R M Smits, M J Xavier, M S Oud, G D N Astuti, A M Meijerink, P F de Vries, G S Holt, B K S Alobaidi, L E Batty, G Khazeeva, K Sablauskas, L E L M Vissers, C Gilissen, K Fleischer, D D M Braat, L Ramos, J A Veltman
STUDY QUESTION: Are there more de novo mutations (DNMs) present in the genomes of children born through medical assisted reproduction (MAR) compared to spontaneously conceived children? SUMMARY ANSWER: In this pilot study, no statistically significant difference was observed in the number of DNMs observed in the genomes of MAR children versus spontaneously conceived children. WHAT IS KNOWN ALREADY: DNMs are known to play a major role in sporadic disorders with reduced fitness such as severe developmental disorders, including intellectual disability and epilepsy...
May 30, 2022: Human Reproduction