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Wei Wei, Zhongxue Yang, Weijie Song, Fengyun Hu, Bo Luan, Peiqiang Li, Hongzong Yin
CdSeTe nanoparticles (CdSeTe NPs)/TiO2 nanotubes (TiO2 NTs) and CdSeTe nanosheets (CdSeTe NSs)/TiO2 NTs were fabricated by photoelectric deposition method and hydrothermal method, respectively. The band gap of the CdSeTe NPs/TiO2 NTs (1.24eV) is narrower than that of the CdSeTe NSs/TiO2NTs (1.48eV). The photoelectrochemical conversion efficiency of the CdSeTe NPs/TiO2 NTs is 2.72 times larger than that of the CdSeTe NSs/TiO2 NTs, manifesting that the CdSeTe NPs/TiO2 NTs possessed more excellent photocatalytic performance...
November 16, 2016: Journal of Colloid and Interface Science
Chengcheng Li, Ang Li, Zhibin Luo, Jijie Zhang, Xiaoxia Chang, Zhiqi Huang, Tuo Wang, Jinlong Gong
Nanotubular Fe2 O3 is a promising photoanode material, and producing morphologies that withstand high-temperature calcination (HTC) is urgently needed to enhance the photoelectrochemical (PEC) performance. This work describes the design and fabrication of Fe2 O3 nanotube arrays that survive HTC for the first time. By introducing a ZrO2 shell on hydrothermal FeOOH nanorods by atomic layer deposition, subsequent high-temperature solid-state reaction converts FeOOH-ZrO2 nanorods to ZrO2 -induced Fe2 O3 nanotubes (Zr-Fe2 O3 NTs)...
February 21, 2017: Angewandte Chemie
Bhawana Pandey, Madhavan Jaccob, Gopalan Rajaraman
Comparative oxidative abilities of nonheme Fe(IV)[double bond, length as m-dash]NTs and Fe(IV)[double bond, length as m-dash]O species using DFT has been explored. Our calculations reveal that the Fe(IV)[double bond, length as m-dash]NTs is found to be a stronger oxidant in two electron transfer reactions and react exclusively via π channels while the Fe(IV)[double bond, length as m-dash]O species is found to be a stronger oxidant when the σ-pathway is activated such as in HAT reactions.
February 21, 2017: Chemical Communications: Chem Comm
Armando J Espadas-Alvarez, Michael J Bannon, Carlos E Orozco-Barrios, Lourdes Escobedo-Sanchez, Jose Ayala-Davila, David Reyes-Corona, Guadalupe Soto-Rodriguez, Vicente Escamilla-Rivera, Andrea De Vizcaya-Ruiz, M Eugenia Gutierrez-Castillo, America Padilla-Viveros, Daniel Martinez-Fong
The human glial-cell derived neurotrophic factor (hGDNF) gene transfer by neurotensin (NTS)-polyplex nanoparticles functionally restores the dopamine nigrostriatal system in experimental Parkinson's disease models. However, high levels of sustained expression of GDNF eventually can cause harmful effects. Herein, we report an improved NTS-polyplex nanoparticle system that enables regulation of hGDNF expression within dopaminergic neurons. We constructed NTS-polyplex nanoparticles containing a single bifunctional plasmid that codes for the reverse tetracycline-controlled transactivator advanced (rtTA-Adv) under the control of NBRE3x promoter, and for hGDNF under the control of tetracycline-response element (TRE)...
February 17, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
Mohammad Khalid Parvez
AIM: To investigate the role of non-structural open reading frame 1 "Y-domain" sequences in the hepatitis E virus (HEV) life cycle. METHODS: Sequences of human HEV Y-domain (amino acid sequences 216-442) and closely-related viruses were analyzed in silico. Site-directed mutagenesis of the Y-domain (HEV SAR55) was carried out and studied in the replicon-baculovirus-hepatoma cell model. In vitro transcribed mRNA (pSK-GFP) constructs were transfected into S10-3 cells and viral RNA replicating GFP-positive cells were scored by flow cytometry...
January 28, 2017: World Journal of Gastroenterology: WJG
L B Martins, A L Teixeira, R B Domingues
Neurotrophins (NTs) have been implicated in generation and modulation of nociceptive pathways. Change in NTs levels is associated with painful conditions and neurological diseases such as migraine. Currently, it is generally recognized that migraine headaches result from the activation and sensitization of trigeminal sensory afferent fibers leading to neuropeptides release such as calcitonin gene-related peptide (CGRP) and substance P (SP). This triggers an inflammatory cascade causing a neurogenic inflammation...
2017: Vitamins and Hormones
Xingtang Yang, Kai Jin, Fan Yang, Guoping Yuan, Wenbin Liu, Lunhui Xiang, Zhenqiang Wu, Zixiong Li, Jianying Mao, Junqing Shen, Nelson Lombe, Hemitério Zandamela, Lucrece Hazoume, Xiaomei Hou, Yibo Ding, Guangwen Cao
Nontyphoidal Salmonella (NTS) gastroenteritis is a widespread global foodborne disease. To identify the epidemiologic characteristics, sources of food contamination, and risk factors of NTS gastroenteritis, epidemiologic data and stool specimens of diarrheal patients were collected from sentinel hospitals in Baoshan, Shanghai, People's Republic of China, between 2010 and 2014. Food products from nearby farmers' markets and animal feces from live poultry markets and livestock farms were sampled to identify the pathogen; a case-control study was conducted to characterize risk factors of NTS gastroenteritis...
February 16, 2017: Journal of Food Protection
Linda Aurelia Andoh, Shabana Ahmed, John Elmerdahl Olsen, Kwasi Obiri-Danso, Mercy Jemima Newman, Japheth Awuletey Opintan, Lisa Barco, Anders Dalsgaard
BACKGROUND: Non-typhoidal Salmonella (NTS) is a public health problem worldwide and particularly in Africa with high disease burden. This study characterized Salmonella isolates from humans in Ghana to determine serovar distribution, phage types, and antimicrobial resistance. Further, the clonal relatedness among isolates was determined. METHODS: One hundred and thirty-seven Salmonella isolates (111 clinical and 26 public toilet) were characterized using standard serotyping, phage typing, and antimicrobial susceptibility testing methods...
2017: Tropical Medicine and Health
János Barna, Eva Renner, Antónia Arszovszki, Melinda Cservenák, Zsolt Kovács, Miklós Palkovits, Arpád Dobolyi
OBJECTIVES: The aim of the study was to understand the effects of suckling on the brain of the pups by mapping their brain activation pattern in response to suckling. METHODS: The c-fos method was applied to identify activated neurons. Fasted rat pups were returned to their mothers for suckling and sacrificed 2 hours later for Fos immunohistochemistry. Double labeling was also performed to characterize some of the activated neurons. For comparison, another group of fasted pups were given dry food before Fos mapping...
February 10, 2017: Nutritional Neuroscience
Na Xu, Hao Cheng, Jiangwen Xu, Feng Li, Biao Gao, Zi Li, Chenghao Gao, Kaifu Huo, Jijiang Fu, Wei Xiong
Antibiotic-resistant bacteria have become a major issue due to the long-term use and abuse of antibiotics in treatments in clinics. The combination therapy of antibiotics and silver (Ag) nanoparticles is an effective way of both enhancing the antibacterial effect and decreasing the usage of antibiotics. Although the method has been proved to be effective in vitro, no in vivo tests have been carried out at present. Herein, we described a combination therapy of local delivery of Ag and systemic antibiotics treatment in vitro in an infection model of rat...
2017: International Journal of Nanomedicine
Kristin Bornstein, Laura Hungerford, David Hartley, John D Sorkin, Milagritos D Tapia, Samba O Sow, Uma Onwuchekwa, Raphael Simon, Sharon M Tennant, Myron M Levine
BACKGROUND: In sub-Saharan Africa, systematic surveillance of young children with suspected invasive bacterial disease (e.g., septicemia, meningitis) has revealed non-typhoidal Salmonella (NTS) to be a major pathogen exhibiting high case fatality (~20%). Where infant vaccination against Haemophilus influenzae type b (Hib) and Streptococcus pneumoniae has been introduced to prevent invasive disease caused by these pathogens, as in Bamako, Mali, their burden has decreased markedly. In parallel, NTS has become the predominant invasive bacterial pathogen in children aged <5 years...
February 2017: PLoS Neglected Tropical Diseases
Gerrit van Rensburg, Sebastian Mackedenski, Chow H Lee
Coding region determinant-binding protein (CRD-BP) binds to the 3'-UTR of microphthalmia-associated transcription factor (MITF) mRNA to prevent its targeted degradation by miR-340. Here, we aim to further understand the molecular interaction between CRD-BP and MITF RNA. Using point mutation in the GXXG motif of each KH domains, we showed that all four KH domains of CRD-BP are important for their physical association with MITF RNA. We mapped the CRD-BP-binding site in the 3'-UTR of MITF RNA from nts 1330-1740 and showed that the 49-nt fragment 1621-1669 is the minimal size MITF RNA for binding...
2017: PloS One
Morris Gordon, Christopher W R Fell, Helen Box, Michael Farrell, Alison Stewart
BACKGROUND: Healthcare increasingly recognises and focusses on the phenomena of 'safe practice' and 'patient safety.' Success with non-technical skills (NTS) training in other industries has led to widespread transposition to healthcare education, with communication and teamwork skills central to NTS frameworks. OBJECTIVE: This study set out to identify how the context of interprofessional simulation learning influences NTS acquisition and development of 'safety' amongst learners...
2017: Medical Education Online
Qinwei An, Xianquan Meng, Ke Xiong, Yunlei Qiu, Weihua Lin
ZnS nanotubes (NTs) were successfully prepared via a one-step thermal evaporation process without using any templates. The resulting NTs were single crystalline and structurally uniform. Based on experimental analysis, a tube-growth vapor-liquid-solid process was proposed as the growth mechanism of ZnS NTs. A metal-semiconductor-metal full-nanostructured ultraviolet (UV) photodetector with ZnS NTs as the active layer, and Ag nanowires of low resistivity and high transmissivity as electrodes, was fabricated and characterized...
March 10, 2017: Nanotechnology
Koichi Okamoto, Masakuni Amari, Toshio Fukuda, Keiji Suzuki, Masamitsu Takatama
We compared semiquantitatively AT8 immunoreactivity in the locus ceruleus (LC) and hippocampus of 154 brains from routine autopsies to investigate the initial sites of phosphorylated tau (phospho-tau) development. The numbers of AT8-positive neurons and the severity of AT8-positive neuropil threads (NTs) in the LC were strongly associated: there were no cases with AT8-positive neurons that lacked NTs and 20 cases (13%) had only NTs in the LC. Phospho-tau pathologies in the LC were almost equally on both sides, although some cases (7...
February 6, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
Ogun Adebali, Yi-Ying Chiou, Jinchuan Hu, Aziz Sancar, Christopher P Selby
We used high-throughput sequencing of short, cyclobutane pyrimidine dimer-containing ssDNA oligos generated during repair of UV-induced damage to study that process at both mechanistic and systemic levels in Escherichia coli Numerous important insights on DNA repair were obtained, bringing clarity to the respective roles of UvrD helicase and Mfd translocase in repair of UV-induced damage. Mechanistically, experiments showed that the predominant role of UvrD in vivo is to unwind the excised 13-mer from dsDNA and that mutation of uvrD results in remarkable protection of that oligo from exonuclease activity as it remains hybridized to the dsDNA...
February 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
Antonio López-Piñeiro, David Peña, Ángel Albarrán, Javier Sánchez-Llerena, José Manuel Rato-Nunes, María Ángeles Rozas
BACKGROUND: Bentazon is a widely used herbicide in rice agroecosystems that has commonly been found in water resources. To assess how tillage and water regimes impact the sorption-desorption, dissipation, and leaching of bentazon in Mediterranean rice growing conditions, field experiments were carried out using tillage and flooding (TF), tillage and sprinkler irrigation (TS), no-tillage and sprinkler irrigation (NTS), and long-term no-tillage and sprinkler irrigation (NTS7). RESULTS: After three years, the Kd values in TS were 2...
February 3, 2017: Pest Management Science
Yu Sasano, Takahiro Kariya, Shogo Usugi, Minetaka Sugiyama, Satoshi Harashima
As yeast is commonly used for RNA production, it is industrially important to breed strains with high RNA contents. The upstream activating factor (UAF) plays an important role in transcription of ribosomal RNA (rRNA), a major constituent of intracellular RNA species. Here, we targeted the essential rRNA transcription regulator Rrn5 of Saccharomyces cerevisiae, a component of the UAF complex, and disrupted the genomic RRN5 gene using a helper plasmid carrying an RRN5 gene. Then we isolated nine suppressor mutants (Sup mutants) of RRN5 gene disruption, causing deficiency in rRNA transcription...
December 2017: AMB Express
Majlinda Kullolli, Dan A Rock, Ji Ma
Characterization of in vitro and in vivo catabolism of therapeutic proteins has increasingly become an integral part of discovery and development process for novel proteins. Unambiguous and efficient identification of catabolites can not only facilitate accurate understanding of pharmacokinetic profiles of drug candidates, but also enables follow up protein engineering to generate more catabolically stable molecules with improved properties (pharmacokinetics and pharmacodynamics). Immunoaffinity capture (IC) followed by top-down intact protein analysis using either matrix-assisted laser desorption/ionization or electrospray ionization mass spectrometry analysis have been the primary methods of choice for catabolite identification...
February 3, 2017: Journal of Proteome Research
Xi Yang, Hongfeng Li, Huahui Sun, Hongxia Fan, Yaqi Hu, Min Liu, Xin Li, Hua Tang
: microRNAs (miRNAs) are a class of small single-stranded non-coding functional RNAs. Hepatitis B virus (HBV) is an enveloped DNA virus with virions and subviral forms of particles that lack a core. It was not known whether HBV encodes miRNAs. Here, we identified an HBV-encoded miRNA (called HBV-miR-3) by deep sequencing and northern blot. HBV-miR-3 is located at nts 373-393 of the HBV genome and was generated from 3.5Kb, 2,4Kb and 2.1Kb HBV in classic miRNA biogenesis (Drosha-Dicer dependent) manner...
February 1, 2017: Journal of Virology
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