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https://www.readbyqxmd.com/read/28101990/a-single-centre-study-of-1779-heart-transplant-patients-factors-affecting-pacemaker-implantation
#1
P Wellmann, F E M Herrmann, C Hagl, G Juchem
BACKGROUND: After around 10 % of heart transplants patients require pacemaker implantation. The bradyarrhythmias causing pacemaker requirement include sinus node dysfunction (SND) and atrioventricular block (AVB). This study sought to define clinical predictors for pacemaker requirement as well as identify differences in the patient groups developing SND and AVB. METHODS: Our operative data base was used to collect retrospective recipient, donor and operative data of all patients receiving orthotopic heart transplants between 1981 and 2016...
January 19, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28089877/permanent-pacemaker-implantation-in-octogenarians-with-unexplained-syncope-and-positive-electrophysiologic-study
#2
Georgios Giannopoulos, Charalampos Kossyvakis, Vasiliki Panagopoulou, Dimitrios Tsiachris, Konstantinos Doudoumis, Maria Mavri, Dimitrios Vrachatis, Konstantinos Letsas, Michael Efremidis, Apostolos Katsivas, John Lekakis, Spyridon Deftereos
BACKGROUND: Syncope is a common problem among the elderly and a permanent pacemaker is a therapeutic option when a bradycardic etiology is revealed. However, the benefit of pacing when no association of symptoms to bradycardia has been shown is not clear, especially in the elderly OBJECTIVES: Aim of this study was to evaluate the effect of pacing on syncope-free mortality in patients ≥80 years old, with unexplained syncope and positive invasive electrophysiologic testing (EPS). METHODS: This was an observational study...
January 12, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28086882/differential-effects-of-glucagon-like-peptide-1-receptor-agonists-on-heart-rate
#3
REVIEW
Martin Lorenz, Francesca Lawson, David Owens, Denis Raccah, Christine Roy-Duval, Anne Lehmann, Riccardo Perfetti, Lawrence Blonde
While glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are known to increase heart rate (HR), it is insufficiently recognized that the extent varies greatly between the various agonists and is affected by the assessment methods employed. Here we review published data from 24-h time-averaged HR monitoring in healthy individuals and subjects with type 2 diabetes mellitus (T2DM) treated with either short-acting GLP-1 RAs, lixisenatide or exenatide, or long-acting GLP-1 RAs, exenatide LAR, liraglutide, albiglutide, or dulaglutide (N = 1112; active-treatment arms)...
January 13, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28086779/the-effect-of-electrical-conductivity-of-myocardium-on-cardiac-pumping-efficacy-a-computational-study
#4
Ana Rahma Yuniarti, Ki Moo Lim
BACKGROUND AND AIMS: The existence of non-excitable cells in the myocardium leads to the increasing conduction non-uniformity and decreasing myocardial electrical conductivity. Slowed myocardial conduction velocity (MCV) believed to enhance the probability of cardiac arryhthmia and alter the cardiac mechanical pumping efficacy, even in sinus rhythm. Though several studies on the correlation between MCV and cardiac electrical instabilities exist, there has been no study concerning correlation or causality between MCV and cardiac mechanical pumping efficacy, due to the limitation in clinical methods to document and evaluate cardiac mechanical responses directly...
January 10, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28075105/heart-failure-due-to-reduced-ejection-fraction-medical-management
#5
William E Chavey, Robrt V Hogikyan, R Van Harrison, John M Nicklas
Heart failure is an increasingly common condition resulting in high rates of morbidity and mortality. For patients who have heart failure and reduced ejection fraction, randomized clinical trials demonstrate consistent mortality benefit from angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, direct-acting vasodilators, beta blockers, and aldosterone antagonists. Additionally, some data show benefits from two new classes of drugs: angiotensin receptor blocker/neprilysin inhibitor and sinus node modulator...
January 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/28058479/electrocardiographic-rr-and-qt-interval-variability-in-patients-with-atrial-septal-defect-and-healthy-children
#6
Yoshihiko Eryu, Tadayoshi Hata, Arisa Nagatani, Yuri Funamoto, Hidetoshi Uchida, Masayuki Fujino, Hiroko Boda, Masafumi Miyata, Tetsushi Yoshikawa
Atrial septal defect is a common congenital heart disease. In patients with atrial septal defect, left-to-right shunting increases the right atrial and right ventricular preload. This pathological change affects sinus node automaticity and myocardial depolarization and repolarization, and has the potential to evoke arrhythmogenic substrates. We examined the effect of atrial septal defect on sinus node automaticity and myocardial repolarization by investigating the variability in the repolarization interval, namely the QT variability index (QTVI) and variability ratio (VR)...
January 5, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28040461/the-micra-leadless-transcatheter-pacemaker-implantation-and-mid-term-follow-up-results-in-a-single-center
#7
José Luis Martínez-Sande, Javier García-Seara, Moisés Rodríguez-Mañero, Xesús Alberte Fernández-López, Laila González-Melchor, Alfredo Redondo-Diéguez, Rocío González-Ferreiro, José Ramón González-Juanatey
INTRODUCTION AND OBJECTIVES: Currently, studies on the leadless pacemaker (Micra) have mostly been limited to clinical trials with less than 6 months' follow-up and they often fail to reflect real population outcomes. We sought to evaluate electrical parameters at implantation and chronologically during follow-up, as well as the safety of this new technique. METHODS: This prospective, observational study included 30 consecutive patients, all ≥ 65 years, with an indication for single-chamber pacemaker implantation...
December 28, 2016: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28039178/the-natural-history-and-patterns-of-metastases-from-mucosal-melanoma-an-analysis-of-706-prospectively-followed-patients
#8
B Lian, C L Cui, L Zhou, X Song, X S Zhang, D Wu, L Si, Z H Chi, X N Sheng, L L Mao, X Wang, B X Tang, X Q Yan, Y Kong, J Dai, S M Li, X Bai, N Zheng, Charles M Balch, J Guo
BACKGROUND: We examined whether mucosal melanomas are different in their clinical course and patterns of metastases when arising from different anatomic sites. Our hypothesis was that metastatic behavior would differ from primary mucosal melanomas at different anatomical sites. PATIENTS AND METHODS: Clinical and pathological data from 706 patients were compared for their stage distribution, patterns of metastases, CKIT/BRAF mutation status, and overall survival for different anatomical sites...
December 29, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28038720/prevalence-and-characterization-of-coronary-artery-disease-in-patients-with-symptomatic-bradyarrhythmias-requiring-pacemaker-implantation
#9
Mohammad S Alai, Jahangir Rashid Beig, Sanjay Kumar, Irfan Yaqoob, Imran Hafeez, Ajaz A Lone, Mohammad Iqbal Dar, Hilal A Rather
BACKGROUND: This study was conducted to assess the prevalence and characterization of CAD in high risk patients requiring pacemaker implantation for symptomatic bradyarrhythmias. METHODS: This study included 100 patients with symptomatic sinus node dysfunction or atrioventricular block, who were at high risk of CAD or had previously documented atherosclerotic vascular disease (ASCVD). Coronary angiography was performed before pacemaker implantation. CAD was defined as the presence of any degree of narrowing in at least one major coronary artery or its first order branch...
December 2016: Indian Heart Journal
https://www.readbyqxmd.com/read/28036019/lymph-nodes-and-cancer-metastasis-new-perspectives-on-the-role-of-intranodal-lymphatic-sinuses
#10
REVIEW
Rui-Cheng Ji
The lymphatic system is essential for transporting interstitial fluid, soluble antigen, and immune cells from peripheral tissues to lymph nodes (LNs). Functional integrity of LNs is dependent on intact lymphatics and effective lymph drainage. Molecular mechanisms that facilitate interactions between tumor cells and lymphatic endothelial cells (LECs) during tumor progression still remain to be identified. The cellular and molecular structures of LNs are optimized to trigger a rapid and efficient immune response, and to participate in the process of tumor metastasis by stimulating lymphangiogenesis and establishing a premetastatic niche in LNs...
December 28, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28032928/integrity-of-the-ganglionated-plexi-is-essential-to-parasympathetic-innervation-of-the-atrioventricular-node-by-the-right-vagus-nervez
#11
Olivier Xhaet, Luc DE Roy, Mariana Floria, Olivier Deceuninck, Dominique Blommaert, Fabien Dormal, Elisabeth Ballant, Mark LA Meir
INTRODUCTION: Radiofrequency isolation of pulmonary vein can be accompanied by transient sinus bradycardia or atrioventricular nodal (AVN) block, suggesting an influence on vagal cardiac innervation. However, the importance of the atrial fat pads in relation with the vagal innervation of AVN in humans remains largely unknown. This article is protected by copyright. All rights reserved The aim of this study was to evaluate the role of ganglionated plexi (GP) in the innervation of the AVN by the right vagus nerve...
December 29, 2016: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28032679/acr-appropriateness-criteria-%C3%A2-nasal-cavity-and-paranasal-sinus-cancers
#12
Farzan Siddiqui, Richard V Smith, Sue S Yom, Jonathan J Beitler, Paul M Busse, Jay S Cooper, Ehab Y Hanna, Christopher U Jones, Shlomo A Koyfman, Harry Quon, John A Ridge, Nabil F Saba, Francis Worden, Min Yao, Joseph K Salama
The American College of Radiology (ACR) Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision include an extensive analysis of current medical literature from peer-reviewed journals and the application of well-established methodologies (RAND/UCLA Appropriateness Method and Grading of Recommendations Assessment, Development, and Evaluation or GRADE) to rate the appropriateness of imaging and treatment procedures for specific clinical scenarios...
December 29, 2016: Head & Neck
https://www.readbyqxmd.com/read/28028980/normal-values-for-heart-electrophysiology-parameters-of-healthy-swine-determined-on-electrophysiology-study
#13
Agnieszka Noszczyk-Nowak, Alicja Cepiel, Adrian Janiszewski, Robert Pasławski, Jacek Gajek, Urszula Pasławska, Józef Nicpoń
BACKGROUND: Swine are a well-recognized animal model for human cardiovascular diseases. Despite the widespread use of porcine model in experimental electrophysiology, still no reference values for intracardiac electrical activity and conduction parameters determined during an invasive electrophysiology study (EPS) have been developed in this species thus far. OBJECTIVES: The aim of the study was to develop a set of normal values for intracardiac electrical activity and conduction parameters determined during an invasive EPS of swine...
November 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28017340/feline-respiratory-extramedullary-plasmacytoma-with-lymph-node-metastasis-and-intrahistiocytic-amyloid
#14
S E Sykes, V Byfield, L Sullivan, S J Bender, P F Moore, M D Sánchez
A 14-year-old domestic longhaired cat presented with a 2-year history of nasal discharge and a recent onset of inappetence and submandibular lymphadenopathy. The cat was humanely destroyed after developing severe respiratory distress. Necropsy examination revealed thickened nasal turbinates and soft palate, and friable red-tan material within the frontal sinus, nasal cavity and nasopharynx. The lungs contained multifocal irregular friable tan nodules. Multiple lymph nodes were enlarged, friable and red-tan in colour...
December 22, 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28011797/reappraisal-and-new-observations-on-atrial-tachycardia-ablated-from-the-non-coronary-aortic-sinus-of-valsalva
#15
Shomu Bohora, Yash Lokhandwala, Eduardo Back Sternick, Robert H Anderson, Hein J J Wellens
AIMS: The clinical characteristics of atrial tachycardias (AT) ablated from the non-coronary aortic sinus (NCS) are thus far described only in small series. We aimed to outline, in a large cohort of patients, the clinical, electrocardiographic, electrophysiological characteristics of this tachycardia. METHODS AND RESULTS: We analysed data pertaining to clinical, electrocardiographic, and electrophysiological characteristics of 43 consecutive patients from an overall cohort of 441 with AT who were successfully ablated from the NCS...
December 23, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28007062/rescuing-the-late-failing-fontan-focus-on-surgical-treatment-of-dysrhythmias
#16
REVIEW
Carl L Backer
Patients with a failing Fontan frequently have dysrhythmias. This review will focus on the treatment of those dysrhythmias based on the 140 patients who have had a Fontan conversion with arrhythmia surgery at Ann & Robert H. Lurie Children's Hospital of Chicago (Chicago, IL). Important technical points to be emphasized are the following:• Atrial fibrillation is extremely common in patients with a failing Fontan and strong consideration should be given to a Cox-maze III during any Fontan conversion• Sinus node dysfunction is common post-conversion and all patients should receive a dual-chamber epicardial pacemaker• Careful preoperative imaging with either computed tomographic or magnetic resonance imaging is needed to predict re-entry problems at the time of repeat sternotomy• If the patient has protein-losing enteropathy, ascites, or a right or indeterminate ventricular morphology, strong consideration should be given to heart transplantation rather than a Fontan conversion and arrhythmia surgery...
January 2017: Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual
https://www.readbyqxmd.com/read/28002629/possible-functions-of-cd169-positive-sinus-macrophages-in-lymph-nodes-in-anti-tumor-immune-responses
#17
REVIEW
Yoshihiro Komohara, Koji Ohnishi, Motohiro Takeya
The lymph node (LN) is an important immune system in which a number of antigen-presenting cells (APCs) are present that induce rapid immune responses to foreign antigens. While a great number of macrophages exist in lymph nodes, recent studies using animal models have shown that lymph node sinus macrophages are associated with the induction of anti-tumor immunity, playing a significant role in host immune responses against tumor cells. In colorectal tumor, malignant melanoma, and endometrial tumor, it was shown that a high density of CD169-positive macrophages in the LN sinus was a predictive factor for better clinical prognosis...
December 21, 2016: Cancer Science
https://www.readbyqxmd.com/read/27989053/conventional-and-novel-predictors-of-permanent-pacemaker-after-tavi-in-atrial-fibrillation-patients
#18
Guilherme Portugal, Lino Patrício, Ana Abreu, Duarte Cacela, Mário Oliveira, Rui Ferreira
BACKGROUND: Atrial fibrillation (AF) is common in patients submitted for transcatheter aortic valve implantation (TAVI), and these patients are at higher risk of developing conduction system disturbances requiring pacemaker (PM) implantation. Conventional predictors for PM use in this population have limited applicability. It was hypothesized that a post-procedural heart rate reduction could gauge the degree of atrioventricular (AV) node injury, and that this would be a clinically useful predictor of a need for PM...
May 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/27958616/the-effect-of-atrial-pacing-site-on-electrophysiological-properties-of-the-atrioventricular-junction-and-induction-of-atrioventricular-nodal-reentry-in-patients-with-typical-atrioventricular-nodal-reentrant-tachycardia
#19
Radosław Marek Kiedrowicz, Jarosław Kaźmierczak, Maciej Wielusiński
BACKGROUND: Clinical studies in humans have shown the site of atrial stimulation to influence atrioventricular (AV) conduction times and refractory periods, the demonstration of dual atrioventricular nodal (AVN) pathways and induction of AVN reentry. These studies often found conflicting results. Moreover among enrolled patients the minority of them were found to have atrioventricular nodal reentrant tachycardia (AVNRT). The purpose of this study was to investigate the effect of the right and left atrial pacing on electrophysiological properties of the AV junction in the typical AVNRT population...
December 13, 2016: Kardiologia Polska
https://www.readbyqxmd.com/read/27926941/type-1-interferons-and-nk-cells-limit-murine-cytomegalovirus-escape-from-the-lymph-node-subcapsular-sinus
#20
Helen E Farrell, Kimberley Bruce, Clara Lawler, Rhonda D Cardin, Nicholas J Davis-Poynter, Philip G Stevenson
Cytomegaloviruses (CMVs) establish chronic, systemic infections. Peripheral infection spreads via lymph nodes, which are also a focus of host defence. Thus, this is a point at which systemic infection spread might be restricted. Subcapsular sinus macrophages (SSM) captured murine CMV (MCMV) from the afferent lymph and poorly supported its replication. Blocking the type I interferon (IFN-I) receptor (IFNAR) increased MCMV infection of SSM and of the fibroblastic reticular cells (FRC) lining the subcapsular sinus, and accelerated viral spread to the spleen...
December 2016: PLoS Pathogens
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