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https://www.readbyqxmd.com/read/28454112/the-challenge-of-treating-hepatitis-c-virus-associated-cryoglobulinemic-vasculitis-in-the-era-of-anti-cd20-monoclonal-antibodies-and-direct-antiviral-agents
#1
REVIEW
Dario Roccatello, Savino Sciascia, Daniela Rossi, Laura Solfietti, Roberta Fenoglio, Elisa Menegatti, Simone Baldovino
Mixed cryoglobulinemia syndrome (MC) is a systemic vasculitis involving kidneys, joints, skin, and peripheral nerves. While many autoimmune, lymphoproliferative, and neoplastic disorders have been associated with this disorder, hepatitis C virus (HCV) is known to be the etiologic agent in the majority of patients. Therefore, clinical research has focused on anti-viral drugs and, more recently, on the new, highly potent Direct-acting Antiviral Agents (DAAs). These drugs assure sustained virologic response (SVR) rates >90%...
April 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454100/a-mathematical-theory-of-the-transcription-repression-tr-therapy-of-cancer-whether-and-how-it-may-work
#2
Yuxin Chen, Haijun Wen, Chung-I Wu
Transcription repression (TR) therapy of cancer has been widely discussed. Here, TR refers to global repression of transcription rather than specific targeting of cancer-causing genes such as MYC. TR drugs inhibit transcription by binding to the transcribed DNA or to RNA polymerase; for example, actinomycin D has been extensively used in research and therapy to shut down transcription globally [1-7]. As proliferating cells demand a high rate of transcription, restricting transcript production could be effective in slowing down cell proliferation...
April 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28453850/a-novel-ligand-of-toll-like-receptor-4-from-the-sheath-of-wuchereria-bancrofti-microfilaria-induces-proinflammatory-response-in-macrophages
#3
Suprabhat Mukherjee, Sandip Mukherjee, Tushar K Maiti, Samir Bhattacharya, Santi P Sinha Babu
Background.: Lymphatic filariasis, frequently caused from Wuchereria bancrofti infection, is endemic in several parts of the globe and responsible for human health problems and socioeconomic loss to a large extent. Inflammatory consequences originating from host-parasite interaction play a major role in the disease pathology and allied complications. The identity of the key mediator of this process is yet unknown in filarial research. Methods.: Microfilarial protein (MfP) was isolated from the sheath of W...
March 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28453790/does-the-law-on-compensation-for-research-related-injury-in-the-uk-australia-and-new-zealand-meet-ethical-requirements
#4
Joanna M Manning
Despite a consensus that society owes an ethical obligation to compensate for research-related injury, and that no-fault is the best ethical response, an assessment of the compensation arrangements in place in the UK, Australia and New Zealand shows that in general compensation arrangements fall below this ethical expectation. Most subjects rely on ex gratia payment or an unenforceable assurance of payment in the event of injury. It is also likely that, given significant deficiencies in participant information about compensation arrangements in place for trials recommended by the supervisory ethics agencies in each jurisdiction, subjects only find out about their financial exposure in the event of injury...
April 26, 2017: Medical Law Review
https://www.readbyqxmd.com/read/28453773/increased-cerebrospinal-fluid-levels-of-gaba-testosterone-and-estradiol-in-women-with-polycystic-ovary-syndrome
#5
Jennifer F Kawwass, Kristen M Sanders, Tammy L Loucks, Lisa Cencia Rohan, Sarah L Berga
STUDY QUESTION: Do cerebrospinal fluid (CSF) concentrations of gamma-aminobutyric acid (GABA), testosterone (T) and estradiol (E2) differ in women with polycystic ovary syndrome (PCOS) as compared to eumenorrheic, ovulatory women (EW)? SUMMARY ANSWER: Women with PCOS displayed higher CSF levels of GABA and E2, and possibly T, than EW. WHAT IS KNOWN ALREADY: The chronic anovulation characteristic of PCOS has been attributed to increased central GnRH drive and resulting gonadotropin aberrations...
April 27, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28453675/circosvcf-circos-visualization-of-whole-genome-sequence-variations-stored-in-vcf-files
#6
E Drori, D Levy, P Smirin-Yosef, O Rahimi, M Salmon-Divon
Summary: Visualization of whole-genomic variations in a meaningful manner assists researchers in gaining new insights into the underlying data, especially when it comes in the context of whole genome comparisons. CircosVCF is a web based visualization tool for genome-wide variant data described in VCF files, using circos plots. The user friendly interface of CircosVCF supports an interactive design of the circles in the plot, and the integration of additional information such as experimental data or annotations...
May 1, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28453668/a-mass-graph-based-approach-for-the-identification-of-modified-proteoforms-using-top-down-tandem-mass-spectra
#7
Qiang Kou, Si Wu, Nikola Tolic, Ljiljana Paša-Tolic, Yunlong Liu, Xiaowen Liu
Motivation: Although proteomics has rapidly developed in the past decade, researchers are still in the early stage of exploring the world of complex proteoforms, which are protein products with various primary structure alterations resulting from gene mutations, alternative splicing, post-translational modifications, and other biological processes. Proteoform identification is essential to mapping proteoforms to their biological functions as well as discovering novel proteoforms and new protein functions...
May 1, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28453622/the-impact-of-exercise-on-cancer-mortality-recurrence-and-treatment-related-adverse-effects
#8
Prue Cormie, Eva M Zopf, Xiaochen Zhang, Kathryn H Schmitz
The combination of an increasing number of new cancer cases and improving survival rates has led to a large and rapidly growing population with unique health-care requirements. Exercise has been proposed as a strategy to help address the issues faced by cancer patients. Supported by a growing body of research, major health organizations commonly identify the importance of incorporating exercise in cancer care and advise patients to be physically active. This systematic review comprehensively summarizes the available epidemiologic and randomized controlled trial evidence investigating the role of exercise in the management of cancer...
April 27, 2017: Epidemiologic Reviews
https://www.readbyqxmd.com/read/28453588/-diverticular-disease-myths-and-realities
#9
Daniela Fluxá, Rodrigo Quera
Diverticulosis and diverticular disease of the colon are common conditions in Western countries. The incidence and prevalence of these diseases are increasing and becoming significant for health systems. A growing body of knowledge is shifting the paradigm of the pathogenesis and treatment of diverticular disease. Low-grade inflammation, altered intestinal microbiota, visceral hypersensitivity, and abnormal colonic motility have been identified as factors leading to diverticular disease. The risk of developing diverticulitis among individuals with diverticulosis is lower than 10 to 25%...
February 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28453547/a-systematic-review-of-hybrid-brain-computer-interfaces-taxonomy-and-usability-perspectives
#10
Inchul Choi, Ilsun Rhiu, Yushin Lee, Myung Hwan Yun, Chang S Nam
A new Brain-Computer Interface (BCI) technique, which is called a hybrid BCI, has recently been proposed to address the limitations of conventional single BCI system. Although some hybrid BCI studies have shown promising results, the field of hybrid BCI is still in its infancy and there is much to be done. Especially, since the hybrid BCI systems are so complicated and complex, it is difficult to understand the constituent and role of a hybrid BCI system at a glance. Also, the complicated and complex systems make it difficult to evaluate the usability of the systems...
2017: PloS One
https://www.readbyqxmd.com/read/28453501/measuring-alcohol-marketing-engagement-the-development-and-psychometric-properties-of-the-alcohol-marketing-engagement-scale
#11
Angela Robertson, David T Morse, Kristina Hood, Courtney Walker
Ample evidence exists in support of the influence of media, both traditional and electronic, on perceptions and engagement with alcohol marketing. We describe the development, calibration, and evidence for technical quality and utility for a new measure, the Alcohol Marketing Engagement Scale. Using two samples of college undergraduates (n1 = 199, n2 = 732), we collected field test responses to a total of 13 items. Initial support for scale validity is presented via correlations with attributes previously shown to be related to alcohol engagement...
2017: Journal of Applied Measurement
https://www.readbyqxmd.com/read/28453416/nurse-research-rounds-in-the-spirit-of-inquiry
#12
Wanda S Thomas
Nurses deliver a point-of-care service to patients. The nursing staff work extensive schedules and do not have time to research a clinical question to help support patient care. This article describes the implementation of the first research service that supports evidence-based practice at Georgia's second largest hospital. Inspired by a similar service at a children's hospital in 2014, the first year of nurse research rounds provides clinicians a new research service in their clinical setting.
April 2017: Medical Reference Services Quarterly
https://www.readbyqxmd.com/read/28453368/establishment-of-expanded-and-streamlined-pipeline-of-pitch-knock-in-a-web-based-design-tool-for-mmej-mediated-gene-knock-in-pitch-designer-and-the-variations-of-pitch-pitch-tg-and-pitch-kiko
#13
Kazuki Nakamae, Yuki Nishimura, Mitsumasa Takenaga, Shota Nakade, Naoaki Sakamoto, Hiroshi Ide, Tetsushi Sakuma, Takashi Yamamoto
The emerging genome editing technology has enabled the creation of gene knock-in cells easily, efficiently, and rapidly, which has dramatically accelerated research in the field of mammalian functional genomics, including in humans. We recently developed a microhomology-mediated end-joining-based gene knock-in method, termed the PITCh system, and presented various examples of its application. Since the PITCh system only requires very short microhomologies (up to 40 bp) and single-guide RNA target sites on the donor vector, the targeting construct can be rapidly prepared compared with the conventional targeting vector for homologous recombination-based knock-in...
April 28, 2017: Bioengineered
https://www.readbyqxmd.com/read/28453365/a-novel-method-for-designing-and-optimizing-the-layout-of-facilities-in-bathroom-for-the-elderly-in-home-based-rehabilitation
#14
Duojin Wang, Jing Wu, Qinglian Lin
PURPOSE: The home-based rehabilitation of elderly patients improves their autonomy, independence and reintegration into society. Hence, a suitable environment plays an important role in rehabilitation, as do different assistance technologies. The majority of accidents at home involving elderly people occur in the bathroom. Therefore, the planning of the layout of facilities is important in this potentially dangerous area. This paper proposes an approach towards designing and optimizing the layout of facilities in the bathroom, based on logistical and nonlogistical relationships...
April 28, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/28453275/dielectric-response-of-cytoplasmic-water-and-its-connection-to-the-vitality-of-human-red-blood-cells-ii-the-influence-of-storage
#15
Evgeniya Levy, Marcelo David, Gregory Barshtein, Saul Yedgar, Leonid Livshits, Paul Ben Ishai, Yuri Feldman
Maintaining an appropriate inventory of packaged blood products is a critical part of modern medicine. Consequently, the assessment of red blood cell (RBC) functionality is instrumental for the monitoring of the quality of stored RBC (sRBC) in the blood bank. We present a comprehensive study of sRBC lesion kinetics in SAGM (Saline, Adenine, Glucose, Mannitol) solution, using microwave dielectric spectroscopy (0.5 GHz - 50 GHz) and cell deformability. As part of the research we have isolated the microwave dielectric response of cytoplasmic water in sRBC...
April 28, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28453273/half-metallicity-in-one-dimensional-metal-trihydride-molecular-nanowires
#16
Xiuling Li, Haifeng Lv, Jun Dai, Liang Ma, Xiao Cheng Zeng, Xiaojun Wu, Jinlong Yang
The development of one-dimensional (1D) molecular nanowires with high spin-polarization is important for both fundamental research and practical applications in nanoscale spintronics. Herein, we report new 1D metal trihydride molecular nanowires MH3 (M=Sc, Cr, Mn, and Co) with versatile magnetic properties on the basis of first-principles calculations and molecular assembly of their molecular motifs. Among the 1D nanowires considered, CrH3, MnH3, and CoH3 are either antiferromagnetic or ferromagnetic in their ground states...
April 28, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28450127/carcinogenicity-of-consumption-of-red-meat-and-processed-meat-a-review-of-scientific-news-since-the-iarc-decision
#17
REVIEW
José L Domingo, Martí Nadal
In October 2015, the International Agency for Research on Cancer (IARC) issued a press release on the results of the evaluation of the carcinogenicity of red and processed meat. Based on the accumulated scientific literature, the consumption of red meat was classified as "probably carcinogenic to humans" and processed meat as "carcinogenic to humans". Given the importance of this topic, this review was aimed at revising the current state-of-the-art on the carcinogenicity of red and processed meat, some time after the IARC decision...
April 24, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28449529/do-hospitals-need-oncological-critical-care-units
#18
EDITORIAL
Abby Koch, William Checkley
Since the inception of critical care as a formal discipline in the late 1950s, we have seen rapid specialization to many types of intensive care units (ICUs) to accommodate evolving life support technologies and novel therapies in various disciplines of medicine. Indeed, the field has expanded such that specialized ICUs currently exist to address critical care problems in medicine, cardiology, neurology and neurosurgery, trauma, burns, organ transplant and cardiothoracic surgeries. Specialization does not only need new infrastructure, but also training and staffing of health care providers, ancillary staff, and development and implementation of processes of care...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28449469/cd90-positive-cells-exhibit-aggressive-radioresistance-in-esophageal-squamous-cell-carcinoma
#19
Yuandong Wang, Chi Zhang, Hongcheng Zhu, Junwei Tang, Shu Zhang, Jinhua Luo, Xinchen Sun
BACKGROUND: Cancer stem cells (CSCs) are widely abundant and considered to be an important factor in therapy resistance. They are also promising potential targets for conquering tumors. We explored the effects of radiation on stem cell-like tumor cells via the candidate marker CD90 to provide new ideas for the comprehensive treatment of esophageal squamous cell carcinoma (ESCC). METHODS: We constructed CD90 overexpression ESCC cells by lentiviral transfection and observed differences of toxicity, proliferation, clone number, apoptosis, migration, invasion, and in vivo tumor formation after irradiation...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28449400/a-novel-implementation-strategy-in-residential-care-settings-to-promote-ebp-direct-care-provider-perceptions-and-development-of-a-conceptual-framework
#20
Susan E Slaughter, Erin Bampton, Daniel F Erin, Carla Ickert, C Allyson Jones, Carole A Estabrooks
BACKGROUND: Innovative approaches are required to facilitate the adoption and sustainability of evidence-based care practices. We propose a novel implementation strategy, a peer reminder role, which involves offering a brief formal reminder to peers during structured unit meetings. AIMS: This study aims to (a) identify healthcare aide (HCA) perceptions of a peer reminder role for HCAs, and (b) develop a conceptual framework for the role based on these perceptions...
April 27, 2017: Worldviews on Evidence-based Nursing
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