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https://www.readbyqxmd.com/read/29221794/glp-1-action-in-the-mouse-bed-nucleus-of-the-stria-terminalis
#1
Diana L Williams, Nicole A Lilly, Ian J Edwards, Pallas Yao, James E Richards, Stefan Trapp
Glucagon-like peptide-1 (GLP-1) injected into the brain reduces food intake. Similarly, activation of preproglucagon (PPG) cells in the hindbrain which synthesize GLP-1, reduces food intake. However, it is far from clear whether this happens because of satiety, nausea, reduced reward, or even stress. Here we explore the role of the bed nucleus of the stria terminalis (BNST), an area involved in feeding control as well as stress responses, in GLP-1 responses. Using cre-expressing mice we visualized projections of NTS PPG neurons and GLP-1R-expressing BNST cells with AAV-driven Channelrhodopsin-YFP expression...
December 5, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29209769/different-behavioral-neural-and-neuropeptide-responses-of-fathers-to-their-own-and-to-alien-pups-in-mandarin-voles
#2
Wei Yuan, Xiang-Ping Yang, Peng Yu, Rui Jia, Fa-Dao Tai, Bin Wei, Xiao Liu, Lei-Ge Ma
Mothers often prefer to care for their own offspring rather than those of other females. However, whether fathers respond differently to their own pups and to alien ones remains unclear. In this study, we found that male mandarin voles (Microtus mandarinus) directed more sniffing toward their own pups than toward alien pups. The numbers of Fos-immunoreactive neurons in the medial preoptic nucleus, bed nucleus of the stria terminalis, nucleus accumbens, anterior cingulate cortex were significantly increased when fathers were exposed to an alien pups; however, more brain regions such as paraventricular nucleus, hypothalamic supraoptic nucleus, lateral habenula, ventral lateral septal nucleus, and medial amygdaloid nucleus showed increased number of Fos-immunoreactive neurons activated when the fathers were exposed to their own pups...
December 5, 2017: Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
https://www.readbyqxmd.com/read/29209184/dynamics-of-intersubject-brain-networks-during-anxious-anticipation
#3
Mahshid Najafi, Joshua Kinnison, Luiz Pessoa
How do large-scale brain networks reorganize during the waxing and waning of anxious anticipation? Here, threat was dynamically modulated during human functional MRI as two circles slowly meandered on the screen; if they touched, an unpleasant shock was delivered. We employed intersubject correlation analysis, which allowed the investigation of network-level functional connectivity across brains, and sought to determine how network connectivity changed during periods of approach (circles moving closer) and periods of retreat (circles moving apart)...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29205599/postnatal-separation-prevents-the-development-of-prenatal-stress-induced-anxiety-in-association-with-changes-in-estrogen-receptor-and-oxytocin-immunoreactivity-in-female-mandarin-vole-microtus-mandarinus-offspring
#4
Fengqin He, Zijian Wang, Guanlin Guo
Estrogen has both anxiogenic and anxiolytic effects because of variation in opposing action on alpha (ERα) and beta (ERβ) estrogen receptors in the medial preoptic area (mPOA), bed nucleus of the stria terminalis (BNST) and medial amygdala (MeA). Oxytocin (OT) reverses some of the anxiogenic effects of estrogen in the hypothalamic paraventricular nucleus (PVN) and supraoptic nucleus (SON). Because anxiety disorders are twice as common in women as in men, and estrogen and OT are more important in females, we examined interactions between prenatal restraint stress (GS) and postnatal early short-term maternal separation (MS) and female mandarin vole behavior, estrogen receptors and OT...
December 4, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29203852/the-dynamics-of-stress-a-longitudinal-mri-study-of-rat-brain-structure-and-connectome
#5
R Magalhães, D A Barrière, A Novais, F Marques, P Marques, J Cerqueira, J C Sousa, A Cachia, F Boumezbeur, M Bottlaender, T M Jay, S Mériaux, N Sousa
Stress is a well-established trigger for a number of neuropsychiatric disorders, as it alters both structure and function of several brain regions and its networks. Herein, we conduct a longitudinal neuroimaging study to assess how a chronic unpredictable stress protocol impacts the structure of the rat brain and its functional connectome in both high and low responders to stress. Our results reveal the changes that stress triggers in the brain, with structural atrophy affecting key regions such as the prelimbic, cingulate, insular and retrosplenial, somatosensory, motor, auditory and perirhinal/entorhinal cortices, the hippocampus, the dorsomedial striatum, nucleus accumbens, the septum, the bed nucleus of the stria terminalis, the thalamus and several brain stem nuclei...
December 5, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29199095/analysis-of-white-matter-characteristics-with-tract-based-spatial-statistics-according-to-diffusion-tensor-imaging-in-early-parkinson-s-disease
#6
Xiang-Rong Li, Yan-De Ren, Bo Cao, Xuan-Li Huang
OBJECTIVE: To analyze the microstructure of brain white matter according to diffusion tensor imaging (DTI) based on tract-based spatial statistics (TBSS) in early Parkinson's disease (PD). MATERIALS AND METHODS: A total of 31 age- and sex-matched early PD patients and 22 healthy volunteers were recruited in the present study. DTI was performed, and the data analyzed with fsl4.0 software. The fractional anisotropy (FA) was compared between both groups with an independent t test, and the differential area was analyzed...
November 30, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29195911/the-central-extended-amygdala-in-fear-and-anxiety-closing-the-gap-between-mechanistic-and-neuroimaging-research
#7
REVIEW
Andrew S Fox, Alexander J Shackman
Anxiety disorders impose a staggering burden on public health, underscoring the need to develop a deeper understanding of the distributed neural circuits underlying extreme fear and anxiety. Recent work highlights the importance of the central extended amygdala, including the central nucleus of the amygdala (Ce) and neighboring bed nucleus of the stria terminalis (BST). Anatomical data indicate that the Ce and BST form a tightly interconnected unit, where different kinds of threat-relevant information can be integrated to assemble states of fear and anxiety...
November 30, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29186377/oxytocin-oxytocin-receptor-systems-facilitate-social-defeat-posture-in-male-mice
#8
Naranbat Nasanbuyan, Masahide Yoshida, Yuki Takayanagi, Ayumu Inutsuka, Katsuhiko Nishimori, Akihiro Yamanaka, Tatsushi Onaka
Social stress has deteriorating effects on various psychiatric diseases. In animal models, exposure to socially dominant conspecifics, i.e., social defeat stress, evokes species-specific defeat posture via unknown mechanisms. Oxytocin neurons have been shown to be activated by stressful stimuli and to have pro-social and anxiolytic actions. The roles of oxytocin during social defeat stress remain unclear. Expression of c-Fos, a marker of neuronal activation, in oxytocin neurons and in oxytocin receptor-expressing neurons was investigated in mice...
November 24, 2017: Endocrinology
https://www.readbyqxmd.com/read/29177631/manipulating-an-internal-pulse-generator-until-twiddler-s-syndrome-in-a-patient-treated-with-deep-brain-stimulation-for-obsessive-compulsive-disorder
#9
Andrea Franzini, Rebecca Ranieri, Orsola Gambini, Giuseppe Messina
BACKGROUND: Twiddler's syndrome consists of rotation or manipulation of an implantable pulse generator (IPG) in its subcutaneous pocket by a patient, thus causing hardware malfunction. METHODS: This syndrome is being reported more frequently in patients treated with deep brain stimulation (DBS). RESULTS: We report the case of a woman who had received bed nucleus of stria terminalis (BNST) electrodes for obsessive-compulsive disorder (OCD) and developed twiddler's syndrome a few months after surgery, causing hardware malfunction due to obsessive manipulation of the IPG...
November 25, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29169825/nitric-oxide-cgmp-pkg-signaling-in-the-bed-nucleus-of-the-stria-terminalis-modulates-the-cardiovascular-responses-to-stress-in-male-rats
#10
Lucas Barretto-de-Souza, Mariane B Adami, Leandro A Oliveira, Lucas Gomes-de-Souza, Josiane O Duarte, Jeferson Almeida, Carlos C Crestani
The bed nucleus of the stria terminalis (BNST) constitutes an important component of neural substrates of physiological and behavioral responses to aversive stimuli, and it has been implicated on cardiovascular responses evoked by stress. Nevertheless, the local neurochemical mechanisms involved in BNST control of cardiovascular responses during aversive threats are still poorly understood. Thus, the aim of the present study was to assess the involvement of activation in the BNST of the neuronal isoform of the enzyme nitric oxide synthase (nNOS), as well as of signaling mechanisms related to nitric oxide effects such as soluble guanylate cyclase (sGC) and protein kinase G (PKG) on cardiovascular responses induced by an acute session of restraint stress in male rats...
November 20, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29165653/transgenerational-effects-of-bisphenol-a-on-gene-expression-and-dna-methylation-of-imprinted-genes-in-brain
#11
Zuzana Drobná, Anne D Henriksen, Jennifer T Wolstenholme, Catalina Montiel, Philip S Lambeth, Stephen Shang, Erin P Harris, Changqing Zhou, Jodi A Flaws, Mazhar Adli, Emilie F Rissman
Bisphenol A (BPA) is a ubiquitous man-made endocrine disrupting compound (EDC). Developmental exposure to BPA changes behavioral and reproductive phenotypes and these effects can last for generations. We exposed embryos to BPA producing two lineages: controls and BPA-exposed. In the third generation (F3), brain tissues containing the preoptic area, the bed nucleus of the stria terminalis, and the anterior hypothalamus were collected. RNA sequencing (RNA-Seq) and subsequent data analyses revealed 50 differentially regulated genes in the brains of F3 juveniles from BPA- versus control-lineages...
November 17, 2017: Endocrinology
https://www.readbyqxmd.com/read/29163108/alterations-in-white-matter-integrity-in-young-adults-with-smartphone-dependence
#12
Yuanming Hu, Xiaojing Long, Hanqing Lyu, Yangyang Zhou, Jianxiang Chen
Smartphone dependence (SPD) is increasingly regarded as a psychological problem, however, the underlying neural substrates of SPD is still not clear. High resolution magnetic resonance imaging provides a useful tool to help understand and manage the disorder. In this study, a tract-based spatial statistics (TBSS) analysis on diffusion tensor imaging (DTI) was used to measure white matter integrity in young adults with SPD. A total of 49 subjects were recruited and categorized into SPD and control group based on their clinical behavioral tests...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29162831/cisplatin-is-retained-in-the-cochlea-indefinitely-following-chemotherapy
#13
Andrew M Breglio, Aaron E Rusheen, Eric D Shide, Katharine A Fernandez, Katie K Spielbauer, Katherine M McLachlin, Matthew D Hall, Lauren Amable, Lisa L Cunningham
Cisplatin chemotherapy causes permanent hearing loss in 40-80% of treated patients. It is unclear whether the cochlea has unique sensitivity to cisplatin or is exposed to higher levels of the drug. Here we use inductively coupled plasma mass spectrometry (ICP-MS) to examine cisplatin pharmacokinetics in the cochleae of mice and humans. In most organs cisplatin is detected within one hour after injection, and is eliminated over the following days to weeks. In contrast, the cochlea retains cisplatin for months to years after treatment in both mice and humans...
November 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/29162178/childhood-maltreatment-moderates-the-effect-of-combat-exposure-on-cingulum-structural-integrity
#14
Layla Banihashemi, Meredith L Wallace, Lei K Sheu, Michael C Lee, Peter J Gianaros, Robert P Mackenzie, Salvatore P Insana, Anne Germain, Ryan J Herringa
Limbic white matter pathways link emotion, cognition, and behavior and are potentially malleable to the influences of traumatic events throughout development. However, the impact of interactions between childhood and later life trauma on limbic white matter pathways has yet to be examined. Here, we examined whether childhood maltreatment moderated the effect of combat exposure on diffusion tensor imaging measures within a sample of military veterans (N = 28). We examined five limbic tracts of interest: two components of the cingulum (cingulum, cingulate gyrus, and cingulum hippocampus [CGH]), the uncinate fasciculus, the fornix/stria terminalis, and the anterior limb of the internal capsule...
December 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/29160374/study-of-the-protective-effect-of-dexamethasone-on-cisplatin-induced-ototoxicity-in-rats
#15
Isabelle Oliveira Jatai Capelo, Avner Marcos Alves Batista, Yuri Neyson Ferreira Brito, Krissia Braga Diniz, Gerly Anne de Castro Brito, Marcos Rabelo de Freitas
PURPOSE: To evaluate the ability of dexamethasone to protect against cisplatin (CDDP)-induced ototoxicity. METHODS: Male Wistar rats were divided into the following three groups: 1) Control (C): 6 animals received intraperitoneal (IP) saline solution, 8 ml/kg/day for four days; 2) C + CDDP: 11 animals received 8 ml/kg/day of IP saline and, 90 min after saline administration, 8 mg/kg/day of IP CDDP for four days; and 3) DEXA15 + CDDP: 11 animals received IP dexamethasone 15 mg/kg/day and, 90 min after dexamethasone administration, received 8 mg/kg/day of IP CDDP for four days...
October 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29135875/cochlear-pericytes-are-capable-of-reversibly-decreasing-capillary-diameter-in-vivo-after-tumor-necrosis-factor-exposure
#16
Mattis Bertlich, Friedrich Ihler, Bernhard G Weiss, Saskia Freytag, Michael Strupp, Martin Canis
OBJECTIVE: The aim of this work was to evaluate the effect of tumor necrosis factor (TNF) and its neutralization with etanercept on the capability of cochlear pericytes to alter capillary diameter in the stria vascularis. METHODS: Twelve Dunkin-Hartley guinea pigs were randomly assigned to one of three groups. Each group was treated either with placebo and then placebo, TNF and then placebo, or TNF and then etanercept. Cochlear pericytes were visualized using diaminofluorescein-2-diacetate and intravasal blood flow by fluorescein-dextrane...
December 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29131433/suppressive-effects-of-morphine-injected-into-the-ventral-bed-nucleus-of-the-stria-terminalis-on-the-affective-but-not-sensory-component-of-pain-in-rats
#17
Chikashi Maruyama, Satoshi Deyama, Yusuke Nagano, Soichiro Ide, Katsuyuki Kaneda, Mitsuhiro Yoshioka, Masabumi Minami
Pain is a complex experience with both sensory and affective components. Clinical and preclinical studies have shown that the affective component of pain can be reduced by doses of morphine lower than those necessary to reduce the sensory component. Although the neural mechanisms underlying the effects of morphine on the sensory component of pain have been investigated extensively, those influencing the affective component remain to be elucidated. The bed nucleus of the stria terminalis (BNST) has been implicated in the regulation of various negative emotional states, including aversion, anxiety, and fear...
November 13, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29126127/conservatism-and-the-neural-circuitry-of-threat-economic-conservatism-predicts-greater-amygdala-bnst-connectivity-during-periods-of-threat-vs-safety
#18
Walker S Pedersen, L Tugan Muftuler, Christine L Larson
Political conservatism is associated with an increased negativity bias, including increased attention and reactivity toward negative and threatening stimuli. Although the amygdala has been implicated in the human response to threatening stimuli, no studies to date have investigated whether conservatism is associated with altered amygdala function toward threat. Furthermore, although an influential theory (Davis et al., 2010) posits that connectivity between the amygdala and bed nucleus of the stria terminalis (BNST) is important in initiating the response to sustained or uncertain threat, whether individual differences in conservatism modulate this connectivity is unknown...
November 6, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/29124350/role-of-trh-ucn3-neurons-of-the-perifornical-area-bed-nucleus-of-stria-terminalis-region-in-the-regulation-of-the-anorexigenic-pomc-neurons-of-the-arcuate-nucleus-in-male-mice-and-rats
#19
Zoltán Péterfi, Erzsébet Farkas, Kata Nagyunyomi-Sényi, Andrea Kádár, Szenci Ottó, András Horváth, Tamás Füzesi, Ronald M Lechan, Csaba Fekete
Two anorexigenic peptides, thyrotropin-releasing hormone (TRH) and urocortin 3 (UCN3), are co-expressed in a continuous neuronal group that extends from the perifornical area to the bed nucleus of stria terminalis, raising the possibility that this cell group may be involved in the regulation of energy homeostasis. In this study, therefore, we tested the hypothesis that the TRH/UCN3 neurons regulate food intake by influencing feeding-related neuropeptide Y (NPY) and/or proopiomelanocortin (POMC) neurons in the arcuate nucleus (ARC)...
November 9, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/29118713/corticotropin-releasing-factor-in-the-bed-nucleus-of-the-stria-terminalis-in-socially-defeated-and-non-stressed-mice-with-a-history-of-chronic-alcohol-intake
#20
Lucas Albrechet-Souza, Thiago W Viola, Rodrigo Grassi-Oliveira, Klaus A Miczek, Rosa M M de Almeida
Stress exposure has been identified as one risk factor for alcohol abuse that may facilitate the transition from social or regulated use to the development of alcohol dependence. Preclinical studies have shown that dysregulation of the corticotropin releasing factor (CRF) neurotransmission has been implicated in stress-related psychopathologies such as depression and anxiety, and may affect alcohol consumption. The bed nucleus of the stria terminalis (BNST) contains CRF-producing neurons which seem to be sensitive to stress...
2017: Frontiers in Pharmacology
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