keyword
https://read.qxmd.com/read/38191802/varpa-in-silico-additive-screening-for-protein-based-lighting-devices
#1
JOURNAL ARTICLE
Jesús Agustín Banda-Vázquez, Alexander Mauz, Juan Pablo Fuenzalida Werner, Rubén D Costa
Protein optoelectronics is an emerging field facing implementation and stabilization challenges of proteins in harsh non-natural environments, such as dry polymers, inorganic materials, etc., operating at high temperatures/irradiations. In this context, additives promoting structural and functional protein stabilization are paramount to realize highly performing devices. On one hand, trial-error experimental assays based on previous knowledge of classical additives in aqueous solutions are effort/time-consuming, while their translation to water-less matrices is uncertain...
January 8, 2024: Small Methods
https://read.qxmd.com/read/37991900/our-scientific-journey-through-the-ups-and-downs-of-blood-glucose-control-in-the-icu
#2
JOURNAL ARTICLE
Greet Van den Berghe, Ilse Vanhorebeek, Lies Langouche, Jan Gunst
This article tells the story of our long search for the answer to one question: Is stress hyperglycemia in critically ill patients adaptive or maladaptive? Our earlier work had suggested the lack of hepatic insulin effect and hyperglycemia as jointly predicting poor outcome. Therefore, we hypothesized that insulin infusion to reach normoglycemia, tight glucose control, improves outcome. In three randomized controlled trials (RCTs), we found morbidity and mortality benefit with tight glucose control. Moving from the bed to the bench, we attributed benefits to the prevention of glucose toxicity in cells taking up glucose in an insulin-independent, glucose concentration gradient-dependent manner, counteracted rather than synergized by insulin...
March 1, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/37853343/adaptive-designs-in-critical-care-trials-a-simulation-study
#3
JOURNAL ARTICLE
W Li, V Cornelius, S Finfer, B Venkatesh, L Billot
BACKGROUND: Adaptive clinical trials are growing in popularity as they are more flexible, efficient and ethical than traditional fixed designs. However, notwithstanding their increased use in assessing treatments for COVID-19, their use in critical care trials remains limited. A better understanding of the relative benefits of various adaptive designs may increase their use and interpretation. METHODS: Using two large critical care trials (ADRENAL. CLINICALTRIALS: gov number, NCT01448109...
October 18, 2023: BMC Medical Research Methodology
https://read.qxmd.com/read/36478577/meals-and-movies-making-our-microbiota-merry
#4
JOURNAL ARTICLE
Olivia Yousef, Stephen De Souza
OBJECTIVE: To investigate the impact of festive cinematic diets on the gut microbiota. DESIGN: Observational (watching films) and creative review. Sadly, we couldn't incorporate any snowball sampling. SETTING: In front of a television, by a blazing log fire. PARTICIPANTS: Everyone: you don't need to be on the nice list! MAIN OUTCOME MEASURES: Microbiota INdex of Comparative Evaluation for Pictorial Infographic Evidence (MINCE PIE) scores (difference between the numbers of microbiota-enhancing and microbiota-detrimental food groups) for foods depicted in twelve festive films...
December 12, 2022: Medical Journal of Australia
https://read.qxmd.com/read/35990336/effect-of-different-sweeteners-on-the-quality-fatty-acid-and-volatile-flavor-compounds-of-braised-pork
#5
JOURNAL ARTICLE
Zhi-Gui He, Ying Zhang, Ming-Duo Yang, Yu-Qing Zhang, Ying-Ying Cui, Mi-Ying Du, Dong Zhao, Hui Sun
This study aimed to assess how several sweeteners (white sugar, Siraitia grosvenorii fruit, mogrosides, and stevia glycoside) affected the flavor, fatty acid composition, and quality of braised pork. The findings indicated that braised meat prepared with sweeteners differed from typical braised pork. When simmered for 60 min, the typical braised pork with white granulated sugar exhibited a significant cooking loss (CL) and little water content. Significantly more than in the group containing Siraitia grosvenorii , mogroside, and stevia glycoside, the Thiobarbituric acid (TBARS) value increased by 14...
2022: Frontiers in Nutrition
https://read.qxmd.com/read/35842591/glycemic-control-in-critically-ill-patients-with-or-without-diabetes
#6
JOURNAL ARTICLE
Ka Man Fong, Shek Yin Au, George Wing Yiu Ng
BACKGROUND: Early randomized controlled trials have demonstrated the benefits of tight glucose control. Subsequent NICE-SUGAR study found that tight glucose control increased mortality. The optimal glucose target in diabetic and nondiabetic patients remains unclear. This study aimed to evaluate the relationship between blood glucose levels and outcomes in critically ill patients with or without diabetes. METHODS: This was a retrospective analysis of the eICU database...
July 16, 2022: BMC Anesthesiology
https://read.qxmd.com/read/35100936/lna-induced-dynamic-stability-in-a-therapeutic-aptamer-insights-from-molecular-dynamics-simulations
#7
JOURNAL ARTICLE
Rupak Pal, Indrajit Deb, Joanna Sarzynska, Ansuman Lahiri
Modulation of structural and thermodynamic properties of nucleic acids with synthetic modifications is a promising area of research with possible applications in nanotechnology and nanotherapeutics. Locked nucleic acid (LNA) is one such modification in which the C4' and O2' atoms of the sugar moiety are connected through a methylene bridge. The LNA modified DNA aptamer RNV66, and its unmodified counterpart V7t1, both of which target the vascular endothelial growth factor (VEGF) implicated in oncogenic angiogenesis, have a G-rich tract that can fold into G-quadruplex structures...
February 1, 2022: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/34673948/sugar-and-spike-not-so-nice
#8
EDITORIAL
Steven E McKenzie
No abstract text is available yet for this article.
October 21, 2021: Blood
https://read.qxmd.com/read/33769582/enhancing-erythrocyte-influenza-virus-specificity-by-glycan-conjugated-gold-nanoparticle-validation-of-hemagglutination-by-aptamer-and-neuraminidases
#9
JOURNAL ARTICLE
Meiyi Ye, Lei Lin, Wei Yang, Subash C B Gopinath
This study demonstrated the terminated sialo-sugar chains (Neu5Acα2,6Gal and Neu5Acα2,3Gal)-mediated specificity enhancement of influenza virus and chicken red blood cell (RBC) by hemagglutination assay. These glycan chains were immobilized on the gold nanoparticle (GNP) to withhold the higher numbers. With the preliminary optimization, a clear button formation with 0.5% RBC was visualized. On the other hand, intact B/Tokio/53/99 with 750 nM hemagglutinin (HA) displayed a nice hemagglutination. The interference on the specificity of RBC and influenza virus was observed by anti-influenza aptamer at the concentration 31 nM; however, there is no hemagglutination prevention was noticed in the presence of complementary aptamer sequences...
April 2022: Biotechnology and Applied Biochemistry
https://read.qxmd.com/read/33650454/monitoring-the-impact-of-aggressive-glycemic-intervention-during-critical-care-after-cardiac-surgery-with-a-glycemic-expert-system-for-nurse-implemented-euglycemia-the-magic-genie-project
#10
JOURNAL ARTICLE
R Harsha Rao, Peter L Perreiah, Candace A Cunningham
A novel, multi-dimensional protocol named GENIE has been in use for intensive insulin therapy (IIT, target glucose <140 mg/dL) in the surgical intensive care unit (SICU) after open heart surgery (OHS) at VA Pittsburgh since 2005. Despite concerns over increased mortality from IIT after the publication of the NICE-SUGAR Trial, it remains in use, with ongoing monitoring under the MAGIC GENIE Project showing that GENIE performance over 12 years (2005-2016) aligns with the current consensus that IIT with target blood glucose (BG) <140 mg/dL is advisable only if it does not provoke severe hypoglycemia (SH)...
March 2021: Journal of Diabetes Science and Technology
https://read.qxmd.com/read/32942615/objective-facts-or-misleading-hype-associations-between-features-of-e-cigarette-marketing-and-sales-on-a-chinese-e-commerce-platform
#11
JOURNAL ARTICLE
Yibei Chen, Shaojing Sun, Xiaoquan Zhao, Han Zhou, Fan Wang
Background : Electronic cigarettes (e-cigarettes) have been increasingly advertised and marketed in China in recent years. This study examined the practice and impact of e-cigarette online marketing on a major retail website-Tmall.com. Methods : Data were obtained by crawling 449 online pages of e-cigarette marketing. Content analysis was conducted to summarize the marketing practices for four types of e-cigarettes, and multilevel modeling (MLM) was implemented to explore factors predictive of the online sales of the products...
September 15, 2020: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/32370789/does-asymmetry-in-patient-recruitment-in-large-critical-care-trials-follow-the-pareto-principle
#12
JOURNAL ARTICLE
Mahesh Ramanan, Laurent Billot, Dorrilyn Rajbhandari, John Myburgh, Simon Finfer, Rinaldo Bellomo, Balasubramanian Venkatesh
BACKGROUND: Randomised controlled trials (RCT) may be hindered by slow recruitment rates, particularly in critically ill patients. While statistical models to predict recruitment rates have been described, no systematic assessment has been conducted of the distribution of recruitment across sites, temporal trends in site participation and impact of competing trials on patient recruitment. METHODS: We used recruitment and screening logs from the SAFE, NICE-SUGAR, RENAL, CHEST and ADRENAL trials, five of the largest critical care RCTs...
May 5, 2020: Trials
https://read.qxmd.com/read/31303713/preoperative-laboratory-testing-comparison-of-national-institute-of-clinical-excellence-guidelines-with-current-practice-an-observational-study
#13
JOURNAL ARTICLE
Neeraj Guttikonda, Anitha Nileshwar, Madhu Rao, T K Sushma
BACKGROUND AND AIMS: Preoperative laboratory testing is done to detect abnormalities in the body not detected by clinical examination. Often a battery of tests is advocated as a routine for patients scheduled for low or intermediate risk surgery. This prospective observational study was aimed to assess agreement of the current practice of preoperative laboratory investigations with the National Institute of Clinical Excellence (NICE) guidelines, and the impact of investigations on patient care and costs...
2019: Journal of Anaesthesiology, Clinical Pharmacology
https://read.qxmd.com/read/30455957/acute-glycemic-control-in-diabetics-how-sweet-is-oprimal-pro-sweeter-is-better-in-diabetes
#14
JOURNAL ARTICLE
Rinaldo Bellomo
Background: The optimal level of glycemic control in ICU patients has been the subject of intense investigation over the last 20 years. A pivotal study (the NICE-SUGAR study) involving more than 6,000 patients has established a target between 8 and 10 mmol/l (144 to 180 mg/dl) as the current standard of care. However, this study did not address whether patients with diabetes should be treated differently and, in particular, whether in such patients a higher glucose target should be used...
2018: Journal of Intensive Care
https://read.qxmd.com/read/29247919/two-sugar-rhodamine-turn-on-fluorescent-probes-for-the-selective-detection-of-fe-3
#15
JOURNAL ARTICLE
Qing Chen, Zhijie Fang
Two new sugar-rhodamine fluorescent probes (RDG1 and RDG2) have been synthesized and characterized by1 H NMR,13 C NMR and HRMS. Their UV-Vis, fluorescence spectra and fluorescence-response to Fe3+ are investigated and discussed. RDG1 had a very nice linear relationship between UV absorbance and Fe3+ concentration with the correlation coefficient as high as 0.997 and the detection limit is 3.46×10-6 M. Upon the addition of Fe3+ , the spirolactam ring of RDG1 was opened and a 1:1 metal ligand complex was formed from Job's plot...
March 15, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://read.qxmd.com/read/29210453/a-combined-approach-of-infrared-spectroscopy-and-multivariate-analysis-for-the-simultaneous-determination-of-sugars-and-fructans-in-strawberry-juices-during-storage
#16
JOURNAL ARTICLE
Lucía Cassani, Mauricio Santos, Esteban Gerbino, María Del Rosario Moreira, Andrea Gómez-Zavaglia
In this work, a Fourier transform mid-infrared spectroscopy (FTIR)-based method was developed for simultaneously quantifying simple sugars and exogenously added fructooligosaccharides (FOS) in strawberry juices preserved for up to 14 d using nonthermal techniques (geraniol and vanillin+ultrasound). The main spectral differences were observed in the 1200 to 900 cm-1 region. The presence of FOS was identified by the typical bands at 1134, 1034, and 935 cm-1 . During storage, a significant decrease of sucrose was concomitant to an increase of glucose and fructose in juices stored without any previous preservation treatment, as determined by high-performance liquid chromatography (HPLC)...
March 2018: Journal of Food Science
https://read.qxmd.com/read/28979511/glycaemic-control-in-intensive-care-everything-in-moderation
#17
JOURNAL ARTICLE
Arjun Devanesan, Jonathan Lloyd, Hanif Samad, Shibaji Saha
INTRODUCTION: Glycaemic control is an important predictor of mortality in sepsis. Various international organizations including the Surviving Sepsis campaign recommend glycaemic control in critical illness with a glucose target between 6.1-10 mmol/L. The NICE-SUGAR Trial in 2009 was a landmark in the debate over tight versus liberal glycaemic control in the critically ill and subsequent guidelines have been adjusted to reflect a move towards moderate glycaemic control. METHODS: We conducted a nation-wide study comparing glucose targets used in intensive care units in the United Kingdom in 2007 with those used in 2014 to 2015 to see the impact of the NICE-SUGAR study and subsequent guideline changes...
November 2016: Journal of the Intensive Care Society
https://read.qxmd.com/read/28637358/comparative-simulation-study-of-glucose-control-methods-designed-for-use-in-the-intensive-care-unit-setting-via-a-novel-controller-scoring-metric
#18
COMPARATIVE STUDY
Jeremy DeJournett, Leon DeJournett
BACKGROUND: Effective glucose control in the intensive care unit (ICU) setting has the potential to decrease morbidity and mortality rates and thereby decrease health care expenditures. To evaluate what constitutes effective glucose control, typically several metrics are reported, including time in range, time in mild and severe hypoglycemia, coefficient of variation, and others. To date, there is no one metric that combines all of these individual metrics to give a number indicative of overall performance...
November 2017: Journal of Diabetes Science and Technology
https://read.qxmd.com/read/28286827/doing-pre-operative-investigations-in-emergency-department-a-clinical-audit
#19
JOURNAL ARTICLE
Muhammad Salman Rafiq, Maria Rafiq, Muhammad Imran Rafiq, Seema Gul Salman, Sania Hafeez
INTRODUCTION: Pre-operative investigations for emergency surgical patients differ between centers. Following established guidelines can reduce unnecessary investigation, cost of treatment and hospital stay. The present audit was carried out to evaluate the condition of doing pre-operative investigations for three common surgical emergencies compared to National Institute for Health and Care Excellence (NICE) guidelines and local criteria. METHODS: A retrospective clinical audit of acute-appendicitis, abscess and hernia patients admitted to the emergency department was carried out over a one-year period from July 2014 to July 2015...
2017: Emergency (Tehran, Iran)
https://read.qxmd.com/read/27338907/a-survey-of-sports-drinks-consumption-among-adolescents
#20
JOURNAL ARTICLE
D Broughton, R M Fairchild, M Z Morgan
Background Sports drinks intended to improve performance and hydrate athletes taking part in endurance sport are being marketed to children, for whom these products are not intended. Popularity among children has grown exponentially. Worryingly they consume them socially, as well as during physical activity. Sports drinks are high in sugar and are acidic. Product marketing ignores the potential harmful effects of dental caries and erosion.Objective To investigate the use of sports drinks by children.Method One hundred and eighty-three self-complete questionnaires were distributed to four schools in South Wales...
June 24, 2016: British Dental Journal
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