo de Blaauw, Marc H W A Wijnen
Purpose Intestinal malrotation is a congenital intestinal rotation anomaly, which can be treated by either laparotomy or laparoscopy. Our hypothesis is that laparoscopic treatment leads to less small bowel obstruction because of the fewer adhesions in comparison to laparotomy, without increasing the risk of recurrent volvulus. We analyzed the outcome of patients who had a correction for intestinal malrotation after the introduction of laparoscopy. Methods All patients between 0 and 18 years who underwent a surgical procedure for malrotation in the Radboudumc Amalia Children's Hospital, Nijmegen, the Netherlands, between January 2004 and December 2011 were retrospectively reviewed for duration of operation, perioperative complications, length of hospital stay, and rate of redo surgery for intestinal volvulus or obstruction...
August 2016: European Journal of Pediatric Surgery
F Hinten, L C G van den Einden, M Cissen, J IntHout, L F A G Massuger, J A de Hullu
OBJECTIVE: The overall 5-year survival of patients with vulvar squamous cell carcinoma (SCC) is 70%. The clinical impression is that localization of SCC on the clitoris may lead to worse prognosis. The aim of this study is to assess the disease specific survival (DSS) in patients with clitoral SCC compared to patients with SCC without clitoral involvement. METHODS: All consecutive patients with primary vulvar SCC treated with surgery at the Department of Gynaecologic Oncology at the Radboud university medical centre (Radboudumc) between March 1988 and January 2012, were analysed...
April 2015: European Journal of Surgical Oncology
Hieronymus D Boogaarts, Mariana P Duarte Conde, Edith Janssen, Willemijn F M van Nuenen, Joost de Vries, Rogier Donders, Gert P Westert, J André Grotenhuis, Ronald H M A Bartels
BACKGROUND: Several studies have included different co-morbid conditions in prediction models for stroke patients. For subarachnoid haemorrhage (SAH), it is not known whether the Charlson Co-morbidity Index (CCI) is associated with outcome. We evaluated if this index was associated with outcome in patients with ruptured intracerebral aneurysms. METHODS: The data of all consecutive aneurysmal SAH (aSAH) patients treated at the Radboudumc, Nijmegen, The Netherlands and entered in the database were retrospectively analysed...
September 2014: Acta Neurochirurgica
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