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https://www.readbyqxmd.com/read/28642284/excitation-of-gabaergic-neurons-in-the-bed-nucleus-of-the-stria-terminalis-triggers-immediate-transition-from-non-rapid-eye-movement-sleep-to-wakefulness-in-mice
#1
Shota Kodani, Shingo Soya, Takeshi Sakurai
Emotionally salient situations usually trigger arousal along with autonomic and neuroendocrine reactions. To examine whether the extended amygdala plays a role in sleep/wakefulness regulation, we examined the effects of optogenetic and pharmacogenetic excitation of GABAergic neurons in the bed nucleus of the stria terminalis (GABA(BNST) neurons). Acute optogenetic excitation of these cells during non-rapid eye movement (NREM) sleep resulted in immediate state transition to wakefulness, while stimulation during rapid eye movement (REM) sleep showed no effect on sleep/wakefulness states in male mice...
June 22, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28627704/matrix-metalloproteinase-2-and-9-contribute-to-functional-integrity-and-noise%C3%A2-induced-damage-to-the-blood-labyrinth-barrier
#2
Jun Wu, Weiju Han, Xingrui Chen, Weiwei Guo, Ke Liu, Ruoya Wang, Jishuai Zhang, Na Sai
The cochlear blood-labyrinth barrier (BLB), located in the stria vascularis, is critical for the homeostasis of cochlear solutes and ion transport. Significant disruption to the BLB occurs early during noise‑induced hearing loss. Matrix metalloproteinase (MMP)‑2 and ‑9 are important molecules known to be capable of degrading tight junction (TJ) proteins. The TJ proteins are important components of the extracellular matrix (ECM), required to maintain BLB integrity and permeability. Previous studies have demonstrated that MMP‑2 and ‑9, rich in healthy cochlea, serve an essential role in regulating the cochlear response to acoustic trauma...
June 15, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28625549/the-long-term-effects-of-stress-and-kappa-opioid-receptor-activation-on-conditioned-place-aversion-in-male-and-female-california-mice
#3
Abigail R Laman-Maharg, Tiffany Copeland, Evelyn Ordoñes Sanchez, Katharine L Campi, Brian C Trainor
Psychosocial stress leads to the activation of kappa opioid receptors (KORs), which induce dysphoria and facilitate depression-like behaviors. However, less is known about the long-term effects of stress and KORs in females. We examined the long-term effects of social defeat stress on the aversive properties of KOR activation in male and female California mice (Peromyscus californicus) using a conditioned place aversion paradigm. Female California mice naïve to social defeat, formed a place aversion following treatment with 2...
June 15, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28614607/anatomical-and-functional-implications-of-crh-neurons-in-a-septal-nucleus-of-the-avian-brain-an-emphasis-on-glial-neuronal-interaction-via-v1a-receptors-in-vitro
#4
Gurueswar Nagarajan, Alexander Jurkevich, Seong W Kang, Wayne J Kuenzel
Previously, we showed that corticotropin releasing hormone immunoreactive (CRH-ir) neurons in a septal structure are associated with stress and the hypothalamo-pituitary-adrenal axis in birds. In this study, we focused upon CRH-ir neurons located within the septal structure called the nucleus of the hippocampal commissure (NHpC). Immunocytochemical and gene expression analyses were used to identify the anatomical and functional characteristics of cells within the NHpC. A comparative morphometry analysis showed that CRH-ir neurons in the NHpC were significantly larger than CRH-ir parvocellular neurons in the paraventricular nucleus of the hypothalamus (PVN) and lateral bed nucleus of the stria terminalis...
June 14, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28612996/crf1-and-crf2-receptors-in-the-bed-nucleus-of-stria-terminalis-differently-modulate-the-baroreflex-function-in-unanesthetized-rats
#5
Leandro A Oliveira, Jeferson Almeida, Lucas Gomes-de-Souza, Ricardo Benini, Carlos C Crestani
The baroreflex is an important blood pressure regulating mechanism. The bed nucleus of stria terminalis (BNST) modulates the baroreflex function. However, the local BNST neurochemical mechanisms involved in control of baroreflex responses are not completely understood. Therefore, in the present study we investigated the involvement of corticotropin-releasing factor (CRF) receptors within the BNST in baroreflex control of heart rate in unanesthetized rats. For this, we evaluated effects of bilateral microinjection into the BNST of either the selective CRF1 receptor antagonist CP376395 (5nmol/100nL) or the selective CRF2 receptor antagonist antisauvagine-30 (5nmol/100nL) in bradycardiac response evoked by blood pressure increases caused by intravenous infusion of phenylephrine as well as tachycardiac response to blood pressure decrease caused by intravenous infusion of sodium nitroprusside...
June 14, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28609296/neuroanatomical-pathways-underlying-the-effects-of-hypothalamo-hypophysial-adrenal-hormones-on-exploratory-activity
#6
Robert Lalonde, Catherine Strazielle
When injected via the intracerebroventricular route, corticosterone-releasing hormone (CRH) reduced exploration in the elevated plus-maze, the center region of the open-field, and the large chamber in the defensive withdrawal test. The anxiogenic action of CRH in the elevated plus-maze also occurred when infused in the basolateral amygdala, ventral hippocampus, lateral septum, bed nucleus of the stria terminalis, nucleus accumbens, periaqueductal grey, and medial frontal cortex. The anxiogenic action of CRH in the defensive withdrawal test was reproduced when injected in the locus coeruleus, while the amygdala, hippocampus, lateral septum, nucleus accumbens, and lateral globus pallidus contribute to center zone exploration in the open-field...
June 13, 2017: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/28592900/white-matter-microstructural-changes-are-related-to-cognitive-dysfunction-in-essential-tremor
#7
Julián Benito-León, Virginia Mato-Abad, Elan D Louis, Juan Antonio Hernández-Tamames, Juan Álvarez-Linera, Félix Bermejo-Pareja, Ángela Domingo-Santos, Luis Collado, Juan Pablo Romero
Diffusion tensor imaging (DTI) studies have detected white matter microstructural changes in essential tremor (ET). However, it is still unclear whether these changes are related to cognitive deficits, which have been described in ET patients. DTI-derived fractional anisotropy, mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity measures were compared between 23 ET patients and 23 age-, gender-, and education-matched healthy individuals, using whole-brain tract-based spatial statistics. Correlations of white matter changes with scores obtained from a detailed neuropsychological assessment were subsequently examined...
June 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28589966/role-of-kappa-opioid-receptors-in-the-bed-nucleus-of-stria-terminalis-in-reinstatement-of-alcohol-seeking
#8
A D Lê, Douglas Funk, Kathleen Coen, Sahar Tamadon, Yavin Shaham
Kappa opioid receptors (KORs) and their endogenous ligand dynorphin are involved in stress-induced alcohol seeking but the mechanisms involved are largely unknown. We previously showed that systemic injections of the KOR agonist U50,488, which induce stress-like aversive states, reinstate alcohol seeking after extinction of the alcohol-reinforced responding. Here, we used the neuronal activity marker Fos and site-specific injections of the KOR antagonist nor-BNI and U50,488 to study brain mechanisms of U50,488-induced reinstatement of alcohol seeking...
June 7, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28578877/progression-of-changes-in-the-sensorial-elements-of-the-cochlear-and-peripheral-vestibular-systems-the-otitis-media-continuum
#9
Rafael da Costa Monsanto, Patricia Schachern, Michael M Paparella, Sebahattin Cureoglu, Norma de Oliveira Penido
Our study aimed to evaluate pathologic changes in the cochlear (inner and outer hair cells and stria vascularis) and vestibular (vestibular hair cells, dark, and transitional cells) sensorial elements in temporal bones from donors who had otitis media. We studied 40 temporal bones from such donors, which were categorized in serous otitis media (SOM), serous-purulent otitis media (SPOM), mucoid/mucoid-purulent otitis media (MOM/MPOM), and chronic otitis media (COM); control group comprised 10 nondiseased temporal bones...
May 26, 2017: Hearing Research
https://www.readbyqxmd.com/read/28576724/interaction-of-gaba-and-norepinephrine-in-the-lateral-division-of-the-bed-nucleus-of-the-stria-terminals-in-anesthetized-rat-correlating-single-unit-and-cardiovascular-responses
#10
Fahimeh Yeganeh, Ali Nasimi, Masoumeh Hatam
The bed nucleus of the stria terminalis (BST) consists of multiple anatomically distinct nuclei. The lateral division, which receives dense noradrenergic innervation, has been implicated in cardiovascular regulation and modulation of responses to stress. This study is performed to identify the cardiovascular and single-unit responses of the lateral BST to norepinephrine (NE), involved adrenoceptors, and possible interaction with GABAergic system of the BST in urethane-anesthetized rats. NE, adrenoreceptor antagonists, and GABAA antagonist were microinjected into the lateral division of BST, while arterial pressure (AP), heart rate (HR), and single-unit responses were simultaneously recorded...
May 31, 2017: Neuroscience
https://www.readbyqxmd.com/read/28555110/reduced-membrane-insertion-of-clc-k-by-v33l-barttin-results-in-loss-of-hearing-but-leaves-kidney-function-intact
#11
Hua Tan, Stefanie Bungert-Plümke, Christoph Fahlke, Gabriel Stölting
In the mammalian ear, transduction of sound stimuli is initiated by K(+) entry through mechano-sensitive channels into inner hair cells. K(+) entry is driven by a positive endocochlear potential that is maintained by the marginal cell layer of the stria vascularis. This process requires basolateral K(+) import by NKCC1 Na(+)-2Cl(-)-K(+) co-transporters as well as Cl(-) efflux through ClC-Ka/barttin or ClC-Kb/barttin channels. Multiple mutations in the gene encoding the obligatory CLC-K subunit barttin, BSND, have been identified in patients with Bartter syndrome type IV...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28543083/afferent-and-efferent-projections-of-the-anterior-cortical-amygdaloid-nucleus-in-the-mouse
#12
Bernardita Cádiz-Moretti, María Abellán-Álvaro, Cecília Pardo-Bellver, Fernando Martínez-García, Enrique Lanuza
The anterior cortical amygdaloid nucleus (ACo) is a chemosensory area of the cortical amygdala that receives afferent projections from both the main and accessory olfactory bulbs. The role of this structure is unknown, partially due to a lack of knowledge of its connectivity. In this work, we describe the pattern of afferent and efferent projections of the ACo by using fluorogold and biotinylated dextranamines as retrograde and anterograde tracers, respectively. The results show that the ACo is reciprocally connected with the olfactory system and basal forebrain, as well as with the chemosensory and basomedial amygdala...
May 23, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28539954/differential-histone-acetylation-in-sub-regions-of-bed-nucleus-of-the-stria-terminalis-underlies-fear-consolidation-and-extinction
#13
Vandana Ranjan, Sanjay Singh, Sarfraj Ahmad Siddiqui, Sukanya Tripathi, Mohd Yahiya Khan, Anand Prakash
OBJECTIVE: The hallmark of anxiety disorders is excessive fear. Previous studies have suggested that selective neural projections from Basal nucleus of stria terminalis (BNST) to amygdala and vice-versa precisely control the fear learning process. However the exact mechanism how the BNST controls fear consolidation and its extinction is largely unknown. In the present study we observed the changes in the BNST sub-regions following fear conditioning and its extinction. METHODS: The change in the number of positive neurons was determined by immunohistochemistry for Acetyl H3 (Histone 3), Acetyl H4 (Histone 4), cAMP response element binding Protein (CBP) and c-fos in three sub-regions of the BNST namely the anterio-lateral BNST (STLP) and anterio-medial BNST (STMA), and lateral-ventral BNST (STLV) of rats subjected to auditory fear conditioning and extinction...
May 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28539659/involvement-of-the-bed-nucleus-of-the-stria-terminalis-in-l-dopa-induced-dyskinesia
#14
Matthieu F Bastide, Christelle Glangetas, Evelyne Doudnikoff, Qin Li, Mathieu Bourdenx, Pierre-Olivier Fernagut, Éric C Dumont, François Georges, Erwan Bézard
A whole brain immediate early gene mapping highlighted the dorsolateral bed nucleus of the stria terminalis (dlBST) as a structure putatively involved in L-3,4-dihydroxyphenylalanine (L-Dopa)-induced dyskinesia (LID), the debilitating side-effects of chronic dopamine replacement therapy in Parkinson's disease (PD). dlBST indeed displayed an overexpression of ∆FosB, ARC, Zif268 and FRA2 only in dyskinetic rats. We thus hypothesized that dlBST could play a role in LID hyperkinetic manifestations. To assess the causal role of the dlBST in LID, we used Daun02 inactivation to selectively inhibit the electrical activity of dlBST ΔFosB-expressing neurons...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28528379/collateralization-of-projections-from-the-paraventricular-nucleus-of-the-thalamus-to-the-nucleus-accumbens-bed-nucleus-of-the-stria-terminalis-and-central-nucleus-of-the-amygdala
#15
Xinwen Dong, Sa Li, Gilbert J Kirouac
The paraventricular nucleus of the thalamus (PVT) is a midline thalamic nucleus with dense projections to the nucleus accumbens (NAc), dorsolateral region of the bed nucleus of the stria terminalis (BSTDL) and the lateral/capsular region of the central nucleus of the amygdala (CeL/CeC). Recent experimental evidence indicates that the PVT is involved in both appetitive and aversive behaviors. However, it is unknown if subgroups of neurons in the PVT innervate different subcortical targets or if the same neurons issue collaterals to multiple areas...
May 20, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28522214/p2-purinergic-receptor-antagonists-disrupt-maternal-behavior-in-lactating-rats
#16
Luciana C Teodoro, Layla D M Cabral, Fabiana C Vilela, Alexandre Giusti-Paiva
The involvement of purinergic signaling in several brain functions has been recognized, but the modulation on maternal behavior by the purinergic system is not established, even though there are functional interactions between the purinergic and oxytocinergic systems. Therefore, the aim of our study was to investigate whether central administration of P2 receptor antagonists affected the maternal behavior of lactating rats and c-Fos immunoreactivity in the forebrain. On day 7 of lactation, female rats were treated with vehicle (5μL; i...
July 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28502843/disentangling-the-effects-of-novelty-valence-and-trait-anxiety-in-the-bed-nucleus-of-the-stria-terminalis-amygdala-and-hippocampus-with-high-resolution-7t-fmri
#17
Walker S Pedersen, L Tugan Muftuler, Christine L Larson
The hippocampus and amygdala exhibit sensitivity to stimulus novelty that is reduced in participants with inhibited temperament, which is related to trait anxiety. Although the bed nucleus of the stria terminalis (BNST) is highly connected to the amygdala and is implicated in anxiety, whether the BNST responds to novelty remains unstudied, as well as how trait anxiety may modulate this response. Additionally how novelty, stimulus negativity and trait anxiety interact to affect activity in these areas is also unclear...
May 11, 2017: NeuroImage
https://www.readbyqxmd.com/read/28502529/mechanisms-underlying-the-early-risk-to-develop-anxiety-and-depression-a-translational-approach
#18
REVIEW
Ned H Kalin
Anxious temperament (AT) is an early life disposition that markedly increases the risk to develop stress related psychopathology such as anxiety and depressive disorders. Since anxiety and depression are common, and frequently have their onset early in life, a better understanding of the factors related to their childhood onset will facilitate the development of new more effective neurally informed interventions. A nonhuman primate (NHP) developmental model of childhood AT has been established, which has provided an understanding of the neural systems and molecular mechanisms mediating the development of AT...
June 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28502391/bed-nucleus-of-the-stria-terminalis-derived-corticotropin-releasing-factor-controls-binge-alcohol-drinking-via-interacting-with-corticotropin-releasing-factor-receptors-1-and-2-in-the-ventral-tegmental-area
#19
https://www.readbyqxmd.com/read/28485259/distinct-phasic-and-sustained-brain-responses-and-connectivity-of-amygdala-and-bed-nucleus-of-the-stria-terminalis-during-threat-anticipation-in-panic-disorder
#20
L Brinkmann, C Buff, K Feldker, S V Tupak, M P I Becker, M J Herrmann, T Straube
BACKGROUND: Panic disorder (PD) patients are constantly concerned about future panic attacks and exhibit general hypersensitivity to unpredictable threat. We aimed to reveal phasic and sustained brain responses and functional connectivity of the amygdala and the bed nucleus of the stria terminalis (BNST) during threat anticipation in PD. METHODS: Using functional magnetic resonance imaging (fMRI), we investigated 17 PD patients and 19 healthy controls (HC) during anticipation of temporally unpredictable aversive and neutral sounds...
May 9, 2017: Psychological Medicine
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