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https://www.readbyqxmd.com/read/29663414/bidirectional-pharmacokinetic-interaction-between-amodiaquine-and-pioglitazone-in-healthy-subjects
#1
Opeyemi Edema, Babatunde A Adeagbo, Ayorinde Adehin, Tiwalade A Olugbade
Amodiaquine (AQ) and pioglitazone (PGZ) are both metabolized by CYP2C8, an enzyme also inhibited by PGZ. These drugs are likely to be administered in instances of comorbidity of malaria with type 2 diabetes. This study, hence, evaluated the possibility of a drug interaction resulting from the concurrent use of both drugs. A 3-period crossover design in 10 healthy subjects, that assessed the disposition of AQ and PGZ alone and when coadministered, was implemented with the administration of single oral doses of AQ and PGZ...
April 17, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29659851/causes-of-death-at-the-university-of-ghana-hospital-in-accra-a-37-year-review-1979-2015
#2
Edward K Sutherland, Gloria A Ansa, Frank Baiden, Enoch N B Quaye, Afua A Amoabeng, Christian Amenuveve
Background: An analysis of the causes of death in developing countries is needed to improve healthcare delivery. The aim of this study was to conduct a descriptive analysis of the causes of death at the University of Ghana Hospital from 1979 to 2015. Methods: Data were extracted from the electronic database of the University of Ghana Hospital. Diseases were grouped into three broad groups of causes of death as per the Global Burden of Disease cause list, with some diseases of epidemiological importance outlined and analysed by age, gender and time in years...
April 5, 2018: International Health
https://www.readbyqxmd.com/read/29617393/cost-and-economic-burden-of-illness-over-15-years-in-nepal-a-comparative-analysis
#3
Khin Thet Swe, Md Mizanur Rahman, Md Shafiur Rahman, Eiko Saito, Sarah K Abe, Stuart Gilmour, Kenji Shibuya
BACKGROUND: With an increasing burden of non-communicable disease in Nepal and limited progress towards universal health coverage, country- and disease-specific estimates of financial hardship related to healthcare costs need to be evaluated to protect the population effectively from healthcare-related financial burden. OBJECTIVES: To estimate the cost and economic burden of illness and to assess the inequality in the financial burden due to catastrophic health expenditure from 1995 to 2010 in Nepal...
2018: PloS One
https://www.readbyqxmd.com/read/29609858/undetectable-high-density-lipoprotein-cholesterol-in-acute-malaria
#4
Ana Rakovac Tisdall, Vivion Edward Francis Crowley, Martin Andrew Crook
We report the case of a 39-year-old West African man in whom high-density lipoprotein cholesterol (HDL-C) was identified as undetectable at <0.08 mmol/L. Total cholesterol in the same sample was 2.85 mmol/L; triglycerides were only mildly elevated at 2.32 mmol/L. He was admitted with a 2-week history of polydipsia, polyuria, weight loss and hyperpyrexia. Dual malarial infection with Plasmodium ovale and falciparum was identified and attributed to a recent trip to Nigeria without chemoprophylaxis. Also, he was diagnosed with diabetes mellitus with random hyperglycemia of 39 mmol/L but no ketonemia...
March 9, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29570720/the-double-burden-of-disease-and-the-challenge-of-health-access-evidence-from-access-bottlenecks-cost-and-equity-facility-survey-in-ghana
#5
Mawuli Komla Kushitor, Sandra Boatemaa
Despite the double burden of infectious and chronic non-communicable diseases in Africa, health care expenditure disproportionately favours infectious diseases. In this paper, we examine quantitatively the extent of this disproportionate access to diagnoses and treatment of diabetes, hypertension and malaria in Ghana. A total of 220 health facilities was surveyed across the country in 2011. Findings indicate that diagnoses and treatment of infectious diseases were more accessible than NCDs. In terms of treatment, 78% and 87% of health facilities had two of the recommended malaria drugs while less than 35% had essential diabetes and hypertension drugs...
2018: PloS One
https://www.readbyqxmd.com/read/29566721/barriers-for-conducting-clinical-trials-in-developing-countries-a-systematic-review
#6
REVIEW
Chalachew Alemayehu, Geoffrey Mitchell, Jane Nikles
BACKGROUND: Clinical trials for identification of efficient and effective new diagnostic and treatment modalities are needed to address disproportionately high burden of communicable (e.g., HIV/AIDS, tuberculosis, and malaria) and non-communicable diseases (e.g., diabetes) in developing countries. However, gross under-representation in global clinical trial platforms contributes to sustained health inequity in these countries. We reviewed the literature on barriers facing clinical researchers in developing countries for conducting clinical trials in their countries...
March 22, 2018: International Journal for Equity in Health
https://www.readbyqxmd.com/read/29423188/availability-of-brands-of-six-essential-medicines-in-124-pharmacies-in-maharashtra
#7
Colin Millard, Abhay B Kadam, Rushikesh Mahajan, Allyson M Pollock, Petra Brhlikova
Background: The aim of this study is to assess the availability and rational use of six essential medicines in private retail outlets in Maharashtra state. The study focuses on the range of brands for each medicine, and the availability of these brands in the pharmacies. The medicines were chosen because they are included in the World Health Organization's (WHO) essential medicines list (EML), the Indian national and Maharashtra state medicines list, and are all included in existing Indian public health initiatives and national disease control programmes...
June 2018: Journal of Global Health
https://www.readbyqxmd.com/read/29306246/hyperbolic-relation-between-beta-cell-function-and-insulin-sensitivity-for-type-2-diabetes-mellitus-malaria-influenza-helicobacter-pylori-chlamydia-pneumoniae-and-hepatitis-c-virus-infection-induced-inflammation-oxidative-stress-and-temporary-insulin-resistance
#8
Jean Bosco Kasiam Lasi On'kin, Benjamin Longo-Mbenza, Venant Tchokonte-Nana, Augustin Nge Okwe, Nelly Kangola Kabangu
Background/aim: We calculated the homeostatic model assessment (HOMA) for estimating insulin sensitivity and beta-cell function in normal, healthy nondiabetics with infections (malaria, influenza, HIV, Helicobacter pylori, Chlamydia pneumoniae, and hepatitis C virus), type 2 diabetic black patients, and healthy controls from Kinshasa, DR Congo. Materials and methods: A case-control study was carried out between 2006 and 2007 for black Central African participants managed for HOMA.Results: In total, 219 patients and 110 healthy controls were matched for sex and age...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29297407/pregnancy-and-the-global-disease-burden
#9
Barbara J Sina
Pregnant women experience unique physiological changes pertinent to the effective prevention and treatment of common diseases that affect their health and the health of their developing fetuses. In this paper, the impact of major communicable (HIV/AIDS, tuberculosis, malaria, helminth infections, emerging epidemic viral infections) as well as non-communicable conditions (mental illness, substance abuse, gestational diabetes, eclampsia) on pregnancy is discussed. The current state of research involving pregnant women in these areas is also described, highlighting important knowledge gaps for the management of key illnesses that impact pregnancy globally...
December 14, 2017: Reproductive Health
https://www.readbyqxmd.com/read/29283063/antiplatelet-potential-of-plant-derived-glycosides-as-possible-lead-compounds
#10
Haroon Khan, Aini Pervaiz, Mohammad A Kamal, Seema Patel
Blood platelets are crucial for maintaining hemostasis and several events in the wound-healing. However, platelet up-regulation leads to the development and the complications of several cardiovascular diseases. For the effective management of these complications, several synthetic drugs are in clinical practice such as aspirin and warfarin. since a long time. But some adverse reactions like aspirin resistance and bleed disorders cause patient in compliance and reduce their therapeutic potential. Thus, the search for potent and safer antiplatelet agents is of great interest...
December 27, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/29207467/review-of-ethnomedicinal-uses-phytochemistry-and-pharmacological-properties-of-euclea-natalensis-a-dc
#11
REVIEW
Alfred Maroyi
Euclea natalensis is traditionally used as herbal medicine for several human diseases and ailments in tropical Africa. This study reviews information on ethnomedicinal uses, botany, phytochemical constituents, pharmacology and toxicity of E. natalensis . Results of this study are based on literature search from several sources including electronic databases, books, book chapters, websites, theses and conference proceedings. This study showed that E. natalensis is used as traditional medicine in 57.1% of the countries where it is indigenous...
December 2, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29201095/toxicity-assessment-of-asteraceae-centaurea-repens-l-extract-in-mice
#12
Mohammad Moradi, Faraz Mojab, Sepideh Arbabi Bidgoli
The species Asteraceae Centaurea repens (Asteraceae), known as Acroptilon repens, and Talkhe in persian is used in folk medicine as an emetic, anti-epileptic, and anti-malaria herb in many parts of the world but its toxic effects have not determined yet. This study aimed to evaluate the acute and subchronic toxicity of this extract to find its possible adverse health effects through clinical, hematological, biochemical, and histopathological endpoints in both gender of mice. Aerial parts of the plant were air-dried and the terpene extract of aerial parts of plant was provided by percolation using methanol, petroleum ether, and diethyl ether...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29197403/setting-priorities-for-knowledge-translation-of-cochrane-reviews-for-health-equity-evidence-for-equity
#13
Peter Tugwell, Jennifer Petkovic, Vivian Welch, Jennifer Vincent, Zulfiqar A Bhutta, Rachel Churchill, Don deSavigny, Lawrence Mbuagbaw, Tomas Pantoja
BACKGROUND: A focus on equity in health can be seen in many global development goals and reports, research and international declarations. With the development of a relevant framework and methods, the Campbell and Cochrane Equity Methods Group has encouraged the application of an 'equity lens' to systematic reviews, and many organizations publish reviews intended to address health equity. The purpose of the Evidence for Equity (E4E) project was to conduct a priority-setting exercise and apply an equity lens by developing a knowledge translation product comprising summaries of systematic reviews from the Cochrane Library...
December 2, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/29185711/discovery-and-biological-evaluation-of-potent-and-selective-n-methylene-saccharin-derived-inhibitors-for-rhomboid-intramembrane-proteases
#14
Parul Goel, Thorsten Jumpertz, David C Mikles, Anežka Tichá, Minh T N Nguyen, Steven Verhelst, Martin Hubalek, Darren C Johnson, Daniel A Bachovchin, Isabella Ogorek, Claus U Pietrzik, Kvido Strisovsky, Boris Schmidt, Sascha Weggen
Rhomboids are intramembrane serine proteases and belong to the group of structurally and biochemically most comprehensively characterized membrane proteins. They are highly conserved and ubiquitously distributed in all kingdoms of life and function in a wide range of biological processes, including epidermal growth factor signaling, mitochondrial dynamics, and apoptosis. Importantly, rhomboids have been associated with multiple diseases, including Parkinson's disease, type 2 diabetes, and malaria. However, despite a thorough understanding of many structural and functional aspects of rhomboids, potent and selective inhibitors of these intramembrane proteases are still not available...
December 26, 2017: Biochemistry
https://www.readbyqxmd.com/read/29171589/comment-on-sanjay-kalra-et-al-j-pak-med-assoc-2017-5-810-813-diabetes-mellitus-malaria-and-hba1c-levels
#15
Jan Broz, Lucie Hoskovcova, Ludmila Brunerova
No abstract text is available yet for this article.
November 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/29143647/modelling-stillbirth-mortality-reduction-with-the-lives-saved-tool
#16
Hannah Blencowe, Victoria B Chou, Joy E Lawn, Zulfiqar A Bhutta
BACKGROUND: The worldwide burden of stillbirths is large, with an estimated 2.6 million babies stillborn in 2015 including 1.3 million dying during labour. The Every Newborn Action Plan set a stillbirth target of ≤12 per 1000 in all countries by 2030. Planning tools will be essential as countries set policy and plan investment to scale up interventions to meet this target. This paper summarises the approach taken for modelling the impact of scaling-up health interventions on stillbirths in the Lives Saved tool (LiST), and potential future refinements...
November 7, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29143639/linking-household-surveys-and-health-facility-assessments-to-estimate-intervention-coverage-for-the-lives-saved-tool-list
#17
Mufaro Kanyangarara, Victoria B Chou
BACKGROUND: Calls have been made for improved measurement of coverage for maternal, newborn and child health interventions. Recently, methods linking household and health facility surveys have been used to improve estimation of intervention coverage. However, linking methods rely the availability of household and health facility surveys which are temporally matched. Because nationally representative health facility assessments are not yet routinely conducted in many low and middle income countries, estimates of intervention coverage based on linking methods can be produced for only a subset of countries...
November 7, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29103923/artemether-does-not-turn-%C3%AE-cells-into-%C3%AE-cells
#18
Talitha van der Meulen, Sharon Lee, Els Noordeloos, Cynthia J Donaldson, Michael W Adams, Glyn M Noguchi, Alex M Mawla, Mark O Huising
Pancreatic α cells retain considerable plasticity and can, under the right circumstances, transdifferentiate into functionally mature β cells. In search of a targetable mechanistic basis, a recent paper suggested that the widely used anti-malaria drug artemether suppresses the α cell transcription factor Arx to promote transdifferentiation into β cells. However, key initial experiments in this paper were carried out in islet cell lines, and most subsequent validation experiments implied transdifferentiation without direct demonstration of α to β cell conversion...
January 9, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29089893/artemisinin-a-panacea-eligible-for-unrestrictive-use
#19
Dong-Sheng Yuan, Yan-Ping Chen, Li-Li Tan, Shui-Qing Huang, Chang-Qing Li, Qi Wang, Qing-Ping Zeng
Although artemisinin has been used as anti-malarial drug, accumulating evidence on the extended therapeutic potential of artemisinin emerges. Apart from anti-malaria and anti-tumor, artemisinin can also exert beneficial effects on some metabolic disorders, such as obesity, diabetes, and aging-related diseases. However, whether artemisinin should be applied to treatment of the wide-spectrum diseases is debating. Here, we discuss the predisposition of a raised risk of malarial resistance to artemisinin from consideration of the multi-target and non-specific features of artemisinin...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29076426/swertia-chirata-a-comprehensive-review-with-recent-advances
#20
Nupur Jauhari, Navneeta Bharadvaja, Neelam Sharma
BACKGROUND: Swertia chirata, an ethnomedicinal plant, is renowned for its diverse medicinal properties. The plant produces large number of therapeutic phytochemicals responsible for remedial effect against various ailments mainly chronic fever, malaria, bronchial asthma, liver disorders, certain type of mental disorder, blood purification and diabetes. Recently reported anticancer effect of S. chirata has amplified its importance in the scientific community. OBJECTIVE: The aim of this review is to deliver the pharmaceutical importance of S...
2017: Current Pharmaceutical Biotechnology
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