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https://www.readbyqxmd.com/read/29781847/identification-of-the-critical-nontechnical-skills-for-surgeons-needed-for-high-performance-in-a-variable-resource-context-notss-vrc
#1
John W Scott, Yihan Lin, Georges Ntakiyiruta, Zeta Mutabazi, William A Davis, Megan A Morris, Douglas S Smink, Robert Riviello, Steven Yule
OBJECTIVE: To identify the critical nontechnical skills (NTS) required for high performance in variable-resource contexts (VRC). BACKGROUND: As surgical training and capacity increase in low- and middle-income countries (LMICs), new strategies for improving surgical education and care in these settings are required. NTS are critical for high performance in surgery around the world. However, the essential NTS used by surgeons operating in LMICs to overcome the challenges specific to their contexts have never been described...
May 17, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29780435/photoelectrocatalytic-synthesis-of-hydrogen-peroxide-by-molecular-copper-porphyrin-supported-on-titanium-dioxide-nanotubes
#2
Dogukan H Apaydin, Hathaichanok Seelajaroen, Orathip Pengsakul, Patchanita Thamyongkit, Niyazi Serdar Sariciftci, Julia Kunze-Liebhäuser, Engelbert Portenkirchner
We report on a self-assembled system comprising a molecular copper-porphyrin photoelectrocatalyst, 5-(4-carboxy-phenyl)-10,15,20-triphenylporphyrinatocopper(II) (CuTPP-COOH), covalently bound to self-organized, anodic titania nanotube arrays (TiO2 NTs) for photoelectrochemical reduction of oxygen. Visible light irradiation of the porphyrin-covered TiO2 NTs under cathodic polarization up to -0.3 V vs. Normal hydrogen electrode (NHE) photocatalytically produces H2 O2 in pH neutral electrolyte, at room temperature and without need of sacrificial electron donors...
April 24, 2018: ChemCatChem
https://www.readbyqxmd.com/read/29769639/a-novel-cell-penetrating-peptide-protects-against-neuron-apoptosis-after-cerebral-ischemia-by-inhibiting-the-nuclear-translocation-of-annexin-a1
#3
Xing Li, Lu Zheng, Qian Xia, Lu Liu, Meng Mao, Huijuan Zhou, Yin Zhao, Jing Shi
Nuclear translocation of annexin A1 (ANXA1) has recently been reported to participate in neuronal apoptosis after cerebral ischemia. Prevention of the nuclear translocation of ANXA1 should therefore inhibit neuronal apoptosis and protect against cerebral stroke. Here, we found that, in the repeat III domain of ANXA1, the amino-acid residues from R228 to F237 function as a unique nuclear translocation signal (NTS) and are required for nuclear translocation of ANXA1. Intriguingly, we synthesized a cell-penetrating peptide derived by conjugating the trans-activator of transcription (Tat) domain to the NTS sequence...
May 16, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29762710/base-flipping-dynamics-from-an-intrahelical-to-an-extrahelical-state-exerted-by-thymine-dna-glycosylase-during-dna-repair-process
#4
Lin-Tai Da, Jin Yu
Thymine DNA glycosylase (TDG) is a DNA repair enzyme that excises a variety of mismatched or damaged nucleotides (nts), e.g. dU, dT, 5fC and 5caC. TDG is shown to play essential roles in maintaining genome integrity and correctly programming epigenetic modifications through DNA demethylation. After locating the lesions, TDG employs a base-flipping strategy to recognize the damaged nucleobases, whereby the interrogated nt is extruded from the DNA helical stack and binds into the TDG active site. The dynamic mechanism of the base-flipping process at an atomistic resolution, however, remains elusive...
May 14, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29761230/ghrelin-receptor-signaling-targets-segregated-clusters-of-neurons-within-the-nucleus-of-the-solitary-tract
#5
María Paula Cornejo, Pablo Nicolás De Francesco, Guadalupe García Romero, Enrique L Portiansky, Jeffrey M Zigman, Mirta Reynaldo, Mario Perello
Ghrelin is a stomach-derived hormone that regulates a variety of biological functions such as food intake, gastrointestinal function and blood glucose metabolism, among others. Ghrelin acts via the growth hormone secretagogue receptor (GHSR), a G-protein-coupled receptor located in key brain areas that mediate specific actions of the hormone. GHSR is highly expressed in the nucleus of the solitary tract (NTS), which is located in the medulla oblongata and controls essential functions, including orofacial, autonomic, neuroendocrine and behavioral responses...
May 14, 2018: Brain Structure & Function
https://www.readbyqxmd.com/read/29760131/identification-and-characterization-of-salmonella-enterica-serotype-newport-isolates-with-decreased-susceptibility-to-ciprofloxacin-in-the-united-states
#6
D Campbell, K Tagg, A Bicknese, A McCullough, J Chen, B E Karp, J P Folster
Nontyphoidal Salmonella (NTS) causes an estimated 1.2 million illnesses, 23,000 hospitalizations, and 450 deaths each year in the United States. Decreased susceptibility to ciprofloxacin (DSC) has historically been associated with chromosomal mutations (QRDR), but plasmid-mediated quinolone resistance (PMQR) genes are increasing. To investigate DSC among serotype Newport, we examined 40 isolates with DSC from 1996-2016. Thirty isolates (71%) contained the PMQR gene, qnrB , and eight isolates (19%) contained a QRDR...
May 14, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29748506/dietary-neurotransmitters-a-narrative-review-on-current-knowledge
#7
REVIEW
Matteo Briguglio, Bernardo Dell'Osso, Giancarlo Panzica, Antonio Malgaroli, Giuseppe Banfi, Carlotta Zanaboni Dina, Roberta Galentino, Mauro Porta
Foods are natural sources of substances that may exert crucial effects on the nervous system in humans. Some of these substances are the neurotransmitters (NTs) acetylcholine (ACh), the modified amino acids glutamate and γ-aminobutyric acid (GABA), and the biogenic amines dopamine, serotonin (5-HT), and histamine. In neuropsychiatry, progressive integration of dietary approaches in clinical routine made it necessary to discern the more about some of these dietary NTs. Relevant books and literature from PubMed and Scopus databases were searched for data on food sources of Ach, glutamate, GABA, dopamine, 5-HT, and histamine...
May 10, 2018: Nutrients
https://www.readbyqxmd.com/read/29742633/nonsurgical-admissions-with-traumatic-injury-medical-patients-are-trauma-patients-too
#8
Laura Nelson, Sally Kuzniewski, Michael Grossman, Jay A Yelon, Lisa Szydziak
Nontrauma service (NTS) admissions are an increasing problem as ground-level falls in elderly patients become more common. The admission and evaluation of trauma patients to nontrauma services in trauma centers seeking American College of Surgeons (ACS) verification, must follow the ACS mandates for performance improvement requiring some method of evaluating this population when admitted to services other than trauma, orthopedics, and neurosurgery. The purpose of this study and performance improvement project was to improve our process for the definition and evaluation of trauma patients who were being admitted to nontrauma services...
May 2018: Journal of Trauma Nursing: the Official Journal of the Society of Trauma Nurses
https://www.readbyqxmd.com/read/29741090/forming-a-highly-active-homogeneously-alloyed-aupt-co-catalyst-decoration-on-tio2-nanotubes-directly-during-anodic-growth
#9
Haidong Bian, Nhat Truong Nguyen, Jeongeun Yoo, Seyedsina Hejazi, Shiva Mohajernia, Julian Müller, Erdmann Spiecker, Hiroaki Tsuchiya, Ondrej Tomanec, Beatriz E Sanabria-Arenas, Radek Zbořil, Yang Yang Li, Patrik Schmuki
Au and Pt do not form homogeneous bulk alloys as they are thermodynamically not miscible. However, we show that anodic TiO2 nanotubes (NTs) can in-situ be uniformly decorated with homogeneous AuPt alloy nanoparticles (NPs) during their anodic growth. For this, a metallic Ti substrate containing low amounts of dissolved Au (0.1 at%) and Pt (0.1 at%) is used for anodizing. The matrix metal (Ti) is converted to oxide while at the oxide/metal interface direct noble metal particle formation and alloying of Au and Pt takes place; continuously these particles are then picked up by the growing nanotube wall...
May 9, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29735688/cisplatin-dna-adduct-repair-of-transcribed-genes-is-controlled-by-two-circadian-programs-in-mouse-tissues
#10
Yanyan Yang, Ogun Adebali, Gang Wu, Christopher P Selby, Yi-Ying Chiou, Naim Rashid, Jinchuan Hu, John B Hogenesch, Aziz Sancar
Cisplatin is a major cancer chemotherapeutic drug. It kills cancer cells by damaging their DNA, mainly in the form of Pt-d(GpG) diadducts. However, it also has serious side effects, including nephrotoxicity and hepatotoxicity that limit its usefulness. Chronotherapy is taking circadian time into account during therapy to improve the therapeutic index, by improving efficacy and/or limiting toxicity. To this end, we tested the impact of clock time on excision repair of cisplatin-induced DNA damage at single-nucleotide resolution across the genome in mouse kidney and liver...
May 7, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29733492/cognitive-training-for-technical-and-non-technical-skills-in-robotic-surgery-a-randomised-controlled-trial
#11
N Raison, K Ahmed, T Abe, O Brunckhorst, G Novara, N Buffi, C McIlhenny, H Van der Poel, M Van Hemelrijck, A Gavazzi, P Dasgupta
OBJECTIVES: To investigate the effectiveness of motor imagery (MI) for technical and non-technical skills (NTS) training in minimally invasive surgery. MATERIALS AND METHODS: A single blind, parallel group randomised controlled trial was conducted at the Vattikuti Institute of Robotic Surgery, King's College London. Novice surgeons were recruited by open invitation in 2015. Following basic robotic skills training, participants underwent simple randomisation to either MI training or standard training...
May 7, 2018: BJU International
https://www.readbyqxmd.com/read/29729998/pathogens-transmitted-in-animal-feces-in-low-and-middle-income-countries
#12
REVIEW
Miranda J Delahoy, Breanna Wodnik, Lydia McAliley, Gauthami Penakalapati, Jenna Swarthout, Matthew C Freeman, Karen Levy
Animals found in close proximity to humans in low-and middle-income countries (LMICs) harbor many pathogens capable of infecting humans, transmissible via their feces. Contact with animal feces poses a currently unquantified-though likely substantial-risk to human health. In LMIC settings, human exposure to animal feces may explain some of the limited success of recent water, sanitation, and hygiene interventions that have focused on limiting exposure to human excreta, with less attention to containing animal feces...
March 15, 2018: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29721504/multicomponent-exercise-improves-physical-functioning-but-not-cognition-and-hemodynamic-parameters-in-elderly-osteoarthritis-patients-regardless-of-hypertension
#13
Hélio José Coelho-Júnior, Ivan de Oliveira Gonçalvez, Iris Callado Sanches, Leandro Gonçalves, Erico Chagas Caperuto, Marco Carlos Uchida, Bruno Rodrigues
The present study aimed to investigate the impact of a 6-month multicomponent exercise program (MCEP) on physical function, cognition, and hemodynamic parameters of elderly normotensive (NTS) and hypertensive (HTS) osteoarthritis patients. A total of 99 elderly osteoarthritis patients (44 NTS and 55 HTS) were recruited and submitted to functional, cognitive, and hemodynamic evaluations before and after six months of a MCEP. The program of exercise was performed twice a week at moderate intensity. The physical exercises aggregated functional and walking exercises...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29717936/different-effects-of-global-osteopontin-and-macrophage-osteopontin-in-glomerular-injury
#14
Jessica Trostel, Luan D Truong, Carlos A Roncal-Jimenez, Makoto Miyazaki, Shinobu Miyazaki-Anzai, Masanari Kuwabara, Rachel H McMahan, Ana Andres-Hernando, Yuka Sato, Thomas Jensen, Miguel A Lanaspa, Richard J Johnson, Gabriela E Garcia
Osteopontin (OPN) is a pro-and ant-inflammatory molecule that simultaneously attenuates oxidative stress. Both inflammation and oxidative stress play a role in the pathogenesis of glomerulonephritis and in the progression of kidney injury. Importantly, OPN is highly induced in nephritic kidney. To further characterize the role of OPN in kidney injury we used OPN-/- mice in anti-glomerular basement membrane reactive serum-induced immune nephritis (NTS), an inflammatory and progressive model of kidney disease...
May 2, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29703142/identification-of-new-loci-involved-in-the-host-susceptibility-to-salmonella-typhimurium-in-collaborative-cross-mice
#15
Jing Zhang, Danielle Malo, Richard Mott, Jean-Jacques Panthier, Xavier Montagutelli, Jean Jaubert
BACKGROUND: Salmonella is a Gram-negative bacterium causing a wide range of clinical syndromes ranging from typhoid fever to diarrheic disease. Non-typhoidal Salmonella (NTS) serovars infect humans and animals, causing important health burden in the world. Susceptibility to salmonellosis varies between individuals under the control of host genes, as demonstrated by the identification of over 20 genetic loci in various mouse crosses. We have investigated the host response to S. Typhimurium infection in 35 Collaborative Cross (CC) strains, a genetic population which involves wild-derived strains that had not been previously assessed...
April 27, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29701734/hierarchical-tin-nanoparticles-assembled-nanopillars-for-flexible-supercapacitors-with-high-volumetric-capacitance
#16
Ping Qin, Xingxing Li, Biao Gao, Jijiang Fu, Lu Xia, Xuming Zhang, Kaifu Huo, Wenli Shen, Paul K Chu
Titanium nitride (TiN) is an attractive electrode material in fast charging/discharging supercapacitors because of its excellent conductivity. However, the low capacitance and mechanical brittleness of TiN restricts its further application in flexible supercapacitors with high energy density. Thus, it is still a challenge to rationally design TiN electrodes with both high electrochemical and mechanical properties. Herein, the hierarchical TiN nanoparticles-assembled nanopillars (H-TiN NPs) array as binder free electrodes were obtained by nitriding of hierarchical titanium dioxide (TiO2) nanopillars, which was produced by a simple hydrothermal treatment of anodic TiO2 nanotubes (NTs) array in water...
April 27, 2018: Nanoscale
https://www.readbyqxmd.com/read/29693374/a-stretchable-and-photocatalytically-renewable-electrochemical-sensor-based-on-sandwich-nanonetworks-for-real-time-monitoring-of-cells
#17
Ya-Wen Wang, Yan-Ling Liu, Jiaquan Xu, Yu Qin, Wei-Hua Huang
Stretchable electrochemical (EC) sensors have broad prospects in real-time monitoring of living cells and tissues owing to their excellent elasticity and deformability. However, the redox reaction products and cell secretions are easily adsorbed on the elec-trode, resulting in sensor fouling and passivation. Herein, we developed a stretchable and photocatalytically renewable EC sensor based on Au nanotubes (NTs) and TiO2 nanowires (NWs) sandwich nanonetworks. The external Au NTs are used for EC sensing, and internal TiO2 NWs provide photocatalytic performance to degrade contaminants, which endows the sensor with excellent EC performance, high photocatalytic activity and favorable mechanical tensile property...
April 25, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29692933/murine-nephrotoxic-nephritis-as-a-model-of-chronic-kidney-disease
#18
M K E Ougaard, P H Kvist, H E Jensen, C Hess, I Rune, H Søndergaard
Using the nonaccelerated murine nephrotoxic nephritis (NTN) as a model of chronic kidney disease (CKD) could provide an easily inducible model that enables a rapid test of treatments. Originally, the NTN model was developed as an acute model of glomerulonephritis, but in this study we evaluate the model as a CKD model and compare CD1 and C57BL/6 female and male mice. CD1 mice have previously showed an increased susceptibility to CKD in other CKD models. NTN was induced by injecting nephrotoxic serum (NTS) and evaluated by CKD parameters including albuminuria, glomerular filtration rate (GFR), mesangial expansion, and renal fibrosis...
2018: International Journal of Nephrology
https://www.readbyqxmd.com/read/29690553/pirna-profiling-of-dengue-virus-type-2-infected-asian-tiger-mosquito-and-midgut-tissues
#19
Yanhai Wang, Binbin Jin, Peiwen Liu, Jing Li, Xiaoguang Chen, Jinbao Gu
The Asian tiger mosquito, Aedes albopictus , is a competent vector for the majority of arboviruses. The mosquito innate immune response is a primary determinant for arthropod-borne virus transmission, and the midgut is the first barrier to pathogen transmission. Mosquito antiviral immunity is primarily mediated by the small interfering RNA pathway. However, the roles that the P-element induced wimpy testis (PIWI)-interacting RNA (piRNA) pathway play in antiviral immunity in Ae. albopictus and its midgut still need further exploration...
April 22, 2018: Viruses
https://www.readbyqxmd.com/read/29682811/upregulation-of-hypothalamic-arginine-vasopressin-by-peripherally-administered-furosemide-in-transgenic-rats-expressing-arginine-vasopressin-enhanced-green-fluorescent-protein
#20
Hiromichi Ueno, Mitsuhiro Yoshimura, Kentaro Tanaka, Haruki Nishimura, Kazuaki Nishimura, Satomi Sonoda, Yasuhito Motojima, Reiko Saito, Takashi Maruyama, Tetsu Miyamoto, Ryota Serino, Masahito Tamura, Tatsushi Onaka, Yutaka Otsuji, Yoichi Ueta
Furosemide, which is used worldwide as a diuretic agent, inhibits sodium reabsorption in the Henle's loop, resulting in diuresis and natriuresis. Arginine vasopressin (AVP) is synthesized in the supraoptic nucleus (SON), paraventricular nucleus (PVN), and suprachiasmatic nucleus (SCN) of the hypothalamus. The synthesis AVP in the magnocellular neurons of SON and PVN physiologically regulated by plasma osmolality and blood volume and contributed water homeostasis by increasing water reabsorption in the collecting duct...
April 22, 2018: Journal of Neuroendocrinology
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