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Azithromycin asthma

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https://www.readbyqxmd.com/read/29755754/-chlamydia-pneumoniae-induced-tumour-necrosis-factor-alpha-responses-are-lower-in-children-with-asthma-compared-with-non-asthma
#1
Tamar Anne Smith-Norowitz, Kobkul Chotikanatis, Diana Weaver, Jared Ditkowsky, Yitzchok Meir Norowitz, Margaret R Hammerschlag, Rauno Joks, Stephan Kohlhoff
Introduction: Chlamydia pneumoniae respiratory tract infection has been implicated in the pathogenesis of reactive airway disease and asthma. Innate cytokine responses that are protective of infection with intracellular pathogens may be impaired in patients with asthma. Tumour necrosis factor alpha (TNF-α) is a cytokine related to functions of monocytes and may inhibit C. pneumoniae infection. We investigated TNF-α responses in C. pneumoniae -infected peripheral blood mononuclear cells (PBMCs) in patients with asthma and non-asthma, and whether ciprofloxacin, azithromycin or doxycycline affects TNF-α responses...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29733738/case-study-a-combination-of-mepolizumab-and-omaluzimab-injections-for-severe-asthma
#2
Rejmon Dedaj, Lindie Unsel
A Combination of Mepolizumab and Omaluzimab injections for severe asthma. INTRODUCTION: Patients with severe persistent asthma account for a large proportion of asthma morbidity and health care expenditures. In this case report we describe the use of a combination of omalizumab and mepolizumab in severe asthma with elevated IgE levels and eosinophilic phenotype. CASE STUDY: We are treating a 55 year old woman with severe persistent eosinophilic asthma and elevated IgE levels...
May 7, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29720921/disulfiram-like-reaction-involving-ceftriaxone-in-a-pediatric-patient
#3
Stephen M Small, Rachel S Bacher, Sheridan A Jost
Several medications have been shown to cause disulfiram-like reactions in patients concomitantly exposed to ethanol, including specific cephalosporin antibiotics that possess a methylthiotetrazole substituent. Within the cephalosporin class, there are few reports of disulfiram-like reactions with ceftriaxone. This case report is the first to involve a pediatric patient, and it describes a mild but likely disulfiram-like reaction manifesting as facial flushing in an 8-year-old male upon receiving a ceftriaxone infusion preceded by a dose of prednisolone elixir (5% ethanol by volume) for presumed community-acquired pneumonia thought to be complicated by an asthma exacerbation...
March 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/29666383/effect-of-antibiotic-use-for-acute-bronchiolitis-on-new-onset-asthma-in-children
#4
I-Lun Chen, Hsin-Chun Huang, Yu-Han Chang, Hsin-Yi Huang, Wei-Ju Yeh, Ting-Yi Wu, Jau-Ling Suen, San-Nan Yang, Chih-Hsing Hung
Early-life use of antibiotics is associated with asthma. We examined the effect of antibiotic use for early-life bronchiolitis on the development of new-onset asthma in children from Taiwan between 2005 and 2010. Data were from the National Health Insurance Research Database 2010, and diseases were coded using the International Classification of Disease (ICD). We classified the patients, all of whom had bronchiolitis, as having asthma or not having asthma. Asthma was diagnosed using ICD criteria and by use of an inhaled bronchodilator and/or corticosteroid twice in one year...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29615379/doxycycline-suppresses-chlamydia-pneumoniae-induced-interferon-gamma-responses-in-peripheral-blood-mononuclear-cells-in-children-with-allergic-asthma
#5
Tamar A Smith-Norowitz, Diana Weaver, Yitzchok M Norowitz, Margaret R Hammerschlag, Rauno Joks, Helen G Durkin, Stephan Kohlhoff
Persistent respiratory infections caused by Chlamydia pneumoniae have been implicated in the pathogenesis of chronic diseases (e.g. asthma). Antibiotics are used to treat C. pneumoniae respiratory infections; however, the use of antibiotics as anti-inflammatory agents in treatment of asthma remains controversial. The current study investigated whether ciprofloxacin, azithromycin, or doxycycline can suppress C. pneumoniae-induced production of immunoglobulin (Ig) E or cytokines in peripheral blood mononuclear cells (PBMC) obtained from asthmatic children...
June 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29337458/-pulmonary-diseases-asthma-copd-and-sleep-apnea-syndrome
#6
Béatrice Duxbury, Émilie Chappuis-Gisin, Salim Chucri, Jean-Paul Janssens
Among the novelties described in the management of pulmonary disorders during the year 2017, we chose to describe three. First, the indication for inhaled glucocorticosteroids (ICS) in COPD has been revisited, because of their relationship with an increased occurence of pneumonia : ICS are now recommended only in severe COPD (GOLD D) with frequent exacerbations as second line treatment. Secondly, azithromycine has shown very promising results in poorly controlled severe asthma, with a significant impact on symptoms and exacerbations...
January 10, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29290744/antimicrobial-stewardship-program-using-plan-do-study-act-cycles-to-reduce-unjustified-antibiotic-prescribing-in-children-admitted-with-an-asthma-exacerbation
#7
Sasha E Dorzin, Claudia Halaby, Maria Lyn Quintos, Asif Noor, Gladys El-Chaar
OBJECTIVE: Antimicrobial stewardship programs (ASPs) ensure appropriate antibiotic use, reduce health care costs, and minimize antibiotic resistance. National asthma guidelines do not recommend antibiotics during an exacerbation unless the child has an infection or comorbidities. The American Academy of Pediatrics (AAP) established a benchmark for unjustified antibiotic use at 6.6%.9 A retrospective study at our institution showed that 7.8% of antibiotics were prescribed without justification in children admitted for asthma...
November 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/29127369/suppression-of-th17-polarized-airway-inflammation-by-rapamycin
#8
Oana Joean, Anja Hueber, Felix Feller, Adan Chari Jirmo, Matthias Lochner, Anna-Maria Dittrich, Melanie Albrecht
Because Th17-polarized airway inflammation correlates with poor control in bronchial asthma and is a feature of numerous other difficult-to-treat inflammatory lung diseases, new therapeutic approaches for this type of airway inflammation are necessary. We assessed different licensed anti-inflammatory agents with known or expected efficacy against Th17-polarization in mouse models of Th17-dependent airway inflammation. Upon intravenous transfer of in vitro derived Th17 cells and intranasal challenge with the corresponding antigen, we established acute and chronic murine models of Th17-polarised airway inflammation...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29049761/azithromycin-reduced-exacerbations-and-improved-qol-in-symptomatic-asthma-despite-inhaled-maintenance-therapy
#9
COMMENT
Matthew B Stanbrook
No abstract text is available yet for this article.
October 17, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28771627/treatment-of-preschool-children-presenting-to-the-emergency-department-with-wheeze-with-azithromycin-a-placebo-controlled-randomized-trial
#10
RANDOMIZED CONTROLLED TRIAL
Piush J Mandhane, Patricia Paredes Zambrano de Silbernagel, Yin Nwe Aung, Janie Williamson, Bonita E Lee, Sheldon Spier, Mary Noseworthy, William R Craig, David W Johnson
BACKGROUND: Antibiotics are frequently used to treat wheezing children. Macrolides may be effective in treating bronchiolitis and asthma. METHOD: We completed a prospective, double-blinded, randomized placebo-control trial of azithromycin among pre-school children (12 to 60 months of age) presenting to the emergency department with wheeze. Patients were randomized to receive either five days of azithromycin or placebo. Primary outcome was time to resolution of respiratory symptoms after treatment initiation...
2017: PloS One
https://www.readbyqxmd.com/read/28735295/azithromycin-for-episodes-with-asthma-like-symptoms-in-young-children-aged-1-3-years
#11
Katy McConnell, Michael Shields
No abstract text is available yet for this article.
December 2017: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/28687413/effect-of-azithromycin-on-asthma-exacerbations-and-quality-of-life-in-adults-with-persistent-uncontrolled-asthma-amazes-a-randomised-double-blind-placebo-controlled-trial
#12
Peter G Gibson, Ian A Yang, John W Upham, Paul N Reynolds, Sandra Hodge, Alan L James, Christine Jenkins, Matthew J Peters, Guy B Marks, Melissa Baraket, Heather Powell, Steven L Taylor, Lex E X Leong, Geraint B Rogers, Jodie L Simpson
BACKGROUND: Exacerbations of asthma cause a substantial global illness burden. Adults with uncontrolled persistent asthma despite maintenance treatment require additional therapy. Since macrolide antibiotics can be used to treat persistent asthma, we aimed to assess the efficacy and safety of oral azithromycin as add-on therapy in patients with uncontrolled persistent asthma on medium-to-high dose inhaled corticosteroids plus a long-acting bronchodilator. METHODS: We did a randomised, double-blind, placebo controlled parallel group trial to determine whether oral azithromycin decreases the frequency of asthma exacerbations in adults (≥18 years) with symptomatic asthma despite current use of inhaled corticosteroid and long-acting bronchodilator, and who had no hearing impairment or abnormal prolongation of the corrected QT interval...
August 12, 2017: Lancet
https://www.readbyqxmd.com/read/28687412/azithromycin-in-uncontrolled-asthma
#13
COMMENT
Guy Brusselle, Ian Pavord
No abstract text is available yet for this article.
August 12, 2017: Lancet
https://www.readbyqxmd.com/read/28671393/top-20-research-studies-of-2016-for-primary-care-physicians
#14
REVIEW
Mark H Ebell, Roland Grad
This article summarizes the top 20 original research studies and four practice guidelines of 2016, based on regular literature surveillance and as selected by members of the Canadian Medical Association. The studies, known as POEMs (patient-oriented evidence that matters), were rated highly because of their relevance, validity, and potential to change practice. Key hypertension treatment findings include reduced mortality (a benefit not demonstrated in lower-risk persons or persons with diabetes mellitus) but also an increase in harms with a more aggressive blood pressure target in high-risk persons with hypertension and without diabetes...
May 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/28486933/influence-of-chronic-azithromycin-treatment-on-the-composition-of-the-oropharyngeal-microbial-community-in-patients-with-severe-asthma
#15
Guido Lopes Dos Santos Santiago, Guy Brusselle, Kenny Dauwe, Pieter Deschaght, Chris Verhofstede, Dries Vaneechoutte, Ellen Deschepper, Paul Jordens, Guy Joos, Mario Vaneechoutte
BACKGROUND: This study of the oropharyngeal microbiome complements the previously published AZIthromycin in Severe ASThma (AZISAST) clinical trial, where the use of azithromycin was assessed in subjects with exacerbation-prone severe asthma. Here, we determined the composition of the oropharyngeal microbial community by means of deep sequencing of the amplified 16S rRNA gene in oropharyngeal swabs from patients with exacerbation-prone severe asthma, at baseline and during and after 6 months treatment with azithromycin or placebo...
May 10, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28479113/pharmacotherapy-for-non-cystic-fibrosis-bronchiectasis-results-from-an-ntm-info-research-patient-survey-and-the-bronchiectasis-and-ntm-research-registry
#16
MULTICENTER STUDY
Emily Henkle, Timothy R Aksamit, Alan F Barker, Jeffrey R Curtis, Charles L Daley, M Leigh Anne Daniels, Angela DiMango, Edward Eden, Kevin Fennelly, David E Griffith, Margaret Johnson, Michael R Knowles, Amy Leitman, Philip Leitman, Elisha Malanga, Mark L Metersky, Peadar G Noone, Anne E O'Donnell, Kenneth N Olivier, Delia Prieto, Matthias Salathe, Byron Thomashow, Gregory Tino, Gerard Turino, Susan Wisclenny, Kevin L Winthrop
BACKGROUND: Non-cystic fibrosis bronchiectasis ("bronchiectasis") is a chronic inflammatory lung disease often associated with nontuberculous mycobacteria (NTM) infection. Very little data exist to guide bronchiectasis management decisions. We sought to describe patterns of inhaled corticosteroid (ICS) and antibiotic therapy in the United States. METHODS: We invited 2,000 patients through NTM Info & Research (NTMir) to complete an anonymous electronic survey...
December 2017: Chest
https://www.readbyqxmd.com/read/28456910/microbes-and-the-role-of-antibiotic-treatment-for-wheezy-lower-respiratory-tract-illnesses-in-preschool-children
#17
REVIEW
Christina G Kwong, Leonard B Bacharier
PURPOSE OF REVIEW: Antibiotics are commonly used to treat wheezy lower respiratory tract illnesses in preschoolers, although these infections have been traditionally thought to be predominantly of viral origin. Our purpose is to review recent research pertaining to the role of antibiotics in lower respiratory tract illnesses and on subsequent asthma development, as well as the possible mechanisms of their effects. RECENT FINDINGS: Increasing evidence suggests that asthma pathogenesis is associated with events during infancy and early childhood, particularly respiratory tract infections...
May 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28415826/azithromycin-augments-rhinovirus-induced-ifn%C3%AE-via-cytosolic-mda5-in-experimental-models-of-asthma-exacerbation
#18
Mandy Menzel, Hamid Akbarshahi, Ellen Tufvesson, Carl Persson, Leif Bjermer, Lena Uller
Deficient production of anti-viral interferons (IFNs) may be involved in causing viral-induced asthma exacerbations. Hence, drugs inducing lung IFN production would be warranted. Azithromycin may reduce asthma exacerbations but its modus operandi is unknown. Here, we investigated if azithromycin induces IFNβ expression in vitro in rhinovirus-infected bronchial epithelial cells from asthmatic donors and in vivo in our allergic inflammation-based mouse model of viral stimulus-induced asthma exacerbations. Azithromycin dose-dependently augmented viral-induced IFNβ expression in asthmatic, but not in healthy bronchial epithelial cells...
May 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28258107/nonantibiotic-macrolides-restore-airway-macrophage-phagocytic-function-with-potential-anti-inflammatory-effects-in-chronic-lung-diseases
#19
Sandra Hodge, Hai B Tran, Rhys Hamon, Eugene Roscioli, Greg Hodge, Hubertus Jersmann, Miranda Ween, Paul N Reynolds, Arthur Yeung, Jennifer Treiberg, Sibylle Wilbert
We reported defective efferocytosis associated with cigarette smoking and/or airway inflammation in chronic lung diseases, including chronic obstructive pulmonary disease, severe asthma, and childhood bronchiectasis. We also showed defects in phagocytosis of nontypeable Haemophilus influenzae (NTHi), a common colonizer of the lower airway in these diseases. These defects could be substantially overcome with low-dose azithromycin; however, chronic use may induce bacterial resistance. The aim of the present study was therefore to investigate two novel macrolides-2'-desoxy-9-(S)-erythromycylamine (GS-459755) and azithromycin-based 2'-desoxy molecule (GS-560660)-with significantly diminished antibiotic activity against Staphylococcus aureus , Streptococcus pneumonia , Moraxella catarrhalis , and H...
May 1, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28118241/management-of-preschool-recurrent-wheezing-and-asthma-a-phenotype-based-approach
#20
REVIEW
Avraham Beigelman, Leonard B Bacharier
PURPOSE OF REVIEW: The purpose of this review is to summarize the recent evidence on the management of preschool children with wheezing and asthma, and to propose a phenotype-based approach to the management of these children. RECENT FINDINGS: Recent studies have begun to identify populations of preschool children that are likely to benefit from inhaled corticosteroids (ICS) therapy and defined ICS regimens: daily ICS in preschool children with persistent asthma, and pre-emptive high-dose intermittent ICS among preschool children with intermittent disease reduce the risk of exacerbation...
April 2017: Current Opinion in Allergy and Clinical Immunology
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