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https://www.readbyqxmd.com/read/29446846/histological-immune-response-patterns-in-sentinel-lymph-nodes-involved-by-metastatic-melanoma-and-prognostic-significance
#1
James Abbott, Meghan Buckley, Laura A Taylor, George Xu, Giorgos Karakousis, Brian J Czerniecki, Phyllis A Gimotty, Paul J Zhang
AIMS: To further characterize the micromorphometric immunological pattern to metastatic melanoma in SLN biopsies and completion lymph node (CLN) dissections and their relation to 5-year overall survival. METHODS: Retrospective cohort of 49 patients from 1996 to 2005 with a positive SLN who underwent CLN dissection were studied. Micromorphometric characteristics included: follicular center count per profile (FCC), sinus histiocytosis, metastatic size, tumor infiltrating lymphocytes (intranodal), paracortial dendritic cells, germinal center reaction, and morphology...
February 15, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29435284/18f-fluoro-2-deoxyglucose-positron-emission-computed-tomography-in-a-rare-cutaneous-form-of-rosai-dorfman-disease-a-case-report
#2
Joya Hadchiti, Francois G Kamar, Jean Abi Ghosn, Mohamad Haidar, Ahmad Younes, Antoine Obeid, Marwan Haddad, Fadi Farhat, Feras Chehade
Rosai-Dorfman disease (RDD), or sinus histiocytosis with massive lymphadenopathy, commonly involves the lymph nodes but may secondarily involve the skin. Purely cutaneous disease without lymphatics or internal organ involvement occurs rarely. The present report detailed a rare case of 18F-fluoro-2-deoxyglucose positron emission-computed tomography (18FDG PET-CT) performed in a 33-year-old male soldier with a purely cutaneous form of RDD. Staging with 18FDG PET-CT was ordered prior to excisional biopsies of the aforedescribed masses and pathology reported RDD...
February 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29431901/effects-of-fibroblast-myocyte-coupling-on-the-sinoatrial-node-activity-a-computational-study
#3
REVIEW
Alexey A Karpaev, Roman A Syunyaev, Rubin R Aliev
While the sinoatrial node (SAN) is structurally heterogeneous, the majority of computer simulations of electrical activity take into account SAN pacemaker cells only. Our aim was to investigate how fibroblasts affect the SAN activity. We simulated the rabbit sinoatrial node accounting for differences between central and peripheral pacemaker cells, and for fibroblast-myocyte electrical coupling. We have observed that only if fibroblast-myocyte coupling is taken into account 1) action potential is initiated in the central part of the SAN (within 1...
February 12, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29416876/histological-scoring-of-immune-and-stromal-features-in-breast-and-axillary-lymph-nodes-is-prognostic-for-distant-metastasis-in-lymph-node-positive-breast-cancers
#4
Anita Grigoriadis, Patrycja Gazinska, Trupti Pai, Sheeba Irhsad, Yin Wu, Rosemary Millis, Kalnisha Naidoo, Julie Owen, Cheryl E Gillett, Andrew Tutt, Anthonius Cc Coolen, Sarah E Pinder
The prognostic importance of lymph node (LN) status and tumour-infiltrating lymphocytes (TILs), is well established, particularly TILs in triple negative breast cancers (TNBCs). So far, few studies have interrogated changes in involved and uninvolved LNs and evaluated if their morphological patterns add valuable information for the prediction of disease progression in breast cancer. In a cohort of 309 patients enriched for TNBCs (170/309), we histologically characterised immune and stromal features in primary tumours and associated involved and uninvolved axillary LNs on routine haematoxylin and eosin stained sections...
January 2018: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/29401490/propionibacterium-acnes-derived-insoluble-immune-complexes-in-sinus-macrophages-of-lymph-nodes-affected-by-sarcoidosis
#5
Yoshimi Suzuki, Keisuke Uchida, Tamiko Takemura, Masaki Sekine, Tomoki Tamura, Asuka Furukawa, Akira Hebisawa, Yumi Sakakibara, Nobuyasu Awano, Tomonari Amano, Daisuke Kobayashi, Mariko Negi, Tomoya Kakegawa, Yuriko Wada, Takashi Ito, Takashige Suzuki, Takumi Akashi, Yoshinobu Eishi
BACKGROUND: Propionibacterium acnes is thought to be a causative agent of sarcoidosis. Patients with sarcoidosis have circulating immune complexes. We attempted to detect P. acnes-derived immune complexes in sarcoid lesions. METHODS: We evaluated formalin-fixed and paraffin-embedded lymph node samples from 38 sarcoidosis patients and 90 non-sarcoidosis patients (27 patients with necrotizing lymphadenitis, 28 patients with reactive lymphadenitis, 16 patients with colon cancer, 19 patients with gastric cancer) by immunohistochemistry using anti-human immunoglobulins (IgG, IgA, and IgM) and complement (C1q and C3c) antibodies, and a P...
2018: PloS One
https://www.readbyqxmd.com/read/29397525/coronary-sinus-morphology-in-pediatric-patients-with-supraventricular-tachycardia
#6
Matthew B Ambrose, Jennifer N Avari Silva, Michael Rudokas, Tammy M Bowman, Joshua Murphy, George F Van Hare
PURPOSE: The anatomic basis of atrioventricular node reentrant tachycardia (AVNRT) remains incompletely characterized in children. Differences in coronary sinus (CS) size and morphology have been observed in adults with AVNRT but have not been well characterized in children. METHODS: Children (< 18 years) brought to the EP lab with supraventricular tachycardia for ablation underwent CS venography. A blinded pediatric interventional cardiologist performed CS measurements, which were indexed to body surface area...
February 3, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/29393857/oscillatory-behavior-of-p-wave-duration-and-pr-interval-in-experimental-congestive-heart-failure-a-preliminary-study
#7
Gianfranco Piccirillo, Damiano Magrì, Gaetana D'Alessandro, Claudia Fiorucci, Federica Moscucci, Claudia Di Iorio, Fabiola Mastropietri, Ilaria Parrotta, Masahiro Ogawa, Shien-Fong Lin, Peng-Sheng Chen
The relationship between autonomic nervous system (ANS) modulation of the sinus node and heart rate variability has been extensively investigated. Current study sought to evaluate, in an animal experimental model of pacing-induced tachycardia congestive heart failure (CHF), a possible ANS influence on P wave duration and PR interval oscillations. Short term (5-minutes) time and frequency domain analysis has been obtained in six dogs for the following electrocardiographic intervals: P wave duration (P), from the onset to peak of P wave (Pp), from the onset of P wave to the q onset (PR) and from the end of P wave to the onset of q wave (PeR)...
February 2, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29381437/diagnosis-and-treatment-of-75-patients-with-idiopathic-lobular-granulomatous-mastitis
#8
Jieqing Li
Idiopathic granulomatous lobular matitis (IGLM) is a rare non-specific inflammatory disease of the breast. Although IGLM is completely benign, it is easily confused with cancer due to progressive breast lump with firmly unilateral and discrete mass, nipple retraction and sinus formation. Patients with IGLM are usually associated with inflammation of the overlying skin. This study aimed to investigate the clinical characteristics of IGLM, treatment options and prognosis. From January 2010 to February 2015, 75 IGLM patients in our hospital were included, with an average age of 35...
January 30, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29378967/neutrophils-recruited-through-high-endothelial-venules-of-the-lymph-nodes-via-pnad-intercept-disseminating-staphylococcus-aureus
#9
Ania Bogoslowski, Eugene C Butcher, Paul Kubes
Staphylococcus aureus is a skin- and respiratory tract-colonizing bacterium and is the leading cause of community-acquired skin infections. Dissemination of these bacteria into systemic circulation causes bacteremia, which has a high mortality rate. Therefore, understanding the immunologic barriers that prevent dissemination is critical to developing novel treatments. In this study, we demonstrate that an S. aureus breach across skin leads to some migration of the pathogen to the draining lymph node, but no further...
January 29, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29368640/co-localization-of-lymphoid-aggregates-and-lymphatic-networks-in-nose-nalt-and-lacrimal-duct-associated-lymphoid-tissue-ldalt-of-mice
#10
Melanie Lohrberg, Reinhard Pabst, Jörg Wilting
BACKGROUND: The lymphatic vascular pattern in the head of mice has rarely been studied, due to problems of sectioning and immunostaining of complex bony structures. Therefore, the association of head lymphoid tissues with the lymphatics has remained unknown although the mouse is the most often used species in immunology. RESULTS: Here, we studied the association of nasal and nasolacrimal duct lymphatics with lymphoid aggregates in 14-day-old and 2-month-old mice...
January 25, 2018: BMC Immunology
https://www.readbyqxmd.com/read/29368529/value-of-two-cycle-docetaxel-cisplatin-and-5-fluorouracil-induction-chemotherapy-in-hypopharyngeal-carcinoma
#11
X Luo, B Zhang, Z Lian, Y Dong, J Liu, S Pei, X Mo, L Zhang, W Huang, F Ouyang, B Guo, C Liang, S Zhang
Various studies have investigated laryngeal function and survival after induction chemotherapy in hypopharyngeal carcinoma, but potential factors to help predict response rates after induction chemotherapy remain unknown. This retro- spective study evaluated which factors are related to an ineffective response to two-cycle docetaxel, cisplatin, and 5-fluoro- uracil (TPF) induction chemotherapy in hypopharyngeal carcinoma to determine potential candidates for this treatment in clinical practice. From Jan 2005 to Dec 2015, 81 patients diagnosed with hypopharyngeal squamous cell carcinoma based on a pathological examination were analyzed...
January 25, 2018: Neoplasma
https://www.readbyqxmd.com/read/29367535/management-of-arrhythmias-in-heart-failure
#12
REVIEW
Daniele Masarone, Giuseppe Limongelli, Marta Rubino, Fabio Valente, Rossella Vastarella, Ernesto Ammendola, Rita Gravino, Marina Verrengia, Gemma Salerno, Giuseppe Pacileo
Heart failure patients are predisposed to develop arrhythmias. Supraventricular arrhythmias can exacerbate the heart failure symptoms by decreasing the effective cardiac output and their control require pharmacological, electrical, or catheter-based intervention. In the setting of atrial flutter or atrial fibrillation, anticoagulation becomes paramount to prevent systemic or cerebral embolism. Patients with heart failure are also prone to develop ventricular arrhythmias that can present a challenge to the managing clinician...
February 28, 2017: Journal of Cardiovascular Development and Disease
https://www.readbyqxmd.com/read/29345729/sinus-node-dysfunction-after-heart-transplantation-how-much-pacing-is-required
#13
Florian Ernst Martin Herrmann, Petra Wellmann, Sebastian Sadoni, René Schramm, Christian Hagl, Gerd Juchem
INTRODUCTION: We investigated the development of sinus node dysfunction (SND) requiring pacemaker implantation after heart transplant (HTx) especially regarding pacing burden in these patients. PATIENTS AND METHODS: Patients requiring a pacemaker for SND were compared to all other patients in an HTx cohort including transplant patients from 1981-2016. RESULTS: SND requiring pacemaker implantation developed in 118 patients (10%). These patients had received a biatrial anastomosis more frequently than those in the No SND group 95...
January 18, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29322518/pediatric-heart-transplantation-what-are-the-risk-factors-for-pacemaker-implantation-and-how-much-pacing-is-required
#14
Florian Ernst Martin Herrmann, Petra Wellmann, Christian Hagl, Gerd Juchem
BACKGROUND: In an attempt to improve pacemaker therapy after pediatric transplantation we investigated risk factors, indication for pacing and pacing burden after pediatric heart transplantation. METHODS AND RESULTS: In this retrospective study 139 pediatric heart transplant recipients of which 122 did not and 17 did require pacemakers were investigated. Eleven of the 17 patients requiring a permanent pacemaker (PPM) received their heart from a female donor (68...
January 11, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29319271/sinus-node-dysfunction-a-rare-side-effect-of-tigecyclin
#15
Mukta Agarwal, Divendhu Bhushan
No abstract text is available yet for this article.
October 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29315578/hcn4-pacemaker-channels-attenuate-the-parasympathetic-response-and-stabilize-the-spontaneous-firing-of-sinoatrial-node
#16
Yuko Kozasa, Noriyuki Nakashima, Masayuki Ito, Taisuke Ishikawa, Hiroki Kimoto, Kazuo Ushijima, Naomasa Makita, Makoto Takano
The heart rate is dynamically controlled by the sympathetic and parasympathetic nervous systems that regulate the sinoatrial node (SAN). HCN4 pacemaker channels are well-known causative molecule of congenital sick sinus syndrome. Although HCN4 channels are activated by cAMP, the sympathetic response of SAN was preserved in the patients carrying loss-of-function mutations of HCN4 gene. In order to clarify the contribution of HCN4 channels in the autonomic regulation of SAN, we developed novel gain-of-function mutant mice in which expression level of HCN4 channels could be reversibly changed from zero to ∼3 times of that in wild type mice, using tetracycline trans-activator and tetracycline responsive element...
January 9, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29284434/clinicopathological-factors-influencing-the-outcomes-of-surgical-treatment-in-patients-with-t4a-hypopharyngeal-cancer
#17
Sang-Yeon Kim, Young-Soo Rho, Eun-Chang Choi, Min-Sik Kim, Joo-Hyun Woo, Dong Hoon Lee, Eun Jae Chung, Min Woo Park, Da-Hee Kim, Young-Hoon Joo
BACKGROUND: The purpose of this study was to determine prognostic factors influencing outcomes of surgical treatment in patients with T4a hypopharyngeal cancer. METHODS: The present study enrolled 93 patients diagnosed with T4a hypopharyngeal cancer who underwent primary surgery between January 2005 and December 2015 at six medical centers in Korea. Primary tumor sites included pyriform sinus in 71 patients, posterior pharyngeal wall in 14 patients, and postcricoid region in 8 patients...
December 29, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29281682/overexpression-of-map3k7-activates-sinoatrial-node-like-differentiation-in-mouse-es-derived-cardiomyocytes
#18
Kemar Brown, Stephanie Legros, Francis A Ortega, Yunkai Dai, Michael Xavier Doss, David J Christini, Richard B Robinson, Ann C Foley
In vivo, cardiomyocytes comprise a heterogeneous population of contractile cells defined by unique electrophysiologies, molecular markers and morphologies. The mechanisms directing myocardial cells to specific sub-lineages remain poorly understood. Here we report that overexpression of TGFβ-Activated Kinase (TAK1/Map3k7) in mouse embryonic stem (ES) cells faithfully directs myocardial differentiation of embryoid body (EB)-derived cardiac cells toward the sinoatrial node (SAN) lineage. Most cardiac cells in Map3k7-overexpressing EBs adopt markers, cellular morphologies, and electrophysiological behaviors characteristic of the SAN...
2017: PloS One
https://www.readbyqxmd.com/read/29280096/management-of-bradyarrhythmias-in-heart-failure-a-tailored-approach
#19
Daniele Masarone, Ernesto Ammendola, Anna Rago, Rita Gravino, Gemma Salerno, Marta Rubino, Tommaso Marrazzo, Antonio Molino, Paolo Calabrò, Giuseppe Pacileo, Giuseppe Limongelli
Patients with heart failure (HF) may develop a range of bradyarrhythmias including sinus node dysfunction, various degrees of atrioventricular block, and ventricular conduction delay. Device implantation has been recommended in these patients, but the specific etiology should be sought as it may influence the choice of the type of device required (pacemaker vs. implantable cardiac defibrillator). Also, pacing mode must be carefully set in patients with heart failure (HF) and left ventricular systolic dysfunction...
December 27, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29277685/cardiac-rhythm-and-pacemaking-abnormalities-in-patients-affected-by-endemic-pemphigus-in-colombia-may-be-a-result-of-deposition-of-autoantibodies-complement-fibrinogen-and-other-molecules
#20
Ana Maria Abreu Velez, Michael S Howard, Jorge Enrique Velazquez-Velez
BACKGROUND: We showed that one third of the patients affected by endemic pemphigus foliaceus in El Bagre, Colombia (El Bagre-EPF) display autoreactivity to the heart. OBJECTIVE: We aim to investigate rhythm disturbances with presence of autoantibodies and correlate them with electrocardiographic changes in these patients. METHODS: We performed a study comparing 30 patients and 30 controls from the endemic area, matched by demographics including age, sex and weight; work activities, comorbidities, among other variables...
December 22, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
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