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https://www.readbyqxmd.com/read/28715355/repeated-exposure-to-sucrose-for-procedural-pain-in-mouse-pups-leads-to-long-term-widespread-brain-alterations
#1
Sophie Tremblay, Manon Ranger, Cecil M Y Chau, Jacob Ellegood, Jason P Lerch, Liisa Holsti, Daniel Goldowitz, Ruth E Grunau
Oral sucrose is administered routinely to reduce pain of minor procedures in premature infants and is recommended as standard care in international guidelines. No human or animal studies on effects of early repeated sucrose exposure on long-term brain development have been done in the context of pain. We evaluated the effects of repeated neonatal sucrose treatment before an intervention on long-term brain structure in mouse pups. Neonatal C57Bl/6J mice (n = 109) were randomly assigned to one of 2 treatments (vehicle vs sucrose) and one of 3 interventions (handling, touch, or needle-prick)...
August 2017: Pain
https://www.readbyqxmd.com/read/28714716/cb%C3%A2-receptor-antagonism-in-the-bed-nucleus-of-the-stria-terminalis-interferes-with-affective-opioid-withdrawal-in-rats
#2
Kiri L Wills, Marieka V DeVuono, Cheryl L Limebeer, Kiran Vemuri, Alexandros Makriyannis, Linda A Parker
The bed nucleus of the stria terminalis (BNST) is a region of the extended amygdala that is implicated in addiction, anxiety, and stress related behaviors. This region has been identified in mediating the aversive state of naloxone-precipitated morphine withdrawal (MWD) and cannabinoid Type I (CB1) receptors have been found to modulate neurotransmission within this region. Previous findings suggest that the CB1 antagonist/inverse agonist, AM251, administered systemically or by infusion into the central nucleus of the amygdala (CeA) prevented the aversive affective properties of MWD as measured by conditioned place aversion learning...
August 2017: Behavioral Neuroscience
https://www.readbyqxmd.com/read/28703809/epigallocatechin-3-gallate-a-prototypic-chemopreventative-agent-for-protection-against-cisplatin-based-ototoxicity
#3
Vikrant Borse, Raheem F H Al Aameri, Kelly Sheehan, Sandeep Sheth, Tejbeer Kaur, Debashree Mukherjea, Srinivasan Tupal, Michelle Lowy, Sumana Ghosh, Asmita Dhukhwa, Puspanjali Bhatta, Leonard P Rybak, Vickram Ramkumar
Cisplatin-induced ototoxicity is one of the major factors limiting cisplatin chemotherapy. Ototoxicity results from damage to outer hair cells (OHCs) and other regions of the cochlea. At the cellular level, cisplatin increases reactive oxygen species (ROS) leading to cochlear inflammation and apoptosis. Thus, ideal otoprotective drugs should target oxidative stress and inflammatory mechanisms without interfering with cisplatin's chemotherapeutic efficacy. In this study, we show that epigallocatechin-3-gallate (EGCG) is a prototypic agent exhibiting these properties of an effect otoprotective agent...
July 13, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28701225/association-of-schizophrenia-onset-age-and-white-matter-integrity-with-treatment-effect-of-d-cycloserine-a-randomized-placebo-controlled-double-blind-crossover-study
#4
Kazuo Takiguchi, Akihito Uezato, Michio Itasaka, Hidenori Atsuta, Kenji Narushima, Naoki Yamamoto, Akeo Kurumaji, Makoto Tomita, Kazunari Oshima, Kosaku Shoda, Mai Tamaru, Masahito Nakataki, Mitsutoshi Okazaki, Sayuri Ishiwata, Yasuyoshi Ishiwata, Masato Yasuhara, Kunimasa Arima, Tetsuro Ohmori, Toru Nishikawa
BACKGROUND: It has been reported that drugs which promote the N-Methyl-D-aspartate-type glutamate receptor function by stimulating the glycine modulatory site in the receptor improve negative symptoms and cognitive dysfunction in schizophrenia patients being treated with antipsychotic drugs. METHODS: We performed a placebo-controlled double-blind crossover study involving 41 schizophrenia patients in which D-cycloserine 50 mg/day was added-on, and the influence of the onset age and association with white matter integrity on MR diffusion tensor imaging were investigated for the first time...
July 12, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28699305/enhancement-of-the-lh-surge-by-male-olfactory-signals-is-associated-with-avpv-kiss1-cell-activation-in-female-rats
#5
Youki Watanabe, Kana Ikegami, Ren Ishigaki, Nahoko Ieda, Yoshihisa Uenoyama, Kei-Ichiro Maeda, Hiroko Tsukamura, Naoko Inoue
Olfactory stimuli play an important role in regulating reproductive functions in mammals. The present study investigated the effect of olfactory signals derived from male rats on kisspeptin neuronal activity and luteinizing hormone (LH) secretion in female rats. Wistar-Imamichi strain female rats were ovariectomised (OVX) and implanted with preovulatory levels of oestradiol-17β (E2). OVX+E2 rats were sacrificed 1 hour after exposure to either: clean bedding, female-soiled bedding or male-soiled bedding. Dual staining for Kiss1 mRNA in situ hybridization and c-Fos immunohistochemistry revealed that the numbers of Kiss1-expressing cells and c-Fos-immunopositive Kiss1-expressing cells in the anteroventral periventricular nucleus (AVPV) were significantly higher in OVX+E2 rats exposed to male-soiled bedding than those of the other groups...
July 12, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28695319/acute-impact-of-selected-pyridoindole-derivatives-on-fos-expression-in-different-structures-of-the-rat-brain
#6
Romana Koprdova, Jana Osacka, Mojmir Mach, Alexander Kiss
The impacts of three pyridoindole derivatives (PDs), designated as PD144, PD143, and PD104, which have previously been shown to have antidepressant (PD144) and anxiolytic (PD143, PD104) properties, were investigated on the Fos expressions in 11 different rat brain areas, including the medial prefrontal cortex, striatum, septum, accumbens nucleus (shell, core), bed nucleus of the stria terminalis, hypothalamic paraventricular nucleus, central amygdala, locus coeruleus, dorsal raphe nucleus, and the solitary tract nucleus...
July 10, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28694172/macrophage-migration-inhibitory-factor-mediates-viability-and-apoptosis-of-pvm-ms-through-pi3k-akt-pathway
#7
Wenjing Zhang, Jian Zheng, Juan Meng, Lingling Neng, Xiaohua Chen, Zhaobing Qin
Macrophage migration inhibitory factor (MIF) plays an important role in hearing function; however, the underlying mechanism remains indistinct. PVM/Ms from the stria vascularis of lateral wall of cochlea in young and aged mice were isolated, and the mRNA and protein expression levels were detected. MIF was knocked down or overexpresssed in vitro, and transfection was performed in vivo. Cell viability and apoptosis were determined by MTT assay and flow cytometry analysis, respectively. The hearing ability was tested by the auditory brain stem response...
July 8, 2017: Neuroscience
https://www.readbyqxmd.com/read/28687930/spatiotemporal-expression-patterns-of-clusterin-in-the-mouse-inner-ear
#8
Seokwon Lee, Jeong-Oh Shin, Borum Sagong, Un-Kyung Kim, Jinwoong Bok
Clusterin (CLU) is an extracellular chaperone protein that is implicated in diverse physiological and pathophysiological cellular processes. CLU expression is upregulated in response to cellular stress and under certain conditions, such as neurodegenerative disease and cancer. CLU primarily functions as a chaperone that exerts cytoprotective effects by removing cellular debris and misfolded proteins and also acts as a signaling molecule that regulates pro-survival pathways. Deafness is caused by genetic factors and various extrinsic insults, including ototoxic drugs, exposure to loud sounds and aging...
July 8, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28671956/a-multiscale-cerebral-neurochemical-connectome-of-the-rat-brain
#9
Hamid R Noori, Judith Schöttler, Maria Ercsey-Ravasz, Alejandro Cosa-Linan, Melinda Varga, Zoltan Toroczkai, Rainer Spanagel
Understanding the rat neurochemical connectome is fundamental for exploring neuronal information processing. By using advanced data mining, supervised machine learning, and network analysis, this study integrates over 5 decades of neuroanatomical investigations into a multiscale, multilayer neurochemical connectome of the rat brain. This neurochemical connectivity database (ChemNetDB) is supported by comprehensive systematically-determined receptor distribution maps. The rat connectome has an onion-type structural organization and shares a number of structural features with mesoscale connectomes of mouse and macaque...
July 2017: PLoS Biology
https://www.readbyqxmd.com/read/28657115/monosynaptic-retrograde-tracing-of-neurons-expressing-the-g-protein-coupled-receptor-gpr151-in-the-mouse-brain
#10
Jonas Broms, Matilda Grahm, Lea Haugegaard, Thomas Blom, Konstantinos Meletis, Anders Tingström
GPR151 is a G-protein coupled receptor for which the endogenous ligand remains unknown. In the nervous system of vertebrates, its expression is enriched in specific diencephalic structures, where the highest levels are observed in the habenular area. The habenula has been implicated in a range of different functions including behavioral flexibility, decision making, inhibitory control and pain processing, which makes it a promising target for treating psychiatric and neurological disease. This study aimed to further characterize neurons expressing the Gpr151 gene, by tracing the afferent connectivity of this diencephalic cell population...
June 28, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28656976/pituitary-adenylate-cyclase-activating-peptide-in-the-bed-nucleus-of-the-stria-terminalis-mediates-stress-induced-reinstatement-of-cocaine-seeking-in-rats
#11
Olivia W Miles, Eric A Thrailkill, Anne K Linden, Victor May, Mark E Bouton, Sayamwong E Hammack
Stressors often contribute to difficulties in maintaining behavior change following a period of abstinence, and may play a significant role in drug relapse. The activation of pituitary adenylate cyclase activating peptide (PACAP) systems in the bed nucleus of the stria terminalis (BNST) mediates many consequences of chronic stressor exposure. Here we ask whether PACAP is also involved in producing reinstatement in a model of stress-induced relapse to drug taking. Rats self-administered cocaine for 1hr daily over 10 days, which was followed by 20 days of extinction training in which lever pressing no longer produced cocaine...
June 28, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28649992/a-key-role-for-neurotensin-in-chronic-stress-induced-anxiety-like-behaviour-in-rats
#12
Catherine P Normandeau, Ana Paula Ventura Silva, Emily R Hawken, Staci Angelis, Calvin Sjaarda, Xudong Liu, José Miguel Pêgo, Éric C Dumont
Chronic stress is a major cause of anxiety disorders that can be reliably modeled pre-clinically, providing insight into alternative therapeutic targets for this mental health illness. Neuropeptides have been targeted in the past to no avail possibly due to our lack of understanding of their role in pathological models. In this study we use a rat model of chronic stress-induced anxiety-like behaviours and hypothesized that neuropeptidergic modulation of synaptic transmission would be altered in the Bed Nucleus of the Stria Terminalis (BNST), a brain region suspected to contribute to anxiety disorders...
June 26, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28642284/excitation-of-gabaergic-neurons-in-the-bed-nucleus-of-the-stria-terminalis-triggers-immediate-transition-from-non-rapid-eye-movement-sleep-to-wakefulness-in-mice
#13
Shota Kodani, Shingo Soya, Takeshi Sakurai
Emotionally salient situations usually trigger arousal along with autonomic and neuroendocrine reactions. To examine whether the extended amygdala plays a role in sleep/wakefulness regulation, we examined the effects of optogenetic and pharmacogenetic excitation of GABAergic neurons in the bed nucleus of the stria terminalis (GABA(BNST) neurons). Acute optogenetic excitation of these cells during non-rapid eye movement (NREM) sleep resulted in immediate state transition to wakefulness, while stimulation during rapid eye movement (REM) sleep showed no effect on sleep/wakefulness states in male mice...
June 22, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28627704/matrix-metalloproteinase-2-and-9-contribute-to-functional-integrity-and-noise%C3%A2-induced-damage-to-the-blood-labyrinth-barrier
#14
Jun Wu, Weiju Han, Xingrui Chen, Weiwei Guo, Ke Liu, Ruoya Wang, Jishuai Zhang, Na Sai
The cochlear blood-labyrinth barrier (BLB), located in the stria vascularis, is critical for the homeostasis of cochlear solutes and ion transport. Significant disruption to the BLB occurs early during noise‑induced hearing loss. Matrix metalloproteinase (MMP)‑2 and ‑9 are important molecules known to be capable of degrading tight junction (TJ) proteins. The TJ proteins are important components of the extracellular matrix (ECM), required to maintain BLB integrity and permeability. Previous studies have demonstrated that MMP‑2 and ‑9, rich in healthy cochlea, serve an essential role in regulating the cochlear response to acoustic trauma...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28625549/the-long-term-effects-of-stress-and-kappa-opioid-receptor-activation-on-conditioned-place-aversion-in-male-and-female-california-mice
#15
Abigail R Laman-Maharg, Tiffany Copeland, Evelyn Ordoñes Sanchez, Katharine L Campi, Brian C Trainor
Psychosocial stress leads to the activation of kappa opioid receptors (KORs), which induce dysphoria and facilitate depression-like behaviors. However, less is known about the long-term effects of stress and KORs in females. We examined the long-term effects of social defeat stress on the aversive properties of KOR activation in male and female California mice (Peromyscus californicus) using a conditioned place aversion paradigm. Female California mice naïve to social defeat, formed a place aversion following treatment with 2...
June 15, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28614607/anatomical-and-functional-implications-of-crh-neurons-in-a-septal-nucleus-of-the-avian-brain-an-emphasis-on-glial-neuronal-interaction-via-v1a-receptors-in-vitro
#16
Gurueswar Nagarajan, Alexander Jurkevich, Seong W Kang, Wayne J Kuenzel
Previously, we showed that corticotropin releasing hormone immunoreactive (CRH-ir) neurons in a septal structure are associated with stress and the hypothalamo-pituitary-adrenal axis in birds. In this study, we focused upon CRH-ir neurons located within the septal structure called the nucleus of the hippocampal commissure (NHpC). Immunocytochemical and gene expression analyses were used to identify the anatomical and functional characteristics of cells within the NHpC. A comparative morphometry analysis showed that CRH-ir neurons in the NHpC were significantly larger than CRH-ir parvocellular neurons in the paraventricular nucleus of the hypothalamus (PVN) and lateral bed nucleus of the stria terminalis...
June 14, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28612996/crf1-and-crf2-receptors-in-the-bed-nucleus-of-stria-terminalis-differently-modulate-the-baroreflex-function-in-unanesthetized-rats
#17
Leandro A Oliveira, Jeferson Almeida, Lucas Gomes-de-Souza, Ricardo Benini, Carlos C Crestani
The baroreflex is an important blood pressure regulating mechanism. The bed nucleus of stria terminalis (BNST) modulates the baroreflex function. However, the local BNST neurochemical mechanisms involved in control of baroreflex responses are not completely understood. Therefore, in this study, we investigated the involvement of corticotropin-releasing factor (CRF) receptors within the BNST in baroreflex control of heart rate in unanesthetized rats. For this, we evaluated effects of bilateral microinjection into the BNST of either the selective CRF1 receptor antagonist CP376395 (5 nmol/100 nL) or the selective CRF2 receptor antagonist antisauvagine-30 (5 nmol/100 nL) in bradycardiac response evoked by blood pressure increases caused by intravenous infusion of phenylephrine as well as tachycardiac response to blood pressure decrease caused by intravenous infusion of sodium nitroprusside...
June 14, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28609296/neuroanatomical-pathways-underlying-the-effects-of-hypothalamo-hypophysial-adrenal-hormones-on-exploratory-activity
#18
Robert Lalonde, Catherine Strazielle
When injected via the intracerebroventricular route, corticosterone-releasing hormone (CRH) reduced exploration in the elevated plus-maze, the center region of the open-field, and the large chamber in the defensive withdrawal test. The anxiogenic action of CRH in the elevated plus-maze also occurred when infused in the basolateral amygdala, ventral hippocampus, lateral septum, bed nucleus of the stria terminalis, nucleus accumbens, periaqueductal grey, and medial frontal cortex. The anxiogenic action of CRH in the defensive withdrawal test was reproduced when injected in the locus coeruleus, while the amygdala, hippocampus, lateral septum, nucleus accumbens, and lateral globus pallidus contribute to center zone exploration in the open-field...
June 13, 2017: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/28592900/white-matter-microstructural-changes-are-related-to-cognitive-dysfunction-in-essential-tremor
#19
Julián Benito-León, Virginia Mato-Abad, Elan D Louis, Juan Antonio Hernández-Tamames, Juan Álvarez-Linera, Félix Bermejo-Pareja, Ángela Domingo-Santos, Luis Collado, Juan Pablo Romero
Diffusion tensor imaging (DTI) studies have detected white matter microstructural changes in essential tremor (ET). However, it is still unclear whether these changes are related to cognitive deficits, which have been described in ET patients. DTI-derived fractional anisotropy, mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity measures were compared between 23 ET patients and 23 age-, gender-, and education-matched healthy individuals, using whole-brain tract-based spatial statistics. Correlations of white matter changes with scores obtained from a detailed neuropsychological assessment were subsequently examined...
June 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28589966/role-of-%C3%AE%C2%BA-opioid-receptors-in-the-bed-nucleus-of-stria-terminalis-in-reinstatement-of-alcohol-seeking
#20
A D Lê, Douglas Funk, Kathleen Coen, Sahar Tamadon, Yavin Shaham
κ-Opioid receptors (KORs) and their endogenous ligand dynorphin are involved in stress-induced alcohol seeking but the mechanisms involved are largely unknown. We previously showed that systemic injections of the KOR agonist U50,488, which induce stress-like aversive states, reinstate alcohol seeking after extinction of the alcohol-reinforced responding. Here, we used the neuronal activity marker Fos and site-specific injections of the KOR antagonist nor-BNI and U50,488 to study brain mechanisms of U50,488-induced reinstatement of alcohol seeking...
June 7, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
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